45th week of 2017 patent applcation highlights part 11 |
Patent application number | Title | Published |
20170319747 | THREE-DIMENSIONAL CULTURE METHOD USING BIODEGRADABLE POLYMER AND CULTURE SUBSTRATE ENABLING CELL TRANSPLANTATION - The present invention provides a cell culture substrate containing a nanofiber composed of a biodegradable polymer on a support composed of a biodegradable polymer. It also provides a method of culturing cells, which includes seeding cells on the substrate, and stationary culture of the cells. Furthermore, the present invention provides an agent for cell transplantation therapy, which contains the substrate and cells cultured on the substrate. | 2017-11-09 |
20170319748 | METHOD FOR MANUFACTURING CILIARY MARGIN STEM CELLS - The invention provides a method for producing a ciliary marginal zone stem cell induced to differentiate from a pluripotent stem cell, including either the following step (1) or step (2), or both of these steps: (1) a step of floating culturing cells obtained from a cell aggregate containing a ciliary marginal zone-like structure induced to differentiate from pluripotent stem cells, thereby obtaining a retinosphere; and (2) a step of collecting stage specific embryonic antigen-1 positive cells from cells obtained from a cell aggregate containing a ciliary marginal zone-like structure induced to differentiate from pluripotent stem cells. | 2017-11-09 |
20170319749 | BIORESORBABLE-MAGNESIUM COMPOSITE - The invention relates to biocomposites comprising a polymeric matrix and a magnesium filler such as a water soluble magnesium salt. The use of elemental magnesium or magnesium alloy in the biocomposite is minimized and preferably avoided. The magnesium biocomposites can be used as bone implants. | 2017-11-09 |
20170319750 | COMPOSITE MATRICES DESIGNED FOR ENHANCED BONE REPAIR - Osteoconductive synthetic bone grafts are provided in which porous ceramic granules are embedded in a biocompatible matrix material. The grafts, which may also include one or more of a coating, a reinforcing bio-absorbable mesh, and an osteoinductive protein or peptide, are generally porous and may incorporate fenestrations. | 2017-11-09 |
20170319751 | Multiphase Gel - Disclosed are hydrogels polymerized with or around a solid biofunctional moiety, biodegradable or permanent, designed to be implantable in a mammalian body, intended to block or mitigate the formation of tissue adhesions, and intended to aid in functional healing. The hydrogels of the present invention are characterized by comprising multiphasic structural elements: a) at least one gel phase, b) at least one solid phase, c) optional polymeric chains connecting gel and solid phases, d) optional shape designs that provide for an interpenetrating geometry between gels and solids, e) optional shape designs that enhance a tissue-hydrogel interface, and f) optional shape designs that provide a biofunctional aspect. The hydrophobicity of the various phases is chosen to reduce tissue adhesion and enhance tissue healing. The morphology of the polymers comprising the gel phase is typically of high molecular weight and has morphology that encourages entanglement. Useful polymeric structures include branching chains, comb or brush, and dendritic morphologies. | 2017-11-09 |
20170319752 | FREE-STANDING BIODEGRADABLE PATCH - Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents. | 2017-11-09 |
20170319753 | HPPE MEMBER AND METHOD OF MAKING A HPPE MEMBER - The invention concerns a high performance polyethylene (HPPE) member comprising at least 5 wt-% of a radiopaque component, the HPPE member is biocompatible and the radiopaque component is a particulate at least partially arranged inside a HPPE filament of the HPPE member. Furthermore, the radiopaque component has a particle size of at most 1 μm, preferably the radiopaque component has a particle size of at most 0.5 μm. The invention also concerns a method of making the HPPE member and various medical devices and repair products comprising the HPPE member. | 2017-11-09 |
20170319754 | HEMOSTATIC DEVICES AND METHODS OF USE - An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a first component having a first substrate and a second component having a second substrate. The second component is positioned within the first component. One of the first and second substrates includes a hemostatic agent and the other of the first and second substrates includes an active pharmaceutical ingredient. Kits, systems and methods are disclosed. | 2017-11-09 |
20170319755 | HEMOSTATIC DEVICES AND METHODS OF USE - An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate formed from a first material and a second material. At least one of the first and second materials includes a hemostatic agent. Kits, systems and methods are disclosed. | 2017-11-09 |
20170319756 | HEMOSTATIC DEVICES AND METHODS OF USE - An anchorage device is provided that is configured to surround an implantable medical device. The anchorage device includes a substrate having a hemostatic agent and an active pharmaceutical ingredient selectively positioned on the substrate. Kits, systems and methods are disclosed. | 2017-11-09 |
20170319757 | Catheter Locking Solution Having Antimicrobial and Anticoagulation Properties - The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine. | 2017-11-09 |
20170319758 | PORTABLE PUMP FOR NEGATIVE PRESSURE WOUND THERAPY - A portable pump is provided for negative pressure wound therapy for drawing a vacuum from a wound site via a tube. The pump includes an inlet configured to attach the tube from the wound site; a canister in fluid communication with the inlet for collecting fluids drained from the wound site; and a manually-actuated pump mechanism for creating the vacuum. The pump mechanism includes a vacuum chamber in fluid communication with the canister; a piston disposed in the vacuum chamber; and a pump handle coupled to the piston to move the piston in the vacuum chamber between first and second positions to create the vacuum. The pump handle moving between a retracted position and an extended position. The piston is in the first position when said pump handle is in the retracted position and is in the second position when said pump handle is in the extended position. | 2017-11-09 |
20170319759 | SUCTION DEVICE - An embodiment includes a suction device handle for use with a vacuum supply conduit to suction a fluid or tissue, the handle comprising: a hand-grippable body defining a chamber; the hand-grippable body comprising a distal end configured to support a suction tip; the suction tip including a distal end of a vacuum supply conduit extending within an outer cannula, the vacuum supply conduit being offset from a distal end of the outer cannula by a predetermined distance; wherein the distal end of the hand grippable body is connected to a proximal end of the outer cannula and the chamber is connected in fluid communication with the suction pressure or vacuum generated at the distal end of the vacuum supply conduit. Additional embodiments are described herein. | 2017-11-09 |
20170319760 | SKIN TREATMENT USING VARIABLE RF - A skin treatment device used for cellulite treatment, skin tightening or body contouring which combines negative pressure treatment and RF treatment, where the RF treatment uses variable frequencies during a treatment cycle. | 2017-11-09 |
20170319761 | SYSTEMS AND METHODS FOR DELIVERING FLUID TO A WOUND THERAPY DRESSING - Systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure sensor measures the pressure at the wound therapy dressing and restricts fluid flow to the wound therapy dressing when a predetermined pressure is achieve. | 2017-11-09 |
20170319762 | WOUND CONNECTION PAD WITH PNEUMATIC CONNECTION CONFIRMATION ABILITY - A system, apparatus, and method for treating a tissue site with reduced pressure includes a connector having a connector body. The connector body includes a cavity and a cavity aperture. The connector also includes a conduit port fluidly coupling a conduit to the cavity. The connector further includes a base adjacent the cavity aperture that is configured to be positioned adjacent a drape. The cavity is configured to be fluidly coupled to a manifold through an aperture of the drape. The connector also includes a sensing probe having a proximal end configured to be fluidly coupled to the conduit and a distal end extending to the cavity aperture. The distal end is configured to be positioned adjacent to and in fluid communication with a manifold. | 2017-11-09 |
20170319763 | Systems And Methods For Treating A Tissue Site With Reduced Pressure Involving A Reduced-Pressure Interface Having A Multi-Lumen Conduit For Contacting A Manifold - Systems and methods for a reduced-pressure interface for connecting a multi-lumen conduit to a distribution manifold. The interface includes a housing having a flange portion and a cavity wall portion. The cavity wall portion forms a cavity having a tissue-facing cavity opening. The interface further includes an attachment device, a conduit port, and a multi-lumen conduit. The attachment device is coupled to a tissue-facing side of the flange portion for coupling the housing to a sealing member. The conduit includes a distal end and a proximal whereby the distal end extends through a conduit aperture and past the cavity wall portion into the cavity. The conduit further includes a primary lumen and a plurality of sensing lumens. The primary lumen and the plurality of sensing lumens extend from the proximal end of the conduit to the distal end. The conduit is adapted to contact the distribution manifold. | 2017-11-09 |
20170319764 | REDUCED ROTATIONAL MASS MOTOR ASSEMBLY FOR CATHETER PUMP - A catheter pump is disclosed. The catheter pump can include an impeller and a catheter body having a lumen in which waste fluid flows proximally therethrough during operation of the catheter pump. The catheter pump can also include a drive shaft disposed inside the catheter body. A motor assembly can include a chamber. The motor assembly can include a rotor disposed in the at least a portion of the chamber, the rotor mechanically coupled with a proximal portion of the drive shaft such that rotation of the rotor causes the drive shaft to rotate, the rotor including a longitudinal rotor lumen therethrough. The motor assembly can also comprise a stator assembly disposed about the rotor. During operation of the catheter pump, the waste fluid flows from the lumen into the chamber such that at least a portion of the waste fluid flows proximally through the longitudinal rotor lumen. | 2017-11-09 |
20170319765 | BLOOD TREATMENT SYSTEMS AND METHODS - Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands. | 2017-11-09 |
20170319766 | CUSTOMIZED DIALYSATE SOLUTION USING SPIKES - Systems and methods of generating a customized dialysate solution are provided. The system and methods use stock concentrates, with the addition of spikes to generate a customized dialysate solution based on the needs of the patient. | 2017-11-09 |
20170319767 | ELASTIC PROTECTION TUBE FOR A HOLLOW FIBER BLOOD PROCESSING APPARATUS - A blood processing apparatus includes a housing, a shell, a fiber bundle, and an elastic tube. The housing has a blood inlet and a blood outlet and the shell is situated in the housing and configured to receive blood through the blood inlet. The shell includes a surface and one or more apertures extending through the surface to permit the blood to flow to an exterior of the shell. The fiber bundle includes gas exchanger hollow fibers situated about the shell such that gas flows through and the blood flows across the gas exchanger hollow fibers. The elastic tube includes a fiber web situated about the fiber bundle and configured to elastically constrain and protect the gas exchanger hollow fibers during the insertion into the housing. The fiber web has a pore size that permits the blood to flow across the fiber web without filtering micro-emboli from the blood. | 2017-11-09 |
20170319768 | SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION USING WATER ACCUMULATOR AND DISPOSABLE SET - A peritoneal dialysis system includes a water purifier, a cycler, and a disposable set operable with the cycler. The disposable set includes a pumping cassette including a water inlet port, a heater/mixing container in fluid communication with the pumping cassette, a water accumulator, a first water line segment, and a second water line segment. The first water line segment is in fluid communication with the water inlet port and the water accumulator. Additionally, the second water line segment is in fluid communication with the water accumulator and the water purifier. | 2017-11-09 |
20170319769 | SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING TESTING THEREOF - A peritoneal dialysis system includes a disposable set, source(s) of concentrate(s), a water purifier, a sensor, and a control unit. The disposable set includes a water port, an inlet port, a drain port, a water line in fluid communication with the water port, a drain line in fluid communication with the drain port, and a container to hold a dialysis fluid prepared by mixing water and the concentrate(s). The source(s) of concentrate(s) are in fluid communication with the inlet port, and the water purifier is configured to purify water and feed the water towards the water port so the sensor can detect a fluid property. The control unit is configured to deliver dialysis fluid mixed in the disposable set to the drain line and water purified by the water purifier along the water line, into the disposable set, and out the drain line to push dialysis fluid to the sensor. | 2017-11-09 |
20170319770 | SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS HAVING POINT OF USE DIALYSIS FLUID PREPARATION INCLUDING MIXING AND HEATING THEREFORE - A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port. | 2017-11-09 |
20170319771 | APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR - An apparatus is described for extracorporeal blood treatment, comprising a treatment unit, an extracorporeal blood circuit and a fluid evacuation line. The apparatus comprises a control unit connected to a pressure sensor and configured to move a blood pump, generating a variable flow with a constant component equal to a desired blood flow value and a variable component having a nil mean value; the variable flow generates, in the expansion chamber, a pressure progression that is variable over time with a pressure component oscillating about a mean value. The control unit receives a plurality of values over a period of time comprising a plurality of oscillations of the pressure about the mean value, calculates a control value representative of the oscillating pressure component, and then determines the verification or not of a condition of variation of the blood level in the expansion chamber. | 2017-11-09 |
20170319772 | VASCULAR ISOLATION SYSTEMS AND METHODS - A system and method enabling the receipt of image data of a patient, identification of one or more locations within the image data depicting symptoms of lung disease, analyzing airways and vasculature proximate the identified locations, planning a pathway to the one or more locations, navigating an extended working channel to one of the locations, identifying the direction of blood flow within vasculature serving the location, positioning a catheter proximate the location, and temporarily isolating a portion of the identified vasculature serving the location depicting symptoms of lung disease. | 2017-11-09 |
20170319773 | SYSTEMS AND METHODS FOR LIMB TREATMENT - A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter. | 2017-11-09 |
20170319774 | ASSEMBLY COMPRISING A SUCTION LINE, A PRESSURE LINE AND A PUMP - An assembly for an extracorporeal life support system with a suction line that features a venous cannula and a pressure line that features an arterial cannula furthermore includes a pump that is arranged between the suction line and the pressure line. This assembly has a discharge line with a discharge cannula, wherein the discharge cannula is longer than the arterial cannula, and wherein the discharge line is connected to the suction line or the pressure line. | 2017-11-09 |
20170319775 | SYSTEMS AND METHODS FOR PERFORMING ONLINE EXTRACORPOREAL PHOTOPHERESIS - Systems and methods for performing online extracorporeal photopheresis of mononuclear cells are disclosed. Whole blood is removed from a patient and introduced through a processing set into a separation chamber to separate the desired cell population from the blood. The separated cell population is processed through the set which is associated with a treatment chamber where the cells are treated. Once treated, the cells are returned to the patient. The processing set remains connected to the patient during the entire ECP treatment procedure and provides an online, sterile closed pathway between the separation chamber and the treatment chamber. | 2017-11-09 |
20170319776 | SYSTEM AND METHOD FOR GUIDED REMOVAL FROM AN IN VIVO SUBJECT - In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through a passageway of an in vivo subject, wherein the flexible tube comprises at least a first passageway and a second passageway. Positioning a distal end of the first passageway in proximity to the object. Infusing liquid through the second passageway substantially continuously. Removing the object through the first passageway with at least a portion of the liquid while suction is not being provided. | 2017-11-09 |
20170319777 | SURGICAL STAPLING INSTRUMENT HAVING A MEDICAL SUBSTANCE DISPENSER - An end effector for use with a surgical instrument includes a plurality of staples, an agent reservoir comprising a medical agent, a dispensing passage configured to convey the medical agent from the agent reservoir to tissue, and a firing system which includes a cutting member, a movable member, and a firing member, wherein the firing system is configured to cooperatively move the movable member and the firing member to simultaneously fire the plurality of staples and dispense at least a portion of the medical agent near the cutting member owing to the advancement of the firing member. | 2017-11-09 |
20170319778 | PUMP FOR OPERATION IN RADIOACTIVE ENVIRONMENT - A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. The system also includes a pump within the enclosure for transferring fluid through tubing. The pump includes a pump head including a casing, a rotor that rotates in relation to the casing, and a clamp. The tubing extends through the pump head. The clamp compresses the tubing against the rotor and directs radioactive fluid through the tubing as the rotor rotates. The pump also includes a servomotor that controls the rotation of the rotor and a coupling connecting the pump head to the servomotor. The coupling prevents backlash between the servomotor and the rotor during rotation. | 2017-11-09 |
20170319779 | Controlled Nucleation From Gas-Supersaturated Liquid - Disclosed is a system to generate bubbles. The bubbles may be formed to include a substantially or medically pure gas. The bubbles may be formed on demand and in a selected small size. | 2017-11-09 |
20170319780 | FAIL-SAFE DRUG INFUSION THERAPY SYSTEM - A fail-safe drug infusion system, including a user interface controller (UIC) and at least one pump motor controller (PMC), with protocols that enable the PMC to operate therapy delivery for a limited amount of time if the UIC fails or the communication link between the UIC and the PMC is interrupted. Includes synchronization methods to synchronize the delivery information back to the UIC after the UIC reboots or after the communication link is restored. The PMC may apply intelligent fail-safe drug infusion therapy by temporarily displaying therapy information, for example information normally displayed by the UIC, while taking control of alarm signaling and providing minimal user control of the therapy until the UIC restores itself, the infusion completes normally, or the user stops the infusion. If the PMC becomes inoperable, the UIC may wait for the PMC to reboot, or attempt to switch infusion channels to provide robust drug infusion. | 2017-11-09 |
20170319781 | INFUSION SITE LEAK DETECTION DEVICE - An infusion set or patch pump is provided for delivering a pharmaceutical agent, such as insulin, to a patient. The infusion set or patch pump has a recessed portion in the bottom face containing a hydrogel and a reactant capable of producing a color change upon contact with the pharmaceutical agent. The reactant includes a mixture of potassium persulfate and 4-aminoantipyrine and optionally horseradish peroxidase, and produces a rapid visually detectable color change when contacted with phenol and/or m-cresol contained in insulin as stabilizing agents. | 2017-11-09 |
20170319782 | Device for Maintaining the Arterial Pressure in a Recommended Target - The invention relates to a method of determining an infusion rate in a medical device to aid with administration of a substance as a function of a physiological parameter and a device adapted to implementation of the method, and a computer program implementing the method. | 2017-11-09 |
20170319783 | APPARATUS AND KITS FOR FLUID INFUSION - An infusion device includes a housing with an interior chamber sized and configured to hold at least a flange and plunger of a syringe, a trigger held by the housing, and a lever in communication with the trigger and including an upwardly extending cam with a cam path having an upper end. The cam is in communication with the flange of the syringe. In response to actuation of the trigger to dispense fluid from the syringe, the upper end of the cam travels upward above the syringe and longitudinally toward a dispensing end of the syringe to linearly translate the plunger of the syringe in a first direction to dispense fluid from the syringe. To refill fluid into the syringe, the upper end of the cam travels downward and longitudinally away from the dispensing end of the syringe to linearly translate the plunger in a second direction to intake fluid. | 2017-11-09 |
20170319784 | Drive Mechanism for use in a Drug Delivery Device - The disclosure is directed to a drive mechanism for use in a drug delivery device having a cartridge, the mechanism comprising a base element, a toothed piston rod movable from a first retracted position corresponding to a full cartridge to a second extended position corresponding to an empty cartridge, wherein the piston rod is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod, wherein the toothed piston rod comprises multiple rigid rod pieces which are connected by hinges, and a drive spring, which is fixed to the base element with one end and fixed to the drive gear with another end and which exerts a force or torque to the drive gear for rotating the drive gear relative to the base element, which rotation results in a movement of the toothed piston rod. The drive spring is charged during manufacture or assembly, wherein the energy stored in the drive spring is sufficient to move the piston rod (from the first to the second position. The disclosure is also directed to a drug delivery device. | 2017-11-09 |
20170319785 | INJECTION DEVICE - An injection device has a plunger for displacing a stopper in a syringe or carpule, a holder for the plunger, a drive for the axial displacement of the holder of the plunger, and a control device functionally assigned to the drive. The plunger, or at least a subcomponent thereof, relative to the holder, the holder is able to move over a limited distance relative to the plunger or a subcomponent thereof, opposing a pretensioning force, in that a sensor device is included which detects the relative position of the plunger, or at least a subcomponent thereof, relative to the holder, which comprises at least one sensor element which works together with the control device. The control device is designed such that, upon activation of the sensor element, the speed of advancement of the holder of the plunger is at least reduced. | 2017-11-09 |
20170319786 | Multi-Compartment Pre-filled Mixing Syringes with Bypass - The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices. | 2017-11-09 |
20170319787 | MEDICATION DEVICE - A medication device with a cartridge or syringe having a longitudinal axis and contains a medicament, a housing receiving the cartridge or syringe and having a center axis, and with an RFID device comprising at least one RFID chip with a first antenna, at least one RFID readout unit with a second antenna), wherein the RFID chip is associated with the cartridge or syringe or housing and the RFID readout unit is associated accordingly with the housing or cartridge or syringe. The medication device is characterized in that the first antenna of the RFID chip and the second antenna of the RFID readout unit are each embodied as a coil and aligned such that they are coaxial with one another and with the longitudinal axis as well as with the center axis. | 2017-11-09 |
20170319788 | SPACE SAVING DRUG INJECTION DEVICE - The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve. | 2017-11-09 |
20170319789 | Pen-Type Injector - The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose cartridge and permit a user to set the delivery dose. The injector may include a housing, a cartridge containing medicinal product, the cartridge being retained within the housing, means for selecting a dose of medicinal product to be expelled, and means for expelling the selected dose of medicinal product. The housing may be a unitary housing within which the means for selecting a dose and the means for expelling the selected dose are moveably retained. Alternatively, the injector may include a housing, a piston rod, an insert located in the housing and through which the piston may rotate, ratchet means, a dose dial sleeve, a drive sleeve, a button located on the drive sleeve and rotatable with respect to the drive sleeve, and clutch means which upon depression of the button prevents rotation between the dose dial sleeve and the drive sleeve. | 2017-11-09 |
20170319790 | Drug Delivery Device with Air-in-Cartridge Safety Feature - A drug delivery device adapted to receive a drug-filled cartridge ( | 2017-11-09 |
20170319791 | Medicament Injection Device - The present disclosure relates to a medicament injection device ( | 2017-11-09 |
20170319792 | A Medical Device - A device for introducing a medicament | 2017-11-09 |
20170319793 | Medicament Delivery Device - A medicament delivery device includes a housing; a hollow plunger rod; a dose drum concentrically arranged between the housing and plunger rod and movable when setting and delivering a dose; and a plunger rod driver. The driver includes a hollow ratchet arm drum movably arranged within the plunger rod and fixed to the dose drum, with the arm drum and rod releasably coupled; a dose activator having a longitudinal rod movably arranged within and releasably coupled to the arm drum; a dose setting knob fixed to the dose activator and releasably coupled to the arm drum; and a resilient element arranged between the arm drum and dose activator that biasses them in a direction decoupling the longitudinal rod from the arm drum and coupling the knob with the arm drum, such that during dose setting, turning the knob forces the arm drum and dose drum to rotate together. | 2017-11-09 |
20170319794 | Seat and Cover system with Medical Units - Aspects of the present invention provide a method for using an apparatus to deliver medicine and to wash, clean, and dry a region of a human body. The apparatus include a toilet seat assembly and a medicine delivery assembly. In addition, the apparatus may include a drying nozzle assembly and/or a spraying nozzle assembly. The medicine delivery assembly may include one or more medicine storage cartridges and/or one or more medicine base units, each medicine base unit includes at least a cartridge unit and at least a cartridges slot, wherein the cartridge slot is adapted to match with a medicine storage cartridge. The medicine delivery assembly may include a medicine delivery nozzle, which can be coupled to a spraying nozzle assembly, or may be operated by itself with a medicine delivery nozzle. Finally, the medicine delivery assembly can be controlled by one or more control units. | 2017-11-09 |
20170319795 | DOSE DELIVERY DEVICE FOR INHALATION - Methods and devices for delivering a dose, such as a medicament, for inhalation. A dose may be stored by a delivery device and dispersed and delivered in a metered fashion to a subject, such as by the subject inhaling via a mouthpiece of the delivery device. One or more chambers of the device may have a toroidal shape and may be arranged to be selectively opened for fluid communication with a flow path of the delivery device, such as by sliding the chamber relative to a portion of the flow path. The flow path may include a restriction that permits air to bypass the chamber, and/or the chamber may be arranged so that fluid entering the chamber interacts with fluid exiting the chamber so as to enhance dispersion of the dose. | 2017-11-09 |
20170319796 | METHODS FOR GENERATING AND DELIVERING DROPLETS TO THE PULMONARY SYSTEM USING A DROPLET DELIVERY DEVICE - A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user. | 2017-11-09 |
20170319797 | DROPLET DELIVERY DEVICE FOR DELIVERY OF FLUIDS TO THE PULMONARY SYSTEM AND METHODS OF USE - A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user. | 2017-11-09 |
20170319798 | DEVICE FOR DISTRIBUTION OF FLUID PRODUCT TRIGGERED BY INHALATION - A fluid dispenser device having a reservoir; a valve; a cocking member movable between rest and primed positions and between primed and dispensing positions, the cocking member includes a set of teeth; a blocking device blocking the cocking member in the primed position; a trigger system controlled by inhaling to release the blocking device; a reservoir support element including a cam opening; and a meshing wheel having a toothed projection co-operating with the set of teeth and a cam projection co-operating with the cam opening. The toothed projection is centered relative to the wheel rotation axis, and the cam projection is offset relative to the axis. The meshing wheel completes a turn when the cocking member moves from its primed towards its dispensing position, such that the cam projection causes the reservoir support element to perform reciprocating axial movement for actuating and returning the valve into its rest position. | 2017-11-09 |
20170319799 | NON-COMBUSTION TYPE FLAVOR INHALER, FLAVOR SOURCE UNIT, AND METHOD FOR MANUFACTURING MEMBER USED IN A NON-COMBUSTION TYPE FLAVOR INHALER - A type flavor inhaler ( | 2017-11-09 |
20170319800 | RESPIRATORY THERAPY APPARATUS - A respiratory therapy apparatus includes a rocker mechanism ( | 2017-11-09 |
20170319801 | System and Method for Automated Titration of Continuous Positive Airway Pressure Using an Obstruction Index - Described is a system including an air pressure supply arrangement, a sensor and a titration device. The air pressure supply arrangement provides air pressure to a patient's airways. The sensor detects input data corresponding to a patient's breathing patterns of a plurality of breaths. The titration device receives and analyzes the input data to determine existence of breathing disorder and corresponding characteristics. The titration device generates output data for adjusting the air pressure supplied to the patient as a function of an index of abnormal respiratory events included in the input data. | 2017-11-09 |
20170319802 | DETECTING COMBUSTION OF A NASAL CANNULA - A system includes a nasal cannula having a flexible tube configured to transmit oxygen gas to a user, an optical fiber coupled to the nasal cannula and configured to transmit light having a frequency spectrum range at least including that of light resulting from combustion of the nasal cannula while transmitting the oxygen gas to the user, a detector operatively coupled to the optical fiber and configured to detect the light transmitted through the optical fiber, and a valve. The valve is configured to be actuated to interrupt the transmission of the oxygen gas to the user through the nasal cannula in response to a signal from the detector. | 2017-11-09 |
20170319803 | DOUBLE CUFF TRACHEOSTOMY DEVICE - This document provides devices and methods for performing tracheostomies. For example, this document provides devices and methods for performing tracheostomies using tracheostomy tubes that include a cuff at the neck opening area that can prevent or reduce the potential for air leaks. | 2017-11-09 |
20170319804 | SMART ETT VENTILATION ATTACHMENT AND METHOD OF USE - An add-on device and method for an Endo-Tracheal Tube (ETT), the add-on device including a lengthy body having a major arc-shaped cross section sized and shaped to tightly fit over an ETT, at least one longitudinal cavity passing along the lengthy body, including a distal suction cavity ending with a suction inlet at a distal end of the lengthy body; and a distal suction outlet channel extending from a proximal end of the lengthy body, the channel is a continuous extension of the distal suction cavity and configured to provide suction to the distal suction cavity. The add-on device senses moisture at a distal end of the add-on device, and in case of detection of excessive wetness, provides suction to the distal end of the device through a cavity passing along the device, the suction is provided via a suction outlet channel extending from a proximal end of the device. | 2017-11-09 |
20170319805 | FLUID DISPENSING CATHETER - A fluid dispensing catheter including an elongate body having a proximal portion and a distal portion and defining a passage between the proximal and distal portions, and a plug having a proximal section positioned within the passage in the distal portion of the elongate body to partially occlude the passage, the plug being substantially cylindrical and having a flat parallel to and offset from a longitudinal axis of the plug, the flat defining a gap with the elongate body. | 2017-11-09 |
20170319806 | Mouth Leak Prevention Device and Leak Prevention Method - A new innovative and unique solution to minimize the problems of mouth leakage using a CPAP machine is disclosed. A mouthpiece module is specifically designed to solve the problem of mouth leakage which compromises the therapeutic effect of CPAP treatment. The mouthpiece module comprises a flexible absorbent material which partially wraps around the lips and is secured to the back of the head by straps or an elastic band. In one embodiment, the mouthpiece is detachable from a securement strap. | 2017-11-09 |
20170319807 | BREATHING ASSISTANCE APPARATUS - A breathing assistance apparatus is disclosed, for use with delivery of respiratory gases to a patient. The breathing assistance apparatus includes a patient interface, having a body section adapted to cover the nose, or nose and mouth of a patient and a sealing interface. The sealing interface includes at least an outer sealing member. The outer sealing member is adapted to attach to the body section in a sealing manner and has a substantially thin section in at least its nasal bridge region. The thin section is substantially thinner than the rest of the outer sealing member. The patient interface comprises a mask body and a seal assembly. The seal assembly includes a flexible seal, and a rigid seal clip, the seal assembly being removably attached to the mask body via the rigid seal clip. The mask body and rigid seal clip are profiled to match the contours of a user's face so that the seal has a substantially constant wall depth. | 2017-11-09 |
20170319808 | PATIENT INTERFACE DEVICE WITH DRAWSTRING ADJUSTMENT - A patient interface device includes a patient sealing assembly having a cushion member and a headgear assembly for securing the patient sealing assembly to a head of the patient. The headgear assembly has a first drawstring, a second drawstring and a locking member structured to be positioned on a top of the head of the patient responsive to the patient interface device being donned by the patient. The first drawstring has a first distal end coupled to a first side of the patient sealing assembly and a first proximal end received through the locking member, and the second drawstring has a second distal end coupled to a second side of the patient sealing assembly and a second proximal end received through the locking member, wherein a fit of the patient interface device may be selectively adjusted using the first drawstring, the second drawstring and the locking member. | 2017-11-09 |
20170319809 | APPARATUS AND METHOD FOR DETECTING LIQUID LEVEL IN A CLEAR OR PARTIALLY CLEAR CONTAINER - A trap bowl is provided to accumulate liquid droplets from a filter, as a liquid content. The trap bowl includes a transparent vertical prism. The transparent vertical prism includes a face that forms a vertical transparent surface facing against a content of the section. The face can provide a first angle of total reflection when content of the section is a type of gas, and a second angle of total reflection when the content of the section is the liquid content. A light source may emit a light beam incident on the face at an angle of incidence. The angle of incidence results in reflection of the light beam, striking the light receiver, when the face has the first angle of total reflection, and results in refraction of the light beam, missing the light receiver, when the face has the second angle of total reflection. | 2017-11-09 |
20170319810 | APPARATUS AND METHOD FOR HUMIDITY CONDITIONING SAMPLE GAS OF A PATIENT BREATHING CIRCUIT AFFILIATED WITH A VENTILATOR AND/OR NITRIC OXIDE DELIVERY SYSTEM - A therapeutic gas is administered to a patient. A sample gas is drawn from the therapeutic gas supply, and passed through a water-permeable tubular membrane. Concurrently, a section of the water permeable tubular membrane is maintained as a ventilated water permeable tubular membrane, by exposing outer surfaces of the ventilated water permeable tubular membrane to an ambient air flow. The ambient air flow may in some examples be moved over the tubular membrane via forced air such as for example via a fan associated with a housing surrounding the tubular membrane. | 2017-11-09 |
20170319811 | HUMIDIFIER UNIT - A low cost medical humidifier for adding moisture to a patient air flow is disclosed. The humidifier comprises a water reservoir, a disposable evaporative wick containing a heater, a lid containing electrical contacts to engage the heater in the wick and airway connections. The wick heater comprises a PET film with aluminium tracks and a cover layer of PTC resistive ink. The heater is covered with paper to provide a water pathway via capillary flow. There is a capillary path from the water reservoir to the wick. The wick and heater are manufactured with printing and calendaring processes in reel to reel processes. | 2017-11-09 |
20170319812 | SYSTEM AND METHOD FOR CONTROLLING LEAK - The present disclosure pertains to a system for controlling a leak flow rate during respiratory therapy. The system is configured to determine a leak flow rate necessary for CO | 2017-11-09 |
20170319813 | Breath Powered Positive Airway Pressure Device - A breath powered positive airway pressure device having an expiratory chamber for receiving expired air from a user. The chamber has at least one resiliently flexible surface that is configured to expand to accommodate the expired air, so that the pressure within the chamber gradually increases during expiration. The device may also include an inspiratory chamber for holding air to be inspired, wherein the at least one resiliently flexible surface forms a flexible partition separating the expiratory chamber from the inspiratory chamber. The flexible partition is configured to expand into the inspiratory chamber during expiration, so that the air that is held within the inspiratory chamber also becomes pressurized during expiration. | 2017-11-09 |
20170319814 | Virtual Reality Medical Application System - Systems and methods are disclosed for monitoring a patient by positioning the patient for a predetermined medical mission; sensing biometric and physical conditions of a patient during the mission, and displaying a multimedia interaction with the patient to keep the patient in a predetermined position to improve efficacy of a medical mission. | 2017-11-09 |
20170319815 | METHOD AND APPARATUSES FOR MODULATING SLEEP BY CHEMICAL ACTIVATION OF TEMPERATURE RECEPTORS - Apparatuses (including devices, kits, and systems) and methods to non-invasively and chemically (rather than thermally) activate thermoreceptors to modulate sleep. For example, described herein are apparatuses including topical compositions that stimulate thermoreceptors on the subject's skin (e.g., forehead, hands, and/or feet) for a period of time to induce a sensation of temperature (heat or cold) without significantly altering the person's actual skin temperature to improve sleep quality, including reducing sleep-onset latency, enhancing depth of sleep, and/or extending the amount of time a subject sleeps. The subject may be suffering from insomnia or some other sleep disorder. | 2017-11-09 |
20170319816 | SLEEP AND WAKE ENVIRONMENT APPARATUS - A sleep and wake environment apparatus includes an aromatherapy diffuser; a speaker; a light source; a clock; and a user interface with controls and a display. Each of these elements are in communication with a control computing device configured to control the aromatherapy diffuser, the speaker, the light source, and the clock automatically and without contemporaneous user input. | 2017-11-09 |
20170319817 | SLEEP GUIDANCE DEVICE, CONTROL METHOD, AND COMPUTER-READABLE RECORDING MEDIUM - Provided is a sleep guidance device that serves to control a stimulus imparter for imparting stimuli to a human subject. The sleep guidance device acquires a biorhythm of the human subject; estimates sleep depths of the human subject from the acquired biorhythm of the human subject; and controls the stimulus imparter to impart a stimulus to the human subject in accordance with the acquired biorhythm of the human subject, and from among the sleep depths, a current sleep depth estimated for the human subject. | 2017-11-09 |
20170319818 | DRUG DELIVERY DEVICE - The present disclosure provides for a fluid delivery device for a body vessel and a method of use. The fluid delivery device may have an elongate member having a proximal end extending along the longitudinal axis to a closed distal end. The elongate member may also have an inner wall defining a fluid delivery lumen and a wire guide lumen. The elongate member may have a tapered region and a distal portion between the proximal and distal ends. The device may have a first state for device delivery to the treatment site. | 2017-11-09 |
20170319819 | Multi-Lumen Catheter With Enhanced Flow Features - A method for forming a catheter tube assembly includes providing a reinforcement structure and disposing a catheter tube over the reinforcement structure. The reinforcement structure includes a first outer wall reinforcement portion, a second outer wall reinforcement portion, and a septum reinforcement portion connecting the first outer wall reinforcement portion to the second outer wall reinforcement portion. The catheter tube includes an outer wall and a septum. The catheter tube is disposed over the reinforcement structure such that the catheter tube septum envelopes the septum reinforcement portion of the reinforcement structure. | 2017-11-09 |
20170319820 | VENOUS ACCESS CATHETERS AND METHODS FOR PORTAL VENOUS SYSTEM CATHETERIZATION - The present invention contemplates devices and methods to administer nutritional compositions and/or therapeutic drugs directly into a portal venous system. For example, total parenteral nutrition therapy may be administered directly into the hepatic portal venous system thus circumventing known side effects of conventional parenteral administration. Alternatively, hepatic diseases and disorders may be treated using locally administered therapeutic drugs. Devices capable of direct portal venous system administration include, but are not limited to, a direct portal access catheter or a transjugular access catheter. | 2017-11-09 |
20170319821 | MEDICAL DEVICES HAVING RELEASABLE COUPLING - This invention is directed to a medical device having a longitudinal axis, and including a handle and a catheter. The handle can include a body having a proximal end and a distal end, an actuator moveably coupled to the body, and a handle control member coupled to the actuator, wherein the actuator can be configured to move relative to the body to move the handle control member. The catheter can include a shaft having a proximal end and a distal end, wherein the proximal end of the shaft and the distal end of the body can be configured for releasable coupling. The catheter can also include a steering section located along the shaft and a catheter control member coupled to the steering section, wherein the catheter control member can be configured to move relative to the shaft to move the steering section relative to the longitudinal axis. The medical device can also include a securing member configured to move relative to at least one of the handle and the catheter to releasably couple the handle control member to the catheter control member. | 2017-11-09 |
20170319822 | Intravenous Catheter Assembly - An intravenous catheter assembly comprises a catheter hub having an elongate axis and a lumen; a side port extending from the catheter hub, the side port being in fluid communication with the lumen; and a one-way port valve positioned in the side port, the one-way port valve having a valve portion formed from a resilient material. The valve portion can comprise a cap and a hinge portion about which the cap is rotatable. The cap can be disposed over an aperture formed in an inclined end face of the valve portion. | 2017-11-09 |
20170319823 | APPARATUS AND METHODS FOR DELIVERING DEVICES FOR REDUCING LEFT ATRIAL PRESSURE - A device for regulating blood pressure between a patient's left atrium and right atrium, and apparatus for delivery the device, are provided. The delivery apparatus may include one or more latching legs, a release ring, a pull chord, and a catheter wherein the latching legs are configured to engage the device for delivery. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies. | 2017-11-09 |
20170319824 | REMOTE CATHETER PROCEDURE SYSTEM - A catheter procedure system including a bedside system and a remote workstation is provided. The bedside system includes a catheter including an expandable percutaneous intervention device, a robotic catheter system configured to move the catheter, and an inflation device configured to cause expansion of the expandable percutaneous intervention device. The remote workstation includes a user interface configured to receive a at least first user input and a second user input and a control system operatively coupled to the user interface for remotely controlling both the robotic catheter system and the inflation device. The remote workstation includes a monitor configured to display information related to the expandable percutaneous intervention device. The control system controls the robotic catheter system to move the catheter based upon at least the first user input and controls the inflation device to cause expansion of the expandable percutaneous intervention device based upon at least the second user input. | 2017-11-09 |
20170319825 | INTRAVASCULAR CATHETER ASSEMBLY - A peripheral intravascular catheter assembly comprising a tubular introducer needle and an adapter connected to the proximal end of the light guide. An introducer needle comprises a connection hub and a needle member. The needle member has a lumen, a distal end and a proximal end. The assembly may be further provided with a cannula tubing surrounding at least a portion of the needle member, with at least one light source and with an electronic module, configured to power the light source. The light guide has a distal end and a proximal end and extends along the lumen of the needle member. The adapter may be connected to the electronic module to the connection hub of the introducer needle so that light emitted by at least one light source is capable of entering the light guide, but blood flowing through the lumen of the needle member is prevented from contacting said light source. | 2017-11-09 |
20170319826 | STEERABLE GUIDEWIRE SYSTEM - A catheter system utilizing one or more sensors is described. The catheter can be used as part of an embolic coil system, guidewire system, or combined embolic coil/guidewire system where the devices interact with the catheter system. A variable detachment embolic coil system and guidewire system are also described. | 2017-11-09 |
20170319827 | INTERLOCKING LOW PROFILE GRIPPING DEVICE - A low profile gripping device having a locking assembly attached to a base, wherein the locking assembly comprises a locking strap with pairs of fins disposed for insertion into an aperture of a buckle. The locking assembly comprises an anchor block having opposing sides, the locking strap attached to one side, and the buckle attached to the opposing side. The interface between the locking strap and the anchor block forms a creased groove for seating a flexible polymer tube or polymer coated cable. The locking strap is inserted through the aperture to secure the tube or cable in the creased groove, and the fins retain the locking strap in fixed relation to the buckle. | 2017-11-09 |
20170319828 | WIRE LOCK ASSEMBLY - A wire lock assembly for an access port of an elongate medical tube includes a body having an exterior surface, an interior surface, and a central opening disposed therethrough, an attachment mechanism disposed through the exterior surface of the body, the attachment mechanism having an open end and a closed end, at least one notch arranged on the body and positioned proximate to the central opening and at least one seal supported within the interior surface of the body in communication with the central opening, the seal comprising a passageway therethrough, where the interior surface of the body defines a non-linear pathway for securing one or more medical devices. | 2017-11-09 |
20170319829 | COMFORMABLE BALLOON DEVICES AND METHODS - The present disclosure is directed toward a semi-compliant to non-compliant, conformable balloon useful in medical applications. Conformable balloons of the present disclosure exhibit a low straightening force when in a curved configuration and at inflation pressures greater than 4 atm. Balloons of the present disclosure are constructed of material that can compress along an inner length when the balloon is in a curved configuration. In further embodiments, balloons of the present disclosure can be constructed of material that sufficiently elongates along an outer arc when the balloon is in a curved configuration. As a result, medical balloons, in accordance with the present disclosure, when inflated in a curved configuration, exhibit kink-free configurations and do not cause a significant degree of vessel straightening. | 2017-11-09 |
20170319830 | COMBINATION WOUND DRAIN AND SUBSTANCE-DELIVERY SYSTEM AND METHOD - A combination wound drain and substance-delivery device includes a drain portion and a substance delivery portion. The drain portion and the substance-delivery portion include interior cavities that are separated from one another to prevent fluids and/or materials disposed within the interior cavities from mixing together. Each of the interior cavities includes one or more perforations that allow fluid communication between a wound site and each of the interior cavities. The device further includes a tip coupled to the drain portion that facilitates removal of collected waste from the drain portion. The device may include an attachment mechanism that helps secure the device when placed within a wound site. | 2017-11-09 |
20170319831 | NEUROSURGICAL APPARATUS - A high-strength steel sheet and a method for manufacturing a high-strength steel sheet having excellent phosphatability and excellent corrosion resistance after electrodeposition coating has been performed, even in the case where the contents of Si and Mn are high. The method may comprise annealing a steal sheet by using a continuous annealing method, performing a heating process, controlling the maximum end-point temperature of a steel sheet in the annealing furnace, controlling the traveling time of the steel sheet, and controlling the dew point of the atmosphere. | 2017-11-09 |
20170319832 | DEVICES FOR HYDRATING PATIENTS - A method, device, and kit for providing fluid to a patient, the device includes a food-contact-safe sponge and a handle, the handle supporting the sponge. | 2017-11-09 |
20170319833 | INTRAVAGINAL DRUG DELIVERY DEVICE - Described herein is an intravaginal drug delivery system. In an embodiment the intravaginal drug delivery system includes a progestin and estrogen compound, and releases the active ingredients in a fixed physiological ratio over a prolonged period of time to produce a contraceptive state in a female. | 2017-11-09 |
20170319834 | DEVICES AND METHODS FOR INTRALUMINAL RETENTION AND DRUG DELIVERY - Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject. | 2017-11-09 |
20170319835 | TIPS FOR SKIN TREATMENT DEVICE - An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to the console and controlled by the user input device. The manifold system is configured to hold releasably a plurality of fluid sources and deliver fluid from at least one of the plurality of fluid sources to the handpiece assembly. | 2017-11-09 |
20170319836 | REMOVABLE TIPS FOR USE WITH SKIN TREATMENT SYSTEMS - An apparatus for treating skin has a console with a user input device and a handpiece assembly. The handpiece assembly is configured to treat skin. A fluid line provides fluid communication between the console and the handpiece assembly. A manifold system is coupled to the console and controlled by the user input device. The manifold system is configured to hold releasably a plurality of fluid sources and deliver fluid from at least one of the plurality of fluid sources to the handpiece assembly. | 2017-11-09 |
20170319837 | DISPENSING APPLICATOR FOR FLUIDS - A single-piece, injection molded, hand-held liquid dispensing applicator. The single-piece applicator comprising a source of fluid and a frangible applicator tip attached to the fluid source. When the frangible applicator tip is broken, the fluid flows from the source to an absorbent member attached to the applicator tip to spread the liquid on a surface. The frangible tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region therebetween. The tongue element may comprise ribs for reinforcement. The frangible tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. The dispensing applicator may be used in various medical applications. | 2017-11-09 |
20170319838 | DISPENSING APPLICATOR FOR FLUIDS - A liquid dispensing applicator may include a liquid source for housing a liquid, the liquid source having a first end and a second end, the second end being closed; a swab member for dispensing said liquid, the swab member being disposed at the first end; and at least one capillary member being in fluid communication with the liquid source, the capillary tube directing fluid out from the liquid source onto an exterior of the swab member upon application of pressure to the liquid source. A liquid dispensing applicator may also include an applicator tip fluidically connected to the liquid source including a frangible juncture and a tongue member coupled to the frangible junction, application of force to the tongue member causing the frangible junction to fracture while remaining attached to the tongue member, resulting in at least one aperture to form through which liquid from the liquid source is dischargeable. | 2017-11-09 |
20170319839 | MICROPENETRATOR DEVICE FOR PENETRATING A BIOLOGICAL BARRIER - A device that may be placed on a biological barrier can be used to perforate the biological barrier for a variety of purposes such as cosmetic, scar treatment or for the delivery of active agents. A flexible substrate has a first side and a second opposing side and a plurality of micro-penetrator arrangements each comprising a head and a first and second projection, for penetrating a biological barrier, extending from the head. The first and second projection at least partially extend through the flexible substrate towards the first side. The head comprises an elongate arm for spacing apart the first and second projections. A force is applied to the second side causing flexing of the flexible substrate and pushing the projections into communication with a biological barrier. | 2017-11-09 |
20170319840 | USING ULTRASOUND SHEAR-WAVES TO ENHANCE SKIN PERMEABILITY - Described embodiments include a system, method, and apparatus. A system includes an extracellular-fluid collection device configured to be positioned at a location on a skin of a mammal. In an embodiment, the mammal includes a live human. The system includes an ultrasonic wave transmitter configured to emit ultrasonic shear waves directable at the location. The ultrasonic shear waves have a frequency or amplitude selected to increase a permeability of the skin of the mammal to an extracellular-fluid. In an embodiment, the system includes a sensor configured to determine a rate or amount of extracellular-fluid collected by the extracellular-fluid collection device. In an embodiment, the system includes a fluid collection controller configured to regulate a parameter of ultrasonic shear waves transmitted by the ultrasonic wave transmitter in response to a determined rate or amount of fluid collected by the extracellular-fluid collection device. | 2017-11-09 |
20170319841 | USING ULTRASOUND SHEAR-WAVES TO ENHANCE SKIN PERMEABILITY - Described embodiments include a system, method, and apparatus. A system includes a medicament-eluting device configured to be positioned at a location on a skin of a mammal. The system includes an ultrasonic wave transmitter configured to emit ultrasonic shear waves directable at the location. The ultrasonic shear waves have a frequency or amplitude selected to increase a permeability of the skin of the mammal to a medicament released by the medicament-eluting device. In an embodiment, the system includes a structure carrying the medicament-eluting device and the ultrasonic wave transmitter. In an embodiment, the system includes a cavitation sensor configured to detect a cavitation event in the mammal. In an embodiment, the system includes a cavitation controller configured to limit a power of the ultrasonic shear waves directed at the location to a level below a cavitation threshold of the mammal. | 2017-11-09 |
20170319842 | Overmolded Access Port Including Anchoring And Identification Features - An access port for providing subcutaneous access to a patient is disclosed. In one embodiment, the port includes an internal body defining a fluid cavity that is accessible via a septum. A compliant outer cover including silicone is disposed about at least a portion of the body. A flange is included with the port body and is covered by the outer cover. The flange radially extends about a perimeter of the port body proximate the septum so as to impede penetration of a needle substantially into the outer cover in instances where the needle misses the septum. The flange can further include both an anchoring feature for securing the outer cover to the port body and an identification feature observable via x-ray imaging technology for conveying information indicative of at least one attribute of the access port. The outer cover provides a suitable surface for application of an antimicrobial/antithrombotic coating. | 2017-11-09 |
20170319843 | APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME - A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude. | 2017-11-09 |
20170319844 | WEARABLE BAND FOR LOW-FREQUENCY THERAPY - The present invention relates to a wearable band for low frequency therapy and, more specifically, to a wearable band for low frequency therapy, the wearable band enabling a wearer to connect to a low frequency therapy device while wearing, on a body part, a cylindrical wearable band in which knitted pile yarn is formed from conductive fiber, thereby providing low-frequency stimulation to the part of the wearer's body such that the wearer can receive physical therapy. | 2017-11-09 |
20170319845 | DELIVERY TOOLS IN IMPLANTABLE DEFIBRILLATOR SYSTEMS - Tunneling tools and systems comprising electrodes and tunneling tool. In some examples the tunneling tools have a width that is greater than thickness, or may have enlarged portions to allow tunneling of a space. The tunneling tools may have expandable dissection portions including expandable balloons, linkages and/or springs in different examples. Systems may include tunneling tools with a lumen for receiving a lead having an electrode in a collapsed configuration, where the electrode is designed to expand once placed in a patient, with the tunneling tool designed to create a space in which the electrode can expand. | 2017-11-09 |
20170319846 | IMPLANTABLE ELECTRODE ARRANGEMENT - An implantable electrode arrangement provides spatially-selective detection of neuronal electrical signals, which propagate along at least one nerve fiber contained in a nerve fascicle, and for selective electrical stimulation of the at least one nerve fiber, comprising a biocompatible carrier substrate, which has at least one carrier substrate region that can be placed around the nerve fascicle in a cuff and has a straight cylinder-shaped carrier substrate surface which faces the nerve fascicle in the implanted state. The carrier substrate surface has an axial extension and an extension oriented circumferentially in a direction and a first electrode arrangement attached thereto. The electrode arrangement comprises in an axial sequence, at least three first electrode structures with at least two first electrode surfaces arranged in the circumferentially, and at least two spaced first electrode strips, displayed in the axial direction which extend circumferentially which are in a ring shape, which encloses the at least three electrode structures on both sides in the axial direction. The electrodes are connectable or are connected to a signal detector and generator. | 2017-11-09 |