46th week of 2009 patent applcation highlights part 36 |
Patent application number | Title | Published |
20090280432 | PHOTOSENSITIVE SHEETS AND METHOD AND APPARATUS FOR MANUFACTURING THE SAME - Photosensitive film can be protected in stacking photosensitive sheets and a sheet can be separated one at a time in a state where photosensitive sheets are stacked, ensuring its taking out. An apparatus for manufacturing PS plates, which is adapted to provide photosensitive film on one side of both surfaces of the web, is provided with a coating device for applying coating liquid to form resin film on the other side of the web, a drying device for drying and solidifying the coating liquid applied, and a concave and convex portions forming device for forming concave and convex portions on the surface of the resin film. | 2009-11-12 |
20090280433 | RADIATION-SENSITIVE COMPOSITION AND PROCESS FOR PRODUCING LOW-MOLECULAR COMPOUND FOR USE THEREIN - A radiation-sensitive composition contains (A) a low-molecular-weight compound having one or more acid-dissociable groups which decompose by the action of an acid to enhance solubility in an alkaline developing solution and one or more radiation-sensitive acid-generating groups which generate an acid upon application of an active ray or radiation per molecule, and having a polystyrene-reduced number-average molecular weight (Mn) measured by gel permeation chromatography (GPC) of 500 to 4,000, and (B) a solvent. | 2009-11-12 |
20090280434 | RESIST COMPOSITION AND PATTERNING PROCESS - A copolymer of an alkali-soluble (α-trifluoromethyl)-acrylate and a norbornene derivative is useful as an additive to a resist composition. When processed by immersion lithography, the resist composition exhibits excellent water repellency and water slip and forms a pattern with few development defects. | 2009-11-12 |
20090280435 | Antireflective coating composition - The invention relates to an antireflective coating composition comprising a polymer, a crosslinker and a thermal acid generator, where the polymer comprises at least one unit of structure (1), at least one unit of structure (2) and at least one structure of structure (3), | 2009-11-12 |
20090280436 | Immersion system, exposure apparatus, exposing method, and device fabricating method - An immersion system is used in an immersion exposure, wherein a substrate is exposed with an exposure light through an optical member and a liquid, and that fills an optical path of the exposure light between the optical member and the substrate with the liquid. The immersion system comprises: a first member, which is disposed around the optical path of the exposure light and has a first surface that faces in a first direction; a second member that has a liquid recovery port, which is disposed on the outer side of the first surface with respect to the optical path of the exposure light; a first drive apparatus that is capable of moving the first member parallel to the first direction; and a second drive apparatus that is capable of moving the second member parallel to the first direction independently of the first member; wherein, a space between the first surface and a front surface of an object can hold the liquid; and a liquid between the liquid recovery port and the front surface of the object is recovered via the liquid recovery port. | 2009-11-12 |
20090280437 | PROJECTION EXPOSURE METHODS AND SYSTEMS - Projection exposure methods, systems, sub-systems and components are disclosed. Methods can include performing a first exposure to image a first sub-pattern of the pattern, where the first sub-pattern includes a plurality of first features extending in a first direction and spaced apart essentially periodically at a predominant periodicity length P in a second direction perpendicular to the first direction. The first exposure can be performed using a multipolar illumination mode that includes at least one substantially dipolar intensity distribution having two illumination poles positioned on a pole orientation axis substantially parallel to the second direction and spaced apart from each other. The poles of the dipolar intensity distribution can each have an azimuthal width defined by a pole angle θ, and a pole area A | 2009-11-12 |
20090280438 | METHOD OF FORMING PATTERN - A method of forming a pattern including: forming an underlayer film on a support using an underlayer film-forming material, forming a hard mask on the underlayer film using a silicon-based hard mask-forming material, forming a first resist film by applying a chemically amplified positive resist composition to the hard mask, forming a first resist pattern by selectively exposing the first resist film through a first mask pattern and then performing developing, forming a first pattern by etching the hard mask using the first resist pattern as a mask, forming a second resist film by applying a chemically amplified positive silicon-based resist composition to the first pattern and the underlayer film, forming a second resist pattern by selectively exposing the second resist film through a second mask pattern and then performing developing, and forming a second pattern by etching the underlayer film using the first pattern and the second resist pattern as a mask. | 2009-11-12 |
20090280439 | EXPOSURE APPARATUS, EXPOSURE METHOD, AND DEVICE MANUFACTURING METHOD - A light branching unit and a reflecting mirror are fixed to a barrel in a state where the distance between the members is constantly maintained. And, a laser beam from a light source is guided to the light branching unit via an optical fiber, separated to a measurement beam and a reference beam by a beam splitter, and a synthesized light of the measurement beam and the reference beam that reciprocate between the light branching unit and the reflecting mirror in the liquid is then guided to a photodetection system via the optical fiber. And, the measurement beam and the reference beam are made to interfere inside this photodetection system, and a change of an optical path length of the measurement beam is measured based on a photoelectric conversion signal of the interference light. Accordingly, change of a refractive index of the liquid can be optically measured. | 2009-11-12 |
20090280440 | SURFACE TREATING AGENT FOR RESIST-PATTERN, AND PATTERN-FORMING METHOD USING SAME - A surface treating agent for resist pattern, characterized by containing not only a chemical species having a functional group capable of chemical adsorption to resist pattern and a polymerizable group but also a solvent. | 2009-11-12 |
20090280441 | EXPOSURE METHOD, EXPOSURE DEVICE, AND MICRO DEVICE MANUFACTURING METHOD - An exposure device includes: a light source (LS) which emits a pulse light; and a variable shaped mask ( | 2009-11-12 |
20090280442 | Device And Method Of Combusting Solid Fuel With Oxygen - The present invention is a method of combustion of a solid fuel stream with oxygen. The present invention includes introducing a first stream, comprising a first portion of substantially pure oxygen, into a first conduit. The present invention includes introducing a second stream, comprising a solid fuel stream and a conveying media, into a second conduit, wherein the second conduit is concentric with, and surrounding, the first conduit. The present invention includes introducing a third stream, comprising a second portion of substantially pure oxygen, into a third conduit, wherein the third conduit is concentric with, and surrounding, the first conduit and the second conduit. The present invention includes igniting the first stream, the second stream, and the third stream as they exit the first conduit, the second conduit and the third conduit, in such a way as to create a flame. The present invention includes introducing a fourth stream, comprising a first portion of ballast gas, into a fourth conduit, wherein the fourth conduit is concentric with, and surrounding, the first conduit, the second conduit, and the third conduit. The present invention includes introducing a fifth stream, comprising a second portion of ballast gas, into a fifth conduit, wherein the fifth conduit is concentric with, and surrounding, the first conduit, the second conduit, the third conduit and the fourth conduit. | 2009-11-12 |
20090280443 | BURNER WITH LANCE - The present invention relates to a burner for a combustion chamber of a gas turbine plant. The burner includes a lance for introducing gaseous fuel into the burner. A shaft of the lance has at least one nozzle for introducing gaseous fuel into the burner. A main injection direction of the respective nozzle is oriented onto a portion of a burner wall. An introduction device for a diverting fluid is provided, which is designed for introducing a diverting fluid counteracting an impingement of the fuel flow on the burner wall. | 2009-11-12 |
20090280444 | Highly Radiative Burner and Combustion Process - An oxy-fuel burner that co-fires liquid fuel and gaseous fuel to create a more luminous flame. The characteristics of a liquid fuel spray and the gaseous fuel and primary oxidant gas flows, as well as the geometry of the burner is adapted to shroud the liquid fuel from the primary oxidant until it exits a precombustor and to prevent the liquid fuel from contacting the walls of the precombustor. | 2009-11-12 |
20090280445 | METHOD OF CONTROLLING GAS TYPE CLOTHES DRYER - Disclosed herein is a method of controlling a gas type clothes dryer. The method control the dryer to continuously detect condition of a flame sensor even after ignition of the dryer, thereby preventing a drying operation from being performed when a flame has been extinguished due to insufficient gas supply caused by failure of a gas valve. | 2009-11-12 |
20090280446 | Candle holder with self-extinguishing flame device - A self-extinguishing candle flame apparatus is provided, the apparatus comprises: a base; a post having opposing ends, at least a portion of the first end of the post is attached to the base; a pliable wax coil having opposing ends, at least a portion of the wax coil being situated upon the base, the wax coil forming a candle, the candle comprising an elongated wick being situated within the wax coil, at least a portion of the wick protruding from one end of the wax coil; and a self extinguishing device comprising at least two sections that form a clamp, at least a portion of each of the two sections being attached to a spring, each of the sections having opposing ends, the first end of each of the two sections comprises a head and the second end of each of the two sections comprises an arm, the first and second sections being connected at a joint, during a closed position, each of the heads contact one another and forms an extended rim with side walls and an aperture therebetween designed to receive a portion of the wax coil, the extended rim with the side walls forming a height that when the candle burns down within the aperture, the flame is extinguished by operation of oxygen deprivation. | 2009-11-12 |
20090280447 | BACKPACKING STOVE - A burning appliance having a burner assembly including a burner for providing combustion is disclosed. The appliance includes a fuel tip for supplying fuel to the burner assembly and a fuel control and cleaning assembly cooperating with the fuel tip to permit control of fuel supplied to the burner and cleaning of the fuel tip while the appliance is in operation. The cleaning assembly may be formed on the appliance itself and may incorporate a cleaning element, a cleaning element control mechanism and a heat dissipating interface positioned with respect to the cleaning element and the cleaning element control mechanism such that a user may control the cleaning element with the cleaning element control mechanism without the use of gloves or other protective equipment while the appliance is in operation. | 2009-11-12 |
20090280448 | MULTIPLE GAS PILOT BURNER - A multiple gas pilot burner assembly for a household heating appliance. The pilot burner includes an injector having a first conduit for receiving a flow of a first combustible fluid, a second conduit for receiving a flow of a second combustible fluid and a third conduit connected to and in fluid communication with the first and second conduits which is configured to receive the flow of the first combustible fluid from the first conduit or the flow of the second combustible fluid from the second conduit. A single nozzle at the outlet of the third conduit is provided for supplying a pilot flame. The assembly also includes a single flame igniter positioned to cause an ignition of the pilot flame at the nozzle and also a single thermocouple positioned to be heated by the pilot flame and to generate an electrical current when heated. | 2009-11-12 |
20090280449 | Apparatus and method for heat treatment - A furnace for heat treating components, especially relatively long components such as main shafts of gas turbine engines, comprises means for mounting a number of components vertically and conveying them repeatedly around a circular path surrounding one or more heating elements, while simultaneously rotating the components about their vertical axes. This allows uniform heat treatment of the components, even when long treatment times are needed. Loading and unloading chambers adjacent to the main chamber permit automated loading and unloading of components without disturbing the environment within the main chamber. | 2009-11-12 |
20090280450 | PRE-FORMED HARD-SHELL ATTACHMENT DEVICES FOR DENTAL APPLIANCES - A dental appliance attachment device includes a rigid, substantially non-deformable shell having a hollow interior and an exterior surface defining an external configuration of the attachment device. A curable, adhesive filler is provided in the interior of the shell. The resin is adhesively bondable to the tooth surface upon being cured so as to semi-permanently bond both the shell and the filler to the surface of the tooth. The shell, with the uncured filler material, is placed on the tooth surface at a desired site with a placement device, which may be either a placement template or an elongate placement implement. The filled shell is detachably fixed to the placement device, so that when the filled shell is placed on the tooth surface, the placement device may be removed before the filler is cured to bond the attachment device to the tooth surface. | 2009-11-12 |
20090280451 | DENTAL ARTICULATOR REFERENCE OBJECT - A dental model articulator of the type that has separable complementary articulation members is connected to a registration object having compatible complementary articulation members. The dental arches of each dental model articulator half is scanned with the reference object to give the axis of the articulator model. This facilitates generating a virtual dental model. | 2009-11-12 |
20090280452 | SINUS BUR HAVING AN EDGE WITHOUT SHARP POINTS - A dental bur used for boring pilot holes in the maxilla during endosseous dental implant surgery comprised of a rigid cylindrical body with a distal flat end having cutting blades and rounded edges. By using a bur having a flat cutting end face with rounded edges and not points, the pilot hole depth can be closer to the sinus cavity wall reducing the force required to infracture the remaining bond. | 2009-11-12 |
20090280453 | Device for a dental treatment - The device for a dental treatment using at least one retention pin to be inserted into the root canal of teeth, and a container, having at least one sac bore for receiving the retention pin is characterized in that the retention pin is equipped with a coating, and is connected to a retainer at its one end in a releasable manner, which is removably placed into the sac bore, or inserted into the same such that the retention pin is retained centered at a distance of the walls of the sac bore, and in that the sac bore is sterilized with the retention pin and hermetically sealed. | 2009-11-12 |
20090280454 | Dental Implant with Bone and Gingival Tissue Preservation Collar - Preserving the perigingival site from repeated disturbance by offering a continuous transition through the soft tissue as the external aspect of a dental implant fixture without partitions or gaps. The soft tissue is protected from repeated insertions and removal of an abutment resulting in less bone loss and gingival recession by an integral concave collar while allowing an ample volume of interproximal soft tissue. | 2009-11-12 |
20090280455 | INTERACTIVE DENTAL RESTORATIVE NETWORK - The invention relates to a computer readable medium that includes one or more programs for carrying out a method for restoration of a patient's tooth. The method includes the steps of generating an electronic image of a patient's tooth; providing a preliminary treatment plan for addressing the dental needs of the patient; and forwarding the electronic image and preliminary treatment plan to a dental laboratory so that technician can evaluate the image and treatment plan and in a manner such that the technician and dentist can review and discuss the preliminary treatment plan. | 2009-11-12 |
20090280456 | Method and system for automatically generating questions for a programming language - The present invention provides a method, system and computer program product for generating a family of questions for a programming language. Generating the family of questions includes the generation of various questions from a particular compilable code, and the corresponding options for the questions. The options include various correct and incorrect options for the questions. | 2009-11-12 |
20090280457 | CARD GAME FOR LEARNING AND PRACTICING FOREIGN LANGUAGES - A card game played with a deck of playing cards in a native language that are organized in thematic suits. Each player aims at having as many full suits as possible. Each player in turn asks other players for cards out of suits held by the player. The thematic suits comprise playing cards with expressions in at least one foreign language. Playing the game promotes the knowledge of the players of the foreign languages. | 2009-11-12 |
20090280458 | Combination teaching and learning kit and method - A combination teaching and learning kit is provided. Such combination teaching and learning kit includes a chart member for at least one of free standing and attachment to a wall, a table, and an item of furniture. A plurality of card members having predetermined indicia disposed on at least first predetermined side thereof and a securing mechanism disposed on at least an opposite second predetermined side thereof for releasably attaching the card members to such chart member. | 2009-11-12 |
20090280459 | LOW CONTRAST TRAINING - Methods and equipment to improve the visual ability of a subject during athletic activities are provided. One such method includes configuring a sporting object to visually approximate the appearance of a background or configuring a background to visually approximate the appearance of a sporting object. A subject may then train using the sporting object visually in front of the low contrast background. A background where the visual appearance of the background comprises at least one depiction of the sporting object may be used. A subject may then train using the sporting object visually in front of the background. | 2009-11-12 |
20090280460 | Systems and methods for providing personalized interactive educational displays - Systems and methods are provided for capturing student interaction data, wherein the student interaction data has one or more data elements. A student's personalized interactive educational display is configured based at least in part on the captured student interaction data, and then displayed. The systems and methods provide access to resources of an educational institution from the student's configured personalized interactive educational display based at least in part on the captured student interaction data. Directed surveys may be electronically provided to the student based at least in part on the captured student interaction data. The personalized interactive educational display provides controlled access of educational services or commerce services. The personalized interactive educational display electronically provide access to lecture notes, on-line discussion groups, educational resource materials, or course materials. Additional resource materials may also at least in part on the captured student interaction data or academic performance of the student. | 2009-11-12 |
20090280461 | Interactive Book with Detection of Lifted Flaps - An interactive system for providing multimedia data in response to interaction with lift-the-flap elements. The system may include a housing which forms a substantially planar surface configured to support at least one printed media sheet. The printed sheet may include at least one lift-the-flap element. The system may further include a playback device configured to provide multimedia data relating to the lift-the-flap element. The system may include a detector which is configured to detect a position of the lift-the-flap element and provide position information. The system may further include a processing unit configured to cause playback of the multimedia data via the playback device based on the position information provided by the detector. | 2009-11-12 |
20090280462 | Systems and methods for goal attainment in post-graduation activities - Systems and methods are provided for electronically correlating pre-graduation student interactions with one or more post-graduation outcomes. The systems and methods comprise capturing pre-graduation student interaction data and capturing post-graduation student data. The systems and methods determine one or more post-graduation outcomes from the captured post-graduation student data, and correlate the pre-graduation student interaction data elements with the one or more post-graduation student outcomes. The systems and methods determine which captured pre-graduation student interaction data elements and/or post-graduation student data elements have increased correlation with the one or more post-graduation outcomes. Factor analysis may be used to determine which pre-graduation and/or post-graduation captured data elements have an increased correlation with the post-graduation outcomes. | 2009-11-12 |
20090280463 | Systems and methods for goal attainment in achievement of learning - Systems and methods are provided for measuring how well a student achieves learning outcomes. A student identification card or an electronic device may be associated with a student that may contain student data or other student information. The card or device may be swiped, read by a proximity reader, engaged in an interchange of information based on a received request, or be subject to any other registration by the system. The registered use of the card or device based on student interactions may be associated with particular student outcomes. Goal attainment may be determined on a per student basis, with each student having corresponding student data stored in a database. The system may be configured to utilize factor analysis to determine which interactive student data characteristics, including those determined by card or device registration by the system, have increased correlation with attaining the predefined goal of achieving one or more learning outcomes. | 2009-11-12 |
20090280464 | SYSTEM AND METHOD FOR PROVIDING EDUCATIONAL CONTENT THROUGH GAMING OVER A NETWORK - A method of distributing educational content over a network is disclosed. Educational content is divided into topics and the topics are split into smaller educational units. Professionals reviewing the material for accreditation purposes choose particular units to study and are subject to minimum and maximum time parameters. The partitioning of educational topics allows advertisers to deliver episodic advertising over an extended time period. | 2009-11-12 |
20090280465 | SYSTEM FOR THE NORMALIZATION OF SCHOOL PERFORMANCE STATISTICS - A method and system is provided to directly compare school districts and individual schools across state lines, and the geographic areas served by those schools (counties, municipalities, zip codes, neighborhoods) based on their reported standardized test scores despite the fact that each state has prepared their own version of standardized tests to benchmark the performance of their students. While standardized tests, such as the No Child Left Behind (NCLB) test, can provide a meaningful comparison between any students and schools that were administered the same test, since the tests are different state-to-state a comparison on this basis is generally inaccurate and unreliable. To normalize the local standardized test results based on the differences in tests in different localities, an additional factor is employed as a modifier of the NCLB test results resulting in a normalized comparison. | 2009-11-12 |
20090280466 | LEARNING ASSESSMENT AND PROGRAMMATIC REMEDIATION - Learning content may be provided to a user where the learning content may contain learning objectives. A response to the learning content may be received. The response may be analyzed by determining whether the response was the proper response to the learning objectives. If the response was a proper response, less questions on the learning objective may be presented in the future and the if response was an improper response, additional questions on the learning objective may be presented in the future. | 2009-11-12 |
20090280467 | PLATFORM AND METHOD FOR AUTOMATED PHONE EDUCATION - A platform and method for providing telephonic education. The platform utilizes a telephone-server connection to provide automated registration, payment, course materials, and sending of a notice of completion. | 2009-11-12 |
20090280468 | Systems and methods for providing early warning of student absence - Systems and methods are provided for electronically providing notification that a student has not been engaged with an educational institution for a predefined period of time. Student interaction data may be captured, wherein the student interaction data has one or more data elements and relates to use of the one or more facilities, services, or facilities and services of the educational institution. The systems and methods may determine an absence of student interaction data for the predefined period of time, and provide providing a notification to a predefined authority based on the determined absence of student interaction. The systems and methods may further notify predefined authority for prolonged absence of a visiting student, or absence of student interaction data related to dining facilities of an educational institution. The systems and methods may monitor student performance and correlate the absence of student interaction data with academic performance. | 2009-11-12 |
20090280469 | CELL MASS CAPABLE OF SERVING AS A PRIMITIVE ORGAN-LIKE STRUCTURE COMPRISED OF A PLURALITY OF CELL TYPES OF SOMATIC ORIGIN - The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state. | 2009-11-12 |
20090280470 | EXTRACTION AND DIAGNOSTIC FLUID DEVICES, SYSTEMS AND METHODS OF USE - The present invention provides devices, systems and methods for RNA isolation from biological samples containing white blood cells, such as whole blood. The devices have a device body that includes a first chamber having a first membrane that selectively binds white blood cells, a second chamber having a second membrane that reversibly binds RNA and a plurality of ports that are removably attached to a reagent pack and waste receptacle via a valving system controlled by a control unit. | 2009-11-12 |
20090280471 | METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS - The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples. | 2009-11-12 |
20090280472 | Method for Detection of Antigens - The field of the invention relates generally to the detection of antigens, including, but not limited to, quantum dots (Qdots) and metal oxide nanoparticles. More specifically, the invention relates to the detection of antigens on a surface or in a source, which antigens include bacteria, viruses, and small proteins. In some embodiments, the invention can be used to detect biological warfare agents, such as anthrax and ricin. In some embodiments, the invention can be used for early detection of diseases in human and animals. The invention may utilize a swab-test and may further utilize a filtration process, such as with a syringe-disc. | 2009-11-12 |
20090280473 | Inhibition of membrane fusion proteins - Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the ability to inhibit infection by a virus having a class II viral fusion protein. Additionally provided herewith are aqueous-soluble proteins comprising a portion of a class II viral fusion protein comprising a Domain III of the viral fusion protein. | 2009-11-12 |
20090280474 | METHOD FOR DETECTING A VIRUS - This invention is related a method for increasing the sensitivity of detecting a viral target in a sample. The sensitivity may be increased by disrupting a complex comprising the target or by measuring the level of the target from a larger volume of the sample. | 2009-11-12 |
20090280475 | Droplet-based pyrosequencing - The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol. | 2009-11-12 |
20090280476 | Droplet-based affinity assay device and system - The present invention relates to a droplet-based affinity assay device and system. According to one embodiment, a droplet microactuator is provided and includes an antibody immobilized on a surface. According to another embodiment, a droplet microactuator is provided and includes a droplet on the droplet microactuator, the droplet comprising an antibody. | 2009-11-12 |
20090280477 | Turn Over Probes and Use Thereof for Nucleic Acid Detection - The invention provides turnover probes for use in a variety of detection assays, for example, nucleic acid detection assays. In addition, the invention provides assays, for example, nucleic acid detection assays, using such turnover probes. | 2009-11-12 |
20090280478 | GENE METHYLATION AND EXPRESSION - The invention provides a method of analyzing the methylation status of all or part of an entire genome. Moreover, the invention features methods of and reagents for characterizing biological cells containing DNA that is susceptible to methylation. Such methods include methods of diagnosing cancer, e.g., breast cancer. | 2009-11-12 |
20090280479 | USE OF FREE CIRCULATING DNA FOR DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER FUNDING - A method of detecting circulating DNA in a body fluid. The method comprises identifying a subject suffering from or at risk for developing cancer, obtaining a body fluid sample from the subject, and determining the sequence integrity of circulating DNA in the sample, wherein the circulating DNA is not purified from the sample. | 2009-11-12 |
20090280480 | Devices from Prion-Like Proteins - The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing in, for example, the production of nanoscale devices. | 2009-11-12 |
20090280481 | Enhanced Sequencing by Hybridization Using Pools of Probes - The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of pools of probes, as well as methods of generating pools of probes. | 2009-11-12 |
20090280482 | Novel nucleic acid sequences encoding adenylate kinases, alcohol dehydrogenases, ubiquitin proteases, lipases, adenylate cyclases, and GTPase activators - The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided. | 2009-11-12 |
20090280483 | Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors - The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods. | 2009-11-12 |
20090280484 | METHODS FOR GENE MAPPING AND HAPLOTYPING - The present invention is directed to methods for providing a definitive haplotype of a subject. The haplotype information generated by the methods described herein is more accurate than that provided by prior art methods that only give an inferred haplotype. Accordingly, in one aspect the present invention provides a method for determining a definitive haplotype of a subject the method including the steps of providing a substantially isolated haploid element from the subject, and obtaining nucleotide sequence information from the haploid element. Applicants propose that the use of a substantially isolated haploid element eliminates the problem of incorrect or misleading inferences concerning the phase of two or more loci within a haplotype, and allows for revelation of two or more participatory genes within a haplotype, uncomplicated by differences in modes of inheritance. The guarantee of strictly cis-phase associations is provided in the present methods by the use of a substantially isolated haploid element as starting material for sequence analysis. | 2009-11-12 |
20090280485 | Methods and Reagents for the Determination of Telomere Length in a Semi-Automatic Manner of Every Single Cell in a Immobilized Cell Population - The invention relates to methods and reagents for the determination of telomere length in tissue sections by the single cell telomeric mapping technique based on a fluorescent in situ hybridization step using a telomere-specific probe and an interpolation step using a standard curve correlating fluorescent intensity and telomere length obtained from a collection of cell lines of known telomere length. The invention further relates to methods for the identification of stem cell niches within tissues and for the identification of compounds capable of triggering stem cell mobilization using the telomere length as criteria for the identification of stem cells and which rely on the single cell telomeric mapping technique of the invention. | 2009-11-12 |
20090280487 | METHODS FOR PRODUCING OLFACTORY GPCRS - The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell under conditions suitable for production of the olfactory GPCR. Also provided is a macroglial cell containing a recombinant nucleic acid encoding an olfactory GPCR, methods of screening for modulators of olfactory GPCR activity, and a kit for producing an olfactory GPCR in a macroglial cell. The invention finds most use in research on flavors and fragrances, and, consequently, has a variety of research and industrial applications. | 2009-11-12 |
20090280488 | Prophylactic/therapeutic agent for neurodegenerative disease - To provide a prophylactic/therapeutic agent for neurodegenerative diseases (such as polyglutamine diseases), the agent containing an HMGB family protein or a derivative thereof, such as a protein according any one of (a) and (b) below:
| 2009-11-12 |
20090280489 | Ig genes specific oligonucleotides and uses thereof - The present invention provides oligonucleotides for detection of rearrangement of immunoglobulin genes for identifying clonality of cells, cancer cells, hypermutation in immunoglobulin gene, antibody isotype producing cell and/or assaying B cell repertoire in a sample. The oligonucleotides disclosed in the present invention are very specific to the immunoglobulin genes. | 2009-11-12 |
20090280490 | Expression Profile Algorithm and Test for Cancer Prognosis - The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm) that yields a numerical recurrence score, which indicates recurrence risk. | 2009-11-12 |
20090280491 | PREDICTING CANCER INVASIVENESS - Provided are methods of determining the likelihood of a human cancer being invasive. Also provided are methods of determining whether a lung adenocarcinoma is a bronchioloalveolar carcinoma (BAC). Additionally provided are methods of deciding a course of treatment for a patient with a cancer. | 2009-11-12 |
20090280492 | DIAGNOSIS OF FETAL ABNORMALITIES USING POLYMORPHISMS INCLUDING SHORT TANDEM REPEATS - The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample. | 2009-11-12 |
20090280493 | Methods and Compositions for the Prediction of Response to Trastuzumab Containing Chemotherapy Regimen in Malignant Neoplasia - The invention relates to methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of neoplastic disease. Neoplastic disease is often caused by chromosomal rearrangements which lead to over- or underexpression of the rearranged genes. The invention discloses genes which are overexpressed in neoplastic tissue and are useful as diagnostic markers and targets for treatment. Methods are disclosed for predicting, diagnosing and prognosing as well as preventing and treating neoplastic disease. | 2009-11-12 |
20090280494 | Method for the detection of cytosine methylations in immobilized DNA samples - A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to the surface is treated, preferably with a bisulfite, in such a way that cytosine is converted into a base that is different in its base pairing behavior in the DNA duplex, while 5-methylcytosine remains unchanged. Then the reagents that were used are removed in a washing step. Finally, selected segments of the immobilized DNA are amplified in a polymerase reaction and the amplified products are investigated with respect to their sequence. | 2009-11-12 |
20090280495 | ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 2009-11-12 |
20090280496 | NON-INVASIVE METHOD FOR DIAGNOSING FETAL CELLS AND CANCER CELLS - A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes. | 2009-11-12 |
20090280497 | Multiplex Detection Compositions, Methods, and Kits - The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex. | 2009-11-12 |
20090280498 | RAPID AND EFFICIENT CAPTURE OF DNA FROM SAMPLE WITHOUT USING CELL LYSING REAGENT - Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer. This method for preparing specimen samples is simple and quite rapid, and the released nucleic acids can be further treated in hybridization assays or amplification procedures. No surfactant or other cell lysing reagents are employed. The weakly basic polymers are water-soluble and cationic at acidic pH, but neutral in charge at basic pH. | 2009-11-12 |
20090280500 | Assay for generation of a lipid profile using fluorescence measurement - The present invention relates to a method of generating a lipid profile for a sample solution. The method comprising: a first step of determining the concentration of total lipoprotein in a first aliquot of the sample using fluorescence analysis; a second step of determining the concentration of total cholesterol in a second aliquot of the sample using fluorescence analysis; and optionally a third step of determining the concentration of HDL in a third aliquot of the sample using fluorescence analysis. The concentrations of the total lipoprotein, and of total cholesterol may be used to calculate other lipid components and thereby generate a lipid profile. The invention also concerns apparatus that may be used to perform the method of the invention. | 2009-11-12 |
20090280501 | A Method And A Kit For Diagnosing Type 2 Diabetes, Metabolic Syndrome, Sub Clinical Atherosclerosis, Myocardial Infarct, Stroke Or Clinical Manifestations Of Diabetes - A method and a kit for diagnosing or prognosing susceptibility to develop type 2 diabetes, the metabolic syndrome, sub clinical atherosclerosis, myocardial infarct, stroke or clinical manifestations of diabetes in a subject. The method comprises detecting and quantifying the amount of bound protein (s), (apoCIII, apoCI, apoA1 or apoE) on small dense low density lipoproteins (sdLDL) particles in a blood sample from said subject. | 2009-11-12 |
20090280502 | ANTI-2-O-DESULFATED ACHARAN SULFATE ANTIBODY AND ITS APPLICATION - An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate. | 2009-11-12 |
20090280503 | Method for detecting and treating skin disorders - The invention provides for methods of detecting and treating diseased tissue, particularly in skin diseases or disorders, such as psoriasis, scleroderma, eczema or atopic dermatitis tissue. The method involves administrating a composition comprising an antibody specific to the diseased tissue to a patient. After administration, the antibody in the composition binds to the exposed cell surface antigen (epitope) and allows the detection and/or disrupts the growth of the diseased tissue. In addition, this invention provides methods of treating psoriasis, scleroderma, eczema or atopic dermatitis by eliciting an immune response in an individual against an antigen which is only exposed to antibody detection in tissues affected by these disorders | 2009-11-12 |
20090280504 | NS1-NP Diagnostics of Influenza Virus Infection - The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced sensitivity and reliability compared to either antigen alone. Many formats employ pan-specific antibodies (i.e., that react with all or at least with multiple strains within an influenza type). | 2009-11-12 |
20090280505 | METHOD FOR DETECTING LYSOSOMAL STORAGE DISEASES - A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay with lysosomal storage diseases. A body fluid such as urine or blood can be employed as a specimen. The assay can be performed by use of a polypeptide that is capable of specifically binding to a glycosaminoglycan-containing molecule. The polypeptide may be an antibody, or a polypeptide having an antigen-binding site of an antibody. | 2009-11-12 |
20090280506 | SF, A NOVEL FAMILY OF TASTE RECEPTORS - The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors. | 2009-11-12 |
20090280507 | METHOD FOR MEASUREMENT OF SARS VIRUS NUCLEOCAPSID PROTEIN, REAGENT KIT FOR THE MEASUREMENT, TEST DEVICE, MONOCLONAL ANTIBODY DIRECTED AGAINST SARS VIRUS NUCLEOCAPSID PROTEIN, AND HYBRIDOMA CAPABLE OF PRODUCING THE MONOCLONAL ANTIBODY - The present invention provides a method for measuring SARS virus nucleocapsid protein (SARS-NP) using first and second antibodies both binding specifically to SARS-NP, wherein the first or second antibody is an antibody recognizing an epitope located in a region (Region C) of amino acid 283 to 422 from the N-terminus of the amino acid sequence of SARS-NP. | 2009-11-12 |
20090280508 | Methods and Reagents for Preparing and Using Immunological Agents Specific for P-Glycoprotein - This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for identifying and characterizing anticancer compounds. | 2009-11-12 |
20090280509 | SURFACE ACOUSTIC WAVE IMMUNOSENSOR FOR DIAGNOSING ALLERGY DISEASE AND METHOD FOR DIAGNOSING ALLERGY DISEASE USING THE SAME - A surface acoustic wave (SAW) immunosensor for diagnosing allergy disease includes one or more SAW devices on each of which allergens derived from one allergy-causing substance are fixed and an allergen derived from another allergy-causing substance is not included, that is, allergens derived from different allergy-causing substances being fixed on different SAW devices; and a signal detector which detects an output signal from the SAW device. Also a method for diagnosing allergy disease is capable of measuring levels of allergen-specific IgE and total IgE in blood or another sample taken from a subject of diagnosis using a SAW immunosensor, the allergens being derived from various allergy-causing substances, thereby capable of effectively diagnosing allergy disease for various allergy-causing substances. | 2009-11-12 |
20090280510 | Antibodies Specific to Heterodimers of Bcl-2 Family and Uses Thereof - Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient. | 2009-11-12 |
20090280511 | Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to MHC class I molecules - An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of MHC I-mediated antigen presentation in which a T cell antigen epitope is more efficiently presented on MHC I molecules when it is positioned at the N-terminal side than when positioned at the C-terminal side. | 2009-11-12 |
20090280512 | TUMOR MARKER FOR RENAL CANCER AND METHOD FOR DETERMINATION OF OCCURRENCE OF RENAL CANCER - The present invention provides a tumor marker more highly specific to renal cancer. The present invention provides a method for identifying the morbidity of renal cancer. A tumor marker for renal cancer comprising proteins identified from renal cancerous tissue. A method for identifying the morbidity of renal cancer by using the tumor marker for renal cancer. The method comprises measuring the level of the protein in a sample derived from a person of interest who is to be examined to identify the morbidity of renal cancer; and comparing an obtained measured level to a normal level of the protein, wherein an upregulation or a downregulation of the obtained measured level compared to the normal level is used as one of indexes indicating that there is a high possibility that the person of interest has renal cancer. | 2009-11-12 |
20090280513 | COMPOSITIONS AND METHODS FOR DETECTION, PREVENTION, AND TREATMENT OF ANTHRAX AND OTHER INFECTIOUS DISEASES - Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods of immunizing humans or animals against | 2009-11-12 |
20090280514 | METHOD FOR MEASUREMENT OF CHOLESTEROL IN HIGH-DENSITY LIPOPROTEIN - The present invention provides a method, a reagent and a kit for the simple and accurate measurement of HDL cholesterol. The method for the measurement of cholesterol in high-density lipoprotein in a sample comprises reacting the sample with i) cholesterol esterase and cholesterol oxidase or ii) cholesterol esterase, oxidized coenzyme and cholesterol dehydrogenase in an aqueous medium comprising a specific nitrogen-containing surfactant having the structure of amine or ammonium salt and a polyanion, and measuring the formed hydrogen peroxide or reduced coenzyme. | 2009-11-12 |
20090280515 | COMPOSITIONS AND METHODS FOR THE MODULATION OF PGRMC1 - The present invention provides for novel assays and the use of such assays for screening compounds that affect PGRMC1's and related homologue's ability to catalyze the incorporation of cholesterol into membranes. The present invention also provides for methods and compositions for affecting incorporation of cholesterol into membranes. The invention also provides for diagnostic and therapeutic kits for the methods described herein. | 2009-11-12 |
20090280516 | CRYSTAL STRUCTURE OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF - The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a site within the polypeptide. A method is also provided. In general terms, the method comprises computationally identifying a compound that binds to an ALDH polypeptide, using the atomic coordinates. | 2009-11-12 |
20090280517 | METHODS OF DIAGNOSIS AND PROGNOSIS FOR A MUSCULAR DYSTROPHY - The invention relates to the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. The present inventors have found that the quantity of mu-crystallin is increased in a muscular dystrophy. In particular, the inventors have found that mu-crystallin is increased in facioscapulohumeral muscular dystrophy (FSHD). Based on the inventors' findings, the invention provides a novel means for the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. | 2009-11-12 |
20090280518 | SYSTEM FOR HIGH THROUGHPUT MEASUREMENT OF MECHANICAL PROPERTIES OF CELLS - A system for measuring a mechanical property of a cell is provided. The system includes a body having a channel therethrough with a first end and a second end, the channel including at least one cell deforming feature configured to deform a cell passing through the channel. A first sensor system is positioned on the first end side of the cell deforming feature and a second sensor system is positioned on the second end side of the cell deforming feature, and the first and second sensor systems are configured to detect information about a cell as the cell travels across the cell deforming feature. A controller communicating with the first and second sensor systems is adapted to receive data from the first and second sensor systems and calculate a mechanical property of the cell. | 2009-11-12 |
20090280519 | BIOMARKERS FOR ASSESSING LIVER FUNCTION - A method for assessing liver function in an individual, which method comprises determining the level of methylarginine(s) (such as ADMA and/or SDMA) and the ratio of ischemia modified albumin (IMA):albumin ratio (IMAR) in the individual, thereby to assess liver function in the individual. | 2009-11-12 |
20090280520 | FLUORESCENT SEMICONDUCTOR PARTICLES, METHOD OF MANUFACTURING THE SAME, BIOSUBSTANCE FLUORESCENT LABELING AGENT EMPLOYING THE SAME, AND BIOIMAGING METHOD THEREOF - Disclosed is a fluorescent semiconductor particle having a core/shell structure composed of a core particle as a semiconductor particle, and a shell layer by which the core particle is covered, wherein the core particle has a different chemical composition from that of the shell layer; the core particle has an average particle diameter of 1-15 nm and a specific gravity of 1.0-3.0; and the fluorescent semiconductor particle having the core/shell structure has a specific gravity of 0.8-3.2 | 2009-11-12 |
20090280521 | Methods for Drug Discovery, Disease Treatment, and Diagnosis Using Metabolomics - The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed. | 2009-11-12 |
20090280522 | Method For Rapid Detection And Evaluation Of Cultured Cell Growth - Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of a microorganism also contained therein, by oxygen-dependent quenching of phosphorescence; or the gel contains a fluorescent pH indicator that demonstrates growth of the microorganism by pH-dependent intensity change or wavelength shift in the emission spectrum. Further provided is a system and method for killing undesirable microorganisms or colonies in the culture medium without harming the surrounding microorganisms. | 2009-11-12 |
20090280523 | Method for determining the molecular composition of a target tissue or another body structure, and its diagnostic applications - The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10 | 2009-11-12 |
20090280524 | SOLID CULTURE MEDIUM FOR THE DETECTION AND/OR THE SPECIES DISCRIMINATION OF GLYCOPEPTIDE-RESISTANT ENTEROCOCCI - The present invention relates to a solid culture medium for the detection and/or discrimination, among glycopeptide-resistant enterococci, of the groups of species | 2009-11-12 |
20090280525 | PROCESS FOR THE ENANTIOSELECTIVE REDUCTION AND OXIDATION, RESPECTIVELY, OF STEROIDS - A process for the enantioselective enzymatic reduction of compounds which comprise a steroid structure (ABCD) including one or several heteroatoms, one or several double bonds and/or one aromatic component in the ring structure and have at least one oxo group at position 3, 7, 11, 12 or 17 in the steroid ring system or in the α-position at any carbon moiety on the steroid skeleton (=oxosteroid compound), | 2009-11-12 |
20090280526 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of
| 2009-11-12 |
20090280527 | Amylase variants - The present invention relates to variants of a parent α-amylase, which parent α-amylase (i) has an amino acid sequence selected from the amino acid sequences shown in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, and SEQ ID No. 7, respectively; or (ii) displays at least 80% homology with one or more of these amino acid sequences; and/or displays immunological cross-reactivity with an antibody raised against an α-amylase having one of these amino acid sequences; and/or is encoded by a DNA sequence which hybridizes with the same probe as a DNA sequence encoding an α-amylase having one of these amino acid sequences; in which variant: | 2009-11-12 |
20090280528 | Method for Cloning and Expression of NruI Restriction Endonuclease - Recombinant DNA encoding NruI- and SboI-like restriction endonucleases and methylases and their amino acid sequences are provided as well as methods for expressing the enzymes in transformed host cells and purifying the enzymes. | 2009-11-12 |
20090280529 | HIGH THROUGHPUT TRANSFECTION OF FILAMENTOUS FUNGI - The present invention provides a method for the transfection of filamentous fungal cells, comprising providing a multitude of containers, filling into each container an amount of polymer needed for the transfection, filling the cells to be transfected as well as an aqueous solution of transfection reagent into each of the containers, incubating the resulting mixture, removing the transfection reagent from the incubated mixture; and selecting the cells which have been transformed, characterized in that the total volume of the incubating mixture is less than 1 ml per container. Furthermore, the present invention provides the use of transformed filamentous fungal cells for the production of proteins or metabolites. | 2009-11-12 |
20090280530 | NOVEL COLLAGEN-LIKE PROTEIN CLAC, PRECURSOR THEREOF AND GENES ENCODING THE SAME - A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same. | 2009-11-12 |
20090280531 | Preparation of Soluble Capsid Proteins of Picornaviruses Using SUMO Fusion Technology - A method of producing a soluble capsid protein of a picornavirus using a novel and efficient SUMO fusion protein expression system. | 2009-11-12 |
20090280532 | SERUM-FREE MAMMALIAN CELL CULTURE MEDIUM, AND USES THEREOF - The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells. | 2009-11-12 |
20090280533 | SERUM-FREE MAMMALIAN CELL CULTURE MEDIUM, AND USES THEREOF - The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells. | 2009-11-12 |