42nd week of 2012 patent applcation highlights part 43 |
Patent application number | Title | Published |
20120264592 | COMPOSITIONS, MATERIALS INCORPORATING THE COMPOSITIONS, AND METHODS OF USING THE COMPOSITIONS AND MATERIALS - The invention relates to composition and methods of using described compositions as oxidative catalysis. In certain embodiments, the invention relates to a composition having a nitrogen oxide species, bromide ion, a metal, and oxygen. In certain embodiments, the composition catalyzes sulfides. | 2012-10-18 |
20120264593 | MANUFACTURING METHOD OF SOLID CATALYST FOR PROPYLENE POLYMERIZATION - Disclosed is a method for preparing a solid catalyst for propylene polymerization, specifically to a method for preparing a solid catalyst for propylene polymerization which can produce a polypropylene having high melt flow rate, a wide molecular distribution and excellent stereoregularity with a high production yield. | 2012-10-18 |
20120264594 | ELECTROCATALYSTS BASED ON MONO/PLURIMETALLIC CARBON NITRIDES FOR FUEL CELLS FUELED WITH HYDROGEN - The invention describes the preparation of electrocatalysts, both anodic (aimed at the oxidation of the fuel) and cathodic (aimed at the reduction of the oxygen), based on mono- and plurimetallic carbon nitrides to be used in PEFC (Polymer electrolyte membrane fuel cells), DMFC (Direct methanol fuel cells) and H | 2012-10-18 |
20120264595 | Transition Metal-Containing Catalysts and Catalyst Combinations Including Transition Metal-Containing Catalysts and Processes for Their Preparation and Use as Oxidation Catalysts - This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of the carbon support. The present invention also relates to catalyst combinations comprising catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of a carbon support and a secondary catalyst or, co-catalyst, including a secondary transition metal. The invention further relates to the field of catalytic oxidation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines. | 2012-10-18 |
20120264596 | HONEYCOMB STRUCTURE AND METHOD OF MANUFACTURING HONEYCOMB STRUCTURE - A honeycomb structure includes a substantially pillar-shaped honeycomb unit having cells defined by cell walls. The cell walls include silicon carbide particles having a nitrogen-containing layer provided on surfaces of the silicon carbide particles. A method of manufacturing a honeycomb structure includes preparing paste containing silicon carbide particles. The paste is molded to form a honeycomb molded body. The honeycomb molded body is fired in an inert atmosphere containing no nitrogen to obtain a substantially pillar-shaped honeycomb unit having cells defined by cell walls. The honeycomb unit is heated in an environment containing nitrogen to provide a nitrogen-containing layer on surfaces of the silicon carbide particles forming the cell walls. | 2012-10-18 |
20120264597 | CEAlO3 PEROVSKITES CONTAINING TRANSITION METAL - Disclosed herein is a perovskite represented by the following Formula (I): A | 2012-10-18 |
20120264598 | SYNTHESIS OF PLATINUM-ALLOY NANOPARTICLES AND SUPPORTED CATALYSTS INCLUDING THE SAME - Methods of synthesizing platinum-alloy nanoparticles, supported catalysts comprising the nanoparticles, and further methods of forming supported catalysts comprising Pt | 2012-10-18 |
20120264599 | METHOD FOR PRODUCING COMPOSITE SILICA PARTICLES - Disclosed is a method for producing composite silica particles and hollow silica particles that can improve the utilization efficiency of a hydrophobic organic substance. It is a method for producing composite silica particles each of which is provided with an outer shell part having a mesoporous structure formed from a silica-containing component and which includes a hydrophobic organic substance in the interior of the aforementioned outer shell part, and involves adding an aqueous solvent to the hydrophobic organic substance and emulsifying, and forming the outer shell part having the mesoporous structure formed from the silica-containing component on the surface of an emulsified oil droplet of the aforementioned hydrophobic organic substance. | 2012-10-18 |
20120264600 | ACTIVATED CARBON/SILICA-GEL/CACL2 COMPOSITE ADSORBENT MATERIAL FOR AIR-CONDITIONING APPLICATIONS AND A METHOD OF PREPARING THE SAME - Provided is a composite adsorbent material and a method for preparing the same. The composite adsorbent material comprises a porous host material of activated carbon impregnated with silica-gel and calcium chloride, and is useful for adsorbing high levels of water vapor. The composite adsorbent material is used in low temperature heat driven adsorption cooling and dehumidification systems. | 2012-10-18 |
20120264601 | SORBENT-COATED ALUMINIUM STRIP - The invention relates to a method for producing an aluminium strip, in which the aluminium strip is coated with a sorption layer which has a binder and a sorbent. The object to propose a method for producing an aluminium strip coated with a sorption layer, by means of which an aluminium strip can be coated cost-effectively having constant performance characteristics with respect to the sorption of, for example, water vapour, is achieved according to the invention by means of a method for producing an aluminium strip coated with a sorption layer by applying a suspension to the aluminium strip in the coil-coating process, which in addition to a liquid comprises at least one binder, formed as a solid, and a sorbent, and by subjecting the aluminium strip, together with the applied suspension, to a drying process, in which the binder is activated. | 2012-10-18 |
20120264602 | COMPOSITION AND METHOD FOR CONTROLLING PESTS - The present invention provides: a composition for controlling pests comprising, as active ingredients, ethaboxam and avermectin; a method for controlling pests which comprises applying effective amounts of ethaboxam and avermectin to a pest, a plant or soil for growing plant; and so on. | 2012-10-18 |
20120264603 | ATTACHMENT AND RETENTION FORMULATIONS FOR BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS - The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof. | 2012-10-18 |
20120264604 | RICE CULTIVAR CL181-AR - A rice cultivar designated CL181-AR is disclosed. The invention relates to the seeds of rice cultivar CL181-AR, to the plants of rice CL181-AR, to methods for producing a rice plant produced by crossing the cultivar CL181-AR with itself or another rice variety, and to methods for controlling weeds in the vicinity of plants of rice cultivar CL181-AR, which comprises increased resistance to acetohydroxyacid synthase-inhibiting herbicides. The invention further relates to hybrid rice seeds and plants produced by crossing the cultivar CL181-AR with another rice cultivar. | 2012-10-18 |
20120264605 | Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients - Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture. | 2012-10-18 |
20120264606 | OIL FORMULATIONS - There is provided a composition comprising an oil medium, wherein particles are suspended in said oil medium, wherein said particles comprise cyclopropene and molecular encapsulating agent, and wherein said particles have median size, as measured by the largest dimension, of 50 micrometer or less. Also provided are a method of making such a composition and a method of treating plants by contact with such a composition. | 2012-10-18 |
20120264607 | USE OF SPECIFIC ALCOHOL ALKOXYLATES AS AN ADJUVANT FOR AGROTECHNICAL APPLICATIONS - The present invention relates to the use of specific amphiphilic alkoxyates as synergistic adjuvant for agrotechnical applications. Suitable agrotechnical compositions are also described. Thus, the addition of such alkoxylates makes possible an accelerated uptake of active ingredients by the plant. | 2012-10-18 |
20120264608 | Method for Improving the Aqueous Solubility of Poorly-Soluble Substances - Provided is a method for increasing the solubility of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, without using large amounts of additives. This is a method for improving aqueous solubility, which comprises coating the surface of the particle of a poorly-soluble substance used in pharmaceutical products, veterinary pharmaceutical products, quasi-drugs, cosmetic products, food products, agricultural chemicals, and the like, with microparticles of a calcium compound such as calcium phosphate or calcium carbonate. | 2012-10-18 |
20120264609 | HYPERBRANCHED POLYESTER HAVING A HYDROPHOBIC CORE FOR SOLUBILIZING ACTIVE INGREDIENTS OF LOW SOLUBILITY - The present invention provides a composition comprising an active ingredient with a maximum solubility in water at 20° C. of 10 g/l, and a hyperbranched polyester which is joined to a polar polymer which comprises a polycondensate or a polymer comprising ethylenically unsaturated monomers. The invention further relates to the hyperbranched polyester mentioned and to a process for preparation thereof. It further relates to the use of the hyperbranched polyester for solubilizing the active ingredient in aqueous compositions. | 2012-10-18 |
20120264610 | Comb Polymer Derivatives of Polyetheramines Useful as Agricultural Dispersants - This invention concerns novel dispersants that are the reaction products of succinic anhydride-containing resins with certain amines. These water soluble dispersants have been found to be unique and highly effective dispersants for water insoluble agricultural suspension concentrate formulations. | 2012-10-18 |
20120264611 | Pesticide Preparations Containing Derivatives Of Pyrrolidone-4-Carboxylic Acid - The invention relates to pesticide preparations that contain one or more pesticides and one or more N-substituted 2-pyrrolidone-4-carboxylic acid derivatives and to the use of said pesticide preparations for controlling and/or combating weeds, fungal diseases, or insect infestation. The N-substituted 2-pyrrolidone-4-carboxylic acid derivatives act as adjuvants, emulsifiers, dispersants, and/or wetting agents in the pesticide preparations. | 2012-10-18 |
20120264612 | BUFFER LAYERS FOR REBCO FILMS FOR USE IN SUPERCONDUCTING DEVICES - A superconducting article includes a substrate having a biaxially textured surface. A biaxially textured buffer layer, which can be a cap layer, is supported by the substrate. The buffer layer includes a double perovskite of the formula A | 2012-10-18 |
20120264613 | Fault Current Limited System with Current Splitting Device - A fault current limiter system including a fault current limiter and a variable shunt current splitting device. The current splitting device includes first and second conductive windings, wherein the first conductive winding is connected in parallel with the fault current limiter and is configured to carry current in a first direction. The second conductive winding is electrically connected in series with the fault current limiter and is configured to carry current in a second direction opposite to the first direction so that the reactance of the first winding is negated by the reactance of the second winding during steady state operation of the fault current limiter system. Thus, a first portion of a steady state current is conveyed through the fault current limiter and a second portion of the current is conveyed through the current splitting device. The steady state current load, on the fault current limiter is thereby reduced. | 2012-10-18 |
20120264614 | LOW TEMPERATURE PRESSURE CHAMBER UNIT, MAGNETIC RESONANCE DEVICE WITH A LOW TEMPERATURE PRESSSURE CHAMBER UNIT, AND AN ATTACHMENT METHOD TO ATTACH AT LEAST ONE ADD-ON UNIT TO AN EXTERNAL HOUSING OF A LOW TEMPERATURE PRESSURE CHAMBER UNIT - In order to attach an add-on unit to a low temperature pressure chamber unit having a low temperature pressure chamber, and an external housing surrounding the low temperature pressure chamber, an attachment device is used to attach at least one add-on unit to the external housing, and the attachment device has an adhesive unit designed for the arrangement and/or attachment of the at least one add-on unit to the external housing. | 2012-10-18 |
20120264615 | CHEMICAL SOLUTION SEED LAYER FOR RABITS TAPES - A method for making a superconducting article includes the steps of providing a biaxially textured substrate. A seed layer is then deposited. The seed layer includes a double perovskite of the formula A | 2012-10-18 |
20120264616 | LENTIVIRAL-BASED VECTOR AND ITS USE IN DIRECTED EVOLUTION OF GENOMIC REGIONS, GENES AND POLYNUCLEOTIDES - The present invention concerns a method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, as well as a method to generate genetic variability by preparing a cell library. This invention also relates to a method to isolate or to screen variants of a polynucleotide or variants of a protein able to impact the phenotype of a cell or to confer a desired phenotype to target cells, and to identify theses polynucleotide variants or protein variants responsible for this phenotype. | 2012-10-18 |
20120264617 | DNA SEQUENCING EMPLOYING NANOMATERIALS - Charge transfer doped nanomaterials such as hydrogen terminated diamond, nanotubes, nanowires or similar nanostructures are used to create a highly sensitive pH sensor, or ion sensitive sensor to directly detect the addition of a newly incorporated nucleotide when performing DNA sequencing by synthesis. A single highly integrated chip can be made to sequence many strands of DNA in a massively parallel fashion in a short amount of time with a direct electronic readout that will bring the cost, size, power consumption of sequencing DNA to very attractive and useful levels. | 2012-10-18 |
20120264618 | QUANTIFICATION OF A MINORITY NUCLEIC ACID SPECIES - The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided. | 2012-10-18 |
20120264619 | MICRORNA AFFINITY ASSAY AND USES THEREOF - The present invention provides methods and kits for determining which microRNAs bind to a target mRNA where the methods comprise the steps of (a) creating a bait sequence from the target mRNA, where the bait sequence comprises a label that binds to a binding agent; (b) adding a mixture of microRNAs to the bait sequence; (c) separating the microRNAs that bind to the bait sequence from those microRNAs that do not bind; and (d) identifying the microRNAs that bind to the bait sequence, wherein the microRNAs identified are those that bind to the target mRNA. | 2012-10-18 |
20120264620 | METHODS FOR DIAGNOSIS AND TREATMENT OF ENDOMETRIAL CANCER - The present invention discloses methods of using endothelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs). | 2012-10-18 |
20120264621 | PHASE-PROTECTING REAGENT FLOW ORDERINGS FOR USE IN SEQUENCING-BY-SYNTHESIS - A method for nucleic acid sequencing includes disposing template polynucleotide strands in defined spaces on a sensor array, at least some of the template polynucleotide strands having a sequencing primer and a polymerase operably bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed according to a predetermined ordering; and determining, for each of the series of flows of nucleotide species, how many nucleotide incorporations occurred for that particular flow to determine a predicted sequence of nucleotides corresponding to the template polynucleotide strands, wherein the predetermined ordering (a) is not a series of consecutive repetitions of a 4-flow permutation of four different nucleotide species, (b) is not specifically tailored to a particular combination of a particular template polynucleotide strand to be sequenced and a particular sequencing primer to be used, and (c) comprises a phase-protecting flow ordering. | 2012-10-18 |
20120264622 | COMBINATORIAL DECODING OF RANDOM NUCLEIC ACID ARRAYS - Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence. | 2012-10-18 |
20120264623 | SYSTEM AND METHOD FOR THE CLONAL CULTURE OF EPITHELIAL CELLS AND APPLICATIONS THEREOF - The invention relates to means and methods for evaluating and using the specific properties of a particular epithelial cell present in a biological sample. Accordingly, the invention relates to a system for the culture of epithelial cells, in which at least one clonal culture is sown with a single epithelial cell directly extracted from a biological sample of epithelial tissue. The invention also relates to a method for the culture of epithelial cells, that particularly comprises the production of clonal cultures, each being sown with a distinct and unique epithelial cell directly extracted from a biological sample of epithelial tissue, the evaluation of the cellular growth in the clonal cultures, and advantageously the analysis of the capacity of the cellular material from the clonal cultures to reconstruct a three-dimensional epithelium representative of native tissue. The invention is adapted for the parallel implementation of a very large number of clonal cultures, in particular for making large-scale tests. | 2012-10-18 |
20120264624 | METHOD AND DEVICE FOR DETECTING ANALYTES IN A SAMPLE LIQUID - A method for detecting analytes in a sample liquid is provided in which the sample liquid is subjected to a mixing treatment on a surface of a support having in particular immobilized reactants, wherein an in particular trough-like vessel with an essentially flat bottom as a support surface for the immobilized reactants is used as the vessel for the sample liquid. The sample liquid is moved relative to the immobilized reactants by an oscillating movement of the vessel during the mixing treatment in one direction, typically along a line or a curve. In addition, a device is provided for carrying out the method according to the present disclosure. | 2012-10-18 |
20120264625 | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF CERVICAL CANCER - The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided. | 2012-10-18 |
20120264626 | MicroRNA Expression Profiling and Targeting in Chronic Obstructive Pulmonary Disease (COPD) Lung Tissue and Methods of Use Thereof - A method for diagnosing and staging of chronic obstructive pulmonary disease (COPD) includes measuring expression of one or more miRNAs levels in a subject suspected of suffering from COPD. | 2012-10-18 |
20120264627 | Oligonucleotide Array For Tissue Typing - Oligonucleotide-based microarrays for tissue typing (e.g., HLA tissue typing) are provided. More particularly, the microarrays are high resolution arrays useful for diagnostic evaluations and determining donor/recipient transplant compatibility. | 2012-10-18 |
20120264628 | Methods for Enriching Microparticles or Nucleic Acids in a Complex Mixture Using Size Exclusion Filtration - Embodiments of the present invention provide methods for the enrichment of rare microparticles, cells, or nucleic acids from a complex mixture using serial size exclusion filtration. Also provided are less invasive methods for detecting chromosomal or genetic abnormalities in a fetus, by enriching fetal microparticles in maternal plasma using serial size exclusion filtration, and isolating and analyzing the fetal nucleic acids from the fetal microparticles. Methods for diagnosis of diseases such as cancer are also provided, including enriching disease specific microparticles in the patient's plasma using serial size exclusion filtration, and isolating and analyzing the nucleic acids from the disease specific microparticles. | 2012-10-18 |
20120264629 | METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE - The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Beta-2-glycoprotein 1 as a diagnostic and prognostic biomarker in renal injuries. | 2012-10-18 |
20120264630 | METHOD FOR DETECTING A CIRCULARIZED DNA, AND USE OF SAID METHOD FOR DETECTING MUTATIONS - The present invention relates to a method for detecting a circularized single-stranded DNA by means of the isothermal hyperbranched rolling circle amplification technique, in which the primers used comprise a detectable barcode sequence and, optionally, a spacer which blocks polymerization by DNA polymerase. The present invention also relates to the use of said method for detecting a genetic polymorphism of one or more base pair(s). | 2012-10-18 |
20120264631 | Targets For Use In Diagnosis, Prognosis And Therapy Of Cancer - Provided herein are targets that can be used for the diagnosis, prognosis and therapy of a variety of cancers. | 2012-10-18 |
20120264632 | Methods for Determining Sequence Variants Using Ultra-Deep Sequencing - The claimed invention provides for new sample preparation methods enabling direct sequencing of PCR products using pyrophosphate sequencing techniques. The PCR products may be specific regions of a genome. The techniques provided in this disclosure allows for SNP (single nucleotide polymorphism) detection, classification, and assessment of individual allelic polymorphisms in one individual or a population of individuals. The results may be used for diagnostic and treatment of patients as well as assessment of viral and bacterial population identification. | 2012-10-18 |
20120264633 | METHODS FOR DETECTING THROMBOCYTOSIS USING BIOMARKERS - The present invention relates to a method to determine the gene expression profile of thrombocytotic sensitive genes. The method comprises the following steps; obtaining hematologic samples from subjects in a training set, analyzing the obtained hematologic samples with a microarray, measuring the expression values of each gene on the microarray, performing analysis to identify differentially expressed genes in the training set among three cohorts of thrombocytosis, obtaining hematologic samples from subjects in an independent testing set, and validating the identity of the differentially expressed genes in the independent testing set among the three cohorts of thrombocytosis. The invention also relates to a method to distinguish thrombocytosis cohorts. The method includes the following steps; obtaining a hematologic sample from a subject, determining gene expression of a biomarker subset, analyzing gene expression of the biomarker subset, and classifying the subject into one of three cohorts. | 2012-10-18 |
20120264634 | Marker Sequences for Pancreatic Cancer Diseases, Pancreatic Carcinoma and Use Thereof - The present invention relates to novel marker sequences for pancreatic cancer diseases, pancreatic carcinoma and the diagnostic use thereof together with a method for screening of potential active substances for pancreatic cancer diseases, pancreatic carcinoma by means of these marker sequences. Furthermore, the invention relates to a diagnostic device containing such marker sequences for pancreatic cancer diseases, pancreatic carcinoma, in particular a protein biochip and the use thereof. | 2012-10-18 |
20120264635 | DETECTION OF CHROMOSOMAL ABNORMALITIES ASSOCIATED WITH PROGNOSIS OF NON SMALL CELL LUNG CANCER - The methods and compositions described herein address the need for a diagnostic method that can be provided to patients with early stage lung cancer, especially non-small cell lung cancer (NSCLC), to determine whether the patient is at increased risk of poor disease outcome. The methods and compositions thus allow for more informed treatment decisions for the early stage lung cancer patient. | 2012-10-18 |
20120264636 | GENETIC VARIANTS INDICATIVE OF VASCULAR CONDITIONS - The invention relates to procedures and methods of determining a susceptibility to certain vascular conditions, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with these conditions. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic methods, uses and procedures for utilizing such markers. | 2012-10-18 |
20120264637 | METHODS AND SYSTEMS FOR PHYLOGENETIC ANALYSIS - Methods and systems for designing and using organism specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting, identifying and quantitating a plurality of biomolecules or microorganisms in a sample based on the hybridization or binding of target molecules in the sample with the probes, including the detection of rare OTU's in a sample. In some cases, methods are provided for selecting an oligonucleotide probe specific for a node on a clustering tree. | 2012-10-18 |
20120264638 | CIRCULATING miRNAs AS NON-INVASIVE MARKERS FOR DIAGNOSIS AND STAGING IN PROSTATE CANCER - The present invention relates to a method for staging prostate cancer in a subject suffering from prostate cancer, said method comprises (a) determining the amount of at least one miRNA selected from the group consisting of miRNA-375, miRNA-141, miRNA-200b, miRNA-516a-3p and miRNA9*, or the amount of a precursor molecule in a sample from said patient and (b) comparing the, thus, determined amount with a reference amount. Moreover, the present invention is concerned with a method for identifying a subject susceptible to prostate cancer therapy and to a method for diagnosing prostate cancer. Further envisaged by the present invention are a kit and a device adapted to carry out the method of the present invention. | 2012-10-18 |
20120264639 | METHODS AND COMPOSITIONS FOR PREDICTING SURVIVAL IN SUBJECTS WITH CANCER - Methods for generating a prognostic signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are disclosed. In some embodiments, the methods include determining expression levels for one or more genes selected from among Fos B, KLF6, NFKBIZ, ATP4A, GSG1, and SIGLEC11 in PDAC cells obtained from the subject, wherein the determining provides a prognostic signature for the subject. Also disclosed are methods for assessing risk of an adverse outcome of a subject with pancreatic ductal adenocarcinoma (PDAC), methods for predicting a clinical outcome of a treatment in a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC), methods for predicting a positive or a negative clinical response of a subject with pancreatic ductal adenocarcinoma (PDAC) to a treatment, and arrays for use in the disclosed methods. | 2012-10-18 |
20120264640 | METHOD FOR DETECTING THE METHYLATION OF COLORECTAL-CANCER-SPECIFIC METHYLATION MARKER GENES FOR COLORECTAL CANCER DIAGNOSIS - The present invention relates to a method for detecting the methylation of colorectal cancer-specific marker genes for colorectal cancer diagnosis, and more particularly to a method of detecting colorectal cancer-specific marker genes, which are methylated specifically in colorectal cancer cells, to provide information for diagnosing colorectal cancer. The use of the inventive method for detecting methylation and the inventive composition, kit and nucleic chip for diagnosing colorectal cancer makes it possible to diagnose colorectal cancer at an early transformation stage, thus enabling the early diagnosis of colorectal cancer. In addition, the inventive method enables colorectal cancer to be effectively diagnosed in an accurate and rapid manner compared to conventional methods. | 2012-10-18 |
20120264641 | METHODS AND KITS FOR IDENTIFYING HUMAN ADENOVIRUS SEROTYPES - Methods, kits, primers and oligonucleotide probes for conveniently and rapidly detecting and identifying four or more human adenovirus (HAdV) serotypes in a sample are provided. Following a nucleic acid amplification reaction with specific primers, serotype specific oligonucleotide probes are used not only to detect HAdV present in a sample but also to discriminate between the HAdV serotypes present in the sample, and in particular to discriminate between the clinically relevant serotypes HAdV-3, HAdV-4, HAdV-7, HAdV-14, and HAdV-21 and/or HAdV-I, HAdV-2, HAdV-5, and HAdV-6. The combination of these primers and oligonucleotide probes permit the rapid and convenient serotyping of HAdV. | 2012-10-18 |
20120264642 | METHODS AND REAGENTS FOR IMPROVED DETECTION OF AMYLOID BETA PEPTIDES - The invention relates to methods for the diagnostic of a neurodegenerative disease, for the detection of a stage prior to a neurodegenerative disease or for distinguishing neurodegenerative disease from a stage prior to a neurodegenerative disease based on the level of certain pools of amyloid beta peptides which are either bound to plasma components or bound to blood cells as well as on certain calculated parameters which are obtained by an arithmetic combination of one or more of the amyloid peptide levels. The invention relates as well to kits for carrying out the above method. | 2012-10-18 |
20120264643 | TSG PRIMER TARGET DETECTION - The present invention relates to the detection of a target nucleic acid sequence in a real-time manner using a target signal generating primer (TSG primer) having dual interactive labels. The present invention allows for both target amplification and signal amplification by introducing dual interactive labels into a primer used in PCR reactions, ensuring real-time target detection by PCR reactions without the use of complicated oligonucleotides. The present invention could be free from the troublesome matters and shortcomings associated with conventional real-time PCR methods. The present invention allows for successful real-time target detection by using only a labeled primer. Also, the present invention can obtain strong signals indicative of the presence of target nucleic acid sequences in both a liquid phase and solid phase. | 2012-10-18 |
20120264644 | Oxide Layers on Silicone Substrates for Effective Confocal Laser Microscopy - Methods of performing confocal laser microscopy on a polymer array disposed on a silicon wafer substrate, the method comprising the steps of providing a silicon wafer substrate having a top side and a bottom side, coating the top side of the silicon wafer with an oxide coating to provide an oxide coated wafer, covalently coupling a plurality of probes to the top side of the coated wafer to provide a fixed polymer array, hybridizing the fixed polymer array with a plurality of labeled ligands, and assaying for one or more hybridized ligands using confocal laser fluorescence microscopy to detect hybridization are provided. | 2012-10-18 |
20120264645 | ANTI-CXCL9, ANTI-CXCL10, ANTI-CXCL11, ANTI-CXCL13, ANTI-CXCR3 AND ANTI-CXCR5 AGENTS FOR INFLAMMATORY DISORDERS - A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a biological sample obtained from the subject; and (b) comparing the level of expression of said one or more inflammatory disease markers in the biological sample to a normal level of expression of the one or more inflammatory disease markers, wherein the one or more inflammatory disease markers comprise one or more markers selected from the group consisting of CXCL9, CXCL10, CXCL11, CXCL13, CXCR3 and CXCR5. Also disclosed are a method for monitoring the course of treatment for an inflammatory disease in a subject and a kit for detecting an inflammatory disease in a subject. | 2012-10-18 |
20120264646 | ENZYME QUANTIFICATION - The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number. | 2012-10-18 |
20120264647 | DONOR SPECIFIC ANTIBODY LIBRARIES - The present invention concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present invention also concerns the method of making and using the donor-specific antibodies. The present invention further concerns the neutralizing antibodies obtained from the donor-specific antibody libraries and the methods of using these antibodies for the prevention/treatment of human disease. | 2012-10-18 |
20120264648 | In Vitro Model Of Spinal Muscular Atrophy - A population of iPS cells derived from somatic cells from a spinal muscular atrophy patient is disclosed. In one embodiment of the invention, the cells have been cultured to produce neural cells. In another embodiment, the invention is a method of testing compounds for their ability to modify cellular SMN levels comprising the steps of obtaining a population of iPS cells derived from a spinal muscular atrophy patient or cells derived from the iPS cells, and examining the effect of a test compound on SMN levels. | 2012-10-18 |
20120264649 | AGENTS FOR ENHANCED CHARGE TRANSPORT ACROSS MICROBIAL MEMBRANES - The invention provides molecules useful for enhancing charge transport across membranes, such as electron transport across membranes, and methods of using such molecules, for example in improving the performance of a microbial fuel cell or in staining microbes for observation. The amphiphilic molecule comprises a conjugated core with hydrophilic groups on either end. The amphiphilic molecule inserts into the membrane of a microbe and facilitates charge transfer across the membrane of the microbe. | 2012-10-18 |
20120264650 | Multiplexed Microarray Assembly and Method for Fabricating a Multiplexed Microarray - Multiplexed microarrays, multiplexed microarray cassettes, and methods for fabricating multiplexed microarrays are disclosed. In some embodiments, the multiplexed microarrays include a substrate, a chamber layer, and at least one channel layer. The topmost channel layer forms a port layer and may be compressible. The multiplexed microarrays may also include a compressible or non-compressible cover or sealing film. The multiplexed microarray cassette includes a base and may also include a cover. The base of the multiplexed microarray cassette includes a plurality of tracks to receive corresponding multiplexed microarrays. | 2012-10-18 |
20120264651 | EVALUATING PROTEINS - The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence and an affinity tag, and (ii) a binding agent that recognizes the affinity tag; contacting the substrate with a translation effector to thereby translate the hybrid amino acid sequence; maintaining the substrate under conditions permissive for the hybrid amino acid sequence to bind the binding agent; and removing the nucleic acid from the substrate. In one embodiment, the substrate includes a plurality of positionally-distinguishable addresses, for example, each includes a different nucleic acid. The addresses can be located a regularly or irregularly spaced locations. | 2012-10-18 |
20120264652 | DIRECTED HETEROBIFUNCTIONAL LINKERS - A heterobifunctional linker that comprises (a) a moiety capable of reversibly coupling the linker to a selected epitope of a target molecule; and (b) a moiety or moieties capable of irreversibly coupling the linker to the target, and optionally a moiety or moieties capable of irreversibly coupling the linker to a solid surface. Also described is a method of orienting molecules, such as proteins, with respect to a surface and to each other, employing such a linker, and an array of such oriented molecules, which may be the same or different. | 2012-10-18 |
20120264653 | Methods for High Fidelity Production of Long Nucleic Acid Molecules - In a method for synthesizing a pool of nucleic acid molecules, a first nucleic acid has a first 5′ region and a first 3′ region and a second nucleic acid has a second 5′ region and a second 3′ region. The second 3′ region and the first 5′ region have identical nucleic acid sequences. The first 3′ region is hybridized with an oligonucleotide, extending the hybridized oligonucleotide and producing a first extension product having a 3′ region complementary to the first 5′ region. The second nucleic acid is hybridized with the first extension product to hybridize the 3′ region of the first extension product to the second 3′ region, extending the 3′ region of the first extension product and producing a second extension product having a 3′ region complementary to the second 5′ region. Error-containing molecules are separated from error-free molecules by a component that selects for a sequence error. | 2012-10-18 |
20120264654 | DIAGNOSTIC ELEMENT, AND A DIAGNOSTIC DEVICE COMPRISING A DIAGNOSTIC ELEMENT - The invention relates to a diagnostic element. The diagnostic element comprises an inlet passage, a holding port and an outlet passage. The holding port is capable of encapsulating a diagnostic gel. The invention also relates to a diagnostic device that comprises at least one inlet port, a preparation port, a diagnostic element that comprises an inlet passage, a holding port, an outlet passage and an outlet port. | 2012-10-18 |
20120264655 | THERMO-RESPONSIVE HYDROGELS AND THERMO-RESPONSIVE POLYMER SOLUTIONS - Polymers and hydrogels that are provided that are thermo-responsive, such as thermo-thickening polymers and hydrogels, as well as aqueous solutions whose rheological properties may be modified by including the polymers, hydrogels, or combinations thereof. Such thermo-responsive polymers or hydrogels, or aqueous solutions including the polymers or hydrogels, may be used as additives to reservoir drilling fluids (RDF's), fluid loss control (FLC) pills, hydraulic fracturing fluids (frac fluids), and lost circulation (LC) pills. The polymers or hydrogels may impart a rheological profile that is generally flat with respect to variations in the shear-rate and temperature environment in which drilling fluids, RDF's, FLC pills, frac fluids, and LC pills are deployed. Embodiments include the process of producing a high performance filtercake through the application of thermo-responsive hydrogels and/or thermo-responsive polymer solutions. | 2012-10-18 |
20120264656 | COMPOSITION OF SPECIAL FLUID AND USE - Composition of special fluid comprising at least one hydrogenated mono- and/or at least one polyterpene, in a mixture with at least one special fluid for industrial applications such as the petroleum industry, in construction as sealants and paints, adhesives, the inks industry, metal working, the treatment and protection of metals, but also for domestic uses and in the agric-food and plumbing industries. | 2012-10-18 |
20120264657 | Emulsion Stabilizing Agents for Drilling and Completion Fluids - Stabilized emulsion compositions comprising an oleaginous fluid, a fluid that is at least partially immiscible with the oleaginous fluid, and, an emulsion stabilizing agent. The emulsion stabilizing agent comprises a first ionic compound soluble in the oleaginous fluid or the fluid that is at least partially immiscible with the oleaginous fluid and a second ionic compound with a charge of opposite sign of the first ionic compound and that is at least partially soluble in the opposite fluid as the first ionic compound. The first ionic compound and the second ionic compound are selected from the group consisting of: a cationic ionic surfactant, an anionic surfactant, a cationic polyelectrolyte, an anionic polyelectrolyte, and a combination thereof. | 2012-10-18 |
20120264658 | Methods to Characterize Fracture Plugging Efficiency for Drilling Fluids - Of the many compositions and methods provided herein, one method includes providing a drilling fluid comprising a base drilling fluid and a plurality of particulates, wherein the base drilling fluid without the particulates is characterized by N | 2012-10-18 |
20120264659 | Methods to Modify Drilling Fluids to Improve Lost Circulation Control - Of the many compositions and methods provided here, one method includes providing a drilling fluid comprising a lost circulation material and a base drilling fluid, wherein the base drilling fluid comprises an oleaginous continuous phase and a polar organic molecule, wherein the base drilling fluid has a first normal stress difference magnitude (|N | 2012-10-18 |
20120264660 | Method of Tracking Fluids Produced from Various Zones in Subterranean Well - A traceable treatment composition for treating a subterranean formation having multiple zones penetrated by a well bore comprising a homogenous blend of a tracking composition and a resin composition. The tracking composition comprises a substantially non-radioactive tracking material selected from the group consisting of a metal salt. The metal portion of the metal salt may be selected from the group consisting of gold, silver, lithium, molybdenum, and vanadium. The metal salt may also be selected from the group consisting of: barium bromide, barium iodide, beryllium fluoride, beryllium bromide, beryllium chloride, cadmium bromide, cadmium iodide, chromium bromide, chromium chloride, chromium iodide, cesium bromide, cesium chloride, sodium bromide, sodium iodide, sodium nitrate, sodium nitrite, potassium iodide, potassium nitrate, manganese bromide, zinc bromide, zinc iodide, sodium monofluoroacetate, sodium trifluoroacetate, sodium 3-fluoropropionate, potassium monofluoroacetate, potassium trifluoroacetate, and potassium 3-fluoropropionate. | 2012-10-18 |
20120264661 | BASE OIL FOR COOLING DEVICE, DEVICE-COOLING OIL CONTAINING THE BASE OIL, DEVICE TO BE COOLED BY THE COOLING OIL, AND DEVICE COOLING METHOD USING THE COOLING OIL - A base oil for cooling a device contains a hydrocarbon compound at 30 mass % or more and exhibits a kinematic viscosity of 4 mm | 2012-10-18 |
20120264662 | FUNCTIONALIZED MONOMERS - This invention relates to functionalized monomers. The functionalized monomer may be reacted with an enophilic reagent (e.g., maleic anhydride) to form an enophilic reagent modified functionalized monomer. The invention relates to lubricants, functional fluids, fuels, dispersants, detergents, functional compositions (e.g., food products, cleaners, etc.), and the like. | 2012-10-18 |
20120264663 | Lubricant Composition - A lubricant composition which is suitable as a fluorine oil, fluorine grease, and which is excellent in stabilizability, as well as a lubricant composition which is suitable as a fluorine oil, fluorine grease, and which has excellent rust prevention properties while keeping a heat resistance. | 2012-10-18 |
20120264664 | MALIENATED DERIVATIVES - This invention relates to malienated derivatives made from maleic anhydride, functionalized monomers, and one or more additional reagents, e.g., an oxygen-containing reagent (e.g., alcohol, polyol), a nitrogen-containing reagent (e.g., amine, polyamine, aminoalcohol), a metal and/or a metal compound. The invention relates to lubricants, functional fluids, fuels, dispersants, detergents and functional compositions (e.g., cleaning solutions, food compositions, etc.) | 2012-10-18 |
20120264665 | LUBRICANT BLENDS WITH PAO-BASED DISPERSANTS - Provided is a lubricant blend including one or more lubricant base stocks and one or more dispersants. The dispersant is chosen from a polyalphaolefin succinimide, a polyalphaolefin succinamide, a polyalphaolefin acid ester, a polyalphaolefin oxazoline, a polyalphaolefin imidazoline, a polyalphaolefin succinamide imidazoline, and combinations thereof. The one or more dispersants are present at 2 to 20 wt % based on the total weight of the blend. The one or more dispersants and the one or more lubricant base stocks are together present at 8 wt % or more of the total weight of the blend. Provided is also a process for making the lubricant blend and a method for the service life of a lubricant. | 2012-10-18 |
20120264666 | MOLYBDENUM DIALKYLDITHIOCARBAMATE COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME - A novel molybdenum dithiocarbamate composition is produced by preparing a di-tridecylamine (DTDA) intermediate from a butylene feedstock comprising greater than 50% 2-butylene, and preparing a molybdenum dithiocarbamate composition from the DTDA intermediate. The resulting molybdenum dithiocarbamate composition are according to formula (1), wherein R | 2012-10-18 |
20120264667 | AZEOTROPIC COMPOSITIONS COMPRISING FLUORINATED COMPOUNDS FOR CLEANING APPLICATIONS - The present invention relates to compositions comprising fluorinated olefins or fluorinated ketones, and at least one alcohol, halocarbon, hydrofluorocarbon, or fluoroether and combinations thereof. In one embodiment, these compositions are azeotropic or azeotrope-like. In another embodiment, these compositions are useful in cleaning applications as a degreasing agent or defluxing agent for removing oils and/or other residues from a surface. | 2012-10-18 |
20120264668 | DETERGENTS OR CLEANING AGENTS CONTAINING A BLEACH-ENHANCING TRANSITION METAL COMPLEX WHICH IS OPTIONALLY PRODUCED IN SITU - A bleach catalyst includes a complex of Fe—, Mo—, Mn— and/or W with a ligand having a skeleton of formula (I). | 2012-10-18 |
20120264669 | COMBINATION OF POLYMER AND SURFACTANT FOR IMPROVED LAUNDRY - A polyester soil-release polymer (a) and a cosurfactant (b) are used in a laundry composition to improve primary detergency, secondary detergency, and/or soil anti-redeposition and/or to allow a reduction of the amount of surfactant(s) and/or builder(s). Also disclosed is a performance additive comprising at least 20% by weight as actives, of a mixture of (a), (b) and optionally water or other products, in an amount by weight if present of lower than 80%, and the performance additive is mixed with other ingredients to make a laundry composition. | 2012-10-18 |
20120264670 | DETERGENTS OR CLEANING AGENTS CONTAINING A BLEACH-ENHANCING TRANSITION METAL COMPLEX WHICH IS OPTIONALLY PRODUCED IN SITU - The aim of the invention is to improve the cleaning power of detergents and cleaning agents, especially with regard to bleachable stains, while avoiding any damage to the textile treated with said detergents and cleaning agents. For this purpose, a bleach catalyst in the form of a complex of Fe—, Mo—, Mn— and/or W with a ligand having a skeleton of formula (I) is used. | 2012-10-18 |
20120264671 | METHODS AND COMPOSITIONS FOR REMOVING RESIDUES AND SUBSTANCES FROM SUBSTRATES USING ENVIRONMENTALLY FRIENDLY SOLVENTS - Environmentally friendly solvents used to dissolve or remove residues and/or substances from substrates wherein the residue and/or substance is contacted with a Generally Recognized As Safe solvent to dissolve the residue and/or substance in the solvent followed by the extraction of the residue and/or substance from the solvent such as by contact with carbon dioxide. | 2012-10-18 |
20120264672 | MACHINE CLEANING METHOD - An automatic dishwashing method using a bleaching-agent-free cleaning-agent presentation form comprising a plurality liquid cleaning agent preparations being dispensed into the interior of an automatic dishwasher, in the course of the cleaning method, from a cartridge located preferably in the interior of the cleaning machine, wherein a sub-quantity of each of the cleaning-agent preparation located in the cartridge is dispensed into the interior of the cleaning machine, a residual quantity of each of the cleaning-agent preparations located in the cartridge remaining in the cartridge until the end of the cleaning method, and said residual quantity corresponding to at least twice the quantity of the sub-quantity dispensed. | 2012-10-18 |
20120264673 | Environmentally friendly, multi-purpose refluxing cleaner - A solvent blend cleaner useful for reflux cleaning of chemical manufacturing equipment, including that used in manufacturing pharmaceuticals, comprises a blend of environmentally friendly and safe solvents selected on the basis of specific criteria, such as vapor pressure, vapor density, boiling point, specific heat, and heat of vaporization, among other things; achieves excellent cleaning even upon further dilution with water; and avoids the disadvantages associated with the use of conventional commodity solvents in reflux cleaning methods. Desired solvency, cleaning and wetting properties of the inventive formulations in use can be achieved through blending of solvents having the selected criteria. Additives, such as surfactants, can be added to enhance cleaning and lower solvent requirements. | 2012-10-18 |
20120264674 | METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS - The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications. | 2012-10-18 |
20120264675 | CMV GENE PRODUCTS PROMOTE CANCER STEM CELL GROWTH - The disclosure relates generally to compositions and methods useful for inhibiting the infection and propagation of viral particles, particularly members of the Herpesviridae family, and more particularly to cytomegalovirus (CMV) and methods of treating diseases and disorders, including cell proliferative disorders, associated with CMV infection. | 2012-10-18 |
20120264676 | MULTI-COMPONENT ANTIOXIDANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR REDUCING OR PREVENTING OXIDATIVE STRESS - An antioxidant compound is disclosed, along with pharmaceutical compositions and methods of treatment which utilize said compound. The compound is characterized by a peptide including at least three amino acid residues of which at least two are cysteine residues, and a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, as described herein. Cleavage of the peptide by an intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation. | 2012-10-18 |
20120264677 | OXIDANT RESISTANT APOLIPOPROTEIN A-1 AND MIMETIC PEPTIDES - A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation. | 2012-10-18 |
20120264678 | METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF FOR TREATING INFECTIOUS DISEASES - Disclosed are methods of treating infectious diseases comprising administering to an animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent. | 2012-10-18 |
20120264679 | 3-ETHER AND 3-THIOETHER SUBSTITUTED CYCLOSPORIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF HEPATITIS C INFECTION - This invention relates to cyclosporin derivatives of general formula (I): | 2012-10-18 |
20120264680 | REGULATION OF ENERGY METABOLISM AND OBESITY BY MODULATING B CELL ACTIVATING FACTOR (BAFF, BLYS) OR BAFF SIGNALING - Provided herein are methods and compositions for modulating energy metabolism and weight in mammals, in particular by modulating thermogenesis associated with brown fat, including thermogenesis by brown fat or brown fat cells, adaptive thermogenesis by brown fat or brown fat cells, thermogenic capacity of brown fat or brown fat cells, or a combination thereof. More specifically, methods and compositions provided herein for treating or preventing obesity, or methods and compositions for identifying compounds effective for treating or preventing obesity are taught in connection with ligands such as B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL), their receptors, and molecules that modulate the interactions between the ligands and receptors. | 2012-10-18 |
20120264681 | BUFFERED OPHTHALMIC COMPOSITIONS AND METHODS OF USE THEREOF - The present disclosure provides a buffered ophthalmic composition for formulation of topically administrable suspensions useful for treating eye disorders by promoting wound healing, delivery of pharmaceutically active agents, and lubricating the eye. In particular the ophthalmic composition includes a buffer solution compatible with application to a mammalian eye, wherein the buffer provides increased mechanism of action of pharmaceutically active agents as well as therapeutic qualities. The ophthalmic composition exhibits dual therapeutic action to alleviate various eye disorders as it concomitantly treats corneal ulcerations and excessive inflammation which results from various eye injuries. | 2012-10-18 |
20120264682 | TISSUE PROTECTIVE PEPTIDES AND USES THEREOF - Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides. | 2012-10-18 |
20120264683 | USE OF AN FGF-21 COMPOUND AND A GLP-1 COMPOUND FOR THE TREATMENT OF OBESITY - The present invention provides methods of lowering body weight by administering an FGF-21 compound in combination with a GLP-1 compound. In addition, the present invention also provides methods to treat obesity by administering an FGF-21 compound in combination with a GLP-1 compound. The present invention also discloses combinations useful in the methods of the present invention. | 2012-10-18 |
20120264684 | Glycosylated Form of Antigenic GLP-1 Analogue - Disclosed is a glucagon-like peptide-1 (GLP-1) analogue which is obtained by ameliorating a highly antigenic GLP-1 analogue so that the GLP-1 analogue has reduced antigenicity without being lowered in the blood glucose suppressing activity. Specifically disclosed is a glycosylated form of an antigenic GLP-1 analogue, which has GLP-1 activity and is obtained by substituting at least one amino acid of an antigenic GLP-1 analogue with a glycosylated amino acid. | 2012-10-18 |
20120264685 | SHORT CHAIN PEPTIDOMIMETICS BASED ORALLY ACTIVE GLP 1 AGONIST AND GLUCAGON RECEPTOR ANTAGONIST - The present invention provides novel short chain peptidomimetics, which act as GLP-1 receptors agonist and glucagon receptor antagonist. These dual acting peptidomimetics exhibit increased stability to proteolytic cleavage, especially against DPP-IV (Dipeptidyl peptidase-IV) enzyme, GIT enzymes such as pepsin and acidic stomach pH and also against liver microsomes (in vitro). Due to increased metabolic stability, other than parenteral route of administration, these short chain peptidomimetics can be delivered by oral routes of administration, for the treatment or prevention of diabetes and related metabolic disorders, such as obesity, hyperlipidemia and eating disorders. | 2012-10-18 |
20120264686 | MODIFIED ERYTHROPOIETIN (EPO) POLYPEPTIDES THAT EXHIBIT INCREASED PROTEASE RESISTANCE AND PHARMACEUTICAL COMPOSITIONS THEREOF - Modified erythropoietin (EPO) polypeptides and other modified therapeutic polypeptides are provided. The EPO polypeptides and other therapeutic polypeptides are modified to exhibit physical properties and activities that differ from the unmodified EPO polypeptides and other unmodified therapeutic polypeptides, respectively. Nucleic acid molecules encoding these polypeptides also are provided. Also provided are methods of treatment and diagnosis using the polypeptides. | 2012-10-18 |
20120264687 | MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED - An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain. | 2012-10-18 |
20120264688 | PROCESS FOR THE PURIFICATION OF RECOMBINANT HUMAN ERYTHROPOIETIN (EPO), EPO THUS PURIFIED AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME - A procedure for the production of erythropoietin (EPO), in particular recombinant human EPO (rhEPO) with a defined composition of glycoforms in a highly pure form, i.e., with a high amount of O-glycosylated EPO isoforms is provided. | 2012-10-18 |
20120264689 | METHODS AND COMPOSITIONS FOR SKIN REGENERATION - Compositions and methods for inducing tissue differentiation and growth within a localized area of application in humans or other animals are provided. Compositions comprising a biological or pharmacologically active agent such as Insulin-like Growth Factor-1 (IGF-1) and sustained-release nanoparticle formulations comprising IGF-1 and a matrix forming component such as hyaluronan for use in skin repair and regeneration are provided. Nanoparticles of the invention activate endogenous stem cells in the local area of administration to produce new dermal cells and tissues. | 2012-10-18 |
20120264690 | METHODS OF USING BASIC FIBROBLAST GROWTH FACTOR TO PREVENT ACUTE WOUND FAILURE - Methods for preventing incisional hernia formation and acute wound failure are described. More particularly, methods are described for preventing incisional hernia formation and acute wound failure by administering a composition comprising basic fibroblast growth factor. In addition, a drug delivery device to administer basic fibroblast growth factor is described. | 2012-10-18 |
20120264691 | MEDICAL COMPOSITIONS CONTAINING GHRELIN - It is provided a pharmaceutical composition stably containing ghrelin or its derivative, which is an endogenous growth hormone secretagogue (GHS) to a growth hormone secretagogue-receptor (GHS-R), comprising a aqueous solution containing the ghrelins having pH range of 2 to 7, wherein the aqueous solution having pH range of 2 to 7 is a buffer solution, especially, glycine hydrochloride buffer, acetate buffer, citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphate buffer, phosphate-acetate-borate buffer or phthalate buffer, and the concentration of the ghrelins in the solution is from 0.03 nmol/mL to 6 μmol/mL. | 2012-10-18 |