43rd week of 2015 patent applcation highlights part 31 |
Patent application number | Title | Published |
20150299706 | THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER - The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation. | 2015-10-22 |
20150299707 | CONSTRUCTION OF POOL OF INTERFERING NUCLEIC ACIDS COVERING ENTIRE RNA TARGET SEQUENCE AND RELATED COMPOSITIONS - The present invention provides a PCR based high-throughput method for preparing full-sites siRNA polynucleotide pool, comprising: DNase I random digestion; Loop-1 phosphate linker ligation; single PCR amplification; a type III restriction/modification enzyme digestion; blunt ending; Loop-2 phosphate linker ligation; double primer PCR; FokI digestion and cloning into an siRNA expression vector. The present invention enables the use of a type III restriction/modification enzyme linkers mediated PCR method for high-throughput preparing an siRINA polynucleotide pool, in which the functional length of siRNAs can be controllably distributed from 19-23 bp, thus completely mimic the natural siRNA length diversity, specially suitable for RNAi therapeutic targets screening. The present invention overcomes the bottlenecks and drawbacks of conventional siRNA polynucleotide pool construction technologies. | 2015-10-22 |
20150299708 | CD133 APTAMERS FOR DETECTION OF CANCER STEM CELLS - The present disclosure relates to RNA aptamers and uses thereof, in particular, aptamers which specifically bind to CD 133 and which demonstrate superior tumour penetration. | 2015-10-22 |
20150299709 | NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO SALMONELLA AND USE THEREOF - A nucleic acid molecule utilizable for | 2015-10-22 |
20150299710 | Inhibitory Oligonucleotide and Use Thereof - The inhibitory oligonucleotides (ODNs) which strongly block NF-κB activation induced by TLR9 agonists and TLR7 agonists are provided. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor alpha, is inhibited by the inhibitory-ODNs. Interferon production from human PBMC induced by TLR9 agonist is prevented by the inhibitory-ODNs. These ODNs can be used as a remedy for the treatment of immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes. | 2015-10-22 |
20150299711 | COMPOSITION FOR TREATING CANCER ASSOCIATED WITH HPV INFECTION - The present invention relates to a composition for preventing or treating diseases associated with human papillomavirus (HPV), and more specifically, cancer associated with HPV, and even more specifically, cervical cancer. The nucleotide sequence of the present invention, the sequence in which the base thereof is modified, and a specific combination thereof can be useful in a composition for effectively treating diseases associated with HPV infection by greatly inhibiting the expression of the E6/E7 gene of HPV type 16 or 18. | 2015-10-22 |
20150299712 | Modulation of Hematopoietic Stem Cell Differentiation - The invention provides means of manipulating hematopoietic stem cell differentiation by modulation of levels of NR2F6 (EAR2). Provided are compositions of matter, protocols and methods of use by which inhibiting expression of NR2F6 or activity thereof promotes differentiation of selective hematopoietic lineages, or conversely overexpression of NR2F6 or activity thereof inhibits differentiation. In one embodiment inhibition of differentiation is performed in other cell lineages besides hematopoietic. | 2015-10-22 |
20150299713 | METHODS FOR STABILIZING PRODUCTION OF ACETYL-COENZYME A DERIVED COMPOUNDS - The present disclosure relates to the use of a switch for the production of heterologous non-catabolic compounds in microbial host cells. In one aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured under aerobic conditions followed by microaerobic conditions, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. In another aspect, provided herein are genetically modified microorganisms that produce non-catabolic compounds more stably when serially cultured in the presence of maltose followed by the reduction or absence of maltose, and methods of producing non-catabolic compounds by culturing the genetically modified microbes under such culture conditions. | 2015-10-22 |
20150299714 | COMPOSITIONS AND METHODS FOR GENETIC CONSTRUCTS - In an aspect, the invention relates to compositions and methods for genetic constructs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2015-10-22 |
20150299715 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES - The present invention relates to an NADP(H) nanosensor comprising
| 2015-10-22 |
20150299716 | METHOD OF ELIMINATING DEPENDENCE OF METHANOL INDUCED PROMOTER ON SINGLE METHANOL CARBON SOURCE - Provided is a method of eliminating the dependence of methanol induced promoter on a single methanol carbon source for expressing foreign polypeptide. The method comprises activating the expression of the promoter requiring methanol induction by increasing the expression quantity of Mit1 polypeptide in cells of methylotrophic yeast, so that the promoter originally depending on methanol induction no longer depends on single methanol and can also express foreign polypeptide. | 2015-10-22 |
20150299717 | Transgenic Plants with Modified Sugar Content and Methods of Generating Same - This application provides and discloses small RNAs and their target genes that are involved in controlling the levels of sucrose, glucose, and fructose and methods of modulating expression or activity of these mi RNAs and target genes. This application further provides transgenic plants, plant parts, e.g., seeds, that have altered expression of these mi RNAs and target genes and have increased levels of sucrose, increased sucrose to glucose ratios, increased sucrose to hexose ratios, altered carbohydrate levels, or increased Brix in fruit from transgenic plants. This application also provides methods of producing and growing transgenic plants or seeds that have increased levels of sucrose, increased sucrose to glucose ratios, increased sucrose to hexose ratios, altered carbohydrate levels, or increased Brix in fruit from transgenic plants. | 2015-10-22 |
20150299718 | Engineering Plants for Efficient Uptake and Utilization of Urea to Improve - The present disclosure provides polynucleotides and related polypeptides related to urea uptake. The disclosure provides genomic sequences for urea transporter, urease and glutamine synthetase genes. Urea transporters, urease and glutamine synthetase are responsible for controlling nitrogen utilization efficiency in plants. Urea transporter, urease or glutamine synthetase sequences are provided for improving grain yield and plant growth. The disclosure further provides recombinant expression cassettes, host cells and transgenic plants. | 2015-10-22 |
20150299719 | TRANSGENIC TREE INDUCED BY RABG3BCA AND USE THEREOF - Provided to a transgenic tree induced by RabG3bCA and a use thereof. The transgenic tree serves to control xylem growth through RabG3b of | 2015-10-22 |
20150299720 | EXPRESSION OF MICROBIAL PROTEINS IN PLANTS FOR PRODUCTION OF PLANTS WITH IMPROVED PROPERTIES - Recombinant constructs and methods useful for improvement of plants are provided. In particular, recombinant constructs comprising promoters functional in plant cells positioned for expression of polynucleotides encoding polypeptides from microbial sources are provided. The disclosed constructs and methods find use in production of transgenic plants to provide plants, particularly crop plants, having improved properties. | 2015-10-22 |
20150299721 | BIOMASS PRODUCTION INCREASING GENE AND TRANSGENIC PLANT USING SAME - The present invention relates to, inter alia, a gene which increases biomass production isolated from | 2015-10-22 |
20150299722 | NOVEL IRON-ZINC BINDING CONTROL FACTOR, AND TECHNIQUE FOR IMPROVING IRON DEFICIENCY TOLERANCE OF PLANT AND ENHANCING IRON AND ZINC ACCUMULATION IN EDIBLE PART THEREOF BY CONTROLLING EXPRESSION OF NOVEL IRON-ZINC BINDING CONTROL FACTOR - According to the present invention, a transformant and a gene-disrupted strain are provided which exhibit growth superior to that of ordinary plants in calcareous soil, and which can accumulate iron and zinc in large quantities in both calcareous soil and good soil; also provided are a gene, vector, protein, and antibody used for constructing these, and a method of construction, a composition for construction, a kit for construction, and a breeding method for a plant with improved iron deficiency tolerance, and enhanced iron and zinc accumulation in an edible part. The protein of the present invention is an iron- and zinc-binding regulatory factor, and includes any one of the following amino acid sequences of (a) to (c): (a) an amino acid sequence represented by SEQ ID NO:1 or 2; (b) an amino acid sequence obtained by deletion, substitution, or addition of one to several amino acids in the amino acid sequence represented by SEQ ID NO:1 or 2; or (c) an amino acid sequence which has 80% or more identity with the amino acid sequence represented by SEQ ID NO:1 or 2. | 2015-10-22 |
20150299723 | PLANTS WITH ALTERED ROOT ARCHITECTURE, RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING LEUCINE RICH REPEAT KINASE (LLRK) POLYPEPTIDES AND HOMOLOGS THEREOF - Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering root structure of plants, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant, wherein said polynucleotide encodes a polypeptide useful for altering plant root architecture. | 2015-10-22 |
20150299724 | Transgenic Plants Exhibiting Improved Resistance to Abiotic Stress - This application provides and discloses small RNAs and their target genes that are involved in response and resistance to abiotic stresses, and methods of modulating expression or activity of these small RNAs and target genes. This application further provides transgenic plants, plant parts, e.g., seeds, that have altered expression or activity of these small RNAs and target genes and have improved abiotic stress tolerance. This application also provides methods of producing and growing transgenic plants or seeds that have improved abiotic stress tolerance. In specific embodiments, this application discloses small RNAs, small RNA target genes, and uses thereof to improve plant abiotic stress tolerance. In specific embodiments, this application also discloses mi RNA, mi RNA target genes, and uses thereof to improve plant drought tolerance. | 2015-10-22 |
20150299725 | Plants Having Increased Tolerance to Herbicides - The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type or a mutated protoporphyrinogen oxidase (PPO) which is resistant or tolerant to a PPO-inhibiting herbicide by applying to said site an effective amount of said herbicide. The invention further refers to plants comprising wild-type or mutated PPO enzymes, and methods of obtaining such plants. | 2015-10-22 |
20150299726 | AHAS MUTANTS - The invention provides nucleic acids encoding mutants of the acetohydroxyacid synthase (AHAS) large subunit comprising at least two mutations, for example double and triple mutants, which are useful for producing transgenic or non-transgenic plants with improved levels of tolerance to AHAS-inhibiting herbicides. The invention also provides expression vectors, cells, plants comprising the polynucleotides encoding the AHAS large subunit double and triple mutants, plants comprising two or more AHAS large subunit single mutant polypeptides, and methods for making and using the same. | 2015-10-22 |
20150299727 | Improved Methods for Inducing Apomixis in Plants - The present invention relates to methods for inducing apomixis in a plant, methods for the production of apomictic plants and the plants and plant seeds obtained thereby. | 2015-10-22 |
20150299728 | TC-83-DERIVED ALPHAVIRUS VECTORS, PARTICLES AND METHODS - The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs. | 2015-10-22 |
20150299729 | ULTRAHIGH THROUGHPUT MICROINJECTION DEVICE - Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This can be implemented satisfactorily by microinjection. However, disadvantages of traditional manual microinjection include high degree of operator skill, low throughput and labor-intensiveness. Many studies have focused on developing automated and high-throughput systems for microinjection to address these limitations. However, none have provided sufficient throughput for applications such as ex vivo cell therapy, where manipulation of many cells is helpful. | 2015-10-22 |
20150299730 | INKJET GENE PRINTING - Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest. | 2015-10-22 |
20150299731 | Grain Processing - The present invention provides a process for producing biogas and/or methane from solid spent cereal products derived from, for example, the mashing process of malt whisk(e)y and/or beer production. There is also provided a system for producing biogas and/or methane from solid spent cereal products derived from, for example, the mashing process of malt whisk(e)y and/or beer production. | 2015-10-22 |
20150299732 | PRODUCTION OF ISOPRENOIDS - A recombinant yeast that makes an isoprenoid compound is provided. The yeast comprises an endogenous mevalonate pathway comprising (i) an enzyme that converts acetyl-CoA to acetoacetyl-CoA, (ii) an enzyme that converts acetoacetyl-CoA to hydroxymethylglutaryl-CoA, (iii) an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, (iv) an enzyme that converts mevalonic acid to phosphomevalonic acid, (v) an enzyme that converts phosphomevalonic acid to phosphomevalonate, and (vi) an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. The yeast further comprises heterologous nucleic acid sequences encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid, an enzyme that converts mevalonic acid to phosphomevalonic acid, an enzyme that converts phosphomevalonic acid to phosphomevalonate, and an enzyme that converts phosphomevalonate to isopentenyl pyrophosphate. Carbon flow through the mevalonate pathway is increased in the recombinant yeast compared to a yeast that does not comprise the heterologous nucleic acid molecule encoding an enzyme that converts hydroxymethylglutaryl-CoA to mevalonic acid. | 2015-10-22 |
20150299733 | Mutant Beta-Glucosidases Having Enhanced Activity and a Method for Producing Bioethanol Using the Same - The present invention relates to beta-glucosidase that is mutated to have enhanced activity, and a method for producing bioethanol using the same. More particularly, the present invention relates to a polynucleotide encoding beta-glucosidase that is mutated to have enhanced activity, beta-glucosidase expressed from the polynucleotide, an expression vector including the polynucleotide, a transformant that is transformed with the expression vector, a method for producing the mutated beta-glucosidase using the transformant, and a method for producing bioethanol using the transformant. The mutant beta-glucosidase of the present invention increases production of glucose much more than the conventional beta-glucosidase, and thus it can be widely used for economic production of bioethanol. | 2015-10-22 |
20150299734 | Non-Sterile Fermentation of Bioethanol - A range of concentrations exists in which fermentation inhibitors derived from pretreatment of lignocellulosic feed stocks inhibit growth of lactic acid bacteria without affecting fermentive yeast. By optimizing levels of fermentation inhibitors to fall within this range, yeast fermentations of lignocellulosic biomass can be conducted under non-sterile conditions with ethanol yields comparable to those achieved under sterile conditions. Optimised inhibitor levels can be achieved by controlling the water/biomass ratio of a lignocellulosic biomass during and after pretreatment, for example by washing the fiber fraction of a previously pretreated lignocellulosic biomass with a pre-defined amount of fresh water or recycled process solutions. Crude extracts of liquid fraction or process solutions from pretreatment of lignocellulosic biomass can also provide an effective anti-baterial treatment for first generation starch fermentations. | 2015-10-22 |
20150299735 | PROCESSES AND SYSTEMS FOR DRY-MILLED CORN ETHANOL AND CORN OIL PRODUCTION WITH IMPROVED CARBON FOOTPRINT - The present invention improves corn dry milling in several ways. Integrated corn biorefinery processes are disclosed which can produce ethanol, edible corn oil, DDG or DDGS, solvent-extracted meal, power, and optionally crude corn oil, starting from corn. Some variations employ corn fractionation and edible corn oil recovery using liquid carbon dioxide, avoiding hazardous hydrocarbon-based solvents to produce edible corn oil. Some variations employ integration of gas-fired co-generation into the dry-milled corn ethanol plant to significantly reduce energy usage and carbon footprint associated with the overall process. Counter-current drying is preferably employed to produce a high-quality DDG or DDGS product with high protein content, low mycotoxin content, and low residual ethanol content. | 2015-10-22 |
20150299736 | MODIFIED BACTERIA FOR THE PRODUCTION OF BIOALCOHOL - The present invention provides a modified bacterial strain capable of fermenting both hexose and pentose sugars for production of bioalcohol wherein a promoter of pyruvate dehydrogenase operon (PDH) is replaced with a promoter of a gene that is expressed under anaerobic conditions. The present invention further provides a method of obtaining modified bacterial strain capable of fermenting both hexose and pentose sugar for production of bioalcohol. The present invention also provides a method of fermenting lignocellulosic biomass having hexose and pentose sugar using the modified bacteria for production of biomass. | 2015-10-22 |
20150299737 | RECOMBINANT MICROORGANISMS AND METHODS OF USE THEREOF - The invention relates to methods for the production of chemical compounds, particularly but not exclusively ethanol, by microbial fermentation. Also described are genetically modified micro-organisms capable of using carbon monoxide to produce one or more products, particularly but not exclusively ethanol as a main product, and producing a reduced amount or substantially no 2,3-butanediol and/or a precursor thereof. | 2015-10-22 |
20150299738 | SULFITE PRETREATMENT FOR BIOREFINING BIOMASS - The present invention relates to a method using sulfite pretreatment to overcome recalcitrance of lignocellulose (SPORL). More specifically, it relates to a sulfite-based chemical process for pretreating biomass in solutions to reduce access barriers of enzymes to the lignocellulose, resulting in efficient conversion through enzymatic saccharification. | 2015-10-22 |
20150299739 | PROCESSES FOR PRODUCING FERMENTATION PRODUCTS - A method to produce a fermentation product comprising: providing a biomass material; pretreating the biomass material by contacting the biomass material with a solution containing at least one alpha-hydroxysulfonic acid to produce a pretreated biomass mixture containing at least one fermentable sugar; adding one or more saccharification enzymes to the pretreated biomass mixture, wherein the pretreated biomass mixture has a suitable condition for the one or more saccharification enzymes; performing enzymatic hydrolysis of cellulose by the one or more saccharification enzymes for greater than 24 hours to generate a hydrolysate; and adding at least one fermentation microorganism to the hydrolysate under a suitable condition for simultaneous saccharification and fermentation. | 2015-10-22 |
20150299740 | RECOMBINANT MICROORGANISM HAVING ENHANCED BUTANOL PRODUCING ABILITY AND METHOD FOR PRODUCING BUTANOL USING THE SAME - The present invention relates to a microorganism having an acetyl CoA biosynthesis pathway and a butyryl CoA biosynthesis pathway; the microorganism being a recombinant microorganism having an increased ability to produce butanol, wherein a pathway for converting acetyl CoA into acetate is suppressed, and a pathway for converting acetate into acetyl CoA and a pathway for converting butyryl CoA into butanol are promoted. Also, the present invention concerns a method for producing butanol by using the recombinant microorganism. | 2015-10-22 |
20150299741 | METHOD FOR CONVERSION OF AN ALKANE OR 1-ALKANOL TO A DIOL - The present invention relates to a method comprising the steps a) providing an alkane or 1-alkanol, b) contacting said alkane or 1-alkanol in an aqueous solution with a cytochrome P450 alkane hydroxylase from the CYP153 family and oxygen for at least 3 hours. | 2015-10-22 |
20150299742 | COMPOSITIONS AND METHODS FOR ENHANCING TOLERANCE FOR THE PRODUCTION OF ORGANIC CHEMICALS PRODUCED BY MICROORGANISMS - Embodiments herein generally relate to methods, compositions and uses for enhancing tolerance of production of organic acids and alcohols by microorganisms. This application also relates generally to methods, compositions and uses of vectors having one or more genetic element to increase the tolerance of organic acids or alcohols by a microorganism. Certain embodiments relate to compositions and methods of enhancing the tolerance for production of 3-hydroxypropionic acid (3-HP) by bacteria. In some embodiments, compositions and methods relate to regulating the expression of an inhibitory molecule of an enhancing gene to increase production of organic acid by bacteria. | 2015-10-22 |
20150299743 | PROCESS FOR PRODUCTION OF AN ALKYL METHACRYLATE - A process for the production of an alkyl methacrylate, particularly methyl methacrylate, is provided, in which a Baeyer-Villiger Monooxygenase enzyme is used to convert an alkylisopropenylketone substrate to the relevant alkyl methacrylate by abnormal asymmetric oxygen insertion. The invention provides a biobased route to key industrial monomers in particular for the generation of polymers such as poly methyl methacrylate. | 2015-10-22 |
20150299744 | METHODS FOR OBTAINING A GENETICALLY MODIFIED PLANT OR MICROBE AND FOR INCREASING OIL YIELD - Methods are provided for obtaining a genetically modified plant, wherein the plant exhibits an increased oil yield relative to a corresponding control plant that is not so genetically modified. The methods comprise genetically modifying a plant progenitor cell to cause a decrease in triose-phosphate isomerase activity and an increase in glycerol-3-phosphate dehydrogenase activity. The methods also comprise culturing the genetically modified plant progenitor cell to obtain the genetically modified plant. Also provided are methods for increasing oil yield, comprising genetically modifying a plant to cause, in at least one oil-producing organ or tissue of the plant, a decrease in triose-phosphate isomerase activity and an increase in glycerol-3-phosphate dehydrogenase activity. The genetic modification is carried out across more than a single generation. The genetically modified plant exhibits an increased oil yield relative to a corresponding control plant. Also provided are similar methods directed to a microbe. | 2015-10-22 |
20150299745 | COMPOSITIONS AND METHODS FOR BIOLOGICAL PRODUCTION OF FATTY ACID DERIVATIVES - The present disclosure provides compositions and methods for biologically producing fatty acid derivatives, such as fatty alcohols, from recombinant C | 2015-10-22 |
20150299746 | PROCESS FOR THE PRODUCTION OF LIPIDS FROM BIOMASS - Process for the production of lipids from biomass including at least one polysaccharide, which comprises fermentation of a biomass hydrolysate using an oleaginous microorganism and separation of oleaginous cellular biomass comprising lipids. An aqueous fraction obtained by reverse osmosis of a spent fermentation broth is recycled as a feed for growth of the oleaginous microorganism. The lipids thus obtained can be advantageously used in the production of biodiesel or green diesel which can be used as such, or in a mixture with other automotive fuels. | 2015-10-22 |
20150299747 | METHOD FOR PRODUCING TRANSESTERIFIED FAT AND/OR OIL - An object of the present invention is to provide a method in which a fat and/or oil is produced by a transesterification reaction using a lipase. Specifically, the present invention relates to a method for producing a transesterified fat and/or oil, comprising: (1) a low-temperature clay treatment step of bringing a fat and/or oil and a clay into contact with each other at 30 to 80° C. to obtain a reaction substrate; and (2) a step of subjecting the reaction substrate to a transesterification reaction in the presence of a lipase-containing composition. | 2015-10-22 |
20150299748 | FERMENTATION PRODUCT CONTAINING EQUOL-PRODUCING MICROORGANISM HAVING MAINTAINED EQUOL-PRODUCING ABILITY, AND METHOD FOR PRODUCING SAME - An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained. | 2015-10-22 |
20150299749 | PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS - The invention relates to a process for the preparation of a sugar product from ligno-cellulosic material, comprising the following steps:
| 2015-10-22 |
20150299750 | PRODUCTION OF HIGH YIELDS OF BACTERIAL POLYSACCHARIDES - The instant invention provides improved culture, fermentation and purification conditions for preparing | 2015-10-22 |
20150299751 | METHOD OF ENZYMATIC TREATMENT OF A SOLID LIGNOCELLULOSIC MATERIAL - A method of treating a solid lignocellulosic material ( | 2015-10-22 |
20150299752 | Milling Process - Process for treating crop kernels, comprising the steps of: a) soaking kernels in water to produce soaked kernels; b) grinding the soaked kernels; c) treating the soaked kernels in the presence of an effective amount of a beta-xylosidase, wherein step c) is performed before, during or after step b). | 2015-10-22 |
20150299753 | WHOLE GENOME AMPLIFICATION METHOD AND APPLICATION THEREOF - Provided are a whole genome sample amplification method, a whole genome sequencing method, and a method for determining whether an abnormal state occurs in a whole genome, a whole genome sample amplification apparatus, a whole genome sequencing device, and a system for determining whether an abnormal state occurs in a whole genome. The whole genome sample amplification method comprises: subjecting a whole genome sample to a first amplification reaction, so as to obtain a first amplification product; and subjecting the first amplification product to a second amplification reaction, so as to obtain a second amplification product. The first amplification reaction is one of the PCR-based amplification reaction and the isothermal amplification reaction, and the second amplification reaction is the other of the PCR-based amplification reaction and the isothermal amplification reaction. | 2015-10-22 |
20150299754 | STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS - The present invention relates to novel strains of | 2015-10-22 |
20150299755 | METHODS AND COMPOSITIONS FOR IMPROVING SUGAR TRANSPORT, MIXED SUGAR FERMENTATION, AND PRODUCTION OF BIOFUELS - The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell. | 2015-10-22 |
20150299756 | PROTEIN EXPRESSION ENHANCING POLYPEPTIDES - Fusion proteins comprising a protein expression enhancing polypeptide linked to a target protein binding domain and nucleic acid molecules encoding such fusion proteins are described for use in enhancing expression and/or location of a targeted protein of interest, for restoring lost functions in cells, and for treating disease. Additional fusion proteins comprising a target protein of interest modified with a fusion partner comprising a protein expression enhancing polypeptide are also disclosed. | 2015-10-22 |
20150299757 | SENSOR PROBE FOR BIO-SENSING AND CHEMICAL-SENSING APPLICATIONS - The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest. | 2015-10-22 |
20150299758 | MAGNETIC NANOPARTICLES - The present invention provides a method for producing a microscopic object comprising locating a microscopic structure, formed of an organic substance, to be used as a mold on a substrate, depositing an intended element on a surface of the organic structure by a vacuum vapor deposition method or the like, and then decomposing and thus removing the organic structure as the mold by an ultraviolet-ozone process or the like to obtain the microscopic structure formed of only an intended element. | 2015-10-22 |
20150299759 | METHOD FOR THROMBOGENICITY TESTING OF IMPLANTED MEDICAL DEVICE - A method of determining the thrombogenicity of an implantable medical device is disclosed. The implanted device is exposed in vitro to platelet rich plasma, the activity of an indicator is assayed, and the thrombogenicity is determined. | 2015-10-22 |
20150299760 | SYSTEMS AND METHODS FOR MONITORING BIOLOGICAL FLUIDS - The present disclosure relates to compositions and methods for diagnosis, research, and screening for chemicals in biological fluids (e.g., related to methanol poisoning, ethanol levels, and ethylene glycol poisoning). In particular, the present disclosure relates to point of care systems and methods for detecting formic acid or formate, ethanol, ethylene glycol, and other clinically relevant chemicals in biological fluids. | 2015-10-22 |
20150299761 | Substrates and Methods for Preparing Samples for Mass Spectrometry - A mass spectrometry substrate for performing adsorption and biological processing includes a porous silica-based material comprising a chemical adsorption material that captures analyte(s) of interest. A biologically active material incorporated into the porous silica-based material performs biological processing on the analyte(s) of interest. | 2015-10-22 |
20150299762 | FLUOROGENIC GLYCOSIDASE SUBSTRATE AND ASSOCIATED DETECTION METHOD - The invention concerns novel glycosidase substrates of formula (I): | 2015-10-22 |
20150299763 | SPLA2 CARDIOVASCULAR PROGNOSTIC AND DIAGNOSTIC MARKER - A method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, comprising: | 2015-10-22 |
20150299764 | IMMOBILISED CYCLIN-DEPENDENT KINASE 4 FUSION PROTEINS AND USES THEREOF - The present invention concerns an in vitro assay for determining the activation status of endogenous CDK4 in eukaryotic cells, said assay comprising the steps of: providing eukaryotic cells maintained in a quiescent state, said eukaryotic cells comprising a cyclin D/CDK4 fusion protein, wherein the CDK4 part of the fusion protein is present in a hypophosphorylated form; inducing proliferation of said eukaryotic cells; isolating the cyclin D/CDK4 fusion protein from said eukaryotic cells; and measuring the activation status of said isolated cyclin D/CDK4 fusion protein, thereby determining the activation stats of endogenous CDK4 in said eukaryotic cells. | 2015-10-22 |
20150299765 | LUCIFERASE BIOSENSORS FOR cAMP - A modified luciferase protein which is a sensor for molecules including cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP. | 2015-10-22 |
20150299766 | AUTOMATION OF BARRIER-BASED PLANT NUCLEIC ACID AND PROTEIN EXTRACTION - This invention is related to systems and methods for nucleic acid/protein extraction/isolation from biological samples. In particular, automated barrier-based systems for samples from plant tissues/cells are disclosed. The automated systems and methods disclosed provide reliability and high throughput specifically suitable for nucleic acid/protein extraction/isolation from plant tissues/cells. In some embodiments, the automated systems disclosed can further enhance high throughput capacity for nucleic acid/protein extraction/isolation directly from plant tissue samples. | 2015-10-22 |
20150299767 | COMPOSITIONS AND METHODS FOR NEGATIVE SELECTION OF NON-DESIRED NUCLEIC ACID SEQUENCES - The present invention provides methods, compositions and kits for the generation of next generation sequencing (NGS) libraries in which non-desired nucleic acid sequences have been depleted or substantially reduced. The methods, compositions and kits provided herein are useful, for example, for the production of libraries from total RNA with reduced ribosomal RNA and for the reduction of common mRNA species in expression profiling from mixed samples where the mRNAs of interest are present at low levels. The methods of the invention can be employed for the elimination of non-desired nucleic acid sequences in a sequence-specific manner, and consequently, for the enrichment of nucleic acid sequences of interest in a nucleic acid library. | 2015-10-22 |
20150299768 | AN IMPROVED DEVICE AND METHOD FOR SAMPLE SEPARATION - A device comprising: a capillary array of bundled micro-capillary wells; said bundle arranged into a close packed arrangement; a first end of said array forming a sample receiving surface; wherein said device is arranged to draw said sample into said capillary array through capillary action, so as to divide the sample into a plurality of sub-reactions in said wells. | 2015-10-22 |
20150299769 | METHOD FOR LYSING A FIXED BIOLOGICAL SAMPLE - A method for lysing a fixed biological sample to obtain a lysate that is suitable for direct use in a subsequent nucleic acid analysis method. The method includes contacting the fixed biological sample with an aqueous lysis composition to obtain a lysis mixture, and heating the lysis mixture at ≧85° C. to obtain the lysate. Inhibitors of the subsequent nucleic acid analysis method are depleted by contacting the fixed biological sample in the first step with at least one compound which prevents or reduces the inhibition of the subsequent nucleic acid analysis method, and/or binding inhibitors to a solid support having an anionic surface. The method is rapid, efficient, does not require the use of chaotropic salts and does not require a prior purification of nucleic acids prior to performing the subsequent analysis method. A portion of the obtained lysate can be used directly, for example, in an amplification reaction. | 2015-10-22 |
20150299770 | Methods for One Step Nucleic Acid Amplification of Non-Eluted Samples - The present invention relates to methods and kits which can be used to amplify nucleic acids with the advantage of decreasing user time and possible contamination. For easy processing and amplification of nucleic acid samples, the samples are bound to a solid support and used directly, without purification, in a nucleic acid amplification reaction such as the polymerase chain reaction (PCR). | 2015-10-22 |
20150299771 | METHODS FOR DEPLETING RNA FROM NUCLEIC ACID SAMPLES - The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation. | 2015-10-22 |
20150299772 | SINGLE-STRANDED POLYNUCLEOTIDE AMPLIFICATION METHODS - The present invention provides amplification methods for producing a population of single stranded polynucleotides from a target polynucleotide, comprising (a) extending an RNA primer in a complex comprising (i) a DNA template comprising a sequence that is complementary to the target polynucleotide, and (ii) the RNA primer, wherein the RNA primer is hybridized to the DNA template, and (b) cleaving the RNA primer with an enzyme that cleaves RNA from an RNA/DNA hybrid such that another RNA primer hybridizes to the DNA template and repeats primer extension by strand displacement. | 2015-10-22 |
20150299773 | METHODS FOR IMPROVED ISOLATION OF GENOMIC DNA TEMPLATES FOR ALLELE DETECTION - The present disclosure relates to improved methods for the isolation of genomic material and detection of disease related single nucleotide polymorphisms. In some aspects, these methods increase the total recovery of genomic DNA from buccal cell samples by improving cell lysis conditions. In other aspects, these methods allow for the reuse of patient buccal swab samples, reducing the likelihood of having to collect additional patient samples for re-testing. Finally, in some aspects, these methods increase the sensitivity of SNP detection using an improved real-time PCR assay protocol. | 2015-10-22 |
20150299774 | METHOD FOR DETERMINING THE PRESENCE OF DIARRHOEA CAUSING PATHOGENS - This invention relates to the field of detection of diarrhoea causing pathogens from patient, food or environmental samples. Particularly, the present invention provides a polymerase chain reaction (PCR) based assay method for detection of diarrhoea causing pathogens. The present invention further provides materials such as primers, primer pairs and probes for use in the method of the invention. Preferably, the method of the invention is a multiplex real-time PCR (RT-PCR) assay for rapid determination of clinically important pathogens related to traveller's diarrhoea. | 2015-10-22 |
20150299775 | PCR PRIMERS FOR DETECTION OF VIBRIO PARAHAEMOLYTICUS THERMOSTABLE DIRECT HEMOLYSIN (TDH) AND TDH-RELATED HEMOLYSIN GENES - Disclosed are PCR primers as may be utilized in detection of the genes encoding the thermostable direct hemolysin (tdh) and the TDH-related hemolysin (trh). The PCR primers can be utilized to detect the presence of pathogenic | 2015-10-22 |
20150299776 | Identification of a Person having Risk for Atherosclerosis and Associated Disease by the Person's Gut Microbiome and the Prevention of such Diseases - The present invention provides the use of metagenomics to identify a compositional or functional alteration of the gut metagenome related to atherosclerosis or atherosclerotic associated disease. Also provided are methods to identify a person having risk for atherosclerosis and associated diseases by determining the presence of specific bacterial groups or species and also metabolic functions in the person's gut microbiota and to use such information to develop a prevention or treatment strategy. | 2015-10-22 |
20150299777 | SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES - Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained. | 2015-10-22 |
20150299778 | PRIMERS, PROBES, AND METHODS FOR MYCOBACTERIUM TUBERCULOSIS SPECIFIC DIAGNOSIS - Practical and rapid methods for the diagnosis of | 2015-10-22 |
20150299779 | METHOD TO IDENTIFY M. TUBERCULOSIS - The present invention relates to a kit and a method to identify | 2015-10-22 |
20150299780 | COMPOSITIONS AND METHODS FOR DETECTION OF CLOSTRIDIUM DIFFICILE - Methods for the rapid detection of the presence or absence of | 2015-10-22 |
20150299781 | OXIDIZING AGENT FOR MODIFIED NUCLEOTIDES - This invention relates to the use of metal (VI) oxo complexes to catalyse the selective oxidation of 5hmC residues in polynucleotides to 5fC residues. This may be useful in the identification of modified cytosine residues in a population of polynucleotides comprising a sample nucleotide sequence. A first portion of the population is oxidised with a metal (VI) oxo complex and then the first portion and a second portion of said population are both treated with bisulfite. The residues in the first and second portions that correspond to a cytosine residue in the sample nucleotide sequence are identified following treatment and the identities of these residues are used to determine the modification of the cytosine residue in the sample nucleotide sequence. Methods, reagents and kits are provided. | 2015-10-22 |
20150299782 | METHODS AND MATERIALS USING SIGNALING PROBES - Methods of isolating cells or generating cell lines comprising the step of exposing the cells to signaling probes that produce a signal upon hybridization to a target sequence, as well as methods of quantifying the level of expression of an RNA of interest, methods for identifying genetic recombinational events in living cells and methods of generating a transgenic animal using the isolated cells. Methods for isolating a plurality of cells encoding a plurality of different RNAs associated with a same nucleic acid tag sequence, comprising the step of exposing the cells to a same signaling probe that produces a detectable signal upon hybridization to the same nucleic acid tag sequence, are also provided. Signaling probes and protease probes that form stem-loop structures, three-arm junction structures, and dumbbell structures may be used in the above methods. | 2015-10-22 |
20150299783 | Methods and Compositions for Incorporating Nucleotides - The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses. | 2015-10-22 |
20150299784 | MASSIVELY PARALLEL SINGLE CELL ANALYSIS - The disclosure provides for methods, compositions, and kits for multiplex nucleic acid analysis of single cells. The methods, compositions and systems may be used for massively parallel single cell sequencing. The methods, compositions and systems may be used to analyze thousands of cells concurrently. The thousands of cells may comprise a mixed population of cells (e.g., cells of different types or subtypes, different sizes). | 2015-10-22 |
20150299785 | METHOD OF MEASURING ADAPTIVE IMMUNITY - Compositions and methods for measuring adaptive immune receptor (T cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. Lymphoid (B- and T-cell) adaptive immune receptor diversity is quantified by calculating the number of uniquely rearranged. CDR3-containing immunoglobulin (Ig) or T-cell receptor (TCR) variable region-encoding genes from sample cells such as blood cells. | 2015-10-22 |
20150299786 | UNIQUELY TAGGED REARRANGED ADAPTIVE IMMUNE RECEPTOR GENES IN A COMPLEX GENE SET - Compositions and methods are disclosed for uniquely tagging each rearranged gene segment that encodes a T cell receptor (TCR) and/or an immunoglobulin (Ig), in a DNA (or mRNA or cDNA reverse transcribed therefrom) sample from lymphoid cells. These and related embodiments permit accurate, high throughput quantification of distinct TCR and/or Ig encoding sequences. Also provided are compositions and methods for quantitatively sequencing the genes that encode both chains of a TCR or Ig heterodimer in a single cell, for example, to characterize the degree of T or B cell clonality in a sample. | 2015-10-22 |
20150299787 | IMMOBILIZED BUFFER PARTICLES AND USES THEREOF - The disclosure relates to novel particle compositions and methods of making said compositions having applications in nucleic acid analysis, as well as apparatuses and systems for the same. | 2015-10-22 |
20150299788 | RNA DETECTION METHOD AND DETECTION KIT - Provided are a method and kit for detecting RNA, which allow RNA such as microRNA and messenger RNA to be detected with high sensitivity and simply, and signal amplification probes to be used in the method. Specifically, provided is a method of detecting target RNA, the method including: (A) a capturing step of capturing RNA by a capture substance for capturing the RNA; (B) a complex-for-detection forming step of subjecting the captured RNA and signal amplification probes capable of self-assembling to a reaction to form a complex for detection including the RNA, the capture substance, and a probe polymer formed from the signal amplification probes; and (C) a detecting step of detecting the probe polymer bound in the complex for detection to detect the RNA, one of the signal amplification probes including a poly(T) sequence. | 2015-10-22 |
20150299789 | COMPETITIVE MODULATION OF MICRORNAS - The present invention provides compounds and methods for competitive modulation of microRNAs. Such compounds and methods have profound effects on cells. MicroRNAs (microRNAs), are small (approximately 18-24 nucleotides in length), non-coding RNA molecules encoded in the genomes of plants and animals. In certain instances, microRNAs regulate the expression of genes by binding to the 3′-untranslated regions (3′-UTR) of specific mRNAs. More than 1000 different microRNAs have been identified in plants and animals. | 2015-10-22 |
20150299790 | NOVEL ASSAY FOR MONITORING GLUCOSE BALANCE AND OXIDATIVE STRESS - The invention relates to diagnostic and prognostic assays, particularly to methods of determining the metabolic state of a subject. More specifically, the invention provides assays and methods comprising determining the level of m RNA of uncoupling protein 2 (UCP2) specifically in platelets of the subject. The invention is useful in determining or adjusting the treatment of conditions associated with an unbalanced metabolic state manifested by elevated blood levels of glucose, reactive oxygen species (ROS) and/or free fatty acids (FFA). In particular embodiments, the assays and methods of the invention are useful in prognosing and monitoring subjects diagnosed with diabetes, particularly type II diabetes. | 2015-10-22 |
20150299791 | DNA METHYLATION BIOMARKERS OF POST-PARTUM DEPRESSION RISK - The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. In a specific embodiment, a method for identifying a likelihood of PPD in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring white blood cell type counts and DNA methylation levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises HP1BP3 and TTC9B and the white blood cell type counts comprise monocytes and non-monocytes; and (c) identifying the patient as likely to develop PPD based on the relative DNA methylation levels at the biomarker loci relative to the ratio of monocytes:non-monocytes. | 2015-10-22 |
20150299792 | ASSESSING RISK OF READING AND LANGUAGE IMPAIRMENT - Described herein are the association BV677278 (READ1) with reading disability and language impairment, as well as the synergistic interaction of DCDC2 risk haplotypes or alleles with KIAA0319 risk allele. | 2015-10-22 |
20150299793 | Genetic Alterations on Chromosomes 21Q, 6Q and 15Q and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes - Compositions and methods for the detection and treatment of T1D are provided. | 2015-10-22 |
20150299794 | Quantitative Reverse Transcription Polymerase Chain Reaction Kit for Breast Cancer Drug Screening Test and Early Diagnosis Using Tissue and Blood - A method for a breast cancer drug screening including separating a full-length RNA from a cell obtained from a tissue or blood of a suspected cancer patient; synthesizing a cDNA from the full-length RNA; performing a PCR with the synthesized cDNA by using a composition including sets of a Pair of primers and a probe, each set independently able to amplify human epidermal growth factor receptor 2 (HER2), cytokeratin 19, EpCAM, a hTERT, Ki67, vimentin, and a GAPDH. The method further includes comparing an amount of the amplification with an expression amount to a normal person. A kit for performing methodology of the invention. | 2015-10-22 |
20150299795 | CANCER-ASSOCIATED GERM-LINE AND SOMATIC MARKERS AND USES THEREOF - The invention provides methods and compositions for identifying subjects, including canine subjects, having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line allele(s) and markers and various somatic mutations. | 2015-10-22 |
20150299796 | PREDICTION OF TREATMENT RESPONSE TO JAK/STAT INHIBITOR - The invention includes, in part, a method of selecting a subject having cancer for treatment with a JAK/STAT inhibitor and a method of determining if a therapeutically effective dose of a JAK/STAT inhibitor has been administered. | 2015-10-22 |
20150299797 | COMPOSITIONS AND METHODS RELATING TO BLOOD-BASED BIOMARKERS OF BREAST CANCER - The present invention relates generally to the field of breast cancer. More specifically, the invention concerns methods and compositions useful for diagnosing treating breast cancer. | 2015-10-22 |
20150299798 | METHOD FOR CLASSIFICATION OF LIVER SAMPLES AND DIAGNOSIS OF FOCAL NODULE DYSPLASIA, HEPATOCELLULAR ADENOMA, AND HEPATOCELLULAR CARCINOMA - The present invention relates to the technical field of liver diseases, their classification and diagnosis. It provides a new method for classifying a liver sample between non-hepatocellular sample; hepatocellular carcinoma (HCC) sample with further classification into one of subgroups G1 to G6; focal nodule dysplasia (FNH) sample; hepatocellular adenoma (HCA) sample with further classification into HNF1A mutated HCA, inflammatory HCA, β catenin mutated HCA or other HCA sample; and other benign liver sample, based on determination in vitro of genes expression profiles and analysis of the expression profile using algorithms calibrated with reference samples. The invention also provides kits for the classification of liver samples, and methods of treatment of liver disease in a subject based on a preliminary classification of a liver sample of said subject. | 2015-10-22 |
20150299799 | Method for Detecting an Increased Risk or Incidence of Colorectal Cancer - The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis. | 2015-10-22 |
20150299800 | MONITORING MANTLE CELL LYMPHOMA CLONOTYPES IN PERIPHERAL BLOOD AFTER IMMUNOTRANSPLANT - The invention is directed to a method of monitoring a mantle cell lymphoma residual disease in an immunotransplant patient by post-treatment analysis of clonotype profiles from patient blood samples. In some embodiments, methods of the invention comprising steps of (a) treating a patient by immunotransplanting the patient with vaccine-primed autologous T cells; (b) obtaining a peripheral blood sample from the patient comprising B-cells and/or cell-free nucleic acids; (c) amplifying molecules of nucleic acid from the B-cells of the sample and/or cell-free nucleic acids in the sample, the molecules of nucleic acid comprising recombined DNA sequences from immunoglobulin genes; (d) sequencing the amplified molecules of nucleic acid to form a clonotype profile; and (e) determining from the clonotype profile a presence, absence and/or level of the one or more patient-specific clonotypes correlated with the mantle cell lymphoma, including phylogenic clonotypes thereof. | 2015-10-22 |
20150299801 | Techniques for Treating Acute Lymphoblastic Leukemia (ALL) - The invention is based on the discovery of certain new somatic single nucleotide substitution mutations of NT5C2 gene variants found in some Acute Lymphoblastic Leukemia (ALL) relapse subjects. Techniques include obtaining a biological sample taken from a subject having ALL, and detecting the presence or absence in the biological sample of a biomarker selected from the group consisting of an NT5C2 gene mutation, an mRNA transcribed from the NT5C2 gene mutation, or a protein encoded by the NT5C2 gene mutation. The method also includes determining that the subject has increased resistance to treatment with 6-mercaptopurine or 6-thioguanine, if the biomarker is detected. In some embodiments, the method still further includes treating the subject with a nucleoside analog other than 6-mercaptopurine or 6-thioguanine if the biomarker is detected. | 2015-10-22 |
20150299802 | Biomarker Combinations for Colorectal Tumors - The present invention relates to methods and kits for the detection of predetermined biomarkers for early diagnosis and management of cancer, and in particular, colorectal tumors. | 2015-10-22 |
20150299803 | Methods of Using Biomarkers for the Treatment of Cancer by Modulation of BCL2 Expression - The present invention relates to cancer therapies and methods of using the same. In particular, the present invention provides methods of monitoring and improving the administration of cancer therapies, wherein the cancer is mediated by the BCL2 oncogene, via markers of disease identification, disease progression, drug resistance, and/or treatment efficacy. | 2015-10-22 |
20150299804 | BIOMARKERS FOR PREDICTING CLINICAL RESPONSE OF CANCER PATIENTS TO TREATMENT WITH IMMUNOTHERAPEUTIC AGENT - Provided herein are prognostic and diagnostic methods for predicting likelihood of clinical response of a subject having cancer to treatment with an immunotherapeutic agent. Also provided herein are methods for treating a subject having cancer with an immunotherapeutic agent after determining likelihood of clinical response of the subject to such treatment. | 2015-10-22 |
20150299805 | NUCLEIC ACID DETECTION ASSAY - This invention is directed, inter alia, to methods and kits for rapid, easy and cost-effective methods of breast cancer prediction and diagnosis in inter alia, blood samples. | 2015-10-22 |