49th week of 2015 patent applcation highlights part 29 |
Patent application number | Title | Published |
20150344914 | PROCESSING BIOMASS - Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation. | 2015-12-03 |
20150344915 | PROCESS AND APPARATUS FOR PRODUSING CHEMICAL PRODUCT - A process for producing a chemical product comprises a first fermentation step wherein fermentation is conducted by supplying a starting material compound and oxygen to a microorganism-containing liquid, to obtain a first fermentation broth containing a chemical product formed by the fermentation, a second fermentation step wherein the first fermentation broth is taken out and used as a second fermentation broth, and fermentation is conducted by supplying oxygen without supplying a starting material compound, so that the concentration of the starting material compound in the second fermentation broth is adjusted to be a concentration (Y) lower than a concentration (X) of the starting material compound in the first fermentation broth, and a separation step wherein the second fermentation broth is separated to obtain a separated liquid containing the chemical product. | 2015-12-03 |
20150344916 | METHOD FOR PRODUCING 3-HYDROXYPROPIONIC ACID AND OTHER PRODUCTS - This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes 3-hydroxypropionic acid. | 2015-12-03 |
20150344917 | Microbial Oils with Lowered Pour Points, Dielectric Fluids Produced Therefrom, and Related Methods - Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids. | 2015-12-03 |
20150344918 | COMPOSITIONS AND METHODS FOR MAKING AND MODIFYING OILS - The invention provides novel methods for making or modifying oils, e.g., plant animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, linolenic oils, low palmitic oils, low stearic oils or oils low in a combination thereof. | 2015-12-03 |
20150344919 | PROCESS FOR THE PREPARATION OF PREGABALIN - The present invention provides an improved process for the preparation of a compound of formula (I), which comprises the steps of: formula (I), (a) reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) optionally in presence of salts of weak acid and weak base or weak base in a suitable solvent to get 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV); (b) reacting 2-cyano-5-methyl-hex-2-enoic acid alkyl ester of formula (IV) with a suitable cyanide source in water or in an organic solvent or mixture thereof to get 2-isobutylsuccinonitrile of formula (V); (c) obtaining optionally 2-isobutylsuccinonitrile of formula (V) by reacting isovaleraldehyde of formula (II) and alkyl cyanoacetate of formula (III) in presence of suitable cyanide source in water or in an organic solvent or mixture thereof in single step; (d) converting 2-isobutylsuccinonitrile of formula pa (V) to racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) with a genetically modified nitrilase enzyme (Nit pt 9N_56_2) in water or optionally with an organic co-solvent at appropriate pH and temperature; (e) converting racemic 3-cyano-5-methyl-hexanoic acid or salt thereof of formula (VI) to racemic alkyl 3-cyano-5-methyl-hexanoate of formula (VII) by treatment with alcohol (R3OH) and acidic catalyst or alkyl halide (R3X) in presence of a base in a suitable solvent or a mixture of solvents thereof; (f) obtaining (S)-alkyl 3-cyano-5-methyl-hexanoate of formula (VIII) and (R)-3-cyano-5-methyl-hexanoic acid or salt thereof of formula (X) by enzymatic enantioselective hydrolysis in water or organic solvent or a mixture thereof from racemic alkyl 3-cyano-5-methyl-hexanoate of formula (VII); (g) obtaining optionally the compound of formula (VII) by racemizing unwanted (R)-3-cyano-5-methyl-hexanoic acid or salt thereof of formula (X) or substantially enriched (R)-3-cyano-5-methyl-hexanoic acid salt thereof of formula (X) in presence of a base in organic solvent or a mixture thereof; (h) converting (S)-alkyl 3-cyano-5-methyl-hexanoate of formula (VIII) to pregabalin of formula (I) by hydrolyzing ester group with suitable alkali or alkaline earth metal base followed by hydrogenation optionally in one pot in a solvent selected from water or other organic solvents or a mixture thereof in presence of a suitable hydrogenation catalyst. | 2015-12-03 |
20150344920 | Anthocyanins with Specific Properties - The present disclosure provides methods for identifying anthocyanins with improved stability, color, or hue using a screening method, and producing anthocyanins with improved stability, color, or hue in, for example, host cells comprising one or more heterologous glycosyltransferase nucleic acid molecules and one or more heterologous acyltransferase nucleic acid molecules. | 2015-12-03 |
20150344921 | ADVANCED AUGER AND FILTRATION SYSTEM FOR THE SACCHARIFICATION OF BIOMASS - The present disclosure provides methods and systems for generating sugars from biomass. The methods and systems provide increased yields of carbohydrates and fermentable sugars by combining enzyme recycling with removal of saccharification enzyme inhibitors and increased solids loading. | 2015-12-03 |
20150344922 | COMPOSITIONS AND METHODS OF USE - The present compositions and methods relate to a beta-mannanase from | 2015-12-03 |
20150344923 | COMPOSITIONS AND METHODS OF USE - The present compositions and methods relate to a beta-mannanase from | 2015-12-03 |
20150344924 | POLYMER ENHANCEMENT OF ENZYMATIC ACTIVITY - Provided herein are methods for enhancing enzymatic activity using certain polymers that may be optionally attached to an enzyme. The polymers may be thermally-responsive polymers, including poly N-isopropylacrylamide or poly N-isopropylmethacrylamide. The polymer may also be a copolymer with at least two different monomer residues. The monomer residues may have a structure of formula (I): | 2015-12-03 |
20150344925 | KETOSE 3-EPIMERASE PRODUCED BY ARTHROBACTER GLOBIFORMIS - There are provided a highly safe epimerase usable in food industry, and a method for producing a ketose. The epimerase is a ketose 3-epimerase obtainable from a microorganism of the genus | 2015-12-03 |
20150344926 | Enzyme Hyaluronan-Lyase, Method of Production Thereof, Use Thereof and Method of Preparation of Low-Molecular Hyaluronan - The invention relates to an enzyme which is able to degrade hyaluronic acid and which is produced by fungi of the genus | 2015-12-03 |
20150344927 | Pairing Code Directed Assembly - Provided herein is a method comprising: producing a first complex by annealing: a first nucleic acid comprising, in order, a first unique sequence, a first central sequence and a second unique sequence; and a second nucleic acid comprising, in order, said second unique sequence, a second central sequence and a third unique sequence; wherein the first, second and third unique sequences do not hybridize with each other; subjecting said first complex to multiple rounds of primer extension to extend the first and second nucleic acids using each other as a template, thereby producing a first product molecule that contains, in order, the first unique sequence, the first central sequence, the second unique sequence, the second central sequence and the third unique sequence; and circularizing said first product molecule by intramolecularly ligating the ends of said product molecule together. Kits and compositions relating to the method are also provided. | 2015-12-03 |
20150344928 | GLYCOSYLATION METHOD - The invention relates to microbial host cells engineered to produce glycoconjugate vaccines by stable integration of an acceptor protein and an oligosaccharyltransferase into the host's genome, wherein expression of the oligosaccharyltransferase is regulated. | 2015-12-03 |
20150344929 | BIOSENSOR, THIN FILM ELECTRODE FORMING METHOD, QUANTIFICATION APPARATUS, AND QUANTIFICATION METHOD - A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition. | 2015-12-03 |
20150344930 | CODON-OPTIMIZED RECOMBINANT PHAGE AND METHODS OF USING SAME - Composition and methods for the detection of one or more target microbe(s) are provided. Compositions of the disclosure include at least one recombinant phage capable of infecting a target microbe, said phage comprising at least a capsid protein sequence, a ribosome binding site, and a codon-optimized marker. Compositions of the disclosure may further include an aqueous solution that enhances the ability to detect marker expression upon phage infection of the target microbe. In some embodiments the target microbe include is | 2015-12-03 |
20150344931 | MICROBIAL DETECTION SYSTEM AND METHODS - The disclosure provides culture devices and methods for a microorganism in a sample. The devices include a base member, a cover sheet, an adhesive layer coupled to the base member or the cover sheet, and a cold water-soluble gelling agent disposed on the base member; wherein the devices are substantially optically transmissive when the gelling agent is hydrated with a clear liquid. Methods of use include detecting or enumerating microorganisms. The methods further provide for detecting a microorganism by detecting the presence or size of an abiogenic gas bubble in a culture device. | 2015-12-03 |
20150344932 | METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION - The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engine˜red mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes. | 2015-12-03 |
20150344933 | BIOMARKERS FOR RAPID DETECTION OF AN OCCURRENCE OF A STROKE EVENT - A diagnostic assay for detecting an occurrence of a stroke event in a mammalian subject. The assay comprises the steps of: (i) separating a plasma fraction from a blood sample collected from the mammalian subject; (ii) quantifying in the plasma fraction a L-glutamine hydroxylamine glutamyl transferase (L-GHGT) activity; (iii) quantifying in the plasma fraction a gamma glutamyl hydroxamate synthetase (GGHS) activity; (iv) adding together or alternatively calculating the combinatorial probability for the quantified L-GHGT activity and the quantified GGHS activity to produce a value for the net glutamine synthetase activity, and (v) correlating the net glutamine synthetase activity value with net glutamine synthetase activity values from healthy subjects to detect an occurrence of a stroke event in the mammalian subject. Also disclosed are kits comprising reagents and instructions for performing a diagnostic assay to detect and quantify L-GHGT activity and/or GGHS activity. | 2015-12-03 |
20150344934 | Novel High Throughput Assay for finding new Jak3 Interacting Compounds, Biomolecules, and Inhibitors. - Janus Kinase 3 is a non-receptor tyrosine kinase that mediates signals initiated by cytokines through interactions with the receptors of cytokines. Abnormal activation of Jak3 was associated with human hematologic and epithelial malignancies. Inhibitors of Jak3 have shown utility in many different disease such as autoimmune disorders, allograft rejection during transplantation, acute lymphoblastic leukemia, Type 1 diabetes, rheumatoid arthritis and allergy and asthma. Since these inhibitors make their way into clinical trials with profound effects, it is essential to develop a sensitive, precise, and rugged screening tool to screen synthetic compounds or other biomolecules that has the potential to modulate Jak3 functions and hence treat a wide variety of diseases. Present invention relates to novel high throughput system for finding previously unknown Jak3 interacting compounds, human biomolecule (e.g. proteins or others), and those compounds that can inhibit Jak3 activations. All these identified compounds and molecules can be used for the treatment of a wide variety of diseases (listed in table 1) where Jak3 activations or its interactions with other biomolecules are essential for disease sustenance or propagation in human body. | 2015-12-03 |
20150344935 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS - The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate. | 2015-12-03 |
20150344936 | COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF - There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1). | 2015-12-03 |
20150344937 | OLIGONUCLEOTIDE-MEDIATED QUANTITATIVE MULTIPLEXED IMMUNOASSAYS - Methods and compositions for quantitative immunoassays are provided, in which ligand-conjugated probes are used to label samples and ligand-surfaced microspheres are used as quantitative reference standards. Certain embodiments provide a method of quantitative flow cytometry where ligands are oligonucleotides, and a sample comprising one or more cells is contacted with a hybridized antibody::fluorophore labeled targeting construct to label the cells, and the labeled cells are analyzed. In some embodiments, a population of quantitative labeled oligospheres labeled with the same fluorescent label as the cells is analyzed using the flow cytometer and used to create a quantitative standard curve of cytometer intensity versus molecules fluorescent label per oligosphere event. A standard curve trendline is established and used to determine the molecules of fluorescent label per cellular event for the antigen-positive cell populations. Based on molecules of fluorescent label per cell, the amount of Antibody Binding per Cell (ABC) is quantified. | 2015-12-03 |
20150344938 | MULTIPLEX TRANSCRIPTOME ANALYSIS - In some embodiments, the disclosure relates generally to methods, compositions, systems, apparatuses and kits comprising a multiplex nucleic acid amplification reaction that employs a plurality (e.g., hundreds, thousands, tens-of-thousands or hundreds-of-thousands) of different target-specific primer pairs that enable substantially simultaneous amplification of a plurality of different target sequences-of-interest in a single reaction mixture. In some embodiments, the multiplex nucleic acid amplification reaction generates a plurality of amplicons having sequences derived from a sample containing RNA or DNA, including whole transcriptome or genomic samples. In some embodiments, the sequences and abundances of at least some of the plurality of amplicons are characterized, optionally simultaneously or through a single assay, by suitable detection methods, including sequencing or other procedures known in the art. | 2015-12-03 |
20150344939 | Methods and Compositions For Sorting and/or Determining Organisms - This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to selectively stain the organisms or cells in combination with the use of binding partners to selectively immobilize the stained organisms or cells to a solid carrier. By combining the selectivity of both molecular probes and binding partners in an orthogonal method for staining and immobilization, these methods and compositions increase both the discriminating power of the assays and/or the certainty of the result obtained therefrom. | 2015-12-03 |
20150344940 | BIOMARKERS OF RECURRENT CLOSTRIDIUM DIFFICILE INFECTION - Embodiments of the invention include methods and/or compositions for analysis of samples for | 2015-12-03 |
20150344941 | RECOGNITION-RELEASE NANOPOROUS SUBSTRATE COMPRISING ACTIVE AGENTS, METHODS OF THEIR PREPARATION AND USES - The present invention relates to a porous substrate comprising at least one active agent entrapped within said pores of said substrate; wherein said pores are capped by at least one nucleic acid sequence; said agent is being released by a triggered reaction of said capping sequence with at least one analyte (biomarker) thereby allowing said capping to be cleaved from said pore. The invention further relates to methods of manufacturing said substrate, uses thereof for the controlled administration of active agents and diagnostic of conditions in a patient. | 2015-12-03 |
20150344942 | METHODS AND PRODUCT FOR OPTIMISING LOCALISED OR SPATIAL DETECTION OF GENE EXPRESSION IN A TISSUE SAMPLE - The present invention relates to methods and products for localized or spatial detection and/or analysis of RNA in a tissue sample or a portion thereof, comprising: (a) providing an object substrate on which at least one species of capture probe, comprising a capture domain, is directly or indirectly immobilized such that the probes are oriented to have a free 3′ end to enable said probe to function as a reverse transcriptase (RT) primer; (b) contacting said substrate with a tissue sample and allowing RNA of the tissue sample to hybridise to the capture probes; (c) generating cDNA molecules from the captured RNA molecules using said capture probes as RT primers; (d) labelling the cDNA molecules generated in step (c), wherein said labelling step may be contemporaneous with, or subsequent to, said generating step; (e) detecting a signal from the labelled cDNA molecules; and optionally (f) imaging the tissue sample, wherein the tissue sample is imaged before or after step (c). | 2015-12-03 |
20150344943 | METHODS AND SYSTEMS FOR NUCLEIC ACID AMPLIFICATION - The disclosure provides methods and systems for nucleic acid amplification including isothermal nucleic acid amplification. | 2015-12-03 |
20150344944 | ANALYSIS OF A POLYNUCLEOTIDE VIA A NANOPORE SYSTEM - A target polynucleotide is expanded. In respect of each nucleotide in the target polynucleotide, the target polynucleotide comprises clock nucleotides and at least one signal nucleotide in a predetermined order. The clock nucleotides have a predetermined sequence common to each nucleotide in the target polynucleotide. The at least one signal nucleotide is characteristic of the identity of the respective nucleotide in the target polynucleotide. During translocation of the expanded polynucleotide through a nanopore, electrical measurements dependent on the polynucleotide within the pore are made, to derive an analysis signal. Clock signals derived from the clock nucleotides are identified. Relative to the positions of the identified clock signals, nucleotide signals derived from the least one signal nucleotide are derived to analyse the target polynucleotide. The predetermined sequence of the clock nucleotides comprises a restriction site for a restriction enzyme and at least one further nucleotide that extends the predetermined sequence. | 2015-12-03 |
20150344945 | COMPOSITIONS, SYSTEMS, AND METHODS FOR DETECTING EVENTS USING TETHERS ANCHORED TO OR ADJACENT TO NANOPORES - Compositions, systems, and methods for detecting events are provided. A composition can include a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and a permanent tether including head and tail regions and an elongated body disposed therebetween. The head region can be anchored to or adjacent to the first or second side of the nanopore. The elongated body including a reporter region can be movable within the aperture responsive to a first event occurring adjacent to the first side of the nanopore. For example, the reporter region is translationally movable toward the first side responsive to the first event, then toward the second side, then toward the first side responsive to a second event. The first event can include adding a first nucleotide to a polynucleotide. The second event can include adding a second nucleotide to the polynucleotide. | 2015-12-03 |
20150344946 | METHOD FOR HIGH-THROUGHPUT AFLP-BASED POLYMORPHISM DETECTION - The invention relates to a method for the high throughput discovery, detection and genotyping of one or more genetic markers in one or more samples, comprising the steps of restriction endonuclease digest of DNA, adaptor-ligation, optional pre-amplification, selective amplification, pooling of the amplified products, sequencing the libraries with sufficient redundancy, clustering followed by identification of the genetic markers within the library and/or between libraries and determination of (co-)dominant genotypes of the genetic markers. | 2015-12-03 |
20150344947 | GENOTYPING BY NEXT-GENERATION SEQUENCING - Provided herein is technology relating to genotyping and particularly, but not exclusively, to methods for genotyping one or more organisms by genome sequencing. | 2015-12-03 |
20150344948 | UNIVERSAL SANGER SEQUENCING FROM NEXT-GEN SEQUENCING AMPLICONS - Described herein are methods, compositions and kits directed to amplification of nucleic acids suitable for both next generation sequencing (NGS) and a second round of sequencing as validation, such as Sanger sequencing. | 2015-12-03 |
20150344949 | COMBINED METHODOLOGY USED TO DETECT THE PRESENCE OF POSSIBLE CONTAMINATING EVENTS - Disclosed herein are methods for determining if a contaminating integration of a nucleotide sequence is present in a set of nucleic acids. Further disclosed herein are methods for determining the copy number/zygosity of a nucleic acid sequence of interest. The methods disclosed herein may be performed using quantitative PCR. | 2015-12-03 |
20150344950 | Functionalized Cyanine Dyes (PEG) - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 2015-12-03 |
20150344951 | PRE-IMPLANTATION GENDER SCREENING KIT AND METHOD - A kit and method for determining the gender of a human's or other mammal's pre-implantation embryo with increased accuracy. The method comprises exposing genetic material from one or more cells removed from the embryo to multiple labeled hybridization agents that will detect markers associated with (1) the Y chromosome, but not the X chromosome, (2) the X chromosome, but not the Y chromosome, and (3) both X and Y chromosomes. The gender is determined by detecting the presence or absence of labeled hybridized agents in the sample after washing, or indicates that the test results are not reliable. The kit contains labeled hybridization agents for conducting the pre-implantation gender screening method. | 2015-12-03 |
20150344952 | DNA MARKERS FOR BEEF TENDERNESS IN CATTLE - The present invention provides genetic polymorphisms and methods for identifying said genetic polymorphisms associated with desired beef tenderness in cattle, as well as kits for identifying said polymorphisms in beef cattle. The invention also provides methods of predicting the tenderness of beef in a head of cattle before slaughter based on the presence of a hapblock conferring tenderness. In other embodiments, the invention provides methods of determining a breeding value for a head of cattle involving detection of such polymorphisms. | 2015-12-03 |
20150344953 | RNF41 AS A BIOMARKER PREDICTING RESPONSE TO LENALIDOMIDE IN NON-DEL(5Q) MDS - Disclosed herein is a method of using erythroid expression levels of RNF41 as a predictive biomarker for responsiveness to lenalidomide (LEN) in patients with non-del(5q) MDS. | 2015-12-03 |
20150344954 | Detection of Brain Injury - The present invention provides minimally invasive methods of detecting, diagnosing, and assessing neuronal damage associated with traumatic brain injury (TBI) or chronic traumatic encephalopathy (CTE). Specific species of microRNAs (miRNA), small, noncoding RNA molecules that play gene regulatory functions, are correlated with cellular damage and oxidative stress following TBI or CTE, allowing for rapid, minimally-invasive diagnosis and assessment of brain injury. The early identification and longitudinal assessment of neuronal damage in subjects suffering from or at risk of suffering from a TBI (e.g., football players, boxers, military personnel, fall victims) will improve clinical outcomes by guiding critical medical and behavioral decision making. | 2015-12-03 |
20150344955 | METHODS FOR DETECTION AND QUANTIFICATION OF EGFRvIII IN THE PERIPHERAL BLOOD OF GBM PATIENTS - Methods and kits for detection and quantification of EGFRvIII in the peripheral blood for monitoring the therapy of a GBM patients. | 2015-12-03 |
20150344956 | Methods For The Diagnosis Of Fetal Abnormalities - The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject. | 2015-12-03 |
20150344957 | MONITORING TREATMENT OF HISTIOCYTOSIS WITH VEMURAFENIB AND DABRAFENIB - Provided are methods of determining the amount of a BRAF V600E mutation over time in a subject with Langerhans Cell Histiocytosis (LCH) or Erdheim-Chester Disease (ECD) who is being treated with vemurafenib or dabrafenib. | 2015-12-03 |
20150344958 | A SCREENING METHOD, A KIT, A METHOD OF TREATMENT AND A COMPOUND FOR USE IN A METHOD OF TREATMENT - A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, by bringing a compound into contact with cells that express a GPCR and that further express a GRK, determining whether the contacting causes a response of the GRK in cells brought into contact with the compound, determining whether the contacting causes a response of a classical secondary messenger in cells brought into contact with the compound; and identifying the candidate compound based on the determined GRK response and response of a classical secondary messenger in the cells. A kit for use in the method. A compound for use in the treatment of a condition involving dysregulation of metabolism in a mammal and a method of treatment of such a condition. | 2015-12-03 |
20150344959 | COMPOSITIONS AND METHODS FOR GENOTYPING CANINES - Provided are compositions and methods for use in genotyping canines. The compositions and methods are useful for determining canine genotypes related to certain canine phenotypes, including shedding and/or long hair, body size, and ear type. The compositions and methods involve determining single nucleotide polymorphisms in biological samples obtained from canines. | 2015-12-03 |
20150344960 | Single Nucleotide Polymorphisms (SNPs) in Genes Accociated With Inflammatory Diseases - The present disclosure describes the identification of single nucleotide polymorphisms (SNPs) in inflammatory diseases and uses thereof, and methods of screening for, diagnosing, identifying susceptibility to or detecting a risk of developing an inflammatory disease comprising detecting the presence or absence of at least one SNP identified in a gene associated with inflammatory disease. | 2015-12-03 |
20150344961 | Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma - The present invention relates to serum marker microRNAs (miRNAs) which are associated with cancer, particularly melanoma, and to the assessment thereof in the prognosis, treatment and management of cancer. Embodiments include methods, compositions, kits and isolated nucleic acids. The present invention is directed to methods and compositions for prognosing melanoma and monitoring for recurrence by monitoring serum miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing risk and/or likelihood of recurrence in a melanoma patient. The present invention relates to biomarkers for melanoma, particularly serum markers and sets thereof which are relevant and significant as prognostic indicators of melanoma disease and patient risk for recurrence. | 2015-12-03 |
20150344962 | METHODS FOR EVALUATING BREAST CANCER PROGNOSIS - Methods for diagnosing and for evaluating the prognosis of a cancer patient, particularly a breast cancer patient, are provided. The methods include determining expression levels of at least five biomarkers in a body sample including a cancer cell from the patient, where expression levels of the biomarkers are indicative of cancer prognosis. Overexpression of the biomarkers of the invention is indicative of a poor prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The methods of the invention can be used in combination with assessment of conventional clinical factors and permit a more accurate evaluation of breast cancer prognosis. | 2015-12-03 |
20150344963 | DIAGNOSTIC MARKERS FOR TREATING CELL PROLIFERATIVE DISORDERS WITH TELOMERASE INHIBITORS - Provided herein are methods for identifying individuals diagnosed with a cell proliferative disorder that will benefit from treatment with a telomerase inhibitor compound. Also provided herein are methods for treating these individuals with telomerase inhibitor compounds. The methods comprise identifying individuals who will benefit from said treatment based on the average relative length of telomeres in cancer cells from said individuals. | 2015-12-03 |
20150344964 | PREDICTION OF THE TREATMENT RESPONSE TO AN ANTI-EGFR MOLECULE IN COLORECTAL CANCER PATIENTS - The present invention relates to a method for predicting the treatment response to an anti-epidermal growth factor receptor (EGFR) molecule in a patient suffering from colorectal cancer. Furthermore, the present invention relates to an anti-EGFR molecule for use in the treatment of a patient suffering from colorectal cancer. | 2015-12-03 |
20150344965 | Compositions and Methods for Treating or Preventing Prostate Cancer and for Detecting Androgen Receptor Variants - The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related diseases or disorders. | 2015-12-03 |
20150344966 | Hereditary Cancer Diagnostics - The disclosure generally relates to a molecular classification of disease predisposition and particularly to molecular markers for cancer predisposition and methods of use thereof. | 2015-12-03 |
20150344967 | PREDICTING LIKELIHOOD OF RESPONSE TO COMBINATION THERAPY - Provided are methods of determining whether a subject having ER+ breast cancer is expected to benefit from treatment with combination endocrine therapy and mTOR inhibitor therapy. Also provided are methods of treating a subject having ER+ breast cancer. | 2015-12-03 |
20150344968 | METHODS FOR DETERMINING PARP INHIBITOR AND PLATINUM RESISTANCE IN CANCER THERAPY - Systems and methods for determining whether a cancer patient may respond to PARP inhibitor and/or platinum chemotherapy based on identifying exon excision variants in the BRCA 1 gene are provided. Exon excision variants may encode a hypomorphic BRCA1 protein. The cancer patient may be a breast cancer patient or an ovarian cancer patient. The patient may have any cancer in which exon deficiency in the BRCA1 gene contributes to resistance to PARP inhibitor or platinum therapy. | 2015-12-03 |
20150344969 | COMPOSITIONS AND METHODS FOR DETECTING NEOPLASIA - Compositions and methods for the diagnosis, treatment, and prevention of neoplasia (e.g., colorectal cancer). | 2015-12-03 |
20150344970 | Personalized Tumor Biomarkers - Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients. | 2015-12-03 |
20150344971 | METHOD FOR DIAGNOSIS, PROGNOSIS AND DETERMINATION OF TREATMENT FOR CUTANEOUS T-CELL LYMPHOMA - The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment. | 2015-12-03 |
20150344972 | COMPOSITIONS COMPRISING SOLUBLE CD84 OR ANTI-CD84 ANTIBODIES AND METHODS FOR DIAGNOSING AND TREATING B-CLL - A method of diagnosing B-CLL in a subject in need thereof is provided. The method comprising determining in a biological sample of the subject a level of CD84 isoform C (SEQ ID NO: 30), wherein an increase in the level of the CD84 isoform C (SEQ ID NO: 30) beyond a predetermined threshold with respect to a level of the CD84 in a biological sample from a healthy individual is indicative of the B-CLL. | 2015-12-03 |
20150344973 | Method and System for Detection of an Organism - The invention provides, inter alia, systems, compositions, kits and methods for detecting an organism, such as a microbe, microorganism, pathogen, or organism associated with Hospital Associated Infections (HAIs). The systems, compositions, kits and methods can comprise one or more probes for detecting a strain with high sensitivity, high specificity, or both. The systems, compositions, kits and methods can also be used to detect the strain within a short time frame. | 2015-12-03 |
20150344974 | DNA MARKERS FOR FEED EFFICIENCY IN CATTLE - The present invention provides genetic polymorphisms and methods for identifying said genetic polymorphisms associated with feed efficiency in cattle, as well as kits for identifying said polymorphisms in beef cattle. The invention also provides methods of predicting the feed efficiency of beef in a head of cattle based on the presence of a hapblock conferring feed efficiency. In other embodiments, the invention provides methods of determining a breeding value for a head of cattle involving detection of such polymorphisms. | 2015-12-03 |
20150344975 | COMPOSITIONS AND METHODS FOR DETECTING, EXTRACTING, VISUALIZING, AND IDENTIFYING PROTOMYXZOA RHUEMATIC - Disclosed are compositions, kits, and methods for detecting, extracting, visualizing, and identifying Protomyxzoa Rhuematic. | 2015-12-03 |
20150344976 | DIAGNOSIS AND TREATMENT OF VIRAL DISEASES - This disclosure relates to methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. The disclosure further relates to methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, in addition, the disclosure relates to methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. The disclosure further relates to methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection. | 2015-12-03 |
20150344977 | Method And System For Detection Of An Organism - Provided herein are systems and method of detecting an organism, such as a microbe, microorganism or pathogen. The system can comprise one or more probi for detecting a strain with high sensitivity. The system can also detect the strain within a short time frame. | 2015-12-03 |
20150344978 | NICOTINE RESISTANT MICROORGANISMS - Compositions and methods are provided for enhanced production of ethanol from fermentation of tobacco biomass. Nicotine resistant microorganisms are provided, as well as methods for making these nicotine resistant microorganisms. A biologically pure culture is provided of a nicotine resistant | 2015-12-03 |
20150344979 | HIDE ROUTING SYSTEMS AND METHODS - Methods and systems for processing raw animal hides into leather are provided. In particular, one or more embodiments comprise a tanning manager that directs the routing of hides to a plurality of tanning drums. This allows the tanning manager to efficiently use the capacity of the plurality of tanning drums and provides improved consistency in the tanning of the hides. Furthermore, one or more embodiments enable the tanning manager to route hides to tanning drums based on various factors, such as hide type, hide weight, and hide size. In addition, one or more embodiments provide the tanning manager with greater control over the processing of hides into leather by customizing the tanning recipes applied to each batch of hides. | 2015-12-03 |
20150344980 | HIDE SORTING SYSTEMS AND METHODS - Methods and systems for sorting hides are provided. In particular, one or more embodiments comprise a tanning control system that enhances the traceability of hides by capturing and utilizing data related to the unloading, tanning, sorting, and packaging of hides. Furthermore, one or more embodiments enable the tanning control system to improve efficiency by sorting hides based, at least in part, on data generated during prior tanning processes. Additionally, one or more embodiments facilitate the tanning control system in customizing the sorting and packaging of hides based, at least in part, on one or more hide characteristics and/or customer specifications. | 2015-12-03 |
20150344981 | A Scraping Wheel, a Scraping Roller and Use of a Scraping Wheel - Disclosed is a scraping wheel ( | 2015-12-03 |
20150344982 | LANCE AND OPERATION METHOD USING THE SAME - Provided is a lance and an operation method using the same, in which a suction hole allowing source gas to be injected into a container, in which a reaction gas is generated, is included. The suction hole is formed in a source gas passage where the reaction gas is introduced into the passage. Thus the temperature of the gas injected into the container may be easily increased without using any separate heating device, and secondary combustion efficiency may be increased. In addition, the gas sprayed at a high temperature is provided, and thus additional heat may be supplied into the container. Thus, excessive use of fuel used to increase the temperature of the container may be avoided, and thus operation costs may be reduced and operation efficiency and productivity may be increased. | 2015-12-03 |
20150344983 | FIXED-TYPE ELECTRIC FURNACE AND MOLTEN STEEL PRODUCTION METHOD - Provided are a fixed-type electric furnace enabling continuous operation which allows melting without the interruption of power supply and tapping in a fixed state, and a fixed-type electric furnace and a molten steel production method using same. The fixed-type electric furnace comprises: a preheating furnace which is disposed on the side of a melting furnace and preheats an iron source (scrap) using exhaust gas from the melting furnace; a supply means for supplying the iron source, which has been preheated in the preheating furnace, to the melting furnace; the melting furnace comprising electrodes for melting the preheated iron source; and a fixed-type discharge means for discharging molten steel which has been melted in the melting furnace, wherein the preheating furnace is integrally connected to the melting furnace. | 2015-12-03 |
20150344984 | ULTRASOUND-ASSISTING QUENCHING PROCESS AND DEVICE FOR PERFORMING THE SAME - An ultrasound-assisting quenching process includes: S1) connect the workpiece with the ultrasonic unit tightly; S2) heat the workpiece to the quenching temperature and then hold for a period of time; S3) start the ultrasonic unit, then the ultrasound energy can be injected into the workpiece directly; and S4) put the workpiece into the coolant quickly to make the workpiece to be quenched. The device for this process mainly includes the ultrasonic unit and a heating unit. This invention inputs the ultrasound energy into the workpiece during the quenching process. Under the action of the ultrasound, the grain size of the workpiece after quenching process will be much smaller compared with the conventional quenching process. Therefore, the ultrasound-assisting quenching process can improve the strength and plasticity of the material, and extend the life of the workpiece. | 2015-12-03 |
20150344985 | INDUCTION HEATING APPARATUS, CARRIERS, AND METHODS FOR HEAT TREATING PARTS - An apparatus includes rails for supporting sides of a circumferential peripheral edge of a carrier. A movable ram engages a rearward portion of the carrier. A movable restrainer restrains movement of the ram. A wheel engages a forward portion of the carrier. A controller is operable to control the movable restrainer to restrain movement of the ram with the carrier and at least one metal object disposed adjacent an induction heating device, the wheel to rotate the carrier and the metal object, the induction heating device to induction heat the rotating metal object, and the movable restrainer to disengage the ram so that the wheel pivots away to allow passage of the carrier and the heated metal object into a quench bath. A plurality of metal objects may be arranged in a circular array in the carrier about a diameter generally equal to the diameter of an induction coil. | 2015-12-03 |
20150344986 | HEAT TREATMENT APPARATUS FOR HOT STAMPING AND FORMING METHOD USING THE SAME - A heat treatment apparatus for hot stamping includes a frame, and heating units provided to be vertically movable at both upper and lower sides of the frame and configured to heat a cold formed steel plate by electrifying the steel plate. Cooling units are provided to be vertically movable at centers of the upper and lower sides of the frame and are configured to cool the heated steel plate while pressurizing the steel plate from upper and lower sides. | 2015-12-03 |
20150344987 | METHOD AND APPARATUS FOR PERFORMING A LOCALIZED POST-WELD HEAT TREATMENT ON A THIN WALL METALLIC CYLINDER - A method of performing a localized post weld heat treatment on a weld seam in a thin wall metallic body may include attaching thermocouples to the outside surface of the weld seam and covering the weld seam with a thermal insulating blanket. Cooling bands are attached to the outside of the body on both sides of the weld seam. An inert atmosphere enclosure with inlet and exhaust ports is fitted over the weld seam, thermal insulating blanket, and cooling bands. A power supply and control system for an induction coil or coils situated in close proximity to the weld seam are actuated and the weld seam is subjected to a heat treatment without thermally affecting regions of the metallic body adjacent to the weld seam and external to the cooling bands. | 2015-12-03 |
20150344988 | PROCESS FOR REDUCING OF LEACHABLE FLUORIDES AND CONTROLLING PH OF ALUMINUM WASTE PRODUCTS - The present disclosure provides processes for recycling spent pot lining carbon by-products (SPLCB) obtained from a caustic leach process. The process provides treating spent pot lining (SPL) or SPLCB with Ca/P-containing stabilizing agents. | 2015-12-03 |
20150344989 | COMPOSITE BRIQUETTE FOR STEELMAKING OR IRONMAKING FURNACE CHARGE - A briquette for addition to the charge in a steelmaking or ironmaking furnace comprises a quantity of carbon fines, a material in powdered form, the material selected from the group consisting of iron powder and iron oxide, the material densifying the briquette and suppressing the slippery nature of the carbon fines, a quantity of magnesium carbonate, and a binder. | 2015-12-03 |
20150344990 | HYDROMETALLURGICAL TREATMENT PROCESS FOR EXTRACTION OF METALS FROM CONCENTRATES - This invention relates to a hydrometallurgical process for extracting platinum group metals (PGMs), gold, silver and base metals from a flotation concentrate ( | 2015-12-03 |
20150344991 | METHOD FOR RECOVERING RARE EARTH ELEMENT - An object of the present invention is to provide a method for recovering a rare earth element from a workpiece containing at least a rare earth element and an iron group element, which can be put into practical use as a low-cost, simple recycling system. The method for recovering a rare earth element from a workpiece containing at least a rare earth element and an iron group element of the present invention as a means for resolution is characterized by including at least a step of separating a rare earth element in the form of an oxide from an iron group element by subjecting a workpiece to an oxidation treatment, then turning the treatment environment into an environment where carbon black is present, and subjecting the oxidation-treated workpiece to a heat treatment at a temperature of 1000° C. or more in an inert gas atmosphere or in vacuum. | 2015-12-03 |
20150344992 | MANUFACTURING METHOD OF ALUMINUM ALLOY IN WHICH AL-FE-SI COMPOUND IS REFINED - A manufacturing method of an inexpensive aluminum alloy that allows fine crystallization of the Al—Fe—Si compound and primary Si by employing a convenient and efficient means. To a molten aluminum alloy including 8 to 20% by mass of Si; 0.5 to 4% by mass of Fe; and, as necessary, at least any one of Mn and Cr; at least any one of Ni, Cu, and Mg; P; and the balance being Al and impurities, AlB | 2015-12-03 |
20150344993 | TITANIUM-BASED ALLOYS AND ARTICLES FORMED FROM SUCH ALLOYS - Article(s) are disclosed that are formed, at least in part, by a titanium-based alloy having about 35 to about 55 wt. % or greater titanium, the article(s) have a hardness of about 1350 HV or greater, and a coloration characterized by an L value of about 56.00 to about 60.00, an a value of about 1.0 to about 1.5, and a b value of about 3.65 to about 3.75, wherein the L, a, and b values are color values according to the CIE L*a*b* color scale. | 2015-12-03 |
20150344994 | GAMMA PRIME PRECIPITATION STRENGTHENED NICKEL-BASE SUPERALLOY FOR USE IN POWDER BASED ADDITIVE MANUFACTURING PROCESS - The application relates to the technology of producing three-dimensional articles by means of powder-based additive manufacturing, such as selective laser melting (SLM) or electron beam melting (EBM). It refers to a Nickel-base superalloy powder, wherein the superalloy powder has a chemical composition that allows establishing a gamma-prime precipitation content of 60-70 vol.-% in the superalloy in a heat treated condition. The powder has a powder size distribution between 10 and 100 μm and a spherical morphology. The ratios of the content (in weight-%) of the alloying elements C, B, Hf, Zr, Si are the following:
| 2015-12-03 |
20150344995 | METALLIC NICKEL-BASED ACID-RESISTANT MATERIAL - A nickel-molybdenum-iron alloy with high corrosion resistance with respect to reducing media at high temperatures, consisting of (in % by mass): 61 to 63% nickel, 24 to 26% molybdenum, 10 to 14% iron, 0.20 to 0.40% niobium, 0.1 to 0.3% aluminum, 0.01 to 1.0% chromium, 0.1 to 1.0% manganese, at most 0.5% copper, at most 0.01% carbon, at most 0.1% silicon, at most 0.02% phosphorus, at most 0.01% sulphur, at most 1.0% cobalt, and further smelting-related impurities. | 2015-12-03 |
20150344996 | STEEL MATERIAL AND IMPACT ABSORBING MEMBER - The steel material for an impact absorbing member has a composition containing: by mass %, C: 0.05 to 0.18%, Mn: 1 to 3%, Si+Al: at least 0.5% and less than 2.5%, and N: 0.001 to 0.015%, and in some cases, Cr: at most 0.5%, Mo: at most 0.2%, Ti: at most 0.05%, Nb: at most 0.05%, V: at most 0.2%, and B: at most 0.002%, the remainder being Fe and impurities. The steel material structure contains at least 70% by area of bainite made up of a lath structure having an average interval of at most 1 mm and martensite, 5 to 30%, and satisfies Formulas (1) and (2): (1) 1.2 £ H | 2015-12-03 |
20150344997 | BAINITIC STEEL FOR ROCK DRILLING COMPONENT - A bainitic steel comprising, in weight % (wt %): C: 0.16-0.23, Si: 0.8-1.0, Mo: 0.67-0.9, Cr: 1.10-1.30, V: 0.18-0.4, Ni: 1.60-2.0, Mn: 0.65-0.9, P: ≦0.020, S: ≦0.02, Cu: <0.20, N: 0.005-0.012 balance Fe and unavoidable impurities. | 2015-12-03 |
20150344998 | HOT ROLLED STEEL SHEET AND METHOD FOR MANUFACTURING THE SAME - A high strength hot rolled steel sheet is provided with low yield ratio and that is excellent in low-temperature toughness. The hot rolled steel sheet can be used as a raw material of a steel pipe. The steel sheet has a chemical composition containing C: 0.03% or more and 0.10% or less, Si: 0.01% or more and 0.50% or less, Mn: 1.4% or more and 2.2% or less, P: 0.025% or less, S: 0.005% or less, Al: 0.005% or more and 0.10% or less, Nb: 0.02% or more and 0.10% or less, Ti: 0.001% or more and 0.030% or less, Mo: 0.01% or more and 0.50% or less, Cr: 0.01% or more and 0.50% or less, and Ni: 0.01% or more and 0.50% or less, in which the condition that Moeq is 1.4% or more and 2.2% or less. | 2015-12-03 |
20150344999 | GOLD-ALUMINUM GLASSES BEARING RARE-EARTH METALS - The disclosure provides Au—Al-Rare-Earth metallic glass-forming alloys and metallic glasses comprising various other additions including but not limited to Cu, Pd, Sn and Mg. In certain embodiments, the metallic glasses according to the disclosure satisfy the 18-Karat Gold Alloy Hallmark, and demonstrate colors that include yellow and pink/rose. | 2015-12-03 |
20150345000 | AMORPHOUS ALLOY AND METHOD FOR PREPARING THE SAME - An amorphous alloy and a method for preparing the amorphous alloy are provided. The amorphous alloy is represented by a formula of (Zr,Hf) | 2015-12-03 |
20150345001 | DISCOLORATION-RESISTANT GOLD ALLOY - Alloy for the manufacturing of jewels or clock components with minimum concentrations of gold of 75 wt %, of copper between 5% and 21%, of silver between 0% and 21%, of iron between 0.5% and 4% and vanadium between 0.1% and 2.0%, intended to increase the tarnishing-resistance of alloys with a minimum content of gold of 75 wt % under environments in which sulphur- and chlorine-compounds are present. | 2015-12-03 |
20150345002 | Method for Hot-Dip Coating of a Steel Flat Product - The invention specifies a method which allows process-stable hot-dip coating of Ni-alloy steel flat products in a cost- and resource-effective manner, comprising the following steps:
| 2015-12-03 |
20150345003 | METAL MEMBER OF A MOVING SYSTEM OF AN INTERNAL COMBUSTION ENGINE AND METHOD FOR MANUFACTURING THE METAL MEMBER - A metallic member for a mobile system of an internal combustion engine may include a body defining a crystallographic structure. The crystallographic structure may include an outer layer, a substrate and a saturated zone between the outer layer and the substrate. An external element may be dispersed at least partially through the crystallographic structure of the body. The body may be subjected to a superficial hardening treatment from infiltrating the external element into the crystallographic structure of the body via a laser beam penetrating at least one portion of an outer surface of the outer layer of the body. | 2015-12-03 |
20150345004 | METHOD FOR TREATING PLATE - A method for locally treating a plate is disclosed. A pattern formed from a compound containing at least one alloying element is applied onto at least one surface of the plate. At least the surface of a contacting layer including the pattern is covered by adequately heat-resistant material. The plate is subsequently heat treated in order to diffuse the alloying element into the plate. | 2015-12-03 |
20150345005 | Seed layer for low-e applications - Methods, and coated panels fabricated from the methods, are disclosed to form multiple coatings, (e.g., one or more infrared reflective layers), with minimal color change before and after heat treatments. For example, by adding appropriate seed layers between the IR reflective layers and the base oxide layers, the color performance can be maintained regardless of high temperature processes. The optical filler layers can include a metal oxide layer. In some embodiments, the seed layer can include nickel, titanium, and niobium, forming a nickel titanium niobium alloy such as NiTiNb. | 2015-12-03 |
20150345006 | TRANSPARENT CONDUCTING INDIUM DOPED TIN OXIDE - A method of manufacturing indium tin oxide includes sputtering indium and tin from a target onto a substrate, the sputtering including moving the target along a path over the substrate. The indium tin oxide may have a sheet resistance less than 0.5Ω/□. An indium film includes: a first moving target sputtered indium tin oxide layer; a second moving target sputtered indium tin oxide layer on the first moving target sputtered indium tin oxide layer; and a third moving target sputtered indium tin oxide layer on the second moving target sputtered indium tin oxide layer. A transparency includes the indium tin oxide, and a flying vehicle includes the transparency. | 2015-12-03 |
20150345007 | COMBINATION VAPOR DEPOSITION CHAMBER - This application relates to a combination vapor deposition process chamber. In, some embodiments, a combination vapor deposition process chamber can be used to apply an optical coating to a substrate such as glass, as well as an anti-smudge coating to the same substrate. The combination vapor deposition process chamber can include a sputter target, reactive gas and plasma source, and an anti-smudge coating source. Both sputter deposition and evaporation deposition can be performed with the combination vapor deposition process chamber without exposing the substrate to open air and contaminants between deposition processes. In some embodiments, the combination vapor deposition process chamber uses multiple sub-process chambers connected by a low pressure passageway for transferring substrates between deposition processes. | 2015-12-03 |
20150345008 | HEATING APPARATUS, AND COATING DEVICE COMPRISING SAME - Provided are a heating apparatus configured to generate a coating vapor for coating a base metal (steel sheet) which is continuously transferred in a vacuum state, and a coating device including the heating apparatus. A coating material to be converted into a coating vapor is initially supplied in a solid phase (solid state) and then phase changed into a liquid (liquid state). Thereafter, the liquid-state coating material is supplied to a heating unit, thereby preventing problems such as equipment erosion occurring when a liquid coating material is directly supplied and preventing the decrease of the temperature of a coating material when a solid wire is supplied as a coating material. As a result, the energy efficiency of the heating apparatus may be maximized. | 2015-12-03 |
20150345009 | SUBSTRATE WITH TRANSPARENT ELECTRODE AND METHOD FOR MANUFACTURING SAME - A substrate with a transparent electrode which includes an amorphous transparent electrode layer on a transparent film substrate. When a bias voltage of 0.1 V is applied to the amorphous transparent electrode layer, the layer has continuous regions where a current value at a voltage-applied surface is 50 nA or more. Each of the continuous regions has an area of 100 nm | 2015-12-03 |
20150345010 | METHODS OF MAGNETICALLY ENHANCED PHYSICAL VAPOR DEPOSITION - Methods for magnetically enhanced physical vapor deposition are disclosed. The methods include providing a magnetically enhanced vapor deposition device defining a vapor deposition chamber, having a magnetic field source proximate a magnetron target that is positioned within the vapor deposition chamber and coupled to a power source, and having a substrate holder positioned within the vapor deposition chamber, placing a substrate in the substrate holder, activating the magnetic field source to provide a magnetic field that controls a charged particle flux within the physical vapor deposition chamber, and activating the power source thereby depositing a few-layer film of the material comprising the magnetron target onto the substrate. The few-layer film may be a transition metal dichalcogenide, such as MoS | 2015-12-03 |
20150345011 | DIAMOND ELECTRODE AND METHOD OF MANUFACTURING THE SAME - Disclosed are a method of manufacturing a diamond electrode by a chemical vapor deposition (CVD) process, and a diamond electrode manufactured by the method. The method of manufacturing the diamond electrode includes: introducing a carbon source gas to form niobium carbide (NbC) on a niobium substrate, immediately before depositing an electrically conductive diamond layer on the substrate by a hot-filament chemical vapor deposition (HFCVD) process; and depositing electrically conductive diamond layers on the substrate by two or more separate processes. Accordingly, a pinhole present during deposition of the electrically conductive diamond layer is filled such that the contact between an electrolyte and the substrate in an electrolytic environment will be minimized so as to retard the corrosion of the substrate, thereby providing a diamond electrode having a long life span. | 2015-12-03 |
20150345012 | SURFACE COATED MEMBER AND METHOD FOR MANUFACTURING SAME - A surface coated member having improved stability and a longer service life is provided. The surface coated member of the present invention includes a base member and a hard coating formed on a surface thereof. The hard coating is constituted of one or more layers. At least one of the layers is formed by a CVD method and includes a multilayer structure having a first unit layer and a second unit layer being layered alternately. The first unit layer includes a first compound containing Ti and one or more kind of element selected from the group consisting of B, C, N, and O. The second unit layer includes a second compound containing Al and one or more kind of element selected from the group consisting of B, C, N, and O. | 2015-12-03 |
20150345013 | SURFACE COATED MEMBER AND METHOD FOR MANUFACTURING SAME - A surface coated member having improved stability and a longer service life is provided. The surface coated member includes a base member and a hard coating formed on a surface thereof. The hard coating is constituted of one or more layers. At least one layer among the layers is a layer including hard particles. The hard particles include a multilayer structure having a first unit layer and a second unit layer being layered alternately. The first unit layer includes a first compound. The second unit layer includes a second compound. The first compound and the second compound are respectively made of one or more kind of element selected from the group consisting of a group 4 element, a group 5 element, a group 6 element of a periodic table, and Al, and one or more kind of element selected from the group consisting of B, C, N, and O. | 2015-12-03 |