43rd week of 2011 patent applcation highlights part 42 |
Patent application number | Title | Published |
20110262857 | ELECTROPHOTOGRAPHIC TONER - An electrophotographic toner contains an electron donating color developable agent, an electron accepting color developing agent, and a polyester resin binder which is a polyester resin obtained by polycondensation of a carboxylic acid component and an alcohol component and has a crosslinked structure formed of a crosslinking component including at least either one of a trivalent or higher valent carboxylic acid and a trihydric or higher hydric alcohol, and is decolorized by heating. | 2011-10-27 |
20110262858 | TONER CONTAINING METALLIC FLAKES AND METHOD OF FORMING METALLIC IMAGE - The present invention relates to a porous toner particle with encapsulated metallic flakes. The porous particle containing metallic flakes can be useful for reproduction of a metallic hue upon fusing to a substrate, preferably golden or silvery hue, and for manufacturing of printed circuits, by a printing process, especially electrophotography. | 2011-10-27 |
20110262859 | UPPER LAYER-FORMING COMPOSITION AND RESIST PATTERNING METHOD - An upper-layer film-forming composition includes (A) a resin that is soluble in an alkaline aqueous solution, and includes a fluorine atom, and (B) a solvent component that includes (B1) a solvent having a boiling point at 101.3 kPa of 150° C. or more and a static surface tension of 23.0 mN/m or less, the upper-layer film-forming composition being used to form an upper-layer film on a photoresist film. | 2011-10-27 |
20110262860 | NOVEL DUAL-TONE RESIST FORMULATIONS AND METHODS - Dual tone photoresist formulations comprising a photoacid generator are described and employed in fabrication techniques, including methods of making structures on substrates, and more particularly, methods of making electronic devices (e.g. transistors and the like) on flexible substrates wherein two patterns are formed simultaneously in one layer of photoresist. | 2011-10-27 |
20110262861 | PHOTOSENSITIVE COMPOSITION - Photoresist compositions and methods suitable for depositing a thick photoresist layer in a single coating application are provided. Such photoresist layers are particularly suitable for use in chip scale packaging, for example, in the formation of metal bumps. | 2011-10-27 |
20110262862 | NEAR-INFRARED ABSORPTIVE LAYER-FORMING COMPOSITION AND MULTILAYER FILM - A composition comprising (A) a near-infrared absorbing dye of formula (1), (B) a polymer, and (C) a solvent is used to form a near-infrared absorptive layer. In formula (1), R | 2011-10-27 |
20110262863 | NEAR-INFRARED ABSORPTIVE LAYER-FORMING COMPOSITION AND MULTILAYER FILM - A near-infrared absorptive layer is formed from a composition comprising (A) an acenaphthylene polymer, (B) a near-infrared absorbing dye, and (C) a solvent. When a multilayer film comprising the near-infrared absorptive layer and a photoresist layer is used in optical lithography, the detection accuracy of optical auto-focusing is improved, allowing the optical lithography to produce a definite projection image with an improved contrast and succeeding in forming a better photoresist pattern. | 2011-10-27 |
20110262864 | Method of forming resist pattern and negative tone-development resist composition - A method of forming a resist pattern, including: forming a resist film on a substrate using a resist composition containing a base component (A) which exhibits decreased solubility in an organic solvent under action of an acid and an acid-generator component (B) which generates an acid upon exposure, conducting exposure of the resist film, and patterning the resist film by a negative tone development using a developing solution containing an organic solvent, wherein the base component (A) includes a resin component (A1) containing a structural unit (a0) derived from an acrylate ester containing an acid decomposable group which generates an alcoholic hydroxy group by the action of acid to thereby exhibit increased hydrophilicity. | 2011-10-27 |
20110262865 | RADIATION-SENSITIVE RESIN COMPOSITION AND POLYMER - A radiation-sensitive resin composition includes a resin and a photoacid generator. The resin includes a polymer including a first repeating unit shown by a following formula (1) and an acid-dissociable group-containing repeating unit, | 2011-10-27 |
20110262866 | EXPOSURE APPARATUS AND DEVICE MANUFACTURING METHOD - An exposure apparatus which projects exposure light from a pattern of an illuminated original onto a substrate, comprises a projection system including an optical element and configured to project the exposure light onto the substrate, an enclosure configured to enclose the projection system, and a cleaning mechanism configured to clean the optical element by irradiating the optical element with ultraviolet light under an environment in which oxygen is present within the enclosure, the cleaning mechanism including a light source configured to generate ultraviolet light, a tubular member including an exit window and configured to partially enclose an optical path between the light source and the optical element, and a regulating device configured to regulate an environment of a space inside the tubular member so that a partial pressure of oxygen becomes lower in the space inside the tubular member than in a space which is outside the tubular member. | 2011-10-27 |
20110262867 | METHOD OF CREATING AN EVALUATION MAP, SYSTEM, METHOD OF MANUFACTURING A SEMICONDUCTOR DEVICE AND COMPUTER PROGRAM PRODUCT - According to one embodiment, evaluation map creating method is disclosed. The method determines number (N) of times on changing division starting position of layout for segmenting the layout into areas M to create the map by segmenting the layout into areas m and obtaining evaluation value v corresponding to area m (P | 2011-10-27 |
20110262868 | METHOD OF DETECTING ALIGNMENT MARK AND METHOD OF MANUFACTURING PRINTED CIRCUIT BOARD - When an alignment mark does not exist within an area of an image obtained by a camera, the coordinate of the alignment mark is calculated based on an identification mark existing in the area of the image and a previously stored positional relationship between the alignment mark and the identification mark. A distance by which a long-sized base material is to be moved for causing the alignment mark to be positioned within the imaging area of the camera is calculated based on the calculated coordinate of the alignment mark, and the long-sized base material is moved by the calculated distance. | 2011-10-27 |
20110262869 | METHOD OF ALIGNING PHOTOMASK WITH BASE MATERIAL AND METHOD OF MANUFACTURING PRINTED CIRCUIT BOARD - An exposure system includes an exposure device and an image processing device. The exposure device includes a plurality of cameras. Each of the cameras is configured so as to be selectively set to a full scan mode and a partial scan mode. The camera transmits all of obtained image data in the full scan mode, and extracts part of the obtained image data and transmits the partial image data in the partial scan mode. The image processing device paratactically performs processing using the image data transmitted from the camera and processing using the image data transmitted from the camera. | 2011-10-27 |
20110262870 | PURGE RING WITH SPLIT BAFFLES FOR PHOTONIC THERMAL PROCESSING SYSTEMS - A purge ring for a photonic temperature processing system includes a first layer, a second layer, and a third layer. The first layer, the second layer and the third layer define an inner region. The first layer and the second layer define a first plenum and a first baffle. The first plenum receives a first gas that flows through the first plenum and the first baffle to the inner region. The second layer and the third layer define a second plenum and a second baffle. The second plenum receives a second gas that flows through the second plenum and the second baffle to the inner region, and wherein the second baffle is one of less restrictive and more restrictive than the first baffle. | 2011-10-27 |
20110262871 | NOVEL TARC MATERIAL FOR IMMERSION WATERMARK REDUCTION - Various lithography methods are disclosed herein. In an example, a method includes forming a resist layer over a substrate; forming a coating material layer that includes one of an acid and a chelate compound over the resist layer; and exposing the resist layer and the coating material layer to radiation, wherein during the exposing, the one of the acid and the chelate compound in the coating material layer substantially neutralizes any quencher that diffuses into the coating material layer from the resist layer. | 2011-10-27 |
20110262872 | METHOD OF FORMING RESIST PATTERN AND RESIST COMPOSITION - There are provided a method of forming a resist pattern in which a resist pattern is formed on top of a substrate by using a chemically amplified resist composition and conducting patterning two or more times, the method being capable of reducing the extent of damage, caused by the second patterning, imposed upon the first resist pattern that is formed by the first patterning; as well as a resist composition that is useful for forming the first resist pattern in this method of forming a resist pattern. The method includes forming of a first resist pattern using a resist composition containing a thermal base generator as a chemically amplified resist composition during first patterning, and then conducting a hard bake for baking the first resist pattern under a bake condition such that a base is generated from the thermal base generator, prior to the second patterning. | 2011-10-27 |
20110262873 | USE OF COMPOUNDS CONTAINING HALOGEN AND NITROGEN FOR REDUCING MERCURY EMISSIONS DURING COAL COMBUSTION - Processes and systems are provided for using bromine and/or bromide-containing compounds derived from a nitrogen-containing compound, such as ammonia, sulfamic acid, or one or more salts thereof, to reduce mercury emissions during coal combustion. | 2011-10-27 |
20110262874 | CHARCOAL STARTING SYSTEM - A device, method and system is provided for a quick, convenient, reliable, odorless and non-toxic alternative to using bagged charcoal briquettes. No harmful chemicals are used, ensuring a safe product that also will not diminish or alter the unique charcoal flavor of the foods being cooked over the charcoal briquettes. The tedious process of handling the briquettes is eliminated and no additional kindling for lighting is required. The container is placed onto the barbeque grate or other cooking surface and lights the outer package; the contained components provide sufficient heat and robust flames to ignite the briquettes within the package. | 2011-10-27 |
20110262875 | Thermo-sensing color-changeable candle - A thermo-sensing color-changeable candle includes a candle and thermo-sensing powder combined together. The thermo-sensing powder will change colors and the decorative patterns concealed at the bottom of the candle beforehand will be revealed when the candle is burnt and the temperature of the candle rises. | 2011-10-27 |
20110262876 | METHOD AND APPARATUS FOR APPLYING A MID-IR GRADED-INDEX MICROSTRUCTURE TO AN OPTICAL FIBER TIP TO ACHIEVE ANTI-REFLECTIVE PROPERTIES - A method and apparatus for applying a mid-IR graded microstructure to the end of an As2S3 optical fiber are presented herein. The method and apparatus transfer a microstructure from a negative imprint on a nickel shim to an As2S3 fiber tip with minimal shape distortion and minimal damage-threshold impact resulting in large gains in anti-reflective properties. | 2011-10-27 |
20110262877 | HEAT TREATMENT APPARATUS - A cooling chamber is provided which cools workpieces that have been heated. Cooling units are provided in the cooling chamber, and respectively include: a conveyor which simultaneously and uniserially conveys a plurality of workpieces; a mist cooling device which is disposed so as to surround the conveyance path of the conveyor and which supplies mist-like cooling liquid; and a gas cooling device which is disposed so as to surround the conveyance path of the conveyor and which supplies cooling gas. | 2011-10-27 |
20110262878 | DENTAL MATRIX - A dental matrix comprising a band with an edge for placement toward the gingival margin of a tooth to be restored, and a strip of dental floss attached to and extending along an edge of the band. In the preferred embodiment, buccal and lingual extensions are located beyond a central portion of the band along the edge. The extensions are folded over the strip of dental floss so as to secure the strip of dental floss to the edge. | 2011-10-27 |
20110262879 | Oral Irrigation and/or Brushing Devices and/or Methods - An oral hygiene device having, in one implementation, a unique, peristaltic pump water streaming or jet action; and in another implementation, a multi-headed toothbrush may also be disposed on the end of a handle on which the jet nozzle or nozzles are disposed. | 2011-10-27 |
20110262880 | METHOD FOR FILTERING AND TREATING DENTAL SOLID WASTE - The present application discloses a method of separating solid dental waste from liquid dental waste including capturing the solid dental waste in a permanently filtration unit while the liquid dental waste passes through the filtration unit, transferring the filtration unit to a central storage container; storing the central container until the central container is shipped to a handling facility; and separating the solid dental waste from the filtration unit. | 2011-10-27 |
20110262881 | DENTAL APPLIANCE FOR CONSTRAINING THE TONGUE - Aa dental appliance includes an attachment mechanism suited to attach the appliance on the teeth of a patient's upper jaw. The appliance includes a constraining mechanism linked to the attachment mechanism, where the constraining mechanism is suited to limit the movement of a central zone of the tongue and allow the anterior and lateral edges of the patient's tongue to perform movements necessary for speech and swallowing. | 2011-10-27 |
20110262882 | Natural Tooth Replacement (NTR): An Alternative to Tooth Root Canal (RCT) Therapy and Immediate Root-Form Implant Placement Into Extraction Socket - The present invention relates to the method of replacing an infected, broken, decayed tooth that would otherwise require extraction or root canal therapy with a duplicate ceramic tooth implant uncoated or coated with a series of treatments and manufactured for compatibility by obtaining CAT-SCAN images of the tooth prior to extraction or by utilizing typical ‘lost wax’ duplicating technology. The invention give the dentist an alternative to performing a root canal procedure (endodontic procedure) on an infected tooth that presents the problematic and in most cases the impossible task of eliminating all the bacteria from the tooth interior and adjacent bone. The bacteriais problematic in that it causes adjacent implants to fail and thus it is presumed to cause other distal chronic inflammatory diseases if these “foci of infections” are not removed. | 2011-10-27 |
20110262883 | Fixture mount-abutments, ball impression screw and fixture mount-abutment drivers - A dental implant fixture mount-abutment, comprising a fixture mount is a 2 to 4 mm coronal extension/metal collar at a coronal end for serving as an impression coping, temporary/permanent abutment and fixture mount, wherein the internal slots in said coronal end for receiving the fixture mount driver, wherein the driven channel in said coronal end for receiving a ball impression screw, wherein said the fixture mount has two small flat facets, located on opposite sides of the fixture mount, extended between said coronal end and circumferential groove, an abutment which is a taper cylinder body having a shoulder and a circumferential curvature, wherein the shoulder on the abutment portion is a part of the abutment, wherein the circumferential curvature is designed to avoid engaging alveolar bone so as to be easily removed later, wherein said the abutment has two large flat facets, located on opposite sides of the abutment, extended between said circumferential groove and shoulder, providing an anti-rotation feature, wherein the ferro is an circumferentially inclined surface to engage the circumferential bevel of a dental implant, increasing the stabilization between DIFMA and dental implant, wherein the 6 wave-shaped protruding features at the coronal portion of the hex-shaped root to provide additional retention, wherein the hex-shaped root of the DIFMA is a male connector for internally connecting to a dental implant. A long DIMFA is an alternative version which contains an extension portion adjacent to the fixture mount; wherein it has a circumferential indentation, two flat surfaces and two semi-circular surfaces. Both two flat surfaces and two semi-circular surfaces are located at opposite sides of the extension portion. | 2011-10-27 |
20110262884 | Soft tissue models and method of making for dental implant applications - The present invention relates to laboratory components that are used in the field of dental prosthesis and for dental implant fabrication and in particular to a spacer means such as a band, ring, or sleeve forming a soft collar which slips over the analog and slides up to the base of the set impression material near the collar of the impression coping as it emerges through the impression forming a uniform blockout around the impression coping which is recording the sub-gingival space over the top of the fixture and having a soft collar surrounding the neck of the analog insulates the top of the fixture analog from the hard stone where it couples with other components. The spacer forming the soft collar is particularly useful for orienting and indexing the modeling of dental implant restorations and to enhance and improve the fabrication process of soft tissue type models for conventional restoration techniques. It also enhances model techniques for digital scanning of cases in the laboratory. The soft collar spacer means forms a uniform blockout around the impression coping which is recording the sub-gingival space over the top of the fixture. | 2011-10-27 |
20110262885 | SURFACE MAPPING AND GENERATING DEVICES AND METHODS FOR SURFACE MAPPING AND SURFACE GENERATION - A surface mapping and generating device which has devices for the process and/or cost optimization, in particular raw material recovery devices, an automatic control of the intensity of a used laser light, devices for carrying out a calibrating procedure by evaluating overlap errors at matching points, devices for archiving especially three-dimensional data of the jaw and/or for modeling the bite position of the upper and the lower jaws, devices for the optimized preparation of at least one dental stump for the production and placement of a dental prosthesis thereon and/or devices for taking into consideration the bite position of the upper and lower jaws. It can be provided that the devices for the process and/or cost optimization are designed to ensure that two half frames showing different positions or views are evaluated, whereby preferably a pulsed laser for exposure purposes is included and/or that an image recording device, in particular a CCD chip, is arranged so as to ensure that lines, taking into account the Scheimpflug angle, are located perpendicular to the direction of travel of a measuring table. Methods according to the present invention use such devices and function correspondingly. In addition, the invention also makes available a patient data archiving system which comprises a chip card and/or decentralized data storage systems especially for dental data. | 2011-10-27 |
20110262886 | ALTERNATIVE ENERGY POWERED ELECTRONIC READER HAVING PRELOADED EDUCATIONAL DATA - A method, system and an apparatus of alternative energy powered electronic reader having preloaded educational data is disclosed. In one embodiment, a method includes converting a solar energy, through a photovoltaic cell, into an electrical current to utilize the solar energy of a sun. In addition, the method includes storing the electrical current in a battery to provide a power source to an electronic reader. The method also includes powering the electronic reader through the battery to provide an electronic content to a user. The method further includes storing the electronic content in a solid state drive in the electronic reader. The electronic content may be an educational lesson. | 2011-10-27 |
20110262887 | SYSTEMS AND METHODS FOR GAZE BASED ATTENTION TRAINING - Gaze based systems and methods are used to monitor the attention of a user. One or more images are displayed to a user on a display. It is determined that an image of the one or more images is being viewed by an eye of the user from one or more measurements received from an eyetracker. One or more modifications to the image are displayed on the display over time so as to maintain the attention of the user. Whether or not the attention of the user is maintained is determined from one or more additional measurements received from the eyetracker after the one or more modifications to the image. In various embodiments, the one or more modifications to the image include moving the image on the display. In various embodiments, the one or more modifications to the image include animating the image on the display. | 2011-10-27 |
20110262888 | SYSTEM FOR ENCOURAGING A USER TO PERFORM SUBSTANTIAL PHYSICAL ACTIVITY - A system for encouraging a user to perform substantial physical activity. The system may include sensors that may be worn by the user while the user is performing a substantial physical activity, such as running or playing basketball. The sensors may detect the magnitude of the physical activity and may transmit data regarding the physical activity to a processing system. The processing system may display a reward to encourage the user for participating in physical activity and the reward provided may be based on the physical activity of the user. | 2011-10-27 |
20110262889 | DEVICE FOR PROMOTING LEARNING OF SKILLS AND CONCEPTS AND METHOD OF USING SAME - A method and apparatus for encouraging a student to continue practicing skills until mastery of the skills is achieved. The method and apparatus present assigned exercises sequentially to a student, and evaluates the student's response. An assignment comprising a finite number of questions, a maximum number of attempts to answer each of the finite number of questions, and a required minimum number of correct answers to the finite number of questions is designed for a user. A learning device presents the user with a question from the finite number of questions that has not been attempted by the user. If the user supplies an incorrect answer to the question, the user chooses to either accept the incorrect answer, or to repeat an attempt to answer the question with new parameters. If the maximum number of attempts to answer the question is not exhausted, the learning device supplies new parameters to the question and presents the question with new parameters to the user, and the learning device reduces the available maximum number attempts to answer the question by one. | 2011-10-27 |
20110262890 | INFORMATION PROCESSING APPARATUS, QUESTIONING TENDENCY SETTING METHOD, AND PROGRAM - Disclosed herein is an information processing apparatus including: a user answer evaluation section configured to determine whether a user answer to a question selected from a plurality of questions is correct or wrong; a user answer analysis block configured to compute at least a user wrong-answer percentage by use of the user answer evaluation result; a questioning condition setting block configured to compute a degree of similarity between the plurality of questions on the basis of the user wrong-answer percentage and, at the same time, compute an evaluation value of each of the plurality of questions by use of the degree of similarity; and a question selection section configured to select a question to be set from the plurality of questions on the basis of the evaluation value and a user correct-answer percentage in one of a predetermined period and a predetermined number of questions. | 2011-10-27 |
20110262891 | Microinjection apparatus and microinjection method - A microinjection apparatus is designed to introduce the transfecting material into the transductant by inserting a minute injection needle ( | 2011-10-27 |
20110262892 | METHODS FOR DETECTION OR MEASUREMENT OF VIRUSES - A method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) an anionic surfactant and (2) an amphoteric surfactant, nonionic surfactant or protein denaturant; a virus assay method using said treating method; a method for treating a virus-containing sample, characterized by treatment of a virus-containing sample with a treatment solution containing (1) a chaotropic ion and (2) an acidifying agent; a virus assay method using said treating method; a virus assay method, characterized in that a virus antigen and a virus antibody are measured based on their binding to their probe in the presence of a surfactant with an alkyl group of 10 or more carbon atoms and a secondary, tertiary or quaternary amine, or a nonionic surfactant, or of both of them; and a monoclonal antibody and a hybridoma producing the same for carrying out said method. | 2011-10-27 |
20110262893 | SEPARATING TARGET ANALYTES USING ALTERNATING MAGNETIC FIELDS - The invention generally relates to using magnetic particles and alternating magnet fields to separate a target analyte from a sample. In certain embodiments, methods of the invention involve contacting a sample with magnetic particles including first moieties specific for a target analyte, thereby forming target/particle complexes in the sample, flowing the sample through a channel including second moieties attached to at least one surface of the channel, applying alternating magnetic fields to the flowing sample to result in target/particle complexes being brought into proximity of the surface to bind the second moieties and unbound particles remaining free in the sample, binding the target/particle complexes to the second moieties, and washing away unbound particles and unbound analytes of the sample. | 2011-10-27 |
20110262894 | VACCINE AGAINST INFECTIOUS AGENTS HAVING AN INTRACELLULAR PHASE, COMPOSITION FOR THE TREATMENT AND PREVENTION OF HIV INFECTIONS, ANTIBODIES AND METHODS OF DIAGNOSIS - A vaccine for treating and/or preventing infectious diseases where the infectious agent has at least one intracellular phase in the host during its multiplication cycle, is disclosed. The vaccine comprises at least one cryptic epitope of a cellular element that is carried along by an intracellular infectious agent as it leaves the cell, and revealed by said infectious agent. A composition for treating and/or preventing HIV infections, antibodies to a peptide of interest, and a diagnostic method, are also disclosed. | 2011-10-27 |
20110262895 | METHODS FOR THE DIAGNOSIS OF VARICELLA ZOSTER VIRUS INFECTION - The present invention relates to methods and devices for the rapid assessment of saliva for the presence of varicella zoster virus (VZV) particles. The methods and devices permit rapid, simple and cost-effective diagnosis of primary VZV infection. | 2011-10-27 |
20110262896 | SYSTEM AND METHOD FOR MULTI-ANALYTE DETECTION - The present invention provides a system and method for the simultaneous detection of multiple analytes in a sample. The detection system includes a housing that holds a reagent carousel rotatably coupled thereto. Further included in the housing is an incubator carousel rotatably coupled thereto. The housing also includes magnetic material that is associated with the incubation carousel for assisting in separation beads from reagent and wash solution. A robot, associated with the housing is configured to manipulate at least either the reagent carousel or the incubator carousel and transfer materials therebetween. Reaction vessels hold samples and reaction vessels handlers move the reaction vessels. Sample analysis is determined by at least one laser based detector. | 2011-10-27 |
20110262897 | IMAGING TECHNIQUES USING A TRIDENTATE LIGAND - The present invention relates to microscopy and, in particular, Time-resolved Emission Imaging Microscopy (TREM). The Invention relates to the use of a transition metal complex having a tridentate ligand in an imaging technique. The transition metal is preferably platinum. | 2011-10-27 |
20110262898 | Compositions, Methods, and Kits for Amplifying Nucleic Acids - The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher. Complexes comprising an enzyme inhibitor associated with an enzyme, wherein at least one enzymatic activity of the enzyme is inhibited, are also provided. Methods for amplifying a target nucleic acid while reducing undesired amplification products are disclosed, as are methods for reducing non-specific fluorescence. Kits for expediting the performance of certain disclosed methods are also provided. | 2011-10-27 |
20110262899 | FLUORESCENT LABELING OF TRANSFER RNA AND STUDY OF PROTEIN SYNTHESIS - Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system. The disclosed methods are useful in single molecule as well as in ensemble settings. | 2011-10-27 |
20110262900 | Male Reproductive Health Panel and Uses Thereof - A male reproductive health screening panel is disclosed. In some embodiments, the method comprises screening human sperm using a sperm DNA accelerated decondensation (SDAD) Test, and/or a Sperm DNA decondensation (SDD) assay, in combination with an assessment of the sperm DNA fragmentation index (DFI) of the sperm sample of interest. The method is useful in the screening and clinical management for a reproductively challenged human couple, in the assessing the reproductive health of a potential sperm donor, and in selecting an appropriate assisted reproductive technique (ART) for a reproductively challenged couple. These methods provide a decision tree that employs a patient's sperm test results in a SDAD Test, sperm DFI and/or SDD Test. An automated scoring method is disclosed for assessing sperm activity after SDAD and SDD tests. Also disclosed is an automated sperm processing protocol for both the SDD and SDAD tests. | 2011-10-27 |
20110262901 | SUSCEPTIBILITY VARIANTS FOR PERIPHERAL ARTERIAL DISEASE AND ABDOMINAL AORTIC ANEURYSM - The present invention discloses certain genetic variants as susceptibility variants for peripheral arterial disease (PAD) and abdominal aortic aneurysm (AAA). The invention relates to risk management using such variants. The invention further relates to kits for use in risk assessment of PAD and AAA. | 2011-10-27 |
20110262902 | CIS-ACTING DIVERSIFICATION ACTIVATOR AND METHOD FOR SELECTIVE DIVERSIFICATION OF NUCLEIC ACIDS - The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nucleic acid comprising introducing a genetic construct comprising the diversification activator into a recipient cell, wherein the diversification activator is linked to the target nucleic acid. | 2011-10-27 |
20110262903 | Modified Proteins and Methods of Making and Using Same - Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions. | 2011-10-27 |
20110262904 | FLUORESCENT DYES,METHODS OF SYNTHESIS AND APPLICATIONS THEREOF - The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH | 2011-10-27 |
20110262905 | KIT FOR THE OPTIMISATION OF PROTEIN SYNTHESIS/SECRETION - The invention relates to a kit to be used for the identification of a secretion cassette, which in eukaryotic cells gives rise to a higher level of synthesis/secretion of a protein of interest, the coding sequence of which being flanked by the first and the second set of genetic elements, respectively, compared to the other secretion cassettes present in the kit containing the coding sequence at the corresponding position, as well as to a method wherein the kit is used and the use of said kit, whereby the best secretion cassette will be obtained. | 2011-10-27 |
20110262906 | MICROFLUIDIC MULTIPLEXED CELLULAR AND MOLECULAR ANALYSIS DEVICE AND METHOD - A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber. | 2011-10-27 |
20110262907 | PROCECURE FOR PREPARING A PROCESSED VIRTUAL ANALYSIS IMAGE - This method includes the following steps: carrying out a processing of the specimen so as to make it possible to differentiate the pathological cells from the healthy cells of the specimen; and performing an acquisition of images of the specimen disposed on an analysis plate so as to obtain a plurality of images each representing a zone of the analysis plate, the images placed side by side forming an image of the whole of the specimen so as to create a virtual analysis plate. The method furthermore includes the following step: performing on the virtual analysis plate a processing of the images acquired so as to obtain a virtual restitution of the colors and of the intensity of the colors of the cytoplasm and/or of the nucleus, the colors and the intensity being able to be modified according to the preferences of the person in charge of the analysis. | 2011-10-27 |
20110262908 | ISOLATION OF PROTEIN FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH NUCLEIC ACIDS - Methods for isolating polypeptides and polypeptide complexes that are associated with a target nucleic acid sequence are provided. The methods comprise the steps of obtaining a sample that comprises a target nucleic acid sequence and one or more polypeptides or proteins associated with that target nucleic acid sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target nucleic acid sequence, wherein the oligonucleotide probe comprises at least one locked nucleic acid (LNA) nucleotide and wherein the oligonucleotide probe further comprises at least one affinity label (e.g. biotin); allowing the at least one oligonucleotide probe and the target nucleic acid sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label (e.g. using streptavidin-coated magnetic beads); and eluting the one or more polypeptides that are associated with the target nucleic acid sequence. Probes (e.g. with long spacer) for use in the methods of screening are also provided. | 2011-10-27 |
20110262909 | Genetic Markers for Horned and Polled Cattle and Related Methods - Embodiments of the present invention provide methods for improving desirable animal traits including the horned/polled phenotype in bovine animals. Also provided are methods for determining a dairy animal's genotype with respect to multiple markers associated with polled, fitness and/or productivity traits. The invention also provides methods for selecting or allocating animals for predetermined uses such as progeny testing or nucleus herd breeding, for picking potential parent animals for breeding, and for producing improved progeny animals. Also provided are methods for identifying genetic markers associated with polled, fitness and/or productivity traits that are in allelic association with the SNPs disclosed herein. | 2011-10-27 |
20110262910 | MARKER FOR COLON CANCER AND METHOD FOR DETECTING COLON CANCER - In embodiments the expression or methylation of the TBX5 gene is used as a marker for the presence and prognosis of colon cancer. In further embodiments methods for detecting colon cancer are disclosed as are methods for inhibiting the growth of colon cancer cells. | 2011-10-27 |
20110262911 | CORRECTING AN ASSAY IMAGE OF AN ARRAY OF SIGNALS GENERATED FROM A MULTIPLEXED HYBRIDIZATION-MEDIATED ASSAY - Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed. | 2011-10-27 |
20110262912 | METHOD FOR MEASURING DNA METHYLATION - The present invention relates to a method of measuring the content of methylated DNA in a DNA region of interest in a genomic DNA contained in a biological specimen, and so on. | 2011-10-27 |
20110262913 | MARKING - The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of the plurality of different DNA fragment types comprising a plurality of different length DNA fragments and a method in which a sample of the DNA fragment type is taken, amplified and analysed to determine the identity of the marker for an article. | 2011-10-27 |
20110262914 | METHODS AND COMPOSITIONS FOR DIAGNOSING OR MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES - Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring chronic inflammatory disease, particularly SLE infection and kits or systems containing the same are also described. | 2011-10-27 |
20110262915 | METHOD FOR PREDICTING THE ATHLETIC PERFORMANCE POTENTIAL OF A SUBJECT - A method for predicting the athletic performance potential of a subject comprising the step of assaying a biological sample from a subject for a genetic variant in linkage disequilibrium with MSTN-66493737 (T/C) SNP. The invention also provides an assay for determining the athletic performance potential of a subject. | 2011-10-27 |
20110262916 | NON-INVASIVE FETAL RHD GENOTYPING FROM MATERNAL WHOLE BLOOD - The present invention discloses methods of determining the RhD genotype of subject. In particular, the invention provides a non-invasive method of determining fetal RhD genotype from a maternal biological sample containing fetal cells. The invention also provides novel probes and primers useful in the described methods. Kits and mixtures comprising the novel probes and primers are also disclosed. | 2011-10-27 |
20110262917 | MODIFIED NUCLEOTIDES - Modified nucleotides, and methods to modify nucleotides with a moiety or label, such as biotin, that permits their detection and results in a modified nucleotide, and methods of use of the modified nucleotide in quantitative and qualitative assays. | 2011-10-27 |
20110262918 | IMPROVED NANOPARTICULATE COMPOSITIONS OF POORLY SOLUBLE COMPOUNDS - The present invention is related to a method for the quantification of one or more target ribonucleic acids in a sample comprising the steps of, (i) providing a sample comprising said one or more target ribonucleic acids, (ii) contacting said sample with a ribonucleic acid specific fluorescence dye under conditions allowing for binding of said dye to the one or more ribonucleic acids in said sample, (iii) measuring fluorescence of said RNA-bound dye in said sample, (iv) correlating said measured fluorescence to the total amount of RNA in the sample, (v) reverse transcribing said one or more ribonucleic acids, thereby creating double-stranded nucleic acids, (vi) amplifying said one or more created double-stranded nucleic acids, wherein one or more fluorescence probes specific for said one or more amplification products are present during and/or after amplification under conditions allowing for binding of said one or more probes to said one or more created double-stranded deoxyribonucleic acids in the sample, (vii) measuring fluorescence of said one or more probes bound to said one or more amplification products during and/or after the amplification reaction and correlating said measured fluorescence to the amount of target RNA sequence in the sample and (viii) normalizing the amount of target RNA sequence in the sample to the total amount of RNA in the sample. | 2011-10-27 |
20110262919 | METHOD FOR PRETREATING SPECIMEN AND METHOD FOR ASSAYING BIOLOGICAL SUBSTANCE - On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet comes close to the pipette chip. While remotely constraining with the magnet the magnetic particles carrying the nonspecific reaction factor bonded thereto, the residual liquid is discharged into a well. Thus, the removal of a contaminant contained in the specimen is completed. The thus treated specimen discharged into the well is subjected to an immunoassay. The magnetic particles carrying the antibody immobilized thereon are mixed with the treated specimen and suspended therein. The suspension is sucked up into a pipette chip and the magnetic particles carrying an antigen bonded thereto are separated by use of the magnet. The magnetic particles carrying the antigen bonded thereto are washed, mixed with an enzyme-labeling solution, which contains a second support, and suspended therein. After suspending, the magnetic particles being labeled and carrying the antigen bonded thereto are mixed with a substrate solution and subjected to the measurement of emission intensity, etc. | 2011-10-27 |
20110262920 | METHODS FOR PREDICTING SURVIVAL IN CANCER PATIENTS - A method for survival prediction in cancer patients is provided. In one embodiment, the survival prediction is determined by the presence or absence of KRAS gene region deletion and/or loss of Chromosome 12 (Ch. 12) in cancer tumor tissue. In another embodiment, the presence or absence of KRAS gene region deletion and/or loss of Ch. 12 in cancer tumor tissue is used to predict survival in non-small-cell lung cancer (NSCLC) patients. | 2011-10-27 |
20110262921 | Test for the Detection of Bladder Cancer - A diagnostic or prognostic method for detecting malignant and premalignant bladder cancer comprising the identification and quantification of an expression level of identified gene products in the body fluids of a patient and subsequently comparing the expression level of the patient to the expression level found in subjects that do not have bladder cancer. | 2011-10-27 |
20110262922 | APTAMER SANDWICH ASSAYS - The present invention provides methods for identifying the plurality of aptamers that bind to different sites of a target molecule and methods for using the same, for example, in sandwich assays. In particular, the plurality of aptamers binding to different sites of the target molecules is identified from a library of aptamers identified from the same SELEX process. | 2011-10-27 |
20110262923 | METHOD FOR THE QUANTITATIVE DETERMINATION OF THE NUMBER OF COPIES OF A PREDETERMINED SEQUENCE IN A SAMPLE - A method for the quantitative determination of the number of at least one predetermined sequence in a biological sample comprises the steps:
| 2011-10-27 |
20110262924 | MOLECULAR ASSAY FOR DIAGNOSIS OF HIV TROPISM - The invention is directed to compositions, methods and kits for HIV subtypes in a test sample, wherein target sequence are amplified. The amplified target sequences are then analyzed by any number of mass spectrometric techniques, which data are queried against a database of base composition signatures of HIV subtypes. | 2011-10-27 |
20110262925 | METHODS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE - The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample. | 2011-10-27 |
20110262926 | EXTRACTING LOW CONCENTRATIONS OF BACTERIA FROM A SAMPLE - The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1 CFU/ml of bacteria in the sample. | 2011-10-27 |
20110262927 | ANALYZING BACTERIA WITHOUT CULTURING - The invention generally relates to conducting an assay on a sample that isolates a pathogen from the sample and allows for analysis of the pathogen with minimal (i.e., at most | 2011-10-27 |
20110262928 | DISEASE MARKERS AND USES THEREOF - The present invention encompasses miRNA profiles and type-I IFN/IFNα-induced PD marker profiles in inflammatory or autoimmune disorders, such as myositis. The profiles may also be used in, for example, methods of treating patients, methods of monitoring disease progression of patients, and in diagnosing or providing a prognosis to patients having inflammatory or autoimmune disorders. | 2011-10-27 |
20110262929 | ANTI-HS6ST2 ANTIBODIES AND USES THEREOF - The present invention provides antibodies that bind to HS6ST2 proteins, pharmaceutical compositions comprising the antibodies as active ingredients, methods for diagnosing cancer using the antibodies, HS6ST2 proteins conjugated to cytotoxic agents and pharmaceutical compositions comprising the HS6ST2 proteins as active ingredients. | 2011-10-27 |
20110262930 | Screening and Treatment Methods Using IGS5 Enzymes of the Metalloprotease Family - Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes for producing such polypeptides and/or polynucleotides, screening methods for identifying compounds which stimulate or inhibit IGS5 polypeptides and/or polynucleotides, and the use of such polypeptides and/or polynucleotides in therapy of various dysfunctions, disorders or diseases, particularly cardiovascular diseases, metabolic diseases such as diabetes mellitus type II, and neurodegenerative disorders, such as Parkinson's Disease. | 2011-10-27 |
20110262931 | MAST CELL CARBOXYPEPTIDASE AS A MARKER FOR ANAPHYLAXIS AND MASTOCYTOSIS - The present invention relates to use of mast cell carboxypeptidase as a marker for anaphylaxis or mastocytosis in serum, plasma or saliva samples. Detection of elevated mast cell caroboxypeptidase in for example serum samples is proposed for reducing false negatives in relation to diagnosis of anaphylaxis and various categories of mastocytosis by picking up serum tryptase-negative cases. | 2011-10-27 |
20110262932 | COMPOSITIONS - The invention generally relates to compositions that include magnetic particles bound to pathogens in a body fluid. | 2011-10-27 |
20110262933 | COMPOSITIONS AND METHOD FOR ISOLATING MID-LOG PHASE BACTERIA - The invention generally relates to compositions and methods for isolating mid-log phase bacteria. In certain embodiments, the invention provides a magnetic particle conjugated to an antibody that includes an epitope specific for mid-log phase bacteria. | 2011-10-27 |
20110262934 | METHOD FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE USING PHOTOTRANSISTOR - Disclosed is a method for the early diagnosis of Alzheimer's disease. In the method, cells in which a biomarker characteristic of Alzheimer's disease, preferably beta-amyloid, is labeled with magnetic beads are selectively located in the channel region of a phototransistor, and a difference in photocurrent between normal cells and the cells comprising the protein biomarker labeled with magnetic beads is sensed to diagnose Alzheimer's disease at an early stage. | 2011-10-27 |
20110262935 | METHOD FOR DETECTING A PRION INFECTION - The invention relates to an in vitro method for detecting and/or titrating an unconventional transmissible agent (UTA) or a protein of pathological conformation which is a marker for the infectivity of the UTA, in a sample, comprising a step of concentrating the sample before and after digestion with a protease. | 2011-10-27 |
20110262936 | METHOD OF DETERMINING A CONCENTRATION OF ANALYTES OF INTEREST IN A SAMPLE - A method of determining a concentration of analytes of interest in a sample reaction mixture is disclosed. The method can include measuring intensities of the polarized fluorescence of at least one comparative reaction mixture containing different, known amounts of the analytes of interest, and measuring the intensities of the polarized fluorescence of a sample reaction mixture. The method can also include determining the preliminary concentrations of the analytes of interest in the sample reaction mixture by comparing the measured intensities of the sample reaction mixtures at various time points. The margin of error for the preliminary concentration of the analytes of interest in the sample can be determined at the various time points. Finally, the concentration of the analytes of interest in the sample reaction mixture can be determined by comparing the preliminary concentrations and the respective margin of error at the given time points. | 2011-10-27 |
20110262937 | T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS - The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. | 2011-10-27 |
20110262938 | Determination of the amount of hLHB core fragment in a sample from a subject and uses thereof - The present invention provides a method for predicting the likely timing of the onset of menopause for a perimenopausal female subject by determining the amount of hLHβcf in a sample from the subject comprising the steps of: (a) contacting a sample from the subject with an antibody which specifically binds to hLHβcf without substantially cross-reacting with hLH, hLHβ or hLHβcf, under conditions permitting formation of a complex between the antibody and hLHβcf; (b) measuring the amount of complex formed, so as to thereby determine the amount of hLHβcf in the sample; and (c) comprising the amount of hLHβcf in the subject's sample determined in step (b) with either (i) the amount determined for known postmenopausal female subject or (ii) the amount determined for a sample from a known premenopausal female subject, wherein an amount of hLHβcf in the sample similar to the amount of hLHβcf in the known postmenopausal sample indicates temporal proximity to the onset of menopause, and an amount of hLHβcf in the sample similar to the amount of hLHβcf in the known premenopausal sample indicates temporal distance from the onset of menopause for the subject. AS described herein amount is both concentration and pattern of measurement of concentrations in one or more consecutive urine specimens. | 2011-10-27 |
20110262939 | METHODS AND ASSAYS FOR CLASSIFYING FOODSTUFF AND/OR BEVERAGE AND/OR DIET AND/OR NUTRITION REGIMEN AND/OR MEDICAMENT IN VIEW OF AN EFFECT ON THE CARDIOVASCULAR SYSTEM - Subject of the present invention is an in vitro-method for classifying a foodstuff and/or beverage and/or diet and/or nutrition regimen and/or medicament in view of an effect on the cardiovascular system of a subject, comprising determining the relative level of one or more cardiovascular markers. | 2011-10-27 |
20110262940 | CAPILLARY FOR IMMUNOASSAY, AND CAPILLARY IMMUNOASSAY METHOD USING SAME - A capillary for an immunoassay is provided which comprises an insoluble layer of an oxidase formed on an inner wall surface of said capillary, said oxidase being conjugated to a first antibody, and a layer of a hydrophilic polymer formed on said insoluble layer, said hydrophilic polymer layer containing a second antibody conjugated to a peroxidase, wherein said first and second antibodies are capable of binding to the same antigen. | 2011-10-27 |
20110262941 | PREDICTING MORTALITY AND DETECTING SEVERE DISEASE - Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease. | 2011-10-27 |
20110262942 | OXIDIZABLE SPECIES AS AN INTERNAL REFERENCE IN CONTROL SOLUTIONS FOR BIOSENSORS - Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample. | 2011-10-27 |
20110262943 | REAGENT KIT FOR MEASURING FRESHNESS - A reagent kit for measuring freshness, which can be stored at a relatively high temperature with high storage stability, is obtained by lyophilizing reagent solutions each containing a plurality of enzymes and an enzyme protecting agent. The reagent kit includes a first reagent and a second reagent. The first reagent is obtained by drying a frozen product of a first reagent solution containing XOD, NP, an enzyme protecting agent, and a color former under reduced pressure at a temperature not higher than the glass transition temperature (Tg). The second reagent is obtained by drying a frozen product of a second reagent solution containing XOD, NP, AP, an enzyme protecting agent, and a color former under reduced pressure at a temperature not higher than the glass transition temperature (Tg). The enzyme protecting agent is sucrose and/or gelatin, and the color former develops a color by conjugation with a reaction of decomposing Hx into xanthine and uric acid by XOD. | 2011-10-27 |
20110262944 | CONSTRUCTION AND CRYSTALLIZATION OF EXPRESSION SYSTEM FOR RNA POLYMERASE PB1-PB2 PROTEIN DERIVED FROM INFLUENZA VIRUS - The present invention aims to express influenza virus RNA polymerase on a large scale, to crystallize the influenza virus RNA polymerase, and to provide a method for screening a substance capable of serving as an active ingredient in anti-influenza drugs. | 2011-10-27 |
20110262945 | GLYCOPROTEIN PRODUCTION METHOD AND SCREENING METHOD - A method for producing a glycoprotein, which is uniform in terms of functions derived from a sugar chain (e.g., a blood half-life) and physiological activities, i.e., a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure and the higher-order structure; specifically, a method for producing a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure, and the higher-order structure, includes the following steps (a) to (c): (a) folding a glycoprotein, which is uniform in terms of the amino acid sequence and the sugar chain structure; (b) fractionating the folded glycoprotein by column chromatography; and (c) collecting a fraction having a specified activity. | 2011-10-27 |
20110262946 | MONITORING A DYNAMIC SYSTEM BY LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY - The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (LC) combined with mass spectrometry (MS). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system. | 2011-10-27 |
20110262947 | Isotopically-Labeled Proteome Standards - The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis. | 2011-10-27 |
20110262948 | Methods of Quantifying Methotrexate Metabolites - The present invention provides a method for efficiently converting methotrexate polyglutamates to methotrexate in a cellular extract by contacting the cellular extract with gamma glutamyl hydrolase under conditions suitable for efficient conversion of methotrexate polyglutamates to methotrexate. | 2011-10-27 |
20110262949 | GENETIC INCORPORATION OF 3-AMINOTYROSINE INTO REDUCTASES - This invention provides reductase proteins that comprise NH | 2011-10-27 |
20110262950 | REDOX MEDIATORS - The present invention relates to ruthenium and osmium complexes of Formula [M(A) | 2011-10-27 |
20110262951 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 2011-10-27 |
20110262952 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 2011-10-27 |
20110262953 | Phosphate Limited Inducible Promoter and A Bacillus Expression System - An evolvable production strain of | 2011-10-27 |
20110262954 | SHUTTLE VECTOR BASED TRANSFORMATION SYSTEM FOR PYROCOCCUS FURIOSUS - The present invention relates to vectors for transforming archaea and to transformed archaea, and in particular to shuttle vector systems for transformation of members of the genus | 2011-10-27 |
20110262955 | METHODS FOR DETERMINING SODIUM-PROTON-EXCHANGER LIGAND EFFICIENCY - The present invention relates to methods for determining the efficiency of an ion channel ligand comprising (a) contacting a cell expressing the ion channel with (i) plasma of an animal and (ii) the ion channel ligand and (b) determining the effect of the ion channel ligand on the cell. | 2011-10-27 |
20110262956 | CO-CULTURE COMPOSITIONS AND METHODS - Co-culture compositions and methods are described for identifying agents that modulate a cellular phenotype, particularly of neurons or pancreatic beta cells are provided herein, where the methods include co-culturing differentiated cells, wherein at least one of the cell-types are derived from human induced pluripotent stem cells from a subject having or predisposed to a neurodegenerative or metabolic disorder. Co-culture compositions of differentiated cells from two different human subjects are also described. | 2011-10-27 |