48th week of 2021 patent applcation highlights part 33 |
Patent application number | Title | Published |
20210371868 | FLOWERING TIME-REGULATING GENE CMP1 AND RELATED CONSTRUCTS AND APPLICATIONS THEREOF - Isolated polynucleotides and polypeptides, and recombinant DNA constructs and CRISPR-Cas constructs useful for regulating plant heading date or flowering time are provided, and methods utilizing these recombinant DNA constructs and CRISPR-Cas constructs are also provided. Compositions comprising these recombinant DNA constructs or a modified endogenous CMP1 gene are further provided. | 2021-12-02 |
20210371869 | TRANSCRIPTION FACTOR NtERF241 AND METHODS OF USING THE SAME - The present technology provides transcription factors for modifying plant metabolism and nucleic acid molecules that encode such transcription factors. Also provided are methods of using these nucleic acids to modulate alkaloid production in plants and for producing plants and cells having altered alkaloid content. | 2021-12-02 |
20210371870 | DOMINANT-NEGATIVE GENETIC MANIPULATION TO MAKE LOW-NICOTINE TOBACCO PRODUCTS - The present technology provides dominant negative forms of transcription factors for modifying nicotine biosynthesis and nucleic acid molecules that encode such dominant negative transcription factors. Also provided are methods of using these nucleic acids to modulate nicotine production in plants and for producing plants and plant cells having reduced nicotine content. | 2021-12-02 |
20210371871 | Pleiotropic Gene that Increases Biomass and Sugar Yield in Sorghum and Sugarcane - A method for increasing biomass and sugar yield of a plant comprising: transforming a plant with a first gene that is functional in a plant, wherein said gene is pleitropic, and wherein said plant overexpresses said gene, thereby increasing biomass and sugar yield; producing said plant through molecular breeding using information of said gene; and cultivating said plant. | 2021-12-02 |
20210371872 | ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USING SAME FOR INCREASING PLANT YIELD, BIOMASS, GROWTH RATE, VIGOR, OIL CONTENT, ABIOTIC STRESS TOLERANCE OF PLANTS AND NITROGEN USE EFFICIENCY - Provided are isolated polynucleotides encoding a polypeptide at least 80% homologous to the amino acid sequence selected from the group consisting of SEQ ID NOs: 757, 456-756, 758-774, 8385-10836, and 10838-14462; and isolated polynucleotide comprising nucleic acid sequences at least 80% identical to SEQ ID NO: 377, 1-376, 378-455, and 775-8384. Also provided are nucleic acid constructs comprising same, isolated polypeptides encoded thereby, transgenic cells and transgenic plants comprising same and methods of using same for increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. | 2021-12-02 |
20210371873 | METHODS FOR CONTROLLING MERISTEM SIZE FOR CROP IMPROVEMENT - This invention relates to compositions and methods for modifying CORYNE (CRN) genes in plants to optionally increase kernel row number and/or improve one or more yield traits. The invention further relates to plants having increased kernel row number and/or one or more improved yield traits produced using the methods and compositions of the invention. | 2021-12-02 |
20210371874 | Gene PpHSP21 with black spot disease resistance in Pyrus pyrifolia and its applications in improving black spot disease resistance in plants - A gene PpHSP21 with black spot disease resistance is isolated from | 2021-12-02 |
20210371875 | A CELL SURFACE TAG EXCHANGE (CSTE) SYSTEM FOR TRACING AND MANIPULATION OF CELLS DURING RECOMBINASE MEDIATED CASSETTE EXCHANGE INTEGRATION OF NUCLEIC ACID SEQUENCES TO ENGINEERED RECEIVER CELLS - A combined system comprising two separate components, wherein the first component is a tag-exchange donor vector (TEDV) encoding a first cell surface tag (CST) exon flanked by a 3′ intron fragment, and a gene of interest (GOI) in the antisense orientation, and the second component is an engineered cell containing within its genome a tag-exchange receiver site (TERS), encoding a second CST exon adjoined by a full intron sequence to an exon encoding a transmembrane domain, and also encoding a reporter gene in the antisense orientation, wherein paired recombinase mediated cassette exchange (RMCE) elements are included in the TEDV and TERS such that execution of RMCE between the TEDV and TERS results in exchange of the reporter element for the GOI encoded by the TEDV, and exchange of the first CST exon for the second CST exon, such that the derivative engineered cell now expresses the first CST and GOI, in place of the second CST and the reporter gene. | 2021-12-02 |
20210371876 | PORCINE THY1 GENE PROMOTER SPECIFICALLY EXPRESSED IN NEURONS - A Thy1 gene promoter specifically expressed in neurons and a recombinant vector including the Thy1 gene promoter are provided. The Thy1 gene promoter may be utilized to regulate an expression of a target gene in preparation of an animal model similar to a human. | 2021-12-02 |
20210371877 | ADENO-ASSOCIATED VIRUS (AAV) VECTOR LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF USE - A composition includes an adeno-associated vims (AAV) vector in a lipid nanoparticle (LNP). The AAV vector can include a heterologous nucleic acid sequence, optionally an inverted terminal repeat (ITR) positioned 5′ of the heterologous nucleic acid sequence and an ITR positioned 3′ of the heterologous nucleic acid sequence. The AAV vector can further include expression control elements (e.g., a promoter and/or enhancer), and intron, and/or or a polyadenylation signal. | 2021-12-02 |
20210371878 | INTEIN PROTEINS AND USES THEREOF - The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb. | 2021-12-02 |
20210371879 | ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSIDS AND METHODS OF USE THEREOF - The present disclosure provides recombinant adeno-associated virus (AAV) virions comprising: a) a variant capsid protein; and b) a heterologous nucleic acid comprising one or more nucleotide sequences encoding one or more heterologous gene products. The rAAV virions are useful for delivery of gene products to a retinal cell. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual. | 2021-12-02 |
20210371880 | RECOMBINANT ADENO-ASSOCIATED VECTORS - Adeno-associated virus (AAV) vectors and uses thereof are provided. More specifically, AAV vectors are provided that show specific tropism for certain target tissue, such as central nervous system (CNS) and adipose tissue, and which may be used to transduce cells for introduction of genes of interest into the target tissues. Pharmaceutical compositions are also provided that include AAV vectors and a pharmaceutically acceptable excipient, diluent or carrier. | 2021-12-02 |
20210371881 | DEVICES AND METHODS FOR TRANSFECTION - Disclosed herein are methods, assemblies, systems, kits and devices for introducing molecules or compositions into cells or cell-like bodies. An assembly for introducing molecules in a solution into cells or cell-like bodies comprises a rigid container having a first inner diameter or cross-sectional area at a proximal end thereof and inner and outer walls extending between a distal and proximal end, a plunger insertable into the container at the proximal end, and at least one constriction of only the inner wall proximal to the distal end or at least one constriction of the inner and the outer walls proximal to the distal end, wherein the at least one constriction has a second inner diameter or cross-sectional area that is smaller than the container first inner diameter or cross-sectional area and the plunger is axially movable along the container. | 2021-12-02 |
20210371882 | METHOD FOR COUNTERSELECTION IN MICROORGANISMS - The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as | 2021-12-02 |
20210371883 | CRISPR HYBRID DNA/RNA POLYNUCLEOTIDES AND METHODS OF USE - The present disclosure provides DNA-guided CRISPR systems; polynucleotides comprising DNA, RNA and mixtures thereof for use with CRISPR systems; and methods of use involving such polynucleotides and DNA-guided CRISPR systems. | 2021-12-02 |
20210371884 | SYNTHESIS OF ISOPRENOIDS AND DERIVATIVES - This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyloin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways. These precursors can be modified to various isoprenoid products through prenyl transferase, terpene synthase, or terpene cyclases. The production of prenylated aromatic compounds is achieved through prenyl transfer of the hydrocarbon units of isoprenoid precursors to polyketides. | 2021-12-02 |
20210371885 | MUCONIC ACID-PRODUCING TRANSFORMED MICROORGANISM AND USE THEREOF - The objective of the present invention is to provide a microorganism that makes it possible to produce muconic acid from a lignin-derived aromatic compound with sufficient economic efficiency and without depending on the type of lignin, and a method of producing muconic acid using the microorganism. The objective can be achieved by a transformed microorganism wherein the host microorganism is a microorganism of the genus | 2021-12-02 |
20210371886 | PROCESS FOR CONTROLLING A FERMENTATION PROCESS - A process controlling development of at least two predetermined metabolites in a fermented product comprising at least one plant material and/or at least one seaweed material, the process comprising the steps of: (i) Determining the at least 2 predetermined metabolites to be developed in the fermented product; (ii) Based on the predetermined metabolites determined in step (i) selecting at least one plant material and/or the at least one seaweed material; (iii) Based on the predetermined metabolites determined in step (i) selecting at least one fermenting organism; (iv) Mixing the at least one plant material and/or the at least one seaweed material selected in step (ii) with the at least one fermenting organism selected in step (iii) in a fermentation reactor providing a fermentation mixture; (v) Allowing the fermentation mixture to ferment under fermentation conditions favoring development of the at least two predetermined metabolites; whereby the fermented product is provided. | 2021-12-02 |
20210371887 | METHOD AND APPARATUS FOR THE UTILIZATION OF ZERO FIBER AND OTHER SIDE STREAMS - A combined process for several biorefinery products obtained from an Undefined Mixed Culture (UMC) type of reaction it is possible to obtain biochemicals, energy gases, soil improvement etc. from a Multipurpose Biorefinery Unit MPBU). The economically beneficial as well as environmentally sustainable results of the arrangement are demonstrated by the integrated process using two reactor systems with zero fiber for the production of lactate in both the reactors pools | 2021-12-02 |
20210371888 | CONTINUOUS BIODIESEL SYNTHESIS PROCESS BY TRANSESTERIFICATION WITH SUPERCRITICAL METHANOL - A continuous process for the synthesis of biodiesel from microalgae oil by transesterification with supercritical methanol, where the synthesis of biodiesel is carried out in a single transesterification step in a reactor that operates continuously, said process being ideal to be carried out at industrial scale since it can provide a continuous flow of biodiesel. | 2021-12-02 |
20210371889 | Methods And Compositions For Improved Production Of Fatty Acids And Derivatives Thereof - The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR. | 2021-12-02 |
20210371890 | METHOD AND AN APPARATUS FOR AN ENZYMATIC HYDROLYSIS, A LIQUID FRACTION AND A SOLID FRACTION - In a method and an apparatus for an enzymatic hydrolysis in which plant based raw material is hydrolysed by means of enzymes in at least one enzymatic hydrolysis stage. A plant based feed ( | 2021-12-02 |
20210371891 | DE NOVO POLYNUCLEOTIDE SYNTHESIS WITH SUBSTRATE-BOUND POLYMERASE - De novo polynucleotide synthesis is performed with a substrate-bound polymerase. The polymerase is attached to a solid substrate such as a microelectrode array. The polymerase adds nucleotides to growing polynucleotides strands that are also attached to the solid substrate. Spatial control of polymerase activity is achieved by changing the rate of nucleotide polymerization at selected locations on the surface of the solid substrate. The rate of polymerization is changed by inhibiting or promoting activity of the polymerase. In some implementations, activation of electrodes in the microelectrode array changes the rate of nucleotide polymerization. Nucleotides are added to the growing polynucleotide strands at areas where the polymerase is active. By varying the locations where the substrate-bound polymerase is active and the species of nucleotide added, a population of polynucleotides with different, arbitrary sequences is synthesized on the surface of the solid substrate. | 2021-12-02 |
20210371892 | STEVIA REBAUDIANA KAURENOIC ACID HYDROXYLASE VARIANTS FOR HIGH EFFICIENCY PRODUCTION OF REBAUDIOSIDES - Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a | 2021-12-02 |
20210371893 | CELL-FREE PROTEIN SYNTHESIS METHOD - A cell-free protein synthesis method includes the following steps: (i) providing a multi-well plate, the multi-well plate includes a cover plate and a base provided with a plurality of wells. Each well is formed by one or more side walls, a bottom II and an opening, and the cover plate matches the opening; (ii) providing fluid to some of the wells; (iii) adding a biochemical factor and one or more of a template DNA, a template RNA | 2021-12-02 |
20210371894 | METHOD FOR ANALYZING SAMPLES - A method for processing samples is presented, said method useful for, among other uses, analysis of components of a sample including lipids, said method further useful for identification of microorganisms, bulk extraction of lipids, detecting infections and other diseases, and other purposes. | 2021-12-02 |
20210371895 | BACTERIAL RESPONSE - Methods, sample vessels, and instruments are provided for determining antibiotic resistance of a bacterium. | 2021-12-02 |
20210371896 | DEVICES, SYSTEMS, AND METHODS FOR PREPARING A STANDARDIZED INOCULUM FOR ANTIMICROBIAL SUSCEPTIBILITY TESTING - Various apparatus, systems, and methods for measuring a solution characteristic of a sample comprising microorganisms are disclosed. The measured solution characteristic can be used to generate a standardized inoculum. In one embodiment, a sensor apparatus is disclosed comprising a sample container having a chamber lateral wall surrounding a chamber cavity configured receive the sample, a reference sensor fabricated as a container cap and comprising a reference electrode material and, and an active sensor made of a substrate covered in part by an active electrode layer. The active sensor can be coupled to at least part of the chamber lateral wall at a window opening defined along the chamber lateral wall. The solution characteristic can be measured using a reader configured to electrically couple to the sensor apparatus and measure the solution characteristic based on a potential difference between the active sensor and the active sensor. | 2021-12-02 |
20210371897 | METHOD FOR THE DETERMINATION OF SEQUENCE VARIANTS OF POLYPEPTIDES - The invention is directed to a method for determining amino acid sequence mutations in a produced polypeptide, comprising the following steps of a) providing a sample of a produced polypeptide, b) incubating the polypeptide in the sample with a protease, c) performing a two dimensional analysis using reversed phase chromatography coupled with a high resolution mass spectroscopy (FT-ICR/FT-orbitrap) and MS/MS analysis of the amino acid sequence fragments of the peptides, d) data evaluation by comparing the LC-MS data sets obtained for the samples side by side with the data set of a reference sample, by searching for differences in the signal intensities at given retention times and by evaluation of differential signals with respect to amino acid sequence mutations. The reference sample for data evaluation (d) can be either a well characterized standard or one of the samples to be analyzed. | 2021-12-02 |
20210371898 | COMPOSITIONS AND METHODS FOR DETERMINING THE PRESENCE OF ACTIVE LEUKOCYTE CELLS USING AN ELECTROCHEMICAL ASSAY - The present disclosure relates to compositions, methods and test devices for determining the presence of active leukocyte cells, for example, by using novel LE and/or HNE substrates in an electrochemical assay. | 2021-12-02 |
20210371899 | METHOD AND KIT FOR PESTICIDES DETECTION, AND PLASMID, BACULOVIRUS, CELL AND METHOD OF PREPARING THE SAME FOR PESTICIDE DETECTIONS - This disclosure provides a method and a kit for pesticide detection. By expressing acetylcholinesterases on cell surface, rapid pesticide screening, identification and quantification of pesticides or insecticides may be achieved. | 2021-12-02 |
20210371900 | QUANTITATIVE ASSESSMENT FOR CAP EFFICIENCY OF MESSENGER RNA - The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro. In some embodiments, methods according to the present invention comprise providing an mRNA sample containing capped and uncapped mRNA, providing a cap specific binding substance under conditions that permit the formation of a complex between the cap specific binding substance and the capped mRNA, and quantitatively determining the amount of the complex as compared to a control, thereby quantifying mRNA capping efficiency. | 2021-12-02 |
20210371901 | Kits and Methods for Detecting Methylated DNA - The present invention relates to an in vitro method for detecting methylated DNA comprising (a) coating a container with a polypeptide capable of binding methylated DNA; (b) contacting said polypeptide with a sample comprising methylated and/or unmethylated DNA; and (c) detecting the binding of said polypeptide to methylated DNA. In a preferred embodiment, said method further comprises step (d) analyzing the detected methylated DNA by sequencing. Another aspect of the present invention is a kit for detecting methylated DNA according to the methods of the invention comprising (a) a polypeptide capable of binding methylated DNA; (b) a container which can be coated with said polypeptide; (c) means for coating said container; and (d) means for detecting methylated DNA. | 2021-12-02 |
20210371902 | SYSTEMS AND DEVICES FOR INFECTIOUS DISEASE SCREENING | 2021-12-02 |
20210371903 | PCR PRIMER PAIR FOR IDENTIFICATION OF OMMASTREPHES BARTRAMII IN THE NORTH PACIFIC OCEAN BASED ON ENVIRONMENTAL DNA, AND METHOD FOR IDENTIFYING OMMASTREPHES BARTRAMII USING THE SAME - A primer pair for identification of | 2021-12-02 |
20210371904 | Recovering Long-Range Linkage Information From Preserved Samples - The disclosure provides methods to isolate genome or chromosome level structural information from preserved samples. In some cases, samples preserved under conditions where long-range nucleic acid information is believed to be irreparably lost, such as FFPE samples, are treated to recover nucleic acid-protein complexes stabilized as part of the sample preservation process. The complexes are processed so as to recover information regarding which nucleic acids are bound to a common complex, and the information is used to recover genomic structural information. | 2021-12-02 |
20210371905 | SURVEILLANCE METHOD TO SCREEN ASYMPTOMATIC ESSENTIAL WORKERS FOR EXHALATION OF SARS-COV-2 - Disclosed herein is a COVID-19 surveillance method for detecting exhaled virions trapped within used face masks. This is a surveillance and warning system for identifying asymptomatic and pre-symptomatic individuals, particularly essential workers required to wear masks while at work. This can include healthcare workers, first responders, nursing home personnel, postal workers, or employees at meat packing and other production facilities. A piece of filter paper can be added to the inside of a standard face mask, which can be removed at the end of a shift. Mask inserts from a group of employees can be pooled and tested using standard RT-PCR for virions collected during normal exhalation over the time the mask is worn. As envisioned, if the group test is positive, additional follow-up or contact tracing could be initiated to identify the individual or individuals requiring treatment or quarantine. | 2021-12-02 |
20210371906 | DETECTION OF HYDROXYMETHYLCYTOSINE BASES - Methodologies for labeling the epigenetic modification 5-hydroxymethyl-cytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed. | 2021-12-02 |
20210371907 | USING CELL-FREE DNA FRAGMENT SIZE TO DETERMINE COPY NUMBER VARIATIONS - Disclosed are methods for determining copy number variation (CNV) associated with a variety of medical conditions. In some embodiments, methods are provided for determining copy number variation (CNV) of fetuses using maternal samples comprising maternal and fetal cell free DNA. In some embodiments, methods are provided for determining CNVs associated with a variety of medical conditions. Some embodiments disclosed herein provide methods to improve the sensitivity and/or specificity of sequence data analysis by deriving a fragment size parameter, such as a size-weighted coverage or a fraction of fragments in a size range. In some embodiments, the fragment size parameter is adjusted to remove within-sample GC-content bias. In some embodiments, removal of within-sample GC-content bias is based on sequence data corrected for systematic variation common across unaffected training samples. Also disclosed are systems and computer program products for evaluation of CNV of sequences of interest. | 2021-12-02 |
20210371908 | COMPARING COPIES OF POLYNUCLEOTIDES WITH DIFFERENT FEATURES - Provided is a method including making copies of two or more populations of polynucleotides including identifier sequences, wherein the copies are attached to a substrate, hybridizing oligonucleotides to the identifier sequences, and comparing an amount of oligonucleotides hybridized to the copies of the two or more populations of polynucleotides, wherein at least one feature differs between the two or more populations of polynucleotides or between the making of the copies of the two or more populations of polynucleotides attached to the substrate. | 2021-12-02 |
20210371909 | OLIGONUCLEOTIDES AND BEADS FOR 5 PRIME GENE EXPRESSION ASSAY - Disclosed herein include systems, methods, compositions, and kits for 5′-based gene expression profiling. Some embodiments provide synthetic particles (e.g., beads) associated with a first plurality of oligonucleotide barcodes and a second plurality of oligonucleotide barcodes. In some embodiments, nucleic acid targets (e.g., mRNAs) are initially barcoded on the 3′ end with the first plurality of oligonucleotide barcodes and subsequently barcoded on the 5′ end following a template switching reaction and intermolecular hybridization with the first plurality of oligonucleotide barcodes and extension. Immune repertoire profiling methods are also provided in some embodiments. | 2021-12-02 |
20210371910 | DETECTION OF DNA HYDROXYMETHYLATION - Reagents and methods for analysis of DNA hydroxymethylation are provided. Methods comprise modification of hydroxymethylated cytosine residues with a bulky moiety to protect hydroxymethylated positions from cleavage with a DNA endonuclease. For example, methods may comprise contacting DNA with a glucosyltransferase to glucosylate hydroxymethylated DNA positions and digesting the DNA with a DNA endonuclease to cleave DNA in positions lacking hydroxymethylation. Reagents and kits for hydroxymethylated DNA analysis are also provided. | 2021-12-02 |
20210371911 | COMPETITIVE COMPOSITIONS OF NUCLEIC ACID MOLECULES FOR ENRICHMENT OF RARE-ALLELE-BEARING SPECIES - The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies. | 2021-12-02 |
20210371912 | SYSTEMS AND METHODS TO DETECT RARE MUTATIONS AND COPY NUMBER VARIATION - The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease. | 2021-12-02 |
20210371913 | METHOD FOR DETECTING CHROMOSOMAL ABNORMALITIES - The invention relates to a method for identifying chromosomal abnormalities, particularly structural and/or numerical chromosomal abnormalities, and preferably structural chromosomal abnormalities, using insitu hybridization by detecting chromosomes and/or DNA regions in a biological sample, preferably in one or more cell(s) and/or in one or more cell nuclei. | 2021-12-02 |
20210371914 | METHODS AND COMPOSITIONS FOR IDENTIFYING OR QUANTIFYING TARGETS IN A BIOLOGICAL SAMPLE - Compositions, kits and methods are described that comprise one or more constructs, each construct comprising a ligand attached or conjugated to a polymer construct, e.g., an oligonucleotide sequence, by a linker, each ligand binding specifically to a single target located in or on the surface of a cell. The polymer construct comprises a) an Amplification Handle; b) a Barcode that specifically identifies a single ligand; c) an optional Unique Molecular Identifier that is positioned adjacent to the Barcode on its 5′ or 3′ end; and d) an Anchor for hybridizing to a complementary sequence, e.g., for generation of a double-stranded oligonucleotide. These compositions are used in methods, including high throughput methods, for detecting one or more targets or epitopes in a biological sample. These compositions are also used in a high throughput method for characterizing a cell by simultaneous detection of one or more epitopes located in or on the cell and its transcriptome. | 2021-12-02 |
20210371915 | METHOD FOR REAL TIME MONITORING OF NUCLEIC ACID AMPLICONS MEDIATED BY LOOP OLIGONUCLEOTIDE PROBES - The subject invention pertains to the rapid amplification and real-time monitoring of nucleic acid sequences at a constant temperature. Specifically, fluorescent or electroactive-labeled loop probes and primers are designed to be specific to identified regions of a target nucleic acid sequences and subsequently amplify and permit the identification of the presence of the target sequence. In this method, a DNA polymerase with no 5′ to 3′ exonuclease activity is added to extend the primers and probes, while a nicking endonuclease is added to specifically identify the amplified nucleic acid product and cleave the label from the loop probe-extended DNA duplex. | 2021-12-02 |
20210371916 | COMPUTING DEVICE, STORAGE MEDIUM, AND METHOD FOR MANAGING SEQUENCING PROGRESS - A method of managing sequencing progress includes obtaining a plurality of samples and controlling a gene sequencing computing device to execute gene sequencing on the plurality of samples. Once a sequencing result is obtained by sending a query instruction to the gene sequencing computing device, sequencing information of the plurality of samples is displayed when a sequencing progress of the plurality of samples is determined to be meeting the preset condition according to the sequencing result. | 2021-12-02 |
20210371917 | TEMPERATURE CONTROL FOR ANALYSIS OF NUCLEIC ACIDS AND OTHER ANALYTES - Provided herein and methods and apparatuses for sequencing nucleic acids. For example, provided is an analytical detection apparatus, including (a) a stage configured to support a flow cell; (b) a detector configured to observe a detection channel of the flow cell when the flow cell is supported by the stage; (c) a plurality of fluid delivery channels, wherein each of the fluid delivery channels fluidically connects a reservoir to the detection channel of the flow cell; and (d) a first heater configured to heat the plurality of fluid delivery channels. | 2021-12-02 |
20210371918 | NUCLEIC ACID CHARACTERISTICS AS GUIDES FOR SEQUENCE ASSEMBLY - Methods and compositions for the de novo generation of scaffold information, linkage information and genome information for unknown organisms in heterogeneous metagenomic samples or samples obtained from multiple individuals are disclosed. Methods of the disclosure use a combination of restriction enzymes that have different sensitivities to specific base modifications to generate Chicago libraries. Practice of the methods allows de novo sequencing of entire genomes of uncultured or unidentified organisms in heterogeneous samples, or the determination of linkage information for nucleic acid molecules in samples comprising nucleic acids obtained from multiple individuals. | 2021-12-02 |
20210371919 | NANOWIRE-BASED SYSTEM FOR ANALYSIS OF NUCLEIC ACIDS - A method for sequencing a nucleic acid template includes forming a nanowire assembly including a semiconductor nanowire and a probe covalently bound to the semiconductor nanowire; contacting the nanowire assembly with a template nucleic acid; contacting the nucleic acid duplexes with an extension nucleic acid, the extension nucleic acid joined to the probe; disrupting the nucleic acid duplexes; and measuring an electrical characteristic of a nanowire assembly of the set of nanowire assemblies. | 2021-12-02 |
20210371920 | METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING - Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. | 2021-12-02 |
20210371921 | METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING - Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. | 2021-12-02 |
20210371922 | METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING - Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. | 2021-12-02 |
20210371923 | METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING - Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. | 2021-12-02 |
20210371924 | METHODS OF LOWERING THE ERROR RATE OF MASSIVELY PARALLEL DNA SEQUENCING USING DUPLEX CONSENSUS SEQUENCING - Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands. | 2021-12-02 |
20210371925 | MOLECULAR SIGNATURES OF THREE SUB-POPULATIONS OF DERMAL FIBROBLASTS AND DERMAL EQUIVALENT COMPRISING ONE OF THESE SUB-POPULATIONS - The object of this invention is a method of in vitro identification of a dermal fibroblast as being a papillary fibroblast, a reticular fibroblast or a dermal-hypodermal junction fibroblast (FJDH), comprising a step of measuring the level of an expression product of at least one gene selected from the group consisting in the UCP2 and FGF9, and optionally the COL11 A1 and ACAN genes, and the level of an expression product of the KLF9 gene. | 2021-12-02 |
20210371926 | CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS - The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect both DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences, and includes detection by colorimetric and/or fluorescence shifts. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA. | 2021-12-02 |
20210371927 | BIOMARKERS FOR DIABETES THERAPY - The invention relates to an in-vitro method for identifying a diabetic patient as responder or non-responder to a treatment of Proinsulin, Interleukin 10 and anti-CD3, based on the expression level of at least 1 microRNA, selected from the group consisting of miR-365, miR-34a, miR-193b and miR-125a, in a sample from the diabetic patient prior to said treatment. | 2021-12-02 |
20210371928 | METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST - This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test. | 2021-12-02 |
20210371929 | METHOD FOR PREDICTION OF RESPONSE TO DISEASE THERAPY - The present invention relates to a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, comprising the use of a biomarker. Further, the present invention relates to a combination of biomarkers for use in a method for prediction of response to disease therapy, in particular to tissue regeneration, preferably to cardiovascular regeneration, a computer device to perform a method according to the present invention and a device adapted for carrying out the inventive method. | 2021-12-02 |
20210371930 | Solute Carrier Family 26 Member 5 (SLC26A5) Variants And Uses Thereof - The present disclosure provides methods of treating a subject having hearing loss, methods of identifying a subject having an increased risk of developing hearing loss, and methods of detecting Solute Carrier Family 26 Member 5 (SLC26A5) variant nucleic acid molecules and variant polypeptides. | 2021-12-02 |
20210371931 | VARIANTS OF TNFSF15 AND DCR3 ASSOCIATED WITH CROHN'S DISEASE - Described herein are methods and compositions related to the discovery of associations in TNFSF15 15 and DcR3 genetic loci across in Caucasian, Puerto Rican, and Korean Crohn's Disease, as demonstrated via trans-ethnic fine mapping. The present invention provides methods of quantifying risk and diagnosing susceptibility to Crohn's disease in a subject by determining the presence of one or more risk variants are at the TNF SF15 (or TL1A) and/or DcR3 genetic loci. | 2021-12-02 |
20210371932 | METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING MICROENVIRONMENT GENE SIGNATURES FROM THE CSF OF METASTASIS PATIENTS - The subject matter disclosed herein is generally directed to detecting and modulating novel gene signatures for the treatment and prognosis of cancer. The gene signatures can be detected in samples obtained from the extracellular fluid of a subject suffering from cancer. The novel gene signatures can be used to predict and monitor responses to immunotherapy in cancer and can be targeted therapeutically. The immunotherapy can be immune checkpoint inhibition therapy. | 2021-12-02 |
20210371933 | COMPOSITIONS FOR DETECTING MUTANT ANAPLASTIC LYMPHOMA KINASE IN LUNG CANCER - Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 2021-12-02 |
20210371934 | TUMOR GRADING AND CANCER PROGNOSIS - The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that are expressed in correlation with tumor grade. The levels of gene expression are disclosed as a molecular index for determining tumor grade in a patient and predicting clinical outcome, and so prognosis, for the patient. The molecular grading of cancer may optionally be used in combination with a second molecular index for diagnosing cancer and its prognosis. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer. For diagnosis or prognosis, the disclosure further includes methods for determining or selecting the treatment of cancer based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis. | 2021-12-02 |
20210371935 | IDENTIFICATION OF PDE3 MODULATOR RESPONSIVE CANCERS - The present disclosure features methods for identifying pateints having a hyperproliferative disease, disorder, or condition responsive to phosphodiesterase 3 (PDE3) and schlafen family member 12 (SLFN12) complex formation. The hyperproliferative disease, disorder, or condition may be cancer in a patient including glioblastoma, melanoma, ovarian cancer, cervical cancer, sarcoma, or hematopoietic cancers, such as acute myeloid leukemia. Those responsive diseases, disorders, or conditions may be identified using the biomarker AIP and/or TRRAP in combination with those biomarkers pertinent to phosphodieseterase 3 and schlafen family member 12 complexes which may be formed by PDE3 modulation with certain active compounds. Expression of combinations of these biomarkers have been shown to correlate with active compound (e.g., PDE3 modulator, PDE3A modulator, PDE3B modulator) sensitivity. | 2021-12-02 |
20210371936 | PREDICTIVE METHODS IN BREAST CANCER - The present invention relates to methods of predicting the probability of an Oncotype DX® low risk recurrence score (RS) result (RS≤25) for a breast cancer patient, to methods for selecting a breast cancer treatment, and to methods of treatment of breast cancer. It also relates to the use of a kit in these methods. | 2021-12-02 |
20210371937 | METHOD FOR IDENTIFYING HIGH-RISK AML PATIENTS - There is described herein an assay comprising, for each of DNMT3B, ZBTB46, NYNRIN, ARHGAP22, LAPTM4B, MMRN1, DPYSL3, KIAA0125, CDK6, CPXM1, SOCS2, SMIM24, EMP1, NGFRAP1, CD34, AKR1C3, GPR56, a pair of probes complementary and hybridizable thereto on an array, optionally with a set of reference genes. | 2021-12-02 |
20210371938 | MICROBIOME BASED SYSTEMS, APPARATUS AND METHODS FOR MONITORING AND CONTROLLING INDUSTRIAL PROCESSES AND SYSTEMS - There are provided methods, systems and processes for the utilization of microbial and related genetic information for use in industrial settings, such as the exploration, determination, and recovery of natural resources, minerals, and energy sources, the monitoring and analysis of processes, activities, and materials transmission. | 2021-12-02 |
20210371939 | MECHANICAL LYSIS AND EXPOSURE BY HOMOGENIZATION FOR DIRECT VIRAL NUCLEIC ACID AMPLIFICATION - Methods and systems of analyzing a biological sample to detect the presence of a virus are disclosed, that include mechanically homogenizing the biological sample, wherein the biological sample is unprocessed, to lyse the unprocessed biological sample to produce a homogenized sample; amplifying the viral nucleic acids in the homogenized sample, where such amplification occurs without any isolation, separation, purification, or extraction of the viral nucleic acids in the homogenized sample; and analyzing the amplified viral nucleic acids to detect the presence of the virus. | 2021-12-02 |
20210371940 | PROCESS FOR IDENTIFYING AND QUANTIFYING NUCLEIC ACID SEQUENCES FROM LIVE MICROORGANISMS - Described are methods for isolating, amplifying and analyzing nucleic acids from live cells in mixed cultures suspected of containing living cells, dead cells, and/or free nucleic acids released extracellularly from dead or dying cells. Also provided are processed test samples and kits for preparation thereof. | 2021-12-02 |
20210371941 | SYSTEMS AND METHODS FOR DETECTION OF LOW-COPY NUMBER NUCLEIC ACIDS - Disclosed are compositions, methods, and systems for genetic identification and detection of low-copy number nucleic acids, and provides method, compositions, and kits useful for this purpose. The methods of the invention can be used to detect in a given sample the presence of low-copy number of nucleic acids (e.g., DNA or RNA) of various microorganisms, including SARS-COV-2. | 2021-12-02 |
20210371942 | EVAPORATOR SYSTEM, KIT FOR ASSEMBLING THE SAME, AND CORRESPONDING METHODS OF ASSEMBLING, OPERATING AND USE ASSOCIATED THERETO - Evaporator system used for the production of maple syrup. The evaporator system includes at least one receptacle, a combustion chamber, an evacuation port and an air supply system. The evaporator system also includes a door assembly being configured for removably mounting onto a corresponding support frame of the evaporator system, and being operable between an opened configuration for allowing access to the combustion chamber and to be able to selectively feed biomass into the combustion chamber via the inlet thereof, and a closed configuration for preventing access to and closing off the inlet of the combustion chamber, the door assembly being provided with at least one aeration passage extending between an outer portion of the door assembly and an inner portion therefor, for providing a supply of secondary air to the combustion chamber via said at least one aeration passage of the door assembly when operated in the closed configuration. | 2021-12-02 |
20210371943 | COOLING BOX FOR A SHAFT FURNACE - A cooling box for a metallurgical furnace including an elongated hollow body extending from a front end, to an opposite rear end, the rear end being, in use, connected to a wall of the furnace; the body includes an inner chamber having a cooling circuit configured to receive a flow of coolant fluid therein between at least one inlet and at least one outlet; the cooling box further including at least one partition plate fitted in the inner chamber through a form-fit connection to form the cooling circuit. | 2021-12-02 |
20210371944 | HIGH-CARBON BEARING STEEL AND PREPARATION METHOD THEREOF - The invention relates to the technical field of microstructure refinement and homogenization of bearing steel, and specifically relates to a high-carbon bearing steel and a method of preparing same. The high-carbon bearing steel of the invention has the following chemical composition: C: 0.80˜1.20 wt %, Cr: 0.40˜2.0 wt %, Mn: 0.15˜0.75 wt %, Si: 0.15˜0.75 wt %, Nb: 0˜0.20 wt %, Mo: 0˜0.20 wt %, V: 0˜0.20 wt %, P≤0.015 wt %, S≤0.01 wt %, the remaining is Fe and unavoidable impurities; the contents of Nb, Mo and V are not 0 at the same time. According to the invention, microalloying elements such as Nb, Mo and V, in combination with other elements, are added into the high-carbon bearing steel to effectively refine the bearing steel matrix and promote the precipitation of a large amount of nano-carbides, thereby enhancing the contact fatigue life of the high-carbon bearing steel. | 2021-12-02 |
20210371945 | HIGH FRACTURE TOUGHNESS, HIGH STRENGTH, PRECIPITATION HARDENABLE STAINLESS STEEL - A precipitation hardenable, martensitic stainless steel is disclosed. The alloy has the following broad composition in weight percent. | 2021-12-02 |
20210371946 | METHOD FOR PRODUCING A RAW WIRE FROM A FIRST METAL STRIP AND AT LEAST ONE FURTHER METAL STRIP BY ROLL PROFILING - A method for producing a feedstock wire is produced from a first metal strip and at least one further metal strip by roll forming, wherein in particular the first metal strip and the at least one further metal strip are made of differing metals, preferably of differing meals having differing yield points, wherein a jacket, which in the final shape completely surrounds the at least one further metal strip in the circumferential direction, is formed from the first metal strip in a plurality of passes by roll forming using a plurality of roll stands, and wherein, first, exclusively only the first metal strip is formed to a preliminary shape in a plurality of passes using a first group of roll stands and, thereafter, the first metal strip and the at least one further metal strip are jointly formed to the final shape in a second group of roll stands. | 2021-12-02 |
20210371947 | ALLOYED STEEL AND QUENCHED AND TEMPERED STEEL - The invention relates to steel with a specific composition of the following elements: 0.25%≤C≤0.35%, 0.80%≤Cr≤1.50%, 0.50%≤Ni≤1.50%, 0.0010%≤B≤0.0050%, 0.010%≤Ti≤0.060%, 0.40%≤Mn≤1.00% and 0.003%≤N≤0.0150%, whereby after being subjected to a quench and tempering treatment, the characteristics required by the ISO 898-1 standard for class 10.9 and class 12.9 bolts, screws and studs are achieved, while at the same time achieving high fatigue strength values. The use of this steel allows achieving the mentioned characteristics in large-sized parts or elements (up to a diameter of 75 mm), considerably reducing the alloying costs compared with the steels used today. | 2021-12-02 |
20210371948 | NON-ORIENTED ELECTRICAL STEEL SHEET AND METHOD FOR PRODUCING SAME, AND MOTOR CORE AND METHOD FOR PRODUCING SAME - A non-oriented electrical steel sheet with an average magnetostriction λ | 2021-12-02 |
20210371949 | METHOD AND APPARATUS FOR POST WELD HEAT TREATMENT OF ALUMINIUM ALLOY COMPONENTS, AND A WELDED ALUMINIUM COMPONENT TREATED ACCORDING TO THE METHOD - A method and an apparatus for Post Weld Heat Treatment (PWHT) of a welded aluminium alloy component and a welded aluminium alloy component treated according to the method. The welded component has initially heat affected zones with reduced load bearing capacity. The method provides that the heat affected zones are located, applying a heat source at least at one first location of said heat affected zones, where the heat source generates a temperature above T | 2021-12-02 |
20210371950 | LASER SHOCK AND SUPERSONIC VIBRATION EXTRUSION CO-STRENGTHENING DEVICE AND METHOD - A laser shock and supersonic vibration extrusion co-strengthening device and method. The device comprises a laser assembly, a vibration assembly, a hydraulic assembly and a connecting assembly. The method strengthens a hole ( | 2021-12-02 |
20210371951 | SEALING SYSTEM FOR A MACHINE FOR THERMAL TREATMENT OF BULK MATERIAL - The disclosure relates to a machine for thermal treatment of bulk material, comprising: a stationary furnace which presents a support structure, and a plurality of pallet cars traveling through the furnace, said plurality of pallet cars together defining, at a lateral side thereof, a common engagement surface which extends through the furnace, wherein a gap is defined between the support structure of the furnace and the common engagement surface, said gap having a gap length, the machine further comprising: a sealing system comprising a series of leaf members which are partially overlapping, wherein each leaf member of the series of leaf members is connected to the support structure at a first end thereof, and self-biased into engagement with the engagement surface at a second, opposite, end thereof such that the series of leaf members, together, cover the gap over at least part of the gap length. | 2021-12-02 |
20210371952 | METHOD FOR DISSOLVING METALS BY PHOTOCATALYSIS - The present invention relates to a method for dissolving metals by photocatalysis. A metal-containing material to be dissolved is dispersed in a mixed solution of photocatalyst-containing cyanide and organic chloride; then, a photocatalyst is added; next, an oxygen-containing gas or a substance which is capable of generating oxygen is introduced; and irradiation is applied for a period of time to dissolve metals. Compared with the prior method, the present invention is advantageous in moderate reaction condition, energy conservation, environmental protection, low cost, and convenient operation, and is suitable for mass industrial treatment on metal dissolution. | 2021-12-02 |
20210371953 | METHOD FOR THE TREATMENT OF IRON-CONTAINING SLUDGE - A method for the treatment of sludge containing iron, the method including a leaching step wherein the sludge containing iron is mixed with an acid and an oxidation agent so as to create an oxidized leachate, and a step of precipitation of iron wherein the oxidized leachate is mixed with a neutralizing agent so as to create a mixture composed of a solid part including precipitated iron and of a liquid part, the neutralizing agent including at least 30% in weight of dust recovered from a bag filter treatment of ironmaking, steelmaking, coke making or sintering gas. | 2021-12-02 |
20210371954 | METHOD FOR OPTIMIZING LIQUID INJECTION PROCESS OF IONIC RARE EARTH ORE - The present disclosure provides a method for optimizing a liquid injection process of ionic rare earth ore, including the following steps of: 1) testing the hydraulic properties of an ore body; 2) determining the diffusion degree of the ore body; 3) determining the spatial distribution of the rare earth grade and the impurity grade of the ore body prior to leaching; 4) determining model parameters of competitive exchange of rare earth ions and impurity ions with ammonium ions; 5) obtaining distribution of rare earth ion concentration within the ore body after completion of leaching; 6) obtaining a profile plot of a rare earth leaching rate as a function of the concentration and dosage of an injected leaching agent; and 7) determining a minimum leaching agent dosage to achieve a target leaching rate according to the profile plot, and then determining the ammonium sulfate concentration according to the minimum leaching agent dosage. | 2021-12-02 |
20210371955 | METHOD FOR MANUFACTURING PRECIOUS METAL ALLOYS AND PRECIOUS METAL ALLOYS THUS OBTAINED - A method for manufacturing a part by alloying a precious metal with boron, wherein: a quantity of precious metal reduced to powder form is provided; a quantity of a nano-structured micrometric boron powder is provided; the precious metal powder is mixed with the nano-structured micrometric boron powder to obtain a mixture; the mixture is compacted by applying a uniaxial pressure; the mixture is subjected to a spark plasma sintering or flash sintering treatment, or to a hot isostatic pressing (HIP) treatment, to obtain an ingot of a precious metal/boron alloy, and the ingot is machined to obtain the part, or the ingot is reduced to powder form by a micronisation treatment and the powder is treated to obtain the part. Additionally, a gold/boron alloy. | 2021-12-02 |
20210371956 | ALLOYS AND SEMI-FINISHED PRODUCTS AND PRODUCTS CONTAINING SAME - Described includes an alloy consisting of at least 33 wt. % to at most 75.5 wt. % gold, at least 1.5 wt. % to at most 45 wt. % silver, at least 8 wt. % to at most 45 wt. % copper, the remainder being zinc. The invention also relates to a semi-finished product made from such an alloy, a piece of jewelry having at least one such semi-finished product, and a method for producing such a semi-finished product. | 2021-12-02 |
20210371957 | TITANIUM COPPER FOIL, EXTENDED COPPER ARTICLE, ELECTRONIC DEVICE COMPONENT, AND AUTO-FOCUS CAMERA MODULE - Provided is a titanium copper foil which has required high strength when used as a spring, has an improved etching property, and has decreased settling, and which can be suitably used as a conductive spring material for use in electronic device parts such as autofocus camera modules. The titanium copper foil according to the present invention contains from 1.5 to 5.0% by mass of Ti, the balance being Cu and inevitable impurities, wherein in a Ti concentration curve obtained by analyzing a cross section parallel to a rolling direction along a thickness direction by STEM-EDX, a lower concentration Ti layer having a Ti concentration less than an average value of Ti concentrations in the Ti concentration curve and a higher concentration Ti layer having a Ti concentration equal to or higher than the average value of the Ti concentrations in the Ti concentration curve are alternately present in a thickness direction, and wherein the titanium copper foil satisfies 1.0% by mass≤H | 2021-12-02 |
20210371958 | Ni-BASED ALLOY, AND Ni-BASED ALLOY PRODUCT AND METHODS FOR PRODUCING THE SAME - The present invention relates to an Ni-based alloy which is excellent in terms of wear resistance and high-temperature corrosion resistance and which includes 0.3≤C≤1.0 mass %, 36.0≤Cr≤50.0 mass %, and 3.0≤Al≤7.0 mass %, with the balance being Ni and unavoidable impurities, and relates to an Ni-based alloy product made of the Ni-based alloy according to the present invention, and methods for producing the Ni-based alloy product. | 2021-12-02 |
20210371959 | COBALT-TUNGSTEN ALLOY AND METHOD OF FABRICATING THE SAME - Disclosed are a cobalt-tungsten alloy and a method of fabricating the same. More particularly, cobalt-tungsten alloy nanowires according to an embodiment are formed using an electroplating method, a grain structure of the cobalt-tungsten alloy nanowires is controlled according to the content of tungsten, and the electrical resistivity of the cobalt-tungsten alloy nanowires can be reduced through annealing. | 2021-12-02 |
20210371960 | ALUMINUM ALLOY THICK PLATE - An aluminum alloy thick plate is formed of an aluminum alloy including Mg of 2.0 to 5.0 mass %, and has a plate thickness of 300 to 400 mm. A is 700 pieces/cm | 2021-12-02 |
20210371961 | STEEL MATERIAL SUITABLE FOR USE IN SOUR ENVIRONMENT - The steel material according to the present disclosure has a chemical composition consisting of, in mass %, C: 0.10 to 0.60%, Si: 0.05 to 1.00%, Mn: 0.05 to 1.00%, P: 0.025% or less, S: 0.0100% or less, Al: 0.005 to 0.100%, Cr: 0.20 to 1.50%, Mo: 0.25 to 1.50%, V: 0.01 to 0.60%, Ti: 0.002 to 0.050%, B: 0.0001 to 0.0050%, N: 0.0020 to 0.0100%, and O: 0.0100% or less, with the balance being Fe and impurities. A dislocation density ρ is 3.5×10 | 2021-12-02 |
20210371962 | HIGH-STRENGTH FERRITIC STAINLESS STEEL FOR CLAMP AND METHOD FOR MANUFACTURING SAME - A high-strength ferritic stainless steel for clamp includes, in percent (%) by weight of the entire composition, C: 0.04 to 0.1%, Si: 0.2 to 0.6%, Mn: 0.01 to 1.5%, Cr: 14.0 to 18.0%, Al: 0.005 to 0.2%, V: 0.005 to 0.2%, N: 0.02 to 0.1%, the remainder of iron (Fe) and other inevitable impurities, and satisfies following formulas (1) and (2), and the number of precipitates with an average diameter of 0.5 μm or less is 2.5×10 | 2021-12-02 |
20210371963 | METHOD FOR PREPARING A NICKEL-BASED ALLOY - In a method for preparing a nickel-based alloy, an electrode is produced by VIM, VOF or VLF, heat-treated in a furnace between 500 and 1300° C. for 10 to 336 hours to reduce stresses and aging, the heat-treatment being conducted for at least 10 hours and at most 48 hours at 1000° C. to 1300° C., and cooled to between room temperature and less than 900° C., then remelted using ESR at 3.0 to 10 kg/minute to form an ESR block which is cooled to between room temperature and less than 900° C., and remelted again using VAR at 3.0 to 10 kg/minute and a remelting rate fluctuation range of less than 15%, preferably 10%, ideally 5%; the remelted VAR block is heat-treated between 500 and 1250° C. for 10 to 336 hours, then shaped into the desired product shape and dimension by hot or cold forming. | 2021-12-02 |
20210371964 | POWDER FEEDING DEVICE, THERMAL SPRAYING APPARATUS, POWDER FEEDING METHOD, AND THERMAL SPRAYING METHOD - A powder feeder according to one aspect of the present disclosure is a powder feeding device that feeds powder from a feeder to a nozzle. The powder feeding device includes a cartridge configured to store the powder in an airtight condition, and includes the feeder. The cartridge includes a port from which the powder is stored and withdrawn, and an open/close valve for opening and closing the port. The feeder includes a connection portion to which the cartridge is removably connected, a supply port configured to supply the powder in the cartridge connected to the connection portion into the feeder, and an opening/closing valve for opening and closing the supply port. The feeder is configured to insert the powder supplied from the supply port to the feeder into the nozzle, and the cartridge and the feeder are configured to form an enclosed space between the port and the supply port in response to the cartridge being connected to the connection portion. | 2021-12-02 |
20210371965 | Thermal Spray Metal Coating for Coiled Sucker Rods - The present disclosure relates to a method for coating a coiled sucker rod, the method comprising: (a) transferring the coiled sucker rod from a first reel to a thermal spray metal gun system with a conveyance system; and (b) applying a thermal spray metal coating on the coiled sucker rod with a thermal spray metal gun system to form a thermal spray metal coated coiled sucker rod. | 2021-12-02 |
20210371966 | Mask, Mask Device and Mask Design Method - The present disclosure relates to a mask, a mask device and a mask design method. The mask includes: a pattern area, wherein the pattern area includes a plurality of openings, among which adjacent openings are spaced apart by a first rib, and at least one of the plurality of openings has a non-straight side, two first straight sides intersecting with the non-straight side, and a second straight side opposite to the non-straight side and intersecting with the first straight sides; and a second rib located at an edge of the pattern area, wherein the second rib is provided with a cutout for compensating for stretch deformation of the non-straight side, extending lines of the two first straight sides extending toward the second rib along a first direction intersect with the second rib to obtain a first area, and the cutout is located at least within the first area. | 2021-12-02 |
20210371967 | SELECTIVE DEPOSITION OF METALLIC LAYERS - A method is described for selectively depositing a metallic layer ( | 2021-12-02 |