45th week of 2012 patent applcation highlights part 34 |
Patent application number | Title | Published |
20120282266 | ANTI-NEOPLASTIC USES OF ARTEMIN ANTAGONISTS - The invention relates to methods for the prophylaxis and treatment of breast cancer using one or more antagonists of artemin function, such as anti-artemin polynucleotides or anti-artemin antibodies and antibody fragments, and uses of these antagonists. In particular, the invention relates to the resensitisation of therapy-resistance breast cancer cells to anti-cancer therapies by antagonism of artemin functionality. | 2012-11-08 |
20120282267 | CATHEPSIN INHIBITORS FOR THE TREATMENT OF BONE CANCER AND BONE CANCER PAIN - The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer. | 2012-11-08 |
20120282268 | Novel Cell Wall Components of Enterococci and Uses Thereof - The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection. | 2012-11-08 |
20120282269 | Anti-IL-23 Antibodies - The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 2012-11-08 |
20120282270 | FORMULATION OF HUMAN ANTIBODIES FOR TREATING TNF-ALPHA ASSOCIATED DISORDERS - A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability. | 2012-11-08 |
20120282271 | METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF MACROPHAGE-STIMULATING PROTEIN - The invention provides methods and compositions for modulating hepsin activity and the MSP/Ron pathway, in particular by regulating pro-MSP activation by hepsin. | 2012-11-08 |
20120282272 | NOVEL TARGET IN THE TREATMENT OF CYTOKINE RELEASE SYNDROME - A novel therapeutic and diagnostic target in the treatment of Cytokine Release Syndrome is provided. More specifically, a novel target is disclosed in the treatment of CRS occurring with diseases such as bacterial and viral infection. as well as adverse reaction in drug therapy. | 2012-11-08 |
20120282273 | RECOMBINANT ANTIBODIES AGAINST H1N1 INFLUENZA - Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine H1N1 virus. The antibody is also able to cure mice in a therapeutic setting when treated as late as up to 60 hours (2.5 days) after infection with swine H1N1 virus. Also described are recombinant forms of this antibody. | 2012-11-08 |
20120282274 | TARGETING OF THE C-TERMINAL SEGMENT OF C.DIFFICILE TOXIN B FOR IMPROVED CLINICAL DIAGNOSIS, PREVENTION, AND TREATMENT - The disclosure provides specific and sensitive anti-toxin B antibodies and fragments thereof suitable for diagnosing | 2012-11-08 |
20120282275 | METHODS AND COMPOSITIONS FOR REGULATION OF NEUROLOGICAL CONDITIONS - The invention relates to methods and compositions for regulation of neurological conditions. In particular, methods and compositions for the modulation of the chemokine receptor 1 (CX3CR1) and its ligands are described. | 2012-11-08 |
20120282276 | BIOMARKERS PREDICTIVE OF PROGRESSION OF FIBROSIS - The present invention provides methods and kits for prognosing the progression of fibrosis in a subject having fibrosis, as well as methods for identifying a compound that can slow down the progression of fibrosis in a subject having fibrosis, methods of monitoring the effectiveness of a therapy in reducing the progression of fibrosis in a subject having fibrosis, methods of selecting a subject for participation in a clinical trial for the treatment of fibrosis, and methods for inhibiting progression of fibrosis in a cell or a subject having fibrosis. The methods are based on determining the level of Toll-like recepter 9 (TLR9). | 2012-11-08 |
20120282277 | Method for Treating Arteriosclerosis - The invention relates to a method for identifying substances with antiapoptotic activity, where
| 2012-11-08 |
20120282278 | ANTI P2X7 RECEPTOR ANTIBODIES AND FRAGMENTS THEREOF - The invention relates to an antigen binding site for binding to a P2X | 2012-11-08 |
20120282279 | Anti-Diabetic Compounds - The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions. | 2012-11-08 |
20120282280 | BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES - This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical 5 compositions containing said antibodies, and uses thereof. | 2012-11-08 |
20120282281 | Agents that Engage Antigen-Presenting Cells Through Dendritic Cell Asialoglycoprotein Receptor (DC-ASGPR) - The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells. | 2012-11-08 |
20120282282 | Methods for Decreasing Ocular Toxicity of Antibody Drug Conjugates - The invention relates to charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of using the same to reduce ocular toxicity associated with administration of antibody drug conjugates. | 2012-11-08 |
20120282283 | PRODUCTION OF CLOSED LINEAR DNA - An in vitro process for the production of closed linear deoxyribonucleic acid (DNA) comprises (a) contacting a DNA template comprising at least one protelomerase target sequence with at least one DNA polymerase in the presence of one or more primers under conditions promoting amplification of said template; and (b) contacting amplified DNA produced in (a) with at least one protelomerase under conditions promoting production of closed linear DNA. A kit provides components necessary in the process. | 2012-11-08 |
20120282284 | METHODS AND COMPOSITIONS FOR PRODUCING ANTIGENIC RESPONSES - The present inventions relates to methods of producing an antigenic response in which an antigen is contacted to an antigen-presenting cell, wherein the improvement comprises contacting the antigen-presenting cell with an A | 2012-11-08 |
20120282285 | MASP ISOFORMS AS INHIBITORS OF COMPLEMENT ACTIVATION - The present invention relates to novel ficolin-associated polypeptides, and polypeptides derived from these ficolin-associated polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases, as well as the use as biomarkers. The present invention further relates to anti-bodies recognising such novel ficolin-associated polypeptides, and polypeptides derived thereof, nucleic acid molecules encoding such polypeptides, vectors and host cells used in the production of the polypeptides. | 2012-11-08 |
20120282286 | PEPTIDE VACCINES FOR CANCERS EXPRESSING MPHOSPH1 OR DEPDC1 POLYPEPTIDES - The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPH1 and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines. | 2012-11-08 |
20120282287 | Novel Flavivirus Antigens - The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability to induce an immune response to flaviviruses. The polypeptides and polynucleotides of the invention are useful in methods of inducing immune response against flaviviruses, including dengue viruses. Compositions and methods for utilizing polynucleotides and polypeptides of the invention are also provided. | 2012-11-08 |
20120282288 | Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides - Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest. | 2012-11-08 |
20120282289 | STAPHYLOCOCCAL ANTIGENS - The present invention provides novel sequences encoding | 2012-11-08 |
20120282290 | Mycobacterial Vaccines - There is provided a fusion protein or a polynucleotide sequence encoding said fusion protein that comprises first and second domains, wherein the first domain of the fusion protein comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO: 1, or a fragment thereof comprising at least 20 consecutive amino acids thereof; and wherein the second domain of the fusion protein comprises a mycobacterial antigen or an antigenic fragment thereof. Also provided are corresponding therapeutic uses thereof for the protection of primates against mycobacterial infections. | 2012-11-08 |
20120282291 | VACCINE VECTORS AND METHODS OF ENHANCING IMMUNE RESPONSES - Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject. | 2012-11-08 |
20120282292 | METHODS AND COMPOSITIONS RELATED TO IMMUNOGENIC FIBRILS - Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant. | 2012-11-08 |
20120282293 | Multivalent Live Vector Vaccine against Clostridium difficile-Associated Disease - The invention relates to a multivalent | 2012-11-08 |
20120282294 | REFRIGERATOR-TEMPERATURE STABLE INFLUENZA VACCINE COMPOSITIONS - Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided. | 2012-11-08 |
20120282295 | PURIFICATION OF STAPHYLOCOCCUS AUREUS TYPE 5 AND TYPE 8 CAPSULAR SACCHARIDES - The invention provides a method for releasing capsular polysaccharide from | 2012-11-08 |
20120282296 | METHODS FOR IMPROVING THE DESIGN, BIOAVAILABILITY, AND EFFICACY OF DIRECTED SEQUENCE POLYMER COMPOSITIONS VIA SERUM PROTEIN-BASED DETECTION OF DIRECTED SEQUENCE POLYMER COMPOSITIONS - There exist in the art methods of detecting simple peptides. However, methods to determine the effective plasma concentration of directed sequence polymers (DSPs), are complicated because DSPs are complex mixtures of peptides, as opposed to individual peptides with a defined amino acid sequence. This application provides improved methods of detecting and assessing DSP compositions, methods for the detection and quantitation of DSP compositions, means to determine and enrich a subset of peptides in a DSP composition based on the subset's interactions with certain capture polypeptides, and methods for administering DSP compositions to a subject in need thereof, wherein the dosage regimen and quantity may be determined or evaluated based on the above-mentioned methods for detection and quantitation. | 2012-11-08 |
20120282297 | METHOD FOR TREATING CONSTIPATION - The invention relates to methods and compositions for the treatment of constipation. The method of the invention involves administration of a suppository containing chlorophyll, chlorophyllin copper complex or chlorophyllin. The suppository contains an outer layer to prevent spillage of chlorophyll or chlorophyllin prior or after administration. Other ingredients that may also be effective treatments may be included. This method may be useful as a new and safer treatment for constipation, including constipation-predominant IBS and other functional anorectal disorders. Chlorophyll, or chlorophyll copper complex and chlorophyllin in the suppository form may improve bowel activity by stimulation of secretion and motility, thus relieving symptoms of constipation. This is the first description of this unique method of delivering these safe, natural products to patients suffering from constipation. | 2012-11-08 |
20120282298 | CORTICOSTEROIDS FOR THE TREATMENT OF JOINT PAIN - Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production. | 2012-11-08 |
20120282299 | COATINGS COMPRISING BIS-(ALPHA-AMINO-DIOL-DIESTER) CONTAINING POLYESTERAMIDE - The present invention relates to a coating comprising at least one biodegradable polymer, wherein the polymer comprises at least one or a blend of a poly (ester amide) (PEA) having a chemical formula described by structural formula (II), wherein; R | 2012-11-08 |
20120282300 | PROTEIN BIOMATERIALS AND BIOCOACERVATES AND METHODS OF MAKING AND USING THEREOF - The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices. | 2012-11-08 |
20120282301 | POROUS CALCIUM PHOSPHATE BONE MATERIAL - Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided. | 2012-11-08 |
20120282302 | BIOMATERIAL COMPOSITE COMPOSITION AND METHOD OF USE - This invention relates to a process to facilitate osteochondral bone remodeling in a subject by inducing regeneration of this bone to a healthy, vascularized state capable of supporting the underlying hyaline cartilage of articular joints and spinal discs, both biomechanically and metabolically and to deliver a bioactive agent. This process involves the steps of: administering an effective amount of an injectable in situ curing biomaterial composite to a site. The biomaterial composite product is prepared by a process involving the steps: admixing an alginate solution with a nonporous aggregate of β-tricalcium phosphate, in a sufficient amount to initiate polymerization of the alginate solution, to form a hydrogel having from between 10 to 20 percent by volume of β-tricalcium phosphate. | 2012-11-08 |
20120282303 | PERCUTANEOUS ABSORPTION PREPARATION COMPRISING ANTI-DEMENTIA DRUG - The present invention relates to a percutaneous absorption preparation that is lower skin irritation and enables efficient transdermal administration of an anti-dementia drug. More specifically, the present invention relates to a percutaneous absorption preparation comprising an anti-dementia drug, a polymer compound having an amino group, a polyvalent carboxylate ester, a fatty acid alkyl ester, a styrenic polymer compound, and a tackifier resin. | 2012-11-08 |
20120282304 | MULTI-COATED LACTIC ACID BACTERIA AND PREPARING METHOD THEREOF - The present invention relates to multi-coated lactic acid bacteria coated with a multi-coating layer forming bacterial clusters and including protein, polysaccharide, and edible oil/fat component, and a preparing method thereof. The multi-coated lactic acid bacteria according to the present invention may achieve an improved acid resistance, a bile resistance, and an accelerated test stability, may have a low moisture content to be particularly stable against a moisture variation, and thus may be appropriately used to prepare various products including lactic acid bacteria. | 2012-11-08 |
20120282305 | BIOLOGICAL SURFACTANTS FOR CONNECTION TO SILICONE-BASED MATERIALS AND MODULATING LEVELS OF IMMUNOLOGICALLY ACTIVE PROTEINS - Biological surfactants connected to surfaces of silicone-based materials are provided. Compositions of electrolytes and a biological surfactant are also provided. Methods for increasing the surface wettability of a silicone-based material by contacting the silicone-based material with a biological surfactant, methods for increasing evaporation from a silicone-based material by contacting a surface of the silicone-based material with a biological surfactant, methods for increasing levels of interleukin-8 during inflammation by contacting a cell with a biological surfactant, and methods for decreasing expression of a biological surfactant by contacting a cell with an siRNA are further provided. | 2012-11-08 |
20120282306 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 2012-11-08 |
20120282307 | GASTRIC RETAINED GABAPENTIN DOSAGE FORM - A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form. | 2012-11-08 |
20120282308 | FILM CONTAINING ALGINATE MEMBRANE AND MANUFACTURING METHOD OF THE SAME - A film containing alginate membrane and a manufacturing method of the same are revealed. A film carrier is used to absorb liquid and is treated by two separate and continuous coating processes. At least one surface of the film carrier is coated with a layer of alginate solution containing a certain percent of sodium alginate or potassium alginate by weight and then is coated with a layer of salt water solution containing a certain percent of divalent metal ions. Then crosslinking occurs between the alginate in the alginate solution and the divalent metal ions in the salt solution on the surface of the film carrier or infiltrating into the film carrier so as to form a hydrogel complex membrane having a network structure. Thus the continuous and fast mass-production of the film is achieved. | 2012-11-08 |
20120282309 | Conditioner Compositions with Increased Deposition of Polyacrylate Microcapsules - A conditioner composition that increases the deposition and retention of benefit agent containing polyacrylate microcapsules onto hair. The conditioner composition is based on the combination of anionic charged polyacrylate microcapsules, deposition aids, conditioner agents, and a carrier. | 2012-11-08 |
20120282310 | PHOTOPROTECTIVE COMPOSITIONS AND FILMS, AND A PREPARATION METHOD - A photoprotective composition, in particular a cosmetic composition, that includes particles of photonic material having a polymeric multilayer interference structure, where at least two layers of the structure contain an amphiphilic polymer. | 2012-11-08 |
20120282311 | PIGMENTS WITH IMPROVED SPARKLING EFFECT - The present invention relates to pigments with improved and adjustable sparkling effect comprising A) a plate-like substrate of perlite coated with (a) dielectric material, and/or metal; and B) a plate-like substrate of mica, coated with (a) dielectric material, and/or a metal; and a process for their production and their use in paints, ink jet printing, for dyeing textiles, for pigmenting coatings (paints), printing inks, plastics, cosmetics, glazes for ceramics and glass. The pigments show an improved sparkle effect; in particular an attractive high sparkle intensity. | 2012-11-08 |
20120282312 | ACTIVE INGREDIENT DELIVERY SYSTEM - A spray-chilled particulate delivery system that has a crystalline matrix structure and includes a volatile hydrophobic active ingredient and a carrier material of erythritol, mannitol and mixtures thereof 75% or more of the carrier material, relative to the total weight of the carrier material, is in crystalline form. The system is prepared by a process that includes the steps of forming a melt of the carrier material, incorporating a volatile hydrophobic active ingredient into the melt, forming a melt-mixture comprising an emulsion, dispersion or suspension of the volatile hydrophobic active ingredient in the melt, forming discrete particles of the melt mixture, and cooling the discrete particles. | 2012-11-08 |
20120282313 | HIGH CLEANING AND LOW ABRASION SILICA MATERIALS TO MODULATE ENTRAPMENT AND RELEASE OF HYDROPHOBIC ACTIVES IN DENTAL FORMULATIONS - Described herein are compositions which modulate entrapment and release of flavorants and other actives in dental formulations. | 2012-11-08 |
20120282314 | DERMATOLOGICAL/COSMETIC SKIN DEPIGMENTING COMPOSITIONS - Depigmenting compositions having improved effectiveness in the dermatological or cosmetic treatment of pigmentation contain, in a physiologically acceptable medium, at least one compound selected from among rucinol and salts thereof, and at least one retinoid; such compositions are also useful in the prevention and/or dermatological treatment of skin hyperpigmentation, and also for the cosmetic treatment of photoinduced or chronological aging of the skin or of the skin appendages. | 2012-11-08 |
20120282315 | COMPOSITIONS AND METHODS FOR MAKING ANIMAL ATTRACTANT AND METHODS AND SYSTEMS FOR DEPLOYING ANIMAL ATTRACTANT - The present invention provides a method for making a storable and deployable game attractant and the resulting composition. Ground animal bone creates a base bone powder that is processed into a storable and deployable attractant product that may be transported to a location and deployed for attracting game animals. The attractant product may be combined with at least one of the group consisting of a talc-based substance, a gland powder, and any other animal attractant. The attractant product may be applied to one of a group consisting of wicks, scent pads, and wafers. The attractant product may include a cover scent adapted to cover the scent of a human and/or a burn promoting substance to promote deployment of the attractant product. The attractant product may be processed into a form from the group consisting of a solid, a powder, a liquid, a gel, and a paste. | 2012-11-08 |
20120282316 | METHOD OF MAKING INORGANIC POROUS PARTICLES - Sol-gel inorganic porous particles are composed of an inorganic compound that provides an inorganic solid phase including an external particle surface. They also have a first set of pores wherein the pores have an average diameter of less than 100 nm and a second set of pores wherein the pores have an average diameter of at least 100 nm, which second set of pores contains stabilizing organic microgel particles. These inorganic porous particles are prepared using a first oil phase comprising a first water-immiscible aprotic solvent having a dielectric constant of less than 10 and having dissolved therein organic microgel particles. An aqueous phase comprising a polar solvent, an inorganic gel precursor, a catalyst, and a dispersing surfactant is neutralized to initiate condensation of the inorganic gel precursor. An oil-in-water emulsion is then formed with the organic microgel particles in the first oil phase, which is dispersed as first oil phase droplets in the aqueous phase. A second oil phase is combined with the oil-in-water emulsion with the second oil phase to form an oil-in-water-in-oil emulsion comprising the first oil phase droplets in the aqueous phase. | 2012-11-08 |
20120282317 | Medicated popsicle system - A system for providing medication in an edible frozen form consists of a popsicle mold, a popsicle holder with a core stick, handle and drip guard, and a liquid mixture containing sweeteners, edible colorants, and flavorings which is individually mixed with medication for each popsicle in order to add a custom flavoring to mask the taste of the medicine and encourage consumption by children. The system also includes a mixing implement and storage for the mixing implement incorporated into the popsicle mold, writable and erasable areas on the mold where information particularly relevant to the medicine type, dosage and administration schedule can be written and then changed as needed, an erasable writing implement, and storage for the writing implement incorporated into the popsicle mold. | 2012-11-08 |
20120282318 | SHEET FOR CORNEAL TRANSPLANTS - The present invention relates to a sheet for corneal transplants comprising corneal endothelial cells on a gelatin hydrogel, which is obtainable by seeding and culturing corneal endothelial cells on a gelatin hydrogel coated with collagen. The sheet of the present invention is extremely useful as a sheet for corneal transplants not only for its biocompatibility and biodegradability, but also for its high transparency. | 2012-11-08 |
20120282319 | LOTIONED WIPE PRODUCT TO REDUCE ADHESION OF SOILS OR EXUDATES TO THE SKIN - An anti-stick agent that may be incorporated into an aqueous medium to assist in the prevention of soils and bodily exudates adhering to the skin. A substrate may be utilized to assist in delivering the anti-stick agent to the skin. | 2012-11-08 |
20120282320 | Hemostatic dressing - The present invention relates to the preparation of a hemostatic dressing in the form of a powder that is particularly applicable for stemming severe bleeding and for incorporation of the powder into dressings that can stabilize the site of tissue injury, and simultaneously act as an antimicrobial agent. | 2012-11-08 |
20120282321 | Wound Dressings Containing Complexes of Transition Metals and Alginate for Elastase-Sequestering - Transition metal (e.g., silver and copper) derivatized phosphorylated polysaccharides (cellulose, starch, gauze) provide antimicrobial and elastase sequestration properties to wound dressings, and the wound dressing have enhanced water sorption and elastase sequestration when used with alginates. Wound dressings with alginates (e.g., silver alginate, crosslinked alginates, etc.) provide enhanced wound fluid absorption as well as elastase sequestration. | 2012-11-08 |
20120282322 | COCHLEATE COMPOSITIONS DIRECTED AGAINST EXPRESSION OF PROTEINS - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 2012-11-08 |
20120282323 | Dry Liposomal PVP-iodine Compositions - The present invention is directed to a storage stable package of a iodophor containing particulate pharmaceutically acceptable carrier compositions. The invention is particularly directed to a storage stable package of a PVP-iodine liposome compositions. The packaging material is generally plastic, paper or cardboard. | 2012-11-08 |
20120282324 | Methods for Promoting the Revascularization and Reenervation of CNS Lesions - The present invention provides methods of promoting the revascularization and/or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering to the spinal cord injury site a vehicle comprising a neurotrophic factor and/or anti-inflammatory agent. Also provided are methods of treating a spinal cord injury by topically administering or delivering a hydrogel to the injury site. | 2012-11-08 |
20120282325 | LIPOSOME OF IRINOTECAN OR ITS HYDROCHLORIDE AND PREPARATION METHOD THEREOF - A liposome of irinotecan or irinotecan hydrochloride and its preparation method are disclosed. The liposome contains irinotecan or irinotecan hydrochloride, neutral phospholipid and cholesterol, wherein the weight ratio of the cholesterol to the neutral phospholipid is 1:3 to 1:5. The liposome is prepared by an ion gradient method. | 2012-11-08 |
20120282326 | COMPOSITIONS AND METHODS RELATED TO MIRNA IN DIABETIC CONDITIONS - The present invention relates to methods of treating a disorder associated with glucose mediated cell damage in a subject comprising administering to the subject an agent that modulates the expression of one or more miRNAs in a damaged cell or cells of the subject. The present invention also relates to compositions for treating a disorder associated with glucose mediated cell damage comprising an agent that modulates the expression of one or more miRNAs in a damaged cell or cells. The invention also relates to methods of diagnosing a disorder associated with glucose mediated cell damage in a subject, including diagnosis of diabetic retinopathy. | 2012-11-08 |
20120282327 | PHOSPHATE-CONTAINING NANOPARTICLE DELIVERY VEHICLE - A phosphate-containing nanoparticle delivery vehicle includes nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release. | 2012-11-08 |
20120282328 | DUAL ACTION, INHALED FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE - Methods for formulating immediate and sustained release anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described. | 2012-11-08 |
20120282329 | MUC1 Based Glycolipopeptide Vaccine with Adjuvant - Provided herein are liposomal glycolipopeptidic vaccine formulations comprising an adjuvant and an immunogen for immunotherapy and/or treatment of cancer. | 2012-11-08 |
20120282330 | CHINESE HERBAL COMPOSITION FOR THE TREATMENT OF MACULAR DEGENERATION AND THE PROCESS FOR MANUFACTURING THE SAME - The present invention provides a Chinese herb composition for the treatment of macular degeneration and its preparation method. The composition comprises Salviae miltiorrhizae, Chuanxiong rhizoma, Lycii fructus, Chrysanthemi flos, Schisandrae chinensis fructus, Imperatae rhizoma, and Scutellariae radix, where the number of units by weight are: 0.8-3.0 units of Salviae miltiorrhizae, 0.3-2.0 units of Chuanxiong rhizoma, 0.6-2.4 units of Lycii fructus, 0.5-2.0 units of Chrysanthemi flos, 0.2-1.2 units of Schisandrae chinensis fructus, 0.9-6.0 units of Imperatae rhizoma, and 0.5-2.0 units of Scutellariae radix. The preparation method includes taking concentrated powder of each ingredient according to the number of units prescribed and mixing them together. The Chinese herb composition, conveniently delivered orally or parenterally, has been clinically proven to be safe and effective for all types of macular degeneration regardless of wet or dry forms. | 2012-11-08 |
20120282331 | MAMMALIAN METABOLITES OF STEROIDS - Described herein, in certain embodiments, are steroidal derivatives, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat androgen receptor mediated diseases or conditions. | 2012-11-08 |
20120282332 | COMPOSITION AND METHOD THEREOF - The present disclosure relates to a composition comprising Trigoneoside Ib and Vicenin-1 for treatment and management of Goodpasture's disease, Glomerulonephritis, Rheumatoid Arthritis, Systemic Lupus Erythematosus and Idiopathic Thrombocytopenia Purpura. The present disclosure also relates to a method of obtaining the said composition from | 2012-11-08 |
20120282333 | DELAYED RELEASE PHARMACEUTICAL COMPOSITION OF MESALAMINE - The invention relates to a delayed release pharmaceutical composition of mesalamine comprising: a) granules comprising mesalamine or pharmaceutically acceptable salts thereof and a hydrophilic polymer; b) extragranular excipients; wherein the pharmaceutical composition is further coated with a single layer of polymer. | 2012-11-08 |
20120282334 | PROCESS FOR PREPARING AJOENE FROM GARLIC - Disclosed is a method for preparing ajoene including: (a) obtaining garlic pulp or garlic extract from garlic; (b) mixing the garlic pulp or garlic extract with animal lipid to form a reaction mixture; and (c) heating the reaction mixture to obtain ajoene. The ajoene prepared according to the present disclosure may be encapsulated with gelatin. According to the present disclosure, ajoene can be prepared with a yield 2 times or more than that of the existing methods. Thus, ajoene can be provided as active ingredient for foods and medicines more cost-effectively. Also, the production protocol according to the present disclosure is suitable for large-scale production of ajoene. | 2012-11-08 |
20120282335 | RAPIDLY DISPERSING GRANULES, ORALLY DISINTEGRATING TABLETS AND METHODS - This invention relates to rapidly dispersing microgranules comprising at least one sugar alcohol or saccharide, at least one super disintegrant, and a pharmaceutically acceptable additive with multi-functionality (e.g., starch acting as a binder, disintegrant, diluent/filler, glidant, etc) at a low level, which can be formed by not only eliminating a wet milling step but also avoiding an extensive dry milling step. Furthermore, such rapidly dispersing microgranules could also comprise a pharmaceutically active agent thereby providing for a pharmaceutical composition, or the rapidly dispersing microgranules thus produced are suitable for blending with a pharmaceutically active agent that is optionally taste-masked and/or controlled release coated microparticles to also provide for a pharmaceutical composition and the invention is also directed to a method for manufacturing such rapidly dispersing microgranules in a high useable yield, as well as orally disintegrating tablets comprising such rapidly dispersing microgranules. The rapidly dispersing microgranules are also free flowing. | 2012-11-08 |
20120282336 | BILAYER TABLET FORMULATIONS - The present invention relates to bilayer tablet formulations comprising metformin extended release (XR) or reduced mass metformin XR formulation as the first layer, an SGLT2 inhibitor formulation as the second layer, and optionally a film coating. The present invention provides methods of preparing the bilayer tablet formulations and methods of treating diseases or disorders associated with SGLT2 activity employing the bilayer tablet formulations. | 2012-11-08 |
20120282337 | Modified Release Formulation - The invention is directed to the use of an extended release tablet formulation for pramipexole. | 2012-11-08 |
20120282338 | Extended Release Formulation - The invention is directed to an extended release formulation comprising pramipexole or a pharmaceutically acceptable salt thereof. | 2012-11-08 |
20120282339 | ELECTROLYTE PURGATIVE - The invention relates to compositions for use in purgatives, to purgatives comprising such compositions, and to methods for inducing purgation of the colon. The composition may comprise at least one water-soluble sodium salt; at least one water-soluble minimally degradable sugar in an amount, by weight, of from about 1 to about 3 times the weight of sodium ions in said composition; at least one water-soluble potassium salt in an amount, by weight, of from about 0.05 to about 1 time the weight of said sodium salt in said composition; and at least one water-soluble magnesium salt, wherein the weight of magnesium ions in said composition is from 0.1 to about 10 times the weight of sodium ions in said composition. | 2012-11-08 |
20120282340 | DRUG DELIVERY SYSTEM - The present invention relates to drug delivery systems in the form of thin water-soluble films (wafers), which contain an Estrogen Receptor beta (ER-β) selective agonist. The wafers of the present invention are suitable for treating, alleviating or preventing a physical condition in a female mammal caused by insufficient endogenous levels of estrogen. | 2012-11-08 |
20120282341 | Lipid Formulated Compositions And Methods For Inhibiting Expression Of Eg5 And VEGF Genes - This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a SNALP formulation, methods of using the compositions to inhibit the expression of the Eg5/KSP and VEGF, and methods of using the compositions to treat pathological processes mediated by Eg5/KSP and VEGF expression, such as cancer. | 2012-11-08 |
20120282342 | METHOD FOR PREPARING POLYSACCHARIDE NANOCOMPOSITE PARTICLES AND USES OF THE SAME - A method for preparing polysaccharide nanocomposite particles is provided. The method comprises providing a first solution comprising an active component and a polysaccharide; adding a cross-linking agent to the first solution to provide a second solution; and allowing the second solution to conduct the reaction to form polysaccharide nanocomposite particles. The polysaccharide nanocomposite particles thus prepared show good coating ratio and enhanced applicability. Also provided is a method for inducing cancer cell apoptosis in a subject, comprising administrating to the subject an effective amount of the polysaccharide nanocomposite particles. | 2012-11-08 |
20120282343 | COMPOSITIONS FOR ORAL GENE THERAPY AND METHODS OF USING SAME - The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy. | 2012-11-08 |
20120282344 | FORMULATION FOR THE BIOLOGICAL CONTROL OF INSECT-PESTS - A formulation for the biological control of pests comprises a cohort of infective juvenile insect-parasitic nematodes from at least three species, wherein at least two of the species are of a first genus, and at least one of the species is from a second genus, and the species number from the first genus is greater than the species number from the second genus. The cohort of nematodes consists essentially of two species from the first genus and one species from the second genus and comprises at least one ambusher foraging species of nematode from a first genera and at least two cruiser foraging species of nematode from a different genera, or at least two ambusher foraging species of nematode from the same genera and at least one cruiser foraging species of nematode from a different genera. The first and second genus are selected from the group comprising: Steinernematidae and Heterorhapditidae. | 2012-11-08 |
20120282345 | PESTICIDE COMPOSITION COMPRISING PROPAMOCARB-HYDROCHLORIDE AND AN INSECTICIDE ACTIVE SUBSTANCE - The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on propamocarb-HCl, an insecticide active substance and optionally a further fungicide active substance. | 2012-11-08 |
20120282346 | BRIMONIDINE COMPOSITIONS FOR TREATING ERYTHEMA - The present invention is directed to a pharmaceutical composition including brimonidine tartrate in an amount from about 0.17 percent by weight to about 0.19 percent by weight in a pharmaceutically acceptable carrier such as a gel or cream. The invention also relates to a method of treating erythema in a patient with rosacea by administering the composition of the invention to the site of erythema on the skin of the patient. | 2012-11-08 |
20120282347 | PREPARATION OF SILVER ION - Disclosed is a process for preparing silver ions (Ag | 2012-11-08 |
20120282348 | Antimicrobial Silver Hydrogel Composition For The Treatment of Burns And Wounds - An antimicrobial therapeutic hydrogel composition comprises a pharmaceutical and/or medical grade silver salt, and an Aloe vera gel or extract. The composition could also include stabilizing agents, a non-ionic surfactant, polyol, and hydrophilic hygroscopic polymers. The resulting product has potent antimicrobial activity against bacteria, protozoa, fungi and viruses. The antimicrobial therapeutic composition can serve as a treatment for burns and as a wound/lesion dressing that either donates or receives moisture to provide a physiologic environment for accelerated wound healing and the relief of pain. | 2012-11-08 |
20120282349 | PLANT DISEASE CONTROL COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASE BY APPLYING THE SAME - This is to provide a plant disease control composition having a broad spectrum against various plant pathogens, and shows excellent controlling effects (synergistic controlling effects) which cannot be expected from a single component alone. | 2012-11-08 |
20120282350 | PERFORMANCE ENHANCING COMPOSITIONS AND METHODS OF USE - The present invention relates to composition containing sialic acids or precursors, and their use to improve performance-related and social parameters in mammals, particularly humans and horses. The daily dosage is preferably selected from the group consisting of 1 microgram to 100 mg/day, 100 microgram to 20 mg/day, and 200 microgram to 10 mg/day. | 2012-11-08 |
20120282352 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF - The present invention provides, among other things, compositions and methods suitable for the treatment of hyperphosphatemia based on phosphate-binding magnesium salts. In some embodiments, the present invention provides compositions and methods suitable for the treatment of hyperphosphatemia based on the combination of phosphate-binding magnesium and calcium salts. | 2012-11-08 |
20120282353 | METHODS, COMPOSITIONS AND ARTICLES OF MANUFACTURE FOR HIF MODULATING COMPOUNDS - The present invention generally relates to the modulation of hypoxia-inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis. | 2012-11-08 |
20120282354 | COMPOSITION FOR PREVENTING OR TREATING DISEASES CAUSED BY INFLUENZA VIRUSES - The present invention relates to herbal medicine extracts useful in the prevention or treatment of diseases caused by influenza viruses, and to a pharmaceutical composition or health food comprising the extracts. The herbal medicine extracts of the present invention are derived from natural materials, and are safe for the human body, and can be used in preventing and treating and in relieving symptoms of diseases caused by various types of influenza viruses. | 2012-11-08 |
20120282355 | MUD MASK WITH REAL TEA LEAF AND METHOD FOR MAKING THE SAME - A mud mask with real green tea leaves is described. The mud mask is made by separating a real green tea leaf batch into a first sub-batch, a second sub-batch, and a third sub-batch. The first sub-batch is ground into a fine powder, while the second sub-batch remains as whole leaves and the third sub-batch is chopped into partially chopped leaves. The fine powder and whole leaves are added to hot water for a period of time to form a brewed tea. Thereafter, the partially chopped leaves and mud components are added to the brewed tea to form a mud solution, which is mixed to form the mud product. The mud product is packaged and allowed to marinate, which allows the leaves to begin releasing their nutrients and antioxidants into the mud formula, after which the mud mask includes atypical and unusually high levels of nutrients, antioxidants and caffeine. | 2012-11-08 |
20120282356 | COMPOSITIONS FOR PREVENTION AGAINST SPOILAGE BY MOULDS AND YEASTS AND USES AND PRODUCTS RELATED THERETO - The invention is related to compositions for prevention against spoilage by moulds and yeasts comprising, as the only antimycotic agents, at least one compound selected from organic acids selected from the group consisting of caprylic acid, cinnamic acid, propionic acid, butyric acid, lactic acid, tartaric acid and fumaric acid, and salts thereof, and at least one compound selected from plant of fruit extracts, the oily phases of plant or fruit extracts, and monosubstances derived from such extracts or oily phases thereof. The invention is furthermore related to the use of such or similar compositions for protection of food or feed products from growth of moulds and yeasts as well as to food or feed products containing such compositions. | 2012-11-08 |
20120282357 | METHOD OF ENHANCING SKIN BARRIER FUNCTION - A method for adjusting calcium ion in epidermis is described. The method involves applying a material for enhancing skin barrier function to the skin of a subject. Appropriate materials include | 2012-11-08 |
20120282358 | ORAL ADMINISTRATION COMPOSITION - A composition which has high safety and is excellent in the effect of reducing body fat, such as visceral fat, subcutaneous fat and the like, and neutral fat, and a food, a pharmaceutical and a feed comprising the same, are provided. An oral administration composition having a body fat reducing action and/or a neutral fat reducing action, which is a composition comprising a carotenoid and a sphingolipid or a carotenoid and a flavonoid and/or a derivative thereof, preferably a composition comprising a cryptoxanthin and a sphingolipid or a cryptoxanthin and a flavonoid and/or a derivative thereof, wherein the cryptoxanthin and/or the sphingolipid and/or the flavonoid are derived from a | 2012-11-08 |
20120282359 | Compositions, Kits, and Methods for the Treatment of Conditions Associated with Elevated Cholesterol Levels - Disclosed herein are methods of treating a condition associated with elevated cholesterol levels are provided, comprising administering to a mammal in need of such treatment a safe and effective amount of a cholesterol biosynthesis inhibitor and a soluble fiber. Further disclosed herein are kits comprising a first composition comprising a cholesterol biosynthesis inhibitor selected from the group consisting of HMG CoA reductase inhibitors, HMG CoA synthase inhibitors, and mixtures thereof; and a second composition comprising a soluble fiber. Even further described are compositions comprising a cholesterol biosynthesis inhibitor selected from the group consisting of HMG CoA reductase inhibitors, HMG CoA synthase inhibitors, and mixtures thereof; and a soluble fiber. | 2012-11-08 |
20120282360 | HERBAL PREPARATION TO RELIEVE INFLAMMATION AND SMOOTH MUSCLE CONTRACTION - An herbal preparation comprised of sage, thyme and cumin is found to relieve the symptoms of inflammation and smooth muscle contraction. The preparation preferably comprises sage, thyme and cumin in the proportions 0.50, 0.43 and 0.07 respectively. The symptoms of menstrual cramps and asthma are relieved by administration of the preparation. | 2012-11-08 |
20120282361 | METHOD OF GRANULATION WITH A FLUIDIZED BED GRANULATOR - A granulator, having a granulation unit having a bottom floor with a perforated plate as its bottom part; an upper air-supplying pipe for supplying a fluidizing air to the bottom of the granulation unit; a lower air-supplying pipe; air-spouting pipes, each of which is branched from the lower air-supplying pipe, and has an opening in the bottom of the perforated plate, for jetting the air into the granulation unit; and spray nozzles for spraying a granulation raw material liquid, which each are provided in the center of an air outlet of the air-spouting pipe, or having: the bottom; the air-supplying pipe; and spray nozzles for spraying a granulation raw material liquid each of which are provided in an opening in the bottom of the perforated plate, and use a high-pressure atomizing air as an auxiliary gas, with the spray nozzles being provided in a triangular arrangement. | 2012-11-08 |
20120282362 | POROUS FILM MANUFACTURING METHOD AND SUCCESSIVE BIAXIAL STRETCHING APPARATUS FOR MANUFACTURING POROUS FILM - Provided is a method for manufacturing a high-quality porous film. Here, while the porous film is being manufactured through forming micropores by stretching, a raw film is prevented from slipping on the surfaces of the respective rolls as much as possible even though the raw film includes oil or liquid paraffin as a solvent. The method is for manufacturing a porous film through forming micropores by successive biaxial stretching. A tensile force applied to the raw film F transferring from the longitudinal stretching machine ( | 2012-11-08 |
20120282363 | MOLDING BENCH FOR CURVING MIRRORS - Molding bench for curving mirrors comprising a sheet ( | 2012-11-08 |
20120282364 | Method and Apparatus For Forming A Batt of Particulate Material for Use as A Component in an Absorbent Core Assembly - A method and apparatus for forming a batt of particulate material which may be used in an absorbent article. The apparatus may include a vacuum zone, an air impermeable fence zone adjacent to the vacuum zone, and an air permeable fence zone adjacent to the vacuum zone. The air permeable fence zone may comprise an ambient air entry conduit in communication with an ambient air exit port. The method may include providing a laydown drum and a first web of material, positioning the first web of material substantially adjacent to the laydown drum, generating a vacuum through the laydown drum, depositing particulate matter onto the first web of material, and rotating the laydown drum. | 2012-11-08 |
20120282365 | BELLING MACHINE FOR FORMING SOCKETS ON THE ENDS OF PIPES MADE OF THERMOPLASTIC MATERIAL AND METHOD OF FORMING A SOCKET AT THE END OF A PIPE MADE OF THERMOPLASTIC MATERIAL - In a belling machine and in a method of forming a socket at the heated end of a pipe, an end of a pipe made of thermoplastic material on which a socket is to be formed is heated until it is in a deformable state, inserted in a forming chamber and formed into a socket shape. Process air, taken from a compressed air source, is conveyed into an evaporator of a refrigerating machine using a refrigerant recirculating in a closed circuit and passes through the evaporator, resulting in transfer of heat from the process air to the refrigerant inside the evaporator. The process air is then conveyed to the forming chamber through an inlet, at least to cool the material of the end of the pipe at least by means of a process air flow inside the forming chamber. | 2012-11-08 |
20120282366 | MOLD FOR FOOTWEAR BOTTOMS - A mold devised for molding of footwear bottoms, composed of overlapping layers made with expandible reticulable polyolefin material, as well as for molding of other manufactures with monolithic structure composed of overlapping layers of expandible reticulable polyolefin materials. | 2012-11-08 |