42nd week of 2017 patent applcation highlights part 27 |
Patent application number | Title | Published |
20170298326 | VARIANT FORMS OF URATE OXIDASE AND USE THEREOF - Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidase are described. | 2017-10-19 |
20170298327 | MODIFIED POLYMERASES FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES - Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same. | 2017-10-19 |
20170298328 | POLYNUCLEOTIDES ENCODING MHC CLASS I-RESTRICTED HTERT EPITOPES, ANALOGUES THEREOF OR POLYEPITOPES - This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogues thereof and polyepitopes containing such epitopes and/or analogues. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer. | 2017-10-19 |
20170298329 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES - Provided are compositions and methods for the treatment of hemoglobinopathies such as thalassemias and sickle cell disease. Compositions and methods include one or more endonuclease(s) or endonuclease fusion protein(s), including one or more homing endonuclease(s) and/or homing endonuclease fusion protein(s) and/or CRISPR endonuclease(s) and/or CRISPR endonuclease fusion protein(s): (a) to disrupt a Bcl11a coding region; (b) to disrupt a Bcl11a gene regulatory region; (c) to modify an adult human β-globin locus; (d) to disrupt a HbF silencing DNA regulatory element or pathway, such as a Bcl11a-regulated HbF silencing region; (e) to mutate one or more γ-globin gene promoter(s) to achieve increased expression of a γ-globin gene; (f) to mutate one or more δ-globin gene promoter(s) to achieve increased expression of a δ-globin gene; and/or (g) to correct one or more β-globin gene mutation(s). | 2017-10-19 |
20170298330 | Set of Polypeptides Exhibiting Nuclease Activity or Nickase Activity with Dependence on Light or in Presence of Drug or Suppressing or Activating Expression of Target Gene - The present invention provides, for example, a set of two polypeptides exhibiting the nuclease activity with dependence on light or in the presence of a drug, in which an N-terminal side fragment and a C-terminal side fragment of a Cas9 protein are bound to each of two polypeptides which form a dimer with dependence on light or in the presence of a drug. | 2017-10-19 |
20170298331 | GENETIC CORRECTION OF MUTATED GENES - Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes. | 2017-10-19 |
20170298332 | A MODIFIED BETA-FRUCTOFURANOSIDASE FOR FRUCTOOLIGOSACCHARIDE PRODUCTION - The invention provides variants of the | 2017-10-19 |
20170298333 | Variants of Glycoside Hydrolases - The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 2017-10-19 |
20170298334 | STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA - The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including | 2017-10-19 |
20170298335 | Highly Potent Acid Alpha-Glucosidase With Enhanced Carbohydrates - Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described. | 2017-10-19 |
20170298336 | Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2017-10-19 |
20170298337 | METHODS FOR EXTRACTING AND PURIFYING NON-DENATURED PROTEINS - Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and purifying proteins that denature at low temperature. | 2017-10-19 |
20170298338 | THERMOSTABLE BLUNT-END LIGASE AND METHODS OF USE - Fusion proteins having thermostable blunt-end ligase activity are provided. Blunt-end ligases are useful for DNA amplification, sequencing, production of recombinant DNA and recombinant fusion proteins, and other purposes. These thermostable blunt-end DNA ligases are useful in ligation schemes which include, e.g., an incubation at about 60-65° C. or higher, or as high as about 94° C., or at other temperatures. The ligases disclosed herein may enable high temperature blunt-end ligation without need for molecular crowding agents, and so may be useful for many nucleic acid ligation-amplification schemes, e.g., ones which operate at a uniform temperature (e.g., at about 60° C. or higher), including ones which require temperature cycling, e.g., from about 94° C. to about 60° C. (or higher) for one, two, three, or more cycles. The thermostable blunt-end DNA ligases disclosed herein enable higher specificity target amplification, for example, by permitting temperature denaturation of double-stranded DNA templates as well as specific primer binding. | 2017-10-19 |
20170298339 | Engineered Stable Microorganism/Cell Communities - Engineered stable multi-organism (or multi-cell type) communities encapsulated in a media that slows or prohibits certain metabolic functions such as cell division, but maintains other metabolic functions. | 2017-10-19 |
20170298340 | Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus - Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber. | 2017-10-19 |
20170298341 | Methods for Culturing Cells in an Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus - Provided herein are models comprising a tissue-like assembly of cells tissues or organoid bodies cultured in the presence of a pulsating alternating ionic magnetic resonance field. The cells, tissues or organoid bodies are introduced into a culture unit comprising growth and nutrient modules in which the gravity vector of the growth unit is continually randomized and cultured in the presence of the alternating ionic magnetic resonance field. | 2017-10-19 |
20170298343 | METHOD OF IDENTIFYING OR PRODUCING AN APTAMER - The invention relates to a method of identifying or producing an aptamer, and a reagent comprising a nucleic acid ligand capable of binding a target sample, wherein the nucleic acid ligand comprises at least one nucleobase modified to contain an azide-alkyne chemical group. | 2017-10-19 |
20170298344 | De Novo Design of Allosteric Proteins - Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided. | 2017-10-19 |
20170298345 | COMPOSITIONS AND METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT AND HIGH EFFICIENCY LIBRARY GENERATION - The present invention provides methods, compositions and kits for targeted nucleic acid sequence enrichment in a nucleic acid sample and for high efficiency nucleic acid library generation for next generation sequencing (NGS). Specifically, the methods, compositions and kits provided herein are useful for the production and capture of amplification-ready, target-specific and strand-specific regions of interest from nucleic acid samples containing complex DNA. | 2017-10-19 |
20170298346 | Dnazyme-nanoparticle conjugates and methods of use thereof - The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as genomic material or transcripts of infectious agents, such as viruses, exemplified by applications demonstrating visual detection of Flavivirus RNA molecules, such as dengue virus, or Alphavirus RNA molecules, such as chikungunya virus, in short time periods, using compositions comprising stable components. | 2017-10-19 |
20170298347 | NOVEL FUSION-CIRCULAR RNAs AND USES THEREOF - Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided. Non-human animals expressing exogenous f-circRNA and complements thereof are also provided. | 2017-10-19 |
20170298348 | GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES - The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological injury in a human subject using genetically modified human neural stem cells. | 2017-10-19 |
20170298349 | INTERGENIC RNAS AND METHODS FOR MODULATING GENE EXPRESSION AND PATHOGENESIS IN CANDIDA - Intergenic non-coding RNA molecules that regulate the expression of HWP1 and ALS3 of | 2017-10-19 |
20170298350 | METHODS AND COMPOSITIONS FOR USE OF NON-CODING RNA IN CELL CULTURING AND SELECTION - Described herein are methods and compositions for producing a gene of interest (GOD, which, in certain embodiments, can reduce the metabolic burden on cells and reduce decoupling of GOI production from marker production, as compared to prior art methods. The methods relate to positive selection and negative selection approaches to establishing high GOI-producing cell lines, e.g., CHO lines. In certain embodiments, the methods comprise transfecting a cell with (a) an oligonucleotide comprising a GOI and a non-coding RNA, and (b) an oligonucleotide encoding a selection protein; wherein the non-coding RNA promotes or inhibits production of the selection protein. The cell producing the can be identified and/or selected as a result of or by detecting the absence or the presence of the selection protein. | 2017-10-19 |
20170298351 | Method For Screening Interfering Molecules - A method for screening interfering nucleic acids enhancing the expression or the activity of expressed gene sequences is described. The method includes a step of introducing, into a cell, a hybrid nucleic acid molecule having: a first non-coding sequence intended to initiate translation; a second sequence complementary to the interfering nucleic acids to be screened; and, optionally, a third nucleotide sequence encoding at least one pre-determined peptide, the first sequence being modified such that the translation level of the at least one peptide is reduced by at least 10%. | 2017-10-19 |
20170298352 | COMPOSITIONS AND METHODS FOR TREATING HEPATIC FIBROSIS - This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an unmet medical need. The exosome compositions contain an effective amount of exosomes isolated from a body fluid of a non-diseased subject. The compositions are useful in the treatment of a variety of fibrotic diseases. | 2017-10-19 |
20170298353 | ENHANCING DERMAL WOUND HEALING BY DOWNREGULATING MICRORNA-26A - Methods for enhancing wound healing, e.g., in diabetic subjects, by administering an antagonist of miR-26a, e.g., an inhibitory nucleic acid that targets miR-26a. | 2017-10-19 |
20170298354 | ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES - The present disclosure relates to methods of treating heat stock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF. | 2017-10-19 |
20170298355 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) - The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. | 2017-10-19 |
20170298356 | Binding and Catalytic Molecules Built from L-DNA with Added Nucleotides - This invention provides for processes for binding to and/or chemically transforming a preselected target, where the process involves contacting said target to an oligonucleotide molecule that contains one or more “non-standard” nucleotides, which are nucleotide analogs that, when incorporated into oligonucleotides (DNA or RNA, collectively xNA), present to a pattern of hydrogen bonds that is different from the pattern presented by adenine, guanine, cytosine, and uracil. This disclosure provides an example where such an oligonucleotide molecule is built from both D- and L-mirror image carbohydrates in the backbone. It also provides a process for obtaining these binders and/or transformers by a laboratory in vitro selection process that exploits rolling circle amplification rather than the polymerase chain reaction. | 2017-10-19 |
20170298357 | Treatment of HIV - Described herein are silencing nucleic acids, compositions comprising silencing nucleic acids, and methods of utilizing the silencing nucleic acids to to inhibit HIV replication in a cell infected with HIV. In some embodiments, the disclosed methods comprise contacting a cell or population of cells infected with HIV with at least one silencing nucleic acid that targets a specific sequence of the 5′ LTR of HIV. | 2017-10-19 |
20170298358 | TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS USING RNA COMPLEXES THAT TARGET CONNECTIVE TISSUE GROWTH FACTOR - In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit CTGF expression and are therefore useful for treating idiopathic pulmonary fibrosis. | 2017-10-19 |
20170298359 | OLIGONUCLEOTIDE TARGETED TO THE A20-THREE PRIME UNTRANSLATED REGION - An antisense oligonucleotide comprising a sequence targeted to the 3′ untranslated region (3′ UTR) of the TNFAIP3 (A20) transcript and its use as a medicament, for example in the treatment of cancer or an autoimmune disease. | 2017-10-19 |
20170298360 | LATS AND BREAST CANCER - The present invention relates to a method for treating breast cancer in a subject having a breast cancer of the estrogen receptor (ERα) negative type, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the Large Tumor Suppressor Kinase (LATS). Also provided are a siRNA decreasing or silencing the expression of the Large Tumor Suppressor Kinase (LATS), and an antibody specifically binding to the Large Tumor Suppressor Kinase (LATS), for use to treat breast cancer of the estrogen receptor (ERα) negative type. | 2017-10-19 |
20170298361 | USE OF AGENTS FOR TREATING FAT-RELATED DISORDERS - Use of agents that down-regulates an amount and/or activity of Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or checkpoint kinase 1 (Chk1) in the production of a medicament for treating obesity are disclosed. | 2017-10-19 |
20170298362 | ANTI-TUMOR THERAPY - Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive. | 2017-10-19 |
20170298363 | NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY - The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA, or oxaloacetate and acetyl-CoA. Embodiments of the invention include microbial organisms having a pathway to acetyl-CoA and oxaloacetate that includes phosphoketolase (a PK pathway). The organisms also have either (i) a genetic modification that enhances the activity of the non-phosphotransferase system (non-PTS) for sugar uptake, and/or (ii) a genetic modification(s) to the organism's electron transport chain (ETC) that enhances efficiency of ATP production, that enhances availability of reducing equivalents or both. The microbial organisms can optionally include (iii) a genetic modification that maintains, attenuates, or eliminates the activity of a phosphotransferase system (PTS) for sugar uptake. The enhanced carbon flux through acetyl-CoA and oxaloacetate can be used for production of a bioderived compound, and the microbial organisms can further include a pathway capable of producing the bioderived compound. | 2017-10-19 |
20170298364 | FUSION PROTEIN, NANOPARTICLE COMPOSED OF A PLURALITY OF MONOMERS OF SAID FUSION PROTEIN, AND USES THEREOF - A fusion protein based on the heavy chain of human ferritin is described, which includes at the N terminus of the protein at least one metalloproteinase cleavage sequence and a PAS polypeptide that acts as a masking polymer that increases the protein-drug stability, as well as a nanoparticle composed of multiple monomers of said fusion protein, a nucleic acid encoding for said fusion protein, and diagnostic and therapeutic applications thereof. | 2017-10-19 |
20170298365 | PROTEIN MUNS THAT CAN FORM INCLUSIONS IN THE ENDOPLASMIC RETICULUM, METHODS FOR THE USE THEREOF AND USES OF SAME - The invention relates to a polynucleotide encoding a polypeptide based on the minimum region of the Orthoreovirus muNS protein that can form inclusions in the endoplasmic reticulum, and to said polypeptide. The invention also relates to a purification method and a method for detecting interaction between two polypeptides based on the capacity of some regions of the Orthoreovirus muNS protein to incorporate themselves into the inclusions, together with a peptide of interest. | 2017-10-19 |
20170298366 | EXPRESSION CASSETTE INCLUDING AN rrnA PROMOTER DERIVED FROM VIBRIO NATRIEGENS FOR ENHANCING THE GROWTH RATE OF ESCHERICHIA COLI AND RECOMBINANT ESCHERICHIA COLI HAVING THE SAME INTRODUCED THEREINTO - The present disclosure relates to an expression cassette including an rrnA promoter derived from | 2017-10-19 |
20170298367 | AUTO-INDUCIBLE EXPRESSION SYSTEM - A method for the expression of a protein of interest by a bacterium, notable in that it comprises the culturing of a bacterium temporarily or continuously expressing an Hsp protein, in that said bacterium also comprises a nucleic acid sequence, encoding a protein of interest, under the control of a lac promoter and in that said bacterium is cultured in a medium which does not contain IPTG or a metabolized molecule in such a way as to automatically induce the induction of transcription from the lac promoter. | 2017-10-19 |
20170298368 | UREOHYDROLASES AS DOMINANT SELECTABLE MARKERS IN YEAST - The invention relates to a nucleic acid molecule encoding a novel selection marker. Said marker is a guanidinobutyrase from | 2017-10-19 |
20170298369 | FUSION PROTEINS COMPRISING IMMUNOGLOBULIN CONSTANT DOMAIN-DERIVED SCAFFOLDS - This disclosure features fusion proteins comprising a base protein linked to or incorporated in a CH2 scaffold of IgG. The CH2 scaffold can derive from the macaque CH2 domain of IgG. The fusion proteins can effectively bind a single or multiple targets, and can be engineered to regulate effector functions as desired. The fusion proteins can have an increased serum half-life, solubility, stability, protease resistance, and/or expression as compared to the scaffolds alone and/or as compared to the base protein alone. This disclosure also features fusion proteins comprising a base protein, a CH2 scaffold and a discrete polyethylene glycol (dPEG) linked to the scaffold via a serine, tyrosine, cysteine, lysine, or a glycosylation site of the scaffold. This disclosure additionally features scaffolds linked to a discrete polyethylene glycol (dPEG) via a serine, tyrosine, cysteine, or lysine of the scaffolds or a glycosylation site of the scaffold. | 2017-10-19 |
20170298370 | Viral Based Transient-Expression Vector System That Allows Multiple Applications - Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease. Specifically exemplified herein are methods of transfecting woody trees that allow multiple applications of vectors while avoiding superinfection exclusion. | 2017-10-19 |
20170298371 | Method for Transforming a Plant Cell or Plant Tissue Using Agrobacterium, Transgenic Plant, Transgenic Cell or Transgenic Tissue, Culture Medium and Use of a Method for Transforming a Plant Cell or Tissue - There are provided compositions and methods for transforming plants, preferably monocot, and even more preferably, sugarcane. The transformation methods involve infection of plant tissue with | 2017-10-19 |
20170298372 | SOYBEAN IF5A PROMOTER AND ITS USE IN CONSTITUTIVE EXPRESSION OF TRANSGENIC GENES IN PLANTS - The disclosure relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean eukaryotic translation initiation factor 5A-2-likegene and fragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The disclosure further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same. | 2017-10-19 |
20170298373 | PLANT PROMOTER AND 3'UTR FOR TRANSGENE EXPRESSION - This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a | 2017-10-19 |
20170298374 | COMPOSITIONS AND METHODS OF DELIVERING MOLECULES TO PLANTS - Compositions and method of delivering a molecule to a plant are provided. In an embodiment, an avenic acid transporter is introduced into a plant. The plant may be a non-graminacious or dicotyledonous plant which does not comprise the transporter in the wild type form. The transporter may be modified to increase uptake of avenic acid along with iron chelated by the avenic acid and/or a molecule conjugated with the avenic acid. Further embodiments provide for conjugating the avenic acid with a molecule for uptake and delivery to the plant. In this manner plant health may be improved by uptake of iron where it would otherwise not occur and/or uptake of the conjugated molecule. The molecule may be a molecule that improves health of the plant. Still further embodiments provide for analogs of avenic acid. Embodiments provide for interplanting | 2017-10-19 |
20170298375 | CONTROL OF CELLULOSE BIOSYNTHESIS BY OVEREXPRESSION OF A TRANSCRIPTION FACTOR - The invention relates to nucleic acids, proteins and methods for modulating the cellulose content of plants. | 2017-10-19 |
20170298376 | TOBACCO PLANTS EXHIBITING ALTERED PHOTOSYNTHESIS AND METHODS OF MAKING AND USING - This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants. | 2017-10-19 |
20170298377 | METHODS OF CONTROLLING SEED SIZE IN PLANTS - This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in | 2017-10-19 |
20170298378 | GENES TO PROVIDE ENVIRONMENTAL STRESS TOLERANCE AND THE USE THEREOF - It is intended to provide a gene capable of conferring more practical environmental stress tolerances to a plant and the use thereof. The present invention provides a plant having enhancement in one or two or more genes selected from the group consisting of a second gene selected from a gene group consisting of a first gene subgroup consisting of Os12g0150200 gene, Os01g0858350 gene, Os05g0445100 gene, Os11g0151400 gene, AT3G48520 gene, and AT2G27690 gene, and a gene functionally equivalent to any of these genes and a second gene subgroup consisting of Os04g0584800 gene and a gene functionally equivalent to this gene. | 2017-10-19 |
20170298379 | FUNCTIONAL MUTANT ALLELES OF EIN5 FOR YIELD INCREASE - This disclosure relates to novel mutant alleles for increasing biomass in plants and provides mutant plants comprising alleles and chimeric genes encoding the novel alleles. | 2017-10-19 |
20170298380 | IMIDAZOLINONE HERBICIDE RESISTANT BORAGE - The present disclosure provides borage plants having increased resistance to imidazolinone herbicides. More particularly, provided herein are methods for generating herbicide resistant borage and testing of selected progeny for homozygosity. Nucleic acids encoding AHAS 1 and 2 genes that encode herbicide resistance in borage are provided. | 2017-10-19 |
20170298381 | COMBINATION OF FOUR VIP AND CRY PROTEIN TOXINS FOR MANAGEMENT OF INSECT PESTS IN PLANTS - The subject invention includes methods and plants for controlling lepidopteran pests, especially soybean looper ( | 2017-10-19 |
20170298382 | GENETIC REDUCTION OF MALE FERTILITY IN PLANTS - Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate and maintain such plants and methods of use of said plants, are provided, including use of parental plants to produce sterile plants for hybrid seed production. | 2017-10-19 |
20170298383 | WHEAT MS1 POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USE - Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and variants thereof, which modulate male fertility. Expression cassettes comprise a male-fertility polynucleotide, or fragment or variant thereof, operably linked to a promoter, wherein expression of the polynucleotide modulates the male fertility of a plant. The level and/or activity of a polynucleotide that influences male fertility is modulated in a plant or plant part. Regulatory sequences drive expression in a male-tissue-preferred manner and may be targets to downregulate an operably linked gene. Methods to track mutations that induce nuclear recessive male sterility in subsequent selfing and crossing of wheat lines containing the mutations are also provided. Male-sterile plants may be maintained by pollinating with a maintainer plant. | 2017-10-19 |
20170298384 | STEM CELL GENE TARGETING - The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus. | 2017-10-19 |
20170298385 | TARGETED DELETION OF CELLULAR DNA SEQUENCES - Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites. | 2017-10-19 |
20170298386 | TURKEY HERPESVIRUS VECTORED RECOMBINANT CONTAINING AVIAN INFLUENZA GENES - The present invention provides a recombinant turkey herpesvirus modified by the presence of the cDNA encoding the hemagglutinin protein of avian influenza virus under a promoter. A poultry vaccine comprising the recombinant turkey herpesvirus described in the present invention can induce serological responses that may be easily detected by the hemagglutination inhibition assay but not by commercially available diagnostic ELISA kits; thus enabling easy differentiation between vaccination and field infection. | 2017-10-19 |
20170298387 | VIRUS-BASED EXPRESSION VECTORS AND USES THEREOF - Expression vectors ideal for use in vaccinating individuals against disease based on vaccinia virus and other chordopoxviruses having high expression of recombinant genes and low expression of vector genes in target animals, and low expression of recombinant genes and high expression of vector genes in cells used for propagation. | 2017-10-19 |
20170298388 | METHOD OF DETECTING AND/OR IDENTIFYING ADENO-ASSOCIATED VIRUS (AAV) SEQUENCES AND ISOLATING NOVEL SEQUENCES IDENTIFIED THEREBY - Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided. | 2017-10-19 |
20170298389 | HSV VACCINES - Provided herein are improved vaccines for HSV-2. | 2017-10-19 |
20170298390 | HIGH EFFICIENCY, HIGH THROUGHPUT GENERATION OF GENETICALLY MODIFIED MAMMALS BY ELECTROPORATION - The invention described herein provides high throughput methods and reagents for generating transgenic animals (e.g., mammals) through introducing materials into gametes or preimplantation stage (e.g., one-cell embryo or zygotes) via electroporation, leading to genetically inheritable modification to the genome of the animal. | 2017-10-19 |
20170298391 | CONDITIONAL RESCUE SYSTEM, CELLS, AND METHODS - A conditional rescue system generally includes a gene transfer system, a polynucleotide including a nuclease-resistant target coding region, and a coding region encoding a conditionally-lethal polypeptide. The gene transfer system is effective to integrate into host cell DNA. The polynucleotide including the nuclease-resistant target coding region is under transcriptional control of an inducible promoter. The coding region encoding a conditionally-lethal polypeptide is transcriptionally linked to the target coding region. | 2017-10-19 |
20170298392 | Lignin Compositions and Methods for Use in Fermentation and Animal Feed - This disclosure includes methods utilizing lignin or modified lignin compositions to reduce undesirable effects of unwanted microbial growth in fermentation media or animal feed, including lignin or modified lignin compositions that may be used in or for such methods. | 2017-10-19 |
20170298393 | Processes and Systems for Alcohol Production and Recovery - The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present invention also relates to processes for recovering butanol produced in a fermentative process in a butanol production plant that may be converted to ethanol production plant. | 2017-10-19 |
20170298394 | Process For Producing Ethanol And Fermenting Organisms - Processes for producing ethanol comprise saccharifying cellulosic material with a cellulolytic enzyme composition and fermenting the saccharified cellulosic material with a fermenting microorganism to produce ethanol. The fermenting organism is | 2017-10-19 |
20170298395 | AUTOTROPHIC HYDROGEN BACTERIA AND USES THEREOF - In an aspect, the invention relates to compositions and methods production of n-butanol by aerobic hydrogen bacteria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2017-10-19 |
20170298396 | BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS - Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters. | 2017-10-19 |
20170298397 | Method for Producing Dicarboxylic Acid - A method for producing a dicarboxylic acid is provided. A dicarboxylic acid is produced by culturing a bacterium having a dicarboxylic acid-producing ability, which has been modified so that the expression of one or more of the yeeA gene, ynfM gene, yjjP gene, and yjjB gene is increased, in a medium, and collecting the dicarboxylic acid from the medium. | 2017-10-19 |
20170298398 | GENETIC MODIFICATION OF (S)-LACTIC ACID PRODUCING THERMOPHILIC BACTERIA - A genetically engineered thermophilic bacterial cell that is facultative anaerobic and (S)-lactic producing including inactivation or deletion of the endogenous methylglyoxal synthase gene mgsA. | 2017-10-19 |
20170298399 | BIOSYNTHESIS OF CANNABINOID PRODRUGS AND THEIR USE AS THERAPEUTIC AGENTS - The present invention provides methods for producing cannabinoid prodrugs. Also described are pharmaceuticals acceptable compositions of the prodrugs and a system for the large-scale production of the prodrugs. | 2017-10-19 |
20170298400 | METHOD FOR PRODUCING PSICOSE - A method of preparing D-psicose includes a step of reacting D-fructose as a substrate and an epimerase thereof in microorganisms at a temperature of 40° C. or higher. The method may further includes inducing the microorganisms to have resting cells by culturing the microorganisms in a medium not containing the D-fructose before the reaction. The method of preparing D-psicose may significantly improve the production amount of D-psicose and production rate of D-psicose. | 2017-10-19 |
20170298401 | ISOTHERMAL NUCLEIC ACID AMPLIFICATION - An isothermal process for amplifying a nucleic acid target molecule that relies on an upstream primer, a downstream primer, a strand invasion system and an oligonucleotide, wherein the upstream and downstream primers are not substrates for the strand invasion system during the amplification process and do not amplify the target molecule independently of the strand invasion system, wherein the oligonucleotide is a substrate for the strand invasion system. | 2017-10-19 |
20170298402 | SELF-LABELING NUCLEIC ACIDS AND METHODS OF USE - Some aspects of this disclosure relate to the identification of reactive nucleic acids, such as, for example, reactive cellular RNAs. Minimal reactive motif consensus sequences and isolated reactive nucleic acids conforming to such consensus sequences are provided herein. Reactive probes that selectively form covalent bonds with reactive nucleic acids are also provided herein, as are methods of using such probes, for example, for labeling, identification, characterization, and/or quantification of reactive nucleic acids. This disclosure further provides fusion molecules comprising a reactive nucleic acid conjugated to a heterologous molecule of interest, such as a heterologous nucleic acid or protein. Methods and kits for generating and using such fusion proteins to track, detect, and/or quantify molecules of interest in a biological sample are also provided as are expression constructs encoding fusion molecules of reactive nucleic acids and heterologous nucleic acids of interest. | 2017-10-19 |
20170298403 | PRODUCTION OF NUCLEIC ACID - A method for the production of nucleic acid encoding a target protein. The method comprises (a) providing an array of RNA or DNA molecules including one or more encoding the target protein; (b) generating a target protein from the array to form RNA-protein or DNA-protein complexes in which the RNA or DNA molecule is non-covalently or covalently bound to the complex; (c) separating the complexes into compartments wherein most or all of the compartments contain n o more than one complex; (d) subjecting the complexes to reaction conditions which allow target protein activity; and (e) selecting nucleic acid encoding the target protein on the basis of the activity associated therewith, wherein when the complex is a DNA-protein complex in which the DNA is non-covalently bound, step b) is performed in the absence of separate compartments for each complex. | 2017-10-19 |
20170298404 | RECOMBINANT PRODUCTION OF STEVIOL GLYCOSIDES - Recombinant polypeptides having UDP-glycosyltransferase activities, including a 1,2-19-O-glucos glycosylation activity and a 1,2-13-O-glucos glycosylation activity for synthesizing of steviol glucosides, are provided. A method of producing a steviol glycoside composition using such recombinant polypeptide is also provided. Also disclosed are steviol glycosides referred to as rebaudioside Z1 and rebaudioside Z2. | 2017-10-19 |
20170298405 | CMP-DEPENDENT SIALIDASE ACTIVITY - The present disclosure is directed to the properties of certain glycosyltransferase variants having N-terminal truncation deletions or internal deletions. Any of the mutants disclosed in here exhibit α-2,6-sialyltransferase enzymatic activity in the presence of CMP-activated sialic acid as co-substrate, and in the presence of a suitable acceptor site. A fundamental finding documented in the present disclosure is that suchs enzyme are not only capable of catalyzing transfer of a sialidyl moiety but they are also capable of catalyzing hydrolytic cleavage of terminally bound sialic acid from a glycan. | 2017-10-19 |
20170298406 | SALT OF PHENYLGLYCINE METHYL ESTER - The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methyl ester free base. | 2017-10-19 |
20170298407 | ENGINEERED WATER NANOSTRUCTURES (EWNS) AND USES THEREOF - Various embodiments of the present invention relate to, among other things, systems for generating engineered water nanostructures (EWNS) comprising reactive oxygen species (ROS) and methods for inactivating at least one of viruses, bacteria, bacterial spores, and fungi in or on a wound of a subject in need thereof or on produce by applying EWNS to the wound or to the produce. | 2017-10-19 |
20170298408 | AUTOMATED METHOD FOR ANALYZING AND INTERPRETING AN ANTIMICROBIAL SUSCEPTIBILITY - The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype. | 2017-10-19 |
20170298409 | SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS - The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration agents in a sampling device can provide for rapid, low cost, simple (involving no complex equipment or procedures), and/or effective processes under a variety of conditions. | 2017-10-19 |
20170298410 | BREAST MILK ETHANOL SCREENING SYSTEM AND METHOD - A test kit detects the presence of a target analyte in a fluid sample. In particular, the test kit includes reagents capable of detecting the target analyte of interest in breast milk. More particularly, the test kit is capable of detecting the presence of alcohol, caffeine, nicotine, drugs of abuse, therapeutic drugs, triglycerides, lactose, capsaicin, and gluten, for example, in breast milk. | 2017-10-19 |
20170298411 | SYSTEM AND METHOD FOR DETECTING OF ALPHA-METHYLACYL-COA RACEMASE (AMACR) AND PROSTATE CANCER - A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H | 2017-10-19 |
20170298412 | METHOD AND KIT FOR MEASURING TARGET NUCLEIC ACID CONTAINING MODIFIED NUCLEOBASE - The present invention provides a method and means that can specifically detect a target nucleic acid containing a modified nucleobase. | 2017-10-19 |
20170298413 | METHODS FOR THE ISOLATION OF BIOMOLECULES AND USES THEREOF - This disclosure is directed, in part, toward preparing and utilizing tunable electrostatic capture (“TEC”) ligands that have an ionizable function. The electrostatic nature of the ionizable functionality of the TEC ligands can be “tuned” or adjusted to either reversibly bind or release a desired target anion, such as a biomolecule, by varying the pH and/or the ionic strength of the binding conditions and release conditions. The TEC ligands can be bound to a solid support to form TEC binding surfaces. TEC surfaces, ligands, solid supports and the accompanying methods and buffer systems can be used to isolate polyanions, such as nucleic acids, from materials, for example in a size-selective manner. | 2017-10-19 |
20170298414 | MOLECULAR DIAGNOSIS AND TYPING OF LUNG CANCER VARIANTS - Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes that are monitored for gene expression. The gene expression is capable of distinguishing between normal lung parenchyma and the major morphological types of lung cancer. The gene expression and somatic mutation data are useful in developing a complete classification of lung cancer that is prognostic and predictive for therapeutic response. The methods are suited for analysis of paraffin-embedded tissues. Methods of the invention include means for monitoring gene or biomarker expression including PCR and antibody-based detection. The biomarkers of the invention are genes and/or proteins that are selectively expressed at a high or low level in certain tumor subtypes. Biomarker expression can be assessed at the protein or nucleic acid level. | 2017-10-19 |
20170298415 | METHOD FOR NUCLEIC ACID ANALYSIS DIRECTLY FROM AN UNPURIFIED BIOLOGICAL SAMPLE - A method is provided for generating single-stranded DNA circles from a biological sample. The method comprises the steps of: treating the biological sample with an extractant to release nucleic acids, thereby forming a sample mixture; neutralizing the extractant; denaturing the released nucleic acids to generate single-stranded nucleic acids; and contacting the single-stranded nucleic acids with a ligase that is capable of template-independent, intramolecular ligation of single-stranded DNA to generate the single-stranded DNA circles. All the steps of the method are performed without any intermediate nucleic acid isolation or nucleic acid purification. The single-stranded DNA circles may be amplified and further analyzed. Also provided is a kit which comprises compositions for carrying out the novel methods. | 2017-10-19 |
20170298416 | INTERFACIAL EFFECTS ENABLE DROPLET ACTUATION, INHIBITION RELIEF, AND EARLY SENSING OF POLYMERASE CHAIN REACTION - Disclosed are devices, systems and methods of use utilizing interfacial effects enabling droplet actuation, inhibition and early sensing of molecular reactions, such as of polymerase chain reaction. | 2017-10-19 |
20170298417 | System and Method for Nucleic Acids Containing Fluid Processing - A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device magnetically separates the particles. The heating and separating devices move into at least one operative position for processing the fluids and at least one inoperative position with respect to the containers, in which the containers are kept stationary at least during and in-between incubating the fluids and manipulating the magnetically responsive particles. | 2017-10-19 |
20170298418 | METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR CONDITIONS ASSOCIATED WITH MICROBIOME FUNCTIONAL FEATURES - A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model. | 2017-10-19 |
20170298419 | RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF - Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-CreI-derived meganuclease are provided. Also provided are recombinant nucleic acids, cells, and organisms containing such recombinant nucleic acids, as well as cells and organisms produced using such meganucleases. Also provided are methods of conducting a custom-designed, I-CreI-derived meganuclease business. | 2017-10-19 |
20170298420 | RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF - Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-CreI-derived meganuclease are provided. Also provided are recombinant nucleic acids, cells, and organisms containing such recombinant nucleic acids, as well as cells and organisms produced using such meganucleases. Also provided are methods of conducting a custom-designed, I-CreI-derived meganuclease business. | 2017-10-19 |
20170298421 | Method for Identification of Sensitivity of a Patient to Telomerase Inhibition Therapy - The invention provides methods for determining the susceptibility of cancer patients to developing adverse reactions if treated with a telomerase inhibitor drug by measurement of telomere length in appropriate cells of the patient prior to initiation of the telomerase inhibitor treatment. | 2017-10-19 |
20170298422 | SIMULTANEOUS SINGLE-MOLECULE EPIGENETIC IMAGING OF DNA METHYLATION AND HYDROXYMETHYLATION - Provided herein is a method for analyzing genomic DNA. In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the DNA molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled DNA molecules on a support, and imaging individual molecules of hydroxymethylated genomic DNA on the support. | 2017-10-19 |
20170298423 | PROBES FOR IMPROVED MELT DISCRIMINATION AND MULTIPLEXING IN NUCLEIC ACID ASSAYS - Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of primers or probes that comprise a non-natural nucleotide linked to a reporter. Target nucleic acids are detected by the polymerization of a complementary probe or primer that incorporated a cognate non-natural nucleotide linked to a quencher. | 2017-10-19 |
20170298424 | NUCLEIC ACID ANALYSIS - A method of analysing for a single stranded nucleic acid present, or potentially present, in a sample comprises a step in which the target nucleic acid (if present in the sample) displaces—and hybridises to—a reporter strand originally present in an interrogating duplex structure comprised of the reporter strand and a displaceable shorter strand. The reporter strand is tagged at or adjacent one end thereof with a reporter moiety capable of providing a detectable signal. The reporter/target duplex structure is such that the reporter strand may be selectively enzymatically digested (e.g. by means of λ-exonuclease) from its end opposite the reporter moiety to release that moiety for direct or indirect detection and regenerate single stranded target, which may then cycle through a plurality of the displacement and digestion steps to result in amplification of signal. | 2017-10-19 |
20170298425 | THERMAL BIOSWITCHES AND RELATED GENETIC CIRCUITS, VECTORS, CELLS, COMPOSITIONS, METHODS AND SYSTEMS - Temperature sensitive transcriptional bioswitches and related genetic circuits and in particular bandpass and/or multiplex genetic circuits, vectors, cells, compositions methods and systems are described. | 2017-10-19 |
20170298426 | SYSTEMS AND METHODS FOR LOCALIZED SURFACE PLASMON RESONANCE BIOSENSING - Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface plasmon resonance (LSPR) antennae are affixed. The LSPR antennae can be affixed via an affixation surface of the LSPR antenna. The LSPR antennae can have a functional surface opposite the affixation surface. Each functional surface can be functionalized by a plurality of single-stranded DNA. | 2017-10-19 |