45th week of 2017 patent applcation highlights part 25 |
Patent application number | Title | Published |
20170321149 | PREPARATION OF STEARIC ACID - One or more techniques are disclosed for a process of preparing stearic acid from animal and/or plant sources may comprise: 1) deodorizing and distilling a fat; 2) concentrating fatty acids of the fat; and 3) hydrogenating the fatty acid to provide stearic acid. The process may include the use of co-products from plant and/or animal sources. The process may also include distilling the stearic acid to provide palmitic acid and/or fully hydrogenated fatty acid. Tallow fatty acid, vegetable fatty acid, stearic acid, and palmitic acid prepared from the process described are also disclosed. | 2017-11-09 |
20170321150 | BURNER CUP - A device has a canister with a bulk wick occupying at least most of the canister, and a lid affixed to the canister and in contact with the bulk wick. The lid defines an opening exposing a portion of the bulk wick for lighting. | 2017-11-09 |
20170321151 | ACID LIQUID COMPACT WASHING AGENT INCLUDING HYDROXYCARBOXYLIC ACID, NON-IONIC SURFACTANT, AND AN-AMYLASE - The invention relates to liquid washing agents having a pH value of <6.5, preferably in the range of 2 to 5, containing, based on the total weight of the liquid washing agent, (i) 5 to 30% by weight, preferably 10 to 30% by weight, in particular 15 to 25% by weight of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms, (ii) 15 to 55% by weight, preferably 20 to 55% by weight, in particular 35 to 50% by weight of at least one non-ionic surfactant, (iii) 0 to 20% by weight of water, and (iv) at least one α-amylase having a pH optimum of pH <7. Said liquid washing agents have an increased cleaning power, in particular on stains on the basis of components and residues from deodorants but also of grates, berries, tea and red wine residues. | 2017-11-09 |
20170321152 | ACID LIQUID COMPACT WASHING AGENT INCLUDING HYDROXYCARBOXYLIC ACID, NON-IONIC SURFACTANT, AND AN ENZYME - The invention relates to liquid washing agents having a pH value of <6.5, preferably in the range of 2 to 5, containing, based on the total weight of the liquid washing agent, (i) 5 to 30% by weight, preferably 10 to 30% by weight, in particular 15 to 25% by weight of at least one hydroxycarboxylic acid having 2 to 8 carbon atoms, (ii) 15 to 55% by weight, preferably 20 to 55% by weight, in particular 35 to 50% by weight of at least one non-ionic surfactant, (iii) 0 to 20% by weight of water, and (iv) at least one enzyme having a pH optimum of pH<7. Said liquid washing agents have an increased cleaning power, in particular on stains on the basis of components and residues from deodorants but also of grates, berries, tea and red wine residues. | 2017-11-09 |
20170321153 | STABLE LIQUID MANUAL DISHWASHING COMPOSITIONS CONTAINING ENZYMES - Liquid stable enzyme compositions and methods of employing the same for cleaning, including warewashing and dishwashing, are disclosed. The stable enzyme compositions preferably employ an amphoteric surfactant stabilizing agent, such as disodium camphodiacetate (CADA), to stabilize a mixture of traditionally unstable enzymes, such as proteases and lipases. | 2017-11-09 |
20170321154 | Laundry Detergents Containing Soil Release Polymers - The invention relates to liquid laundry detergent compositions comprising
| 2017-11-09 |
20170321155 | SILICA-BASED STRUCTURANTS AND PROCESSES FOR MAKING THEREOF - The disclosure relates to a silica-based structurant and methods of making such a structurant. According to one embodiment, the structurant may include 55 wt % to 90 wt % of a silica having a [Na | 2017-11-09 |
20170321156 | Bottle Cleaning Powder and Tablet - The present invention relates to a quick rinse detergent cleaner. The detergent contains high levels of salt that immediately collapse soap bubbles, so that less rinsing (and re-rinsing) of utensils is required. This allows for greater portability and applications relative to existing cleaning solutions. | 2017-11-09 |
20170321157 | AUTOMATIC DISHWASHING DETERGENT COMPOSITION - A phosphate-free automatic dishwashing cleaning composition including an organic complexing agent and a new protease. | 2017-11-09 |
20170321158 | AUTOMATIC DISHWASHING DETERGENT COMPOSITION - Bleach-containing automatic dishwashing cleaning composition including a new amylase. | 2017-11-09 |
20170321159 | AUTOMATIC DISHWASHING DETERGENT COMPOSITION - Phosphate-free automatic dishwashing detergent composition including a new amylase. | 2017-11-09 |
20170321160 | DETERGENT COMPOSITION - A detergent composition including an oleic acid-transforming enzyme and a surfactant system. Furthermore, a method of manually washing articles including the steps of: delivering a composition including an oleic acid-transforming enzyme and a surfactant system to a volume of water to form a wash liquor and immersing the soiled articles, in the liquor. | 2017-11-09 |
20170321161 | DETERGENT COMPOSITION - Use of a detergent composition comprising a fatty acid-transforming enzyme to impart suds longevity in a washing process. A method for promoting suds longevity in a washing process for washing soiled articles, comprising the step of: delivering a composition comprising a fatty acid-transforming enzyme to a volume of water to form a wash liquor and immersing the soiled article in the liquor. | 2017-11-09 |
20170321162 | DETERGENT COMPOSITION - A detergent composition, preferably a manual dishwashing detergent composition comprising a surfactant system and a fatty acid decarboxylase enzyme and method of manually washing soiled articles, comprising the step of: delivering a composition to a volume of water to form a wash liquor and immersing the soiled articles, in the wash liquor, or delivering a composition optionally in the presence of water, directly onto a soiled article, or onto a cleaning implement, and using the cleaning implement to clean the soiled article. | 2017-11-09 |
20170321163 | ENZYME STABILIZERS - The present disclosure relates to detergents and cleaning agents, comprising at least one protease and at least one organic compound of formula (I), said compound acting as a protease inhibitor and thus being a suitable enzyme stabilizer, and to the use of said compounds as enzyme stabilizers in protease-containing detergents and cleaning agents. The disclosure further relates to the corresponding washing and cleaning methods and to the use of the agents described herein. | 2017-11-09 |
20170321164 | DISHWASHER DETERGENT CONTAINING METAL COMPLEXES - The present disclosure relates to an automatic dishwasher detergent which comprises metal complex of formula M | 2017-11-09 |
20170321165 | TWO STEP METHOD OF CLEANING, SANITIZING, AND RINSING A SURFACE - Methods employing detergent compositions comprising phosphinosuccinic acid oligomers (PSO) in combination with a sanitizing rinse aid are disclosed. The methods beneficially clean, sanitize and rinse a surface in an efficient two-step process. The detergent compositions employ phosphinosuccinic acid adducts, namely mono-, bis- and oligomeric phosphinosuccinic acid (PSO) derivatives, in combination with an alkalinity source and optionally polymers and/or surfactants. The sanitizing and rinsing compositions employ peroxycarboxylic acid compositions in combination with a nonionic defoaming and wetting surfactant. | 2017-11-09 |
20170321166 | LAUNDRY ADDITIVE - A laundry additive composition comprising a) at least one oxylated material chosen from polyoxyalkylene, a poly-oxyalkylene fatty acid ester, and a polyoxyalkylene fatty alcohol ether; b) a polyol; c) a coloring agent; and d) at least one additive chosen from fragrance and a fabric treatment material. The composition can deliver the additive to clothing during washing or rinsing of the clothes, such as to impart a fragrance to clothing. | 2017-11-09 |
20170321167 | Azeotropic Composition Having Fluorine-Containing Olefin as Constituent - A liquid composition according to one embodiment of the present invention contains 0.0001 mol % to 40 mol % (Z)-1,2-dichloro-3,3,3-trifluoropropene (1223Z) and 99.9999 mol % to 60 mol % (E)-1,2-dichloro-ethylene (t-DCE). The liquid composition has less influence on the global environment and azeotropic (or azeotrope-like) properties. There occurs practically no composition change even when the liquid composition is used in an open system or used for a long term. Further, it is less likely that there will occur a composition change even when the liquid composition is recovered by distillation. The liquid composition is thus suitably usable as a cleaning agent (solvent). In particular, the liquid composition of 90 mol % or less of t-DCE is classified as non-hazardous under the Fire Serves Act. | 2017-11-09 |
20170321168 | POLYIMIDE-BASED RESIN FILM CLEANING LIQUID, METHOD FOR CLEANING POLYIMIDE-BASED RESIN FILM, METHOD FOR PRODUCING POLYIMIDE COATING, METHOD FOR PRODUCING FILTER, FILTER MEDIUM, OR FILTER DEVICE, AND METHOD FOR PRODUCING CHEMICAL SOLUTION FOR LITHOGRAPHY - A polyimide-based resin film cleaning liquid includes at least one solvent selected from the group consisting of a hydroxy aliphatic carboxylic acid ester, an aliphatic carboxylic acid ester, a chain or cyclic ketone, an alkylene glycol monoalkyl ether, an alkylene glycol monoalkyl ether acetate, and an aprotic polar solvent other than these solvents. | 2017-11-09 |
20170321169 | CLEANING COMPOSITIONS - A cleaning composition, preferably a granular laundry detergent composition, contains 1.5 wt % to 10 wt % of soap particles characterized by a particle size distribution with from 35 wt % to 100 wt % of soap particles having particle sizes ranging from about 125 microns to about 355 microns. Soap particles with such a particle size distribution are surprisingly more effective in boosting suds volume of the cleaning composition during a fabric washing cycle. | 2017-11-09 |
20170321170 | CLEANING COMPOSITION - A cleaning composition comprising a particle said particle comprising: (a) from 30 to 70% by weight thereof of a polymer having a softening point in the range from about 20° C. to about 60° C.; (b) from 20 to 60% by weight thereof of a first material having a BET surface area greater than 100 m2/g and a D50 from about 5 to about 20 μm; (c) from 3 wt % to 15% by weight thereof of a second material having a BET surface area from about 0.01 to about 5 m2/g and a D50 from about 30 to about 100 μm. | 2017-11-09 |
20170321171 | Dyed Coated Bleach Materials - The invention relates to dyed particles of a bleach material that comprise a coating. The invention also relates to the use of the dyed particles in detergent compositions. | 2017-11-09 |
20170321172 | DISPERSIBLE PACKAGING FOR TOILET PAPER MOISTENER PRODUCT - A water dispersible pouch for moistening a tissue includes a film that encloses a cavity, the film having a body portion and a region of weakness, the region of weakness having a thickness that is less than a thickness of body portion; and a substantially waterless wetting composition disposed within the cavity; wherein the water dispersible pouch has a rupture strength at the region of weakness of less than 10 pounds per square inch (psi). | 2017-11-09 |
20170321173 | FERMENTATION COOLING SYSTEM - A fermentation system having a vessel defining a chamber for holding liquids and including a lower aperture. An insulating jacket is disposed around the vessel. A cooling fluid is disposed between the insulating jacket and the vessel. The cooling fluid is in fluid communication with a fluid pump. A refrigerant line is wrapped around the vessel and is configured to cool the fluid and the vessel, resulting in cooling of liquids disposed in the chamber. A beverage line operably couples the lower aperture with a dispensing spigot. The beverage line is wrapped around the vessel and is at least partially submerged in the fluid. A sediment drain line is disposed below the lower aperture and configured to drain sediment that accumulates on a bottom of the vessel. | 2017-11-09 |
20170321174 | Fermentation Methods - A fermentation method and system which includes providing juice to be fermented into a container. The juice having a cap that is a collection of solid components of grapes. The cap has a permeable consistency and floats in the juice. The method includes moving a portion of the juice from below the cap upward into contact with the cap. | 2017-11-09 |
20170321175 | METHOD AND DEVICE FOR CONTROLLED AIR INJECTION INTO A VINIFICATION TANK - A method and a device for air injection into a vinification tank ( | 2017-11-09 |
20170321176 | CELL SHEET MANUFACTURING DEVICE AND MANUFACTURING METHOD THEREFOR - The present invention relates to a cell sheet manufacturing device and a manufacturing method therefor. More specifically, the present invention relates to a cell sheet manufacturing device comprising a support layer made of silicon rubber, a patterned electrode formed adjacent to the support layer and a graphene layer formed adjacent to the electrode, and a manufacturing method therefor. | 2017-11-09 |
20170321177 | ACOUSTIC WAVES IN MICROFLUIDICS - Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting. | 2017-11-09 |
20170321178 | THREE-DIMENSIONAL BIOREACTOR FOR CELL EXPANSION AND RELATED APPLICATIONS - The present disclosure relates to the design, fabrication, and applications of a three-dimensional (3D) bioreactor for cell expansion and cell secreted substance production. The bioreactor is composed of non-random interconnected voids providing a continuous three-dimensional surface area for cell adherence and growth. | 2017-11-09 |
20170321179 | ALGAE CULTIVATION SYSTEMS AND METHODS ADAPTED FOR WEATHER VARIATIONS - Algae cultivation systems and methods account for weather variations that can affect algae cultivation. In one system, an open raceway algae cultivation system includes a channel having a high section and a low liquid collection section. The channel is sloped to allow substantially all of an algae cultivation fluid in the high section to flow downwardly into the low liquid collection section. A barrier is removably positioned in the high section and a drain is positioned in the high section such that, when substantially all of the algae cultivation fluid has collected in the low liquid collection section, any rainwater that falls in the high section flows into the drain, without the rainwater mixing with the algae cultivation fluid in the low liquid collection section. | 2017-11-09 |
20170321180 | Stacked Membrane Bioreactor - Scalable biomaterial-based bioreactors are described. In one embodiment, the bioreactor may comprise perforated plates stacked such that the assembled bioreactor has the necessary manifolds and chambers to transport gas and liquids to a biomaterial contained within the bioreactor, and to remove the reaction products. In another embodiment, single use bioreactors are described. Methods of operating the bioreactors are also described. | 2017-11-09 |
20170321181 | BIOLOGICAL AND ALGAE HARVESTING AND CULTIVATION SYSTEMS AND METHODS - Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced. | 2017-11-09 |
20170321182 | BIOLOGICAL AND ALGAE HARVESTING AND CULTIVATION SYSTEMS AND METHODS - Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced. | 2017-11-09 |
20170321183 | Cell Isolation Method and Cell Trapping Filter - A cell isolation method includes: a cell trapping step of allowing a test liquid to pass through a cell trapping filter which has a plurality of through-holes in the thickness direction, thereby trapping isolation target cells contained in the test liquid on one surface of the cell trapping filter; a gel embedding step of introducing a stimulus-responsive hydrogel onto the one surface of the cell trapping filter on which the cells have been trapped in the cell trapping step, thereby embedding the cells in the stimulus-responsive hydrogel; a gel hardening step of applying a stimulus to the stimulus-responsive hydrogel in which the cells are embedded, thereby hardening the stimulus-responsive hydrogel; and a detachment step of detaching the stimulus-responsive hydrogel that was hardened in the gel hardening step from the cell trapping filter. | 2017-11-09 |
20170321184 | BIOLOGICAL AND ALGAE HARVESTING AND CULTIVATION SYSTEMS AND METHODS - Algae harvesting and cultivating systems and methods for producing high concentrations of algae product with minimal energy. In an embodiment, a dead-end filtration system and method includes at least one tank and a plurality hollow fiber membranes positioned in the at least one tank. An algae medium is pulled through the hollow fiber membranes such that a retentate and a permeate are produced. | 2017-11-09 |
20170321185 | EFFICIENT PRODUCTION OF OLIGOSACCHARIDES USING METABOLICALLY ENGINEERED MICROORGANISMS - The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moieties of the gangliosides GM3, GD3, and G. | 2017-11-09 |
20170321186 | PROCESS FOR IMPROVING THE SOLUBILITY OF CELL CULTURE MEDIA - The invention relates to a process for improving the solubility of dry cell culture media. Some dry powder cell culture media show poor dissolving properties and result in turbid solutions when they are dissolved in aqueous solutions. Using a stepwise procedure in which the amino acids present in the non-dissolving part are identified and added to a new batch in other particle sizes significantly reduces that problem. | 2017-11-09 |
20170321187 | BIOLOGICALLY ACTIVE C-TERMINAL ARGININE-CONTAINING PEPTIDES - The present invention concerns the separation, identification and characterization of active peptide fragments from peptones. | 2017-11-09 |
20170321188 | METHODS OF GENERATING RETINAL PROGENITOR CELL PREPARATIONS AND USES THEREOF - The present invention relates to methods of generating preparations of neural progenitor cells and retinal progenitor cells from populations of stem cells. These methods involve the administration of Tbx3 alone or in combination with Pax6. The preparations of neural and retinal progenitor cells prepared in accordance with the methods disclosed herein are suitable for use in methods of treating individuals having retinal disorders. | 2017-11-09 |
20170321189 | Co-Differentiation Of Monocytes From Allogeneic Donors - Disclosed is a method of producing non-exhausted immature dendritic cells (DCs) originating front at two different, allogeneic donors. In the method, a mixture of allogeneic leukocytes, which allogeneic leukocytes have been obtained from at least two different, allogeneie donors is provided. Subsequently, allogeneic monocytes are isolated from the mixture of allogeneic leukocytes. Thereafter, non-exhausted immature DCs are generated from said isolated allogeneic monocytes. | 2017-11-09 |
20170321190 | METHODS TO GENERATE EPITHELIAL CELLS - The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell. The invention provides in certain embodiments, re-programmed differentiated epithelial cells, and methods of using these re-programmed differentiated epithelial cells to repair or re-generate tissue in vivo. | 2017-11-09 |
20170321191 | METHOD FOR PREPARING BONE MARROW CELL AGGREGATE - The present invention provides a technique which enables organization of bone marrow cells by a simple method in a short period of time. | 2017-11-09 |
20170321192 | Recombinant RNA Viruses and Uses Thereof - Described herein are modified RNA virus gene segments and nucleic acids encoding modified RNA virus gene segments. Also described herein are recombinant RNA viruses comprising modified RNA virus gene segments and the use of such recombinant RNA viruses for the prevention and treatment of disease. | 2017-11-09 |
20170321193 | VARIANT FORMS OF URATE OXIDASE AND USE THEREOF - Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidase are described. | 2017-11-09 |
20170321194 | MODULATION OF LIPID METABOLISM FOR PROTEIN PRODUCTION - The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. Also encompassed by the present disclosure are engineered cells with improved production capacity and improved product quality, methods for engineering such cells, and preparations and mixtures comprising the products from such cells. | 2017-11-09 |
20170321195 | POLYMERASES - Presented herein are methods and compositions for thermostable DNA polymerases that may be used to improve the PCR process and to improve the results obtained when using a thermostable DNA polymerase in other recombinant techniques such as DNA sequencing, nick-translation, and reverse transcription. | 2017-11-09 |
20170321196 | ANALYTICAL AND DIAGNOSTIC METHODS UTILIZING SHIGELLA FLEXNERI APYRASE - A method, comprising the steps of providing a sample containing contaminating nucleoside diphosphates and/or nucleoside triphosphates, such as ATP and/or ATP analogues including deoxyribonucleoside triphosphates; reducing the amount of the contaminating nucleoside diphosphates and/or nucleoside triphosphates in the sample with an apyrase enzyme, wherein said apyrase enzyme is a | 2017-11-09 |
20170321197 | Lipase Variants and Polynucleotides Encoding Same - The present invention relates to a variant of a parent lipase, which parent lipase has the amino acid sequence of SEQ ID NO: 2, wherein the variant has lipase activity, comprises a substitution at a position corresponding to position 51 and comprises a substitution or remains unaltered at a position corresponding to position 96 of SEQ ID NO: 2. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2017-11-09 |
20170321198 | NOVEL CRISPR ENZYMES AND SYSTEMS - The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. | 2017-11-09 |
20170321199 | ALICYCLOBACILLUS VARIANTS AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2017-11-09 |
20170321200 | Polypeptides Having Endoglucanase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2017-11-09 |
20170321201 | ENZYME-INHIBITOR COMPLEXES - The present invention concerns a method for selectively activating a thermostable hydrolase at a temperature above T1. The present invention provides compositions comprising a thermostable hydrolase and a temperature sensitive inhibitor, wherein said thermostable hydrolase and said temperature sensitive inhibitor form a hydrolase-inhibitor complex at a temperature below T1, but which dissociates at a temperature of about T1. The present invention also relates to uses of said compositions, and a method for preparing said compositions. | 2017-11-09 |
20170321202 | PENICILLIN-G ACYLASES - The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes. | 2017-11-09 |
20170321203 | METHODS FOR EXTRACTING AND PURIFYING NON-DENATURED PROTEINS - Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and purifying proteins that denature at low temperature. | 2017-11-09 |
20170321204 | METHODS FOR EXTRACTING AND PURIFYING NON-DENATURED PROTEINS - Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and purifying proteins that denature at low temperature. | 2017-11-09 |
20170321205 | UBIQUITIN VARIANT MODULATORS OF SCF E3 LIGASES AND THEIR USES - The invention provides ubiquitin variants that specifically bind to SCF E3 ligases, and use of these variants to modulate the activity of SCF E3 ligases. | 2017-11-09 |
20170321206 | INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF HISTIDYL-TRNA SYNTHETASES - Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | 2017-11-09 |
20170321207 | Device and a Method for Immobilization of Proteins, Enzymes or Cells - Provided herein are a device and a method for preparation of immobilized proteins, enzymes or cells on a carrier to achieve the industrial batch production of the immobilized proteins, enzymes or cells. | 2017-11-09 |
20170321208 | THERAPEUTIC CELL WASHING, CONCENTRATION, AND SEPARATION UTILIZING ACOUSTOPHORESIS - Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters. | 2017-11-09 |
20170321209 | METHOD FOR ISOLATING DNA - The present invention provides a method for the isolation of nucleic acid from microbial cells in an environmental sample. The method includes preparing a suspension of the environmental sample, lysing the suspended sample with a buffered solution, adding sodium dodecylsulfate solution to the lysed suspended sample, carrying out solvent extraction and separation to obtain an aqueous phase, reacting the aqueous phase with solvents to generate an insoluble precipitate containing nucleic acid, and isolating the nucleic acid therefrom, thereby releasing high molecular weight nucleic acid pellets from the cells. | 2017-11-09 |
20170321210 | METHOD FOR MODIFYING GENOME SEQUENCE TO INTRODUCE SPECIFIC MUTATION TO TARGETED DNA SEQUENCE BY BASE-REMOVAL REACTION, AND MOLECULAR COMPLEX USED THEREIN - The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site. | 2017-11-09 |
20170321211 | Whole Genome Mapping by DNA Sequencing With Linked-Paired-End Library - The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme, or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments, and methods of de novo whole genome mapping. Thus, the methods of this invention allow establishing sequence contiguity across the whole genome, and achieving high-quality, low-cost de novo assembly of complex genomes. | 2017-11-09 |
20170321212 | SYSTEM FOR ISOLATING DNA MOLECULES - Systems and methods for isolating DNA molecules that can include the steps of: providing a transposon mutant collection, the transposon mutant collection being stored in a plurality of wells; dispatching aliquots from each well in the transposon mutant collection to a set of pools in a combinatorial pooling array that uses pool address coordinates, the aliquots being dispatched to the set of pools based on a location of the aliquots within the transposon mutant collection; constructing an amplicon library, the amplicon library including a sequencing dataset; parsing the sequencing dataset to a set of putative transposon insertion locations and pool address coordinates; calculating a likelihood for each location and pool address coordinates within the set of putative transposon insertion locations and pool address coordinates using a Bayesian inference algorithm informed by internal self-consistency; and generating a progenitor collection catalog based on location and pool address coordinates verified in the calculating step. | 2017-11-09 |
20170321213 | Compositions and Methods for Inhibiting Expression of Transthyretin - The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR. | 2017-11-09 |
20170321214 | DEAD GUIDES FOR CRISPR TRANSCRIPTION FACTORS - The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems. | 2017-11-09 |
20170321215 | ALBUMIN PRODUCTION AND CELL PROLIFERATION - The present invention provides short activating RNA molecules which up-regulate albumin production. The present invention also provides methods of up-regulating albumin production, such methods involving the use of short activating RNA molecules capable of increasing the expression of albumin. The present invention also provides the use of the short activating RNA molecules in therapy, such as treating or preventing a hyperproliferative disorder and/or a disorder characterised by hypoalbuminemia. | 2017-11-09 |
20170321216 | MODULATION OF AGPAT5 EXPRESSION - Provided herein are methods, compounds, and compositions for reducing expression of an AGPAT | 2017-11-09 |
20170321217 | ANTISENSE OLIGONUCLEOTIDE FOR SPLICING ADJUSTMENT OF MUTANT DOPA DECARBOXYLASE GENE AND USING METHOD THEREOF - This present invention discloses an antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene which is complementary to SEQ ID NO: 1. This antisense oligonucleotide can modulate alternative splicing site of mutant dopa decarboxylase gene. It is helpful to research and develop drug to treat AADC deficiency symptom. This present invention also discloses a method to use said antisense oligonucleotide in vitro. | 2017-11-09 |
20170321218 | FACTOR XIA-SPECIFIC APTAMERS - The present disclosure concerns aptamers of formula (I) capable of specifically binding to Factor XIa. The aptamers can be used to prevent, treat or alleviate the symptoms of thrombosis. The aptamers can also be used to detect Factor XIa in a sample and/or purify Factor XIa from a sample. The aptamers can further be used to identity putative therapeutic agents for the prevention, treatment or alleviation of symptoms associated with thrombosis. | 2017-11-09 |
20170321219 | OLIGONUCLEOTIDE COMPOSITIONS WITH ENHANCED EFFICIENCY - The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell. | 2017-11-09 |
20170321220 | PRESENTATION OF BIOACTIVE PROTEINS - The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (Dec) protein along with a polynucleotide comprising the nucleic acid sequence of the fusion protein and a vector comprising the polynucleotide. Additionally, the invention provides a composition comprising the fusion protein and a virus-like particle (VLP), and a method of treating a disease in a mammal comprising administering a therapeutically effective amount of the composition to the mammal. The invention also provides a method of vaccinating against a disease comprising administering a composition comprising the fusion protein and a VLP encapsulating a protein. | 2017-11-09 |
20170321221 | BIOPHARMACEUTICAL PRODUCTION METHOD - The present invention resides in a method for the manufacture of a disulphide-requiring biopharmaceutical having an element of at least tertiary structure using wild type | 2017-11-09 |
20170321222 | YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR - Disclosed are yeast cells expressing TAR DNA-binding protein 43 (TDP-43) and methods of screening yeast cells to identify compounds that prevent or suppress TDP-43-induced toxicity, compounds that inhibit the formation or maintenance of cytoplasmic inclusions of TDP-43, genetic suppressors or enhancers of TDP-43-induced toxicity, and genetic suppressors or enhancers of the formation or maintenance of cytoplasmic inclusions of TDP-43. Compounds identified by such screens can be used to treat or prevent TDP-43 proteinopathies such as frontotemporal lobar degeneration or amyotrophic lateral sclerosis. | 2017-11-09 |
20170321223 | NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN MODIFYING PLANT METABOLISM - Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the disclosure provides a transcription factor that negatively regulates alkaloid biosynthesis, such as nicotine biosynthesis. | 2017-11-09 |
20170321224 | Modified Sendai Virus Vaccine and Imaging Vector - The present invention relates to a Sendai virus or recombinant Sendai virus vector. In particular the present invention provides methods, vectors, formulations, compositions, and kits for a modified Enders strain Sendai viral vector. An immunogenic vector can be used in any in vitro or in vivo system. Moreover, some embodiments include vectors for imaging virus growth, location and transmission. | 2017-11-09 |
20170321225 | METHODS, SYSTEMS, AND COMPOSITIONS RELATING TO MiRNA-146a - Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, exosomes comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, diseases, or injuries in mammals, including in human beings. | 2017-11-09 |
20170321226 | CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING - Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used. | 2017-11-09 |
20170321227 | Plant Activator Composition - A plant activator composition increases the concentration of terpenes a terpinoids in aromatic plant oils, and hence resulting in an increased concentration of terpene and terpinoids in the harvested dried plant or fruit. The composition contains one of more bio-active compounds that are optionally extracted from plants selected from one or more of the group consisting of mango, citrus (including grapefruit), | 2017-11-09 |
20170321228 | Method for Enhancing Microbial Methane Produciton - A process for revitalization of the coal deposit for enhanced microbial gas production by exposing coal deposit to air oxidation. Water is removed from coal beds and stored. The coal is exposed to hydrogen peroxide for providing oxygen-rich organic molecules that are more readily biodegraded. Oxidation and drying out of coal produces additional cracks within the coal matrix to allow microbes greater access to the overall coal matrix. The coal is reinjected with emulsified oil and inorganic nutrients by transporting produced water from the storage sites to the reinjection wells. Produced water is mixed with oil and inorganic nutrients in a holding tank. The reinjection water containing nutrients and oil is then injected into the coal under pressure. The mixture presence of the oil speeds up cell division of bacteria and methanogens in the coal and create microbial biomass sufficient to accelerate biomethanogenesis of the coal. | 2017-11-09 |
20170321229 | Alkenol Dehydratase Variants - Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol. | 2017-11-09 |
20170321230 | Diterpene Synthases and Method for Producing Diterpenoids - Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins, vectors, cells, transgenic organisms, uses, compositions, methods, processes, and kits thereof. | 2017-11-09 |
20170321231 | Surfactant-Improved Simultaneous Saccharification and Co-Fermentation Method for Lignocellulose - A surfactant-improved simultaneous saccharification and co-fermentation method for lignocelluloses in which a pretreated lignocellulose substrate is directly subjected to surfactant-improved simultaneous saccharification and co-fermentation without any detoxification by adding a surfactant, and the surfactant may be selectively added before or after pre-enzymatic hydrolysis, having economic, effective and feasible application prospects in reducing the loss of glucose, simplifying the production process, reducing equipment investment, reducing water consumption, improving ethanol production and reducing the total cost of the ethanol production process. | 2017-11-09 |
20170321232 | CARBON CAPTURE IN FERMENTATION - The invention relates to a method for producing products by microbial fermentation. The method comprises first converting a feed stream containing methane to a gaseous substrate comprising CO, of the invention include converting CO H | 2017-11-09 |
20170321233 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino acids. | 2017-11-09 |
20170321234 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL - The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | 2017-11-09 |
20170321235 | TRANSFORMED FUNGUS HAVING ENHANCED ERGOTHIONEINE PRODUCTIVITY AND METHOD FOR PRODUCING ERGOTHIONEINE - The purpose of the present invention is to provide an organism having an ergothioneine productivity that is capable of easily producing ergothioneine within a short period of time at a high yield, as compared with a conventional technology, and, therefore, enables ergothioneine production on an industrial scale. This purpose can be achieved by a transformed fungus into which a gene encoding enzyme (1) or genes encoding enzymes (1) and (2) have been inserted and in which the inserted gene(s) are overexpressed. (1) an enzyme catalyzing a reaction of synthesizing hercynyl cysteine sulfoxide from histidine and cysteine in the presence of S-adenosyl methionine, iron (II) and oxygen. (2) An enzyme catalyzing a reaction of synthesizing ergothioneine from hercynyl cysteine sulfoxide using pyridoxal 5′-phosphate as a coenzyme. | 2017-11-09 |
20170321236 | METHOD FOR THE MANUFACTURE OF BIO-PRODUCTS WITH A MODIFIED SUGAR PROFILE - The invention relates to a method for the production of a solid bio-product wherein at least 80% of the original indigestible oligosaccharide (raffmose, stachyose and verbascose) content has been degraded into digestible mono- and disaccharides, comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and optionally polysaccharides and further comprising proteinaceous plant parts, water and one or more enzyme preparations containing .alpha.-galactosidase(s); 2) reacting the mixture resulting from step (1) under continuous mixing and under conditions where the water content in the initial mixture does not exceed 65% by weight, for 0.15-36 hours at a temperature of about 20-65° C.; 3) incubating the reacted mixture from step (2) at a temperature and in a time period which inactivate said α-galactosidase(s), as well as solid bio-products obtainable by such method. The invention further relates to uses of the bio-product and a food, a feed, a cosmetic or pharmaceutical product or a nutritional supplement containing the solid bio-product. | 2017-11-09 |
20170321237 | Improved Production of Glucose Syrups - The present invention relates to a method of making glucose syrup from liquefied starch, and to compositions useful therein. | 2017-11-09 |
20170321238 | Recombinant Production of Steviol Glycosides - Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements. | 2017-11-09 |
20170321239 | CELL-FREE PROTEIN EXPRESSION USING ROLLING CIRCLE AMPLIFICATION PRODUCT - Methods for in vitro transcription and translation from an RCA product are provided. The methods comprise providing a double-stranded RCA product, wherein the double-stranded RCA product consists essentially of tandem repeats of a minimalistic expression sequence. The methods further comprise expressing a protein from the double-stranded RCA product in a cell-free expression system. | 2017-11-09 |
20170321240 | GLYCOSYLATION MUTANTS FOR PRODUCING GALACTOSE-FREE AND FUCOSE-FREE POLYPEPTIDES - We describe a method of reducing batch-to-batch variation or increasing homogeneity between batches in the production of a recombinantly expressed polypeptide. The method comprises expressing the polypeptide in a Chinese hamster ovary (CHO) cell comprising reduced UDP-galactose transporter activity compared to a wild-type CHO cell. In some embodiments, the CHO cell further comprises reduced GDP-fucose transporter activity. | 2017-11-09 |
20170321241 | 21-Hydroxylation of Steroids - Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells. | 2017-11-09 |
20170321242 | TRANSFORMED CELLS THAT FERMENT PENTOSE SUGARS AND METHODS OF THEIR USE - The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolized by the host cell. Thus, the host cell is capable of growth on xylose as carbon source. The host cell preferably is a eukaryotic microorganism such as a yeast or a filamentous fungus. The invention further relates to processes for the production of fermentation products such as ethanol, in which a host cell of the invention uses xylose for growth and for the production of the fermentation product. The invention further relates to nucleic acid sequences encoding eukaryotic xylose isomerases and xylulose kinases as obtainable from anaerobic fungi. | 2017-11-09 |
20170321243 | IMPROVED METHOD FOR DETERMINATION OF MICROORGANISMS - The present invention relates to determination of the microorganism content in material comprising cellulose within the pulp and paper industry. The material comprising cellulose is enzymatically pretreated and microorganisms are determined using PCR based technology. | 2017-11-09 |
20170321244 | SYSTEMS AND METHODS FOR STERILITY TESTING OF RADIONUCLIDE GENERATOR COLUMN ASSEMBLIES - A method includes sterilizing a column assembly including a column having a parent radionuclide contained therein with a sterilizer. The method further includes transferring the column assembly from the sterilizer to a first clean room environment, transferring the column assembly from the first clean room environment to a second clean room environment, and collecting a sterility test sample from the column assembly within the second clean room environment. | 2017-11-09 |
20170321245 | Flash and Glow 1,2-Dioxetanes - Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these compounds. | 2017-11-09 |
20170321246 | QUANTIFICATION OF NON-REDUCING END GLYCAN RESIDUAL COMPOUNDS FOR DETERMINING THE PRESENCE, IDENTITY, OR SEVERITY OF A DISEASE OR CONDITION - Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation. | 2017-11-09 |
20170321247 | CANCER MARKER AND CANCER DETERMINATION METHOD - The invention relates to a cancer marker, consisting of a portion of or all of the nucleotide sequence represented by SEQ ID NO: 1 in a FOXB2 gene derived from a cell, and being continuous nucleotide sequences comprising at least the nucleotide sequence represented by SEQ ID NO: 2 or 3, wherein 30% or more of cytosines of the -CG- sequences present in said nucleotide sequence are methylated, and method for determining canceration of a cell on the basis of methylation ratio, wherein said methylation ratio is measured by a bisulfate reaction for a portion of or all of cytosines of the -CG- sequences present in the nucleotide sequence represented by SEQ ID NO: 1 in a FOXB2 gene derived from a cell. | 2017-11-09 |
20170321248 | METHODS AND PRODUCTS FOR QUANTIFYING RNA TRANSCRIPT VARIANTS - The present invention relates to the field of transcriptomics and provides a method for the controlled identification and/or quantification of transcript variants in samples, comprising providing a reference set of artificial polynucleic acid molecules simulating transcript variants and adding said reference set as external control to samples comprising transcript variants. The present invention further provides such a reference set, as well as a method to produce such a reference set. | 2017-11-09 |