47th week of 2015 patent applcation highlights part 25 |
Patent application number | Title | Published |
20150329834 | METHODS OF PROPAGATING MONKEY ADENOVIRAL VECTORS - The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods. | 2015-11-19 |
20150329835 | BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF - The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof. | 2015-11-19 |
20150329836 | SPECIFIC INTERNALIZATION OF NANOPARTICLES INTO PROTEIN CAGES - The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG. | 2015-11-19 |
20150329837 | ENGINEERED BIOCATALYSTS AND METHODS FOR SYNTHESIZING CHIRAL AMINES - The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents. | 2015-11-19 |
20150329838 | TRANSAMINASE BIOCATALYSTS - The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 2015-11-19 |
20150329839 | METHODS FOR INCREASING GRAIN YIELD - Compositions and methods for increasing heat resistance or starch biosynthesis in plants are provided herein. Polynucleotides, polypeptides, and expression constructs for expressing mutant AGPase subunit proteins, plants comprising the polynucleotides, polypeptides or expression constructs, and methods of producing transgenic plants are also provided. | 2015-11-19 |
20150329840 | Novel Gene From Tidal Flat Metagenome And a Novel Protein Displaying Both Phospholipase And Lipase Activities - The present invention relates to a novel gene derived from a tidal flat metagenome, and a novel protein obtained therefrom showing the coactivity of phospholipase and lipase. Specifically, the novel gene isolated from the metagenome library of tidal flat sediments and the protein having phospholipase and lipase activities encoded from the novel gene: are expressed in a water-soluble form to be mass-producible; enable ultra high-purity protein to be obtained through single step purification using an Ni-NTA column; show good activity in the pH range of 5˜10; maintain good low temperature activity and stability up to a temperature of 3° C. to 40° C.; and have high resistance against various organic solvents. Therefore, the novel gene and the protein can be usefully used for various industrial fields such as the purification and conversion of oil and fat, bio-medicine, and fine chemistry. | 2015-11-19 |
20150329841 | CELLULOSE-DEGRADING ENZYME COMPOSITION COMPRISING GH16 - The present invention relates to a cellulose-degrading enzyme composition comprising one or more cellobiohydrolase and/or endoglucanase enzyme, and an effective amount of an isolated GH16 polypeptide, where the presence of the isolated GH16 polypeptide in the enzyme composition increases the rate or extent of degradation of a cellulosic substrate compared to an equivalent dosage of a corresponding cellulose-degrading enzyme composition lacking the at least one isolated GH16 polypeptide. The present invention also relates to a method for producing fermentable sugars from a cellulosic substrate using the above cellulose-degrading enzyme composition and to genetically modified microbes for produced the above cellulose-degrading enzyme composition. | 2015-11-19 |
20150329842 | COMPOSITIONS AND METHODS COMPRISING CELLULASE VARIANTS WITH REDUCED AFFINITY TO NON-CELLULOSIC MATERIALS - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions. | 2015-11-19 |
20150329843 | HOST CELL CAPABLE OF PRODUCING ENZYMES USEFUL FOR DEGRADATION OF LIGNOCELLULOSIC MATERIAL - The invention relates to a host cell comprising at least four different heterologous polynucleotides chosen from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filamentous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be used in a process for the saccharification of cellulosic material. | 2015-11-19 |
20150329844 | Polypeptides Having Protease Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having protease activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2015-11-19 |
20150329845 | COMPOSITIONS, METHODS, AND KITS FOR PREPARING PLASMINOGEN; AND PLASMIN PREPARED THEREFROM - Compositions and methods for preparing plasminogen, in particular recombinant plasminogen, and compositions and methods of utilizing same for preparing plasmin are provided. | 2015-11-19 |
20150329846 | Recombinant Elastase Proteins and Methods of Manufacturing and Use Thereof - The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention. | 2015-11-19 |
20150329847 | FUSION PROTEIN COMPRISING GRANZYME B AND USE THEREOF - A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein. | 2015-11-19 |
20150329848 | CELL CULTURE MEDIUM FOR ADAMTS PROTEIN EXPRESSION - The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein. | 2015-11-19 |
20150329849 | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS - Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided. | 2015-11-19 |
20150329850 | Generating Targeted Sequence Diversity in Proteins - Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same. | 2015-11-19 |
20150329851 | BINDING A TARGET SUBSTANCE - Magnetic particles capable of binding a target substance, which comprise a magnetic material and a matrix material, wherein the magnetic material is remanent upon exposure to a magnetic field and the matrix material has a surface comprising functional groups which promote disaggregation of the particles in the presence of a liquid phase. | 2015-11-19 |
20150329852 | INCREASING DYNAMIC RANGE FOR IDENTIFYING MULTIPLE EPITOPES IN CELLS - The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection. | 2015-11-19 |
20150329853 | COMPOSITIONS AND METHODS FOR CREATING ALTERED AND IMPROVED CELLS AND ORGANISMS - The present invention provides compositions comprising randomized in-frame fusion polynucleotides and methods for introducing them into a host organism to identify desirable phenotypic changes that disrupt or alter existing genetic or biochemical mechanisms or pathways, thus creating novel characteristics of the transformed organism. Methods for using the compositions for increasing diversity within populations of organisms are also presented. | 2015-11-19 |
20150329854 | METHOD OF SYNTHESIS OF GENE LIBRARY USING CODON RANDOMIZATION AND MUTAGENESIS - Proposed is a method of easily finding an error during analysis of various library sequences of nucleic acid base sequences after synthesizing a gene library using a combination of three nucleic acid base sequences (codon) translated into the same protein. This shows that it is possible to create a gene library having the same protein sequence but different nucleic acid base sequences. The present disclosure provides a novel experimental method capable of measuring a correlation between gene expression according to change in a codon by changing the usage of a codon optimized to express a specific gene in vivo. | 2015-11-19 |
20150329855 | AMPLIFICATION PRIMERS AND METHODS - The present invention provides methods, compositions, and kits for performing amplification (e.g., whole genome amplification) employing primers that have a 5′ restriction site, a 3′ random sequence (e.g., a random hexamer), and an identifiable barcode sequence. In certain embodiments, the amplification generates individual amplified sequenced that are ligated together to form concatamers containing at least two amplified sequences (e.g., not contiguous on the original target sequence) that are separated by the barcode sequences. In particular embodiments, a plurality of the concatamers are sequenced and aligned with an alignment algorithm that uses the barcode sequences to identify artificial junctions between amplified sequences. | 2015-11-19 |
20150329856 | METHODS AND SYSTEMS FOR THE GENERATION OF A PLURALITY OF SECURITY MARKERS AND THE DETECTION THEROF - This invention pertains to methods for generating large quantities of DNA security markers by combinatorial variation techniques using polymorphic fragment length DNA for unique identification security marker applications such as explosive ink used in dye/smoke pack and cash carrying boxes. | 2015-11-19 |
20150329857 | RNA INTERFERENCE TO ACTIVATE STEM CELLS - The present invention relates to the use of interferent RNAs that silence PW1 expression in order to activate adult stem cells in vitro or in vivo, in particular in the context of regenerative medicine. | 2015-11-19 |
20150329858 | LONG NON-CODING RNA USED FOR ANTICANCER THERAPY - The present invention provides a novel long non-coding RNA (lncRNA), which is induced by β-catenin and highly expressed in cancer, a nucleic acid that suppresses expression of the lncRNA, a means for promoting or suppressing cell growth by using the lncRNA or the nucleic acid, and the like. | 2015-11-19 |
20150329859 | SELECTIVE REDUCTION OF ALLELIC VARIANTS - Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative diseases, such as Huntington's Disease (HD). | 2015-11-19 |
20150329860 | GENE SILENCING - The present invention relates to transcriptional gene silencing (TGS) of endogenes in plants, plant tissue and plant cells. More specifically, the present invention relates to nucleic acid constructs that are capable of more effectively silencing genes of interest, such as endogenes, in plants, plant tissue and plant cells by TGS. The present invention further relates to methods of more effectively reducing endogenous gene expression in plants, plant tissues or plant cells by TGS using the nucleic acid constructs of the invention. | 2015-11-19 |
20150329861 | MIRNA MODULATORS OF THERMOGENESIS - Provided are novel methods and compositions for the modulation of thermogenesis. Such methods are particularly advantageous in that they allow for the reduction of body fat in a subject without the subject having to adjust their caloric intake through dieting, modify their physical activity or undergo bariatric surgery. Accordingly, the methods of the invention are particularly useful for treating or preventing obesity. Also provided are methods of screening for novel agents that modulate the activity of thermogenic regulators. | 2015-11-19 |
20150329862 | Gene Silencing by Single-Stranded Polynucleotides - The present invention relates to compositions and methods for concurrently activating antisense and double-stranded RNase (dsRNase) mechanisms for inhibiting expression of a targeted gene, by delivering a single stranded bifunctional chimeric DNA/RNA oligonucleotide optimized for siRNA activity as well as antisense activity, into the nucleus of a target cell. | 2015-11-19 |
20150329863 | APTAMERS INHIBITING THE ENZYMATIC ACTIVITY OF TYROSINASE - The invention relates to a DNA aptamer that can inhibit the enzymatic activity of tyrosinase for the conversion of tyrosine into L-DOPA and dopaquinone, and to the dermatological and cosmetic uses thereof. | 2015-11-19 |
20150329864 | DESIGN OF OLIGONUCLEOTIDE ANALOGS AS THERAPEUTIC AGENTS - The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the compounds of the invention can be used as antiviral agents, anticancer agents and so on. In certain embodiments, the compounds of the invention can modulate immune-stimulatory pathways and non-TLR pathways. The invention also relates to design modified oligonucleotides for therapeutic applications, by excluding nucleotide segments having off-target effects from the modified oligonucleotides. In another aspect, the invention provides pharmaceutical compositions including one or more compounds of the invention. | 2015-11-19 |
20150329865 | COMPOSITION FOR TREATING EPSTEIN-BARR VIRUS INFECTION, COMPRISING EPSTEIN-BARR VIRUS MICRO RNA INHIBITOR - Provided is a composition comprising an Epstein-Barr virus microRNA inhibitor for treating Epstein-Barr virus infection, and a method using Epstein-Barr virus microRNA for screening a therapeutic agent for treating Epstein-Barr virus infection. The provided composition enables one to induce the lytic cycle of EBV such that EBV-infected cells are destroyed by a host immune system. Therefore, the composition can be effectively used for the prevention or treatment of diseases, including various cancers, caused by EBV infection. Moreover, the provided method enables one to screen a therapeutic agent having excellent antiviral effect for treating Epstein-Barr virus infection by inducing Epstein-Barr virus lytic cycle. | 2015-11-19 |
20150329866 | NOVEL siRNAS AND METHODS OF USE THEREOF - The invention relates to compounds, in particular siRNAs, which inhibit the expression of specific human genes. The invention also relates to pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. The present invention also provides a method of treating and/or preventing the incidence or severity of various diseases or conditions associated with the genes and/or symptoms associated with such diseases or conditions comprising administering to a subject in need of treatment for such disease or condition and/or symptom the compound or the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the subject. The invention also provides antibodies which inhibit specified human polypeptides and pharmaceutical compositions comprising one or more such antibodies. | 2015-11-19 |
20150329867 | Pharmaceutical Compositions and Diagnostic Methods for Inflammatory Skin Diseases, Disorders or Conditions - The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis. | 2015-11-19 |
20150329868 | MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR CONTINUOUS PRODUCTION OF CARBON-CONTAINING COMPOUNDS - The present invention relates to a continuous production system for producing carbon-containing compounds, comprising a genetically modified photosynthetic microorganism, such as a | 2015-11-19 |
20150329869 | SYNTHETIC PROMOTER CONSTRUCT FOR TRANSGENE EXPRESSION - The invention is directed to synthetic promoter constructs for enhanced transgene expression in plants and to expression cassettes comprising the synthetic promoter constructs. The expression cassettes may include various elements for improved expression, stability of the expressed protein or efficient purification of the expressed protein, including signal sequences, protease cleavage sites for release of the target protein, trafficking peptides for trafficking of the expressed protein to various plant compartments, and/or various tags. The invention further relates to methods of expression of transgenic proteins in plants with the use of the synthetic promoter constructs and expression cassettes. | 2015-11-19 |
20150329870 | Methods for Elevating Fat/Oil Content in Plants - In some embodiments, the present invention provides a method of elevating lipid content in vegetative (non-seed) plant or algal cells, plant tissues, or whole plants by genetically modifying the plant or algae to express a protein or polypeptide associated with lipid metabolism (such as fat-specific protein 27) of animal origin or plant origin. Also provided are genetically-modified plant or algal cells, plant tissues, or whole plants with elevated cellular lipid content, expressing a protein or polypeptide associated with lipid metabolism (such as fat-specific protein 27) of animal (e.g. human) origin or plant origin. | 2015-11-19 |
20150329871 | GENE CAPABLE OF INCREASING PLANT BIOMASS PRODUCTION AND METHOD FOR UTILIZING THE SAME - This invention is intended to increase biomass production through suppression of expression of a gene functioning in relation to intracellular vesicular transport or inhibition of functions of a protein encoded by such gene. To this end, expression of a gene encoding the coatomer adapter zeta subunit is suppressed, the coatomer adapter zeta subunit is inhibited, expression of a gene encoding the clathrin adaptor small (sigma) subunit is suppressed, or the clathrin adaptor small (sigma) subunit is inhibited. | 2015-11-19 |
20150329872 | EXPRESSION CASSETTE - The present invention provides an expression cassette comprising ( | 2015-11-19 |
20150329873 | FURIN-KNOCKDOWN AND GM-CSF-AUGMENTED (FANG) CANCER VACCINE - Compositions and methods for cancer treatment are disclosed herein. More specifically the present invention describes an autologous cancer vaccine genetically modified for Furin knockdown and GM-CSF expression. The vaccine described herein attenuates the immunosuppressive activity of TGF-β through the use of bi-functional shRNAs to knock down the expression of furin in cancer cells, and to augment tumor antigen expression, presentation, and processing through expression of the GM-CSF transgene. | 2015-11-19 |
20150329874 | VACCINE PREPARED UTILIZING HUMAN PARAINFLUENZA VIRUS TYPE 2 VECTOR - Disclosed are: a virus vector in which a gene encoding an antigenic polypeptide is integrated in human parainfluenza virus type 2 gene, wherein the antigenic polypeptide is expressed in the form of a fusion protein with a viral structural protein; and a method for producing the same. The virus vector of the present invention contains a quantitatively large amount of the antigenic peptide on the virus particle and can efficiently deliver the antigenic polypeptide to a target cell. | 2015-11-19 |
20150329875 | METHODS AND COMPOSITIONS FOR PREVENTION OR TREATMENT OF A DISEASE - Methods and compositions for treatment of a genetic disease are provided. | 2015-11-19 |
20150329876 | NUTRIENT COMBINATION, PROCESS AND SYSTEM FOR ENHANCING BIOGENIC METHANE PRODUCTION FROM A CARBONACEOUS MATERIAL - A nutrient combination for enhancing biogenic methane production from a carbonaceous material is described. The nutrient combination comprises a source of phosphorus (P) and gaseous nitrogen (N | 2015-11-19 |
20150329877 | FERMENTATION METHOD - Describes is a fermentation method for producing a hydrocarbon compound comprising the culturing of an organism in a liquid fermentation medium, wherein said organism produces a desired hydrocarbon compound by an enzymatic pathway, said enzymatic pathway comprising an intermediate which evaporates into the gaseous phase and wherein said intermediate is recovered from the gaseous phase and is reintroduced into the liquid fermentation medium. | 2015-11-19 |
20150329878 | FERMENTATIVE PRODUCTION OF A HYDROCARBON - The present invention relates to a process for the fermentative production of a hydrocarbon, wherein a microorganism producing the hydrocarbon is cultured in a liquid fermentation medium in a fermenter, wherein an inlet gas comprising oxygen is fed into the fermenter and the total pressure of the inlet gas before introduction into the fermenter is about 1.5 bar to about 15 bar (about 150 kPa to about 1500 kPa), wherein the hydrocarbon is obtained in a gaseous state in the fermentation off-gas, and wherein the concentration of oxygen in the fermentation off-gas is controlled to be below about 10 vol-%. The process is particularly cost effective, eliminates or reduces the risk of inflammation of the fermentation off-gas, and facilitates the isolation of the hydrocarbon from the fermentation off-gas. | 2015-11-19 |
20150329879 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials, to proceed ethanol and/or butanol, e.g., by fermentation. | 2015-11-19 |
20150329880 | VARIANT CBH I POLYPEPTIDES WITH REDUCED PRODUCT INHIBITION - The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides. | 2015-11-19 |
20150329881 | MICROORGANISM HAVING NOVEL ACRYLIC ACID SYNTHESIS PATHWAY AND METHOD OF PRODUCING ACRYLIC ACID BY USING THE MICROORGANISM - A microorganism capable of producing an acrylic acid (AA), wherein activities of a pathway producing AA through conversions of 3-HP to 3-HP-CoA and 3-HP-CoA to AA-CoA in the microorganisms are increased; as well as a method of producing the microorganism and a method of producing an acrylic acid by using the same. | 2015-11-19 |
20150329882 | MICROORGANISM HAVING ENHANCED PRODUCTIVITY OF SUCCINATE AND METHOD OF PRODUCING SUCCINATE USING THE SAME - Provided is a recombinant microorganism comprising an exogenous pyruvate dehydrogenase E1 protein, and/or increased expression of alpha-ketoglutarate dehydrogenase E1. | 2015-11-19 |
20150329883 | GENETICALLY ENGINEERED BACTERIAL CELL AND METHOD OF PRODUCING SUCCINIC ACID USING THE SAME - Provided are a genetically engineered bacterial cell and a method of producing succinic acid by using the cell. | 2015-11-19 |
20150329884 | PROCESS OF PRODUCING A LACTATE FERMENT - The present invention relates to fermentation processes. The objective of the invention was to provide methods for producing ferments and formulating such ferments into preservatives. It was in particular an object of the present invention to provide improved processes for producing lactic acid containing ferments by simple and efficient (batch) culturing and allowing for simple down-stream processing either into a liquid, semi-liquid or a dry powder product, having sufficient stability, good handling properties and satisfactory organoleptic properties. Such processes are provided, as well as the products that can be obtained with it and their use as food preservative. | 2015-11-19 |
20150329885 | MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING ADIPATE, 6-AMINOCAPROATE, HEXAMETHYLENEDIAMINE OR CAPROLACTAM RELATED THERETO - Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. | 2015-11-19 |
20150329886 | ISOLATED PEDIOCOCCUS ACIDILACTICI 05B0111 AND METHOD OF PRODUCING EXOPOLYSACCHARIDE - Disclosed herein is an isolated | 2015-11-19 |
20150329887 | INTEGRATED BIOREFINERY - This invention relates to the operation of a biorefinery for manufacturing either biofuels or renewable chemical feedstock using lignocellulosic biomass as a source of carbon. The present invention provides a cost-effective process for pretreating lignocellulosic biomass in the recovery of fermentable sugars. More specifically, the present invention describes an integrated approach for efficiently recovering and using six-carbon and five-carbon sugars along with value-added oligosaccharides such as xylooligosaccahrides from lignocellulosic biomass so that the cost of manufacturing biofuels and renewable chemical feedstock is substantially lowered. | 2015-11-19 |
20150329888 | PROCESS FOR THE PRODUCTION OF SOLUTIONS OF SUGARS AND ALCOHOLS FROM LIGNOCELLULOSIC BIOMASS WITH COMPLEMENTARY TREATMENT OF SOLID RESIDUE WITH A HYDRATED INORGANIC SALT - The present invention describes a process for the production of solutions of sugars and alcohols from lignocellulosic biomass, comprising a pre-treatment, a step for enzymatic hydrolysis and alcoholic fermentation, a step for extraction of the alcohol produced, a step for separation of the solid residue, an optional step for washing and drying, followed by a step for digestion of the solid residue in a medium comprising at least one hydrated inorganic salt with formula MX | 2015-11-19 |
20150329889 | PROCESS FOR ENZYMATIC HYDROLYSIS OF CELLULOSE - Cellulose from lignocellulosic biomass which also contains protein, such as grasses and straws, can be enzymatically converted to valuable products such as glucose at lower enzyme consumption by: (a) extracting the biomass with water at 15-75° C. to produce an extracted biomass and a protein-containing aqueous extract; (b) mechanically, chemically and/or thermally pretreating cellulose-containing-biomass, in particular by organosolv treatment; and (c) contacting biomass pretreated in step (b) with: (i) an enzyme capable of hydrolysing cellulose; and (ii) the protein-containing aqueous extract obtained in step (a). | 2015-11-19 |
20150329890 | ERROR CORRECTION IN NUCLEIC ACID MOLECULES - An enzymatic method for removing sequence errors in nucleic acid molecules are described. The method utilizes a CEL endonuclease that cuts heteroduplexes at mismatch sites containing the errors and an overlap extension polymerase chain reaction to re-assemble the cleaved fragments into full-length nucleic acid molecules free of the errors. | 2015-11-19 |
20150329891 | ANALYSIS OF NUCLEIC ACIDS ASSOCIATED WITH SINGLE CELLS USING NUCLEIC ACID BARCODES - Provided herein are methods and compositions for analyzing nucleic acids associated with single cells using nucleic acid barcodes. According to some embodiments, a method for producing one or more polynucleotides of interest comprises: obtaining a plurality of RNAs associated with one or more samples, wherein the samples are obtained from one or more subjects, each RNA is associated with a single sample, and the RNAs associated with each sample are present in a separate reaction volume; adding an adapter molecule to the RNAs associated with each sample, wherein the adapter molecule is generated using an enzymatic reaction and comprises a universal priming sequence, a barcode sequence, and a binding site; and incorporating the barcode sequence into one or more polynucleotides associated with each sample, thereby producing the one or more polynucleotides of interest. | 2015-11-19 |
20150329892 | Apparatus and Method for Optical Sampling in Miniature Bioprocessing Vessels - An optical sampling apparatus for miniature-scale bioprocessing vessels includes features for optical interrogation of the bioprocessing vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the bioprocessing vessels during bioprocesses. Multiple such bioprocessing vessels with the optical interrogation features may be mounted in a receiver for conducting multiple bioprocesses simultaneously. A translatable probe may be used to interact with each of the bioprocessing vessels in the receiver. | 2015-11-19 |
20150329893 | DEVICE DESIGNED TO RECEIVE A BIOLOGICAL SAMPLE - Device designed to receive at least one biological sample, said device comprising:
| 2015-11-19 |
20150329894 | MICROBIOLOGICAL SYSTEMS AND METHODS OF FLUID SAMPLE ANALYSIS - Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and detecting the presence of a target microorganism. Methods may be used with an automated detection system. | 2015-11-19 |
20150329895 | Methods of Determining Cell Mediated Response - The invention relates to the use of one of more biomarkers, such as granzyme B, to determine an immune response, such as a cell-mediated immune response, of a subject to an immunostimulatory composition. The invention also relates to methods of treating a subject determined to develop a poor immune response to an immunostimulatory composition. Further, the invention relates to kits for use in practicing methods of the invention. | 2015-11-19 |
20150329896 | N-END RULE PROTEASE ACTIVITY INDICATION METHODS AND USES THEREOF - A cell based assay for detection for protease activity is disclosed. In the assay a cell is engineered to express a protease substrate with at least one label, preferably on its C-terminus. Cleavage of the substrate by the protease that recognizes it results in a C-terminal fragment and a N-terminal fragment, where the fragment having the label is subject to ubiquitin proteasome degradation. The assay measures the disappearance of the label due to degradation of the fragment to which it is attached. A cell free assay is also described for detection of protease activity. In the cell free assay, the protease substrate is expressed in a solution that includes the elements of the ubiquitin proteasome pathway for degradation of the fragment. The assay measures the disappearance of the label attached to the fragment that results from cleavage by the protease. | 2015-11-19 |
20150329897 | MICRO-ORGANISM DETECTION MEDIUM COMPRISING AT LEAST ONE ALKYL(THIO)GLYCOSIDE - A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising:
| 2015-11-19 |
20150329898 | Mate-Pair Sequences from Large Inserts - This disclosure describes modified methods and compositions of matter pertaining to mate pair sequencing. In an implementation of the invention, mate pair sequence data is generated without cloning in a host system. In an implementation of the invention, a nucleic acid fragment is ligated into a vector. The vector containing the inserted nucleic acid fragment is digested with a restriction endonuclease that cuts at two or more places on the insert but does not cut the vector. Following the restriction endonuclease digest, the vector with portions of the nucleic acid fragment remaining after the restriction endonuclease digestion is again ligated. This ligation connects the cut ends of the insert to each other. The re-ligated product may be sequenced to obtain sequence data for both a “right” and “left” side of the originally inserted nucleic acid fragment. | 2015-11-19 |
20150329899 | SYSTEMS AND METHODS FOR VALIDATION OF SEQUENCING RESULTS - Systems and method for validation of sequencing results can amplify a target region of a nucleic acid sample in the presence of a primer pool including target specific and variant specific primers. The variant specific primers can include variant specific barcodes and variant specific sequences. An amplicon can be sequenced to determine the sequence of the variant specific barcode. The variant can be identified based on the sequence of the variant specific barcode, and the location of the variant can be determined by mapping the amplicon to a reference sequence. | 2015-11-19 |
20150329900 | Nucleic Acid Amplification Method - The invention relates to a method of performing a helicase dependent amplification (HDA) or thermophilic helicase dependent amplification of a template nucleic acid comprising: (i) combining in a reaction mixture the template nucleic acid; a forward and a reverse HDA primer; a helicase; at least one DNA polymerase and deoxynucleotide triphosphates (dNTPs), (ii) wherein the reaction comprises a linear polyethylene glycol with the formula | 2015-11-19 |
20150329901 | Method and System for Decontaminating Materials - Methods, systems, and devices for decontaminating materials containing biological or biologically derived materials, such as microorganisms or DNA products, are provided. The methods, systems, and devices may be used for decontaminating or sterilizing materials, such as surfaces, including, but not limited to reducing the number of viable microorganisms on surfaces. The methods, systems, and devices may further be used for rendering DNA non-amplifiable in nucleic acid amplification reactions that synthesize DNA amplification products. | 2015-11-19 |
20150329902 | PRODUCTION OF CLOSED LINEAR DNA - An in vitro process for the production of closed linear deoxyribonucleic acid (DNA) comprises (a) contacting a DNA template comprising at least one protelomerase target sequence with at least one DNA polymerase in the presence of one or more primers under conditions promoting amplification of the template; and (b) contacting amplified DNA produced in (a) with at least one protelomerase under conditions promoting production of closed linear DNA. A kit provides components necessary in the process. | 2015-11-19 |
20150329903 | PREDICTING RESISTANCE TO DISEASE - The Invention relates to a method of predicting resistance to infectious pancreatic necrosis in salmon, the method comprising determining the alleles present at a DNA polymorphism in the salmon and predicting whether or not the salmon is resistant to infectious pancreatic necrosis based on the determination of the alleles. The invention also relates to a method of selecting a salmon for use as broodstock, wherein the salmon is selected based on the prediction by the first method that the salmon will have resistance to infectious pancreatic necrosis. | 2015-11-19 |
20150329904 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2015-11-19 |
20150329905 | SENSOR ARRAYS AND NUCLEIC ACID SEQUENCING APPLICATIONS - Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction cavities containing sensors to monitor changes in solutions contained in the reaction cavities. Additional embodiments provide devices and methods for sequencing DNA using arrays of reaction cavities that allow for optical monitoring of solutions in the reaction cavities. Test and fill reaction schemes are disclosed that allow DNA to be sequenced. By sequencing DNA using parallel reactions contained in large arrays, DNA can be rapidly sequenced. | 2015-11-19 |
20150329906 | NOVEL GENOME SEQUENCING STRATEGIES - The invention relates to a method for the determination of a genome sequence comprising the steps of providing a physical map of a sample genome by sequencing fragment ends of pooled BAC clones; providing a set of sequence reads from a sample genome generating a contig of the physical map and the sequence reads. | 2015-11-19 |
20150329907 | BIOMARKERS AND TREATMENTS FOR HEART FAILURE - The invention features methods to predict the response to a cardiac therapy in a patient suffering from a cardiac disease, e.g., heart failure. The invention features measurement expression of biomarkers that help in this prediction. The invention also features methods for treatment of cardiac diseases. These methods include cardiac resynchronization therapy and miRNA based therapeutics. | 2015-11-19 |
20150329908 | Pattern Recognition Receptor Expression As a Measure of Systemic Health - The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more Pattern Recognition Receptors including but not limited to Toll Like Receptors, myeloid differentiation primary response gene 88 (MyD88), and Nucleotide Binding oligomerization domain containing protein 1 (NOD1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition. The described methods enable evaluation of the systemic health of the animal afflicted with an oral health condition by measuring expression levels of the indicated genes as compared to suitable controls. | 2015-11-19 |
20150329909 | AUTISM-ASSOCIATED BIOMARKERS AND USES THEREOF - The invention discloses biomarkers for human autism. The invention provides methods for treating, preventing, and diagnosing human autism and autism-related disorders. | 2015-11-19 |
20150329910 | Methods of Detecting Diseases or Conditions Using Phagocytic Cells - This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to identify markers of diseases or conditions. | 2015-11-19 |
20150329911 | NUCLEIC ACID BIOMARKERS FOR PROSTATE CANCER - This invention relates to microRNA biomarkers useful in the diagnosis and prognosis of prostate cancer. The biomarkers are also useful for the monitoring and/or treatment of prostate cancer. | 2015-11-19 |
20150329912 | BIOMARKERS IN CANCER, METHODS, AND SYSTEMS RELATED THERETO - This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the disclosure relates to methods for diagnosing pro-state cancer, methods of distinguishing between less aggressive and high aggressive prostate cancer, methods of determining predisposition to recurrence of prostate cancer, methods of monitoring progression/regression of prostate cancer, methods of assessing efficacy of compositions for treating prostate cancer, and methods of screening compositions for activity in modulating biomarkers of prostate cancer. | 2015-11-19 |
20150329913 | Identification of a 5-Gene Expression Signature Predicting Clinical Outcome of Patients with Brain Tumors - High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly tumorigenic cellular subpopulations that fuel tumor aggressiveness. Identification of the molecular mechanisms remains elusive. Therefore, there is a need for diagnostic markers to accurately determine the type of glioma and appropriate treatment. Gene delivery vehicles are provided that comprise an oncogene, IRES-Cre-ER cassette and a gene encoding an oligonucleotide that inhibits p53 including shp53. Methods are also provided for determining a diagnosis and for treatment of non-aggressive and aggressive gliomas. | 2015-11-19 |
20150329914 | PREDICTIVE BIOMARKERS FOR PRE-MALIGNANT BREAST LESIONS - The invention is based on the discovery of biomarkers and gene signatures that are useful for determining the presence of atypical hyperplasia in a breast lesion, and for determining whether a pre-malignant breast lesion is likely to progress to breast cancer. In particular, the present invention provides methods and reagents for detecting and profiling the expression levels of these biomarkers and genes, and methods of using the expression profiles for predicting the likelihood that a pre-malignant lesion will progress to breast cancer. | 2015-11-19 |
20150329915 | COMPOSITIONS AND METHODS FOR CLASSIFYING THYROID NODULE DISEASE - A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue. | 2015-11-19 |
20150329916 | METHODS AND KITS USED IN CLASSIFYING ADRENOCORTICAL CARCINOMA - The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients. | 2015-11-19 |
20150329917 | Method for Monitoring Disease Progression or Recurrence - The invention provides methods for detecting and monitoring diseases associated with genetic abnormalities in a subject. | 2015-11-19 |
20150329918 | JAGGED1 AS A MARKER AND THERAPEUTIC TARGET FOR BREAST CANCER BONE METASTASIS - A method of treating Jagged1 induced bone metastasis is provided. A method of analyzing patients with tumors insensitive to RANK targeting treatments, but may respond to Jagged1 or Notch targeting therapies is provided. A method of treating patients with Jagged1 induced bone metastasis is provided. A method of predicting the therapeutic of treating a cancer patient with bone metastasis is provided. A kit for treating patients with Jagged1 induced bone metastasis is provided. A kit for predicting the therapeutic outcome of treating a cancer patient with bone metastasis using RANKL inhibitors is provided. | 2015-11-19 |
20150329919 | USE OF MiR-26 FAMILY AS A PREDICTIVE MARKER FOR HEPATOCELLULAR CARCINOMA AND RESPONSIVENESS TO THERAPY - Provided is a method of selecting a patient diagnosed with HCC as a candidate for IFN-α therapy, by detecting the level of microRNA-26 expression in a sample obtained from the patient. | 2015-11-19 |
20150329920 | AMPLIFICATION AND SEQUENCING OF TRANSRENAL NUCLEIC ACIDS - The present invention provides highly sensitive methods used for diagnosing and monitoring various diseases and disorders by detecting and analyzing “ultra short” (20-50 base pair) nucleic acids obtained from bodily fluids. | 2015-11-19 |
20150329921 | DETERMINING TUMOR ORIGIN - The disclosure provides methods for the use of gene expression measurements to classify or identify among 54 cancer types in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples. | 2015-11-19 |
20150329922 | CORN EVENT 5307 - A novel transgenic corn event designated 5307, is disclosed. The invention relates to DNA sequences of the recombinant constructs inserted into the corn genome and of genomic sequences flanking the insertion site that resulted in the 5307 event. The invention further relates to assays for detecting the presence of the DNA sequences of event 5307, to corn plants and corn seeds comprising the genotype of and to methods for producing a corn plant by crossing a corn plant comprising the event 5307 genotype with itself or another corn variety. | 2015-11-19 |
20150329923 | EXOPOLYSACCHARIDE-PRODUCING BACTERIA, AND USES THEREOF FOR PROTECTING HEART HEALTH - An isolated | 2015-11-19 |
20150329924 | Method for Carbonation - The present application discloses a method for carbonation with CO | 2015-11-19 |
20150329925 | METHOD FOR RECOVERING SACCHARIDE FROM SACCHARIFIED SLURRY, AND WASHING DEVICE FOR WASHING RESIDUE - A saccharide recovering method for recovering saccharides from a saccharified slurry obtained after subjecting a slurry of cellulosic biomass to a hot water treatment and to provide a washing device for washing a saccharified slurry residue suited for conducting such a saccharide recovery method is provided. Saccharified slurry of cellulosic biomass is fed on a conveyor having a net conveyor belt, the saccharified slurry is dehydrated, washing water is sprayed to dissolve saccharides remaining in the residue into the washing liquid. The residue is washed by a plurality of washing water spraying units disposed in series in such a manner that the moving direction of the residue and the moving direction of the washing water are opposite to each other. The washing water having washed the residue is used as washing water for washing water spraying unit in the direction opposite to the moving direction of the conveyor. | 2015-11-19 |
20150329926 | SACCHARIFIED SOLUTION PRODUCTION METHOD AND SACCHARIFIED SOLUTION PRODUCTION APPARATUS THAT USE CELLULOSIC BIOMASS AS STARTING MATERIAL - A saccharified solution production method includes: a saccharifying step of saccharifying hemicellulose or cellulose contained in cellulosic biomass to C5 or C6 saccharides by subjecting a slurry of cellulosic biomass to a hot water treatment in a supercritical state or subcritical state; a washing step of successively washing a solid in the slurry with washing water after the saccharifying step, by using multiple stages of thickeners for washing arranged in series so that the direction of movement of the solid in the slurry and the direction of movement of overflow water are opposite to each other; and a concentration step of removing a solid residue from the washing water recovered in the washing step by using a thickener for still standing that is different from the thickeners for washing, and then concentrating a supernatant of the thickener for still standing by using a concentration device to give a saccharified solution. | 2015-11-19 |
20150329927 | Sugar Separation and Purification Through Filtration - Methods are disclosed that separate xylose from glucose in pretreated and enzyme-hydrolyzed cellulosic and/or lignocellulosic biomass. Filtration, especially diafiltration is used to reduce fermentation-impeding substances and xylose from glucose and growth-promoting factors. | 2015-11-19 |
20150329928 | A METHOD AND APPARATUS FOR SUPPLYING BLAST TO A BLAST FURNANCE - Apparatus for supplying blast to a blast furnace ( | 2015-11-19 |
20150329929 | An Efficient Process in the Production of Iron and Steel from Iron Ore - The invention discloses a method of reducing iron oxide to recover iron from iron content mixture. The method includes the step of mixing a reductant containing at least one of a silicon carbide or ferro-silicon with iron content mixture and heating it at a temperature ranging from 600-1000° C. for reaction to undergo. The iron content mixture is one of an iron ore, iron oxide and gangue material. The addition of reductant during the manufacture of sponge iron, DRI or pig iron or during reduction of iron ore assures advantages such as better converts yield, efficient use of resources, thus resulting in increasing productivity and reducing the cost of manufacturing. The method converts and upgrades low grade iron ore to high grade iron ore by dry beneficiation magnetic separation. The method also helps in recovery of iron from slag generated during iron and steel production. | 2015-11-19 |
20150329930 | REFORMER-GAS-BASED REDUCTION PROCESS WITH DECARBONIZATION OF THE FUEL GAS FOR THE REFORMER - In a process and apparatus for the reduction of metal oxides to form metalized material by contact with hot reducing gas, which is produced at least partially by catalytic reformation of a mixture of a gas containing carbon dioxide (CO | 2015-11-19 |
20150329931 | METHOD FOR STORING DISCONTINUOUSLY PRODUCED ENERGY - A method for temporarily storing energy in which iron ore is reduced with hydrogen and the resulting intermediate product of reduced iron ore and possibly accompanying substances is subjected to further metallurgical processing; the hydrogen is produced through electrolysis of water; the electrical energy required for the electrolysis is regenerative energy from hydroelectric and/or wind and/or photovoltaic sources or other regenerative forms of energy and the hydrogen and/or the intermediate product is produced regardless of the current demand, whenever enough regeneratively produced electrical energy is available; and unneeded intermediate product is stored until there is demand or it is used so that the regenerative energy that is stored therein is also stored and a method for storing discontinuously produced energy in which the discontinuously produced energy, when it is present or after its production, is conveyed into a process in which a storable intermediate product is produced from a source material and the storable intermediate product is stored until it is required and retrieved for the production of an end product. | 2015-11-19 |
20150329932 | HOT-ROLLED STEEL SHEET EXHIBITING EXCELLENT COLD FORMABILITY AND EXCELLENT SURFACE HARDNESS AFTER FORMING - Disclosed is a hot-rolled steel sheet that has a thickness of 3 to 20 mm and includes, in a chemical composition in mass percent, C of 0.3% or less (excluding 0%), Si of 0.5% or less (excluding 0%), Mn of 0.2% to 1%, P of 0.05% or less (excluding 0%), S of 0.05% or less (excluding 0%), Al of 0.01% to 0.1%, and N of 0.008% to 0.025%, with the remainder consisting of iron and inevitable impurities. A solute nitrogen content is 0.007% or more, and the carbon and nitrogen contents meet a condition as specified by 10C+N≦3.0. The microstructure of the steel sheet includes pearlite of less than 20% in area percentage, with the remainder approximately consisting of ferrite. The average grain size of the ferrite is 3 to 35 μm. The steel sheet has good cold formability during forming and still has predetermined surface hardness after forming. | 2015-11-19 |
20150329933 | TOP-ENTRY FLASH VESSEL ARRANGEMENT - The present invention relates to a method and an arrangement for pressure and temperature let down of autoclave discharge slurry ( | 2015-11-19 |