45th week of 2015 patent applcation highlights part 21 |
Patent application number | Title | Published |
20150315086 | COLORED TRANSLUCENT ZIRCONIA SINTERED BODY AND ITS USE - A pink-colored zirconia sintered body has a high sintered body density and strength, and a colored translucency, which has a color tone similar to teeth and excellent translucency and has high aesthetic properties. A colored translucent zirconia sintered body includes from 2 to 4 mol % of yttria, from 0.02 to 0.8 mol % of Er | 2015-11-05 |
20150315087 | DIAMOND POLYCRYSTALLINE BODY AND METHOD FOR MANUFACTURING THE SAME, AND TOOL - Provided are a diamond polycrystalline body having a longer life than conventional diamond polycrystalline bodies when it is slid, a method for manufacturing the same, and a tool. In a diamond polycrystalline body, at least one element whose sulfide or chloride has a melting point of less than or equal to 1000° C. is added thereto, and crystal grains have an average grain size of less than or equal to 500 nm. Thereby, wear of diamond can be suppressed, and the diamond polycrystalline body can have a longer life when it is slid. | 2015-11-05 |
20150315088 | SIALON BONDED SILICON CARBIDE MATERIAL - A silicon carbide based material exhibiting high strength, good thermal shock resistance, high resistance to abrasion and being chemically stable to harsh environmental conditions is described. The carbide Ball Hill ceramic comprises a β-SiAlON bonding phase in which sintering is facilitated by at least one rare earth oxide sintering agents incorporated within the Vibrating Sieve batch admixture as starting materials. The residual rare earth sintering aid being chosen so as to impart good mechanical and refractory properties. | 2015-11-05 |
20150315089 | METHODS AND SYSTEMS FOR THE FORMATION AND USE OF REDUCED WEIGHT BUILDING BLOCKS FORMS - In some embodiments, a method may include preparing building forms including at least some cementitious materials. The method for preparing forms may include mixing substantially dry cementitious material particles with closed cell foam particles to form a substantially dry composition. In some embodiment, at least some of the cementitious material particles may adhere to at least some surface deformations on the surface of the closed cell foam particles. In some embodiments, the method may include mixing a second portion of water with the substantially dry composition for a second period of time to form a partially wet composition. In some embodiments, a method may include forming a building form including at least some cementitious materials from the partially wet composition. In some embodiments, the closed cell foam particles may include expanded polystyrene. In some embodiments, a ratio of the water to cementitious material particles may range from 0.20 to 0.40. | 2015-11-05 |
20150315090 | LASER GLAZING USING HOLLOW OBJECTS FOR SHRINKAGE COMPLIANCE - Hollow objects ( | 2015-11-05 |
20150315091 | MICROENCAPSULATED NITRIFICATION INHIBITOR COMPOSITION - The present invention relates to an improved nitrification inhibitor composition and its use in agricultural applications. | 2015-11-05 |
20150315092 | INCREASED LONGEVITY OF THE NITROGEN CONTENT OF SOIL THROUGH IMPROVED LIQUID DELIVERY FORMULATIONS OF NITRIFICATION INHIBITORS DESIGNED FOR UREA AND MANURE BASED FERTILIZERS - Increasing longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors. The liquid formulation can also be comprised of nitrification inhibitors and urease inhibitors that are co-dissolved or blended solutions of each These novel formulations are designed to apply to fertilizers, especially urea and manure based fertilizers These delivery formulations provide an environmentally sound and inherently safe solvating system that improves the storage stability of the urease inhibitors by utilizing liquid organic non-water containing solvents, maintain the nitrification inhibitors in solution to storage temperatures of at least 10° C. and provides improved application to fertilizer of nitrification inhibitors. These delivery formulations enable safe storage, transport and subsequent application or blending with urea based or manure based fertilizers that can be applied to soil in either a liquid or granular form to provide improved nitrogen retention in the soil for uptake for plant life. | 2015-11-05 |
20150315093 | METHODS TO DESENSITIZE HYDRAZINIUM NITROFORMATE (HNF) - Disclosed herein are energetic compositions and methods of making thereof. A composition includes hydrazinium nitroformate (HNF) particles dispersed in a polymeric binder and a bonding agent bonded to a surface of at least a portion the HNF particles. The bonding agent disclosed is a Lewis acid. | 2015-11-05 |
20150315094 | SOLIDS CONTENT CONTROL IN IONIC LIQUID ALKYLATION PROCESS - The present invention relates to a continuous or non-continuous ionic liquid alkylation process comprising a step for solids removal, the process further comprising the steps (a) measuring the solids content in the ionic liquid alkylation process stream by on line (in situ) or off line sampling; (b) in response to the solids measurement signal, regulating the flow of the ionic liquid side stream to be sent to the solids removal device; (c) regulating the flow of the fresh ionic liquid inlet stream, for controlling the solids content in the ionic liquid alkylation process to a pre-defined level. The process of the invention provides a means to more efficiently run an ionic liquid alkylation process. | 2015-11-05 |
20150315095 | HYDROCARBON CONVERSION PROCESS INCLUDING CATALYST REGENERATION - A hydrocarbon conversion process is described. The process includes contacting a hydrocarbon feed with an acidic catalyst under hydrocarbon conversion conditions in a hydrocarbon conversion zone. The hydrocarbon feed reacts to form a mixture comprising reaction products, the acidic catalyst, and deactivated acidic catalyst containing conjunct polymer. The mixture is separated into at least two streams, a first stream comprising the reaction products and a second stream comprising the deactivated acidic catalyst. The reaction products are recovered. The deactivated acidic catalyst is contacted with at least one silane or borane compound in a regeneration zone under regeneration conditions, the conjunct polymer reacting with the at least one silane or borane compound resulting in a catalyst phase and an organic phase containing the conjunct polymer and at least one silyl or boryl compound. | 2015-11-05 |
20150315096 | Process for Producing Cumene With Alkylation Effluent Recycle - In a process for producing cumene, a C | 2015-11-05 |
20150315097 | Renewable High Density Turbine And Diesel Fuels From Sesquiterpenes - A fuel and method for conversion of sesquiterpenes to high density fuels. The sesquiterpenes can be either extracted from plants or specifically produced by bioengineered organisms from waste biomass. This approach allows for the synthesis of high performance renewable fuels. | 2015-11-05 |
20150315098 | PROCESS FOR INCREASING THE YIELD OF AN ISOMERIZATION ZONE FRACTIONATION - A process for increasing a yield of an isomerization zone by removing at least a portion of the C | 2015-11-05 |
20150315099 | PROCESS FOR CONTROLLING THE YIELD OF AN ISOMERIZATION ZONE - A process for controlling a yield of an isomerization zone. Prior to entering the isomerization zone, C | 2015-11-05 |
20150315100 | PROCESS FOR INCREASING THE YIELD OF AN ISOMERIZATION ZONE - A process for increasing a yield of an isomerization zone by removing at least a portion of the C | 2015-11-05 |
20150315101 | PROCESS FOR INCREASING THE YIELD OF AN ISOMERIZATION ZONE - A process for increasing a yield of an isomerization zone by removing at least a portion of the C | 2015-11-05 |
20150315102 | PROCESS FOR PRODUCING A FEED STREAM FOR A STEAM CRACKER - A process for producing a feed for a stream cracker. At least a portion of the C | 2015-11-05 |
20150315103 | PROCESS FOR PREPARING ALKYLATE COMPRISING AN IMPROVED SOLIDS REMOVAL STEP - The present invention relates to a process for preparing alkylate comprising the subsequent steps (a), (b) and (c):
| 2015-11-05 |
20150315104 | Hydrocarbon Gas Processing - A process and an apparatus are disclosed for a compact processing assembly to improve the recovery of C | 2015-11-05 |
20150315105 | Hydrocarbon Processing - A process and an apparatus are disclosed for a compact processing assembly to fractionate lighter components from mixed hydrocarbon streams. The hydrocarbon stream is supplied to the processing assembly between an absorbing means and a mass transfer means. A distillation vapor stream is collected from the upper region of the absorbing means and cooled in a first heat and mass transfer means inside the processing assembly to partially condense it, forming a volatile stream and a condensed stream. The condensed stream is supplied to the absorbing means as its top feed. A distillation liquid stream is collected from the lower region of the mass transfer means and heated in a second heat and mass transfer means inside the processing assembly to strip out its volatile components, forming a relatively less volatile stream and a vaporized stream. The vaporized stream is supplied to the mass transfer means as its bottom feed. | 2015-11-05 |
20150315106 | Hydrocarbon Gas Processing - A process and an apparatus are disclosed for a compact processing assembly to remove C | 2015-11-05 |
20150315107 | Process for Selective Removal of Acetylenes from Gaseous Streams - The present discloses a process and catalyst therefor to selectively remove acetylenes from gaseous streams in the vapor phase. The process is particularly suitable for high yield recovery of olefinic hydrocarbons from gaseous streams in refinery processes. | 2015-11-05 |
20150315108 | METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUNDS - Disclosed are processes for the production of fluorinated olefins, preferably adapted to commercialization of CF | 2015-11-05 |
20150315109 | PROCESS AND APPARATUS FOR THE PRODUCTION OF HIGHER ALCOHOLS - In a process for the production of higher alcohols, i.e. C | 2015-11-05 |
20150315110 | ALUMINUM CATALYST - An aluminum catalyst is obtained by reacting at least one compound of a specific alkylaluminum compound and a specific hydridoaluminum compound with a specific hydroxy compound. The specific hydroxyl compound is a specific 2-cycloalkyl-6-arylphenol or a specific di(2-cycloalkyl-6-arylphenol). A method for producing isopulegol or optically active isopulegol includes selectively cyclizing citronellal using the aluminum catalyst. | 2015-11-05 |
20150315111 | Processes for Producing Phenol - Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the treated cleavage reaction mixture contains no greater than 50 wppm of the acid catalyst or no greater than 50 wppm of the basic material. | 2015-11-05 |
20150315112 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY - The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA. | 2015-11-05 |
20150315113 | POLYTHIOLS AS CIS/TRANS ISOMERIZATION CATALYSTS FOR UNSATURATED COMPOUNDS - The present invention relates to a process of a cis/trans isomerization of an unsaturated compound A being selected from the group consisting of unsaturated ketones, unsaturated ketals, unsaturated aldehydes, unsaturated acetals, unsaturated carboxylic acids, esters of an unsaturated carboxylic acid and amides of an unsaturated carboxylic acid using polythiol as cis/trans isomerization catalyst. It has been observed that the isomerization is very efficient and fast. | 2015-11-05 |
20150315114 | Methods of Synthesizing a Prostacyclin Analog - The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R | 2015-11-05 |
20150315115 | METHOD FOR PRODUCING ACRYLIC ACID - Method for producing acrylic acid by dehydration of a C | 2015-11-05 |
20150315116 | PURE PLANT MOTHER LIQUOR SOLVENT EXTRACTION SYSTEM AND METHOD - The invention relates to a process for producing terephthalic acid and for purifying the mother liquor resulting from said process. Useful compounds can be extracted from the mother liquor and the purified mother liquor can be returned for use in the process. Advantageously, certain parameters of the mother liquor purification method are selected such that the purification provides an economic benefit as compared with other purification methods. | 2015-11-05 |
20150315117 | Polyester Polyols and Methods of Making and Using the Same - Polyester polyols are generally disclosed, including methods of making and using them. In some embodiments, the polyester polyols are incorporated into a block copolymer, such as a polyurethane block copolymer. In some embodiments, at least a portion of the polyurethane block copolymer is derived from a renewable source. | 2015-11-05 |
20150315118 | METHOD OF PRODUCING INGENOL-3-ANGELATE - The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). | 2015-11-05 |
20150315119 | PROCESS FOR SEPARATING VINYL ESTERS FROM A GAS STREAM COMPRISING ETHYLENE AND VINYL ESTERS - Process for separating esters of vinyl alcohol from a gas stream comprising from 70 to 99.5% by weight of ethylene and from 0.5 to 30% by weight of esters of vinyl alcohol being at a pressure in the range of from 0.5 MPa to 10 MPa and a temperature in the range of from 5° C. to 50° C. comprising the steps of
| 2015-11-05 |
20150315120 | PROCESS FOR PRODUCING ALKYL ACRYLATE - The invention relates to the production of alkyl acrylate according to a continuous transesterification process. In one embodiment the process of the invention uses a simple column to purify a reaction mixture of acryl acrylate in one step yielding alkyl acrylate with a purity of greater than 99.8%. | 2015-11-05 |
20150315121 | Method for Preparing Carbonic Ester Using Organometallic Compound - A method for preparing a carbonic ester includes reacting carbon dioxide and a C | 2015-11-05 |
20150315122 | Method of Preparing Aromatic Carbonate From Dialkyl Carbonate - A method of preparing an aromatic carbonate includes reacting a dialkyl carbonate with an aromatic alcohol in the presence of a catalyst represented by Formula 1. With the method, aromatic carbonate can be prepared from a dialkyl carbonate in high yield using a catalyst capable of increasing initial reactivity of the dialkyl carbonate. | 2015-11-05 |
20150315123 | POLYGLYCEROL PARTIAL ESTERS, PREPARATION AND USE THEREOF - Polyglycerol partial esters of a specific composition which are capable of solubilizing very hydrophobic, oil-soluble substances in aqueous solution are provided. The preparation and use of these polyglycol ether-free solubilizers in cosmetic formulations are also disclosed. | 2015-11-05 |
20150315124 | INGENOL-DERIVED COMPOUNDS THAT CAN BE USED FOR TREATING CANCER - The present invention relates to new ingenol derivative compounds for treating cancer. In other aspects, the invention relates to a pharmaceutical composition, medicament, method for treating cancer and dosage form. | 2015-11-05 |
20150315125 | SYNTHESIS SYSTEM, RUBBER CHEMICAL SUBSTANCE FOR TIRES, SYNTHETIC RUBBER FOR TIRES, AND PNEUMATIC TIRE - The present invention provides a synthesis system that can synthesize aniline and/or styrene efficiently, a synthesis system that can synthesize butadiene (1,3-butadiene) efficiently, a rubber chemical for a tire which is synthesized from the aniline obtained by the synthesis system, a synthetic rubber for a tire which is synthesized from the styrene and/or butadiene obtained by the synthesis systems, and a pneumatic tire produced using the rubber chemical for a tire and/or the synthetic rubber for a tire. The present invention relates to a synthesis system for synthesizing aniline and/or styrene from an alcohol having two or more carbon atoms via an aromatic compound. | 2015-11-05 |
20150315126 | CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A - The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R | 2015-11-05 |
20150315127 | THERAPEUTIC COMPOUNDS - The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs. | 2015-11-05 |
20150315128 | BICYCLIC COMPOUNDS - Disclosed are compounds of Formula (I) | 2015-11-05 |
20150315129 | PROCESSES FOR FORMING AMIDE BONDS AND COMPOSITIONS RELATED THERETO - The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed. In another embodiment, the disclosure relates to mixing a thiolacid, a silylating agent, and an amine under conditions such that an amide is formed. | 2015-11-05 |
20150315130 | New positive allosteric modulators of nicotinic acetylcholine receptor - The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor. | 2015-11-05 |
20150315131 | COMBINATION USES OF DICHLOROACETATE AND OXAMATE, AND THEIR PRODRUGS, FOR CANCER TREATMENT - The invention novel compounds, pharmaceutical compositions and methods useful for preventing or treating cancer in animals and humans. Also, the invention provides novel prodrugs useful for reducing tumor size, and inhibiting the growth of cancers, inhibiting tumor cell growth and tumor cell proliferation, and promoting apoptosis of tumor cells. When used in combination with chemoradiation thereapy, the novel compounds, compositions and prodrugs provided herein can improve the effectiveness of chemoradiation therapy. The novel compounds, compositions and prodrugs of the invention inhibit PDK and LDH in unique and effective ways. | 2015-11-05 |
20150315132 | AMINOCYCLOBUTANE DERIVATIVES, METHOD FOR PREPARING SAME AND THE USE THEREOF AS DRUGS - The present inventions concerns derivatives of aminocyclobutane, particularly as NMDA receptor antagonists, their application in human therapy and their method of preparation. | 2015-11-05 |
20150315133 | Method For Preparing 3-Aminomethyl-3,5,5-Trimethyl Cyclohexylamine - The present invention provides a method for preparing 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method comprises: a) reacting 3-cyano-3,5,5-trimethyl cyclohexanone with excess primary amine as well as removing the water generated from the reaction, so that IPN is substantially converted into imine compounds; b) in the presence of an ammonolysis catalyst, mixing the product of step a) with liquid ammonia, making the imine compound perform ammonolysis reaction to generate 3-cyano-3,5,5-trimethyl cyclohexylimine and the primary amine; and c) in the presence of hydrogen and a hydrogenation catalyst, hydrogenating 3-cyano-3,5,5-trimethyl cyclohexylimine obtained in step b) to obtain 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. The method of the present invention avoids the generation of 3,5,5-trimethyl cyclohexanol and 3-aminomethyl-3,5,5-trimethyl cyclohexanol as the major by-products in the prior art, thereby improving the yield of 3-aminomethyl-3,5,5-trimethyl cyclohexylamine. | 2015-11-05 |
20150315134 | SYNTHESIS OF METHYL CARBAMATE AND DIMETHYL CARBONATE (DMC) IN PRESENCE OF STRIPPING WITH INERT GAS OR SUPERHEATED VAPOURS AND A REACTOR FOR THE SAME - The invention relates to synthesis of methyl carbamate (MC) and dimethyl carabonate (DMC) in presence of stripping inert gas or superheated methanol vapors using packed column reactor and bubble column reactor. | 2015-11-05 |
20150315135 | Sulphated Chelating Agent - This invention refers to a series of substances according to formula (I): and its synthesis process. The subtances according to formula I above, known as sulphated chelating agents have the ability to enlarge/loosen simple cell membranes or common organic membranes. Furthermore, these subtances have the potential as biocides raw material, with very low toxicity to mammals. These features make the substances of this invention become very useful on many applications. | 2015-11-05 |
20150315136 | METHOD FOR PRODUCING FLUORINATED ORGANIC COMPOUND AND FLUORINATING REAGENT - Object: An object of the present invention is to provide a method for producing, with a high yield, a fluorinated organic compound, the fluorinated organic compound having not been produced with a sufficient yield by a conventional method for producing a fluorinated organic compound using a fluorinating agent containing IF | 2015-11-05 |
20150315137 | System and Method for Fluoroalkylated Fluorophthalocyanines With Aggregating Properties and Catalytic Driven Pathway for Oxidizing Thiols - Organo-metallic materials with reduced steric hindrance and the ability to aggregate are disclosed. The metal remains capable of binding additional molecules. As an example, Zn complexes that prove aggregation are provided. Such aggregation may help improve or trigger new surface properties of the materials, alone or in combination with others. In a further implementation of the present disclosure, a robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is provided. Coordinated O | 2015-11-05 |
20150315138 | PROCESSES FOR THE CONVERGENT SYNTHESIS OF CALICHEAMICIN DERIVATIVES - This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates. | 2015-11-05 |
20150315139 | Industrial Methods for Producing Arylsulfur Pentafluorides - Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the absence or presence of one or more additives selected from a group of fluoride salts, non-fluoride salts, and unsaturated organic compounds to form arylsulfur pentafluorides. | 2015-11-05 |
20150315140 | PROCESS FOR PREPARING AMINES - The present invention refers to a process for preparing amines comprising reacting a compound of the formula R | 2015-11-05 |
20150315141 | Thrombin Inhibitors - Compounds of the invention, which may be useful in inhibiting thrombin and associated thrombotic occlusions, have the following structure: | 2015-11-05 |
20150315142 | PROCESS TO OBTAIN IMIDAZOLINE MIXTURES FROM VEGETABLE OILS - A method to obtain imidazoline mixtures capable of providing considerable energy savings during the manufacture process due to a notable reduction of process temperature and lower requirements of chemical raw materials, and it allows for the direct use of vegetable oils, instead of fatty acids or their esters, producing imidazolines containing a (2-hydroxyethyl) group on position one of the ring and on position 2, a hydrocarbonated chain, from the fatty acids present in coconut oil, palm oil, jathrofa or castor. Likewise, the application of these mixtures as corrosion inhibitors has been established, in addition to quaternized imidazolines, which have applications as cationic surfactants, fabric softeners, hair conditioners and antistatic agents. It is an optimized method that compared to other known methods, uses substoichiometric proportions of aminoethylethanolamine and lower reaction temperatures, without using dehydrating agents or catalysts, or azeotropic distillation, which involves the use of highly flammable solvents. | 2015-11-05 |
20150315143 | N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles - Transition metal-free catalytic methods for access to 2-arylindole compounds. | 2015-11-05 |
20150315144 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS - The present invention provides compounds of Formula (I): | 2015-11-05 |
20150315145 | PROCESS FOR PRODUCING OPTICALLY ACTIVE BICYCLIC UREA COMPOUND - A problem to be solved by the present invention is to provide a process for producing an optically active bicyclic urea compound useful as an intermediate for β-lactamase inhibitor, in a simple and easy manner with high efficiency. | 2015-11-05 |
20150315146 | USE OF SUBSTITUTED 1-(ARYL ETHYNYL)-, 1-(HETEROARYL ETHYNYL)-, 1-(HETEROCYCLYL ETHYNYL)- AND 1-(CYCLOALKENYLETHYNYL)-BICYCLOALKANOLS AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS - The invention relates to the use of substituted 1-(arylethynyl)-, 1-(heteroarylethynyl)-, 1-(heterocyclylethynyl)- and 1-(cycloalkenylethynyl)bicycloalkanols or salts thereof | 2015-11-05 |
20150315147 | COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF - The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. | 2015-11-05 |
20150315148 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF - Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein. | 2015-11-05 |
20150315149 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF - Methods are disclosed for the preparation of netupitant and pharmaceutically acceptable salts thereof which are novel, easily reproducible, environmentally safe and cost effective. The methods may employ inexpensive starting materials and the preparation processes for intermediates are simple and highly reproducible. Novel intermediates for the preparation of netupitant and pharmaceutically acceptable salts thereof are also disclosed. Amorphous netupitant and methods of making same are disclosed. | 2015-11-05 |
20150315150 | KINASE INHIBITORS AND METHODS OF THEIR USE - New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one PIM kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase- or receptor tyrosine kinase-mediated disorder, such as cancer. | 2015-11-05 |
20150315151 | PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The invention provides a process for the preparation of a compound of Formula 1, | 2015-11-05 |
20150315152 | Pharmaceutical Compositions for the Treatment of CFTR-Mediated Disorders - The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), solids forms, and pharmaceutical compositions thereof for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. The present invention also relates to the use of Compound 1 in combination with 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 2), and Compound 1 in combination with (S)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 3), for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. The present invention also relates to solid forms and formulations of Compound 2 or Compound 3 in combination with Compound 1, and pharmaceutical compositions thereof, for the treatment of CFTR-mediated diseases, particularly cystic fibrosis, in patients possessing specific genetic mutations. | 2015-11-05 |
20150315153 | NOVEL SULFONIC ACID DERIVATIVE COMPOUND, PHOTOACID GENERATOR, CATIONIC POLYMERIZATION INITIATOR, RESIST COMPOSITION, AND CATIONICALLY POLYMERIZABLE COMPOSITION - Provided are: a compound which shows large absorption for light having a wavelength of 365 nm and has good acid generation rate; and a photoacid generator, cationic polymerization initiator, resist composition and cationically polymerizable composition that use the compound. The sulfonic acid derivative compound of the present invention is characterized by being represented by the following Formula (I): | 2015-11-05 |
20150315154 | HISTIDINYLATED CATIONIC AMPHIPHILES, PROCESS FOR PREPARATION THEROF AND THEIR LIPOSOMAL FORMULATION - Novel anti-cancer reagents capable of combating various types of tumors continue to be major research focus in many leading pharmaceutical companies round the globe. To this end, the present invention discloses processes for preparing a novel series of histidinylated cationic amphiphiles of formula I. The findings described herein also demonstrate that compounds of the present invention possess anti-proliferative activity such as anti” cancer activity and are useful in combating various types of cancer. The pharmaceutically active composition of cationic amphiphiles disclosed herein show enhanced cellular apoptosis through the Bax & Bcl-2 mediated signal transduction pathway. Cationic amphiphiles with histidine head-groups described in the present invention are likely to find future applications in the field of anti-cancer therapy. | 2015-11-05 |
20150315155 | FIVE-MEMBERED CYCLIC ANION USE THEREOF AS AN ELECTROLYTE - A pentacyclic anion salt is provided for use thereof in electrolyte compositions. The compound has an inorganic, organic or organometallic cation M of valency m (1≦m≦3) and m anions corresponding to the formula (I) in which R | 2015-11-05 |
20150315156 | CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE 3/4 HYDRATE, METHOD FOR PRODUCING THE SAME AND CRYSTAL OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE HYDRATE - Provided is a method for producing 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate, including:
| 2015-11-05 |
20150315157 | PROLYL HYDROXYLASE INHIBITORS - The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I) | 2015-11-05 |
20150315158 | ISOTOPICALLY ENRICHED ARYLSULFONAMIDE CCR3 ANTAGONISTS - Provided herein are isotopically enriched arylsulfonamides, for example, of Formula I, that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated disease, disorder, or condition. | 2015-11-05 |
20150315159 | AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS - Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject. | 2015-11-05 |
20150315160 | SUBSTITUTED ISOXAZOLE AMINE COMPOUNDS AS INHIBITORS OF SCD1 - The invention is concerned with a compound of formula (I) wherein R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament. | 2015-11-05 |
20150315161 | N-(OXAZOL-2-YL)-ARYL-CARBOXYLIC ACID AMIDES AND USE THEREOF AS HERBICIDES - N-(Isoxazol-3-yl)arylcarboxamides and their use as herbicides are described. | 2015-11-05 |
20150315162 | Process for producing fucoxanthinol extract and methods of use - A process for obtaining a purified fucoxanthinol extract from an Echinozoa tissue or organ is disclosed, as well as methods of using said extract. Compositions comprising the extract, and their uses, are also described. Uses of the purified extract include methods for making medicaments or treatments for conditions such as, but not limited to, obesity, cancer, oxidative stress, diabetes, neurodegenerative disorders, and high blood pressure. | 2015-11-05 |
20150315163 | DEVICE AND METHOD FOR CONTINUOUSLY PREPARING HIGH-PURITY AKD WITHOUT SOLVENT - Device and method for continuously preparing high-purity AKD without solvent includes a reactor making continuous mixing of raw materials. The process includes: the tertiary amine feeding into the reactor and the continuously feeding acyl chloride from three to ten line; under operating state, the motor rotates the internal cylinder in relation to external cylinder, forcing the fed materials to convey and stir in the conveying section of annular column passage, forcing the materials to shear and mix by movement of shearing and kneading blades. Arrangement of conveying and mixing sections along the axial direction of annular column passage, causes sufficient reaction of materials and controls the material temperature through internal and external heat exchange systems until the reaction products are discharged from outlet. The device and process disperse reaction heat and sufficient material mixture and complete reaction to control the reaction temperature, viscosity and decrease the generation of side reaction. | 2015-11-05 |
20150315164 | PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL - The present invention provides a process for preparing amorphous Cabazitaxel from the solvate form of Cabazitaxel. | 2015-11-05 |
20150315165 | PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE - A novel process for the preparation of a fluorolactone derivative of the formula | 2015-11-05 |
20150315166 | Esterification of 2,5-Furan-Dicarboxylic Acid - A method of making a furan dicarboxylate by means of reacting 2,5-furan dicarboxylic acid (FDCA) with an alcohol or mixture of alcohols in a CO | 2015-11-05 |
20150315167 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Abexinostat tosylate of formula (II): | 2015-11-05 |
20150315168 | Catalytic Enantioselective Synthesis of 2-Aryl Chromenes and Related Phosphoramidite Ligands and Catalyst Compounds - Methods to access 2-aryl chromene compounds via an asymmetric catalytic process. | 2015-11-05 |
20150315169 | Heterocyclic Compound Preparing - Disclosed is a process for selectively producing (D+1)-member heterocyclic compounds from corresponding unactivated dienes or derivatives thereof in the presence of a transition metal or lanthanide catalyst or a precursor thereof, relative to D-member heterocyclic rings. | 2015-11-05 |
20150315170 | PRODUCTION METHOD OF CARBONYL COMPOUND - The present invention is to provide a method of producing a carbonyl compound at a higher yield. The method of producing a carbonyl compound according to the present invention produces a carbonyl compound represented by general formula (I) by subjecting a compound represented by general formula (II) to dealkoxycarbonylation in the presence of an organic carboxylic acid salt of a tertiary amine. | 2015-11-05 |
20150315171 | PROCESS FOR PREPARING ARYL - AND HETEROARYLACETIC ACID DERIVATIVES - The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents. | 2015-11-05 |
20150315172 | PYRIDONE COMPOUND - The invention provides a pyridone compound represented by the following formula (I) [wherein, R | 2015-11-05 |
20150315173 | NEW ANTI-INVASIVE COMPOUNDS - The present invention relates to a compound of formula (I): | 2015-11-05 |
20150315174 | Dendritic Molecular Intracellular Transporters and Methods of Making and Using Same - In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to compounds comprising the structure: | 2015-11-05 |
20150315175 | PRODUCTION METHOD FOR CYCLOPENTANONE DERIVATIVE, INTERMEDIATE COMPOUND, AND PRODUCTION METHOD FOR INTERMEDIATE COMPOUND - A method for producing a cyclopentanone derivative represented by general formula (III) below, wherein a cyclopentanone derivative represented by general formula (III) below can be produced with higher yield since the method comprises a step in which a compound represented by general formula (II) below is obtained by reacting a compound represented by general formula (I) below with an acid. | 2015-11-05 |
20150315176 | Process for the Preparation of 1-([1,3]dioxolan-4-ylmethyl)-1H-pyrazol-3-ylamine - The present invention relates to a novel process for the preparation of of the formula (I) (I) wherein R | 2015-11-05 |
20150315177 | SUBSTITUTED QUINONES OR ANALOGUES AS COLOURING AGENTS - The invention relates to protein-adhesive dyes, to the preparation thereof and to preparations comprising same, and to a method for colouring keratin-containing fibres, in particular for colouring human hair. | 2015-11-05 |
20150315178 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF - The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels. | 2015-11-05 |
20150315179 | COMPOUNDS AND METHODS OF TREATING NEUROLOGICAL DISORDERS - Embodiments of the present disclosure provide for compositions including a compound, pharmaceutical compositions including the compound, methods of treatment of a disease or related condition (e.g., neurological disease on condition), methods of treatment using compositions or pharmaceutical compositions, and the like. | 2015-11-05 |
20150315180 | INHIBITORS OF CYTOMEGALOVIRUS - Compounds of Formula (I) wherein n, R | 2015-11-05 |
20150315181 | CERTAIN AMINO-PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS FOR THEIR USE - Provided are compounds of Formula I: | 2015-11-05 |
20150315182 | SUBSTITUTED REVERSE PYRIMIDINE BMI-1 INHIBITORS - Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein. | 2015-11-05 |
20150315183 | NOVEL OCTAHYDROPYRIDOQUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES FOR SAID DERIAVATIVE AND COMPOSITION - [Problem] To provide a novel compound that exhibits an agonistic effect on dopamine D | 2015-11-05 |
20150315184 | 4-(8-METHOXY-1-((1-METHOXYPROPAN-2-YL)-2-(TETRAHYDRO-2H-PYRAN-4-YL)-1 H-IMIDAZO[4,5-C]QUINOLIN-7-YL)-3,5-DIMETHYLISOXAZOLE AND ITS USE AS BROMODOMAIN INHIBITOR - Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy. | 2015-11-05 |
20150315185 | PYRROLO[2,3-b]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-b]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS - The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer. | 2015-11-05 |