48th week of 2015 patent applcation highlights part 35 |
Patent application number | Title | Published |
20150338325 | UNIVERSAL GRIP SYSTEM - Provided are universal grip systems and method of using universal grip systems to test coupons. According to various examples, a universal grip system includes two grips and two guide posts for supporting the two grips and allowing the two grips to move with respect to each other. Each grip may include one or two wedges. The wedges are used to engage the coupons during testing and provide anti-buckling support and/or anti-rotation support. The wedges are slidably coupled within corresponding grips, which allows the universal grip system to engage and disengage the coupons by moving one grip with respect to another. The grips may be constructed from thermally neutral materials, such as invar 36. The grips may thermally isolated from the guide posts by, for example, a set of spacers disposed between the grips and linear bearing slidably coupled to the guide posts. | 2015-11-26 |
20150338326 | WIRELESS SENSOR MODULE - A sensor module for monitoring bearings in steel industry applications, the sensor module comprising an embedded portion for being fitted into a hole in a bearing component of the bearing to be monitored, wherein the embedded portion comprises at least one sensor. The embedded portion includes a clamping mechanism generating a clamping force acting on at least two opposing lateral internal faces of the hole. | 2015-11-26 |
20150338327 | APPARATUS, SYSTEM AND METHODS FOR DETERMINING THE IMPACT ATTENUATION OF A SURFACE - The instant disclosure relates to an apparatus, system and methods for determining the impact attenuation or hardness of a surface for a playground or sports field in order to mitigate or reduce sports and playground related injuries. | 2015-11-26 |
20150338328 | SUBSTRATE CLEANING APPARATUS AND METHOD EXECUTED IN THE SAME - A substrate cleaning apparatus | 2015-11-26 |
20150338329 | BULK MODULUS MEASUREMENT AND FLUID DEGRADATION ANALYSIS - An apparatus and method to analyze fluid degradation in a closed system is disclosed. The method includes collection of a sample fluid from the closed system. The sample fluid collected is maintained at a sample fluid pressure, which is substantially equivalent to a pressure of the closed system. Thereafter, a change of a volume of the sample fluid is caused, which generates a change in the sample fluid pressure. A series of sample fluid pressures and volumes of the sample fluid are taken. Next, a bulk modulus of the sample fluid is determined. The bulk modulus of the sample fluid is compared with a baseline bulk modulus. Lastly, the method involves generation of a communication when the bulk modulus of the sample fluid breaches a tolerance. | 2015-11-26 |
20150338330 | Method for Comprehensive Assessment of Platelet Aggregation - A method for comprehensively and quantitatively analyzing platelet aggregability, and stability and persistence of platelet aggregates, which method comprises the steps of: reacting a platelet-activating reagent with blood in a closed container; injecting a liquid which is not mixable with blood into the container using a pump connected to a first end of the container, thereby pushing the mixture of the platelet-activating reagent and the blood out from the container and allowing the mixture to pass through a filter in a filter device connected to a second end of the container; and measuring the pressure exerted on the pump. | 2015-11-26 |
20150338331 | METHODS, SYSTEMS, AND COMPUTER PROGRAM PRODUCTS FOR MEASURING THE DENSITY OF MATERIAL INCLUDING A NON-NUCLEAR MOISTURE PROPERTY DETECTOR - The subject matter described herein includes methods, systems, and computer program products for measuring the density of a material. According to one aspect, a material property gauge includes a nuclear density gauge for measuring the density of a material. A radiation source adapted to emit radiation into a material and a radiation detector operable to produce a signal representing the detected radiation. A first material property calculation function may calculate a value associated with the density of the material based upon the signal produced by the radiation detector. The material property gauge includes an electromagnetic moisture property gauge that determines a moisture property of the material. An electromagnetic field generator may generate an electromagnetic field where the electromagnetic field sweeps through one or more frequencies and penetrates into the material. An electromagnetic sensor may determine a frequency response of the material to the electromagnetic field across the several frequencies. | 2015-11-26 |
20150338332 | VISCOSITY MEASURING METHOD AND VISCOSITY MEASURING APPARATUS - A viscosity measuring method and apparatus including (1) a step in which a plunger having an outer radius R | 2015-11-26 |
20150338333 | METHOD FOR MEASURING OPTICALLY TRANSPARENT PARTICLES AND DEVICE FOR MEASURING OPTICALLY TRANSPARENT PARTICLES - The present invention is one that, without performing a complicated measuring process, makes it possible to continuously measure optically transparent particles including a biologically-derived polysaccharide having a negatively-charged functional group, such as transparent exopolymer particles (TEP), and includes: a dyeing step of adding to a sample solution a dye that binds to the negatively-charged functional group of the optically transparent particles to dye the optically transparent particles; an aggregation step of reducing the ionic strength of the sample solution to aggregate the optically transparent particles; and a turbidity measuring step of irradiating inspection light to the dyed and aggregated optically transparent particles, and detecting transmitted light caused by the optically transparent particles to measure the turbidity of the sample solution. | 2015-11-26 |
20150338334 | HETEROGENEOUS FLUID SAMPLE CHARACTERIZATION - The disclosure relates to methods and device for detecting properties of heterogeneous samples, including detecting properties of particles or fluid droplets in industrial processes. A probe may be inserted into a first of multiple heterogeneous fluid samples. A portion of the first sample may be drawn into the probe and past a two-dimensional array detector. The portion of the first sample may be illuminated as it is drawn past the array detector and an image of the portion of the first sample may be acquired. The probe may be inserted into a second of multiple heterogeneous fluid samples. A portion of the second sample may be drawn into the probe and past a two-dimensional array detector. The portion of the second sample may be illuminated as it is drawn past the array detector and an image of the portion of the second sample may be acquired. | 2015-11-26 |
20150338335 | PARTICLE DETECTION APPARATUS AND PARTICLE DETECTION METHOD - A particle detection apparatus and a particle detection method capable of accurately detecting scattered light are provided. A scattered light detection unit of the particle detection apparatus having at least a light illumination unit for illuminating a particle with light and the scattered light detection unit for detecting scattered light emitted from the particle illuminated with light is provided with a first detection portion for detecting scattered light, a second detection portion for detecting illumination light onto a particle, and a signal processing unit for removing a noise component from a signal detected in the first detection portion based on a signal detected in the second detection portion. | 2015-11-26 |
20150338336 | Reflective Transparent Optical Chamber - A chamber configured to increase an intensity of target radiation emitted therein is provided. The chamber includes an enclosure at least partially formed by a set of transparent walls. Each transparent wall can comprise a first material transparent to the target radiation and having a refractive index greater than 1.1 for the target radiation. The outer surface of the set of transparent walls can include a set of cavities, each cavity comprising an approximately prismatic void. Additionally, a medium located adjacent to an outer surface of the set of transparent walls can have a refractive index within approximately one percent of a refractive index of a vacuum for the target radiation. | 2015-11-26 |
20150338337 | DIFFERENTIAL INFRA RED NANOSCOPY SYSTEM AND METHOD - The invention provides a method and system to record the absorption of a sample, said method comprising the steps of providing first and second pulsed beam of light on said sample using one or more light beams, said first and second pulsed beam having different spatial definition; measuring the difference in intensity transmitted through and/or reflected by a sample; and generating an image by scanning the sample while making such measurements. The system and method of the invention can work down to resolution of several 100 of nm, affording thus a large improvement in comparison to synchrotron IR imaging that is the closest technique existing today. The advantage versus scanning probe approach is the absence of physical probe, thus suppressing confinement to surface information and removing uncertainty regarding the working behaviour of the probe. | 2015-11-26 |
20150338338 | Method and Apparatus for Determining Markers of Health by Analysis of Blood - Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time. The methods and apparatus of identifying high blood pressure with biomarkers have the advantage of providing improved treatment of the subject, as the identified biomarker can be related to an effect of the high blood pressure on the subject, such as a biomarker corresponding to central blood pressure. The sample can be subjected to increases in one or more of pressure or temperatures, and changes in the blood sample measured over time. | 2015-11-26 |
20150338339 | CO2 CONCENTRATION SENSOR - Device for measuring the concentration of a predetermined gas, in particular CO2, comprising a cavity, a light source emitting light rays within a basic spectral range including visible and infrared, a detector configured to receive a portion of the light rays within a first predefined spectral range corresponding to high absorption of the predetermined gas, a photodiode configured to receive a portion of the light rays within a second predefined spectral range corresponding to low absorption of the predetermined gas, a control unit configured to calculate the concentration of the predetermined gas by comparing the radiant power received by the detector to the radiant power received by the photodiode. | 2015-11-26 |
20150338340 | METHOD AND APPARATUS FOR MONITORING A LEVEL OF A GASEOUS SPECIES OF INTEREST - Gas measurement detectector configured to monitor a level of a gaseous molecular species within a flow path ( | 2015-11-26 |
20150338341 | A THREE-DIMENSIONAL DISPERSIBLE NANORESONATOR STRUCTURE FOR BIOLOGICAL, MEDICAL AND ENVIRONMENTAL APPLICATIONS AND METHOD FOR MANUFACTURE THEREOF - A three-dimensional nanoresonator structure has a stack of laterally confined layers including at least a first layer and a second layer of different conductive materials between which a dielectric layer is interposed. The layers have at least a respective accessible surface area exposed to an environment in which the structure is immersed. Multiple three-dimensional nanoresonators that can be dispersed in an environment are formed from an array of nanoresonators fixed to a sacrificial substrate. The nanoresonators are subsequently separated from the substrate and conjugated with a chemical agent adapted to promote the formation of a stable colloidal suspension of nanoresonators in a liquid medium. | 2015-11-26 |
20150338342 | GAS ABSORPTION SPECTROSCOPIC SYSTEM AND GAS ABSORPTION SPECTROSCOPIC METHOD - Provided is a gas absorption spectroscopic system and gas absorption spectroscopic method capable of accurately measuring the concentration or other properties of gas even in high-speed measurements. Laser light with a varying wavelength is cast into target gas. A spectrum profile representing a change in the intensity of the laser light transmitted through the target gas with respect to wavelength is determined. For this spectrum profile, polynomial approximation is performed at each wavelength point within a predetermined wavelength width, using an approximate polynomial. Based on the coefficients of the terms in the approximate polynomial at each point, an nth order derivative curve, where n is an integer of zero or larger, of the spectrum profile is created. A physical quantity of the target gas is determined based on the thus created nth order derivative curve. | 2015-11-26 |
20150338343 | Silicon Oil Sensor and Electric Power Terminal Assembly - A silicon oil sensor is provided and includes a transparent member and a laser source emitting a laser beam. The transparent member includes a light receiving passageway with an oil receiving section and a side surface. The laser beam is directed into the light receiving passageway such that an incident angle θ of the laser beam (L) with respect to the side surface is selected so that a total reflection of the laser beam (L) occurs on the side surface when the oil receiving section is filled with air and exits out of the transparent member along a total reflection path (L | 2015-11-26 |
20150338344 | METHODS AND OPTICAL INTERROGATION SYSTEM FOR MONITORING STRUCTURAL HEALTH OF A STRUCTURE - Methods and an optical interrogation system for monitoring structural health of a structure are provided. The method includes generating an optical signal using an optical signal generator, and directing the optical signal towards at least one optical sensor located remotely from the optical signal generator. The optical sensor includes a photonic crystal wafer optically interacting with the optical signal and an environmental condition. The method also includes capturing, by an optical signal receiving apparatus, a reflected optical signal reflected from the at least one optical sensor, and analyzing the reflected optical signal to determine a change in the environmental condition. | 2015-11-26 |
20150338345 | One Dimensional Photonic Crystals for Enhanced Fluorescence Based Sensing, Imaging and Assays - Techniques for enhanced fluorescence include a functionalized substrate for a target optical frequency comprising a one dimensional photonic crystal that is functionalized with a bioactive target molecule that has an affinity for a particular analytic. The one dimensional photonic crystal includes a plurality of dielectric layers including a plurality of high index of refraction layers alternating with a plurality of low index of refraction layers. The thickness of each layer is within a factor of four of a wavelength of the optical frequency in the layer. For emissions from a fluorophore bound to the target molecule and excited by incident light, there is an emission intensity maximum centered at an angle independent of the direction of the incident light. | 2015-11-26 |
20150338346 | Method For Highly Sensitive Detection of Biomarkers for Diagnostics - This disclosure provides, among other things, a nanosensor comprising a substrate and one or a plurality of pillars extending from a surface of the substrate, where the pillars comprise a metallic dot structure, a metal disc, and a metallic back plane. The nanosensor comprises a molecular adhesion layer that covers at least a part of the metallic dot structure, the metal disc, and/or the metallic back plane and a capture agent bound to the molecular adhesion layer. The nanosensor amplifies a light signal from an analyte, when the analyte is specifically bound to the capture agent. | 2015-11-26 |
20150338347 | GLYCAN PROFILING UTILIZING CAPILLARY ELECTROPHORESIS - A method for glycan profiling by capillary electrophoresis (CE), and a CE system for glycan analysis (N-Glycan). The CE system uses integrated dual optical fibers for both radiation excitation and emission detection. The CE system is configured for performing a two-color detection for data analysis. A single radiation excitation source is used to excite two emission fluorophores or dyes in the sample solution to be analyzed. One emission dye is to tag the sample and the other dye is used to provide a reference marker (e.g., a Dextran Ladder) for the sample run. Two detectors (e.g., photomultipler tubes (PMTs)) are applied to simultaneously detect the fluorescent emissions from the dyes. The data collected by both detectors are correlated (e.g., synchronized, and/or super-positioned for analysis) for accurate data peak identification. | 2015-11-26 |
20150338348 | ULTRASENSITIVE SERS FLOW DETECTOR - The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection analysis, electrophoresis, and chromatography. A surface-enhanced Raman scattering (SERS) flow detector capable of ultrasensitive optical detection on the millisecond time scale has been developed. The device employs hydrodynamic focusing to improve SERS detection in a flow channel where a sheath flow confines analyte molecules eluted from a capillary over a planar SERS-active substrate. Increased analyte interactions with the SERS substrate significantly improve detection sensitivity. Raman experiments at different sheath flow rates showed increased sensitivity compared with the modeling predictions, indicating increased adsorption. At low analyte concentrations, rapid analyte desorption is observed, enabling repeated and high-throughput SERS detection. The flow detector offers substantial advantages over conventional SERS-based assays such as minimal sample volumes and high detection efficiency. | 2015-11-26 |
20150338349 | bG METER ILLUMINATED TEST STRIP - A handheld medical device is configured to illuminate a test strip inserted therein and may include a housing having a port configured to receive a test strip. A circuit board may be mounted inside the housing. A measurement module may be mounted to the circuit board and may be cooperatively operable with the test strip inserted into the port to measure a sample of fluid residing on the test strip. The circuit board faces an opposing top surface of the test strip inserted into the port. A light source may be mounted on the circuit board and operable to emit light substantially perpendicular to the opposing top surface of the test strip inserted into the port. The light source may project the light along an optical axis substantially perpendicular to the opposing top surface of the test strip and illuminate an area surrounding a dosing end of the test strip. | 2015-11-26 |
20150338350 | DEVICE FOR MONITORING BIOFILM - The present invention relates to a device for monitoring a biofilm, which can monitor a formation state of the biofilm by using a biofilm shadow image. According to one embodiment of the present invention, the device for monitoring a biofilm can comprise: a water tank for storing water; a monitoring substrate arranged inside the water tank and surface-treated so as to accelerate the biofilm formation; a light-emitting module located at an upper portion of the monitoring substrate so as to emit light in a monitoring substrate direction; and an image sensor unit arranged below the monitoring substrate so as to capture a shadow image of the biofilm, which is formed on the monitoring substrate. | 2015-11-26 |
20150338351 | OPTICAL CHEMICAL ANALYSER AND LIQUID DEPTH SENSOR - An optical chemical analyser comprises a source of a first amount of radiation ( | 2015-11-26 |
20150338352 | INFRARED DETECTOR DEVICE INSPECTION SYSTEM - Methods and apparatuses for identifying carrier lifetimes are disclosed herein. In a general embodiment, a beam of light is sent to a group of locations on a material for an optical device. Photons emitted from the material are detected at each of the group of locations. A carrier lifetime is identified for each of the group of locations based on the photons detected from each of the group of locations. | 2015-11-26 |
20150338353 | OPTICAL INSPECTION SCOPE WITH DEFORMABLE, SELF-SUPPORTING DEPLOYMENT TETHER - Non-destructive evaluation optical inspection systems include video cameras or other reflective-photonic optical instruments, such as laser profilometers or 3D white light laser dimensional scanners, which are incorporated in a camera head. The camera head is coupled to a distal end of a self-supporting and shape-retaining elongate deformable deployment tether. The deployment tether is bendable, for insertion through cavities of power generation machines and orientation of the camera head field of view on the internal area of interest. The deployment tether is capable of being deformed repeatedly, for inspection of different areas of interest. In some embodiments, interchangeable camera heads are selectively coupled to the deployment tether, so that a kit or family of different optical inspection instruments are available to carry out multiple types of inspections within a single or multiple types of power generation machinery. | 2015-11-26 |
20150338354 | Remote Detection and Identification of Nuclear Materials Using Multiple Ion-Chambers - A system and method for detecting and identifying nuclear materials by detecting and measuring positive and negative ions in multiple ion chambers, wherein each ion chamber comprises a different gas, including oxygen, argon, nitrogen, carbon dioxide, and humid air, and one or more ion counters. The ion data can be transmitted to an isotope identification module. The ion data can include a distinctive pattern data of positive-ion production rates and negative-ion production rates generated from the measured positive and negative ions. The isotope identification module can compare the pattern data of positive-ion production rates and negative-ion production rates to an isotope data library, and identify a detected nuclear isotope with the isotope identification module. A display can show the identified detected nuclear isotope; a probability of the presence of the detected nuclear isotope; and a radioactivity of the detected nuclear isotope. | 2015-11-26 |
20150338355 | X-Ray Apparatus for Detecting a Flaw of Small Sized Article Continuously - The present invention relates to an x-ray apparatus for detecting a defect of small-sized articles continuously. The x-ray apparatus comprises an inspection module having an x-ray tube and a detector; a conveying module configured to convey an inspection target within the inspection module continuously; an inputting unit and an outputting unit installed at an entrance and an exit of the inspection module R; a shielding member displaced at an entering portion formed in the inputting unit; and a fixing guide formed in the conveying module. | 2015-11-26 |
20150338356 | AIR SLIDE ANALYZER SYSTEM AND METHOD - Systems and Methods for an air slide analyzer for measuring the elemental content of aerated material traveling by air slide. The air slide analyzer has an analyzer having an entrance opening and an exit opening, and an interior tunnel adapted for aerated material conveyed by an air slide; a radiation detector proximal to the analyzer; a neutron source emitting neutrons into material within the analyzer; and a processor to analyze detected information from the radiation detector, wherein emissions from the material being irradiated with neutrons are detected by the radiation detector and analyzed by the processor to provide elemental information of the material in the analyzer. | 2015-11-26 |
20150338357 | ANALYZING APPARATUS AND CALIBRATION METHOD - In an analyzing apparatus for analyzing compositions using a fluorescent X-ray in the atmosphere, a calibration to eliminate influences caused by a time-dependent change is performed. The analyzing apparatus includes an emission unit, a detection unit, an environment measurement unit, and a time-dependent change calculation unit. The emission unit emits a primary X-ray. The detection unit detects an intensity of a secondary X-ray passing through the atmosphere. The environment measurement unit measures an environment parameter defining the atmosphere. The time-dependent change calculation unit calculates a time-dependent change of the intensity of the secondary X-ray between a first timing and a second timing, based on a first environment parameter, a first intensity of the secondary X-ray, a second environment parameter, and a second intensity of the secondary X-ray. | 2015-11-26 |
20150338358 | Mineral Identification Using Sequential Decomposition into Elements from Mineral Definitions - Mineral definitions each include a list of elements, each of the elements having a corresponding standard spectrum. To determine the composition of an unknown mineral sample, the acquired spectrum of the sample is sequentially decomposed into the standard spectra of the elements from the element list of each of the mineral definitions, and a similarity metric computed for each mineral definition. The unknown mineral is identified as the mineral having the best similarity metric. | 2015-11-26 |
20150338359 | LIQUID QUALITY METER APPARATUS - Embodiments of the present disclosure provide techniques and configurations for an apparatus for providing liquid quality measurements. In one instance, the apparatus may comprise a printed circuit board (PCB) having first and second electrodes associated with the PCB, to directly contact with a liquid to obtain a plurality of electrical parameters of the liquid when electrical current passes between the first and second electrodes while in contact with the liquid, wherein the electrical parameters are associated with quality of the liquid. The PCB may further comprise circuitry disposed thereon and coupled to the first and second electrodes to collect the electric parameters of the liquid. Other embodiments may be described and/or claimed. | 2015-11-26 |
20150338360 | Integrated CMOS Porous Sensor - A single chip wireless sensor comprises a microcontroller and transmit/receive interface, which is coupled to a antenna by an L-C matching circuit. The sensor senses gas or humidity and temperature. The device is an integrated chip manufactured in a process in which the electronics and sensor components are manufactured using CMOS processing techniques, applied to achieve both electronic and sensing components in an integrated process. A Low-K material with an polymer component is spun onto the wafer to form a top layer incorporating sensing electrodes. This material is cured at 300° C., lower than CVD temperatures. The polyimide when cured becomes thermoset, and the lower mass-to-volume ratio resulting in its dielectric constant, reducing to 2.9. The thermoset dielectric, not regarded as porous in the conventional sense, has sufficient free space volume to admit enough gas or humidity for sensing. | 2015-11-26 |
20150338361 | GAS SENSOR AND METHOD FOR DETERMINING A CONCENTRATION OF GAS IN A TWO-COMPONENT MIXTURE - The described sensor allows determination of the concentration of a gas in a two-component mixture at variable pressure by measuring the diffusivity and the thermal conductivity. The sensor is provided to alternately heat the membrane of a thermally conductive cell and allow it to cool such that the temperature T | 2015-11-26 |
20150338362 | Combinatorial screening of metallic diffusion barriers - Barrier layers, barrier stacks, and seed layers for small-scale interconnects (e.g., copper) are combinatorially screened using test structures sputtered or co-sputtered through apertures of varying size. Various characteristics (e.g., resistivity, crystalline morphology, surface roughness) related to conductivity, diffusion blocking, and adhesion are measured before and/or after annealing and compared to arrive at materials and process parameters for low diffusion with high conductivity through the interconnect. Example results show that some formulations of tantalum-titanium barriers may replace thicker tantalum/tantalum-nitride stacks, in some cases with a Cu—Mn seed layer between the Ta—Ti and copper. | 2015-11-26 |
20150338363 | CAPACITIVE FRINGING FIELD SENSORS AND ELECTRICAL CONDUCTIVITY SENSORS INTEGRATED INTO PRINTED CIRCUIT BOARDS - A device is provided for sensing the chemical composition of soils and aqueous solutions. The device includes a capacitive fringing field interdigitated electrode sensor integrated into the printed circuit board and configured to sense an electrical impedance. The device also includes an electrical conductivity sensor integrated into the printed circuit board and configured to sense an electrical conductivity. The sensed electrical impedance and electrical conductivity are indicative of chemical properties. The capacitive fringing field interdigitated electrode sensor may also be used to detect the accumulation of ice. | 2015-11-26 |
20150338364 | MULTIPLE-EXCITATION MULTIPLE-RECEIVING (MEMR) CAPACITANCE TOMOGRAPHY - A method for operating a sensor, including simultaneously exciting a first set of electrodes and sensing an output of each electrode of a second set of electrodes, storing output data corresponding to the output of each electrode of the second set of electrodes in a memory storage device, shifting at least one electrode from the first set of electrodes to the second set of electrodes and at least one electrode from the second set of electrodes to the first set of electrodes, and repeating the simultaneously exciting and sensing, the storing, and the shifting until an output data has been stored for each possible pair of electrodes in the first and second set of electrodes. | 2015-11-26 |
20150338365 | SENSOR - A sensor includes a holder; and an electrode and an electrolyte solution that are placed in the holder, wherein the electrode contains a Pb—Sb alloy. | 2015-11-26 |
20150338366 | ELECTROCHEMICAL TEST STRIP AND MANUFACTURING METHOD THEREOF - The present disclosure illustrates an electrochemical test strip and manufacturing method thereof. In the embodiment, a manufacturing process which is not complex and has well precision and convenience is provided to manufacture the electrochemical test strip for testing human body fluid. A surface metallization layer serves as a conductive signal transmission medium, so that the manufacturing cost can be reduced, and the material can be recovered by dissolving the metal in surface metallization. | 2015-11-26 |
20150338367 | Ion-selective electrodes and reference electrodes with a solid contact having mesoporous carbon - The present description discloses solid-contact (SC) electrodes that use mesoporous carbon such as colloid-imprinted mesoporous (CIM) carbon as the interlayer. The electrodes can be ion-selective electrodes (ISEs) or reference electrodes. The CIM carbon with the interconnected mesopores is used as the intermediate layer between the solid electron conductor, such as gold, and a membrane such as an ionophore-doped ion-selective membrane or a reference membrane. The disclosure includes methods of constructing solid contact electrodes such as SC-ISE or reference electrodes with a CIM carbon interlayer, and methods of using the electrodes to determine the quantity of an analyte in a sample. The description also includes disposable paper-based devices for measuring analytes in a sample. | 2015-11-26 |
20150338368 | ELECTROCHEMICAL SENSOR - An electrochemical ion sensor and a method for sensing a presence of at least one ion species in a solution are provided. The electrochemical sensor includes a solid-state electrolyte medium doped with an organometallic material, having an electrochemical affinity with the ion species, and a pair of electrodes electrically contacting the solid-state electrolyte. The electrochemical sensor also includes an electrical circuit configured to drive the pair of electrodes with an AC electrical excitation and to measure at least one parameter related to a complex electrical impedance of the doped solid-state electrolyte medium in response to the AC electrical excitation. The parameter may be an electrical resistance, an inductance or a combination of both, and represents the presence of the ion species in the solution when the solid-state electrolyte medium is exposed to the solution. | 2015-11-26 |
20150338369 | SENSOR ARRAY MOUNTED ON FLEXIBLE CARRIER - A sensor apparatus is disclosed herein. The sensor apparatus includes a flexible carrier that is elongated along a length of the carrier. The sensor apparatus also includes a plurality of analysis zones carried by the carrier. The analysis zones are spaced-apart from one another along the length of the carrier. The sensor apparatus further includes first and second spaced-apart electrodes carried by the flexible carrier. The first and second electrodes have lengths that extend along the length of the carrier. At least one of the first and second electrodes includes analyte sensing chemistry. The first and second electrodes extending across and contact the plurality of analysis zones. | 2015-11-26 |
20150338370 | ELECTROCHEMICAL SENSOR FOR SENSING NITROUS OXIDE - There is presented an electrochemical sensor ( | 2015-11-26 |
20150338371 | SENSOR ELEMENT FOR DETECTING AT LEAST ONE PROPERTY OF A MEASURING GAS IN A MEASURING GAS SPACE, CONTAINING A GROUND, IMPREGNATED SLIP LAYER - A method for manufacturing a sensor element for detecting (i) a gas component in a measuring gas or (ii) a temperature of the measuring gas includes: introducing at least one functional element into at least one slip at least once in such a way that a slip layer is applied to the functional element, the functional element including at least one solid electrolyte and at least one functional layer; sintering the slip layer on the functional element; grinding the slip layer at least in the area of the at least one functional layer; impregnating the slip layer; and thermally treating the impregnated slip layer. | 2015-11-26 |
20150338372 | Electrowetting Dispensing Devices and Related Methods - A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting. | 2015-11-26 |
20150338373 | Electrowetting Dispensing Devices and Related Methods - A method for dispensing liquid for use in biological analysis may comprise positioning liquid to be dispensed via electrowetting. The positioning may comprise aligning the liquid with a plurality of predetermined locations. The method may further comprise dispensing the aligned liquid from the plurality of predetermined locations through a plurality of openings respectively aligned with the predetermined locations. The dispensing may be via electrowetting. | 2015-11-26 |
20150338374 | ION MOBILITY SPECTROMETER AND METHOD OF OPERATING SAME - In a drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a method of separating ions as a function of ion mobility includes repeatedly, and alternating between at least two different time durations, establishing electric drift fields in the drift tube segments and in some of the ion elimination regions while establishing electric repulsive fields in others of the ion elimination regions such that ions having a predefined mobility or range of mobilities are transmitted through the drift tube at one or more frequencies which include one or more overtones of a fundamental frequency at which ions having the predefined mobility or range of mobilities are transmitted through the drift tube with the electric drift fields and electric repulsive fields repeatedly established with uniform time durations. | 2015-11-26 |
20150338375 | MICROSECOND TIME-RESOLVED MASS SPECTROMETRY - A microsecond time-resolved mass spectrometry device and method of using desorption electrospray ionization ( | 2015-11-26 |
20150338376 | METHOD AND APPARATUS FOR MEASURING AN AMOUNT OF SUPERPARAMAGNETIC MATERIAL IN AN OBJECT - Method and apparatus for measuring an amount of superparamagnetic material in an object, the method including a) applying a magnetic field having a first component alternating with a first period to the object and a magnetic field strength lower than a magnetic field strength at which the superparamagnetic material is driven in saturation; b) measuring a first magnetic susceptibility of the object with a detection coil; c) applying a static second component to the magnetic field for a second period being equal or larger than the first period, the strength of the magnetic field during the second period is such that the superparamagnetic material is driven towards saturation; d) measuring a second magnetic susceptibility of the object with the detection coil during the application of the static second component; and e) determining the amount of superparamagnetic material from a difference between the measured first and second susceptibility of the object. | 2015-11-26 |
20150338377 | Eddy Current Inspection Probe - A device and method of eddy current based nondestructive testing of tubular structures made of electrically conductive materials is disclosed. The probe includes means for producing an electromagnetic field for inducing an eddy current in a device under test, means for sensing eddy current signals in the device under test, and an analog to digital converter, wherein the analog to digital converter is conditioned to receive the sensed eddy current signals and to transmit a digital signal related to the eddy current signals. | 2015-11-26 |
20150338378 | ULTRASONIC SIGNAL TIME-FREQUENCY DECOMPOSITION FOR BOREHOLE EVALUATION OR PIPELINE INSPECTION - In some embodiments, methods, apparatus, and systems may operate to launch acoustic waves along a first acoustic path length from an acoustic transducer. The apparatus receives a reflected signal in response to each acoustic wave, each reflected signal including at least one echo. The reflected signal is decomposed, using a time-frequency decomposition method with basis functions, into a wavelet associated with each echo. Parameters describing each associated wavelet are determined and a borehole evaluation or pipeline inspection is performed based on the parameters. | 2015-11-26 |
20150338379 | DEVICE AND SYSTEM FOR AND A METHOD OF MONITORING A CABLE FOR A PHYSICAL DISTURBANCE - A device, system and method for monitoring a cable for a physical disturbance is disclosed. The device includes at least one pair of acoustic transducers, the pair comprising a first acoustic conductor monitoring transducer and a second ambient transducer. The acoustic conductor monitoring transducer is in acoustic contact with an acoustic conductor to be monitored by the device, with the transducers being arranged such that an ambient acoustic signal is common to both transducers. The device further includes a circuit element, with each transducer being connected to an input of the circuit element, the circuit element being arranged to output a difference between the input signals from the transducers. An alarm triggering module is connected to an output of the circuit element, the module being operable to trigger an alarm when the output signal received from the circuit element exceeds a predefined threshold value. | 2015-11-26 |
20150338380 | Assessing Corrosion Damage in Post-Tensioned Concrete Structures Using Acoustic Emission - Methods are provided for detecting damage in a post-tensioned concrete specimen due to corrosion. In one embodiment, the method comprises mounting at least two piezoelectric sensors onto the surface of the post-tensioned concrete specimen; receiving acoustic emission signals at the piezoelectric sensors; recording the acoustic emission signals with associated parameters and waveforms; and filtering the data for example using Root Mean Square data and the average frequency data. | 2015-11-26 |
20150338381 | ULTRASOUND TRANSDUCER WITH REDUCED APERTURE DELAY LINE - A delay line for an ultrasound transducer including: upper and lower surfaces, wherein the upper surface is configured to engage with an ultrasonic transducer and the lower surface is configured to engage with an object to be tested and the upper and lower surfaces have an area that is smaller than an area of the ultrasonic transducer; and at least one attachment face configured to attach to the ultrasound transducer. A method of applying ultrasonic energy to an object, the method including: applying a delay line to an object, wherein the delay line has: upper and lower surfaces, wherein the upper surface is configured to engage with an ultrasonic transducer and the lower surface is configured to engage with an object to be tested and the upper and lower surfaces have an area that is smaller than an area of the ultrasonic transducer; and at least one attachment face configured to attach to the ultrasound transducer; generating ultrasonic pulses via a transducer attached to the delay line; determining measurements based on the ultrasonic pulses; and determining characteristics of the object based on the measurements. | 2015-11-26 |
20150338382 | GAS CHROMATOGRAPHIC (GC) UNIT, SCALABLE GC SYSTEMS USING SAME, AND RELATED METHODS - A gas chromatographic (GC) unit or module may include one or more microfluidic devices, a GC column, and a flow controller (FC) comprising an FC input port for controlling fluid flows and pressures. The GC unit may be reconfigurable to provide different functionalities. The GC unit may be fluidly coupled to various other fluidic devices, such as other GC units, sample inlets, GC detectors, and the like. Multiple GC units and other fluidic devices may be utilized to build GC devices and associated systems of flexible, reconfigurable, and scalable architecture, thereby enabling a variety of modes of operation useful for present and future GC method development. | 2015-11-26 |
20150338383 | Frits for Chromatography - Frits for use in analytical instrument systems, including liquid chromatography systems, particularly HPLC and UHPLC systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces. | 2015-11-26 |
20150338384 | IONIZATION OF ANALYTE MOLECULES COMPRISED IN A FLOW OF GAS - An apparatus for ionizing analyte molecules comprised in a flow of a first gas. The apparatus includes an inlet tube through which the first gas may be discharged into an ionization region. The apparatus also includes a nozzle electrode disposed around the inlet tube to define a substantially annular space between the exterior of the inlet tube and the interior of the nozzle electrode. The sheath tube includes an inlet for introducing a fluid into the substantially annular space and an outlet through which the fluid may be discharged into the ionization region. The apparatus is configured to ionize the analyte molecules optionally via electrospray or chemical ionization. | 2015-11-26 |
20150338385 | COVER DEVICE WITH ODOR DETECTOR AND ELECTRONIC DEVICE HAVING THE SAME - A cover device including: a rear cover; a front cover rotatable with respect to the rear cover; and an odor detection module mounted to the front cover. | 2015-11-26 |
20150338386 | Generator Predictive Engine Oil Life Algorithm - A system including one or more generators predicts engine oil life. Generator data is received or generated by a controller. The generator data describes the operation of the generator including a load placed on the generator. Engine data may also be received or generated by the controller describing an engine coupled to the generator. The controller calculates an estimated oil life based at least on the generator data and/or the engine data. | 2015-11-26 |
20150338387 | SUPPLEMENTS AND MONITORING SYSTEMS FOR DOSING OF THE SUPPLEMENTS - Methods for monitoring and adjusting a physiological state of a subject. The methods include (1) providing a subject having one or more physiological parameters defined by one or more biometrics, (2) monitoring a selected biometric analyte associated with a selected biometric to define a state of the selected biometric, (3) based on the results of the monitoring, adjusting the state of the selected biometric by administering to the subject a supplement selected to affect the state of the selected biometric. | 2015-11-26 |
20150338388 | SAFETY KIT FOR TREATING BIOLOGICAL MATERIAL - Safety kit for treating biological material for treating venous blood, adapted to facilitate the transfer of blood from a common syringe to a common collection test tube, the latter having at its interior a predefined vacuum or inert atmosphere, including at least one tubular protection casing, preferably cylindrical, at least one component assemblable or already assembled inside the protection casing. The protection casing and the component, when assembled, adapted to constitute the connection element between the syringe and the collection test tube, and at least one package adapted to contain the components of the kit, wherein the protection casing has at least two portions both portions with equivalent extension and adapted to receive the component, the component having at least two projections the projection extended through the portion and the projection extended into the portion and respectively adapted to connect with the syringe and with the collection test tube. | 2015-11-26 |
20150338389 | DIAGNOSING MULTIPLE SCLEROSIS - There is provided an in vitro method for diagnosing Multiple Sclerosis (MS) in a human test subject, comprising (i) determining the concentrations of two or more metabolites in a sample from said subject, wherein said two or more metabolites are selected from: blood metabolites, wherein said blood metabolites comprise: alanine, ascorbic acid, choline, fatty acid, glucose, lactate, N-acetyl aspartate, N-acetyl glycoprotein, n-butyrate, oxyglutaric acid, phosphocholine, taurinebetaine, tyrosine, L-glutamine, N-acetyl species, and beta-hydroxybutyrate; and/or urine metabolites, wherein said urine metabolites comprise: citrate, creatinine, inositol, lactate and trimethylamine N-oxide (TMAO); (ii) comparing the concentrations of said two or more metabolites in the sample with the concentrations of the same metabolites in at least one reference standard; and (iii) identifying a concentration difference for each of said two or more metabolites in the sample relative to the reference standard; wherein said concentration differences correlate with the presence of MS. | 2015-11-26 |
20150338390 | Device for Measurement of Exhaled Nitric Oxide Concentration - Described is a personal device and methods for measuring the concentration of an analyte in a sample of gas. The device and method may utilize a chemically selective sensor element with low power consumption integrated with circuitry that enables wireless communication between the sensor and any suitable electronic readout such as a smartphone, tablet, or computer. In preferred form, the sensor circuitry relies upon the quantum capacitance effect of graphene as a transduction mechanism. Also in preferred form, the device and method employ the functionalization of the graphene-based sensor to determine the concentration of nitric oxide in exhaled breath. | 2015-11-26 |
20150338391 | IN VITRO DIAGNOSTIC METHOD FOR AN INVASIVE FUNGAL INFECTION USING MALDI-TOFF MASS SPECTROMETRY - A method for the in vitro diagnosis of an invasive fungal infection by MALDI-TOF mass spectrometry. The method involves, providing a liquid biological sample from a mammal, said biological sample containing, in particular, proteins and/or lipids and/or salts and/or polysaccharides and/or oligosaccharides and/or monosaccharides capable of forming complexes with said proteins and/or lipids and/or salts; treating said sample with biological liquid so as to extract said polysaccharides and/or oligosaccharides and/or monosaccharides; determining, by MALDI-TOF mass spectrometry, whether or not there is present among said extracted polysaccharides, oligosaccharides and/or monosaccharides, at least one given compound of interest coming from said fungal microorganism and chosen from polysaccharides, oligosaccharides and monosaccharides; and deducing, if said given compound of interest is present in said sample, that said mammal is suffering from an invasive fungal infection. | 2015-11-26 |
20150338392 | Sterile and instantly dissolvable drug membrane and method thereof for testing drug sensitivity of antineoplastic drugs - A sterile and instantly dissolvable drug membrane, a method thereof for testing drug sensitivity of antineoplastic drugs, and an application thereon in testing drug sensitivity of antineoplastic drugs are provided, wherein the method for testing drug sensitivity of antineoplastic drugs includes steps of: dissolving an antineoplastic drug in a cell culture fluid comprising tumor cells, in such a manner that the antineoplastic drug fully contacts with the tumor cells; wherein the antineoplastic drug is prepared into a sterile and instantly dissolvable drug membrane for being dissolved in the cell culture fluid. According to the present invention, the antineoplastic drug is prepared into a sterile and instantly dissolvable drug membrane for testing drug sensitivity of the antineoplastic drugs, which improves operation efficiency, flexibility, accuracy and economy of drug sensitivity test of the antineoplastic drugs. | 2015-11-26 |
20150338393 | METHODS FOR TREATING NEURAL CELL SWELLING - A composition comprising a novel Ca | 2015-11-26 |
20150338394 | Induction of a parasitemia and preventing neuroinflammation by binding cholinergic receptors in apicomplexan infections using levamisole HCl - Equine protozoal myeloencephalitis (EPM) is the most commonly diagnosed infectious neuro-degenerative in horses. Important advances have been made in the biology of | 2015-11-26 |
20150338395 | METHOD OF PRODUCING LABELED ANTIBODY - A method of producing a labeled antibody, including the steps of:
| 2015-11-26 |
20150338396 | GLYCOFORM DETECTION METHOD AND GLYCOFORM DETECTION DEVICE - It is intended to develop and provide a method for detecting a particular glycan-isoform rapidly and specifically by a small number of steps. The present invention provides a glycan-isoform detection method comprising quantifying an immune complex formed by the mixing of a test sample with a sugar chain non-reducing terminal residue-binding lectin and an antibody specifically binding to the protein moiety of the glycan-isoform, etc., comparing the obtained amount of the immune complex with the amount of a control immune complex obtained when a control sample is not mixed with the sugar chain non-reducing terminal residue-binding lectin or is mixed with a control protein, and determining the presence or absence of the glycan-isoform of interest in the test sample on the basis of the difference between these amounts. | 2015-11-26 |
20150338397 | Use of Bufodienolides in Diagnosing and Treating Essential Hypertension - Certain embodiments are directed to methods of identifying patients with essential by detecting elevated levels of marinobufagenin (MBG) and treating the same with anti-MBG agents. | 2015-11-26 |
20150338398 | METHODS AND KITS FOR ISOLATION AND ANALYSIS OF A CHROMATIN REGION - The present invention encompasses methods of identifying proteins and protein modifications of proteins specifically associated with a chromatin. | 2015-11-26 |
20150338399 | METHODS FOR DIAGNOSING AND MONITORING DISEASE BY DIRECTLY QUANTIFYING DISEASE MODIFIED BIOMOLECULES - Assays for diagnosing or monitoring a disease of interest are provided. The assays detect disease modified bjomolecules (DMBs) in a direct manner by the sequential use of agents with differing specificities. In an exemplary embodiment, the agents are antibodies and the first antibody is specific for a biomolecule that may be modified during the course of 10 the disease, and detects such biomolecules, whether modified or not The second antibody detects only biomolecules that have been modified. | 2015-11-26 |
20150338400 | OPTICAL SENSOR, DETECTION METHOD USING OPTICAL SENSOR, METHOD FOR AFFIXING CAPTURE BODY, AND INSPECTION UNIT - The optical sensor includes a first metal layer having top and a bottom faces, a second metal layer having top and bottom faces, and a hollow area sandwiched by the first metal layer and the second metal layer. A capturing body for capturing a target substance to be detected can be disposed in the hollow area. Thicknesses of the first metal layer and the second metal layer are both not less than 5 nm and not greater than 50 nm. The hollow area includes a determining part for determining the presence of the target substance contained in a specimen. The second metal layer can transmit an electromagnetic wave from the bottom face to the top face. The first metal layer can transmit the electromagnetic wave from the bottom face to the top face. | 2015-11-26 |
20150338401 | MULTIPLEXED BIOASSAY TECHNIQUES - Techniques for multiplexed bioassays include a substrate in which is formed a microchannel in fluid communication between an entry port and an exit port. A first portion of the microchannel is configured to supply multiple different labeled probes, each selected to complex with one of a corresponding plurality of different analytes. A second portion of the microchannel comprises multiple corresponding different supplementary probes covalently bound to the substrate. A supplementary probe is selected to bind to a part of a corresponding analyte, which part is exposed when the corresponding analyte is complexed with a corresponding labeled probe. The techniques include a sensor configured to detect signals emitted from the labeled probes in the second portion of the microchannel. | 2015-11-26 |
20150338402 | Tamm Structures for Enhanced Fluorescence Based Sensing, Imaging and Assays - Techniques for enhanced fluorescence include a Tamm substrate for a target optical frequency comprising a metal nanoscale layer deposited on a Bragg grating. The Bragg grating includes multiple dielectric layers including multiple high index of refraction layers alternating with multiple low index of refraction layers. The dielectric layers are parallel to the metal nanoscale layer; and, the thickness of each dielectric layer is about a fourth of a wavelength of the target optical frequency in the layer. The metal nanoscale layer is configured to host a fluorophore such that an S polarized emission from the fluorophore at the target optical frequency propagates out of the substrate perpendicular to the plurality of dielectric layers. | 2015-11-26 |
20150338403 | EMBODIMENTS OF A COMPOSITION COMPRISING DIATOM FRUSTULES AND A METHOD OF USING - A composition comprising a diatom frustule and a metal coating, and a method for making the same, are disclosed herein. The metal coating may comprise a metal film or metal nanoparticles, which may be attached to the surface via a linker. The composition has a surface coverage ratio of from about 1% to about 100%. The composition may also comprise an antibody. Also disclosed is a method for using the composition comprising contacting the composition with a target molecule, exposing the composition to light, and measuring the resulting Raman scattering. | 2015-11-26 |
20150338405 | VACCINES AND DIAGNOSTICS FOR THE EHRLICHIOSES - The present invention concerns VLPT immunoreactive compositions for | 2015-11-26 |
20150338406 | IMMUNOREACTIVE GLYCOPROTEIN GP19 OF EHRLICHIA CANIS - The present invention concerns gp19 immunoreactive compositions for | 2015-11-26 |
20150338407 | ELISPOT METHOD HAVING TWO FILTER SYSTEMS - An ELISPOT method of in vitro diagnosis of tuberculosis includes enriching or separating liquid blood fraction from its cellular components including visualizing immunocompetent cells by detecting different dyes and using at least two different filter sets, each including one narrowband excitation filter and one narrowband blocking filter, wherein the narrowband excitation filter is transmissive for light provided for luminescent excitation of a respective dye and the narrowband blocking filter is transmissive for light emitted by a respective dye and measuring the number of immunocompetent cells that secrete at least interferon-γ and interleukin-2 as a reaction to an antigen by superimposing at least two two-dimensional images generated during visualization to avoid luminescence of different dyes interfering and strong luminescence being superimposed on weak luminescence. | 2015-11-26 |
20150338408 | SINGLE STEP CALIBRATION CURVE THROUGH SAMPLE CONVECTION - This disclosure relates to methods and apparatuses for simultaneous measurement of multiple analytes in samples. This disclosure relates to methods and apparatuses for determining the concentration of one or more analytes in a fluid sample without use of a calibrant. | 2015-11-26 |
20150338409 | Markers for Abnormal Cells - The present invention relates to methods of determining the presence or absence of abnormal lymphoid cells or abnormal myeloid cells in a cell sample, with the methods comprising subjecting the cell sample to conditions that will activate any inactive matriptase present in the cell sample and measuring the levels of activated matriptase in the cell sample. Once measured, these levels can then be compared to control levels of active matriptase to determine if the cell sample has elevated levels of activated matriptase over control levels of active matriptase. An elevation in the levels of activated matriptase in the cell sample is indicative that the cell sample contains abnormal lymphoid cells or abnormal myeloid cells. | 2015-11-26 |
20150338410 | COMPETITION BASED-DETECTION ASSAYS - Disclosed herein are methods and kits which are useful for detecting presence of an enzyme and the relative amount of glycan associated with the enzyme in a test sample based upon the enzyme's ability to competitively inhibit the binding of a ligand in such test sample. The present invention provides the ability to evaluate cell culture conditions and optimize the desired glycoform content of recombinantly prepared enzymes. | 2015-11-26 |
20150338411 | BIOMARKER FOR THE PREDICTION OF RESPONSIVENESS TO AN ANTI-TUMOUR NECROSIS FACTOR ALPHA (TNF) TREATMENT - The invention refers to a method for diagnosing an individual who is to be subjected to or is being subjected to an anti-tumour necrosis factor alpha (TNFα or TNF) treatment to asses the responsiveness to an anti-TNF treatment which comprises the detection of immunoglobulin(s) against one or more biomarker proteins in a bodily fluid or an excrement of said patient, and sorting the individual into one of two categories based on detection of said immunoglobulin(s), wherein individuals are classified as NON-responder or responder. The invention refers to diagnostic kits comprising said one or more biomarker proteins and the use of these kits for assessing the responsiveness to an anti-TNF treatment of an individual who is to be subjected to or is being subjected to an anti-TNFα treatment. | 2015-11-26 |
20150338412 | COMPOSITION FOR DIAGNOSIS OF LUNG CANCER AND DIAGNOSIS KIT FOR LUNG CANCER - A method of diagnosing small cell lung cancer comprises: measuring an expression level of serum paraoxonase 1 protein and a fucosylation level of the serum paraoxonase 1 protein in a biological sample from a small cell lung cancer patient and in a same biological sample from a normal person, and determining the expression level of the serum paraoxonase 1 protein is decreased in the biological sample of the small cell lung cancer patient as compared to the biological sample of a normal person, and the fucosylation level of the serum paraoxonase 1 protein is increased in the biological sample of the small cell lung cancer patient as compared to the biological sample of a normal person. The measuring of the fucosylation of the serum paraoxonase 1 protein comprises using a biotinylated lectin which binds specifically to fucose on the serum paraoxonase 1 protein and HRP-conjugated streptavidin in a hybrid ELISA. | 2015-11-26 |
20150338413 | SYSTEM AND METHOD FOR ANALYSIS OF BIO-METABOLITES FOR-USE IN IMAGE-GUIDED SURGERY - A system for identifying a bio-marker using mass spectroscopy is provided that includes a sample receptacle configured to receive a tissue sample, a mass spectrometry apparatus configured to receive the tissue sample and analyze the tissue sample using a mass spectrometry process to generate mass spectrometry data, and a computer system that includes a computer processor having access to a non-transitory, computer-readable storage medium having stored thereon instructions. The instructions cause the computer processor to: receive the mass spectrometry data from the mass spectrometry apparatus; analyze the mass spectrometry data to determine a presence of 2-Hydroxyglutarate (2-HG) in the tissue sample; and generate a report indicating a health of the tissue sample based on the presence of 2-HG in the tissue sample. | 2015-11-26 |
20150338414 | UREA-BASED SYNTHETIC URINE AND METHOD OF MANUFACTURING SAME - A synthetic urine solution and method of its manufacture are disclosed. The solution includes water having a pH between about 3 and about 10. The solution further includes creatinine, a means for removing bacteria from the solution so as to control or eliminate sepsis of the urine solution, preferably through the use of a biocide, and a urea-based compound. The solution exhibits a specific gravity of from 1.005 g/cm | 2015-11-26 |
20150338415 | MEANS AMD METHODS APPLYING sFlt-1/PIGF OR ENDOGLIN/PIGF RATIO TO RULE OUT ONSET OF PREECLAMPSIA WITHIN A CERTAIN TIME PERIOD - The present invention concerns the field of diagnostic assays for prenatal diagnosis of preeclampsia. In particular, it relates to a method for diagnosing whether a pregnant subject is not at risk for preeclampsia within a short window of time comprising a) determining the amount of at least one angiogenesis biomarker selected from the group consisting of sFlt-1, Endoglin and PlGF in a sample of said subject, and b) comparing the amount with a reference, whereby a subject being not at risk for developing preeclampsia within a short period of time is diagnosed if the amount is identical or decreased compared to the reference in the cases of sFlt-1 and Endoglin and identical or increased in the case of PlGF, wherein said reference allows for making the diagnosis with a negative predictive value of at least about 98%. Further contemplates are devices and kits for carrying out said method. | 2015-11-26 |
20150338416 | ORDERED TWO- AND THREE-DIMENSIONAL STRUCTURES OF AMPHIPHILIC MOLECULES - The invention pertains, at least in part, to a method for forming an ordered structure of amphiphilic molecules, such as proteins. The method includes contacting a population of amphiphilic molecules with an interface; compressing said population laterally to an appropriate pressure, such that an ordered structure at the interface is formed. The invention also pertains to the two- and three-dimensional ordered structures that are formed using the planar membrane compression method of the invention. | 2015-11-26 |
20150338417 | BINDING DOMAIN MAPPING - The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions. | 2015-11-26 |
20150338418 | METHODS FOR MASS SPECTROMETRIC BIOPOLYMER ANALYSIS USING OPTIMIZED OLIGOMER SCHEDULING - A method for detecting a list of known biopolymer molecules comprises: calculating, for each biopolymer, a respective list of oligomer molecules predicted to be produced by chemical processing; calculating, for each oligomer molecule, a respective predicted chromatographic elution time period; assigning, for each biopolymer molecule, one or more selected oligomer molecules to be detected, wherein the selecting is performed using weighted selection probabilities determined from the predicted elution times; scheduling a plurality of oligomer detection events of a detection system, wherein each oligomer detection event corresponds to a respective one of the predicted elution time periods; performing the chemical reaction or processing of the sample to generate a processed sample; introducing the processed sample into a chromatographic system; introducing any eluting oligomers into the detection system; and operating the detection system so as to search for each of the selected oligomer molecules in accordance with the scheduled detection events. | 2015-11-26 |
20150338419 | Method for the Determination of Biomolecule Turnover Rates - Disclosed is a method for determining the turnover rate of biomolecules in a subject, which include administering to the subject, 2H20 in an amount sufficient to label biomolecules in the subject with 2H. Samples are collected from the subject at one or more time points and isotopomers are detected for the labeled biomolecules in the samples. The fractional abundance is determined for the isotopomers of the biomolecules in the samples and the biomolecule turnover rates of the one or more labeled biomolecules is determined based on the fractional abundance of the isotopomers. A computer-implemented method is also disclosed for determining the turnover rate of one or more biomolecules in subject. In certain other embodiments, a system for determining protein turnover rates in a subject is also provided. Also provided in certain embodiments is a computer program product for determining protein turnover rates in a subject. | 2015-11-26 |
20150338420 | DIAGNOSTIC METHOD FOR DETERMINING THE PRESENCE AND AMOUNT OF HUMAN INTERLEUKIN-3 IN A SAMPLE USING NOVEL IL-3 ANTIBODIES - For determining the presence and amount of human IL-3 in a sample, the present invention provides a diagnostic method, wherein an anti-IL-3- antibody, fr agment or construct thereof is added to said sample under conditions which allow for binding said antibody, fragment or construct thereof to IL-3 and detecting the amount of antibody bound IL-3 in said sample, wherein the anti-IL-3-antibody is clone 13. Further subject matter of the present invention are the novel antibody clone 13, a nucleic acid encoding said antibody and a hybridoma cell line which produces antibody clone 13. A diagnostic assay kit contains all necesary reagents and materials for performing such assay, preferably an ELISA assay and especially preferably contains antibody clones 13 and 11. | 2015-11-26 |
20150338421 | NON-INVASIVE DIAGNOSTIC METHOD FOR THE EVALUATION OF INTESTINAL LACTASE DEFICIENCY (HYPOLACTASIA) - The test of the invention comprises the measuring the total amount of xylose in urine and/or its concentration in blood following oral administration of 4-Oβ-D-galactopyranosyl-D-xylose (4-GX) to the patient. It is a non-invasive test that is based on the direct evaluation of the global enzyme activity in the whole individual, not on measuring the metabolic consequences derived from its deficiency. It does not require specialised equipment, does not cause apparent discomfort in patients with lactase deficiency and is very reliable, thus overcoming the drawbacks of the diagnostic tests currently in use and is a statistically significantly better test in terms of its reliability; consequently it should become the reference or gold standard test for the indication of hypolactasia. | 2015-11-26 |
20150338422 | METHOD FOR OBTAINING DATA THAT ARE USEFUL FOR THE DIAGNOSIS, PROGNOSIS AND CLASSIFICATION OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND/OR LUNG CANCER - The invention describes a method for obtaining data useful for the diagnosis, prognosis and classification of individuals with chronic obstructive pulmonary disease (COPD) and/or lung cancer, diagnostic kit, device and uses thereof for the diagnosis, prognosis and classification of patients as a) individuals with no COPD or lung cancer, b) individuals with COPD, c) individuals with adenocarcinoma, d) individuals with COPD and adenocarcinoma, or e) individuals with COPD and squamous carcinoma | 2015-11-26 |
20150338423 | METHODS FOR DETERMINING RELATIVE BINDING ENERGY OF MONOMERS AND METHODS OF USING THE SAME - Disclosed herein are monomers that exhibit reduced estradiol related receptor binding activity, and methods for identifying monomers that exhibit reduced estradiol related receptor binding activity. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. | 2015-11-26 |
20150338424 | APPARATUS AND METHOD FOR PLATELET FUNCTION AND DRUG REPSONSE TESTING BASED ON MICROFLUIDIC CHIP - The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased. | 2015-11-26 |
20150338425 | TREATMENT AND PROGNOSIS OF LYMPHANGIOLEIOMYOMATOSIS - Embodiments disclosed herein relate to treatment methods, diagnosis methods, drug efficacy evaluation methods and prognosis evaluation methods of lymphangioleiomyomatosis (LAM) and a disease associated with a mutation in a tuberous sclerosis complex (TSC) gene. The methods comprising analyses of the levels of lysophosphatidylcholine (LPC) in a biological sample of a subject, or comprising analyses of images of the location and signal intensity of isotope-labeled choline in the subject. | 2015-11-26 |