46th week of 2021 patent applcation highlights part 10 |
Patent application number | Title | Published |
20210353739 | THERMAL INACTIVATION OF ROTAVIRUS - Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus. | 2021-11-18 |
20210353740 | HIV-1 ENV FUSION PEPTIDE NANOPARTICLE CARRIER CONJUGATES AND THEIR USE - Embodiments of immunogenic conjugates including the HIV-1 Env fusion peptide and methods of their use and production are disclosed. In several embodiments, the immunogenic conjugates can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject. | 2021-11-18 |
20210353741 | VACCINE COMPOSITIONS FOR THE TREATMENT OF CORONAVIRUS - The present disclosure provides compositions and methods useful for preventing and/or treating coronavirus infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (VLPs) which comprise one or more Moloney Murine leukemia virus (MMLV) core proteins and include one or more coronavirus epitopes, such as, for example, from SARS-Cov-2 spike protein. | 2021-11-18 |
20210353742 | IMMUNOGENIC COMPOSITION AND USE THEREOF - An immunogenic composition, a SARS-CoV-2 vaccine and a vector are introduced. The immunogenic composition has a recombinant protein having a sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and any polypeptide encoded by a polynucleotide which is at least 80% homologous with SEQ ID NO: 1-4, wherein the recombinant protein contains an IgG1 Fc protein fragment having a length of at least 6 amino acids; or a nucleic acid molecule encoding the recombinant protein. The SARS-CoV-2 vaccine has the above recombinant protein or the nucleic acid molecule encoding the above recombinant protein. The vector has the nucleic acid molecule encoding the above recombinant protein. | 2021-11-18 |
20210353743 | BIOMATERIAL-BASED COVID-19 VACCINE - Disclosed are compositions and methods for preventing an infection, such as COVID-19 infection, comprising administering to the subject an oxygen-generating cryogel, wherein the oxygen-generating cryogel comprises an antigen, a chemoattractant for immune cells, an adjuvant, such as toll-like receptor 9 (TLR9) ligand, and an oxygen-producing compound. Described herein are methods of modulating the immune system in a subject, comprising administering an effective amount of the vaccine described herein to the subject, thereby modulating the immune system in the subject. | 2021-11-18 |
20210353744 | ADMINISTRATION OF HOMOLOGOUS ADENOVIRAL VECTORS - Compositions comprising a recombinant adenovirus of type Ad26 comprising a polynucleotide that encodes an antigen, kits of parts and methods of using these compositions for inducing an immune response in a subject are provided. | 2021-11-18 |
20210353745 | METHODS AND REAGENTS TO TREAT ALLERGY - Compositions, reagents and methods to treat allergy are described. In one aspect, the compositions and reagents involve an oral mucosa delivery system comprising an antigen causing said condition and an immune activity enhancing agent. The methods and regents to treat allergy also relate to applying the combination of allergen and immune activity enhancing agent either as a physical mixture or as synthetic conjugate to a subject in need. | 2021-11-18 |
20210353746 | CYTOSOLIC DELIVERY OF PEPTIDES USING PROTEIN TRANSDUCTION DOMAIN MIMICS - The invention provides compositions and methods for cytosolic delivery of peptides and antigens as well as concomitant delivery of antigens and agonists via poly-norbornene-based protein transduction domain mimics. | 2021-11-18 |
20210353747 | USE OF PLANT EXOSOMES FOR SHOWING MODULATING EFFECTS ON IMMUNE SYSTEM CELLS - Use of the effects of plant exosomes on the immune system as immune system enhancers, silencers and modulators against diseases is disclosed. The plant derived exosomes are obtained from at least one portion of the plant selected from the group consisting of the entire plant, fruit, leaf, seed, root, or differentiated tissues like the plant's tissue culture medium, stem cell, waste material, shell or phloem. In the scope of the invention, the plant exosomes having immunomodulatory effects are used mainly in autoimmune diseases, and in cell, tissue, organ transplantations and in Graft Versus Host disease as immune system enhancers, suppressors or, if necessary, as modulators performing both of the first two functions. | 2021-11-18 |
20210353748 | TARGETING moDC TO ENHANCE VACCINE EFFICACY ON MUCOSAL SURFACE - Described herein are novel vaccine compositions and methods for use thereof in inducing an immune response in a subject especially aged subjects. Specifically exemplified are vaccine compositions that include an antigen; a cyclic dinucleotide; soluble tumor necrosis factor (TNF); or a CD64 antibody or antibody fragment. Optionally, the vaccine composition comprises a TNF conjugated with a moDC targeting moiety in addition to or in place of TNF or CD64 antibody or antibody fragment, or both TNF and CD64 antibody or antibody fragment. | 2021-11-18 |
20210353749 | GUANABENZ AS AN ADJUVANT FOR IMMUNOTHERAPY - Guanabenz for use with an immunotherapy in the treatment of a cancer or of an infectious disease. In particular, guanabenz is used as an adjuvant for an immunotherapy, such as a cancer immunotherapy or a vaccination. More specifically, guanabenz for use with an adoptive cell therapy, with a therapeutic vaccine, with a checkpoint inhibitor therapy or with a T-cell agonist therapy in the treatment of a cancer. Also, guanabenz for use with a vaccination in the prophylactic and/or therapeutic treatment of an infectious disease. | 2021-11-18 |
20210353750 | Methods of Treating Cancer - The present disclosure provides methods of treating cancer and methods for selecting treatment approaches for cancer. | 2021-11-18 |
20210353751 | COMBINATION THERAPIES FOR TREATMENT OF INFLAMMATORY DISEASES - The present application relates to a combination therapy for treatment of inflammatory diseases comprising an immunomodulator compound and a GABA-receptor agonist in an amount effective to reduce inflammation and ameliorate disease. In certain embodiments, the present application relates to treatment of T1D by administering an immunomodulator compound and a GABA-receptor agonist in an amount effective to prevent, reduce, and/or treat hyperglycemia in the human or animal subject. In certain embodiments, the immunomodulator compound and GABA-receptor agonist are administered in an amount effective to control autoimmune responses and safely increase β-cell mass and function in the context of established β-cell autoimmunity. | 2021-11-18 |
20210353752 | TREATMENT WITH HIGHLY SILYLATED IGG COMPOSITIONS - Compositions comprising a highly sialylated IgG preparation and methods for treating a patient using such preparations are described. This application is based, in part, on the surprising discovery that a dose of a highly sialylated IgG (hsIgG) preparation that is about 1%-10% of the effective dose for IVIG can be effective for treating disorders that are treated with IVIG. | 2021-11-18 |
20210353753 | Subcutaneous anti-HER2 Antibody Formulations and Uses Thereof - The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided. | 2021-11-18 |
20210353754 | PIGMENT FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY - A nonstaining photosensitizer includes powdered Nigella sativa seeds in a carrier medium. A method of antimicrobial photodynamic therapy includes administering a photosensitizing composition comprising a Nigella sativa pigment to a treatment site and irradiating the treatment site with a wavelength effective to photoactivate the photosensitizing composition to ablate microorganisms and/or diseased tissue. | 2021-11-18 |
20210353755 | REDUCTION OF POST-SURGERY CANCER METASTASIS BY COMBINATION OF CANNABIDIOL AND NR2F6 INHIBITION - Disclosed are means of stimulating systemic immunity and reduction of post-surgery tumor metastasis through the concurrent intralymphatic inhibition of NR2F6 and treatment with cannabidiol. In some embodiments NR2F6 is inhibited by high pressure transient delivery of short interfering RNA into tumor draining lymph nodes concurrent with systemic administration of cannabidiol. This combination may be performed together with means that induce immunogenic tumor cell death. Through the combination of immunogenic cell death and immune stimulation, the invention provides a means of enhancing the abscopal effect and in some embodiments to cause immunological mediated destruction primary and secondary neoplasia. | 2021-11-18 |
20210353756 | COMPOSITIONS AND METHODS FOR STABILIZING PROTEIN-CONTAINING FORMULATIONS - The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in therapeutically useful formulations thereof. | 2021-11-18 |
20210353757 | NANOBODY PREPARATION SYSTEM FOR ADMINISTRATION THROUGH INTERNAL AND EXTERNAL EPIDERMIS OF HEAD AND NECK AND PREPARATION METHOD AND USE - Disclosed is a nanobody preparation system for administration through the internal and external epidermis of head and neck and internal epidermal layer of nasal cavity, comprising a specific nanobody having a biological activity and an antibody-drug carrier for improving the stability and tissue penetration of the nanobody. The drug carrier comprises one or more of a water-soluble macromolecular bio-saccharide gum substrate, polyvinyl alcohol, polyamino acid, glycerine, phospholipid, sodium carboxymethyl cellulose, collagen, and a hydrolase inhibitor. | 2021-11-18 |
20210353758 | MICROCARRIER FOR EMBOLIZATION AND PREPARATION METHOD THEREFOR - The present disclosure relates to a microcarrier for embolization, and a preparation method therefor, wherein the microcarrier comprises a biodegradable porous polymer, a stimulus-responsive polymer captured in the biodegradable porous polymer, and drug-supported magnetic nanoparticles captured in the stimulus-responsive polymer, thereby being capable of operating in an in vivo tumor-targeting manner and releasing, by an external stimulus, the drug-supported nanoparticles, so as to be effectively usable in tumor embolization. | 2021-11-18 |
20210353759 | EYEDROP COMPOSITIONS - An eyedrop composition, and methods of making and using the same, may include one or more hydrogel forming polymer having an intrinsic viscosity [η] of at least 3 dL/g in the composition, wherein a concentration C | 2021-11-18 |
20210353760 | PRO-CYCLIC DINUCLEOTIDES AND PRO-CYCLIC DINUCLEOTIDE CONJUGATES FOR CYTOKINE INDUCTION - The present invention provides a Pro-cyclic dinucleotide (Pro-CDN) comprising a STING agonist cyclic dinucleotide which is coupled to a linker system. The Pro-CDNs of the present invention can be metabolized at a targeted site into CDNs and exert their full immunomodulatory effects at said targeted site. The present invention also provides conjugates wherein a Pro-CDN is conjugated to a Biologically Active Molecule (BAM) such as e.g. a cytotoxic molecule, a lipid, a protein, a peptide, a nucleic acid, a sugar or a PRR ligand. The invention provides also methods related to the use of such compounds to perform their activities at their targeted sites, to exert cytotoxic, cytostatic or immunomodulatory effects, to treat or to prevent diseases such as cancers, immunological disorders or infections. | 2021-11-18 |
20210353761 | ICE-BASED LIPID NANOPARTICLE FORMULATION FOR DELIVERY OF MRNA - The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids. | 2021-11-18 |
20210353762 | DENDRIMER COMPOSITIONS AND METHODS FOR TREATMENT OF SEVERE ACUTE RESPIRATORY DISTRESS SYNDROME - A method for treating or preventing one or more symptoms of severe inflammation in the lung of a subject in need thereof includes administering to the subject a composition comprising dendrimers complexed, covalently conjugated, or intra-molecularly dispersed or encapsulated with one or more therapeutic or prophylactic agents, in an amount effective to treat, alleviate or prevent one or more symptoms of severe inflammation. The compositions and methods are useful for treating disorders characterized by cytokine storm, for example, for treating or preventing acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) results in from ventilator use or infection such as with COVID-19, sepsis, and systemic bacterial infections in a subject in need thereof have been established. Preferably, the dendrimers are generation 4, 5, 6, 7, or 8 poly(amidoamine) (PAMAM) dendrimers, and the therapeutic agents are one or more anti-inflammatory and/or anti-oxidant agents such as N-acetyl cysteine. | 2021-11-18 |
20210353763 | SITE-SPECIFIC COVALENT CHEMICAL LIGATION TO MONOCLONAL AND POLYCLONAL IMMUNOGLOBULIN - Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload. | 2021-11-18 |
20210353764 | LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF - The present invention relates to a ligand-drug conjugate of an exatecan analogue, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description. | 2021-11-18 |
20210353765 | COMPOUNDS AND THERAPEUTIC USES THEREOF - The invention relates to novel compounds with the ability to link an immune response to a defined therapeutic target, to the use of said compounds in treating cancer and infectious diseases, to compositions containing said compounds, processes for their preparation and to novel intermediates used in said process. | 2021-11-18 |
20210353766 | SULFAMIDE LINKERS FOR USE IN BIOCONJUGATES - The invention relates to a novel linker for use in bioconjugates such as antibody-drug-conjugates. The linker according to the invention is represented by formula: | 2021-11-18 |
20210353767 | COMPOSITIONS AND METHODS FOR DRUG DELIVERY - Disclosed herein are methods for drug delivery, as well as kits for drug delivery. | 2021-11-18 |
20210353768 | TARGETING MOIETY-DRUG GRAFTED IMMUNE CELL COMPOSITIONS AND METHODS OF USE - Surface-engineered immune cells, such as natural killer cells, grafted with targeting moiety-drug complexes. The present invention combines chemotherapy and immunotherapy by engineering the immune cells to target specific tumor cells through antigen recognition and deliver potent chemotherapeutic agents, thereby destroying the tumor cells. The surface-engineered immune cells may be prepared using a one-step method. The present invention also provides kits for preparing the surface-engineered immune cells. | 2021-11-18 |
20210353769 | SURFACE MODIFIED EXTRACELLULAR VESICLES - The invention relates to surface modified extracellular vesicles, wherein the extracellular vesicles comprise an exogenous polypeptide tag that is covalently linked to a membrane protein of the extracellular vesicles. In a particular embodiment, the tag is covalently linked to the membrane protein of microvesicles by sortase-mediated ligation. Methods of preparing said extracellular vesicles and methods of using said extracellular vesicles loaded with therapeutic molecules for treating a disease are also disclosed herein. | 2021-11-18 |
20210353770 | Delivery of Urea to Cells of the Macula and Retina Using Liposome Constructs - Provided are liposome constructs for delivery of urea to the vitreoretinal interface of the eye. The liposome constructs are agglomerates of small lamellar vesicles (SUVs) and have a greater density than the vitreal fluid, such that they sink to the back of the eye rather than dispersing throughout the vitreous. | 2021-11-18 |
20210353771 | Compositions and Methods for Treating Dopamine Disorders - Compositions comprising clathrin nanoparticles and methods for treating dopamine-associated addictions, disorders, and neurodegenerative diseases using the same. | 2021-11-18 |
20210353772 | METHOD OF MAKING A BIOCOMPATIBLE MICRO-SWIMMER AND METHOD OF USING SUCH A MICRO-SWIMMER - The present invention relates to a method of making a biocompatible micro-swimmer, the method comprising the steps of: providing a photo cross-linkable biopolymer solution; adding magnetic particles and a photo initiator to the photo cross-linkable biopolymer solution to form a 3D-printable solution; applying a laser with a variable focus directed at the 3D-printable solution; varying the focus of the laser through the 3D-printable solution to form the biocompatible micro-swimmer with a predefined shape; and applying a chemical linker to the biocompatible micro-swimmer having the pre-defined shape. The invention further relates to such a micro-swimmer and to a method of using such a micro-swimmer. | 2021-11-18 |
20210353773 | SYNP194 (PROB15), A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN RETINAL GANGLION CELLS - The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 1400 bp having at least 80% identity to said sequence of SEQ ID NO:1, and related uses, wherein said isolated nucleic acid molecule specifically leads to the expression in retinal ganglion cells of a gene when operatively linked to a nucleic acid sequence coding for said gene. | 2021-11-18 |
20210353774 | COMPOSITIONS AND METHODS FOR TREATING LEBER?S HEREDITARY OPTIC NEUROPATHY WITH NADH DEHYDROGENASE PROTEINS - Disclosed herein is a recombinant nucleic acid, comprising: a mitochondrial targeting sequence; a mitochondrial protein coding sequence, wherein said mitochondrial protein coding sequence encodes a polypeptide comprising a mitochondrial protein; and a 3′UTR nucleic acid sequence. Also disclosed is a pharmaceutical composition comprising the recombinant nucleic acid and a method of treating Leber's hereditary optic neuropathy (LHON) using the pharmaceutical composition. | 2021-11-18 |
20210353775 | METHOD AND COMPOSITION FOR TREATING NEUROPATHIC PAIN - The present invention provides a therapy for treating neuropathic pain by subpial administration of small quantities of a composition for spinal segment-specific upregulation of GAD65 (glutamatedecarboxylase) gene and VGAT (vesicular GABA transporter) gene, which is effective for induction of nociceptive effects by potentiating release of vesicular GABA from infected dorsal horn neurons into the synaptic cleft. | 2021-11-18 |
20210353776 | IMMUNOADSORPTION - Upon administration of rAAV vectors the humoral immune response (neutralizing antibodies) is the first barrier that needs to be overcome. Surprisingly it was found that by using immunoadsorption for depletion of immunoglobulins from the blood (plasma), subjects can be highly efficiently treated with rAAV vectors, i.e. obtain highly efficient transduction after rAAV vector administration, in spite of the presence of high levels of nAb. | 2021-11-18 |
20210353777 | SPECIFIC CONJUGATION LINKERS, SPECIFIC IMMUNOCONJUGATES THEREOF, METHODS OF MAKING AND USES SUCH CONJUGATES THEREOF - The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders. | 2021-11-18 |
20210353778 | MEDICAL IMAGING TECHNIQUE USING X-RAY TO NEAR-INFRARED DOWNCONVERTING NANOPOWDER - A phosphor excitable by X-ray and blue-light emits light in the near-infrared (NIR-II, 1000-1700 nanometers) forms nanoparticles less than 200 nanometers diameter. The nanoparticles are tagged by coating with silica, then conjugating with polyethylene glycol (PEG) and tissue-selective compounds such as antibodies, nucleic acid chains, and other ligands. In embodiments, we administer the tagged nanoparticles to a subject, then localize the nanoparticles, and thus antigen-bearing tissues, by irradiating the subject with X-ray or other radiation beams while imaging near infrared light emitted from the subject. The nanoparticles are made by mixing 1-50 micron calcium oxide and germanium oxide powders with dilute nitric acid, adding chromium (III) nitrate at a ratio to germanium between 0.001 and 0.1, adding tartaric acid solution with molar ratio to metal ions between 1-10, and adjusting pH to 0.1-4 with nitric acid, then later heating to form a sol, oven drying, and calcinating the sol. | 2021-11-18 |
20210353779 | GOLD NANOPARTICLE-LIGAND CONJUGATES AND METHODS OF USE - Gold nanoparticles are conjugated to phosphatidylserine-specific ligands for targeting and binding to surface-exposed phosphatidylserine on tumor cells and tumor vasculature. The ligand may be an annexin (e.g., annexin V). Tumor contrast is significantly increased using the targeted gold nanoparticles. Breast cancer tumors as small as 4 mm, for example, were detectable via computed tomography (CT) within 4 hours after injection of the conjugates, demonstrating usefulness of the conjugates as imaging agents. The targeted gold nanoparticle conjugate may further have a drug conjugated thereto that can be used therapeutically, for example, for cancer treatment. The gold nanoparticle conjugates can also be used for photothermal therapy and can be used in concert with an X-ray radiation treatment for cancer treatment. | 2021-11-18 |
20210353780 | ASCORBATE FORMULATIONS AND METHODS OF USE AS CONTRAST AGENTS - A sterile aqueous composition suitable for use as an MRI contrast agent includes 100 to 600 mM ascorbate; and 100-600 mM sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mOsm/L. | 2021-11-18 |
20210353781 | SURFACE-MODIFIED CELLS, METHODS OF MAKING AND USING - Surface-modified cell containing a cell and a conformal coating on the extracellular surface of the cell are described. The conformal coating contains two or more layers containing particles (e.g. nanoparticles) or macromolecules. The cell is an islet cell, a B cell, or a T cell. The macromolecules or particles are formed from zwitterionic polymers. Covalent linkages are employed to link the particles or macromolecules to a cell surface molecule containing an abiotic functional group, or between macromolecules and/or particles in adjacent layers. Also described are methods of making and using a surface-modified cell. | 2021-11-18 |
20210353782 | PHOTOACOUSTIC ION INDICATORS - A system for measuring the membrane potential of a neuron is disclosed. The system comprises one or more photoacoustic ion indicators, each comprising a metal chelating agent linked to a chromophore molecule. The metal chelating agent is configured to selectively bind to one of sodium ions, calcium ions, and potassium ions. The system further comprises a photoacoustic probe including a laser configured to emit a light signal to the chromophore and an ultrasound transducer configured to receive a photoacoustic signal in response to the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer, determine a quantity of photoacoustic ion indicators exhibiting the shift, and calculate a membrane potential of the neuron based on quantity of photoacoustic ion indicators exhibiting the shift. | 2021-11-18 |
20210353783 | IMAGING AGENTS FOR RADIOLABELING EXOGENOUS AND ENDOGENOUS ALBUMIN - The present disclosure provides albumin-binding radioactive metal complexes and uses thereof, including diagnosing and treating disease. | 2021-11-18 |
20210353784 | DETECTING AND TREATING CANCERS USING CELL PENETRANT MTP53-OLIGOMERIZATION-DOMAIN PEPTIDE - Peptide formulations of a general formula of X-mtp53ODP, where mtp53ODP is a peptide that binds to tetrameric mp53 tetramers in vivo. X is a detection agent, such a fluorophore or radioligand, and/or a DNA-damaging agent. The primary structures of suitable mtp53ODPs are given as SEQ ID NOS: 1-8. | 2021-11-18 |
20210353785 | Systems and Methods for Detection, Treatment, Prevention, and Protection - Systems and methods for detection, treatment, prevention and protection are shown and described. UVC may be used in such applications. | 2021-11-18 |
20210353786 | HANDHELD UV-C SANITIZING APPARATUS AND METHOD - A handheld UV-C sanitizing apparatus is provided and includes: (a) an enclosure defining an opening for light exposure and fabricated from quartz that is transparent or plastic; (b) a plurality of light emitting diodes (LEDs) configured to emit UV-C light; (c) a circuit board, wherein each LED is coupled to the circuit board and each LED is removable and replaceable independently; and (d) a power source coupled to the circuit board, wherein the power source configured to deliver power to each LED. The UV-C light emitted from the LEDs is at a wavelength suitable to kill, destroy, or reduce growth of microorganisms and germs in a preset exposure area directly below the UV-C light. The arrangement of the LEDs spaced apart from each other is configured to emit cones of UV-C light emission sufficient to cover the preset exposure area corresponding to a user's hand surface area. | 2021-11-18 |
20210353787 | Using a Steerable Beam of RF Energy to Eliminate Viruses and/or Bacteria From a Volume of Air - Pathogens (e.g., viruses or bacteria) within a volume of air can be killed or deactivated using RF energy. A plurality of phase shifters input an RF signal and output a phase-shifted version of the RF signal at their respective outputs, wherein an amount of phase shift introduced by each of the phase shifters is controllable. A phased array antenna has a plurality of microwave radiators, and each of the respective outputs of the phase shifters drives a respective one of the microwave radiators. A controller controls the phase shifters to drive the phased array antenna such that a beam of RF energy emanates from the phased array antenna and sweeps through a volume positioned in front of the phased array antenna, and the beam of RF energy kills or deactivates the pathogens. | 2021-11-18 |
20210353788 | WEARABLE DECONTAMINATION SYSTEM - A same-hand, finger-mounted, and finger-operated hand sanitizer dispensing system with finger-mounted or with remote-mounted fluid reservoir, is disclosed herein. The system is operable without risk of cross-contamination, and is operable by the contaminated hand for self-decontamination. A dispensing pump is mounted on one finger and operated by another finger on the same hand. The dispensing pump draws sanitizer from a reservoir by way of a supply tubing. The reservoir can be mounted on the same finger as the pump or on another finger of the same hand. | 2021-11-18 |
20210353789 | SELF-DISINFECTING OBJECT - The invention relates to a self-disinfecting object having a contact surface of a substrate provided for contact with a human body part, wherein the contact surface is at least regionally heatable. | 2021-11-18 |
20210353790 | PATHOGEN-INACTIVATING FACIAL MASK - A facial mask having pathogen inactivation capabilities is disclosed. One embodiment comprises a mask and a pathogen inactivation system coupled to the mask. The pathogen inactivation system is configured to heat and inactivate bacteria and viruses. | 2021-11-18 |
20210353791 | SYSTEM FOR NEUTRALIZING BIOLOGICAL ORGANISMS - A system and method for neutralizing a biological organism is provided. The system includes a first pyrotechnic element. A first element is made from decontamination material, the decontamination material decomposing into a decontamination gas in response to thermal energy from the first pyrotechnic element. a selectively sealable chamber is fluidly coupled to the first element to receive the decontamination gas, the chamber being sized to receive an article. | 2021-11-18 |
20210353792 | METHOD AND APPARATUS FOR DECONTAMINATING ARTICLES IN A STEAM STERILIZER AT LOW TEMPERATURE - A method and apparatus for reprocessing decontaminating articles in a steam sterilizer at low temperatures and sub-atmospheric pressure. The method includes steps for operating the steam sterilizer such that it can safely and effectively decontaminate articles at temperatures below conventional steam sterilization processing temperatures. The steam sterilizer includes a low temperature operating mode that processes articles in a chamber at low temperatures and at sub-atmospheric pressure. | 2021-11-18 |
20210353793 | STERILIZATION APPARATUS FOR PORTABLE ELECTRONIC DEVICE - A sterilization apparatus for a portable electronic device including a cabinet and a carrier is provided. The carrier includes a base slidably disposed on the cabinet, multiple first positioning elements and multiple second positioning elements disposed in parallel on the base, multiple sterilization light sources corresponding to the second positioning elements and multiple pressure sensors disposed in parallel in the base. The base is configured to carry at least one portable electronic device. One second positioning element is disposed between any two adjacent first positioning elements, and any first positioning element and any second positioning element adjacent to each other are separated by a positioning space. The pressure sensors are respectively located in the positioning spaces. One sterilization light source is disposed between any two adjacent pressure sensors, and the pressure sensors are configured to sense a pressure from the portable electronic device. | 2021-11-18 |
20210353794 | Method and device to allow antiseptic proximity seating - With respect to pandemics, restaurants, stadiums, cafeterias, and bars are among the most dangerous places to socialize due to the form of interaction. Exchange of bacteria and viruses are facilitated intensively from the mouth and nose via air transport in droplets of saliva and bodily fluids being deposited on surfaces, foods, and in the air. The present development creates a comfortable environment where the air-space of each customer is separated by invisible cold-hot air and vis-UV barriers, which take away bacteria and viruses, destroying them and preventing recirculation while offering pleasant, clean, and sanitized ambient conditions for a face to face meeting. An immersive experience can be provided with surrounding screens and gas therapy that may be customized according to the customer's preferences. Food distribution is performed with a robotic shuttle system and when the customer departs, an extensive cleanup is performed using chemicals and UV irradiation through robotic systems. | 2021-11-18 |
20210353795 | CONTAINER WITH AUTOMATIC STERILIZATION FUNCTION - The present invention provides a container with automatic sterilization function, the container is combined with a first cover body and a second cover body which are connected to each other. The first cover body and the second cover body can be lifted up by using a hinge structure, and combined by using a set of catching groove and snap. The second cover body and container are combined tightly or separated by screwing opposite screw thread sections. The inner face of inner chamber of the first cover body has a reflective layer made of reflecting material. A circuit structure is disposed in the main body of the second cover body (and in the inner chamber of the first cover body). A suction port is disposed on the surface of the second cover body towards the first cover body, more than one first UV light source structure is disposed around to irradiate the suction port. Another surface towards the container is provided with a second UV light source structure irradiating the inside of container. All of the first UV light source structures and the second UV light source structures are linked with the circuit structure to provide timed sterilization function. In addition, the second cover body is provided with a first sensor for detecting the open/close of the first cover body as the basis of on/off of the first UV light source structure; and a second sensor for detecting the separation/combination of the second cover body and container as the basis of on/off of the second UV light source structure. | 2021-11-18 |
20210353796 | AUTOMATIC UVC SANITIZER FOR COMMON TOUCH POINTS - A low-cost, low-power, motion-activated LED UVC light with intrinsic safety features to automatically sanitize a common touch point after it has been contacted by a human finger or hand. | 2021-11-18 |
20210353797 | Ultraviolet light tower - A disinfecting tower rack, preferably a UV light tower having a base, an upper plate, and a main body separating the base and the upper plate, thus defining an overall height. The UV light tower main body is configured to receive and hold or secure to one or more UV light panels. Each UV light panel may be operationally separate and distinct from adjacent or other UV light panels and are designed to work independently, allowing each panel to be removed without impacting the functioning of any of the other secured or intact UV light panels. | 2021-11-18 |
20210353798 | UNIVERSAL MASK CARRIER AND DECONTAMINATION DEVICE - A mask carrying system comprising a housing that can have a front portion detachably coupled to a back portion, and an outer surface and an inner surface defining an exterior and an interior of the housing. A mask carrying system can further comprise a disinfectant to disinfect an item on the interior of the housing to a 2-log reduction of at least one pathogen. The disinfectant can be a plurality of ultraviolet lights illuminating the interior of the housing. The front portion can substantially conform to a mask shape. The connector plate can be coupled to a power source wherein the power source supplies power to the disinfectant. | 2021-11-18 |
20210353799 | ULTRAVIOLET (UV) DISINFECTOR - An ultraviolet (UV) disinfector is disclosed. The UV disinfector is configured to automatically deliver an effective dose of ultraviolet radiation for antibacterial and antiviral treatment of various surfaces. The UV disinfector could be operated in different operating modes based on the surface disinfection. The UV disinfector comprises a controller having a processor and a memory in communication with the processor, wherein the memory is configured to store a set of instructions, which are executed by the processor. The UV disinfector further comprises an UV light-emitting diode (LED) array, which is securely affixed to a base section of the housing. The UV LED array in communication with the controller is configured to provide a disinfecting illumination with an ultraviolet light to the exterior surface. A plurality of sensors in communication of the controller is configured to send signals to the controller, thereby controlling the operation of the UV disinfector. | 2021-11-18 |
20210353800 | PEROXYCARBOXYLIC ACID BASED SANITIZING RINSE ADDITIVES FOR USE IN WARE WASHING - A concentrated liquid sanitizing and rinse composition containing peroxycarboxylic acid(s) and compatible rinse aid surfactants is disclosed. The sanitizing and rinsing compositions are formulated in a single liquid concentrate, replacing a traditional dual product of a sanitizer and rinse aid. The sanitizing and rinsing chemistries are particularly effective at neutral pHs against gram negative organisms at elevated temperatures. Methods of using the concentrated liquid sanitizing and rinse composition are also disclosed. | 2021-11-18 |
20210353801 | Autonomous Decontamination Device for the Dispersion of Disinfecting, Sanitizing and Barrier Agents for Enclosed Structures - An autonomous device for the vaporization and dispersal of a sanitizing agent adapted for the use in closed structures such as rooms, vehicles, trash bins, dumpsters, and other containers. | 2021-11-18 |
20210353802 | PROCESS AND SYSTEM FOR ULTRASONIC DRY MIST DISPENSER AND OZONE SANITIZER - The system of the present invention is for treating surfaces and airborne particles comprising. The system includes an exterior housing and an enclosed water storage tank mounted inside the exterior housing to store water. The system may also include a dry mist generator mounted on a water float to position the dry mist generator below a surface of the water stored in the enclosed water storage tank. The system may further include an air blower having an outlet connected to water storage tank above a predetermined water level. The system may still further include an oxygen tank having an outlet, and an ozone generator connected to the outlet of the oxygen tank, The system may also include a regulator and flow meter connected to the outlet of the oxygen tank and having an inlet conduit to the ozone generator to regulate a flow of oxygen into the ozone generator. | 2021-11-18 |
20210353803 | CRYOGENIC DISINFECTION SYSTEM AND METHOD - A method of disinfecting an object using cryogenic temperatures, and a cryogenic disinfection device and cryogenic disinfection tunnel for use in such a method are disclosed herein. In various embodiments, one or more chambers are provided, capable of providing an ultralow temperature therein. An object is placed or moved to within the chamber and subjected to ultralow, e.g., cryogenic, temperatures therein for a period of time sufficient to disinfect the object to a desired depth. | 2021-11-18 |
20210353804 | LARGE AREA AUTONOMOUS DISINFECTANT/DECONTAMINATION VEHICLE - An autonomous vehicle for applying a disinfecting/decontamination solution to surfaces within buildings, in outdoor spaces or other structures. The autonomous vehicle uses a dispensing system having an electrostatic charging mechanism which causes atomized dispensing fluid to be attracted to surfaces desired to be disinfected or decontaminated. | 2021-11-18 |
20210353805 | PORTABLE DISINFECTION UNITS FOR OFFICE WORKSTATIONS - A portable disinfection device includes at least one disinfection energy source and a control circuit configured to activate and deactivate the disinfection energy source. A communications means is provided to allow the control circuit to activate and deactivate the disinfection energy source in response to a remote controller. The control circuit is further configured with a countdown timer to automatically deactivate the disinfection energy source after a preset period of operation. A further portable disinfection device includes a light source, and operator interface for controlling the light source, and an operator interface for activating and deactivating the disinfection energy source. | 2021-11-18 |
20210353806 | ELEVATOR STERILIZATION SYSTEM AND ASSOCIATED METHODS - A sterilization device for deactivating pathogens within an elevator cabin is disclosed. The sterilization device comprises a housing, one or more ultraviolet (UV) light sources, a sensor, a processor, and a non-transitory, computer readable medium. The housing defines an interior space containing the UV light sources and an aperture allowing the UV light sources to emit UV light to a coverage zone in the elevator cabin. The sensor is configured to detect a living presence within the coverage zone. Based on instructions stored by the computer readable medium, the processor cycles the UV light sources on a first schedule while the sensor indicates that the living presence is in the coverage zone and cycles the UV light sources on a second schedule for a set period of time once the sensor indicates that the living presence is no longer in the coverage zone. Thereafter, the UV light sources are deactivated. | 2021-11-18 |
20210353807 | ULTRAVIOLET RAY IRRADIATION DEVICE AND ULTRAVIOLET RAY BLOCKING UNIT - To provide an ultraviolet ray irradiation device which, when an operator inserts a glove to the device, prevents irradiation of ultraviolet rays to the outside thus further enhancing safety. An ultraviolet ray irradiation device includes: a sterilization chamber housing having an insertion opening through which a hand on which a glove is mounted is inserted into a sterilization chamber; an ultraviolet ray irradiating unit which irradiates ultraviolet rays to the chamber; ultraviolet ray blocking elastic bodies disposed so as to traverse an insertion direction of the hand, and allowing the hand to penetrate the elastic bodies; and a frame body supporting peripheral edge portions of the stacked elastic bodies. A plurality of cuts are radially formed in the elastic bodies. A plurality of elastic members are formed between the cuts. The respective elastic bodies are mounted on the frame body such that the cuts are displaced from each other. | 2021-11-18 |
20210353808 | FIELD DISINFECTION MOBILE ROBOT AND CONTROL METHOD THEREOF - A field disinfection mobile robot is provided. The field disinfection mobile robot includes a light-emitting device and a mobile device. The light-emitting device includes at least one lamp. The at least one lamp is configured to emit ultraviolet light. The mobile device carries the light-emitting device and includes at least one wheel and a processing circuit. The processing circuit calculates irradiation time according to a level of a lethal dose and intensity of the ultraviolet light and controls a rotation speed of the at least one wheel according to the irradiation time. | 2021-11-18 |
20210353809 | IDENTIFICATION METHOD, CONSTANT TEMPERATURE ASEPTIC STORAGE METHOD AND STERILIZATION CONTAINER - The invention discloses an identification method, a constant temperature aseptic storage method and a sterilization container, and relates to the technical field of sterilization. The identification method maintains the sterilized article at a preset constant temperature after the sterilization is finished, and utilizes the temperature of the sterilized article for identifying whether the sterilized article is sterilized. The constant temperature aseptic storage method is to control the illumination device and the heating air duct of the sterilization container to run in a low-power operation, and continuously release a small amount of ultraviolet light and a small amount of hot air to the article storage cavity of the sterilization container so as to maintain the sterilized article at a preset constant temperature and aseptic condition. The sterilization container is capable of performing the identification method and the constant temperature sterilization method. | 2021-11-18 |
20210353810 | STERILIZATION TEST DEVICE - A sterilization process test device for verifying the efficacy of a sterilization process includes a tubular body defining a chamber for containing at least one sterilization indicator and a cap to sealingly close the tubular body. The tubular body includes at least one hole, which is covered by a gas and steam permeable cover. The only flow path into the chamber is provided through the steam and gas permeable cover and the at least one hole, which when combined are configured to control and restrict a flow of steam or a gaseous sterilization medium from an external environment. | 2021-11-18 |
20210353811 | MANAGEMENT APPARATUS, MANAGEMENT SYSTEM, MANAGEMENT METHOD, AND PROGRAM FOR MANAGING RECORDS OF PROCESSES USING TEST PAPER HAVING DISCOLORATION AREA - A management apparatus that manages a record of a predetermined process carried out using test paper, which has identification information and a discoloration area, is provided. The apparatus includes: obtaining means for obtaining the identification information and a measurement result for the discoloration area, from a measurement apparatus; and recording means for determining a field to be recorded in a target record based on already-recorded fields in the target record which corresponds to the identification information, and recording information in the determined field. The record includes a first field in which the achievement degree of the predetermined process is recorded, and one or more second fields in which information is recorded earlier than a timing at which the achievement degree of the predetermined process is recorded in the first field. | 2021-11-18 |
20210353812 | DISINFECTION PROCESS SAMPLING DEVICE - Various examples disclosed relate to a device for use in a disinfection process. The device can include, for example, a sampling assembly capable of a first position and a second position, wherein the sampling assembly is configured to be used inside a sterilization system. The sampling assembly can include a top portion, a bottom portion, at least one seal therebetween such that the top portion and the bottom portion form an airtight compartment when in the first position, a central pin running through the top portion and bottom portion, and an actuator configured to move the sampling assembly between the first position and the second position along the central pin during a portion of the disinfection process, such that the sampling assembly can collect a sample of atmosphere within the disinfection system. | 2021-11-18 |
20210353813 | GERMICIDAL LIGHTING - Apparatus, methods and instructions for disinfecting air. The apparatus may include, and the methods may involve, a fixture. The fixture may include a germicidal light source. The fixture may include a fan. The fan may circulate air through a volume into which the germicidal light source propagates germicidal light. The light source may be configured to emit, upward from a horizontal plane, a beam that, absent reflection off an environmental object, does not cross the horizontal plane. The apparatus may include a shield that prevents light from the light source from crossing the horizontal plane. The sensor may face upward from the horizontal plane. The sensor may face downward from the horizontal plane. | 2021-11-18 |
20210353814 | MALODOR COUNTERACTANT COMPOSITION AND METHODS - The present invention relates to compositions and methods for malodor reduction. The malodor control compositions are suitable for use in a variety of applications, including use in consumer products, for example, air freshening compositions, laundry detergents, fabric enhancers, surface cleaners, beauty care products, dish care products, diapers, feminine protection articles, animal and pet litter compositions and plastic films for garbage bags. Such malodor control technologies do not unduly interfere with the scent of the perfumed or unperfumed situs that is treated with the malodor control technology. | 2021-11-18 |
20210353815 | SCENTED COLOR-CHANGING SYSTEM - A scented color-changing system for revealing a hidden message, brand, picture, and the like on a substrate such as a paper when a fragrance is applied or released on the substrate. The hidden message contains a color former such as a leuco dye and the fragrance contains a color developer such as zinc chloride that reacts with the color former to reveal the message. The fragrance can be sprayed on the substrate or released from microcapsules embedded in or disposed on the substrate by rupturing the microcapsules. The scented color-changing system is particularly suited for use with fragrance test strips, advertising mailers, magazine inserts, and the like. | 2021-11-18 |
20210353816 | AROMA DIFFUSING DEVICE AND METHOD OF CONTROLLING AROMA DIFFUSING DEVICE - To provide an aroma diffusing device and a method of controlling an aroma diffusing device that can enable a plurality of functions to be achieved by operation inputs to one operation input part. | 2021-11-18 |
20210353817 | AIR STERILIZATION DEVICE AND FILTER - An air sterilization device, comprising: a main housing. A cavity for air circulation is provided in the main housing. The cavity is provided with an air inlet and an air outlet. The air inlet and the air outlet each is provided with a joint. A pulse flashing unit is provided in the cavity, which includes a charging circuit connected to an external power supply. A current output by the charging circuit sequentially passes through a capacitor and a discharging circuit, and then flows into an inert gas lamp. | 2021-11-18 |
20210353818 | SYSTEM AND METHOD FOR PROTECTING A WORKSPACE FROM AIRBORNE CONTAMINANTS - A system for protecting a workspace from airborne contaminants comprises at least one sensing capturing unit, an air transmission unit, an air capturing unit, and a processor. The processor is configured to receive a sensing data associated with the workspace from the at least one sensing capturing unit and determine presence of at least one source of transmission of the airborne contaminants. The processor is further configured to configure a capture zone within the workspace based on the determined at least one source of transmission of the airborne contaminants. The processor is configured to control the air transmission unit to direct a unidirectional flow of air over the configured capture zone, thereby directing movement of the airborne contaminants in the capture zone and further to control the air capturing unit to capture the unidirectional flow of air, along with the airborne contaminants, directed from the air transmission unit. | 2021-11-18 |
20210353819 | METHOD AND APPARATUS FOR PURIFYING AIR OF AN INTERIOR SPACE BY OXIDIZING A PLURALITY OF POLLUTANT COMPOUNDS - Embodiments generally relate to a method for purifying air of an interior space by oxidizing a plurality of pollutant compounds suspended in the air. The method comprises exposing the air of the interior space to a photocatalytic layer, wherein the photocatalytic layer is disposed onto an at least one surface of a porous substrate material located in the interior space, wherein the photocatalytic layer comprises a plurality of photocatalyst particles, and activating the photocatalytic layer with a light source, wherein the activated photocatalytic particles promote a reaction between the pollutant compounds and the air. | 2021-11-18 |
20210353820 | FAN SYSTEM FOR IMPROVING INDOOR AIR QUALITY AND RELATED METHODS - A system for minimizing exposure of at least one occupant to a pathogen and for circulating air within a space is provided. The system includes a fan for circulating air within the space. At least one sensor for sensing a parameter within the space is provided. A controller is configured for determining a risk of exposure to the pathogen based on the sensed parameter within the space and to alter operation of the fan and/or a source of germicidal energy, such as a UV light, based on the determined risk of exposure. Related methods are also disclosed. | 2021-11-18 |
20210353821 | Filament having cellulose fibers with non resorbable features less radio pacifier - The filament and suture products disclosed are to be implanted in the body, having non re sorbable ingredients with absorbent qualities to disperse an antibiotic and strong enough to hold tissue securely but flexible enough to be printed or knotted. The products are biocompatible and consist of two dissimilar polymers having unmelted cellulose fiber. These dissimilar polymers and the unmelted fibers are densified by compression and the removal of moisture having fiber orientation and alignment, showing low levels of radiopacity. These products will have radiopacity in household units (HU) ranging from −200 to 200 HU and produce meshes, bone grafts, scaffolds or wound care products where bone bridging can be observed. | 2021-11-18 |
20210353822 | THREAD EMBEDDING THERAPY ROPE AND THREAD EMBEDDING THERAPY NEEDLE APPARATUS COMPRISING SAME - The present invention relates to a thread embedding therapy rope and a thread embedding therapy needle apparatus comprising same, and disclosed are a thread embedding therapy rope and a needle apparatus comprising same, the rope comprising a linear core, which comprises a biodegradable polymer, and a metal wire, which is arranged to spirally encompass the outer circumferential surface of the linear core, wherein the metal wire comprises a biodegradable metal formed with magnesium or zinc as a main component, so as to have no side effects on biological tissue when applied to the human body by means of thread embedding therapy, pulling force on the tissue can be strengthened, lifespan can be extended over that of a conventional embedded thread of a biodegradable polymer, the drug loading capability of the embedded thread itself can be increased so as to allow for usefulness as a drug carrier, and a drug can be delivered through a simple method. | 2021-11-18 |
20210353823 | DENDRIMER-BIOADHESIVE POLYMER HYDROGEL NANOGLUE AND USE THEREOF - A nanoglue is formed with one or more bioadhesive polymers, one or more dendrimers, and optionally one or more therapeutic, prophylactic, or diagnostic agents. The bioadhesive polymers and dendrimers are modified with functional groups to permit crosslinking upon one or more stimuli, e.g., ultraviolet irradiation, and form hydrogel in situ at tissue sites. In the repair of corneal wounds, the nanoglue leads to improved rate of healing with less scarring and less inflammation, compared to non-treated cornea or ones treated with sutures. Therapeutic agents can be covalently conjugated to the precursor components and be delivered to specific eye compartments, providing a more efficacious treatment formulation of ocular disorders than delivering drugs in their free forms. Methods of making and using the hydrogel and hydrogel precursor compositions are also provided. | 2021-11-18 |
20210353824 | FIDGETIN-LIKE 2 SIRNA-ENHANCED POLOXAMER-BASED HYDROGEL FOR WOUND HEALING - Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer. | 2021-11-18 |
20210353825 | SCALABLE THREE-DIMENSIONAL ELASTIC CONSTRUCT MANUFACTURING - Tissue repair and restoration can be performed using an elastic material formed from tropoelastin. The elastic material can be formed by providing a solution of tropoelastin monomers, applying the solution to a surface, and heating the solution on the surface in absence of a cross-linking agent to enable the tropoelastin monomers to bind to each other to form an elastic material that does not dissociate into tropoelastin monomers when the elastic material is contacted with an aqueous solution. | 2021-11-18 |
20210353826 | IONIC POLYMER COMPOSITIONS - The present disclosure pertains to ionic polymer compositions, including semi- and fully interpenetrating polymer networks, methods of making such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging for such articles. | 2021-11-18 |
20210353827 | MATERIAL FOR BONE IMPLANTS AND METHOD OF PRODUCING SAME - The present invention relates to a material for bone implants, comprising: a surface of oxidic ceramic materials, titanium or polyether ether ketone (PEEK) or other polymer or composite materials, a matrix of collagen or gelatin, which is covalently bound to said surface, and calcium phosphate embedded into said matrix. The present invention further relates to a method for producing the material according to the invention, to bone implants comprising the material according to the invention, and to its use as a bone implant material. | 2021-11-18 |
20210353828 | MICROCAPILLARY NETWORK BASED SCAFFOLD - A scaffold is provided, the scaffold comprising: at least one inlet tube; at least one outlet tube; and a plurality of porous elongated microtubes, wherein each one of said porous elongated microtube has an inner diameter of 5-100 micrometers, wherein said plurality of elongated microtubes extend from said at least one inlet tube to said at least one outlet tube and is in fluid communication thereto, Further provided is a method for producing and using the scaffold, such a s for tissue engineering. | 2021-11-18 |
20210353829 | BIOADHESIVE FOR CORNEAL REPAIR - The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea. | 2021-11-18 |
20210353830 | INTERPENETRATING NETWORKS WITH COVALENT AND IONIC CROSSLINKS - The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer. | 2021-11-18 |
20210353831 | SCAFFOLDING FOR IMPLANTABLE MEDICAL DEVICES AND METHODS OF USE THEREOF - Scaffolding constructs, medical devices comprising scaffolding constructs, and related methods of manufacturing and treatment are described. The scaffolding construct may comprise a biocompatible material, such as a polymer, copolymer, or hydrogel. The scaffolding construct may be porous and at least partially bioresorbable. Further, for example, the scaffolding construct may define a cavity for securing a medical implant therein. | 2021-11-18 |
20210353832 | OXYGEN-GENERATING BIODEGRADABLE SURGICAL MESH - The present disclosure relates to a novel oxygen-generating biodegradable surgical mesh, and to methods of making and using the novel oxygen-generating biodegradable surgical mesh. More specifically, a novel surgical mesh has been developed, wherein the surgical mesh has a flexible basic structure and comprises a plurality of pores, wherein the surgical mesh has a first face and a second opposite face, wherein the surgical mesh is made of a substantially homogeneous material comprising a biodegradable polymeric material and an oxygen-generating material. | 2021-11-18 |
20210353833 | NERVE REPAIR SCAFFOLDS HAVING HIGH MICROCHANNEL VOLUME AND METHODS FOR MAKING THE SAME - Tissue scaffolds for neural tissue growth have a plurality of microchannels disposed within a sheath. Each microchannel comprises a porous wall having a thickness of ≤about 100 μm that is formed from a biocompatible and biodegradable material comprising a polyester polymer. The polyester polymer may be polycaprolactone, poly(lactic-co-glycolic acid) polymer, and combinations thereof. The tissue scaffolds have high open volume % enabling superior (linear and high fidelity) neural tissue growth, while minimizing inflammation near the site of implantation in vivo. In other aspects, methods of making such tissue scaffolds are provided. Such a method may include mixing a reduced particle size porogen with a polymeric precursor solution. The material is cast onto a template and then can be processed, including assembly in a sheath and removal of the porogen, to form a tissue scaffold having a plurality of porous microchannels. | 2021-11-18 |
20210353834 | THREE DIMENSIONAL ELECTROSPUN BIOMEDICAL PATCH FOR FACILITATING TISSUE REPAIR - A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue. | 2021-11-18 |
20210353835 | BIODEGRADABLE ZINC-BASED MATERIALS INCLUDING DISPERSED NANOSTRUCTURES FOR BIOMEDICAL APPLICATIONS - A biomedical device includes a zinc-based material including a matrix including zinc, and nanostructures dispersed in the matrix. Embodiments of this disclosure are directed to zinc (Zn)-based materials including dispersed nanostructures for biomedical applications and devices, such as bioresorbable vascular stents, bioresorbable ureteral stents, endoluminal springs for distraction enterogenesis, biodegradable bone implants with tunable modulus, guided bone generation membranes, bioresorbable dental membranes, and other biomedical implants, as well as other functional applications, such as biodegradable electronics and sensors. | 2021-11-18 |
20210353836 | BIOABSORBABLE STENT - Provided are a magnesium alloy stent with improved corrosion resistance, and a method for producing same. The bioabsorbable stent including a core structure of a magnesium alloy, the stent is composed of: a first anticorrosive layer containing magnesium fluoride as a main component formed on the core structure, and a second anticorrosive layer coated with a diamond-like carbon on the first anticorrosive layer. | 2021-11-18 |
20210353837 | SCREEN EXCHANGE DEVICE, BIOLOGICAL TISSUE SIZE REDUCTION SYSTEM COMPRISING SAME, BIOLOGICAL TISSUE SIZE REDUCTION METHOD USING SAME, AND METHOD FOR SEPARATING TARGET SUBSTANCE FROM RELEVANT BIOLOGICAL TISSUE - A screen exchange device for reducing the size of a biological tissue according to one embodiment comprises: a disk comprising a plurality of screens each having at least one through-hole configured to reduce the size of a biological tissue, the screens having different through-hole characteristics; a first cover which covers a first side of the disk and includes a first opening through which a biological tissue passes; a second cover which covers a second side of the disk and includes a second opening through which the biological tissue passes; a housing configured to receive the disk; and a manipulator which selects any one screen among the plurality of screens and manipulates the first cover or the second cover such that the selected screen communicates with the first opening and the second opening. | 2021-11-18 |
20210353838 | ALGORITHM FOR UTILIZING MULTIPLE INPUTS TO MODULATE THE CHARGING RATE OF A FULLY IMPLANTABLE SYSTEM - A controller implantable within the body of a patient as part of a left ventricular assist device (LVAD) system and a method therefore are provided. According to one aspect, the controller includes processing circuitry configured to receive inputs from at least one of: at least one internal component of the LVAD system, at least one external component of the LVAD system, and at least one clinician's device, and determine a charging rate for charging a battery of the LVAD system internal to the patient based on at least one of the received inputs. | 2021-11-18 |