47th week of 2015 patent applcation highlights part 21 |
Patent application number | Title | Published |
20150329433 | ENVIRONMENT-FRIENDLY SLOW-RELEASE SULFUR-BASED NITROGEN POTASSIUM COMPOUND FERTILIZER - Provided is an environment-friendly slow-release sulfur-based nitrogen potassium compound fertilizer. The preparation includes first preparing sulfur-based nitrogen potassium compound fertilizer granules, and then conducting primary coating of stearic acid and secondary surface powder dusting of modified zeolite powder on the sulfur-based nitrogen potassium compound fertilizer granules, to obtain the slow-release sulfur-based nitrogen potassium compound fertilizer. The sulfur-based nitrogen potassium compound fertilizer granules are prepared from the following raw materials in parts by weight: 31 to 57 parts of urea, 10 to 20 parts of ammonium sulfate, 20 to 50 parts of potassium sulfate, 6 to 12 parts of a granulating auxiliary agent, and a proper amount of water. | 2015-11-19 |
20150329434 | Use of synergistic microorganisms and nutrients to produce signals that facilitate the germination and plant root colonization of mycorrhizal fungi in phosphorus rich environments - A composition of matter comprising: a combination of a phytate and a plurality of microorganisms comprising a | 2015-11-19 |
20150329435 | COMBINED ANIMAL REPELLANT AND FERTILIZER COMPOSITION - A composition, as a liquid or spreadable solids, combines an effective amount of a fertilizer, preferably urea and potassium sulfate or potassium chloride, and an effective amount of an animal repellant, preferably a minimum-risk pesticide product, with a liquid carrier, preferably water, or a spreadable solid carrier. | 2015-11-19 |
20150329437 | Pyrotechnics Containing Oleoresin - A pyrotechnic composition includes a fuel, an oxidizer, flow and rate control agents and oleoresin capsicum as an irritant. The composition is useful in crowd control products. The composition contains rate control ingredients to maintain combustion at a temperature below the point of degradation of the oleoresin capsicum, balanced with a booster material to maintain combustion. | 2015-11-19 |
20150329438 | ETHYLENE-TO-LIQUIDS SYSTEMS AND METHODS - Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products. | 2015-11-19 |
20150329439 | ETHYLENE-TO-LIQUIDS SYSTEMS AND METHODS - Integrated systems are provided for the production of higher hydrocarbon compositions, for example liquid hydrocarbon compositions, from methane using an oxidative coupling of methane system to convert methane to ethylene, followed by conversion of ethylene to selectable higher hydrocarbon products. Integrated systems and processes are provided that process methane through to these higher hydrocarbon products. | 2015-11-19 |
20150329440 | LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME (As Amended) - This disclosure relates to a novel ligand compound that can oligomerize ethylene with high catalyst activity and selectivity, a catalyst system for olefin oligomerization including the same, and a method for olefin oligomerization using the same. | 2015-11-19 |
20150329441 | Operation of Modified HF Alkylation Unit - An HF alkylation process for producing gasoline boiling range alkylate product by the alkylation in an HF alkylation unit of a light olefin reactant with an isoparaffin reactant in the presence of a hydrogen fluoride/sulfolane alkylation catalyst mixture in which fresh sulfolane feed having a Total Acid Number (TAN, ASTM D974) not more than 2 mq./L and optimally not more than 1 meq./L. is added to the hydrogen fluoride/sulfolane alkylation catalyst circulating in the unit. Control over the acidic components of the sulfolane feed is appropriately maintained by monitoring and pretreatment with an ion exchange resin to remove acidic components from the feed. | 2015-11-19 |
20150329442 | RECOVERY OPTIONS FOR n-BUTANE DEHYDROGENATION FOR ON-PURPOSE BUTADIENE PRODUCTION - A process for the production of butadiene is presented. The process converts a butane stream through dehydrogenation to process stream having butenes. The butenes are treated and separated from the process stream to generate an olefin rich stream. The olefin rich stream is passed to an oxydehydrogenation reactor for conversion to butadienes. The process utilizes a cold-box separation process for efficiently separating the process stream generated through dehydrogenation to separate light gases from the C4 hydrocarbon stream. | 2015-11-19 |
20150329443 | REID VAPOR PRESSURE CONTROL PROCESS - A process for removing cyclopentene from the C | 2015-11-19 |
20150329444 | CATALYTIC DISPROPORTIONATION OF PENTANE USING IONIC LIQUIDS - Processes for the disproportionation and isomerization of a C | 2015-11-19 |
20150329445 | PROCESS FOR RECOVERING HYDROCARBONS FROM POLYOLEFIN PLANTS AND APPARATUS SUITABLE FOR THIS PURPOSE - Disclosed herein is a method and apparatus for recovering hydrocarbons from polyolefin plants. A method of the present disclosure includes introducing a hydrocarbon-containing inert gas from a residual monomer separation unit of a polyolefin plant into a condensation and separation device, condensing hydrocarbons from a hydrogen-containing inert gas in the condensation and separation device, separating the condensed inert gas into a condensed hydrocarbon-containing product and purified inert gas in the device, and sending the condensed hydrocarbon-containing product to a downstream further separation device for removal of dissolved gasses therefrom. A device of the present disclosure includes a condensation and separation device for condensing hydrocarbons from an inert gas and separating condensed hydrocarbon-containing inert gas into a condensed hydrocarbon-containing product and a purified inert gas, and a further separation device connected downstream for purifying the condensed hydrocarbon-containing product originating from the condensation and separation device by separating off dissolved gases. | 2015-11-19 |
20150329446 | TWO STAGE CONTACT COOLER - An apparatus and process is disclosed for the cooling of a reactor effluent gas stream. The apparatus includes a two stage contact cooling system with a first stage wash zone and second stage wash zone. Each wash zone has a packed bed, or other type of mechanical system for contacting the gas stream with the cooling liquid. The liquid in the first stage will remove heavy components, allowing for a cleaner second stage that can be reduced in size. | 2015-11-19 |
20150329447 | PREPARATION OF BROMINE-CONTAINING AROMATIC COMPOUNDS AND THEIR APPLICATION AS FLAME RETARDANTS - The invention relates to compounds of the formula Ar(—CH2C6Br5)y, wherein Ar indicates a structure comprising one or more six-membered aromatic ring(s) and —CH | 2015-11-19 |
20150329448 | METHOD FOR PREPARING AN ANHYDROSUGAR ALCOHOL USING HYDROL - The present invention relates to a method for preparing an anhydrosugar alcohol using hydrol (namely, a crystalline mother liquor remaining after obtaining crystalline glucose from a crude glucose liquor). More particularly, the present invention relates to a method for preparing an anhydrosugar alcohol in a method for performing a dehydration reaction on the hydrogenated sugar so as to convert the hydrogenated sugar to an anhydrosugar alcohol, wherein the method for preparing an anhydrosugar alcohol is configured to use, as at least a portion of the hydrogenated sugar, the product obtained from the hydrogenation of the hydrol which is a by-product or waste generated during the production of glucose, thus relatively lowering the cost for a material as compared with a case of using a high purity raw material (for example, high purity sorbitol), to thus improve economical advantages, and further reduce the amount of waste and cost for disposal of the waste during the production of glucose. | 2015-11-19 |
20150329449 | PROCESS FOR THE CONTINUOUS PRODUCTION OF ETHYLENE GLYCOL FROM CARBOHYDRATES - A continuous process for converting carbohydrates to ethylene and propylene glycol. The carbohydrates are mixed with water and passed through a reactor at a temperature that hydrolyzes the carbohydrate mixture at least partially to monosaccharides. The reactor has a first zone comprising a retro-aldol catalyst and a second zone comprising a reducing catalyst. The aldose is converted in the first zone into glycolaldehyde by the retro-aldol catalyst and the glycolaldehyde, in the presence of hydrogen, is converted to ethylene glycol in the second zone of the reactor. The reaction products are removed from the reactor and the ethylene glycol is recovered. The selectivity to propylene glycol can be enhanced via feeding ketose as the carbohydrate. | 2015-11-19 |
20150329450 | INTEGRATED PROCESS FOR THE PRODUCTION OF METHANOL AND METHYL ACETATE - An integrated process for the production of methyl acetate and methanol by carbonylating dimethyl ether with synthesis gas, recovering a methyl acetate stream and an unreached synthesis gas stream comprising methyl acetate, scrubbing the synthesis gas to remove methyl acetate and passing the scrubbed synthesis gas for methanol synthesis. | 2015-11-19 |
20150329451 | SYNTHESIS OF TETRAHYDROMYRCENOL - The present invention relates to a new and improved synthesis of tetrahydromyrcenol (IUPAC name: 2,6-dimethyl-2-octanol). | 2015-11-19 |
20150329452 | METHOD FOR PRODUCING OPTICALLY ACTIVE ISOPULEGOL AND OPTICALLY ACTIVE MENTHOL - A method for producing an optically active isopulegol includes asymmetrically isomerizing a specific compound in the presence of a ruthenium catalyst and a base, thereby giving an optically active citronellal, and selectively cyclizing the optically active citronellal in the presence of an aluminum catalyst. The aluminum catalyst is obtained by reacting a specific hydroxy compound and at least one aluminum compound selected from a specific alkylaluminum compound, a specific hydride aluminum compound, a specific linear aluminoxane and a specific cyclic aluminoxane. | 2015-11-19 |
20150329453 | PROCESS FOR THE ALKOXYLATION OF (PER) FLUOROPOLYETHER ALCOHOLS - A convenient process for the manufacture of alkoxylated derivatives of PFPE alcohols is herein provided. The process envisages the use of a boron-based catalyst and an iodine source and is characterised in that a PFPE alkoxide is prepared separately, contacted with a boric acid triester of the same PFPE alcohol and finally submitted to alkoxylation in the presence of an iodine source. The process allows achieving an alkoxylation degree of at least 2 with high yields and under conditions that are convenient on an industrial scale. | 2015-11-19 |
20150329454 | POLYETHER DIOL AND METHOD FOR PRODUCING THE SAME - A method for producing a polyether diol includes the step of subjecting a compound represented by the following general formula (1) to hydrogenation reduction in the presence of a hydrogenation catalyst to provide a specific polyether diol. | 2015-11-19 |
20150329455 | Alpha,Alpha-Difluoroacetaldehyde Production Method - A production method of α,α-difluoroacetaldehyde according to the present invention includes reaction of an α,α-difluoroacetic acid ester with hydrogen gas (H | 2015-11-19 |
20150329456 | (6R,10R)-6,10,14-TRIMETYLPENTADECAN-2-ONE PREPARED FROM 6,10,14 TRIMETYLPENTADECA-5,9,13-TRIEN-2-ONE OR 6,10,14-TRIMETYLPENTADECA-5,9-DIEN-2-ONE - The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product. | 2015-11-19 |
20150329457 | (6R,10R)-6,10,14-TRIMETYLPENTADECAN-2-ONE PREPARED FROM 6,10-DIMETYLUNDEC-5-EN-2-ONE OR 6,10-DIMETYLUNDECA-5,9-DIEN-2-ONE - The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product. | 2015-11-19 |
20150329458 | METHOD FOR SYNTHESIS OF LACTIC ACID AND ITS DERIVATIVES AND CATALYST FOR PREPARING SAME - The present disclosure provides a catalyst for preparing lactic acid and derivatives thereof, comprising at least one of metallic compounds MX | 2015-11-19 |
20150329459 | HETEROGENEOUSLY CATALYZED CHEMICAL REDUCTION OF CARBON DIOXIDE - The presently disclosed and/or claimed inventive concept(s) relates generally to the reduction of carbon dioxide by heterogeneous catalysis. More particularly, but not by way of limitation, the presently disclosed and/or claimed inventive concept(s) relates to the reduction of carbon dioxide by heterogeneous catalysis with a heterogeneous hydrogenation catalyst comprising structurally frustrated Lewis pairs, wherein, for example but not by way of limitation, formic acid is produced and hydrocarbons are indirectly produced. In one non-limiting embodiment, the heterogeneous catalyst comprises hexagonal boron nitride (h-BN) having structurally frustrated Lewis pairs therein. | 2015-11-19 |
20150329460 | PROCESS FOR THE PREPARATION OF ADIPIC ACID - The invention relates to a process for the preparation of adipic acid from adipic acid alkyl ester comprising:
| 2015-11-19 |
20150329461 | METHODS FOR SEPARATING MIXTURES OF FATTY ACIDS - The invention provides methods for separating mixtures of two or more fatty acids. | 2015-11-19 |
20150329462 | Purification Of Bio Based Acrylic Acid To Crude And Glacial Acrylic Acid - Processes for the purification of bio-based acrylic acid to crude and glacial acrylic acid are provided. The bio-based acrylic acid is produced from hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof. The purification includes some or all of the following processes: extraction, drying, distillation, and melt crystallization. The produced glacial or crude acrylic acid contains hydroxypropionic, hydroxypropionic acid derivatives, or mixtures thereof as an impurity. | 2015-11-19 |
20150329463 | PROCESS FOR THE PREPARATION OF INGENOL-3-ANGELATE FROM 20-DEOXY-INGENOL - The present invention provides a method for preparing ingenol-3-angelate. | 2015-11-19 |
20150329464 | CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID CHLORIDE - The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol. | 2015-11-19 |
20150329465 | INTEGRATED PROCESS FOR THE PRODUCTION OF METHYL ACETATE AND METHANOL FROM SYNTHESIS GAS AND DIMETHYLETHER - An integrated process for the production of methyl acetate and methanol by the carbonylating dimethyl ether with synthesis gas, recovering methyl and unreacted synthesis gas and wherein the recovered synthesis gas is utilized as the sole fresh synthesis gas for methanol synthesis. | 2015-11-19 |
20150329466 | INTEGRATED PROCESS FOR THE PRODUCTION OF METHANOL AND METHYL ACETATE - An integrated process for the production of methyl acetate and methanol by carbonylating dimethyl ether with synthesis gas, recovering methyl acetate and unreacted synthesis gas and supplying unreacted synthesis gas and fresh synthesis gas for methanol synthesis. | 2015-11-19 |
20150329467 | FLUORINE ATOM-CONTAINING PHENOL COMPOUND - A phenol compound is represented by formula (1) (in formula (1), R | 2015-11-19 |
20150329468 | Method for the synthesis of alpha/alpha-prime-alcoxylated glycerol linear carbonic esters - A method for the synthesis of α/α′-alcoxylated glycerol linear carbonic esters, wherein the following are brought into contact at a reaction temperature lower than 220° C.: a quantity of at least one precursor selected from the group consisting of α/α′-alcoxylated glycerol cyclo-carbonates; a quantity of at least one catalyst selected from the group consisting of metal oxides, Lewis acids, organometallic catalysts and mineral bases; and a quantity of at least one organic primer. A composition containing at least one novel α/α′-alkoxylated glycerol linear carbonic ester. | 2015-11-19 |
20150329469 | SEPARATION METHOD FOR DINITROTOLUENE AND MIXED ACID IN A TOLUENE TO DINITROTOLUENE PROCESS - Proposed is a separation method in a toluene to dinitrotoluene process, wherein said method with a first process step comprising feeding a toluene comprising first stream ( | 2015-11-19 |
20150329470 | DEHYDROXYLATION OF NITROALCOHOLS TO NITROALKANES - The present invention provides a process for producing nitroalkanes by dehydroxylation of nitroalcohols. This provides an alternate reaction route for making nitroalkanes, such as 2-nitropropane and its derivatives. | 2015-11-19 |
20150329471 | DEHYDROXYLATION OF AMINOALCOHOLS TO ALKYL AMINES - The present invention provides a process for producing alkyl amines by dehydroxylation of aminoalcohols. This provides an alternate reaction route for making alkyl amines, such as 2-methylpropane-2-amine and its derivatives. | 2015-11-19 |
20150329472 | HALOGENATED ANILINE AND METHOD FOR PRODUCING SAME - The present invention provides a halogenated aniline represented by formula (I) (wherein each of X | 2015-11-19 |
20150329473 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS - Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | 2015-11-19 |
20150329474 | AMINE COMPOUND AND IONIC CONDUCTIVE AGENT, AND ELECTROCONDUCTIVE RESIN COMPOSITION - An amine compound and an ionic conductive agent excellent in electroconductivity are provided. By using the amine compound, an electroconductive resin composition suppressed in bleeding and excellent in electroconductivity is provided. The amine compound and the ionic conductive agent have a structure represented by the following general formula (1). | 2015-11-19 |
20150329475 | QUATERNARY AMMONIUM HYDROXIDES - A composition including (a) a quaternary ammonium hydroxide having a general formula (I): | 2015-11-19 |
20150329476 | ETHERAMINES BASED ON 1,2-DIALCOHOLS - The invention relates to etheramines of formula (I) or formula (II) or a mixture of etheramines of formula (I) and formula (II) based on 1,2-dialcohols, wherein R | 2015-11-19 |
20150329477 | CONTINUOUS METHOD FOR SEPARATING SALTS IN THE PRODUCTION OF DIMETHYLACETAMIDE - What is proposed is a continuous process for discharging a solid, salt-containing phase comprising alkali metal acetates and/or alkaline earth metal acetates from the product mixture from the preparation of N,N-dimethylacetamide (DMAC) by reaction of methyl acetate (MeOAc) with dimethylamine (DMA) in the presence of a catalyst comprising N,N-dimethylacetamide (DMAC), methyl acetate (MeOAc), dimethylamine (DMA) and a catalyst, having the following process steps:
| 2015-11-19 |
20150329478 | ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF - The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic | 2015-11-19 |
20150329479 | Process for the production of aminopropylmethylethanolamine - A new process for the production of APMMEA (aminopropylmethylethanolamine) is proposed. This process comprises at least 2 steps in which MEAPN (monomethylethanolaminopropionitrile) is first produced from MMEA (monomethylethanol amine) and ACN (acrylonitrile) and then said MEAPN is hydrogenated to obtain the corresponding amine, the APMMEA compound. APMMEA may be then eventually purified by several known process, notably by distillation. | 2015-11-19 |
20150329480 | ON-LINE ANALYSIS OF ACRYLONITRILE PRODUCT - An apparatus comprises a first controller configured to control at least the flow rate of a polymerization inhibitor or acrylonitrile product to a first location where the two are mixed. The apparatus comprises a first on-line analyzer configured to measure polymerization inhibitor concentration in the acrylonitrile product at a second location, the second location downstream of the first location. The first on-line analyzer is configured to provide information relating to the measured inhibitor concentration at the second location to the first controller, the first controller configured process the information from the first on-line analyzer and to adjust at least a first operating parameter of a first addition device if the measured inhibitor concentration at the second location is outside a first predetermined condition. A second controller and a second on-line analyzer are provided to provide similar control of water addition to acrylonitrile product. | 2015-11-19 |
20150329481 | METHIONINE ANALOGS AND METHODS OF USING SAME - Provided are methionine analogs which may be useful for inhibiting protein synthesis, inhibiting microbial growth and/or treating infectious diseases. In some instances, the analogs exhibit bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and/or antiviral properties. Also provided are methods of treatment and methods of preparation, as well as kits and unit dosages. | 2015-11-19 |
20150329482 | Preparation of 13-Cyclohexyl-3-Methoxy-6-[Methyl-(2-(2-[Methyl-(Sulphamoyl)-Amino]-Ethox- y}-Ethyl)-Carbamoyl]-7H-Indolo-{2,1-a]-[2]-Benzazepine-10-Carboxylic Acid - The present invention relates to an improved method for the preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid. The present invention also relates to a new compound, namely tent-butyl (methyl-{2-[2-(methylamino)-ethoxy]-ethyl}-sulphamoyl)-carbamate, used in this improved method. | 2015-11-19 |
20150329483 | Methods and Pharmaceutical Compositions for the Treatment of X-Linked Charcot-Marie-Tooth - The present invention relates to methods and pharmaceutical compositions for the treatment of X-linked Charcot-Marie-Tooth. In particular, the present invention relates to a method for the treatment of CMTX in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an inhibitor of CamKII activity or expression. | 2015-11-19 |
20150329484 | ESTER HAVING SULPHONE GROUP - Esters having at least one sulphone group on the acid chain, processes for preparation thereof and use of the ester as a plasticizer for polymers. | 2015-11-19 |
20150329485 | METHOD FOR PRODUCING BIS(3-AMINOPHENYL)DISULFIDES AND 3-AMINOTHIOLS - The present invention relates to a novel method for preparing bis(3-aminophenyl)disulphides of the general formula (I) and 3-aminothiols of the general formula (II), | 2015-11-19 |
20150329486 | Carbondisulfide Derived Zwitterions - Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability. | 2015-11-19 |
20150329487 | Improved Synthesis Of Succinimides And Quaternary Ammonium Ions For Use In Making Molecular Sieves - The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves. | 2015-11-19 |
20150329488 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 2015-11-19 |
20150329489 | SAXAGLIPTIN SALTS - The present invention provides saxagliptin bisulphate, saxagliptin acetate, saxagliptin oxalate, saxagliptin bicarbonate, and saxagliptin carbonate, their polymorphic forms, processes for their preparation, and pharmaceutical compositions thereof. | 2015-11-19 |
20150329490 | CYANINE DYE COMPOUND AND PREPARATION METHOD THEREFOR, AND DUAL-FUNCTION AGENT FOR PHOTODYNAMIC THERAPY AND PREPARATION METHOD THEREFOR - Disclosed are a cyanine dye compound and a preparation method therefor, and a dual-function agent for photodynamic therapy and a preparation method therefor. The provided cyanine dye compound is connected to multiple markers, which improves the accuracy of combination of dye and tumor cells, effectively reduces the background value, and avoids excessive residues in the liver. The provided cyanine dye compound is conjugated with the photosensitizer at 2′″ position, so that tumor highly absorbs the conjugates. | 2015-11-19 |
20150329491 | FLUORENE COMPOUND AND PHARMACEUTICAL USE THEREOF - The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: | 2015-11-19 |
20150329492 | THERMALLY ROBUST, HIGHLY POROUS, AND PARTIALLY FLUORINATED ORGANIC FRAMEWORK WITH AFFINITY FOR HYDROCARBONS, FLUOROCARBONS AND FREONS - Porous partially fluorinated materials which bind aliphatic and aromatic hydrocarbons, fluorocarbons and freons with high weight adsorption capacities are provided. Such compounds may be used in separation of materials by exclusion such as selective separation of isomers of xylene. | 2015-11-19 |
20150329493 | OMEGA-AMINO ACID DERIVATIVES OF BENZENE, PYRIDINE, AND PYRIDAZINE COMPOUNDS - Disclosed are compounds and pharmaceutically acceptable salts of Formula I | 2015-11-19 |
20150329494 | Process for Preparing Asymmetrical Imidazolium Salts - The invention relates to a process for preparing an asymmetrical imidazolium salt of formula (1A), in which R1 is an aromatic group, R2 is chosen from a cyclic secondary aliphatic alkyl group and a heteroalkyl group, R3 and R4 are chosen, independently of one another, from the group consisting of hydrogen, a halide and an alkyl group, and A″ is an anion. The process comprises a fast substep of forming a reaction mixture by bringing one equivalent of an aniline into contact with one equivalent of a compound bearing an amine group, in the presence of at least four point five equivalents of a Brønsted acid. The process also comprises a second substep of forming a solution comprising one equivalent of a dicarbonyl, one equivalent of formaldehyde, and at least four point five equivalents of the Brønsted acid, and adding thereto the reaction mixture formed in the first substep. The mixture is left to stir for a predetermined time at a predetermined temperature. The intermediate asymmetrical imidazolium salt 1A is then isolated. | 2015-11-19 |
20150329495 | PYRIDAZINONES AS DAAO ENZYME INHIBITORS - The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, | 2015-11-19 |
20150329496 | Cdc42 INHIBITOR AND USES THEREOF - Compounds which inhibit the small G protein Rho GTPase cell division cycle protein Cdc42 are provided. Morphological analyses of filopodia, western blots of Ccd42 phosphorylation, and effects on cellular wound healing and on growth cone formation all demonstrate that the described compounds are able to inhibit all tested Cdc42-mediated processes. The compounds effectively inhibit the effects of Cdc42 and effectively Cdc42-related cellular functions involving actin, such as Golgi organization and cell movement. Furthermore, the described Cdc42 inhibitor compounds may be provided as a medicament for the treatment of various conditions. | 2015-11-19 |
20150329497 | SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1 - Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. | 2015-11-19 |
20150329498 | IRAK INHIBITORS AND USES THEREOF - The present invention provides quinazoline and quinoline compounds, compositions thereof, and methods of using the same. Also disclosed is the activity of such compounds as inhibitors of IRAK enzymes. | 2015-11-19 |
20150329499 | 6-SUBSTITUTED QUINAZOLINONE INHIBITORS - The present technology relates to compounds and compositions of Formulas I-III and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of diseases associated with an alphavirus, for example, Venezuelan equine encephalitis virus (VEEV). | 2015-11-19 |
20150329500 | SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS - The invention provides a chemical entity of Formula (I) | 2015-11-19 |
20150329501 | SUBSTITUTED [1,2,4]TRIAZOLE COMPOUNDS AND THEIR USE AS FUNGICIDES - The present invention relates to compounds of the formula I | 2015-11-19 |
20150329502 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS - Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases. | 2015-11-19 |
20150329503 | SUBSTITUTED BENZAMIDES AND THEIR USES - Provided herein are Substituted Benzamides, compositions, and method of their manufacture and use. | 2015-11-19 |
20150329504 | NOVEL BETA-ALANINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT - The present invention relates to a beta-alanine derivative, pharmaceutically acceptable salts thereof, and a pharmaceutical composition including the same as an active ingredient. The novel beta-alanine derivative and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, to thereby be effectively used as a pharmaceutical composition for preventing or treating various lipid metabolism-related disorders selected from the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis. | 2015-11-19 |
20150329505 | A FLUORESCENT COMPOSITION FOR USE IN MARKING OBJECTS, SUCH AS FLOWERS - The present invention relates to a fluorescent composition, comprising polycyclic aromatic fluorophores, and its use in marking objects, such as plants. The composition may be applied to the surface of the plant or it can be taken up by the plant providing luminescent flower. | 2015-11-19 |
20150329506 | 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION - Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: (I) wherein R | 2015-11-19 |
20150329507 | PROCESSES FOR THE PREPARATION OF ENAMINES - The invention disclosed in this document is related to the field of processes for the preparation of enamines | 2015-11-19 |
20150329508 | Processes for the Preparation of Enamines - The invention disclosed in this document is related to the field of processes for the preparation of enamines | 2015-11-19 |
20150329509 | PROCESSES FOR THE PREPARATION OF ENAMINES - The invention disclosed in this document is related to the field of processes for the preparation of enamines | 2015-11-19 |
20150329510 | CARRIER TREATMENT TO IMPROVE CATALYTIC PERFORMANCE OF AN ETHYLENE OXIDE CATALYST - A method for lowering the sodium content of different carriers which may have different physical properties as well as varying degrees of sodium is provided. The method, which lowers the sodium content from the surface, subsurface as well as the binding layer of the carrier, includes contacting a carrier with water. A rinse solution is recovered from the contacting. The rinse solution includes leached sodium from the carrier. The sodium content in the rinse solution is then determined. The contacting, recovering and determining are repeated until a steady state in the sodium content is achieved. | 2015-11-19 |
20150329511 | METHOD OF SYNTHESIS OF SUBSTITUTED HEXITOLS SUCH AS DIANHYDROGALACTITOL - The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C. to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t-butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. Another method produces dianhydrogalactitol from dulcitol; this method comprises: (1) reacting dulcitol with a reactant to convert the 1,6-hydroxy groups of dulcitol to an effective leaving group to generate an intermediate; and (2) reacting the intermediate with an inorganic weak base to produce dianhydrogalactitol through an intramolecular S | 2015-11-19 |
20150329512 | METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATING LUNG CANCER - The present invention is related to a method and pharmaceutical composition for treating lung cancer. The pharmaceutical composition comprises an effective amount of 16-hydroxy-cleroda-3,13-dine-15,16-olide as active ingredient, and a pharmaceutically acceptable carrier. The present method and pharmaceutical composition provides good efficacy in treating lung cancer even for drug-resistance patient. The present invention also establishes an animal model bearing human lung cancer, which provides a better drug screening platform for the research. | 2015-11-19 |
20150329513 | LARGE MOLECULE AND POLYMER FLAME RETARDANTS - Disclosed herein are flame retardant compounds and polymer compositions containing these flame retardant compounds. The flame retardant compounds can be derived from biological sources and can include coordinated metal ions. | 2015-11-19 |
20150329514 | Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Appliance, and Lighting Device - An organic compound that emits blue light with high color purity and has a long lifetime is provided as a novel substance. The organic compound is a fluorescent organic compound having a structure in which benzonaphthofuranylamine is bonded to the 1-position and the 6-position of a pyrene skeleton. | 2015-11-19 |
20150329515 | COMPOSITION AND METHOD FOR TREATING OR PREVENTING INFLUENZA VIRUS INFECTION - The present invention provides a pharmaceutical composition and method for treating or preventing influenza virus infection in a subject comprising administering the subject with a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of compounds provided in this invention. In addition, the prevent invention provides new compounds for treating or preventing influenza virus infection. | 2015-11-19 |
20150329516 | DEVICE AND METHOD FOR SEPARATING A CYCLIC DIESTER FROM POLYMER MELTS - The present invention relates to a device and also to a method for separating and recovering a cyclic diester, in particular dilactide or glycolide from polymer melts which include the cyclic diester as impurity. The device and also the method according to the invention allow recovery of the cyclic diester with a high yield and at the same time high purity. | 2015-11-19 |
20150329517 | TETRAHYDRONAPHTHYL(THIO) CARBOXAMIDES - The present invention relates to novel tetrahydronaphthyl(thio) carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials | 2015-11-19 |
20150329518 | THERAPEUTIC PROSTAGLANDIN RECEPTOR AGONISTS - Described herein are compounds which can be used in topical liquids, creams, or other dosage forms such as solids, for reducing intraocular pressure, treating glaucoma, growing hair, treating wounds, or other medical and/or cosmetic uses. | 2015-11-19 |
20150329519 | Formulations Comprising Lipoyl Compounds - Provided herein are aqueous pharmaceutical formulations comprising monomeric lipoyl compounds, such as compounds of Structural Formula I: | 2015-11-19 |
20150329520 | CONJUGATES AND ASSOCIATED METHODS OF PRODUCING THEM FOR THE PREVENTION OR TREATMENT OF NICOTINE ADDICTION - The present invention relates in part to chemical compounds, and methods for producing these compounds. The compounds may also be incorporated into compositions to enhance quit rates or reduce relapse in smoking cessation and further in treating nicotine-related dependence. | 2015-11-19 |
20150329521 | PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS - The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans. | 2015-11-19 |
20150329522 | MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS - The present invention relates to novel melanocortin receptor antagonist compounds corresponding to the general formula (I) below: | 2015-11-19 |
20150329523 | KINASE INHIBITORS - In compounds of formula I: | 2015-11-19 |
20150329524 | FATTY ACID SYNTHASE INHIBITORS - This invention relates to triazolones and triazolones for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of triazolones in the treatment of cancer. | 2015-11-19 |
20150329525 | PYRROLIDINE-2, 5-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE AS IDO1 INHIBITORS - The present invention relates to compound of Formula I | 2015-11-19 |
20150329526 | PROCESS FOR THE PREPARATION OF PAZOPANIB OR SALTS THEREOF - The present invention provides a process for the preparation of pazopanib of Formula Ia or salts, and intermediates thereof. | 2015-11-19 |
20150329527 | PYRAZOLE LINKED BENZIMIDAZOLE CONJUGATES AND A PROCESS FOR PREPARATION THEREOF - Pyrazole linked benzimidazole conjugates and a method for synthesis of one or more compounds having a pyrazole linked benzimidazole conjugate, particularly pyrazole linked benzimidazole conjugates that are useful as potential antitumor agents against human cancer cell lines, such as leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer. The process comprises the step of oxidative cyclization of o-phenylenediamines and 3-phenyl-1H-pyrazole-5-carbaldehydes with sodium metabisulphite in ethanol/methanol solvent system at a desired temperature for a period of time to obtain the pyrazole linked benzimidazole conjugate. | 2015-11-19 |
20150329528 | Pladienolide Pyridine Compounds and Methods of Use - The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. | 2015-11-19 |
20150329529 | CARBOXAMIDE DERIVATIVES - The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; | 2015-11-19 |
20150329530 | ANTIBACTERIAL COMPUNDS - The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates, deuterated forms and prodrugs thereof. Also provided is the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture. | 2015-11-19 |
20150329531 | AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS - The invention provides certain amino-pyrimidine-containing compounds. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase. | 2015-11-19 |
20150329532 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES - The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades. | 2015-11-19 |
20150329533 | COMPOUNDS CAPABLE OF INHIBITING VOLTAGE GATED CALCIUM ION CHANNEL, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME - Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect. | 2015-11-19 |