44th week of 2008 patent applcation highlights part 58 |
Patent application number | Title | Published |
20080269444 | PEG-Substituted Pyridine Ligands and Related Water-Soluble Catalysts - Amphiphilic Group VIII metathesis catalysts, as can be used in a range of polymerization reactions and other chemical methodologies. | 2008-10-30 |
20080269445 | Monocyclopentadienyl Complexes - Monocyclopentadienyl complexes in which the cyclopentadienyl system bears at least one bridged donor and at least one arylalkyl group and a catalyst system comprising at least one of the monocyclopentadienyl complexes, and also methods for preparing them, the use of the catalyst system for the polymerization or copolymerization of olefins and a process for preparing polyolefins by polymerization or copolymerization of olefins in the presence of the catalyst system and the preparation of the associated cyclopentadienyl system. | 2008-10-30 |
20080269446 | Method for Producing Carboxylate-Rich Copolymers from Monoethylenically Unsaturated Monocarboxylic and Dicarboxylic Acids and Carboxylate-Rich Copolymers Having a Low Neurtralization Degree - Partially neutralized carboxylate-rich copolymers, processes for their preparation and methods of using the same are disclosed, the copolymers comprising: monomers (A), (B), and (C); wherein monomer (A) comprises at least one monoethylenically unsaturated monocarboxylic acid, and is present in an amount of 30% to 79.99% by weight; wherein monomer (B) comprises at least one monoethylenically unsaturated dicarboxylic acid selected from the group consisting of acids corresponding to general formula I, acids corresponding to general formula II, anhydrides thereof, and other hydrolyzable derivatives thereof, and is present in an amount of 20.01% to 70% by weight: | 2008-10-30 |
20080269447 | PREPARATION METHOD OF HOLLOW PARTICLE - Disclosed is a method of preparing hollow particles comprising polymerizing a hydrophobic monomer to form a particulate resin exhibiting a number average molecular weight of from 20,000 to 500,000, dispersing the particulate resin in an aqueous medium to form a resin particle dispersion and adding thereto a hydrophobic cross-linkable monomer in an amount of from 0.1 to 50 parts by mass based on 1 part by mass of the particulate resin to polymerize the cross-linkable monomer to form hollow particles. | 2008-10-30 |
20080269448 | Photo or electron beam curable compositions - A curable composition and a process for using the curable composition within a grating-coupled waveguide (GCW) sensor are disclosed. The composition can be used for facile replication of optical components, specifically those used in a label-independent detection system where operation of the waveguide is dependent on the detailed formation of micro and nano size patterns. The photo or electron beam curable composition has low viscosity (≦500 cPs) and cures to an optically clear material with high glass transition temperature (≧70° C.), low shrinkage on cure, low outgassing, and low extractables. | 2008-10-30 |
20080269449 | METHODS FOR THE PURIFICATION OF POLYMERS - The present invention provides methods for purifying polymers. In each embodiment of the invention disclosed herein, a supercritical fluid is contacted with an organic solution that includes a polymer to be purified dissolved in an organic solvent. The supercritical fluid extracts the organic solvent from the organic solution. Impurities such as residual monomers and process solvents are removed with the organic solvent and supercritical fluid, thereby purifying the polymer. The methods of the invention are particularly suitable for use in the purification of biodegradable polymers for use in pharmaceutical applications. | 2008-10-30 |
20080269450 | Endosomolytic Poly-Beta-Aminoester Polymers - The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation. | 2008-10-30 |
20080269451 | Antimicrobial Polymers - The present invention is concerned with providing antimicrobial compounds and processes for the production thereof. More particularly, the present invention provides antimicrobial polymeric materials comprising a polymer linked to a positively charged moiety via a carboxyl group. The present invention also provides processes for the production of such antimicrobial compounds and uses therefor. | 2008-10-30 |
20080269452 | PRIMER ADHESION PROMOTORS, COMPOSITIONS AND METHODS - A composition and method for bonding to a substrate. In general applied to a substantially transparent substrate will be a primer composition that includes a reaction product prepared by the reaction of at least one isocyanate including a thiophosphate with an amino-silane, a mercapto-silane, or a combination thereof. | 2008-10-30 |
20080269453 | Method for Producing Oh-Terminal Organic Hydrogen Polysiloxanes - Hydroxyl-terminal organopolysiloxanes having diorganylsiloxy [diorganosiloxy ??] groups and Si—H groups are prepared by reacting the appropriate chlorosilanes with less than 0.5 mol water per mol of hydrolyzable chlorine in a first step and recovering gaseous HCl, and more fully hydrolyzing with additional water in a second step. | 2008-10-30 |
20080269454 | Linear thermoplastic polyurethanes and method of fabricating the same - A linear thermoplastic polyurethane is provided. The linear thermoplastic polyurethane is prepared by starting materials of a difunctional hydrophilic polyether-polyol, 4,4-methylene bisphenyl diisocyanate (MDI) and a difunctional aliphatic polyester-polyol, wherein the starting materials of the linear thermoplastic polyurethane have an NCO:OH ratio of about 0.9:1-1.2:1. The invention also provides a method of fabricating the linear thermoplastic polyurethane. | 2008-10-30 |
20080269455 | Process for Production of Polybenzazole Polymer and the Polymer - PROBLEMS The present invention relates to a process for producing a polybenzoxazole polymer and provides a process for producing the polybenzoxazole polymer within a short reaction time.
| 2008-10-30 |
20080269456 | MULTIFUNCTIONAL CVD COATINGS - Multifunctional reactive polymers created by chemical vapor deposition (CVD) and methods of making such polymeric systems are provided. Such polymers provide multifunctional surfaces which can present two or more different molecules (e.g. biological ligands) in controlled ratios. Polymers may include compositional gradients allowing attached ligands to be presented as continuous gradients across a surface. The polymer compositions are modularly designable and applicable to a wider range of applications, including biomedical devices and diagnostic systems. | 2008-10-30 |
20080269457 | Process For Producing Polyimide Fine Particle - A process for producing polyimide fine particles that involves subjecting a polyamic acid solution to a thermal imidization process to directly produce polyimide fine particles. In the process, relatively monodisperse, non-aggregating fine polyimide particles can be directly obtained without using thermal imidization catalysts that are difficult to remove from the reaction mixture or without using an azeotropic solvent to remove the water produced. | 2008-10-30 |
20080269458 | POLYIMIDE AND LIQUID CRYSTAL ALIGNMENT FILM THEREOF - The present invention provides a polyimide having the formula (II) formed by reacting a dianhydride with the diamine having the formula (I). The polyimide provided by the present invention serves as a material for preparing the liquid crystal aligning film, wherein the liquid crystal aligning film could achieve the pre-tilt angle of 88-90° by containing only less than 5% of the diamine having the formula (I), which could highly lower down the manufacturing cost. | 2008-10-30 |
20080269459 | Process for the Preparation of a Dicarboxylic Acid - A process for the preparation of a saturated dicarboxylic acid, comprising the steps of (a) contacting a conjugated diene with carbon monoxide and water to obtain a mixture containing an ethylenically unsaturated acid product and one or more reversible adducts of the conjugated diene and the ethylenically unsaturated acid; and (b) reacting the ethylenically unsaturated acid product further with carbon monoxide and water to obtain the dicarboxylic acid, wherein step (a) and (b) are performed in the presence of a catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand, and wherein in step (a) the water concentration is maintained at a range of from 0.001 to less than 3% by weight of water, calculated on the overall weight of the liquid reaction medium, and wherein in step (b) the water concentration is maintained at a range of from 3% to 50% by weight of water, calculated on the overall weight of the liquid reaction medium. | 2008-10-30 |
20080269460 | Stress Relaxation in Crosslinked Polymers - The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. | 2008-10-30 |
20080269461 | Polymeric Carbazole Compounds - A polymeric carbazole compound comprising a monomer unit of formula (I): is disclosed, wherein x and y are equal to zero or 1, and n is an integer equal to or larger than zero. P represents a phenyl group, and C | 2008-10-30 |
20080269462 | Peptide inhibitors of HIV entry - Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to demonstrate their ability to serve as potent anti-HIV therapeutic molecules and thus, as therapeutic molecules or drugs. | 2008-10-30 |
20080269463 | Tropoelastin Isoforms and Used Thereof - This disclosure provides new isoforms of tropoelastin. The disclosure further provides methods for making and using these isoforms, alone or in combination with each other or other isomers, such as in the production of biomaterials. | 2008-10-30 |
20080269464 | COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCTE ACTIVITY - The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies B7 family member B7x as interacting with BTLA to attenuate lymphocyte activity. Methods and compositions for modulating BTLA-mediated negative signaling and interfering with the interaction of BTLA and B7x for therapeutic, diagnostic and research purposes are also provided. | 2008-10-30 |
20080269465 | BIOLOGICAL PRODUCTS - There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα. | 2008-10-30 |
20080269466 | Modified Antibody Fragments - The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region. | 2008-10-30 |
20080269467 | Anti-IL-17 Antibodies - Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders. | 2008-10-30 |
20080269468 | Devices and Methods for Integrated Continuous Manufacturing of Biological Molecules - The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration. | 2008-10-30 |
20080269469 | Method of Separating Protein - It is intended to provide a method whereby a protein can be separated and purified at a high accuracy by a convenient procedure. A sample containing the desired protein is brought into contact with an ion exchanger under first conditions at a high ionic strength and at pH value not in the vicinity of the isoelectric point of the desired protein. Next, the component adsorbed by the ion exchanger is eluted under second conditions at a lower ionic strength than in the first conditions and at a pH value closer to the isoelectric point of the desired protein than in the first conditions. | 2008-10-30 |
20080269470 | Bridged Bi-Aromatic Ligands, Catalysts, Processes For Polymerizing And Polymers Therefrom - New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/olefin copolymers, where such olefins are for example, 1-octene, propylene or styrene. The catalysts also polymerize propylene into isotactic polypropylene. | 2008-10-30 |
20080269471 | NUCLEIC ACID SEQUENCES ENCODING ZINC FINGER PROTEINS - Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants. | 2008-10-30 |
20080269472 | Nucleic acid constructs encoding cell growth and adhesion factors and cells expressing them - The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells genetically altered to express or over-express both cell proliferation growth factor(s) and cell adhesion factor(s). In addition, the present invention relates to nucleic acid constructs and nucleic acid construct systems that encode the cell adhesion and cell proliferation growth factors that are used to transfect/transform the cells so that they can express the factors. | 2008-10-30 |
20080269473 | Method - A method of producing a replication defective retrovirus comprising transfecting a producer cell with the following: iii) a retroviral genome; iv) a nucleotide sequence coding for retroviral gag and pol proteins; and iii) nucleotide sequences encoding other essential viral packaging components not encoded by the nucleotide sequence of (ii); characterised in that the nucleotide sequence coding for retroviral gag and pol proteins is codon optimised for expression in the producer cell. | 2008-10-30 |
20080269474 | Novel shRNA molecules and methods of use thereof - The present invention relates to certain novel shRNA molecules and methods of use thereof. According to certain embodiments of the present invention, methods for reducing the expression level of a target gene are provided. Such methods generally comprise providing a cell with one or more precursor nucleic acid sequences that encode two or more RNA molecules. A first RNA molecule comprises a double stranded sequence, which includes a guide strand sequence that is complementary to a portion of an mRNA transcript encoded by the target gene. In addition, a second RNA molecule comprises a second double stranded sequence, which includes a second guide strand sequence that is partially complementary to a portion of the mRNA transcript encoded by the target gene. Preferably, the second guide strand sequence comprises one or more bases that are mismatched with a nucleic acid sequence of the mRNA transcript encoded by the target gene. | 2008-10-30 |
20080269475 | Sorbent for Nucleic Acids, Comprising Acid-Activated Layer Silicate - The invention relates to a method for removing or recovering at least one nucleic acid molecule from an aqueous or alcoholic medium with the aid of a sorbent, where the sorbent includes at least one acid-activated sheet silicate, to a composition comprising the aforementioned sorbent, and to the preferred uses thereof. | 2008-10-30 |
20080269476 | Molecules and methods for nucleic acid sequencing - The invention provides molecules and methods for nucleic acid synthesis reactions useful in sequencing-by-synthesis processes. | 2008-10-30 |
20080269477 | Solvent System Based on Molten Ionic Liquids, Its Production and Use for Producing Regenerated Carbohydrates - A solution system for biopolymers in the form of carbohydrates based on a molten ionic liquid, additives optionally being contained in the solution system, is described. This solution system contains a protic solvent or a mixture of several protic solvents, and in the case where the protic solvent is solely water, this is present in the solution system in an amount of more than about 5 wt. %. Carbohydrates can be incorporated into the solution system, in particular in the form of starch, cellulose and derivatives thereof, and it can then be used for regeneration of the carbohydrates contained therein. A particularly advantageous process for the preparation of the solution system containing the carbohydrates and for the preparation of regenerated carbohydrates, in particular in the form of regenerated cellulose fibers, is moreover described. The invention accordingly also provides such spun fibers as are distinguished in that they are non-fibrillating. The invention offers in particular economic advantages over the systems of the prior art. | 2008-10-30 |
20080269478 | Method for synthesizing sucrose-6-acetic ester - The present invention discloses a method of synthesizing sucrose-6-acetic ester, comprising the following steps: adding sucrose into a polar aprotic solvent, and stirring the solvent to dissolve it, then generate a suspension solution of sucrose; adding a acetylation agent acetylnitrile into said suspension solution and stirring the solution; adding water into the aforesaid reaction solution, and then concentrating it to generate a concentrated product; adding a crystalline solvent into the concentrated product, stirring to dissolve it, and depositing for crystallization, then filtering and drying it to get a product of sucrose-6-acetic ester. The benefit of the present invention is that the method of synthesizing sucrose-6-acetic ester has simple operation, mild reaction condition, high selectivity, high yield, and is suitable for industrial production. | 2008-10-30 |
20080269479 | Process for Isolation of Macrolide Compounds - Although macrolide compounds are insoluble in water, surprisingly high part of the product was found in the liquid phase of the fermentation broth. Therefore, processing the entire fermentation broth, i.e. the suspension obtained by cultivation of a microorganism producing the required macrolide compound, is highly advisable. This invention teaches a method of processing the entire fermentation broth using cheap and environmentally acceptable solvents. | 2008-10-30 |
20080269480 | Process for the Preparation of 10,11-Dihydro-10-Oxo-5H-Dibenz[B,F] Azepine-5-Carboxamide - A process for preparing 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide, compound of formula (I), said process comprising a. reacting compound of formula (Ivb) with alkali metal methoxide to yield compound of formula (II); and b. converting compound of formula (II) to compound of formula (I). | 2008-10-30 |
20080269481 | Compounds and methods for the treatment or prevention of Flavivirus infections - Compounds represented by formula: | 2008-10-30 |
20080269482 | Use of Rylene Derivatives as Photosensitizers in Solar Cells - Use of rylene derivatives I | 2008-10-30 |
20080269483 | Production of bepromoline - A process for the preparation of a compound of formula (Ia): | 2008-10-30 |
20080269484 | Metallic Compound and Organic Electroluminescence Device Comprising the Same - The present invention relates to a light emitting metallic compound of Chemical Formula 1 and an organic electroluminescence device including the compound. In the Chemical Formula 1, M is selected from Ir, Pt, Rh, Re, and Os, and m is 2, provided that m is 1 when M is Pt. | 2008-10-30 |
20080269485 | FLUORINATED DYES AND THEIR USE IN ELECTROPHORETIC DISPLAY DEVICES - This invention relates to process for preparing fluorinated dyes selected from the group consisting of compounds of the general formulae (I) and (III) and mixtures thereof by reacting the corresponding compounds which do not have R | 2008-10-30 |
20080269486 | Reconfigurable molecules and molecular switches, sensors, and dyes employing the same - Various embodiment of the present invention are directed to organic molecules that are reconfigurable under application of an external electric field. One organic molecule embodiment of the present invention has the structure: | 2008-10-30 |
20080269487 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS - The invention concerns quinazoline derivatives of Formula (I) wherein each of Q | 2008-10-30 |
20080269488 | Novel crystalline forms of gatifloxacin - Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, and methods for their preparation. | 2008-10-30 |
20080269489 | Pyroglutamate Salts and Their Use in the Optical Resolution of Intermediates for the Synthesis of Dextrocetirizine and Levocetirizine - The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine. | 2008-10-30 |
20080269490 | Method for Asymmetric Hydrosilylation of Ketones - Method of asymmetrically hydrosilylating substrates using catalysts having a ligand of the compound of the formula (I) | 2008-10-30 |
20080269491 | Organometallic Materials for Optical Emission, Optical Absorption, and Devices Including Organometallic Materials - A near infrared phosphorescent organometallic complex includes a cyclometalating ligand and a transition metal. The cyclometalating ligand includes a fused aromatic ring structure with carbon atoms, and a heteronuclear aromatic ring with a nitrogen atom. The transition metal is bonded to the nitrogen atom in the heteronuclear aromatic ring and one of the carbon atoms in the fused aromatic ring structure. The heteronuclear ring can be part of the fused aromatic ring. The organometallic complex is capable of phosphorescent emission with maximum emission intensity occurring at a wavelength in a range from about 650 nm to about 2000 nm. | 2008-10-30 |
20080269492 | Ionic Compound - The invention relates to novel ionic compounds with low risk of combustion, more particularly, ionic compounds represented by the general formula (I): (NPR | 2008-10-30 |
20080269493 | Crystalline forms of topotecan hydrochloride and processes for making the same - Novel crystalline forms of topotecan hydrochloride and processes of making the same are disclosed. | 2008-10-30 |
20080269494 | Process for the Preparation of Alpha-Aryl-Alpha-Piperid-2-Yl-Acetamides and the Acid Hydrolysis Thereof -
A process for the preparation of -aryl-piperid-2-yl-acetamides of formula (I) in which Ar is as defined in the disclosure, by catalytic reduction of α-aryl-α-pyridin-2-yl-acetamides (II) with rhodium catalysts. Acetamides of formula (II) can subsequently by hydrolysed to the corresponding arylacetic acids, e.g. ritalinic acid, a direct precursor of methylphenidate. | 2008-10-30 |
20080269495 | Process for Preparation of Piperidine Carboxylic Acid - A process for preparing pure tiagabine, which is a piperidine carboxylic acid compound, via pharmaceutically acceptable salts of tiagabine ester is provided. Also, L(+) tartaric acid, oxalic acid and dibenzoyl L(+) tartaric acid salts of tiagabine esters are provided. Further, process for preparing acid addition salts of tiagabine esters is provided. | 2008-10-30 |
20080269496 | Method for Producing Optically Active Hydroxymethylated Compounds - The present invention presents a catalyst that allows asymmetric hydroxymethylation reactions to progress with excellent asymmetric selectivity and a production method for optically active hydroxymethylated compounds using the catalyst. Optically active hydroxymethylated compounds are obtained with excellent asymmetric selectivity by using a catalyst obtained by mixing chiral ligands (for example, chemical formula 4) | 2008-10-30 |
20080269497 | Hydrates of Optionally Substituted 2-(2-Pyridinyl) Methylthio-1H-Benzimidazoles and Process for the Production Thereof - The invention relates to crystals from optionally substituted 2-(2-pyridinyl)methylthio-1H-benzimidazole hydrates and to a method for the production thereof. | 2008-10-30 |
20080269498 | THERAPEUTIC SUBSTITUTED LACTAMS - Therapeutic compounds, compositions, medicaments, and methods are disclosed herein. | 2008-10-30 |
20080269499 | CRYSTALLINE FORMS AND PROCESS FOR PREPARING SPIRO-HYDANTOIN COMPOUNDS - A process is provided for preparing spiro-hydantoin compounds of the formula II | 2008-10-30 |
20080269500 | Process for the Preparation of 4-Aminopyrazole Derivatives - Processes for the preparation of 4-aminopyrazole and derivatives thereof, such as those of formula (C), which are useful as intermediates in the preparation of pharmaceutical compounds; to certain compounds used in these processes; and to processes for the preparation of said compounds. | 2008-10-30 |
20080269501 | Synthesis of Phosphono-Substituted Porphyrin Compounds for Attachment to Metal Oxide Surfaces - A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described. | 2008-10-30 |
20080269502 | Process for the preparation of macrocyclic compounds - The present invention relates to a new process for the preparation of diene compounds of the | 2008-10-30 |
20080269503 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 2008-10-30 |
20080269504 | Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof - Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof. | 2008-10-30 |
20080269505 | Processes for preparing darifenacin hydrobromide - The invention encompasses processes for the preparation of darifenacin hydrobromide. | 2008-10-30 |
20080269506 | Chemical amplification type resist composition - The present invention provides a sulfonium salt of the formula (Ia) | 2008-10-30 |
20080269507 | Methods for Oxidizing Organic Compounds - A method oxidizes an organic compound with oxygen in the presence of a catalyst, in which the catalyst contains a N-hydroxy- or N-(substituted oxy)-imide compound derivable from at least one selected from a target product, a reaction intermediate, and a reaction byproduct, and the catalyst is produced from at least one component selected from the target product, reaction intermediate, and reaction byproduct each formed as a result of the reaction and is used in the oxidation reaction so as to make up for a loss of the catalyst due to denaturation in the reaction. The method can easily and inexpensively make up for a loss of the catalyst denaturated in the course of reaction. | 2008-10-30 |
20080269508 | Method for Manufacture of 4-Hydroxy Pyran-2-One Derivatives - A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), | 2008-10-30 |
20080269509 | Oxidation of Alcohol with Use of Hydrogen Peroxide and Tungsten Catalyst - Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst. | 2008-10-30 |
20080269510 | New alpha-glucosidase inhibitors and antibacterial compounds from Myrtus communis L. - Three new acylphloroglucinols, myrtucommulone-D (Compound 1), myrtucommulone-E (Compound 2), myrtucommulone-C (Compound 3), and a known acyphloroglucinol myrtucommulone B (Compound 4) were isolated from a methanolic extract of | 2008-10-30 |
20080269511 | Total Synthesis of Myriaporones - Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′ | 2008-10-30 |
20080269512 | Large Scale Method for the deoxofluorination of ketones - A method for the deoxofluorination of a ketone for the production of a geminal difluoride compound in an industrial scale comprising the following steps:
| 2008-10-30 |
20080269513 | Integrated Process for the Preparation of Fatty Acid Methyl Ester (Biodiesel) - The disclosure provides methods and systems for the production of biodiesel from biological feedstocks such as vegetable oils or animal fats. In particular, the disclosure is directed to the product of biodiesel from seeds such as non-edible oil seeds. Methods for maximizing oil recovery from the feedstocks are provided, as well as methods to convert free fatty acids in the feedstocks into glycerides amenable to transesterification. Thus the methods and systems provide for efficient biodiesel production. | 2008-10-30 |
20080269514 | Iron or Cobalt-Catalyzed Carbon-Carbon Coupling Reaction of Aryls, Alkenes and Alkines With Copper Reagents - The present invention relates to a process for the formation of carbon-carbon bonds starting from a copper compound of an aryl, heteroaryl, alkene or alkine and an aryl, heteroaryl, alkene or alkine compound having a suitable leaving group. The copper compounds can be prepared inter alia by means of transmetalliziation from a Grignard or lithium compound. Cross-coupling of these compounds with e.g. a halogen-substituted aryl compound is carried out by means of an iron or cobalt catalyst using suitable solvents and suitable additives. | 2008-10-30 |
20080269515 | Process for the oxidation of a gas mixture containing hydrogen chloride - Chlorine is prepared by catalytic oxidation of a hydrogen chloride stream having a content of sulfur in elemental or bonded form of less than 100 ppm, preferably less than 50 ppm, more preferably less than 5 ppm, most preferably less than 1 ppm, based on the weight of the hydrogen chloride stream. | 2008-10-30 |
20080269516 | Process for Preparing the Intermediate Compounds for Pparalpha Ligands - The present invention provides a process for preparing the compounds of formula (II) according to a single reaction, which is an important intermediate compound for synthesizing GW7647 (III) and GW9578 (IV) activating Peroxisome Proliferator Activated Receptor (HPPAR α). | 2008-10-30 |
20080269517 | PROCESS FOR THE PREPARATION OF ACID HALIDES - A process for the preparation of acid halides of formula I | 2008-10-30 |
20080269518 | Method and apparatus for carbonylation with reduced catalyst loss - An apparatus and method for carbonylating a reactant, including sequestering Group VIII catalyst metal from a process stream which generally has a ppb concentration of the catalyst metal. The process stream is treated with a polymer having nitrogen-containing heterocyclic repeat units to sequester the catalyst from the stream, thus allowing valuable catalyst to be recovered and returned to the reaction mixture. An apparatus provides a resin bed downstream of the light ends column in a carbonylation process. Preferably, spent resin is regenerated with a regenerant composition compatible with the carbonylation reaction mixture so that catalyst metal can be directly recycled and the resin re-used. | 2008-10-30 |
20080269519 | Process and Catalyst for the Manufacture of Acetic Acid - A process and catalyst for the production of acetic acid by the carbonylation of methanol and/or a reactive derivative thereof wherein the catalyst system comprises a rhodium carbonylation catalyst, methyl iodide, a non-hydrohalogenoic acid promoter and optionally a co-promoter capable of generating ionic iodide. | 2008-10-30 |
20080269520 | Process for the Carbonylation of a Conjugated Diene to a Dicarboxylic Acid - A process for the carbonylation of a conjugated diene to a dicarboxylic acid, comprising the steps of (a) contacting a conjugated diene with carbon monoxide and water in the presence of a catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand, to obtain a mixture comprising an ethylenically unsaturated acid and reversible diene adducts; (b) separating the obtained reaction mixture into a gaseous stream comprising unreacted conjugated diene and carbon monoxide, a first normally liquid stream comprising at least part of the ethylenically unsaturated acid and the reversible diene adducts, and a second normally liquid stream comprising the catalyst system in admixture with the ethylenically unsaturated acid; (c) recycling the second liquid stream obtained in step (b) to step (a); (d) separating the first liquid product stream obtained in step (b) into a stream comprising the ethylenically unsaturated acid and a stream comprising the reversible diene adducts; and (e) contacting the stream comprising the ethylenically unsaturated acid obtained in step (d) with carbon monoxide and water in the presence of a second catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand. | 2008-10-30 |
20080269521 | PROCESS FOR STARTING-UP A HETEROGENEOUSLY CATALYZED PARTIAL GAS PHASE OXIDATION OF ACROLEIN TO ACRYLIC ACID OR OF METHACROLEIN TO METHACRYLIC ACID - A process for starting-up a heterogeneously catalyzed partial gas phase oxidation of acrolein to acrylic acid or of methacrolein to methacrylic acid over a fixed catalyst bed disposed in a tube bundle reactor cooled by a heat exchange medium, wherein the temperature of the heat exchange medium is ≧290° C. and the temperature of that reactor plate surface which faces the reaction gas entry mixture and the temperature of the reaction gas entry mixture itself are ≦285° C. | 2008-10-30 |
20080269522 | PROCESS FOR OPERATING AN EXOTHERMIC HETEROGENEOUSLY CATALYZED PARTIAL GAS PHASE OXIDATION OF AN ORGANIC STARTING COMPOUND TO AN ORGANIC TARGET COMPOUND - A process for operating an exothermic heterogeneously catalyzed partial gas phase oxidation of an organic starting compound in a tube bundle reactor cooled with a fluid heat carrier, in which an increase in the loading of the fixed catalyst bed disposed in the reaction tubes with the organic starting compound is preceded by an increase in the inlet temperature of the fluid heat carrier into the space surrounding the reaction tubes. | 2008-10-30 |
20080269523 | Preparation of Aminoaryl and Aminoheteroaryl Boronic Acids and Derivatives Thereof - The invention relates to a method for preparation of aminoaryl- or aminoheteroarylboronic acids and esters and salts thereof in which an optionally substituted aminoaryl or aminoheteroaryl compound is protected at its nitrogen site via condensation with a carbonyl compound, subsequently metalated and converted with a suitable boron compound. Depending on the subsequent work-up and removal of the protective group, the corresponding boronic acid, the anhydride or the boronic acid ester thereof is obtained | 2008-10-30 |
20080269524 | Separation of Stereoisomeric N,N-Dialkylamino-2Alkyl-3-Hydroxy-3-Phenylalkanes - The invention concerns a method for the isolation of a stereoisomer from a mixture comprising the two stereoisomers of the general formulae (I-A) and (I-A′) and/or the two stereoisomers of the general formulae (I-B) and (I-B′) | 2008-10-30 |
20080269525 | SYNTHESIS OF STABLE CYCLOPROPENYLIDENES - The invention provides for stable and isolable cyclopropenylidenes of Formula I and stable and isolable cyclopropenylidene-metal complexes of Formula II, and methods of making thereof. | 2008-10-30 |
20080269526 | METHODS OF MAKING AN ANTISTATIC AGENT - Disclosed are methods for making the phosphonium sulfonate salt of generic formula (1): | 2008-10-30 |
20080269527 | ISOTOPICALLY TAGGED SYNONS FROM 2 CARBON PRECURSORS - The use of vinyl sulfides, sulfoxides and sulfones in synthetic chemistry for the production of a wide variety of materials is well known. For example, phenyl vinyl sulfides, sulfoxides and sulfones have been used for the synthesis of important heterocycles, in combinatorial chemistry and as Diels-Alder adducts. Although these compounds have been used extensively for a variety of applications, the isotopically labeled versions have not been reported. A simple route for the isotopically labeled production of these important building blocks has been developed. | 2008-10-30 |
20080269528 | Method for the Production of Optically Active Carbonyl - The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating α,β-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are soluble in the reaction mixture and have at least one carbon monoxide ligand. The present invention especially relates to a process for preparing optically active aldehydes or ketones, in particular citronellal, by asymmetrically hydrogenating the corresponding optically active α,β-unsaturated aldehydes or ketones. | 2008-10-30 |
20080269529 | Chiral Compound Suitable as a Catalyst for Asymmetric Transfer Hydrogenation - The invention relates to an enantiomerically enriched chiral compound comprising a transition metal M, which comprises four, five or six coordinating groups of which at least one pair is linked together to form a bidentate ligand, in which M is directly bound via one single σ-bond to a carbon atom of an optionally substituted and/or optionally fused (hetero)aromatic ring of said bidentate ligand and in which M is directly bound to a nitrogen atom of a primary or secondary amino group of said bidentate ligand, thereby forming a metallacycle between said bidentate ligand and the metal M, said metal M being selected from the metals of groups 8 and 9 of the Periodic Table of the Elements, in particular iron, ruthenium, osmium, cobalt, rhodium, or iridium. The chiral compound can be used as a catalyst, preferably in an asymmetric transfer hydrogenation process. The invention further relates to a process for an asymmetric transfer hydrogenation of a prochiral compound in the presence of a hydrogen donor and the chiral compound of the invention comprising a transition metal chosen from the metals of groups 8, 9 and 10 of the Periodic Table, in particular iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium or platinum as the catalyst. | 2008-10-30 |
20080269530 | Method for Producing Alpha-Bisabolol from Farnesol - The present invention relates to a process for preparing α-bisabolol, comprising the reaction of farnesol in the presence of a ketone, of a sulfonic acid and of a further strong acid. | 2008-10-30 |
20080269531 | Catalytic Process and Apparatus for Selective Hydration of Alkylene Oxide - The present invention relates to an apparatus for the catalytic production of alkylene glycol from alkylene oxide, comprising: a reactor having at least one heat exchange element incorporated therein, wherein a catalyst for the hydration of alkylene oxide to alkylene glycol is coated on the outer surface of the heat exchange element. The present invention also relates to a process utilizing such an apparatus. | 2008-10-30 |
20080269532 | HIGH SELECTIVITY PROCESS TO MAKE DIHYDROFLUOROALKENES - Disclosed is a method for the synthesis of fluorinated alkenes comprising contacting a fluorinated alkyne of the formula R | 2008-10-30 |
20080269533 | Method of selectively hydrogenating conjugated diene by using supported ionic liquid nano-pd catalyst - A method of selectively hydrogenating a conjugated diene by using a supported ionic liquid nano-palladium catalyst. The supported ionic liquid nano-palladium catalyst, hydrogen and a reactant having the conjugated diene react at a temperature ranging from 40 to 120° C. and a pressure ranging from 100 to 400 psig. A ratio of the catalyst to the reactant ranges from 1/20 to 1/250 (g/ml). | 2008-10-30 |
20080269534 | Hydrocarbon synthesis - A method of synthesizing hydrocarbons from smaller hydrocarbons includes the steps of hydrocarbon halogenation, simultaneous oligomerization and hydrogen halide neutralization, and product recovery, with a metal-oxygen cataloreactant used to facilitate carbon-carbon coupling. Treatment with air or oxygen liberates halogen and regenerates the cataloreactant. | 2008-10-30 |
20080269535 | PROCESS FOR PRODUCING HIGH PURITY META-XYLENE, COMPRISING SIMULATED MOVING BED ADSORPTION AND CRYSTALLIZATION - The invention concerns a process for producing high purity meta-xylene, comprising a step for separation by simulated moving bed adsorption starting from an aromatic C8 feed delivering a fraction which is rich in meta-xylene and a fraction which is depleted in meta-xylene, and a step for crystallization of the meta-xylene rich fraction. The purity of the meta-xylene produced is at least 99.5%. | 2008-10-30 |
20080269536 | Method for Producing Propene From Propane - The invention relates to a process for preparing propene from propane, comprising the steps: | 2008-10-30 |
20080269537 | METAL BINDING PROTEINS AND ASSOCIATED METHODS - Metal binding proteins, associated compositions and methods for their production and use are disclosed. The metal binding proteins included have amino acid sequences analogous to at least one metal binding protein, and conservative amino acid substitutions thereof from a brine shrimp ( | 2008-10-30 |
20080269538 | Waste Treatment Process - Process for treating waste containing heavy metals, the process including a phosphating operation, a step of foaming the waste and a step of drying the foam, in which the waste undergoing the treatment results from the addition, to a base waste lightly contaminated with heavy metals, of a secondary waste whose content of heavy metals is at least twice that of the base waste. | 2008-10-30 |
20080269539 | Brachytherapy Device Having an Alignment and Seal Adaptor - A brachytherapy device for treating tissue within a cavity of a body. The device may include a first set of tubes configured to be inserted into the cavity through an opening at the surface of the body. Each of the tubes may have an external end and an interior channel beginning at the external end that is configured to receive radioactive material. The external ends of the tubes may be bundled together. The tubes may be of a length that causes the external ends to be near the opening in the surface of the body while the tubes are in the cavity. A seal may be configured to prevent fluid that originates from the cavity from entering into the external ends of the tubes while they are near the opening in the surface of the body. The seal may include a gasket that is pressed against the external ends of the tubes. The gasket may have openings that align with channels within the external ends of the tubes. | 2008-10-30 |
20080269540 | SEED CARTRIDGE ADAPTOR AND METHODS FOR USE THEREWITH - Provided herein are adaptors that enable a seed cartridge that is configured to be used with a first type of needle having a locking hub to instead be used with a second type of needle having a cylindrical hub. Such a seed cartridge has a hub at its distal end that is configured to attach to the locking hub of the first type of needle. The adaptor includes a proximal portion configured to removably attach (and in specific embodiments lock) to the hub at the distal end of the seed cartridge. The adaptor also includes a distal portion configured to removably attach to the cylindrical hub of the second type of needle. A central portion of the adaptor connects the proximal and distal portions of the adaptor. A bore extends through the adaptor and allows seeds and optional spacers to be transferred from the seed cartridge into a hollow cannula of the second type of needle. Also provided herein are methods for using such adaptors. | 2008-10-30 |
20080269541 | Mechanized, adjustable magnetic device for therapy - A magnetic therapy apparatus has adjustable space between the poles to accommodate various thicknesses of the body parts that are to be treated. This eliminates the inconvenience of exchanging various pole sizes for the various targets to be treated. The entire treatment zone can be rotated to accommodate both vertical and horizontal targets. The heavy apparatus includes a transportation dolly and a hydraulically actuated system for tilting the axis of the poles to various positions. An alternative system of varying the distances between the poles uses two rotating arms cantilevered with the poles at the extremities of the arms. | 2008-10-30 |
20080269542 | Systems and Methods for Therapeutically Treating Neuro-Psychiatric Disorders and Other Illnesses - Systems and methods for treating neuro-psychiatric disorders, such as depression or schizophrenia, and/or other illnesses are disclosed. A patient is diagnosed with a particular neuro-psychiatric disorder or other illness. An electric nerve stimulation (ENS) technique, such as vagus nerve stimulation (VNS), is administered to the patient in conjunction with a magnetic nerve stimulation (MNS) technique. The magnetic nerve stimulation (MNS) technique includes applying a magnetic field to a pre-selected synaptic region of a brain of the patient based on the diagnosis. A physiological response of the brain, such as electroencephalogram (EEG) activity, is monitored. One or more parameters of the magnetic field may be selectively adapted in response to the monitored physiological response. The administration of the ENS technique and the MNS technique may be performed simultaneously, in serial order, or in alternating order depending on the diagnosis. | 2008-10-30 |
20080269543 | Functional Device with a Detachable Component - A device for enhancing blood circulation that includes a main element, a detachable element with an identification mark, and attachment means for grasping the detachable element by the main element. The main element functions by intermittently tightening and relaxing its grasp of the detachable element when activated. Additionally the main element authenticates the identification mark of the detachable element; and the main element is enabled to function if the authentication of the identification mark is positive. | 2008-10-30 |