45th week of 2008 patent applcation highlights part 33 |
Patent application number | Title | Published |
20080274424 | Positive photosensitive element comprising vinyl polymers - A positive-working photosensitive composition for use in making an imageable element comprises one or more vinyl copolymers wherein said vinyl copolymer are homopolymer or copolymer containing monomers comprising at least two functional groups such as HOOC—C═C—CONH—R, and may further comprise a converter substance for converting radiation into heat. The converter substance may be selected to have an absorption spectrum that is optimized to absorb at the wavelength of imaging radiation. The composition may be coated onto a suitable substrate to create a lithographic printing precursor. The precursor may be imagewise irradiated with radiation and optionally developed with a developer liquid to produce a lithographic printing master. A positive-working lithographic printing precursor may be prepared using the composition. | 2008-11-06 |
20080274425 | POSITIVE WORKING LIGHT SENSITIVE PLANOGRAPHIC PRINTING PLATE MATERIAL - Disclosed is a positive working light sensitive planographic printing plate material comprising an aluminum support and provided thereon, a lower layer and an upper layer in that order, at least one of the upper and lower layers containing a fluoroalkyl group-containing acryl resin, wherein the upper layer contains an alkali soluble resin and a light-to-heat conversion material, and the lower layer contains an alkali soluble resin and an acid decomposable compound represented by the following formula (1), | 2008-11-06 |
20080274426 | CHEMICALLY AMPLIFIED RESIST COMPOSITION - The present invention provides a chemically amplified resist composition comprising:
| 2008-11-06 |
20080274427 | Method of Making a Lithographic Printing Plate - A method of making a lithographic printing plate includes the steps of: a) providing a lithographic printing plate precursor comprising including (i) a support having a hydrophilic surface or which is provided with a hydrophilic layer, (ii) a coating on the support, including a photopolymerizable layer and, optionally, an intermediate layer between the photopolymerizable layer and the support, wherein the photopolymerizable layer includes a polymerizable compound, a polymerization initiator, and a binder, b) image-wise exposing the coating in a plate setter, c) heating the precursor in a pre-heating unit, d) treating the precursor in a gumming station, including at least a first gumming unit, by applying a gum solution to the coating of the precursor, thereby removing the non-exposed areas of the photopolymerizable layer from the support, and wherein the steps (c) and (d) are carried out off-press in the pre-heating unit and the first gumming unit, and wherein the pre-heating unit and the first gumming unit are coupled to each other by a mechanical plate conveying device or are integrated in a single apparatus. | 2008-11-06 |
20080274428 | Method of Making a Lithographic Printing Plate - A method of making a lithographic printing plate includes the steps of: a) providing a lithographic printing plate precursor including (i) a support having a hydrophilic surface or which is provided with a hydrophilic layer, (ii) a coating on the support including a photopolymerizable layer, a top layer and, optionally, an intermediate layer between the photopolymerizable layer and the support, wherein the photopolymerizable layer includes a polymerizable compound, a polymerization initiator, and a binder, b) image-wise exposing the coating in a plate setter, c) optionally, heating the precursor in a pre-heating unit, and d) treating the precursor in a gumming station, the gumming station including a first and at least a second gumming unit, wherein the precursor is washed in the first gumming unit by applying a gum solution to the coating thereby removing at least a portion of the top layer, and wherein, subsequently, the precursor is developed in the second gumming unit with a gum solution thereby removing non-exposed areas of the photopolymerizable layer from the support and gumming the plate in a single step. | 2008-11-06 |
20080274429 | Aqueous treatment of on-press developable lithographic printing plate - A method of treating an on-press developable lithographic printing plate with an aqueous treating solution after imagewise exposure and before on-press development is described. The plate comprises on a substrate a photosensitive layer developable with ink and/or fountain solution and capable of hardening upon exposure to a radiation. The plate is imagewise exposed with a radiation, overall treated with a treating solution to cause at least one chemical or physical change in the photosensitive layer or on the substrate surface, and then on-press developed with ink and/or fountain solution. Such a treatment allows improvement on the performance of the imagewise exposed plate by, for example, improving the white light stability, forming visible imaging, increasing the hydrophilicity of the substrate, or increasing the developability of the photosensitive layer. | 2008-11-06 |
20080274430 | UV RADIATION BLOCKING PROTECTIVE LAYERS COMPATIBLE WITH THICK FILM PASTES - This invention relates to novel compositions comprising a protective polymer layer and a UV blocking agent. This is used in the fabrication of electronic devices using thick film pastes. The present invention is also an electronic device fabrication process using the compositions. The protective polymer layer is fabricated from materials, which are insoluble after irradiation in the ester-type solvents contained in the thick film paste. By appropriate selection of protective film polymers, the protective film can be compatible with the thick film paste and can be further used to shield portions of the thick film paste from UV irradiation. | 2008-11-06 |
20080274431 | Resist pattern swelling material, and method for patterning using same - To provide a method for easily forming microscopic patterns exceeding the limit of exposure in the patterning technique utilizing the photolithography method in the vacuum deep ultraviolet ray region, a resist pattern swelling material is comprised by mixing a water-soluble or alkali-soluble composition comprising a resin and a cross linking agent and any one of a non-ionic interfacial active agent and an organic solvent selected from a group of the alcohol based, chain or cyclic ester based, ketone based, chain or cyclic ether based organic solvents. | 2008-11-06 |
20080274432 | SILICONE-CONTAINING FILM-FORMING COMPOSITION, SILICON-CONTAINING FILM, SILICON-CONTAINING FILM-BEARING SUBSTRATE, AND PATTERNING METHOD - A silicon-containing film is formed from a heat curable composition comprising (A-1) a silicon-containing compound obtained through hydrolytic condensation of a hydrolyzable silicon compound in the presence of an acid catalyst, (A-2) a silicon-containing compound obtained through hydrolytic condensation of a hydrolyzable silicon compound in the presence of a base catalyst, (B) a hydroxide or organic acid salt of Li, Na, K, Rb or Ce, or a sulfonium, iodonium or ammonium compound, (C) an organic acid, (D) a cyclic ether-substituted alcohol, and (E) an organic solvent. The silicon-containing film ensures effective pattern formation, effective transfer of a photoresist pattern, and accurate processing of a substrate. | 2008-11-06 |
20080274433 | Rinse Treatment Method and Development Process Method - A rinsing method for performing a rinsing process on a substrate, after a developing process is performed on a light-exposed pattern disposed thereon, includes a step (STEP | 2008-11-06 |
20080274434 | GAS APPLIANCE - A coupling for attaching a fuel canister to an appliance such as a torch is provided that comprises a first connector on the canister. The first connector comprises a first set of screw threads where the first set of screw threads are interrupted to define a shape. A second connector is provided on the appliance or torch where the second connector comprises a locking element. The locking element has a matching shape that matches the shape such that the locking element closely receives the first connector when the first connector is in a first orientation relative to the second connector. A method of using the coupling is also provided where the appliance is rotated relative to the canister less than 360 degrees. | 2008-11-06 |
20080274435 | Crimping Pliers, Especially for Orthodontic Applications - Orthodontic crimping pliers include a first member having a first handle at a first end and a first jaw at a second end, the first jaw having a first flat edge, a second member having a second handle at a first end and a second jaw at a second end having a second flat edge and a pivot connecting the first and second members and allowing the first and second members to pivot with respect to one another so that pivoting the first handle towards the second handle causes the first jaw and the second jaw to move from an open position with the first and second jaws spaced apart toward a closed position with the first flat edge of the first jaw and second flat edge of the second jaw adjacent one another. In the closed position, the first flat edge of the first jaw and second flat edge of the second jaw are parallel and adjacent one another over a width of 0.005 to 0.015 inches. | 2008-11-06 |
20080274436 | Optically regulated dental light unit - A dental system includes a light source, a power supply that adjusts a quantity of light produced by the light source, a measuring device that measures a quantity of light received from the light source, an input, through which user data, including a desired quantity of light, can be entered, and a controller which, together with the measuring device, forms at least part of a feedback loop. The controller receives the user data and communicates with the measuring device and the power supply so that the power supply adjusts a quantity of light emitted by the light source. As a result, the quantity of light received from the light source becomes substantially equal to the desired quantity of light. | 2008-11-06 |
20080274437 | METHOD AND APPARATUS FOR IDENTIFYING TOOTH-COLOURED TOOTH FILLING RESIDUES - A tooth is irradiated with light ( | 2008-11-06 |
20080274438 | OZONE TRAY - Apparatus for the treatment of iatropgenic enamel damage includes a tray for connection to a handpiece for delivering ozone to teeth. A port in the tray is provided for receiving the ozone. The tray includes a resilient edge for sealably engaging the tooth/gums to prevent escape of ozone therepast. | 2008-11-06 |
20080274439 | Dental device for use in the obturation of a root canal - Kit-of-parts containing
| 2008-11-06 |
20080274440 | Dental Implant Abutment - A dental implant abutment for attaching a dental prosthesis within a patient's mouth. The abutment is a single unit structure fabricated of a ceramic material, multicolored throughout to match the color of the dental prosthesis, the surrounding dentition and the surrounding gingival tissue. | 2008-11-06 |
20080274441 | METHOD AND APPARATUS FOR MANUFACTURING AND CONSTRUCTING A PHYSICAL DENTAL ARCH MODEL - A method produces a physical dental arch model based on a three-dimensional (3D) digital dental arch model. The method includes smoothening the digital dental arch model to make the digital dental arch model suitable for CNC based manufacturing, segmenting the digital dental arch model into at least two manufacturable digital components, producing manufacturable physical components using Computer Numerical Control (CNC) based manufacturing in accordance with the manufacturable digital components, and assembling the manufacturable physical components to form the physical dental arch model. | 2008-11-06 |
20080274442 | Laser curable polymerisable composition for the protection of hard tissue - One-component heat-curable sealant composition for the protection of exposed dental surfaces, comprising
| 2008-11-06 |
20080274443 | System and method for foreign language processing - The present disclosure relates to foreign language instruction and translation methods. A system is provided which utilizes tonal and rhythm visualization components to allow a person to “see” their words as they attempt to speak a foreign language or a specific regional dialect. The system is also applicable to foreign language translation systems and allows students to improve their pronunciation by responding to visual feedback which incorporates both color and shape. The system may comprise a step-by-step instruction method, along with recording and playback features. Certain embodiments incorporate statistical analysis of student progress, remote access for teacher consultation, and video games for enhancing student interest. | 2008-11-06 |
20080274444 | ELECTRONIC DATA EXCHANGE - In an aspect, the specification provides a system for exchange of data comprising a plurality of questioner workstations connectable to a network and a plurality of answerer workstations connectable to the network. The system also provides a data exchange engine connected to the questioner workstations and the answerer workstations via the network. The data exchange engine is configured to receive at least one question from at least one of the questioner workstations and to present the at least one question to at least one of the answerer workstations. The data exchange engine is also configured to maintain a compensation pool associated with the question. The data exchange engine is further configured to collect answers to the question and present the answers to the questioner. The data exchange engine is further configured to distribute at least a portion of the compensation pool to an answerer associated with at least one of the answerer workstations. The data exchange engine is further configured to receive a quality rating for each of the answers. The compensation pool is distributed to the answerer based on the answerer according to the ranking quality. | 2008-11-06 |
20080274445 | Reversal Magnetic Display Panel - A reversal magnetic display panel where the numbers of writes/erases repeated until the micro magnets in a dispersion liquid sealed in multiple small cells formed between substrates sediment in the lower part of the small cells by repeated writes/erases when the reversal magnetic display panel is used in a vertical position are increased and a favorable display/erase performance is achieved. Between substrates, a dispersion liquid containing a dispersion medium and a thickening agent as main components and further containing micro magnets the both sides of each of which are differently colored are sealed in. Writing is constituted by difference in contrast between the color of the reversed micro magnets and the color of the non-reversed ones. Hollow particles are mixed with the micro magnets so as to reduce the ratio of the specific gravity of the micro magnets to that of the liquid. The residual magnetization per unit mass of the micro magnets is 1.0 to 23.1 A·m | 2008-11-06 |
20080274446 | Cryopreserved human neuronal cultures - Cryopreserved cultures of post-mitotic neuronal or neural-like cells are provided having a viability after thaw of greater than 10%, typically greater than 50%. Once thawed, the cells are capable of further differentiation. In one embodiment, less than 20% of the cryopreserved cells are self-proliferating cells. The cells can be provided in a kit including a container of the cryopreserved neuronal or neural-like cells, optionally including additional cell culture reagents and materials. Method for preparing the cryopreserved neuronal or neural-like cells derived from embryonic stem cells, preferably human embryonic stem cells, are also provided. | 2008-11-06 |
20080274447 | Method and Apparatus for Implementing Threshold Based Correction Functions for Biosensors - A biosensor system, method and apparatus are provided for implementing threshold based correction functions for biosensors. A primary measurement of an analyte value is obtained. A secondary measurement of a secondary effect is obtained and is compared with a threshold value. A correction function is identified responsive to the compared values. The correction function is applied to the primary measurement of the analyte value to provide a corrected analyte value. The correction method uses correction curves that are provided to correct for an interference effect. The correction curves can be linear or non-linear. The correction method provides different correction functions above and below the threshold value. The correction functions may be dependent or independent of the primary measurement that is being corrected. The correction functions may be either linear or nonlinear. | 2008-11-06 |
20080274448 | Method for detecting a hydrophobic region of a target substance - An object of the present invention is to provides a method for detecting a hydrophobic region of a target substance that is capable of forming a hydrophobic region, such as a protein, which can detect a fluorescent analyte with high sensitivity with the use of a simple detection apparatus. The present invention provides a method for detecting a hydrophobic region of a target substance which comprises steps of allowing a target substance capable of forming a hydrophobic region to come into contact with a chemiluminescent substance, and assaying chemiluminescence. | 2008-11-06 |
20080274449 | ASSAY FOR DETECTION OF HUMAN PARVOVIRUS B19 NUCLEIC ACID - Nucleic acid oligomers specific for human parvovirus B19 genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus B19 nucleic acid in biological specimens is disclosed. Compositions for detecting the presence of parvovirus B19 genomic DNA in human biological specimens are disclosed. | 2008-11-06 |
20080274450 | Methods and applications of molecular beacon imaging for identifying and validating genomic targets, and for drug screening - A method for characterizing the gene expressions of a sample of cells of a living subject, where the sample of cells is characterized by one or more marker sequences. In one embodiment, the method includes the steps of providing one or more types of molecular beacons, each type of molecular beacons designed to have a corresponding probe sequence complementary to one of the one or more marker sequences and an emitter capable of emitting photons of a unique color such that when one of the type of molecular beacons targets the one of the one or more marker sequences the sample of cells, the emitter of the molecular beacon emits photons of the unique color, thereby generating a photon signal of the unique color; treating the sample of cells with the one or more types of molecular beacons; and detecting photon signals of one or more colors of the sample of cells so as to characterizing the gene expressions of the sample of cells, wherein the one or more types of molecular beacons are designed such that the photon signals of the one or more colors are detectable without a need of signal amplification. | 2008-11-06 |
20080274451 | Body for flow-through cells and the use thereof - A system of flow-through cells is obtained by assembling a body with a base plate. The body has a first spring element and a first stop, disposed on opposite end sections of the body, at least one second spring element and a corresponding second stop, disposed on opposite faces of the body, and at least one support element and at least one retaining element, which are adapted for the exact positioning of the body in the receiving openings of a support in three directions. | 2008-11-06 |
20080274452 | Process For Large Scale Production Of Plasmid Dna By E.Coli Fermentation - The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of | 2008-11-06 |
20080274453 | Diagnostics and therapeutics for macular degeneration - The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial wall disruptive disorder, including an aneurysm. In one embodiment, the invention provides therapeutics for treating macular degeneration comprising delivering to a subject an agent useful for treating an arterial wall disruptive disorder, including an aneurysm. | 2008-11-06 |
20080274454 | Reversible and Chemically Programmable Micelle Assembly With Dna Block-Copolymer Amphiphiles - The present invention is directed to amphiphilic block copolymers. More particularly the present invention is directed to amphiphilic block copolymers comprising a polynucleotide block and a hydrophobic polymer block, to micelles formed from the block copolymers, and to methods of using the micelles. | 2008-11-06 |
20080274455 | Use Of Genes As Molecular Markers In Diagnosis Of Schizophrenia And Diagnostic Kit For The Same - Drug-naive and drug-free schizophrenic PBL were screened to identify additional markers that are differentially expressed compared to healthy individuals using microarray and quantitative real-time PCR (QRT-PCR) techniques. Genes for dopamine D | 2008-11-06 |
20080274456 | Methods and Compositions for Modifying Gene Regulation and Dna Damage in Ageing - The invention relates to gene regulation in ageing, and age-related cognitive decline. The invention, in particular relates to methods for screening a subject for a propensity to develop diseases associated with oxidative stress, and for age-related conditions, by examining the up-regulation and/or down-regulation of at least one gene associated within the central nervous system. | 2008-11-06 |
20080274457 | METHODS FOR DIFFERENTIATING MALIGNANT FROM BENIGN THYROID TISSUE - Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided. | 2008-11-06 |
20080274458 | NUCLEIC ACID QUANTITATION METHODS - The invention relates to a method of determining the amount of a target nucleic acid sequence in a sample, the method comprising: obtaining multiple distinguishable amplicons of the target nucleic acid sequence, each comprising a distinguishing tag and a target portion; amplifying the amplicons in a single reaction volume; and detecting nucleic acids amplified from the amplicons. Detection of the distinguishable amplicons can be varied in each of the steps of the method, which expands the dynamic range of the nucleic acid quantification methods and improves the reliability and accuracy of the methods. | 2008-11-06 |
20080274459 | METHOD FOR COLLECTING AND STORING BIOLOGICAL MATERIALS - A method for collecting and storing biological material includes the steps of obtaining a patient identity of a patient and a biological material from a patient. A DNA identity analysis is performed to establish a DNA identity for the patient. The DNA identity is associated with the patient identity and the biological material. The biological material is stored in a preserving environment, and the patient identity and the DNA identity are stored in a database. A request for the biological material is received from a requestor purporting to have the patient identity. A DNA sample from said requestor is obtained. A DNA identity analysis is performed on the DNA sample from the requestor to obtain a DNA identity of the requestor. The DNA identity of the requestor is then compared to the stored DNA identity of the patient, and if the DNA identities match, the biological material is provided to the requestor. | 2008-11-06 |
20080274460 | Common allele on chromosome 9 associated with coronary heart disease - Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has had RA-CHR9 allel, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). | 2008-11-06 |
20080274461 | Perinucleolar Compartment Markers for Cancer - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 2008-11-06 |
20080274462 | Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases - Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and microsatellite analysis. | 2008-11-06 |
20080274463 | Method for quantifying biomolecules conjugated to a nanoparticle - Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, proteins, haptens, nucleic acids, oligonucleotides, DNA, RNA, and combinations thereof. A single type of biomolecule may be conjugated to the nanoparticle, more than one biomolecule of a particular class may be conjugated to the nanoparticle, or two or more classes of biomolecules may be conjugated to the nanoparticle. Certain disclosed embodiments comprise enzymatically or chemically digesting a biomolecule conjugated to the nanoparticle, or displacing a biomolecule using ligand-exchange chemistry. Where biomolecule concentrations are determined, any technique suitable for determining biomolecule concentration can be used, such as spectrophotometric techniques, including measuring tryptophan fluorescence and using a standard fluorescence intensity versus biomolecule concentration curve. | 2008-11-06 |
20080274464 | Gene Detecting Method - Disclosed is a gene detecting method for determining mutation of a specific base or presence/absence of a specific base in a target gene. There are provided a the target gene sample and a control gene sample having a base sequence which is wild-type or standard-type with respect to the target gene. The method comprises steps of (i) independently subjecting the target gene sample and the control gene sample to a PCR reaction for amplification, using primers having an RNA polymerase promoter sequence at the 5′-end thereof, (ii) independently subjecting the double-stranded DNAs produced by said PCR reaction from the target gene sample and from the control gene sample, to an in vitro transcription reaction to form a single-stranded RNA, (iii) independently hybridizing the single-stranded RNAs with a fluorescence-labeled probe composed of a single-stranded DNA having a base sequence complementary to at least part of the base sequence of the control gene and being combined with a fluorescent dye, to form an RNA/DNA hybrid, and then (iv) comparing the fluorescence intensity of the RNA/DNA hybrid derived from the target gene sample with that of the RNA/DNA hybrid derived from the control gene sample. | 2008-11-06 |
20080274465 | Method for Breast Cancer Diagnosis/Prognosis - The present invention relates to a method for breast cancer diagnosis/prognosis comprising the following steps:
| 2008-11-06 |
20080274466 | Enrichment Through Heteroduplexed Molecules - The present invention relates to the enrichment of specific target sequences Enrichment can be achieved through the formation of a heteroduplex that includes the specific target sequence and then the specific cleavage of the heteroduplex. A binding moiety is then added to the cleaved heteroduplex, allowing for the subsequent manipulation of the specific target sequence in the heteroduplex. | 2008-11-06 |
20080274467 | Novel Therapeutic Targets in Cancer - The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer. | 2008-11-06 |
20080274468 | NOVEL MEANS FOR THE DIAGNOSIS AND THERAPY OF CTCL - The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL. | 2008-11-06 |
20080274469 | C-Kit Oncogene Mutations in Melanoma - The present invention provides methods of detecting c-KIT-dependent-melanoma for diagnostic and prognostic purposes. The invention further provides methods of treating such melanoma by inhibiting c-KIT. | 2008-11-06 |
20080274470 | NON-INVASIVE DETECTION OF ENDOMETRIAL CANCER - The present invention provides a non-invasive method of obtaining a sample of endometrial cells for use in the diagnosis of endometrial cancer, as well as methods and kits for diagnosing, determining the prognosis of, and monitoring endometrial cancer. | 2008-11-06 |
20080274471 | Methods for detecting an increased risk for coronary heart disease - The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease. | 2008-11-06 |
20080274472 | Novel kinases and uses thereof - Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. | 2008-11-06 |
20080274473 | Amyloid binding assays - Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to the brain tissue sample; and (c) determining whether the putative binder binds to the A-beta species. | 2008-11-06 |
20080274474 | Authentication Method and System for Authenticating Security Documents, Security Document and Security Element - An authentication system for authenticating security documents contains at least an enzyme and a substrate and any co-enzymes and/or co-factors needed, capable of an enzymatic conversion. This conversion leads to a detectable change. The security-document contains at least one of the enzyme and the substrate. According to the invention the genetic information for the enzyme is derived from an extremophilic micro-organism. A security document for use in the authentication system and method is also described. | 2008-11-06 |
20080274475 | HLA-E BINDING - The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound affects the binding of HLA-E to the cells. The HLA-E property of binding to CD94/NKG2 receptors on NK cells and a subset of CD8+ T cells is useful for targeting CD94/NKG2+ cells for a variety of purposes such as identification, isolation, killing or inactivation. | 2008-11-06 |
20080274476 | Assay Method - There is disclosed a method for determining the activity of gamma-secretase in a text subject, using a biological sample from the subject. | 2008-11-06 |
20080274477 | Forms of Factor Xiia - A 53 Kd novel form of factor XIIa and related products, including nucleic acid molecules, monoclonal and polyclonal antibodies and hybridoma cell lines. Also assays for a 53 Kd form of factor XIIa and uses of said assays in diagnostic and prognostic methods, for example in the prediction of survival following myocardial infarction. | 2008-11-06 |
20080274478 | NOVEL AROMATIC PRENYLTRANSFERASES, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR - In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from | 2008-11-06 |
20080274479 | Assay of Ubiquitinization of Synoviolin and Use Thereof in Screening - The present invention relates to an assay method for determining a auto-ubiquitination activity of synoviolin, comprising reacting synoviolin and ubiquitin in a reaction system containing them and determining an amount of ubiquitin binding to synoviolin, to a method of screening a substance capable of regulating such an activity, and to a kit for auto-ubiquitination assay of synoviolin. | 2008-11-06 |
20080274480 | Botulinum Toxin Type a Immunoresistant Assay - The present specification discloses methods for determining Botulinum Toxin Type A immunoresistance in a mammal by detecting the amount of BoNT/A toxin-BoNT/A receptor complexes or the amount of free BoNT/A present or absent in a sample. | 2008-11-06 |
20080274481 | Methods for diagnosing ovarian cancer - The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means. | 2008-11-06 |
20080274482 | BETA 1 INTEGRIN ACTIVATION AS A MARKER FOR ASTHMA - Methods are provided in which β | 2008-11-06 |
20080274483 | Method for Diagnosing Renal Disorder, Hemolytic Uremic Syndrome and Enterohemorrhagic Infectious Disease Caused by Escherichia Coli - Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic | 2008-11-06 |
20080274484 | Method for Diagnosing Renal Disorder, Hemolytic Uremic Syndrome and Enterohemorrhagic Infectious Disease Caused by Escherichia Coli - Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic | 2008-11-06 |
20080274485 | Enhancing a Luminescent Signal - Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of signal by varying the composition of the buffer. One or more of the following parameters have been varied: the presence or absence of EDTA, the concentration of NaCl, the concentration of coelenterazine, the evaluation of ionic and non-ionic detergent, the amount of detergent, how the detergent has been added and the time over which the signal has been recorded. Also disclosed are dual reporter systems. | 2008-11-06 |
20080274486 | Method of Assaying Fad Synthetase - The present invention relates to methods of determining activity of flavin adenine dinucleotide (FAD) synthetase, and methods of identifying compounds that modulate the activity of this enzyme. | 2008-11-06 |
20080274487 | Use of Serum/Glucocorticoid-Regulated Kinase - The invention relates to the use of an SGK protein, a functional derivative or fragment thereof, or a nucleic acid coding for one such protein, fragment or derivative, in order to discover active ingredients for the prevention or treatment of degenerative cartilage changes. | 2008-11-06 |
20080274488 | Covalent tethering of functional groups to proteins and substrates therefor - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 2008-11-06 |
20080274489 | Methods for detecting organisms and enzymatic reactions using raman spectroscopy - The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. The present disclosure can also be used to measure enzyme-kinetics. | 2008-11-06 |
20080274490 | PD-1, a receptor for B7-4, and uses therefor - Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an activating antibody that recognizes PD-1, a form of B7-4 that binds to an inhibitory receptor, and a small molecule that binds to PD-1. Agents which are useful for inhibiting signaling via PD-1 to upregulate an immune response include a blocking antibody that recognizes PD-1, a non-activating form of B7-4, an antibody that recognizes B7-4, and a soluble form of PD-1. Also disclosed is a method for modulating the interaction of B7-4 with an inhibitory receptor on an immune cell. The method comprises contacting an antigen presenting cell which expresses B7-4 with an agent such as a form of B7-4, a form of PD-1, or an agent that modulates the interaction of B7-4 and PD-1. Also disclosed is a method for inhibiting activation of an immune cell via a non-apoptotic mechanism by increasing the activity or expression of PD-1 in the immune cell. The disclosed methods for modulating an immune response are useful, for instance as therapeutic treatment of a subject with conditions that would benefit from immune response modulation. For instance, a condition such as a tumor, a neurological disease, or an immunosuppressive disease, would be treated by upregulating an immune response, and conditions such as a transplant, an allergy, or an autoimmune disorder would benefit from downregulation of an immune response. Assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule are also disclosed. Further disclosed are a vaccine and also other compositions which contain agents that modulate signaling via PD-1. | 2008-11-06 |
20080274491 | Modulation of the Integrin Linked Kinase Signaling Pathway to Promote Cardiac Cell Proliferation and Self-Renewal - Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK signaling pathway is also used as a means for cardiac stem cell proliferation and self-renewal | 2008-11-06 |
20080274492 | Detection of platinum group metals with fluorophores via allylic oxidative insertion - A method of detecting platinum group metals in a sample is provided. The method comprises the step of contacting the sample with a fluorophore capable of undergoing allylic ether or allylic ester cleavage. The fluorophore has an oxygen-protected moiety, the protecting group having an allylic functionality. A reducing agent and optionally a solubilizer are also added to the sample. Very low levels of platinum group metals such as palladium and platinum can be detected in a sample. | 2008-11-06 |
20080274493 | APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING - The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel. | 2008-11-06 |
20080274494 | METHOD AND APPARATUS FOR CO2 SEQUESTRATION - A method and apparatus for growing algae for sequestering carbon dioxide and then harvesting the algae includes a container for a suspension of algae in a liquid and a bioreactor having a translucent channel in fluid communication with the container to absorb CO | 2008-11-06 |
20080274495 | Diagnostic Method for Testing Hydration and Other Conditions - Methods for the non-invasive collection of a liquid sample in small quantities, such as urine for testing hydration in infants and incontinent adults, directly at the source of that sample, isolation of the collected sample from a testing site, the transportation of that sample to a site for testing contained within the device itself, and the selective application of some or all of the specimen to a testing apparatus contained within the device itself, with a minimum of specimen handling required. Other aspects include a method and device for facilitating the reading of the result of the specimen test by a skilled or unskilled user, including means for determining that no adequate sample has been delivered to the testing site. | 2008-11-06 |
20080274496 | Methods, Reagents and Instrumentation for Preparing Impregnated Tissue Samples Suitable for Histopathological and Molecular Studies - A process and kit for the production of paraffin sections of biological tissue, especially for molecular pathology studies, is described. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen matrix in a third step. The specimen can then be further embedded in a casting supporting matrix according to the standard procedures followed by any local pathology or research laboratory. The method is uncomplicated, requires little hands-on time, is reproducible and is standardized thereby limiting cross-centre pre-analytical variance. A bio-indicator system for measuring the degree of crosslinking is also disclosed. | 2008-11-06 |
20080274497 | RECOMBINANT PROTEIN PRODUCTION IN A HUMAN CELL - Methods and compositions for the production of recombinant proteins in a eukaryotic cell line are disclosed. The methods and compositions are particularly useful for generating stable expression of recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins may have advantageous properties in comparison with their counterparts produced in non-human systems such as Chinese hamster ovary cells. | 2008-11-06 |
20080274498 | Methods for producing modified glycoproteins - Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man | 2008-11-06 |
20080274499 | Polypeptides having alpha-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 2008-11-06 |
20080274500 | Promoter variants for expressing genes in a fungal cell - The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances. | 2008-11-06 |
20080274501 | METHOD OF PURIFYING ACIDIC PROTEINS EXPRESSED IN PLANTS - The present invention provides a rapid and relatively simple process for purification of acidic proteins expressed in tobacco cells. The process comprises three main purification steps: precipitation with polyethyleneimine, column chromatography with a hydrophobic interaction resin, and column chromatography with hydroxyapatite. The process provides pure or essentially pure protein at a very high yield. | 2008-11-06 |
20080274502 | Bacillus Thuringiensis CryET33 and CryET34 Compositions and Uses Therefor - Disclosed are | 2008-11-06 |
20080274503 | Modified Shine-Dalgarno Sequences and Methods of Use Thereof - Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention, compounds and methods for high efficiency production of soluble protein in prokaryotic systems are provided. | 2008-11-06 |
20080274504 | SOLUBLE ErbB3 RECEPTOR ISOFORMS - The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to ErbB2/ErbB3 heterodimers on the cell surface of breast carcinoma cells. The present invention also uses p85-sErbB3 to inhibit heregulin-induced phosphorylation of ErbB2, ErbB3, and ErbB4 in cells, as a negative regulator of heregulin-stimulated signal transduction, and as a block for cell growth. The present invention is also directed to nucleic acids and expression vectors encoding p85-sErbB3, host cells harboring such expression vectors, and methods of producing the protein. The present invention discloses a method of therapeutically treating human malignancies associated with heregulin-mediated cell growth such as breast and prostate cancer. | 2008-11-06 |
20080274505 | Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof - The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention. | 2008-11-06 |
20080274506 | POLYPEPTIDE VARIANTS WITH ALTERED EFFECTOR FUNCTION - The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof. | 2008-11-06 |
20080274507 | METHODS OF PROTEIN PRODUCTION USING ANTI-SENESCENCE COMPOUNDS - Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of an anti-senescence compound exhibit decreased levels of high molecular weight aggregates in the cell culture medium. | 2008-11-06 |
20080274508 | Expression system for enhancing solubility and immunogeneicity of recombinant proteins - Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein. The chimeric protein contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein that contains a protein transduction domain (PTD) or a fragment thereof having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment that contains a J-domain or a fragment thereof having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment that contains a target protein or polypeptide. | 2008-11-06 |
20080274509 | PROCESS FOR PREPARING SUGAR-CONTAINING HYDROLYZATES FROM LIGNOCELLULOSE - A sugar-containing hydrolyzate is produced from a lignocellulose-containing material by a) pretreating the lignocellulose-containing material with a chemical compound selected from sulphuric acid, alkali, peroxodisulphates, potassium peroxide, potassium hydroxide, and mixtures thereof, in the presence of water, thereby obtaining an aqueous phase, and b) after removing of the aqueous phase and washing the resulting product, treating said product with an enzyme suitable for hydrolysis in the presence of water, thereby obtaining a hydrolyzate, the hydrolyzate being suitable as a carbon source for fermentation. | 2008-11-06 |
20080274510 | Synthetic genes - The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important polyketide compounds. | 2008-11-06 |
20080274511 | DEVICE FOR CARRYING OUT CHEMICAL OR BIOLOGICAL REACTIONS - The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a heating device for heating the reaction vessel receiving element, and a cooling device for cooling the reaction vessel. The invention is characterized by the fact that the reaction vessel receiving element is divided into several segments. The individual segments are thermally decoupled from one another, and each segment is assigned a heating device which may be actuated independently of the others. By means of the segmentation of the reaction vessel receiving element, it is possible for zones to be set and held at different temperatures. Because the reaction vessel receiving element is suitable for receiving standard microtiter plates, the device according to the invention may be integrated in existing process sequences. | 2008-11-06 |
20080274512 | Reagent Transfer Device - A device for transferring reagents in solid or liquid form from one place to another on an apparatus, said device comprising an upper portion, adapted to be held, and a lower portion adapted to hold reagents in solid or liquid form, in an available manner. For example, the reagents may be held within a cage structure or retained on an outer surface of the lower portion. Methods for using the device, as well as apparatus for use in conjunction with the device are also described and claimed. | 2008-11-06 |
20080274513 | Method and Device for Conducting Biochemical or Chemical Reactions at Multiple Temperatures - Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. The devices comprise a microfluidics apparatus comprising appropriate actuators capable of moving reaction droplets or reaction volumes through the various reaction zones. | 2008-11-06 |
20080274514 | PENETRABLE CAP HAVING SPACED-APART GROOVES - A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap. | 2008-11-06 |
20080274515 | Animal component free meningococcal polysaccharide fermentation and seedbank development - Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times the level observed with batch fermentation. This process is used successfully to produce polysaccharides of | 2008-11-06 |
20080274516 | Psod Expression Units - The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms. | 2008-11-06 |
20080274517 | PROCESS FOR THE MANUFACTURE OF NON-STEROIDAL ANTI-INFLAMMATORY AGENTS AND INTERMEDIATES THEREOF - The current invention describes novel chiral synthetic routes and intermediates for the manufacture of chiral anti-inflammatory agents of general formula VIII | 2008-11-06 |
20080274518 | Polypeptides and Biosynthetic Pathways for the Production of Monatin and its Precursors - Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions. | 2008-11-06 |
20080274519 | FLAVONOID CONCENTRATES - A method of producing a flavonoid aglycone concentrate from plant material containing a suitable flavonoid glycoside and/or conjugate thereof comprising the steps of:
| 2008-11-06 |
20080274520 | Novel Gene Sms 37 - The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C. | 2008-11-06 |
20080274521 | DELTA-5 DESATURASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS - The present invention relates to Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ5 desaturases in oleaginous yeast are disclosed. | 2008-11-06 |
20080274522 | METHOD FOR THE PRODUCTION OF 2-BUTANONE - A method for the production of 2-butanone by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanone product. | 2008-11-06 |
20080274523 | PRODUCTION OF ISOPRENOIDS - The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically modified host cells. | 2008-11-06 |