47th week of 2012 patent applcation highlights part 47 |
Patent application number | Title | Published |
20120295779 | Piri-Stretcher - A system for stretching the piriformis muscle may comprise a thigh strap, calf strap and handle assembly. One or two handles may be presented. The system may be attached to the thigh and calf of a first leg. While the knee of the first leg is bent, the ankle of the second leg my rest upon the thigh strap attached to the first leg. A handle may be pulled to urge the piriformis muscle into a more elongated position. | 2012-11-22 |
20120295780 | Stretching Machine - A stretching machine includes a machine rack, a foot stool, a hand stool, and a lying board installed in a middle part of the machine rack. The foot stool and the hand stool are respectively installed at two ends of the machine rack. The main body of the machine rack is formed by a multisection longitudinal stretch sleeve, and a longitudinal stretch regulation mechanism is provided to retractably regulate the multisection longitudinal stretch sleeve in the longitudinal direction. By the rotation of a pull hand and the engagement of a strip gear and a round gear wheel in the longitudinal stretch regulation mechanism to extend the second sleeve relative to the first sleeve, the user on the lying board can be extended to attain the stretching of the cervical vertebra thereof. | 2012-11-22 |
20120295781 | MICROFLUIDIC DEVICE FOR WHOLE BLOOD SAMPLE PREPARATION - A CD-based device for separating plasma from whole blood includes a substrate, a sedimentation chamber disposed in the substrate, and a collection chamber disposed in the substrate and in fluidic communication with the sedimentation chamber through a siphon channel. The sedimentation chamber includes a plurality of finger-like structures disposed along a radially outward edge of the sedimentation chamber, and protruding radially inward relative to the axis of rotation of the substrate. A method for separating plasma from whole blood using the CD-based device includes introducing a blood sample into the sedimentation chamber, rotating the substrate about an axis of rotation at a first rotational speed to separate the plasma from blood cells, and rotating the substrate about the axis of rotation at a second rotational speed, which is lower than the first rotational speed, to move the plasma from the sedimentation chamber into the collection chamber. | 2012-11-22 |
20120295782 | HERMETIC CENTRIFUGAL SEPARATOR - A hermetic centrifugal separator for centrifuging components, contained in a liquid mixture and having different density, comprises a rotating centrifuge rotor, which is arranged to rotate around a centre axis and comprises a casing which defines an inner separation space, a set of separation discs which are provided in the inner separation space of the centrifuge rotor, at least two channels, which connect to the separation space and comprise at least one inlet channel for supply of the liquid mixture of components to be separated to the separation space and at least one outlet channel for discharge of a component separated during operation from the separation space, a torque transmitting part around the centre axis and fixedly connected to the centrifuge rotor adapted to be driven in such a way that the centrifuge rotor is brought to rotate, outlet sealing means arranged to seal between the outlet channel and the rotating centrifuge rotor preventing entrainment of unwanted substances. To come to terms with the pressure drop in the separator, and especially in the area of the outlet sealing the invention is characterized in that between the separation space and said outlet sealing means is a pumping means arranged to provide pressure to feed the separated liquid through said outlet channel. | 2012-11-22 |
20120295783 | SHAPED METAL-CONTAINING COMPONENTS AND REACTION BASED METHODS FOR MANUFACTURING THE SAME - Methods of converting shaped templates into shaped metal-containing components, allowing for the production of freestanding, porous metal-containing replicas whose shapes and microstructures are derived from a shaped template, and partially or fully converting the shaped templates to produce metal-containing coatings on an underlying shaped template are described herein. Such coatings and replicas can be applied in a variety of fields including, but not limited to, catalysis, energy storage and conversion, and various structural or refractory materials and structural or refractory composite materials. | 2012-11-22 |
20120295784 | Ceramic Article - A ceramic article comprises ceramic fibers having an aspect ratio of greater than 3:1 and ceramic particles. The ceramic fibers are substantially randomly oriented in three dimensions in the ceramic article. A method of forming the ceramic article includes the step of providing a composition including ceramic fibers having an aspect ratio of greater than 3:1 and ceramic particles. The composition is extruded through a multi-screw extruder having at least three intermeshing screws to form an extrudate. The extrudate is heated to form the ceramic article. | 2012-11-22 |
20120295785 | REFRACTORY PRODUCT HAVING HIGH ZIRCONIA CONTENT - A fused and cast refractory product containing, in weight percentages on the basis of the oxides and for a total of 100%: | 2012-11-22 |
20120295786 | OIL AND POLAR ADDITIVE IMPREGNATED COMPOSITION USEFUL IN THE CATALYTIC HYDROPROCESSING OF HYDROCARBONS, A METHOD OF MAKING SUCH CATALYST, AND A PROCESS OF USING SUCH CATALYST - A composition that comprises a support material having incorporated therein a metal component and impregnated with both hydrocarbon oil and a polar additive. The composition that is impregnated with both hydrocarbon oil and polar additive is useful in the hydrotreating of hydrocarbon feedstocks, and it is especially useful in applications involving delayed feed introduction whereby the composition is first treated with hot hydrogen, and, optionally, with a sulfur compound, prior to contacting it with a hydrocarbon feedstock under hydrodesulfurization process conditions. | 2012-11-22 |
20120295787 | EXHAUST GAS PURIFYING CATALYST - An exhaust gas purifying catalyst includes a catalyst powder that includes a ceria-zirconia composite oxide on which platinum (Pt) is supported, and a Ce/alumina powder that includes alumina which contains cerium (Ce) in the structure thereof. The Ce/alumina undergoes only a slight decrease in specific surface area even in a lean atmosphere at a high temperature. The Pt supported on the ceria-zirconia composite oxide forms a Pt—O—Ce bond with the Ce present on surfaces of Ce/alumina so that migration of Pt is restrained and sintering of Pt is prevented. | 2012-11-22 |
20120295788 | COMPOSITION AND METHOD FOR STRESS MITIGATION IN PLANTS - A composition and method to mitigate plant autophagy and/or apoptosis of newly developing cells in plants grown under environmentally stressful growing conditions, such as high temperature. Exogenous application of a cytokinin, preferably kinetin, to either the roots or the foliage (i.e., flowers and leaves) of plants has been discovered to overcome, or at least substantially mitigate, autophagy when applied during or just prior to flowering. Experimental results indicate that high temperature-induced autophagy, and subsequent new cell apoptosis, is the result of a deficiency of cytokinin in the plant tissues. The application of low concentrations of potassium together with the cytokinin appears to provide a synergistic effect by amplifying the effect of the cytokinin to lessen autophagy and increase crop productivity. | 2012-11-22 |
20120295789 | PLANT GROWTH REGULATION - The present invention relates to a method for improving the plant growth regulation of and/or enhancing dicotyle-donous crop plants, by applying to the plants trinexapac-ethyl and prohexadione-calcium, and to use of a composition comprising the same. | 2012-11-22 |
20120295790 | Sustained Release Silica Microcapsules - The present invention relates to a microcapsule exhibiting desirable sustained-release properties, which microcapsule comprises a core material comprising an active ingredient encapsulated within a silica shell, characterized in that the outer surface of such silica shell has a layer of a metal selected from Group 2a, Group 8, Group 2b or Group 3a of the Periodic Table bound thereto. In other aspects this invention relates to a method of making such a microcapsule; a pesticidal composition comprising microcapsules comprising a pesticidal active ingredient and a suitable carrier; and to a method of controlling pests comprising applying an effective amount of such a pesticidal composition to a locus where pests are or are expected to be present. | 2012-11-22 |
20120295791 | METHOD FOR REDUCING TEMPERATURE STRESS OF PLANTS - The present invention provides: a method for reducing temperature stress of plants which comprises applying an effective amount of one or more compounds selected from the group consisting of a compound represented by the formula (I) and an agriculturally acceptable salt thereof to a plant that has been exposed to or to be exposed to a temperature stress factor; and so on. | 2012-11-22 |
20120295792 | ARRANGEMENT FOR ELECTRICALLY CONDUCTIVELY CONNECTING TWO ELECTRICAL UNITS - An arrangement for electrically conductively connecting two electrical units by means of a bipolar high voltage direct current transmission, in which between the units are arranged at least two electrical direct current cables constructed as superconductive cables. The superconductive cables are mounted separately from each other in a cryostat ( | 2012-11-22 |
20120295793 | METHODS OF GENERATING MODIFIED POLYNUCLEOTIDE LIBRARIES AND METHODS OF USING THE SAME FOR DIRECTED PROTEIN EVOLUTION - The invention provides for methods of generating modified polynucleotide libraries by inserting and/or deleting at least three nucleotide residues in polynucleotide sequences. Theses methods may be used with other methods of gene modification such as gene shuffling. The invention further provides methods of directed molecular evolution using the modified polynucleotide libraries produced by these methods. | 2012-11-22 |
20120295794 | COMPOSITIONS, METHODS, AND KITS FOR DETECTING RIBONUCLEIC ACID - Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a polypeptide comprising double-strand specific RNA ligase activity, without an intervening purification step. The ligated product is reverse transcribed, then at least some of the ribonucleosides in the reverse transcription product are removed. Primers are added and amplified products are generated. In certain embodiments, the sequence of at least part of at least one species of amplified product is determined and at least part of the corresponding RNA molecule is determined. In some embodiments, at least some of the amplified product species are detected, directly or indirectly, allowing the presence and/or quantity of the RNA molecule of interest to be determined. | 2012-11-22 |
20120295795 | METHODS FOR OPERATING CHEMICALLY-SENSITIVE SAMPLE AND HOLD SENSORS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-11-22 |
20120295796 | System and Method of Predicting Chemical Interaction and Functionality of Molecules - A system and method of identifying a target molecule that bind to the bioactive site of a protein or protein complex is described. The system and method includes the steps of calculating the information signature of a first molecule that is known to bind to the bioactive site of a protein or protein complex, wherein the information signature is a string of numerical values based on the average distance and physico-chemical properties of each atom of a plurality of atoms in the first molecule, calculating the information signature of each target molecule in a library of target molecules, comparing the information signature of the first molecule to the information signatures of the target molecules, and selecting the target molecules having an information signature that is similar to the information signature of the first molecule. | 2012-11-22 |
20120295797 | METHODS FOR DIAGNOSIS AND PROGNOSIS OF PULMONARY HYPERTENSION - The invention relates to diagnostic and prognostic assays and kits for pulmonary hypertension (PH) and types thereof. The invention includes detecting the expression level of markers associated with pulmonary hypertension for diagnosis, progosis, or treatment of pulmonary hypertension. | 2012-11-22 |
20120295798 | SORTING OF ADHERENT CELLS BY SELECTIVE TRANSFORMATION OF LABELS - Adherent cells bearing characteristics that are detectable only in the adherent state can be sorted on the basis of these characteristics independently of their adherent state, by applying a transformable label to the entire population of cells, both those bearing the characteristics of interest and those not, in their adherent state and identifying the locations of the cells of interest on the adherent surface. The cells of interest, or all cells other than those of interest, are then selectively treated to transform the labels and achieve differentiation between the cells of interest and the remaining cells. All cells are then released from the adherent state and sorted in the same manner as non-adherent cells but on the basis of whether the labels are transformed or not transformed. | 2012-11-22 |
20120295799 | Methods and compositions for detecting autoimmune disorders - The invention provides methods and compositions useful for detecting autoimmune disorders. | 2012-11-22 |
20120295800 | OLIGONUCLEOTIDES FOR CANCER DIAGNOSIS - The present invention provides sets of oligonucleotides corresponding to genes encoding proteins involved in protein synthesis and/or stability or genes encoding proteins involved in the regulation of defense and/or chromatin remodeling for use in preparing transcript patterns particularly for cancer diagnosis. The invention also extends to such sets and kits containing such sets as well as related method reliant on analysis of marker polypeptides encoded by the genes to develop characteristic expression profiles. | 2012-11-22 |
20120295801 | High-Throughput In Situ Hybridization - Novel methods and compositions for providing high-throughput fluorescence in situ hybridization (FISH) are provided. | 2012-11-22 |
20120295802 | METHODS AND COMPOSITIONS FOR CANCER TREATMENT RELATING TO BRCA1 BRCT DOMAIN RECOGNITION OF PHOSPHORYLATED BACH1 - The present invention relates to compounds (e.g., peptidomimetics and non-peptides) that treat, prevent, or stabilize cellular proliferative disorders and methods of treating, preventing, or stabilizing such disorders. The invention also provides three-dimensional structures of a human BRCT domain-BACH1 phosphopeptide complex. | 2012-11-22 |
20120295803 | LUNG CANCER SIGNATURE - The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to cancer markers as diagnostic markers and clinical targets for lung cancer. | 2012-11-22 |
20120295804 | Compositions and Methods for Diagnosis and Treatment of Breast Cancer - The present invention is a population of breast cancer cells with preference for establishing dormancy in bone marrow. The breast cancer cells have characteristics of stem cells and express high levels of Oct4, designated Oct4 | 2012-11-22 |
20120295805 | SOLID PHASE METHODS FOR THERMODYNAMIC AND KINETIC QUANTIFICATION OF INTERACTIONS BETWEEN NUCLEIC ACIDS AND SMALL MOLECULES - Methods for analysis of interactions between nucleic acid-binding agents (BAs) and nucleic acids (NAs) by performance of nucleic acid denaturation assays on solid supports. Typically, BA is a small molecule less than 1000 g/gmol in molecular weight. The methods provide quantitative thermodynamic and kinetic analysis of BA-NA interaction; for example, in the form of free energies, enthalpies, and entropies of BA-NA binding in case of thermodynamic analysis, or in the form of rate constants and activation energies of BA-NA binding in the case of kinetic analysis. Examples of BAs of interest include transcription regulators and other NA-recognition molecules such as dyes and drug potentiators, DNA-targeted therapeutic agents including anticancer, antibiotic, antiviral, and antitrypanosomal compounds, carcinogens, and any other molecules whose interaction with DNA may, or is suspected to, lead to a biologically-relevant consequence. BA may bind to NA either through physical interactions or through formation of covalent adducts. | 2012-11-22 |
20120295806 | METHODS, SYSTEMS, AND COMPOSITIONS FOR DETECTION OF MICROBIAL DNA BY PCR - This invention provides methods, systems, and compositions for detecting low abundance microbial DNA in a sample by broad-range PCR. Methods of the present invention are based on a novel strategy that tags the 5′-end of the target DNA templates with a non-bacterial tagging sequence so as to set the templates apart from the endogenous contaminants present in the PCR reagents. There is also provided fusion probes for tagging the templates and primer sets to amplify the tagged templates. Systems and kits for facilitating and automating methods of the present invention are also provided. | 2012-11-22 |
20120295807 | CHROMOSOME COPY NUMBER GAIN AS A BIOMARKER OF UROTHELIAL CARCINOMA LETHALITY - Diagnostic assays for medically classifying cancer patients are provided. The method comprises assessing a tissue sample of the patient for the presence of a copy number gain of chromosome regions 1q23.3 and/or 1q21.2. Copy number gain of chromosome regions 1q23.3 and/or 1q21.2 is indicative of a less favorable prognosis as compared to the prognosis if there was no copy number gain in the same regions. | 2012-11-22 |
20120295808 | Solid Support Assay Systems and Methods Utilizing Non-Standard Bases - Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target oligonucleotide. In other instances, incorporation of a non-standard base (e.g., via PCR or ligation) is used in the assay. | 2012-11-22 |
20120295809 | RECURRENT GENE FUSIONS IN PROSTATE CANCER - Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided. | 2012-11-22 |
20120295810 | Non-Invasive Diagnosis of Graft Rejection in Organ Transplant Patients - The disclosure provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. The methods comprise determining the presence or absence of one or more nucleic acids from a donor transplant, wherein said one or more nucleic acids from said donor are identified based on a predetermined marker profile, and diagnosing or predicting transplant status or outcome based on the presence or absence of said one or more nucleic acids. | 2012-11-22 |
20120295811 | APTAMERS DIRECTED AGAINST THE MATRIX PROTEIN-1 OF TYPE A INFLUENZA VIRUSES AND USES THEREOF - The present invention relates to nucleic acids that bind specifically to the matrix protein-1 of type A influenza viruses and uses thereof for detecting such viruses in a sample of interest. More particularly, the present invention relates to a nucleic acid that binds specifically to matrix protein-1 of type A influenza viruses characterized in that said nucleic acid comprises the following nucleotide sequence: 5′-N1-NS1-U-N3-A-NS3-NS5-NS7-NS6-CGCAU-NS4-C-N4-NS2-N2-3′ wherein: -N1 consists of a nucleotide -NS1 and NS2 consist of polynucleotides having 3 or 4 nucleotides in length, and NS1 and NS2 have complementary sequences; -N3 and N4 consists of a nucleotide, and N4 is complementary to N3; -NS3 and NS4 consist of polynucleotides having 3 nucleotides in length, and -NS3 and NS4 have complementary sequences -NS5 and NS6 consist of polynucleotides having 3 nucleotides in length, and -NS5 and NS6 have complementary sequences; -NS7 consists of a polynucleotide selected from the group consisting of AGAAUC (SEQ ID NO:12), UGAG (SEQ ID NO: 13), UAUUCC (SEQ ID NO:14), AGAU (SEQ ID NO:15), AGAATC (SEQ ID NO:16) or TGAG (SEQ ID NO:17) -N2 consists of a nucleotide that is complementary or not complementary to nucleotide N1. | 2012-11-22 |
20120295812 | METHOD FOR EXTRACTING STAPHYLOCOCCUS AUREUS ANTIGEN, REAGENT FOR EXTRACTING STAPHYLOCOCCUS AUREUS ANTIGEN, AND METHOD FOR ASSESSING STAPHYLOCCOCCUS AUREUS - The invention provides a method for extracting a | 2012-11-22 |
20120295813 | PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES - The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one-on average—to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA. | 2012-11-22 |
20120295814 | CA-125 Immune Complexes as Biomarkers of Ovarian Cancer - The invention is directed to assays of CA-125 immune complexes that can be used diagnostically. It also includes glass or plastic plates or slides on which the monoclonal antibodies against CA-125 have been immobilized and kits containing these plates or slides. | 2012-11-22 |
20120295815 | DIAGNOSTIC GENE EXPRESSION PLATFORM - The invention provides a set of oligonucleotide probes specific to cancer, preferably breast cancer, kits containing them and their use in preparing standard and test patterns and methods of diagnosis of cancer, preferably breast cancer. | 2012-11-22 |
20120295816 | SINGLE TUBE MULTIPLEX ASSAY FOR DETECTION AND QUANTIFICATION OF ADULTERANTS IN BASMATI RICE SAMPLES - The present invention provides a single tube multiplex assay for distinguishing basmati from non-basmati rice varieties, and thereby identifying the adulteration of basmati rice varieties. The present invention further provides a method for quantifying adulteration in basmati rice varieties. The present invention also provides a kit for performing a multiplex assay for distinguishing basmati from non-basmati rice varieties. The kit may comprise a primer directed to an SSR loci, appropriate reagents for PCR, and optionally, a package insert for conducting the assay. | 2012-11-22 |
20120295817 | Aza-benzazolium Containing Cyanine Dyes - Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms. | 2012-11-22 |
20120295818 | METHOD OF MULTI PATHOGEN DETECTION - A culturing method includes culturing a sample having one or more species of target pathogens of a detection assay and competing microorganisms under oxygen-poor condition in a growth medium. The growth medium can be a non-selective medium. The oxygen-poor condition is effective to prevent competing microorganisms from suppressing growth of the target pathogens. This method can be used in combination with a sample preparation method for large volume particulate samples using highly porous filter material and porous spherical filter aid. | 2012-11-22 |
20120295819 | METHODS AND COMPOSITIONS FOR MULTIPLEX PCR - The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids present in a sample. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences. In one aspect, the invention relates to target-specific primers useful for the selective amplification of one or more target sequences associated with cancer or inherited disease. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to detect the presence of genetic variants. | 2012-11-22 |
20120295820 | MANAGEMENT OF CORROSION IN PHOSPHATE BRINES - Phosphate brines are disclosed having reduced corrosive ratings. The phosphate brines include an additive system that reduces the corrosiveness of the phosphate brines compared to the phosphate brines in the absence of the additive system. | 2012-11-22 |
20120295821 | High Performance Drilling Fluids with Submicron-Size Particles as the Weighting Agent - Drilling fluids comprising a carrier fluid; a weighting agent that comprises sub-micron precipitated barite; a particle having a specific gravity of greater than about 2.6; and, a bridging agent that is not the submicron-precipitated barite or the particle. The weighting agent has a particle size distribution such that at least 10% of particles in the sub-micron precipitated barite have a diameter below about 0.2 microns, at least 50% of the particles in the sub-micron precipitated barite have a diameter below about 0.3 microns and at least 90% of the particles in the sub-micron precipitated barite have a diameter below about 0.5 microns. The particle has a specific gravity of greater than about 2.6 is not sub-micron precipitated barite. The ratio of the sub-micron precipitated barite to the particle is about 10:90 to about 99:1. The bridging agent comprises a degradable material. | 2012-11-22 |
20120295822 | System and Process for Production of Polyethylene and Polypropylene - A method for introducing inhibitor into a fluid to be treated, the method including forming a dispersion comprising droplets, particles, or gas bubbles of inhibitor dispersed in a continuous phase of a carrier, wherein forming the dispersion comprises subjecting a mixture of the inhibitor and the carrier to a shear rate of greater than about 20,000 s | 2012-11-22 |
20120295823 | OIL RELEASE WITH N-LAUROYL AMINO ACID-BASED COMPOUNDS - Chemical compounds that are N-lauroyl amino acids or derivatives thereof were found to have oil-releasing activity. Solutions containing these compounds may be introduced into oil reservoirs or onto oil-contaminated surface sites to release oil from oil-coated surfaces. The released oil may be recovered for further processing or waste disposal. | 2012-11-22 |
20120295824 | HYDROPHILIC SURFACES FOR REDUCING FRICTION FORCES - A substrate (for example an implantable medical device) is provided with a lubricious surface by grafting onto the surface monomers containing acrylamide groups and then hydrolysing said groups under alkaline conditions, the grafting step being carried out in an aqueous environment. | 2012-11-22 |
20120295825 | ABRADABLE COMPOSITION AND METHOD OF MANUFACTURE - A thermal spray powder having a first component A mechanically blended with a second component B, wherein the first component A is a metal or metal composite, preferably at least one of Ni—Cr—Al clad ABN, Ni—Cr—Al clad HBN, Ni—Cr—Al clad agglomerated hexagonal boron nitride powder with organic binder, Ni—Cr—Al agglomerated hexagonal boron nitride powder with inorganic binder, an MCrAlY type powder where M is at least one of Ni, Co, Fe, and wherein component B is a polymer clad with at least one of nickel, nickel alloys, nickel chrome alloys, nickel chrome aluminum alloys, nickel aluminum alloys, cobalt and cobalt alloys. The result is a thermal spray powder of four distinctly different phases making the powder a four-phase blend. | 2012-11-22 |
20120295826 | Method of Lubricating an Internal Combustion Engine - The present invention relates to a method of lubricating an internal combustion engine with a power output of at least 1600 kilowatts by supplying to the internal combustion engine a lubricating composition containing an oil of lubricating viscosity and at least 0.5 wt % of a hydrocarbyl-substituted carboxylic acid or anhydride thereof. The invention further provides a lubricating composition suitable for the method. | 2012-11-22 |
20120295827 | Lubricant With Enhanced Energy Efficiency - Lubricant compositions useful especially for the lubrification of gears, having a boundary loss coefficient X | 2012-11-22 |
20120295828 | Composition for Removing Photoresist and/or Etching Residue From a Substrate and Use Thereof - Compositions containing certain organic solvents comprising at least 50% by weight of a glycol ether and a quaternary ammonium compound are capable of removing residues such as photoresist and/or etching residue from an article. | 2012-11-22 |
20120295829 | NON-CORROSIVE OVEN DEGREASER CONCENTRATE - The invention relates to a non-corrosive degreasing concentrate and ready to use formulation. In particular, non-corrosive compositions capable of removing polymerized grease as effectively as some alkali metal hydroxide (i.e. caustic) based degreasers without requiring the use of personal protective equipment are disclosed. | 2012-11-22 |
20120295830 | DETERGENT COMPOSITIONS WITH COMBINATIONS OF ACRYLIC AND MALEIC ACID HOMOPOLYMERS AND/OR SALTS THEREOF FOR ALUMINUM PROTECTION - A warewashing detergent composition is provided for use for in cleaning of alkaline sensitive metals such as aluminum or aluminum containing alloys. The compositions include alternatives to sodium tripolyphosphate and/or other phosphorous containing raw materials, while retaining cleaning performance and corrosion prevention. According to the invention, a synergistic combination of polyacrylic and polymaleic polymers is used as corrosion inhibitors in traditional alkaline detergent compositions. | 2012-11-22 |
20120295831 | FOAMING LIGHT DUTY LIQUID DETERGENT COMPOSITIONS, METHODS OF MAKING AND USES THEREOF - Foaming light duty liquid detergent formulations that contain at least one cleaning solvent, at least one anionic surfactant and at least foam stabilizing surfactant are disclosed. The compositions of the presently described technology are useful for soil removal applications including, but not limited to, washing dishes by hand and cleaning bathroom and kitchen articles and/or surfaces. | 2012-11-22 |
20120295832 | Novel Lipids and Compositions for Intracellular Delivery of Biologically Active Compounds - The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery. | 2012-11-22 |
20120295833 | Polysaccharides having an adjustable degree of functionalization - An anionic polysaccharide comprising carboxylic acid functional groups of formula I: | 2012-11-22 |
20120295835 | SGEF CONTROLS MACULAR, CORPUS CALLOSUM AND HIPPOCAMPAL FUNCTION AND DEVELOPMENT, LIVER HOMEOSTASIS, FUNCTIONS OF THE IMMUNE SYSTEM, FEVER RESPONSE ATHEROSCLEROSIS AND TUMOROGENIC CELL GROWTH - The invention provides a composition comprising SGEF protein or gene as a therapeutic means to clinical or subclinical defects associated with anomalies of at least one from among the macula, corpus callosum, hippocampus, liver or immune system or feverless response to infection. Methods of diagnosis of such disease and development anomalies are based on detection of mutations of the SGEF gene. The SGEF protein is also used as a preventive or curative treatment of atherosclerosis by local or systemic delivery. The invention also provides a composition comprising an inhibitor of the SGEF gene expression or SGEF protein concentration, as a therapeutic means for glaucoma, osteoarthritis, auto-inflammatory diseases, tumors or cancers. | 2012-11-22 |
20120295836 | GLP-I Agonist And Cardiovascular Complications - Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist. | 2012-11-22 |
20120295837 | NOVEL ANTIMICROBIAL AGENTS - A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking therebetween, such as an omega-amino-fatty acid residue, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same. | 2012-11-22 |
20120295838 | Selective poly-substituted glycine antibiotics and related compositions - Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively. | 2012-11-22 |
20120295839 | METHOD OF TREATMENT AND PROPHYLAXIS OF BACTERIAL VAGINOSIS - Methods of treatment or prophylaxis of bacterial vaginosis, prevention of recurrence of bacterial vaginosis and alleviation or prevention of symptoms or diagnostic criteria of bacterial vaginosis are provided. The methods include administration of an effective amount of a macromolecule comprising a polylysine, polyamidoamine, poly(etherhydroxyamine) or poly(propyleneimine) dendrimer and one or more sulfonic acid containing moieties attached thereto. | 2012-11-22 |
20120295840 | TREATMENT OF ASPERGILLUS INFECTIONS WITH ALPHA THYMOSIN PEPTIDES - A method for treating a human infected with | 2012-11-22 |
20120295841 | Sanglifehrin Based Compounds - There are provided inter alia compounds of formula (I) | 2012-11-22 |
20120295842 | PHENANTHRIDINE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS - The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient. | 2012-11-22 |
20120295843 | COMBINATION THERAPY FOR THE TREATMENT OF HCV INFECTION - The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention. | 2012-11-22 |
20120295844 | USE OF APROTININ FOR TREATING PARASITIC INFECTIONS AND PROGNOSING BOVINE TRYPANOTOLERANCE - The present invention relates the use of aprotinin in the treatment of parasitic diseases or infections that affect domesticated mammals, in particular the cattle, especially bovines. In particular, aprotinin finds application in the fight against pathogenic effects induced by parasites in the Trypanosomatidae family, such as the protozoa that belong to the | 2012-11-22 |
20120295845 | IMIDAZO-PYRAZOLES AS GPR119 INHIBITORS - Compounds of formula (I) wherein: X is (A) or (B); Y is O or a bond; R | 2012-11-22 |
20120295846 | PHARMACEUTICAL COMPOSITION COMPRISING A GLP-1 AGONIST, AN INSULIN AND METHIONINE - A liquid composition comprising a GLP-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate. | 2012-11-22 |
20120295847 | Acylated GLP-1 Compounds - Protracted GLP-1 compounds and therapeutic uses thereof. | 2012-11-22 |
20120295848 | SUSTAINED-RELEASE COMPOSITION AND PROCESS FOR PRODUCING THE SAME - Present invention is to provide a sustained-release composition which contains a physiologically active substance in high content even when gelatin is not included, and suppresses its initial excessive release and, thus, can achieve a stable release rate over about one month. A sustained-release composition containing a lactic acid-glycolic acid polymer having a ratio or weight average molecular weight and number average molecular weight of about 1.90 or lower, or a salt thereof, and a physiologically active substance. | 2012-11-22 |
20120295849 | USE OF GLP-1 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS - The present invention describes the methods of using incretin mimetics such as GLP-1 receptor agonists, particularly exenatide, to treat short bowel syndrome and spastic or hyperactive esophageal motor disorders. | 2012-11-22 |
20120295850 | GLP-1 RECEPTOR AGONISTS TO TREAT PANCREATITIS - The disclosure provides the use of GLP-1 receptor agonist compounds to treat pancreatitis (e.g., acute, chronic, hemorrhagic, necrotizing) in patients. The disclosure also provides the use of GLP-1 receptor agonist compounds to reduce elevated plasma amylase and/or lipase concentrations in patients. An exemplary GLP-1 receptor agonist compound is exenatide. | 2012-11-22 |
20120295851 | PEPTIDES, COMPOSITIONS AND USES THEREOF - Described is an N-terminal hexapeptide fragment of maximakinin, QUB 698.8, which exhibits potent tissue selective actions on smooth muscle. It demonstrates a high degree of selectivity for arterial smooth muscle over small intestinal smooth muscle, causing potent relaxation of arterial smooth muscle, while causing less potent contraction of ileal smooth muscle. It may be used treatment of diseases of the cardiovascular system and in promotion of angiogenesis. | 2012-11-22 |
20120295852 | METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES - The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist. | 2012-11-22 |
20120295853 | NEURONAL PAIN PATHWAY - The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G (“PKG”), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk. | 2012-11-22 |
20120295854 | Methods of Inducing Tissue Regeneration - Methods are provided for producing cells within a lineage (lineage restricted cells) from post-mitotic differentiated cells of the same lineage ex vivo and in vivo, and for treating a subject in need of tissue regeneration therapy by employing these lineage-restricted cells. In addition, the production of lineage restricted cells from postmitotic tissues derived from patients with diseases allows for a characterization of pathways that have gone awry in these diseases and for screening of drugs that will ameliorate or correct the defects as a means of novel drug discovery. Also provided are kits for performing these methods. | 2012-11-22 |
20120295855 | METHODS FOR REDUCING OXIDATIVE STRESS IN A CELL WITH A SULFHYDRYL PROTECTED GLUTATHIONE PRODRUG - The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug. | 2012-11-22 |
20120295856 | FREDERICAMYCIN DERIVATIVES - The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases. | 2012-11-22 |
20120295857 | EXTRACT OBTAINED BY A COMMERCIALLY VIABLE PROCESS FOR THE EXTRACTION OF FUROSTANOLIC SAPONINS FROM FENUGREEK SEEDS, IN WHICH ONE OF THE COMPOUNDS IN THE EXTRACT IS PROTODIOSCIN - Disclosed is an extract obtained by a commercially viable process for the extraction of furostanolic saponins from fenugreek seeds, in which one of the compounds in the extract is protodioscin. The process includes providing plurality of fenugreek seeds and crushing the same by milling and grinding; performing a primary extraction on the prepared fenugreek seeds using a first hydrophilic polar solvent which is a lower primary aliphatic alcohol followed by ion-exchange chromatography; performing a secondary extraction after ion-exchange chromatography using a composite solvent; and decolorizing the final extract by use of activated charcoal concentration of the extract by heating and vacuum drying sieving the final powdered product. | 2012-11-22 |
20120295858 | USE OF DANSHENSU, NOTOGINSENOSIDE R1 OR THEIR COMBINATION IN PREPARATION OF MEDICAMENTS FOR PREVENTING AND TREATING DISEASES CAUSED BY MICROCIRCULATION DISORDER - The present invention relates to a new use of traditional Chinese drug products of Danshensu (DLA), Notoginsenoside R1 (R1) and their combination, in particular to the therapeutic and preventive effects of DLA, R1 and their combination on the diseases caused by microcirculation disorder. | 2012-11-22 |
20120295859 | METHOD FOR TREATMENT OF MALARIA - A method for treatment of malaria including administering to a patient in need thereof a flavonoid glycoside compound. | 2012-11-22 |
20120295860 | ORGANIC COMPOUNDS - The present invention relates to a compound The instant invention relates to a compound of formulae (I A), (I B), (X A), (X B), (Y A) or (Y B), | 2012-11-22 |
20120295861 | Combination Therapy With Organic Arsenicals - The invention provides a combination therapy wherein one or more other therapeutic agents are administered with an organic arsenical, preferably SGLU-I or a pharmaceutically acceptable salt thereof. The invention also relates to methods for the treatment of cancer, comprising administering SGLU-I in combination with another therapeutic agent. Another aspect of the invention relates to a kit comprising SGLU-I and another therapeutic agent. | 2012-11-22 |
20120295862 | NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING OF NUCLEIC ACIDS - Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids. | 2012-11-22 |
20120295863 | Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases - The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A | 2012-11-22 |
20120295864 | METHOD FOR TREATING ACUTE MYELOID LEUKEMIA - The present invention relates to the use of BI 6727 or a salt thereof or the hydrate thereof for treating patients suffering from acute myeloid leukemia (AML) comprising the administration of a high dose of BI 6727 according to a specific dosage schedule, optionally in combination with cytarabine. | 2012-11-22 |
20120295865 | SHARK-LIKE CHONDROITIN SULPHATE AND PROCESS FOR THE PREPARATION THEREOF - The present invention provides a shark-like chondroitin sulphate and a process for the preparation thereof. In particular, the present invention relates to a shark-like chondroitin sulphate, having a very low amount of 4-sulphate, a high charge density and a biological activity comparable to natural chondroitin sulphates. The invention also relates to a process for the preparation of said shark-like chondroitin sulphate affording substantially higher productivities and better reproducibility of product quality. The shark-like chondroitin sulphate of the invention shows a high molecular mass and its in vitro biological and anti-inflammatory effectiveness has been shown to be comparable to that of natural products making this polysaccharide potentially useful as a drug in pharmaceutical preparations and nutraceuticals. | 2012-11-22 |
20120295866 | Synthesis And Use Of Glycoside Pro-Drug Analogs - The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs. This invention relates to a method for the production of a broad group of glycosylated drugs, including but not limited to propofol, acetaminophen, and camptothecin carbohydrate derivatives. | 2012-11-22 |
20120295867 | METHOD AND PHARMACEUTICAL TO TREAT SPINAL DISCS - Methods for reducing chronic pain caused by a disrupted spinal disc are described. In one method, a solution is injected into the disc. The solution includes chondroitin sulphate, glucosamine HCl, and dextrose. The solution may optionally include dimethyl sulfoxide and/or an anesthetic such as bupivicaine. | 2012-11-22 |
20120295868 | Medical Uses of Glucans - The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto. | 2012-11-22 |
20120295869 | Sterile Hyaluronic Acid Solutions - Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution. | 2012-11-22 |
20120295870 | CROSS-LINKING OF LOW-MOLECULAR WEIGHT AND HIH-MOLECULAR WEIGHT POLYSACCHARIDES, PREPARATION OF INJECTABLE MONPHASE HYDROGELS, POLYSACCHARIDES AND HYDROGELS OBTAINED - A process for the crosslinking of at least one polymer selected from polysaccharides and derivatives thereof, which is carried out in an aqueous solvent by the action of an effective and non-excessive amount of at least one crosslinking agent, characterized in that it is carried out on a mixture containing at least one low-molecular weight polymer and at least one high-molecular weight polymer. A process for the preparation of an injectable monophase hydrogel of at least one crosslinked polymer selected from polysaccharides and derivatives thereof. Crosslinked polymers and injectable monophase hydrogels respectively obtainable by each of said processes. | 2012-11-22 |
20120295871 | HEPARIN-BASED COMPOSITIONS AND METHODS FOR THE INHIBITION OF METASTASIS - The invention provides the use in combination of a heparin containing composition that has anticoagulant activity when used alone, such as an unfractionated heparin or low molecular weight heparin, in combination with an inhibitor of the anticoagulation activity/effect or effect of heparin, for the inhibition of metastasis. | 2012-11-22 |
20120295872 | Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases - The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma. | 2012-11-22 |
20120295873 | BRANCHED SOLUBLE GLUCOSE POLYMERS FOR PERITONEAL DIALYSIS - The invention relates to branched soluble glucose polymers made of starch having an amylose content of at least 30 wt %, preferably 35 wt % to 80 wt %, having a glycosidic linkage α-1,6 content of 7% to 10%, preferably 8% to 9%, and a MW of 50,000 to 150,000 daltons, characterized in that the polymers are resistant to pancreatic alpha amylase, expressed according to a test “B” for a reducing sugar content of 25% to 35%, and a MW of released products of 6,000 to 12,000 daltons. | 2012-11-22 |
20120295874 | COFERONS AND METHODS OF MAKING AND USING THEM - The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore. | 2012-11-22 |
20120295875 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS - This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent. | 2012-11-22 |
20120295876 | PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES - The present invention relates to novel pyridazine derivatives of formula (I) wherein R | 2012-11-22 |
20120295877 | Therapeutic Compounds - The present invention relates to compounds of Formula (I) and (Ia) | 2012-11-22 |
20120295878 | METHOD FOR THE TREATMENT OF CANCER - Provided is a method for determining the prognosis of cancer in a female patient with a solid tumor. The percentage of solid tumor cells expressing TUBB3 protein and the percentage of solid tumor cells expressing TUBB6 protein in a solid tumor sample from the patient is determined. Detection of TUBB6 protein expression in a percentage of solid tumor cells of the female patient that is less than the median percentage expression for TUBB6 protein and detection of TUBB3 protein expression in a percentage of solid tumor cells of the female patient that is less than the median percentage expression for TUBB3 protein indicates a patient with good prognosis; and wherein detection of TUBB6 protein expression in a percentage of solid tumor cells of the female patient that is equal to or greater than the median percentage expression for TUBB6 protein and/or detection of TUBB3 protein expression in a percentage of solid tumor cells of the female patient that is equal to or greater than the median percentage expression for TUBB3 protein indicates a patient with poor prognosis. Also provided is a method of sensitizing a cancer cell from a solid tumor from a male patient other than a prostate cancer cell to treatment with a chemotherapeutic agent comprising administering an effective amount of antiandrogen and a chemotherapeutic agent other than an antiandrogen. The antiandrogen may be administered before, after, or at the same time as the chemotherapeutic agent. | 2012-11-22 |
20120295879 | NK1 Antagonists - A compound having the general structure shown in Formula I: | 2012-11-22 |