44th week of 2015 patent applcation highlights part 11 |
Patent application number | Title | Published |
20150306230 | DRUG DELIVERY VEHICLES COMPRISING CELLULOSE DERIVATIVES, STARCH DERIVATIVES, AND COMBINATIONS THEREOF - A drug delivery vehicle (e.g., a patch, a pill, an intravaginal ring, and an implant) may include a polymer matrix comprising a plasticizer and at least one selected from the group consisting of: a cellulose ester, a cellulose ether, a starch ester, a starch ether, and a combination thereof. A drug may be dispersed in the polymer matrix, in another portion of the drug delivery vehicle, or both. | 2015-10-29 |
20150306231 | STABILIZED PROTEIN GEL PREPARATION - To provide a protein preparation which enables reduction of aggregation and a stable long-time preservation, in a protein preparation having a high concentration or a protein preparation susceptible to aggregation. The protein preparation is a gel preparation which is thixotropic and in which an included protein is protected from a physical or chemical stress, is inhibited from aggregation, and thereby stably exists. | 2015-10-29 |
20150306232 | HYDROGELATORS COMPRISING D-AMINO ACIDS - Described herein are compounds comprising an oligopeptide and a non-steroidal antiinflammatory agent. The compounds self-assemble into supramolecular hydrogels and can be used as topical treatments for inflammatory conditions, such as osteoarthritis. Also described herein are oligopeptides compounds made from D-amino acid residues that form supramolecular hydrogels. The compounds may be functionalized with active agents, such as anticancer therapeutic agents, antiinflammatory agents, or imaging agents, therefore providing new mechanisms for delivery of active agents. | 2015-10-29 |
20150306233 | STABLE PHARMACEUTICAL COMPOSITION - A pharmaceutical composition comprising:
| 2015-10-29 |
20150306234 | MUTEINS OF CLOTTING FACTOR Vlll - The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers. | 2015-10-29 |
20150306235 | SUGAR CHAIN-ATTACHED LINKER, COMPOUND CONTAINING SUGAR CHAIN-ATTACHED LINKER AND PHYSIOLOGICALLY ACTIVE SUBSTANCE OR SALT THEREOF, AND METHOD FOR PRODUCING SAME - To provide a carrier linker that is capable of improving the water solubility of a physiologically active substance and more quickly releasing the physiologically active substance under specific conditions without utilizing light or enzymatic cleavage. | 2015-10-29 |
20150306236 | BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF - Bolaamphiphilic compounds are provided according to formula I: | 2015-10-29 |
20150306237 | HYALURONIC ACID-ANTIOXIDANT CONJUGATES AND THEIR USES - The invention relates to hyaluronic acid (HA) compositions and HA conjugates comprising antioxidant compounds, pharmaceutical compositions thereof and their use in medical applications. | 2015-10-29 |
20150306238 | BACTERIA TARGETING NANOPARTICLES AND RELATED METHODS OF USE - The present invention relates to bacteria-targeting nanoparticles and related methods of use. In particular, the present invention relates to dendrimer nanoparticles conjugated with Vancomycin and/or Polymixin (e.g., Polymixin B, Polymixin E). In certain embodiments, such dendrimer nanoparticles are used to sequester and/or identify bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), screen liquid samples (e.g., water samples, food samples, pharmaceutical samples, blood samples, blood platelet samples, etc.) for the presence of bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), treat disorders associated with bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria), and/or identify, sequester, and remove bacteria (e.g., Gram-positive bacteria and/or Gram-negative bacteria) from a liquid sample (e.g., water sample, food sample, pharmaceutical sample, blood sample, blood platelet sample, etc.). In certain embodiments, iron oxide nanoparticles are coated with dendrimer nano-particles conjugated with Vancomycin and/or Polymixin. | 2015-10-29 |
20150306239 | Carrier-Linked Prostanoid Prodrugs - The present invention relates to carrier-linked prostanoid prodrugs of formula (I) Z | 2015-10-29 |
20150306240 | HYDROXYL-POLYMER-DRUG-PROTEIN CONJUGATES - A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric scaffold having one or more -L | 2015-10-29 |
20150306241 | COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS - Provided is a co-polymer of formula A-B-C or a pharmaceutically acceptable salt thereof, where A comprises a water soluble polymer; B comprises a matrix metalloprotease (MMP)-cleavable polypeptide; C is a chemotherapeutic drug or a derivative thereof; and A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, where the co-polymer is not cross-linked. | 2015-10-29 |
20150306242 | PROCESS FOR PREPARING STABLE ANTIBODY MAYTANSINOID CONJUGATES - The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability comprising performing the modification reaction at a high pH. The inventive processes comprise contacting a cell-binding agent with a bifunctional crosslinking reagent in a solution having a pH of 7.1 to 9 to covalently attach a linker to the cell-binding agent and thereby prepare a mixture comprising cell-binding agents having linkers bound thereto. | 2015-10-29 |
20150306243 | ANTIBODY-SN-38 IMMUNOCONJUGATES WITH A CL2A LINKER - The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of antibodies or antigen-binding antibody fragments. More preferably, the SN-38 is attached to the antibody or antibody fragment using a CL2A linker, with 1-12, more preferably 6 or less, most preferably 1-5 SN-38 moieties per antibody or antibody fragment. Most preferably, the immunoconjugate is prepared in large scale batches, with various modifications to the reaction scheme to optimize yield and recovery in large scale. Other embodiments concern optimized dosages and/or schedules of administration of immunoconjugate to maximize efficacy for disease treatment and minimize side effects of administration. | 2015-10-29 |
20150306244 | Anthracycline-Antibody Conjugates for Cancer Therapy - The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline chemotherapeutic drug. The targeting antibody and the chemotherapeutic drug are linked via a linker comprising a hydrazide moiety. | 2015-10-29 |
20150306245 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 191P4D12 PROTEINS - Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer. | 2015-10-29 |
20150306246 | MAGNETIC NANOPARTICLES, COMPOSITES, SUSPENSIONS AND COLLOIDS WITH HIGH SPECIFIC ABSORPTION RATE (SAR) - Iron oxide nanoparticles and nanocomposites with organic molecules embedded in their structure, having exceptionally high SAR values, are provided for biological, medical (for example, drug delivery, hyperthermia, etc.) and other uses. | 2015-10-29 |
20150306247 | DELPHINIDIN COMPLEX AS AN ANTIPHLOGISTIC OR IMMUNOSUPPRESSIVE ACTIVE INGREDIENT - The invention relates to a composition comprising a complex of delphinidin and a sulfoalkyl ether β-cyclodextrin for use as an antiphlogistic and/or immunosuppressive. | 2015-10-29 |
20150306248 | CHIMERIC VSV-G PROTEINS AS NUCLEIC ACID TRANSFER VEHICLES - The design and generation of a number of chimeric VSV-G (or VSV-G variants) proteins are used as transfer vehicles to enhance delivery of nucleic acids like plasmid DNA, single and double stranded DNA and RNA, and antisense oligonucleotides into human and animal cells. These chimeric VSV-G protein-nucleic acid transfer vehicles have widespread applications to deliver nucleic acids for exon skipping and gene delivery for gene replacement in human and animals. | 2015-10-29 |
20150306249 | REVERSIBLE IMMOBILIZATION AND/OR CONTROLLED RELEASE OF NUCLEIC ACID CONTAINING NANOPARTICLES BY (BIODEGRADABLE) POLYMER COATINGS - The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation. Additionally, the present invention is directed to a method of preparing these nucleic acid comprising nanoparticles coated with a (biodegradable) polymer and to a method for coating nucleic acid comprising nanoparticles by a (biodegradable) polymer on medical or diagnostic devices. | 2015-10-29 |
20150306250 | FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION - Methods of treating hemophilia A in a subject with an F8 gene mutation, wherein the F8 gene is repaired and the resultant repaired gene, upon expression, confers improved coagulation functionality to the encoded FVIII protein of the subject compared to the non-repaired F8 gene. The invention also includes methods of inducing immune tolerance to a FVIII replacement product ((r)FVIII) in a subject having a FVIII deficiency, wherein the F8 gene mutation is repaired and the repaired gene, upon expression, provides for the induction of immune tolerance to an administered replacement FVIII protein product. The invention also includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to repair the F8 gene. | 2015-10-29 |
20150306251 | ALBUMIN COMPOSITION - The present invention relates to use of albumin and a viscosity modifier, particularly a viscosity increasing agent, in a placebo. | 2015-10-29 |
20150306252 | TWO-PHOTON PROBE FOR DETECTING COPPER(II) ION AND QUANTITATIVE ESTIMATION OF COPPER(II) ION IN HUMAN TISSUE USING THE SAME - The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu | 2015-10-29 |
20150306253 | DUAL EMISSIVE METAL NANOPARTICLES AS RATIOMETRIC PH INDICATORS - In some aspects, the present disclosure provides a dual emissive pH response noble metal nanoparticle which produces a ratiometric fluorescence signal based upon changes in the pH. In another aspect, the noble metal nanoparticle may be used in bioimaging applications as well as to detect in vivo changes of pH. | 2015-10-29 |
20150306254 | COMPOSITIONS AND METHODS FOR DETECTING COMPLEMENT ACTIVATION - Provided herein, inter alia, are compositions and methods of using the same for detecting complement activation. | 2015-10-29 |
20150306255 | POLYMERS - Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described. | 2015-10-29 |
20150306256 | Lanthanide Nanoparticle Conjugates and Uses Thereof - The present disclosure is directed generally to lanthanide nanoparticle conjugates, such as gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, conjugation to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient. | 2015-10-29 |
20150306257 | PHARMACEUTICAL PREPARATION - A pharmaceutical preparation comprising at least one complexed alpha-emitting radionuclide and at least one polysaccharide biopolymer. | 2015-10-29 |
20150306258 | PLASMA STERILIZATION OF CORNEAL TISSUE - Exemplary methods of treating tissue that has been harvested for transplant are disclosed herein. An exemplary method of preparing corneal tissue for transplant includes obtaining corneal tissue that has been harvested for transplanting and exposing the corneal tissue to a plasma-activated fluid for a period of time. | 2015-10-29 |
20150306259 | PACKAGING UNIT FOR A PHARMACEUTICAL, MEDICAL, OR COSMETIC ITEM AND METHOD OF STERILIZING A PHARMACEUTICAL, MEDICAL, OR COSMETIC ITEM THAT CAN BE ARRANGED IN THE PACKAGING UNIT - A packaging unit for at least one pharmaceutical, medical, or cosmetic item is provided. The packaging unit includes a sterilizing chamber for accommodating the item and a prechamber that can be sealed repeatedly both from an exterior of the packaging unit and from the sterilizing chamber. The prechamber has a wall that has portions made of a wall material that is selectively permeability to one or more sterilizing agents. | 2015-10-29 |
20150306260 | METHOD FOR STERILIZING MEDICAL DEVICE MADE OF ESTER RESIN - A medical device made of an ester resin, such as a hollow-fiber-type blood treatment device, is put into a packaging material made of a gas-impermeable material, and, with at least a reducing gas, such as hydrogen gas, being further enclosed therein, the packaging material is hermetically sealed to provide a medical device package. The medical device package is exposed to radiation to sterilize the inside thereof. In the medical device package, an oxygen scavenger may be further enclosed. The reducing gas may be mixed with an inert gas and enclosed as a mixed gas. As a result, it becomes possible to effectively suppress the generation of by-products, such as acetic acid, from the ester resin. | 2015-10-29 |
20150306261 | DEVICE AND METHOD FOR IRRADIATING OBJECTS WITH ELECTRON BEAM - The present invention relates to an irradiation device for irradiating objects with electron beams. The irradiation device comprises at least one electron beam emitter having an electron exit window and at least one sensor device for detecting a first dose control parameter of the electron beam. The electron beam emitter is adapted to move past the sensor device such that the electron beam emitted from the electron exit window passes within a sensing area of the sensor device. The sensor device comprises more than one conductor each having a conductor surface in the sensing area of the sensor device, and the conductor surface is adapted to be exposed to electrons of the electron beam. The invention also relates to a method. | 2015-10-29 |
20150306262 | PROCESS AND RADIATOR DEVICE FOR WORT STERILIZATION BY RADIATION FOR ETHANOL PRODUCTION - A method and irradiator apparatus used for wort sterilization by radiation for production of ethanol from sugar cane, comprising a trough-like fluid duct and a radiation source for directing radiation over the flow of a fluid conducted through the duct, and application of radiation to a fluid within an apparatus for sterilization of such fluid. | 2015-10-29 |
20150306263 | Anti-Microbial Cash Drawer - The invention relates to a system, methods and apparatus for efficiently and cost-effectively preventing the transfer of microbes, such as, for example, bacteria and viruses seamlessly during commercial transactions typically occurring at a full service check-out station in a large retail store. The invention further considers the application of the methods and apparatus in other industrial disciplines where, for example, medical equipment and surgical tools may be susceptible to cross-contamination of microbes. One preferred embodiment incorporates a slidable drawer within a cash box where currency is stored, taken, or added randomly over a period of time. Especially designed lamps allow for a rapid switching means to control the time period for activating or deactivating lamps, thus regulating UV exposure. Exposure time with UVC and the orientation of the UV lamps provides complete germicidal decontamination within seconds. | 2015-10-29 |
20150306264 | Sterilization Machine for Reprocessing an Endoscope - Sterilization machine for reprocessing an endoscope comprising a fixed part and a mobile part. The fixed part comprises a first frame and a first fluid-dynamic circuit for feeding and/or discharging fluids, and provided with a plurality of first connectors. The mobile part comprises a second frame on which a tank is mounted, a lid to hermetically close the tank and a second fluid-dynamic circuit connectable to the endoscope, able to be selectively coupled removably with the first connectors to achieve the fluidic communication with the first fluid-dynamic circuit. The second frame is provided with rolling means, and the first frame and the second frame comprise guide means and anchoring means to removably anchor the first frame to the second frame. | 2015-10-29 |
20150306265 | SYSTEMS AND METHODS FOR DISINFECTING MEDICAL INSTRUMENTS - Systems and methods for disinfecting medical instruments are provided. In one embodiment, a system can include a hood to provide a clean zone, a chamber to dispose within the clean zone, and an ultrasonicator. More specifically, the chamber can include a volume and can be configured to retain a fluid and receive medical instruments. The chamber can also include a portal through which fluids enter or leave the chamber. The ultrasonicator can be used to sonicate the volume when the fluid is present. A related method of disinfecting medical instruments can be accomplished using the systems of the present disclosure. | 2015-10-29 |
20150306266 | PROCESS FOR DECONTAMINATING OR STERILIZING AN ARTICLE - This invention relates to a a process for decontaminating or sterilizing an article contaminated with spores. The process comprises contacting the spores with a liquid sterilant for a sufficient period of time to effect a desired reduction (e.g., at least a 4 log reduction) in the number of spores capable of returning to vegetative growth. The liquid sterilant may comprise water, an antimicrobial agent (e.g., peracetic acid) and a peroxide (e.g., hydrogen peroxide). | 2015-10-29 |
20150306267 | BIOPROCESS DATA MANAGEMENT - A data management system for a biological process, comprising:
| 2015-10-29 |
20150306268 | Air Freshener - The air freshener consists of a small box formed by coupling together two parts ( | 2015-10-29 |
20150306269 | UPSTREAM HYDROGEN PEROXIDE NEBULIZING SANITATION SYSTEM - Sanitation systems for treating an airstream, such as disinfection, sterilization, and/or deodorization, by ionization are disclosed. In embodiments, the air sanitation system is disclosed having an inlet and an outlet with a plenum between them. An ultraviolet (UV) light source is arranged within the plenum and provides UV light to an area of the plenum. A hydrated quad-metallic catalyst having a desiccant is disposed in the area, and a nebulizer is arranged between the inlet and the UV light source. The nebulizer can provide a nebulized agent within the plenum, and the UV light can generate reactive oxygen species, such as hydroxyl radicals, from water captured by the desiccant or from the nebulized agent. | 2015-10-29 |
20150306270 | PROCESS FOR PRODUCING TIO2 BASED PHOTOCATALYTIC COATING, THE TIO2 BASED COATING OBTAINED BY THE PROCESS AND VARIOUS ARTICLES WITH COATING APPLIED THEREON - A water soluble photocatalytic material capable of being adhered to an article by a conventional coating process is described. The photocatalytic material includes a doped metal oxide substrate capable of exhibiting photocatalytic behavior on being exposed to visible light, wherein particle size of doped metal oxide substrate ranges from about 18 nanometer (nm) to about 35 nm. Further, the photocatalytic material includes a polymeric adhesive for improving the adhering property of the doped metal oxide substrate on the article. In addition, a process for producing the water soluble photocatalytic material is described. Further, an air purifying article, such as a sheet, on which the said photocatalytic material is applied to is also described. | 2015-10-29 |
20150306271 | ADSORPTIVE PHOTO-CATALYTIC OXIDATION AIR PURIFICATION DEVICE - An air purification system formed from an adsorptive photocatalytic oxidation device and a method of regenerating the oxidation device is disclosed. The air purification system may be configured to be installed within an air duct of a central air handling system. The air purification system may also include an ultraviolet light emitted by the ultraviolet light source to break down captured volatile organic compounds into elemental carbon dioxide and water vapor, and to irradiate air moving past the ultraviolet light and surfaces to reduce contaminants. The ultraviolet light source may be positioned to expose the adsorptive photocatalytic oxidation device to ultraviolet light emitted by the ultraviolet light source to break down captured volatile organic compounds into elemental carbon dioxide and water vapor, and to irradiate air moving past the ultraviolet light to reduce contaminants. | 2015-10-29 |
20150306272 | ODOUR-INHIBITING SUPERABSORBER - Superabsorbents comprising 1,2-decanediol exhibit reduced odor formation. | 2015-10-29 |
20150306273 | MEDICAL SEALANT COMPOSITION AND METHOD OF USING SAME - A medical sealant composition and method for coupling the medical article to skin using the medical sealant composition. The medical sealant composition can include an unsaturated rubber hydrocarbon having at least one hydrosilyation-crosslinkable functional group and a crosslinking agent having at least one SiH group per molecule. The medical sealant composition can cure at 35 degrees C. in less than 20 minutes. The method can include applying the composition to one or both of a medical article and skin when the composition is in an uncured state; applying the medical article to the skin; and allowing the composition to cure to form a sealant between the medical article and the skin. | 2015-10-29 |
20150306274 | Haemostatic Material - The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures. | 2015-10-29 |
20150306275 | COMPOSITIONS FOR TREATING BONE DEFECTS - In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials. | 2015-10-29 |
20150306276 | COLLAGEN MATRIX - Methods for making a biodegradable collagen matrix having increased osteoinductivity and a biodegradable collagen matrix prepared by these methods are provided. In various embodiments, the methods include providing an acidic collagen slurry and mixing it with at least one water soluble and/or hydrophilic bioactive agent under conditions sufficient to cause the collagen slurry to self-assemble into macroscopic collagen fibers and cause the at least one bioactive agent to form a collagen matrix containing the bioactive agent. Conditions sufficient to cause the collagen slurry to self-assembly include raising the pH of the slurry to from about 5 to about a pH of 9 and/or adding bone powder, calcium phosphate, hydroxyapatite, DBM or a mixture thereof to the acidic collagen slurry in order to raise the pH from about 5 to about 9. | 2015-10-29 |
20150306277 | BIODEGRADABLE TISSUE COMPOSITION WITH BIODEGRADABLE CROSS-LINKERS - Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto compounds are described. Also described are the methods and compositions wherein the tissue is fixed using biodegradable crosslinkers. Methods and compositions for making radio-opaque tissue are also described. Methods and compositions to obtain a degradable implantable tissue-synthetic biodegradable polymer composite are also described. Compositions and methods of incorporating substantially water-insoluble bioactive compounds in the implantable tissue are also disclosed. The use of membrane-like implantable tissue to make an implantable drug delivery patch are also disclosed. Also described are the compositions and methods to obtain a coated implantable tissue. Medical applications implantable tissue such as heart valve bioprosthesis, vascular grafts, meniscus implant, drug delivery patch are also disclosed. | 2015-10-29 |
20150306278 | OSTEOINDUCTIVE DEMINERALIZED BONE IMPLANT - A bone graft delivery device is provided comprising: a porous biodegradable graft body for inducing bone growth at a surgical site, the porous biodegradable graft body having demineralized bone matrix (DBM) fibers disposed within the porous biodegradable body, and DBM powder disposed adjacent to, on or in the DBM fibers, wherein the porous biodegradable graft body facilitates transfer of cells into and out of the porous biodegradable graft body to induce bone growth at the surgical site. Methods of making the device and using the device are also disclosed. | 2015-10-29 |
20150306279 | Prosthetic device - A prosthetic device comprising at least one part made of a polymer composition [composition (C), herein after] comprising at least one part made of a polymer composition [composition (C), herein after] comprising a polymer composition [composition (C)] comprising at least one polyaryletherketone polymer [(PAEK) polymer], and at least one nitride (NI) of an element having an electronegativity (c) of from 1.3 to 2.5, as defined in <>, CRC Press, 64 | 2015-10-29 |
20150306280 | STABLE HYDROGEL COMPOSITIONS INCLUDING ADDITIVES - The present specification generally relates to hydrogel compositions and methods of treating a soft tissue condition using such hydrogel compositions. | 2015-10-29 |
20150306281 | DEVICES AND METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A NATIVE HEART VALVE, STENTED HEART VALVE OR BIOPROSTHESIS - The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis or a native valve which develops disease via the Lrp5/Wnt Pathway in the presence of elevated lipids due to elevated Low Density Lipoprotein. This invention involves dispensing a combination of medications to target inflammation and attachment of the target cell and the secondary drugs to inhibit proliferation and calcification on an elastical stent, gortex graft or valve leaflet. The combination therapy inhibits bioprosthesis and native valve calcification with improvement of the longevity of the prosthetic material including the stent, the native valve, and the gortex covering. The valve prosthesis and or gortex graft is mounted on the elastical stent or prosthesis such that the elastical stent is connected to the valve. | 2015-10-29 |
20150306282 | Bioresorbable Stent - Disclosed herein is a high strength, bioresorbable wall thickness suitable for use in an endoprosthesis such as a stent that is produced by first forming a wall thickness by melt processing or solution processing one or more bioresorbable materials into a tubular shape; drawing the shape from shorter length to an optimum longer length and reducing the diameter from a larger diameter to a smaller diameter to orient the molecular chains of the material; fabricating a stent from the tube formed of the oriented material by cutting a strut pattern in its wall thickness; covering the stent's struts with at least one coating to delay degradation of the bioresorbable material; covering the stent's struts with one or more controlled release active ingredients to minimize the risk of restenosis or other side effects; crimping the stent onto a balloon catheter assembly; delivering the stent into an anatomical lumen via percutaneous methods to a treatment location; radially expanding the stent from a smaller size to a larger size at the treatment location wherein the stent temporarily supports the anatomical lumen; and removing the catheter from the lumen. | 2015-10-29 |
20150306283 | ORTHODONTIC APPARATUS - An orthodontic apparatus includes a composite material containing cellulose nanofibers and resin. The resin is thermoplastic resin or thermosetting resin. | 2015-10-29 |
20150306284 | IMPLANTABLE MEDICAL DEVICES THAT ARE RESISTANT TO IMMUNE CELL MEDIATED SURFACE DAMAGE - Methods for protecting biomaterials comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated damage to the biomaterial. Also provided are kits for practicing these methods and the protected biomaterials. | 2015-10-29 |
20150306285 | USER INTERLOCK FOR A MEDICAL WASTE FLUID COLLECTION AND DISPOSAL SYSTEM - A medical waste fluid collection cart may include a controller for controlling one or more functions of the medical waste fluid collection cart and a memory coupled to the controller, the memory configured for storing one or more vacuum levels. The graphical user interface may be communicatively coupled to the controller and/or the memory and may be configured to allow a user to monitor and/or control one or more functions of the medical waste fluid collection cart. The graphical user interface may include a user confirmation screen to allow a user to confirm a vacuum setting. Using the confirmation screen, the user may confirm the vacuum setting using a first selection corresponding to a predetermined low vacuum level or a second selection corresponding to a previously used vacuum level. | 2015-10-29 |
20150306286 | TISSUE REMOVAL DEVICES, SYSTEMS AND METHODS - A tissue removal device includes a rigid aspiration cannula, a valve communicating with the aspiration cannula in a fluid-sealed manner, and a pneumatically-driven actuator configured for moving the valve between an open position and a closed position, wherein at the open position the valve defines an aspiration path through the aspiration cannula and the valve, and at the closed position the valve prevents vacuum from being applied at the distal tip. | 2015-10-29 |
20150306287 | Vacuum Wound Device - A system and method for a vacuum wound device. The system includes a wound vacuum device. The vacuum device includes a compressible sponge, vacuum tubing, and a delivery tube sized to house the wound vacuum device. The wound vacuum device is connected to a vacuum pump which creates and delivers the vacuum. | 2015-10-29 |
20150306288 | METHOD FOR PRESERVING PLACENTAL BLOOD - A method for preserving whole placental blood comprising introducing whole placental blood into an air barrier storage bag, storing said bag containing whole placental blood at a temperature of more than 0° C. and less than 40° C., so as to preserve the whole placental blood. | 2015-10-29 |
20150306289 | METHODS AND SYSTEMS FOR COUNTERPULSATION OF BLOOD FLOW TO AND FROM THE CIRCULATORY SYSTEM - Counterpulsation methods and systems for assisting the heart of a patient involve, for example, coordinating the operation of a pulsatile pump to suction blood from an artery through a blood flow conduit while the heart is in systole and expel the blood into the blood flow conduit and the artery while the heart is in diastole. | 2015-10-29 |
20150306290 | Smart Tip LVAD Inlet Cannula - Embodiments of the invention provide a left ventricular assist device (LVAD) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide automatic speed control. A cannula may include two or more independent sensors. One sensor may measure ventricular pressure, while another may measure ventricular volume and/or ventricular wall location. With this information an automatic control system may be configured to adjust pump speed to minimize the likelihood of ventricular collapse and maximize LVAD flow in response to physiologic demand. Typically the volume sensors are conductance sensors. Further embodiments provide LVADs that are powered by RF energy. | 2015-10-29 |
20150306291 | Percutaneous Device and Method for Promoting Movement of a Bodily Fluid - The present invention provides a minimally-invasive percutaneous device that can be positioned within the body of a subject to aid in the movement or pumping of a bodily fluid. In one embodiment, the device comprises a plurality of pump units configured to transform from a first compressed configuration where the pump units are organized in a serial arrangement into a second expanded configuration where the pump units are reorganized into a parallel arrangement. | 2015-10-29 |
20150306292 | Detachable Module for Recharging Sorbent Materials with Optional ByPass - A detachable module for optionally recharging sorbent materials, including zirconium phosphate, with an optional bypass and conduits for a sorbent cartridge. The sorbent cartridge can have one or more modules contained therein having connectors connecting each of the modules. One or more of the modules can be reusable and the sorbent materials therein recharged. | 2015-10-29 |
20150306293 | DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS - A monitoring device ( | 2015-10-29 |
20150306294 | CASSETTE FOR PUMPING A TREATMENT SOLUTION THROUGH A DIALYZER - A cassette is provided for installation in a dialysis monitor to pump a treatment solution through a dialyzer. The cassette is a unitary component with a hydraulic manifold ( | 2015-10-29 |
20150306295 | EXTRACORPOREAL BLOOD CIRCUIT WITH NON-INVASIVE PRESSURE SENSOR - Extracorporeal blood treatment apparatus ( | 2015-10-29 |
20150306296 | BLOOD OXYGENATOR - The present disclosure describes a blood oxygenator that includes a checkerboard layout of fluid (e.g., blood) and gas (e.g., oxygen) channels. When viewed as a cross-section through each of the channels of the oxygenator, the checkerboard configuration includes alternating gas and fluid channels in both the x-axis (e.g., in-plane) and in the y-axis (e.g., out-of-plane) directions. The oxygenator described herein reduces manufacturing complexity by using first, second, and third polymer layers that include asymmetrical channel designs. The channel designs include “open” gas channels, which are exposed to the ambient atmosphere. The oxygenator is placed within a pressure vessel to drive gas into each of the open gas channels, which in some implementations, negates the need for a gas manifold. | 2015-10-29 |
20150306297 | CLEANING OF BIOLOGICAL FLUID - The present invention relates to removal of protein bound deleterious substances from an extracorporeal biological fluid by changing the affinity of the substance to the protein. The invention relates to the use of displacer substances for removal of deleterious substances. The present invention also relate to a method of removal, a system, a cleaning fluid comprising the displacer substances for removal of deleterious substances. | 2015-10-29 |
20150306298 | APPARATUS FOR REMOVING PROTEIN-BOUND TOXINS FROM BLOOD PLASMA - The invention relates to an apparatus for extracorporeal removal of protein-bound toxins from blood plasma comprising a first line device, a second line device, a third line device and a fourth line device, a dialyzer or hemofilter arranged between the first line device and the second line device and/or an adsorber, means for generating a field, at least partially surrounding the first line device and/or the dialyzer or hemofilter and/or the adsorber, a controllable fluid conveyance device arranged in the first line device and/or the second line device, and at least one controllable body fluid conveyance unit arranged in the third line device and/or the fourth line device, a filter, wherein the permeate side of the filter is connected to the first line device and the second line device, and the side of the filter to be dialyzed is connected at its inlet to the third line device, which can be connected to a patient and is connected at its outlet to the fourth line device which can be connected to the patient, wherein a controllable flow of fluid through the line devices and the dialyzer or hemofilter and/or the adsorber can be generated by means of the fluid conveyance devices. | 2015-10-29 |
20150306299 | TARGET VOLUME BASED DIAPHRAGM REPOSITIONING FOR PRESSURE MEASUREMENT APPARATUS - Methods and extracorporeal blood treatment systems reposition a diaphragm of a pressure measurement apparatus (e.g., a pressure pod apparatus of an extracorporeal blood set) by, for example, controlling an air pump apparatus to move the diaphragm toward a target measuring position based on a calculated target air volume (e.g., wherein the calculated target air volume is representative of the air volume necessary to move the diaphragm to the target measuring position based at least on a monitored air pressure). For example, after the diaphragm is bottomed out or topped out, as air is added to or removed from the transducer side cavity of a pressure pod apparatus, the target air volume may be iteratively calculated until it is determined that the diaphragm is repositioned in the target measuring position. | 2015-10-29 |
20150306300 | METHODS FOR IMPLANTING SUBCUTANEOUS VASCULAR ACCESS PORTS - A method of securing an access port to a vessel can include positioning an access port adjacent to a wall of the vessel. The access port can include an implantation passageway and a guidance passageway that is connected to the implantation passageway. The implantation passageway can be open, during the positioning of the access port, at a position proximal to a location at which the implantation passageway and the guidance passageway are connected. The method can further include forming an opening in the wall of the vessel via instruments that extend through the implantation passageway. The method can include securing the access port to the vessel such that the implantation passageway is in fluid communication with an interior of the vessel via the opening in the wall of the vessel. The method can also include sealing the implantation passageway at the position proximal to the guidance passageway. | 2015-10-29 |
20150306301 | DEVICE AND METHOD FOR IDENTIFYING A MALFUNCTION IN AN EXTRACORPOREAL BLOOD CIRCULATION - Methods and systems for identifying a malfunction in the extracorporeal blood circulation of a dialysis machine are disclosed. The malfunction may be identified by detecting at least one state parameter; determining a first evaluation criterion for identifying a malfunction in the extracorporeal blood circulation (FEB); using the first evaluation criterion, making a decision with respect to the presence of a malfunction in the extracorporeal blood circulation, generating a first error signal, and monitoring the detected state parameter; determining at least one further evaluation criterion; using the at least one further evaluation criterion, making a decision with respect to the presence of a malfunction in the extracorporeal blood circulation and generating at least one further error signal; combining the first error signal and the at least one further error signal to result in a combined error signal; and triggering an alarm if the combined error signal exceeds a predetermined limit value. | 2015-10-29 |
20150306302 | SPLIT-TIP CATHETER - A catheter includes an elongate shaft having proximal and distal end portions defining a longitudinal axis, and first and second tip segments. The elongate shaft and the first and second tip segments define respective first and second lumens. Each tip segment includes a proximal portion fixed relative to the distal end of the elongate shaft, and a distal portion. Each tip segment defines a side opening in fluid communication with a respective one of the first and second lumens. Each tip segment is movable between a straight configuration in which each respective tip segment is substantially parallel to the longitudinal axis, and a curved configuration in which each tip segment has a concave portion with respect to the longitudinal axis. The side openings face each other along the concave portions. | 2015-10-29 |
20150306303 | SYSTEM AND PROCESS FOR REMOVING BODILY FLUIDS FROM A BODY OPENING - There is a process and a system for removing body fluids from a body opening. The system can comprise a container having an inflow port and an outflow port. The inflow port is coupled to a fluid conduit, the outflow port is coupled to a pump. In one embodiment, disposed in the outflow port is a coagulant agent for coagulating bodily fluids. There can be one or more filters coupled to the container as well. In one embodiment at least one filter is coupled to the outflow port to prevent coagulated bodily fluids from leaving the container and flowing towards the pump. There can also be a process which involves providing at least one coagulant in the container, wherein the coagulant for coagulation of the body fluids and storing the coagulated body fluids in the container. There is also a process for assembling the container as well which in one embodiment includes providing both a coagulant and a filter coupled to the container. The container can also include support ridges or ribs suitable to support intake ports or outflow ports or surfaces of the container. | 2015-10-29 |
20150306304 | Device and Method for Determining Information Related to a Medical Device - The invention relates to an apparatus ( | 2015-10-29 |
20150306305 | Two-Sided Flexible Clip Assembly - A device for holding an intravenous (IV) pole and a drip chamber/filter in parallel to each other includes a first clip member and a second clip member. The first clip member and the second clip member are positioned coplanar to each other. Moreover, the first clip member is connected to the second clip member. The first clip member is made of a first base section, a first left prong, a first right prong, and a first opening. Similarly, the second clip member is made of a second base section, a second left prong, a second right prong, and a second opening. If the IV pole is positioned within the first opening, the drip chamber/filter is positioned within the second opening. In order to eliminate slipping, a slip resistant coating is externally layered onto the first left prong, the first right prong, the second left prong, and the second right prong. | 2015-10-29 |
20150306306 | Fluid Delivery Device - A fluid delivery device comprises a housing having a fluid reservoir. A needle is in fluid communication with the fluid reservoir in an engaged position and out of fluid communication with the fluid reservoir in armed and storage positions. A proximal end of a biasing member is coupled to the housing and a distal end of the biasing member is configured to deliver a force to the fluid reservoir. A piston member extends through the biasing member and is coupled to the distal end of the biasing member. The piston member is fixed with respect to the housing in a locked position such that the biasing member does not deliver the force to the fluid reservoir and moveable with respect to the housing in a released position such that the biasing member delivers the force to the fluid reservoir. Transitioning the needle from the storage position to the armed position transitions the piston from the locked position to the released position. | 2015-10-29 |
20150306307 | CANNULA DEPLOYMENT MECHANISM - A cannula insertion device is disclosed. The device includes a needle carriage, a rail device on which the needle carriage is slidable, a yoke having a channel, a linkage connected to the needle carriage and extending into the channel, a torsion spring with one end connected to the linkage, and locking device for locking the torsion spring in tension and maintaining the needle carriage and the linkage in a locked position prior to activation. Upon release of the locking device, the tension of the torsion spring is released, which causes the linkage to move in the channel and slide the needle carriage along the rail device. A catheter carriage may also be provided for actuation by the linkage. | 2015-10-29 |
20150306308 | FLUID DISPENSING OR FEEDING DEVICE - A fluid dispensing device includes a container coupled between a bottle and a discharge tube for forcing the fluid to flow through the discharge tube without gravity, a base member is disposed in the container, a housing is engaged in the container and movable toward and away from the base member, a spring biased plug controls the fluid to flow out of the housing, a cap and a casing are attached to the container, a spring biased valve piece is engaged in the casing for engaging with the cap and for controlling the fluid to flow through the cap, a magnetic member is attached to the casing, and a coil is attached to the container to act with and to move the magnetic member in the container. | 2015-10-29 |
20150306309 | INFUSION DEVICE FOR IV DRUGS THAT ARE INCOMPATIBLE TO EACH OTHER - The present invention is a device and system to permit the isolation of two fluid compounds to be delivered to a patient without intermingling the two fluid compounds, yet permitting the labor saving activity of permitting a nurse or other medical staff member to hang two IV bags simultaneously. Fluid from the first IV bag inflates the barrier pressure valve and seals the system against the intrusion of the second fluid from the second IV bag until the first fluid has been fully delivered. The barrier pressure valve then unseals the system to permit the flow of fluid from the second IV bag to the patient. This implementation permits this isolation and separate delivery of two fluids without using electronics or other technology that would require a battery backup or other uninterruptible power source. | 2015-10-29 |
20150306310 | Method for Processing Infusion Data and an Infusion Pump System - A distributed infusion pump system is provided with long-term recording of the type of medication, nutrition or hydration, pump output pressure, corresponding infusion flow, infusion flow resistance, and an automatic or manual alarm in the event that thresholds applied to these parameters or their derivatives are exceeded. | 2015-10-29 |
20150306311 | Closed Tip Dynamic Microvalve Protection Device - An endovascular microvalve device for use in a vessel during a therapy procedure includes an outer catheter, an inner catheter displaceable within the outer catheter, and a filter valve coupled to the distal ends of the inner and outer catheters. The valve is constructed of a braid of elongate first filaments coupled together at their proximal ends in a manner that the first filaments are movable relative to each other along their lengths. A filter is provided to the braid formed by electrostatically depositing or spinning polymeric second filaments onto the braided first filaments. The lumen of the inner catheter delivers a therapeutic agent beyond the valve. The device is used to provide a therapy in which a therapeutic agent is infused into an organ. | 2015-10-29 |
20150306312 | INFUSION DEVICES AND RELATED METHODS AND SYSTEMS FOR REGULATING INSULIN ON BOARD - Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves determining a current amount of active fluid in the body of the user, determining a threshold amount of active fluid in the body of the user, and automatically altering operation of the infusion device to modify delivery of the fluid to the user based on a relationship between the current amount and the threshold amount. | 2015-10-29 |
20150306313 | Physiological Monitoring-Based Implantable Drug Infusion System - A system and method for physiological monitoring and regulation of a drug infusion device. The system includes an internal compact unit that is implantable in a patient having a pulmonary disorder, the internal unit encasing a power supply, a fluid reservoir, a motor pump, a digital control unit, and a radio frequency transmitter. An infusion catheter is connected to the fluid reservoir and motor pump for automatically infusing a drug into a right ventricle of the patient during a diastole phase of a cardiac cycle. The system includes an external unit for monitoring and storing a plurality of physiological parameters of the patient and for making adjustments to a drug infusion rate. | 2015-10-29 |
20150306314 | Model-Based Personalization Scheme of an Artificial Pancreas for Type I Diabetes Applications - A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications. | 2015-10-29 |
20150306315 | SYRINGE PUMP WITH REPLACEABLE SYRINGE CARTRIDGES - A syringe system ( | 2015-10-29 |
20150306316 | MEDICAMENT DELIVERY DEVICES - A medicament delivery device comprises a housing, a holder within the housing for receiving a medicament cartridge, a piston rod for driving a bung of the medicament cartridge, a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament and control means for controlling operation of the device. The device is additionally provided with a bung sensor for sensing when the piston rod is in contact with the bung and the control means is operative for advancing the drive of the piston rod towards the bung. | 2015-10-29 |
20150306317 | SYSTEMS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS - The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. The systems generally comprise a container having first and second regions and a reservoir containing the therapeutic agent. A pressure source having pressurized fluid is in selective fluid communication with at least a portion of the reservoir. An outlet tube is in fluid communication with the reservoir of the container. At least one slot is formed in a lateral surface of the outlet tube at a position between first and second ends of the outlet tube. | 2015-10-29 |
20150306318 | APPARATUS AND METHOD FOR IMPROVED MEDICATION DOSING - An apparatus and method for improving medication dosing is provided. The apparatus preferably includes a template configured to fit over a barrel of a syringe, the template having a substantially opaque exterior and at least one substantially transparent section in the substantially opaque exterior permitting a view of the syringe barrel and a distal end of a plunger within the barrel of the syringe. A method includes the steps of positioning a dosing template on a syringe, operating a plunger within the syringe, and drawing a predetermined dose of medication into the syringe. | 2015-10-29 |
20150306319 | NEEDLE MAGNETIZING ARRANGEMENT - A needle magnetizing arrangement ( | 2015-10-29 |
20150306320 | METHOD AND DEVICE FOR DIRECTING BEEHIVE AIR, AND USE AS INHALER - A device and method for directing beehive air, in particular from at least one beehive, the beehive air is sucked up via at least one suction device, is conducted through at least one through flow device and is dispensed via at least one dispensing device. Further the beehive air is directed via at least one backflow check valve. | 2015-10-29 |
20150306321 | METERED DOSE DISPENSING VALVE - A metered dose dispensing valve for dispensing metered dose volumes of an aerosol formulation from an aerosol container comprising: •a first valve body ( | 2015-10-29 |
20150306322 | Inhalation Device - The present disclosure relates to an inhalation device for delivering at least one dose of a medicament, comprising a lock-out mechanism to prevent an operation of the inhalation device when a given number of doses has been delivered. | 2015-10-29 |
20150306323 | System For Alarm-Monitoring Patients On Continuous Free Flow Oxygen Delivery Via T-Piece On Closed Tracheal Suction System - An endotracheal tube alarm apparatus includes an inner cannula having an outer mating surface, the outer mating surface having a seated first electrical conductor, and a ventilator tube having an inner mating surface slidably coupled to the outer mating surface of the inner cannula, the inner mating surface having seated second and third electrical conductors extending circumferentially about the inner mating surface and each in complementary opposition to the first electrical conductor so that the third electrical conductor is in electrical communication with the second electrical conductor through the first electrical conductor. | 2015-10-29 |
20150306324 | SELF-CONTAINED CONTINUOUS POSITIVE AIRWAY PRESSURE MASK AND METHOD OF USE - The disclosed Current Continuous Positive Airway Pressure (CPAP) machines consist of a three piece system; mask, blower housing, and a house. The present invention discloses a self-contained CPAP mask that is configured to be fitted to a wearer's face and is comprised in an embodiment of a mask base component, a blower component, a silencing component, a blower cover component, a humidification component, and a control system component. This invention improves upon current CPAP devices by eliminating the hose and blower housing, allowing for increased mobility and portability. | 2015-10-29 |
20150306325 | SYSTEM FOR PROVIDING PRESSURE PULSES TO THE AIRWAY OF A SUBJECT - A pressure generation system for a pressure support system ( | 2015-10-29 |
20150306326 | PATIENT VENTILATING AND ASPIRATING SYSTEM - A patient ventilating ( | 2015-10-29 |
20150306327 | TRACHEOSTOMA DEVICE HOLDER - A tracheostoma device holder for holding a tracheostoma device superimposed of a tracheostoma of a person is provided. The tracheostoma device holder comprises a rigid plate for attachment over a tracheostoma via a proximal side thereof, the plate being provided with a through hole, and a tubular tracheostoma device fitting, arranged circumferentially of the through hole, the tubular tracheostoma device fitting extending distally from a distal side of the plate. The plate is manufactured in a thermoplastic material, with a melting/softening temperature allowing for molding according to the local anatomic shape of the person through direct contact between the plate and the skin of the person. A method for adaptation of such tracheostoma holding device is also provided. | 2015-10-29 |
20150306328 | SPIRAL SLIT ENDOTRACHEAL TUBE - An endotracheal tube comprising a flexible hollow tube with a spiral slit traversing a substantial length of the tube. The slit has edges that separate to create an opening by which the tube may be spiral wound onto a medical device, such as a fiber optic bronchoscope, that is in use in a pharynx passage. The angle of the slit is preferably in the range of 30-60 degrees. | 2015-10-29 |
20150306329 | PRESSURE OR FLOW LIMITING ADAPTOR - An adapter for use in airway exchange procedure capable of being rapidly coupled and uncoupled to the catheter and being capable of regulating the flow of fluid delivered to the trachea of the patient. Oxygenation is received at the proximal end of the adapter and delivered to a catheter at the distal end. The adapter may include a relief valve to release excess fluid from the provided oxygenation. The adapter may also include a throttling valve to limit the flow of fluid within the valve, preventing excessive pressure or flow rate of breathable fluid to the catheter. During the procedure, the adapter and oxygenation source may be rapidly uncoupled and coupled to the catheter by a connector on the distal end of the adapter. | 2015-10-29 |