49th week of 2020 patent applcation highlights part 29 |
Patent application number | Title | Published |
20200377891 | REPROGRAMMING OF NON-NEURONAL CELLS INTO NEURONS AND METHODS AND COMPOSITIONS TO TREAT NEURODEGENERATIVE DISEASES AND DISORDERS - Provided herein is a method of reprogramming a non-neuronal cell to a neuron. Aspects of the present disclosure relate to using cell reprogramming agent suppresses the expression or activity of PTB to convert a non-neuronal cell into a neuron. Also provided herein is a method of treating neurodegenerative disease by reprogramming non-neuronal cells in vivo to functional neurons. | 2020-12-03 |
20200377892 | AN INHIBITOR FOR USE FOR PREVENTING AND/OR TREATING AN INFECTION WITH HEPATITIS B VIRUS - The present invention concerns an inhibitor for use for preventing and/or treating an infection with hepatitis B virus (HBV) and an in vitro screening method for the identification of a candidate compound suitable for preventing and/or treating an infection with hepatitis B virus. Inventors show that the knock-down of histone chaperone HIRA before HBV inoculation led to a strong decrease in HBV cccDNA (covalently closed circular DNA) accumulation and stable rcDNA (relaxed circular DNA) levels, in HepG2-NTCP cell line, indicating either a possible incomplete or delayed rcDNA to cccDNA transition. This effect was independent from HBx protein expression in Primary human hepatocytes (PHH). HIRA is able to interact with cccDNA and its recruitment is concomitant with deposition of histone variant H3.3 in HepG2-NTCP cell line. HIRA was able to interact with HBc (HBV capsid protein) in infected hepatocytes and in an HepaRG cell line expressing HBc in an inducible manner. | 2020-12-03 |
20200377893 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MUTANT EGFR GENE - The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA to inhibit expression of mutant EGFR. | 2020-12-03 |
20200377894 | ENGINEERING OF ACETYL-CoA METABOLISM IN YEAST - The invention relates to engineering of acetyl-CoA metabolism in yeast and in particular to production of acetyl-CoA in a non-ethanol producing yeast lacking endogenous gene(s) encoding pyruvate decarboxylase and comprising a heterologous pathway for synthesis of cytosolic acetyl-CoA. | 2020-12-03 |
20200377895 | Use of constitutively active variants of growth factor receptors as selection markers for the generation of stable producer cell lines - The present invention relates to methods for the selection of a stable producer cell line expressing one or more protein(s) of interest (POIs), comprising the stable transfection of cells with a gene encoding a constitutively active variant of a growth factor receptor, respective methods for the expression of one or more POIs in such stable producer cell lines, and uses of a constitutively active variant of a growth factor receptor as selection marker in the cultivation of cells. | 2020-12-03 |
20200377896 | LUX EXPRESSION IN CELLS AND METHODS OF USE - Cells, including stem cells, comprising an autobioluminescent phenotype, wherein the cells emit a luminescent signal in the absence of an exogenous luminescent stimulator, are provided. The luminescent signal may be constitutive, inducible, repressible, or tissue-specific. The cells express a synthetically engineered bacterial luciferase (lux) cassette, i.e., the luxCDABEfrp gene cassette. The cells may comprise luxA, luxB, luxC, luxD, luxE, and flavin reductase. The cells may each express a combined expression level of luxC, luxD, luxE, and flavin reductase that is from ten to forty times greater than a combined expression level of luxA and luxB. Further, methods of making and using the cells comprising an autobioluminescent phenotype are disclosed herein. | 2020-12-03 |
20200377897 | REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY - The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest. | 2020-12-03 |
20200377898 | INTRON-CONTAINING PROMOTERS AND USES THEREOF - The present invention relates to the field of molecular biology and more particularly to promoters useful for metabolic engineering in yeast or fungi for the production of biobased chemicals with broad applications. Intron-containing promoters with strong activity during oil-accumulation stages are particularly useful for genetic engineering in yeast and fungi, particularly | 2020-12-03 |
20200377899 | METHODOLOGIES AND COMPOSITIONS FOR CREATING TARGETED RECOMBINATION AND BREAKING LINKAGE BETWEEN TRAITS - The current disclosure relates to methods and compositions for improving plant varieties through plant breeding and plant genetics. For instance, the disclosure concerns increasing the recombination frequency of a heterozygous trait genetically linked to a second trait within plants. Further, the disclosure concerns breaking the genetic linkage between a first allele and a second allele. | 2020-12-03 |
20200377900 | METHODS AND COMPOSITIONS FOR GENERATING DOMINANT ALLELES USING GENOME EDITING - The present disclosure provides methods and compositions for generating dominant alleles using targeted editing techniques. Also provided are modified chromosomes, cells, tissues, and plants comprising modified dominant allele. | 2020-12-03 |
20200377901 | METHOD FOR PRODUCING NATURAL RUBBER, TRANSGENIC PLANT, METHOD FOR PRODUCING PNEUMATIC TIRE, AND METHOD FOR PRODUCING RUBBER PRODUCT - To provide methods for producing a natural rubber which enable the production of a natural rubber with an increased molecular weight, and transgenic plants which are able to produce a natural rubber with an increased molecular weight. Included is a method for producing a natural rubber, the method including the steps of: introducing a gene coding for a cis-prenyltransferase (CPT) family protein derived from a rubber-producing plant A into a rubber-producing plant B to prepare a transgenic plant C; and producing a natural rubber using the transgenic plant C, the rubber-producing plant A producing a natural rubber having a higher molecular weight than a natural rubber produced by the rubber-producing plant B not transfected with the gene. | 2020-12-03 |
20200377902 | TRANSCRIPTION FACTORS THAT REGULATE NICOTINE BIOSYNTHESIS IN TOBACCO - The present invention provides nucleic acids encoding transcription factors and methods of using these nucleic acids to modulate nicotine production in plants and to produce plants having modulated nicotine production. | 2020-12-03 |
20200377903 | REGULATING LIGNIN BIOSYNTHESIS AND SUGAR RELEASE IN PLANTS - This disclosure provides genetically modified plants, plant cells and plant tissues that show modified lignin content and/or sugar release as compared to a wild type control plant which was not genetically modified. In addition, the disclosure provides methods of regulating lignin content and sugar release in a plant. The disclosure also provides methods of producing bioproducts using the genetically modified plants of the instant disclosure. | 2020-12-03 |
20200377904 | COMPOSITIONS AND METHODS FOR PRODUCING TOBACCO PLANTS AND PRODUCTS HAVING REDUCED OR ELIMINATED SUCKERS - The present disclosure provides methods and compositions for controlling sucker growth in tobacco by altering the expression of different target genes. | 2020-12-03 |
20200377905 | Herbicide-Resistant Brassica Plants and Methods of Use - The invention provides transgenic or non-transgenic plants with improved levels of tolerance to AHAS-inhibiting herbicides. The invention also provides nucleic acids encoding mutants of the acetohydroxyacid synthase (AHAS) large subunit, expression vectors, plants comprising the polynucleotides encoding the AHASL subunits containing single, double or more mutations, plants comprising one, two or more AHASL subunit single mutant polypeptides, methods for making and using the same, and methods of controlling weeds. | 2020-12-03 |
20200377906 | CODON-OPTIMIZED HUMAN NPC1 GENES FOR THE TREATMENT OF NIEMANN-PICK TYPE C1 DEFICIENCY AND RELATED CONDITIONS - The present disclosure provides compositions for viral gene therapy, e.g. Adeno-Associated virus-directed gene therapy, and methods of using the same for the treatment and/or prevention of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C. | 2020-12-03 |
20200377907 | GENE THERAPY TO IMPROVE VISION - The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signalling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased | 2020-12-03 |
20200377908 | PARAINFLUENZA VIRUS 5 BASED VACCINES - The present invention provides safe, stable, efficacious, and cost-effective vaccines based on viral expression vectors that include a parainfluenza virus 5 (PIV5) genome including a heterologous nucleotide sequence expressing a heterologous polypeptide. | 2020-12-03 |
20200377909 | DIRECTED GENOME ENGINEERING USING ENHANCED TARGETED EDITING TECHNOLOGIES - The present disclosure provides methods and compositions for enhancing targeted genome editing and engineering. | 2020-12-03 |
20200377910 | METHOD FOR INCREASING MUTATION INTRODUCTION EFFICIENCY IN GENOME SEQUENCE MODIFICATION TECHNIQUE, AND MOLECULAR COMPLEX TO BE USED THEREFOR - The present invention provides a method of modifying a targeted site of a double-stranded DNA, comprising a step of introducing a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double-stranded DNA and PmCDA1 are bonded, into a cell containing the double-stranded DNA, and culturing the cell at a low temperature at least temporarily to convert the targeted site, i.e., the target nucleotide sequence and nucleotides in the vicinity thereof, to other nucleotides, or delete the targeted site, or insert nucleotide into the site. | 2020-12-03 |
20200377911 | ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS - Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9-mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins. | 2020-12-03 |
20200377912 | OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION - The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity. | 2020-12-03 |
20200377913 | BIOSYNTHESIS OF METAL NANOPARTICLES - A method of preparing metal nanoparticles using a fungal extract includes providing an aqueous solution including a metal salt; and combining the fungal extract with the aqueous metal salt solution to produce the metal nanoparticles. The fungal extract can be an aqueous extract of the manglicolous fungi The metal salt can be copper sulfate (CuSO | 2020-12-03 |
20200377914 | EXTRACTION OF ALKANOIC ACIDS - The present invention relates to a method of extracting an alkanoic acid and/or ester there of from an aqueous medium, the method comprising: (a) contacting the alkanoic acid and/or ester thereof in the aqueous medium with at least one extracting medium for a time sufficient to extract the alkanoic acid and/or ester thereof from the aqueous medium into the extracting medium, (b) separating the extracting medium with the extracted alkanoic acid and/or ester thereof from the aqueous medium wherein the extracting medium comprises: -a mixture of at least one alkyl-phosphine oxide, preferably Trioctylphosphine oxide (TOPO), and at least one alkane wherein the alkane comprises at least 12 carbon atoms. | 2020-12-03 |
20200377915 | RECOMBINANT CORYNEBACTERIUM CAPABLE OF PRODUCING BILIVERDIN IX-alpha AND METHOD OF PRODUCING BILIVERDIN IX-alpha USING THE SAME - Disclosed are recombinant strain of a genus | 2020-12-03 |
20200377916 | GLYCOLIPID COMPOSITIONS AND METHODS THEREOF - The present disclosure relates to glycolipid compositions, methods for making glycolipid compositions, and their uses thereof. Glycolipid compositions can be prepared via yeast-mediated catalyzed reaction, and exhibit excellent surfactant properties having high corrosion inhibition performance, good reducing surface tension efficiency. Processes of the present disclosure can provide glycolipid compositions having one or more of: a ratio of lactonic glycolipids to glycolipid acylic esters is from about 1:10 to about 10:1, a molecular weight of from about 400 g/mol to about 10,000 g/mol, a corrosion rate of carbon steel from about 0.5 MPY to about 100 MPY at room temperature and at pH 4-6. Furthermore, aqueous solutions of the glycolipid compositions of the present disclosure can have a surface tension of from about 20 mN/m to about 80 mN/m. | 2020-12-03 |
20200377917 | IMP-PRODUCING MICROORGANISM AND METHOD OF PRODUCING IMP USING THE SAME - The present disclosure relates to a microorganism of the genus | 2020-12-03 |
20200377918 | PERFUSION MEDIUM - The invention relates to a method of culturing mammalian cells expressing a heterologous protein in a perfusion cell culture comprising adding iron and a retinoid to reduce wasteful cell bleed during production phase. The invention further relates to a serum-free perfusion medium comprising iron and a retinoid and its use for culturing cells in a perfusion culture during production phase or for reducing the cell bleed volume during production phase. | 2020-12-03 |
20200377919 | DECREASING LACTATE LEVEL AND INCREASING POLYPEPTIDE PRODUCTION BY DOWNREGULATING THE EXPRESSION OF LACTATE DEHYDROGENASE AND PYRUVATE DEHYDROGENASE KINASE - The present invention provides ethods and compositions for reducing lactate production and increasing polypeptide production in cultured cells. In one aspect, the invention provides a method comprising culturing cells expressing a) a small interfering RNA (siRNA) specific for a lactate dehydrogenase (LDH) and b) an siRNA specific for a pyruvate dehydrogenase kinase (PDHK). In another aspect, the invention provides cultured cells or vectors comprising an siRNA specific for a LDH and an siRNA specific for a PDHK. | 2020-12-03 |
20200377920 | METHOD AND COMPOSITION FOR BIOCATALYTIC PROTEIN-OLIGONUCLEOTIDE CONJUGATION AND PROTEIN-OLIGONUCLEOTIDE CONJUGATE - A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferse catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferse catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferse catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand. | 2020-12-03 |
20200377921 | Methods for Producing Polypeptides in Protease-Deficient Mutants of Trichoderma - The present invention relates to mutants of a parent | 2020-12-03 |
20200377922 | METHOD FOR MODIFYING MICROCYSTINS AND NODULARINS - A method is used for producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), including the steps of a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, b) adding one or more modified substrates, preferably modified amino acids to said culture, and c) inoculating the non-ribosomal peptide, producing strain the presence of said modified substrates. The thus modified non-ribosomal peptide may be used for the therapy of various diseases. | 2020-12-03 |
20200377923 | METHOD FOR PRODUCING FERMENTATION PRODUCT - To provide a method for efficiently utilizing bacterial cells and unused raw materials for culture in the manufacture of fermentation products. | 2020-12-03 |
20200377924 | LOW CROSS-LINKING GELATINE - The present invention relates to a process for the preparation of a gelatine blend comprising the steps of a) providing a gelatine extract or a series of gelatine extracts, differing in bloom and viscosity; b) subjecting a portion of one or more of the gelatine extracts of a) to an enzymatic treatment to obtain one or more enzymatically treated extracts having a viscosity that is lower than that of the respective extract before said enzymatic treatment, while maintaining the bloom substantially unaffected, the enzymatically treated extracts comprising less than 1.5 w/w % of gelatine-derived peptides having a molecular weight of less than 2000 Da; c) selecting one or more gelatine extracts of step a); d) combine the selected one or more gelatine extracts of step c) and blend with one or more enzymatically treated extracts of step b) to provide a gelatine composition having a lower viscosity as compared to that of the said combined selected extracts of step c) without being blended with said selected one or more enzymatically treated gelatine extracts of step b), while maintaining the bloom substantially unaffected. The present invention also relates to a gelatine composition, and a gelatine product comprising said gelatine composition. | 2020-12-03 |
20200377925 | TESTER PAPER AND METHODS OF USE THEREOF FOR DETECTING A BACTERIAL INFECTION - In various embodiments, the present disclosure provides testers for detecting a bacterial infection and methods of production and uses thereof. | 2020-12-03 |
20200377926 | HYBRIDIZATION CHAIN REACTION-BASED METHOD FOR AMPLIFYING IMMUNOSIGNALS - The invention provides an antibody-based bioanalytical method, specifically a hybridization Chain Reaction-based Method for Amplifying Immunosignals named immunosignal HCR (isHCR), which combines antibody-antigen interactions with hybridization Chain Reaction (HCR) technology for amplifying immunosignals. The invention also provides a kit for performing the above isHCR. | 2020-12-03 |
20200377927 | A Collector Device of Environmental Exposure for Biotic and Abiotic Agents - A collector device of environmental exposure is provided. This device may be used to collect and, after technical upgrade, monitor environmental exposure in personal and stationary settings. By coupling with advanced genomic analysis and chemical analysis technologies, the device and its accompanying methodology are capable of detecting environmental agents of diverse nature, many of which could pose health risks if going unaware of or uncontrolled. This type of information provides much needed clues to reconstruct and pinpoint the course of disease etiology at both personal and epidemic scales. By combining personal exposome and personal omics analyses, we can recapitulate with the intention to then prescribe treatment plans with unprecedented precision. | 2020-12-03 |
20200377928 | METHOD OF DETECTING MINOR BCR-ABL1 GENE - The disclosure provides a method comprising (1) conducting a PCR using a nucleic acid sample obtained from the subject as the template, a forward primer having a nucleic acid sequence of a part of exon 1 of the BCR gene, and a reverse primer having a nucleic acid sequence complementary to a part of exons 2 to 11 of the ABL1 gene, in the presence of a modified nucleic acid having a nucleic acid sequence of a part of exons 2 to 14 of the BCR gene or a nucleic acid sequence complementary thereto; and (2) determining that the subject has the minor BCR-ABL1 gene when the nucleic acid amplification is occurred in the PCR. | 2020-12-03 |
20200377929 | PEPTIDE NUCLEIC ACID FUNCTIONALIZED HYDROGEL MICRONEEDLES FOR SAMPLING AND DETECTION OF INTERSTITIAL FLUID NUCLEIC ACIDS - The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin. | 2020-12-03 |
20200377930 | METHODS AND KITS FOR DETERMINING THE EFFICIENCY OF PLASMA SEPARATION FROM WHOLE BLOOD - Methods and kits for determining the efficiency of plasma separation from whole blood are provided, using real-time PCR amplification of two amplicons, namely, a short amplicon of e.g. 70-150 bps and a long amplicon of e.g. 350-600 bps. The separation efficiency is determined based on the difference in amplification patterns of the two amplicons. | 2020-12-03 |
20200377931 | DNA CHIP FOR DETECTING DENTAL CARIES BACTERIA - Provided is a means/method with which it is possible to quickly and efficiently detect bacteria that cause dental caries and evaluate dental caries. The present invention pertains to a DNA chip, etc., that carries, for example, the following probe (a) and at least one probe from among the following probes (b) and (c). (a) A probe comprising a nucleic acid that hybridizes to 16S rRNA specific to each of one or more oral bacteria to be detected, wherein the probe is any of the following sequences (i)-(iii): (i) at least one sequence selected from nucleotide sequences represented by SEQ ID NOS: 2-7; (ii) a complementary sequence of a sequence of (i); or (iii) a sequence substantially identical to a sequence of (i) or (ii). (b) A total amount indicator probe. (c) An absolute amount indicator probe of one type or a plurality of types. | 2020-12-03 |
20200377932 | DDX24 MUTATIONS AND USE THEREOF - Provided are DDX24 mutations and the use thereof, wherein the mutations include Glu271Lys, Lys11Glu and Arg436His. The mutations, i.e. Glu271Lys, Lys11Glu and Arg436His, of DDX24 gene are significantly associated with the development of blood vessels. It would result in vascular malformations by interfering with DDX24. In addition, the onset of human vascular malformations can be predicted by detecting the SNP sites of DDX24. | 2020-12-03 |
20200377933 | MOLECULAR DETECTION USING LIGATION AMPLIFICATION - Disclosed herein are compositions, kits, methods, and systems for detecting a target molecule in a sample using a detection molecule. | 2020-12-03 |
20200377934 | METHOD FOR DIRECT QUANTIFICATION OF NUCLEIC ACIDS IN REAL TIME qPCR - A method for direct quantification of nucleic acids in real time qPCR. The invention discloses a method for specific quantification of nucleic acids in real time qPCR. The disclosed invention can be achieved in three ways; 1) using a modified primer for qPCR quantification; 2) using strand displacement based probes for qPCR quantification; 3) using label-free endonuclease probe for qPCR quantification. The mechanism of quantification is based on the fact that, DNA, RNA or modified oligonucleotide based light-up dye-aptamer system, where dye is not fluorescent in free state but its fluorescence increases multi-fold when it binds to its specific aptamer. | 2020-12-03 |
20200377935 | POLYNUCLEOTIDE ADAPTERS AND METHODS OF USE THEREOF - Provided are methods and compositions for reducing unfavorable dimer formation and thereby improving library preparation, e.g., for sequencing. Compositions and methods include adapters comprising extensive 5′ overhang sequences and blunt end or T overhang 3′ sequences to ends of target nucleic acid(s) to facilitate amplification and analysis of such sequences. | 2020-12-03 |
20200377936 | METHODS AND COMPOSITIONS FOR GENERATING REFERENCE MAPS FOR NANOPORE-BASED POLYMER ANALYSIS - The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference sequence through a nanopore to generate a plurality of reference output signals, wherein each possible multi-subunit sequence that can determine an output signal appears only once in the reference sequence. The output signals are compiled into a reference map for nanopore analysis of an analyte polymer. Also provided are methods and compositions for calibrating the nanopore system for optimized polymer analysis. | 2020-12-03 |
20200377937 | FAST-FORWARD SEQUENCING BY SYNTHESIS METHODS - Described herein are methods of generating a coupled sequencing read pair for a polynucleotide, and methods of analyzing the coupled sequencing read pair. The coupled sequencing read pair can be analyzed to detect polynucleotide variants, including at loci that are not directly sequenced within the coupled sequencing read pair. Other analytical methods can include using coupled sequencing read pairs to construct or validate a consensus sequence. The coupled sequencing read pair may be generated for a polynucleotide by generating sequencing data for a first region by extending a primer using labeled nucleotides; further extending the primer through a second region using nucleotides provided in a second region flow order, wherein primer extension through the second region is faster than primer extension through the first region; and generating sequencing data associated with a sequence of a third region of the polynucleotide by further extending the primer using labeled nucleotides. | 2020-12-03 |
20200377938 | METHODS AND SYSTEMS FOR ANALYZING IMAGE DATA - Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies. | 2020-12-03 |
20200377939 | FABRICATION OF NANOCHANNEL WITH INTEGRATED ELECTRODES FOR DNA SEQUENCING USING TUNNELING CURRENT - A DNA sequencing device and related methods, wherein the device includes a substrate, a nanochannel formed in the substrate, a first electrode positioned on a first side of the nanochannel, and a second electrode. The second electrode is positioned on a second side of the nanochannel opposite the first electrode and is spaced apart from the first electrode to form an electrode gap that is exposed in the nanochannel. At least a portion of first electrode is movable relative to the second electrode to decrease a size of the electrode gap. | 2020-12-03 |
20200377940 | ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME - Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate. | 2020-12-03 |
20200377941 | CORRECTING FOR DEAMINATION-INDUCED SEQUENCE ERRORS - Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease. However, the value of such information can be compromised by errors introduced by or before the sequencing process including preparing nucleic acids for sequencing. Blunting single-stranded overhangs on nucleic acids in a sample can introduce deamination-induced sequencing errors. The disclosure provides methods of identifying and correcting for such deamination-induced sequencing errors and distinguishing them from real sequence variations. | 2020-12-03 |
20200377942 | METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES - The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. | 2020-12-03 |
20200377943 | FLEXIBLE AND HIGH-THROUGHPUT SEQUENCING OF TARGETED GENOMIC REGIONS - The disclosure pertains to materials and methods for capturing a target genomic region, comprising hybridizing an extension probe and a ligation probe to target sequences that flank the target genomic region; elongating the 3′ end of the extension probe until the 3′ end of the elongated extension probe is adjacent to the 5′ end of the ligation probe; and ligating the 3′ end of the elongated extension probe with the 5′ end of the ligation probe to produce a ligated probe. The ligated probe can be PCR amplified to produce copies of the target genomic region that can be detected or sequenced. Certain embodiments of the invention also provide methods of producing double stranded probes suitable for capturing and analyzing both strands of a target genomic region in a double stranded genomic DNA. The invention also provides kits for performing the methods disclosed herein. | 2020-12-03 |
20200377944 | COMPOSITIONS AND METHODS FOR UNIDIRECTIONAL NUCLEIC ACID SEQUENCING - This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide. | 2020-12-03 |
20200377945 | BIOMARKERS FOR TYPE 2 DIABETES MELLITUS AND USE THEREOF - The present invention provides a method for assessing the presence or the risk of development of type 2 diabetes mellitus in a subject based on abundance data of several CAGs. Also provided is a method for evaluating efficacy of diet intervention or disease treatment in a subject having type 2 diabetes mellitus based on abundance data of these CAGs. | 2020-12-03 |
20200377946 | Selective Reduction of Allelic Variants - Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD). | 2020-12-03 |
20200377947 | METHOD FOR EXAMINING LONG-TERM PROGNOSIS OF ACUTE CORONARY SYNDROME AND DIAGNOSTIC KIT - A diagnostic method according to an embodiment of the present invention is to determine prognosis, such as recurrence and death, which commonly occurs after acute coronary syndrome. A method of determining long-term prognosis of acute coronary syndrome includes analyzing anxiety and serotonin transporter gene polymorphism associated therewith. The method is capable of determining the risk of incidence of major adverse cardiac events including recurrence and/or death after acute coronary syndrome. | 2020-12-03 |
20200377948 | USE OF ADIPOQ GENE EXPRESSION LEVEL FOR CLASSIFICATION OF A SUBJECT IN RISK GROUPS IN THE PROGNOSIS OR DIAGNOSIS OF TYPE II DIABETES MELLITUS - The invention relates to the use of the relative value of the gene expression level of the gene for ADIPOQ and/or of a gene, the expression of which has linear statistical correlation with that of the ADIPOQ gene, in the prognosis or the diagnosis of a type II diabetes mellitus disease in a test subject. It further relates to a method for prognosing and/or diagnosing a type II diabetes mellitus disease for classification of a subject into risk groups, wherein the gene expression level of the ADIPOQ gene and/or of a gene, the expression of which has linear statistical correlation with that of the ADIPOQ gene, is determined and the subject is subsequently classified into risk groups, taking said gene expression level into account. | 2020-12-03 |
20200377949 | USE OF THE IL-6 GENE EXPRESSION LEVEL FOR CLASSIFICATION OF A SUBJECT IN RISK GROUPS IN THE PROGNOSIS OR DIAGNOSIS OF TYPE II DIABETES MELLITUS - The invention relates to the use of the relative value of the gene expression level of the IL-6 gene in the prognosis or the diagnosis of a type II diabetes mellitus disease in a subject. It further relates to a method for prognosing and/or diagnosing a type II diabetes mellitus disease for classification of a subject into risk groups, wherein the gene expression level of the IL-6 gene is determined and the subject is subsequently classified into risk groups, taking said gene expression level into account. | 2020-12-03 |
20200377950 | GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF - The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection. | 2020-12-03 |
20200377951 | FRATAXIN-SENSITIVE MARKERS FOR DETERMINING EFFECTIVENESS OF FRATAXIN REPLACEMENT THERAPY - The present disclosure is based, at least in part, on providing a set of markers, also referred to herein as FXN-sensitive genomic markers (or FSGMs), the respective expression levels of which are positively or negatively correlated to frataxin (FXN) levels in a cell. Therefore, these FSGMs can be used to determine, evaluate, and/or monitor the effectiveness of FXN replacement therapy in a subject. | 2020-12-03 |
20200377952 | COMPOSITIONS AND METHODS FOR XI CHROMOSOME REACTIVATION - In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases. | 2020-12-03 |
20200377953 | THERAPEUTIC AND DIAGNOSTIC METHODS FOR MAST CELL-MEDIATED INFLAMMATORY DISEASES - The present invention features, inter alia, methods of treating patients having a mast cell-mediated inflammatory disease, methods of determining whether patients having a mast cell-mediated inflammatory disease are likely to respond to a therapy (e.g., a therapy comprising an agent selected from the group consisting of a tryptase antagonist, an Fc epsilon receptor (FcεR) antagonist, an IgE | 2020-12-03 |
20200377954 | DETECTION OF COLORECTAL CANCER - The present disclosure provides, among other things, methods for colorectal cancer screening and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include screening methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR. | 2020-12-03 |
20200377955 | USE OF CELL-FREE CIRCULATING RNA (cfRNA) EXPRESSION OF PD-L1 AND ERCC1 IN PLASMA TO MONITOR RESPONSE TO THERAPY IN NSCLC - Quantitative levels of ERCC1 cfRNA are used to monitor/predict a clinical response with respect to a disease state of a cancer in a patient subject to treatment with a platinum-based drug. Most typically, the cancer is a NSCLC and the patient is treated with a platinum-based drug. Where treatment also includes immune checkpoint inhibitors, PD-L1 cfRNA may be quantified to further predict treatment outcome. | 2020-12-03 |
20200377956 | METHODS AND MATERIALS FOR ASSESSING AND TREATING CANCER - Provided herein are methods and materials for detecting and/or treating subject (e.g. a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g. a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human). | 2020-12-03 |
20200377957 | MULTIGENE PROGNOSTIC ASSAY FOR LUNG CANCER - The present invention provides methods for providing a prognosis for lung adenocarcinoma, using a panel of eight molecular markers that are differentially expressed in lung adenocarcinoma. | 2020-12-03 |
20200377958 | BIOMARKERS AND METHODS FOR TREATMENT WITH NAE INHIBITORS - Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers corresponding to the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment. | 2020-12-03 |
20200377959 | DETECTION OF COLORECTAL CANCER - The present disclosure provides, among other things, methods for colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for colorectal cancer detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for colorectal cancer screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR. | 2020-12-03 |
20200377960 | METHODS OF DETECTING TUMOR PROGRESSION VIA ANALYSIS OF CELL-FREE NUCLEIC ACIDS - The present disclosure provides methods of assessing tumor progression in a subject. In an aspect, a method for assessing tumor progression of a subject can comprise: measuring a count of a plurality of cell-free DNA (cfDNA) molecules at each of a plurality of genomic regions, wherein the plurality of cfDNA molecules is obtained or derived from a bodily fluid sample of the subject; processing the counts measured at each of the genomic regions to obtain quantitative measures of deviation of the counts relative to a plurality of reference values, to produce deviation scores; determining a difference between the deviation scores and a plurality of reference deviation scores to produce changes in deviation (CID) values, and calculating a CID score based on the CID values; and detecting a tumor progression of the subject when the CID score satisfies a pre-determined criterion. | 2020-12-03 |
20200377961 | BIFIDOBACTERIUM LONGUM - The multiple embodiments described herein comprise the genome of a probiotic | 2020-12-03 |
20200377962 | Device for Continuously Producing Sugar by Hydrolyzation Using Lignocellulosic Raw Material - The present utility model provides a device for continuously producing sugar by hydrolyzation using a lignocellulosic raw material. The device comprises: an acid solution output unit, a raw material mixing unit, a feeding unit, a main reaction unit, and a discharging unit. The device is a genuine continuous hydrolyzation sugar-producing device, which can achieve continuous feeding, continuous reaction, and continuous discharging in terms of time, and can effectively reduce labor intensity, increase production efficiency, and increase sugar yields and sugar concentrations. | 2020-12-03 |
20200377963 | PLATED STEEL SHEET HAVING EXCELLENT SURFACE QUALITY, STRENGTH AND DUCTILITY - Disclosed are: a plated steel sheet having a plating film on a surface of a hot-rolled steel sheet; and a method for manufacturing the same, wherein the hot-rolled steel sheet comprises, by weight, 0.15 to 0.25% of C, 0.5% or less of Si, 0.5 to 2.0% of Mn, 0.03% or less of P, 0.015% or less of S, 0.05% or less of Al, 0.01% or less of N, 0.05% or less of Ti (excluding 0%), 0.01% or less of B (excluding 0%), a balance of Fe, and inevitable, impurities, satisfies the following relationship 1, and comprises, by area, 10 to 30% of ferrite, 20 to 40% of pearlite, and 35 to 55% of bainite, as a microstructure: | 2020-12-03 |
20200377964 | METHOD FOR PRODUCING HOT-DIP GALVANIZED STEEL SHEET AND CONTINUOUS HOT-DIP GALVANIZING APPARATUS - A method for producing a hot-dip galvanized steel sheet includes supplying humidified gas to the soaking zone | 2020-12-03 |
20200377965 | METHOD FOR MANUFACTURING HIGH-CARBON BEARING STEEL AND HIGH-CARBON BEARING STEEL MANUFACTURED THEREFROM - Disclosed is a method for manufacturing high-carbon bearing steel, which include: heating a billet at a temperature of about 950 to 1,050° C. for about 70 to 120 minutes, rolling the billet to manufacture a wire rod, winding the wire rod to manufacture a wire rod coil, cooling the wire rod coil, and subsequently heat treating the wire rod coil for spheroidizing and carbonitriding, respectively. The bearing steel may include an amount of about 0.9 to 1.3 wt % of carbon (C), an amount of about 1.1 to 1.6 wt % of silicon (Si), an amount of about 1.0 to 1.5 wt % of manganese (Mn), an amount of about 1.5 to 1.9 wt % of chromium (Cr), an amount of about 0.2 to 0.6 wt % of nickel (Ni), an amount of about 0.1 to 0.3 wt % of molybdenum (Mo), and the balance iron (Fe) based on the total weight thereof. | 2020-12-03 |
20200377966 | HEATING DEVICE AND CORRESPONDING APPARATUS AND METHOD - A heating device and/or method to heat a slab, and in particular its edges, by electromagnetic induction, comprising including an electric coil and a magnetic concentrator associated with the electric coil. | 2020-12-03 |
20200377967 | STEEL MATERIAL COOLING DEVICE AND COOLING METHOD - A device to cool a steel material having undergone hot rolling mills, the device including: a conveying mechanism which conveys the steel material while accelerating the steel material; a water cooling mechanism which cools the steel material while the conveying mechanism conveys the steel material; and a control unit which controls the conveying mechanism and the water cooling mechanism to cause the cooling of the steel material to satisfy Formula (1) below, wherein a water cooling time decrease rate γ in Formula (1) below is decided based on a length of a water cooling zone where the water cooling mechanism is provided and a time Δt | 2020-12-03 |
20200377968 | COPPER PRECIPITATION METHOD BY IRON MODIFICATION AND COPPER PRECIPITATION AND PREPARATION APPARATUS USED THEREFOR - The present disclosure provides a copper extraction method via iron modification and a copper extraction apparatus to perform the method. The method involves adding iron to an acidic solution in an reactor and oxidizing the iron. The method includes adding a copper-containing acidic solution and adding hydrogen as a reaction promoter into the reactor. Thus, the method may artificially modify the iron element to a copper element. Thus, the iron is used to extract a large amount of copper. This method may be as economical as copper mining. | 2020-12-03 |
20200377969 | CARBOTHERMIC DIRECT REDUCTION OF CHROMITE USING A CATALYST FOR THE PRODUCTION OF FERROCHROME ALLOY - A direct reduction process for the production of ferrochrome from chromite ore or concentrate is disclosed. According to the present invention, calcium chloride (CaCl | 2020-12-03 |
20200377970 | METHOD FOR RECOVERING PRECIOUS METALS FROM THIOSULFATE LEACH SOLUTIONS - The present disclosure is directed to a process for thiosulfate leaching of a precious metal-containing material and recovering a precious metal from a pregnant leach solution using a resin extractant. The precious metal is eluted from the loaded resin optionally using an eluant comprising trithionate. Various process improvements include maintaining the thiosulfate-containing leach solution substantially free of thiols and amines, maintaining a concentration of a sulfide in the thiosulfate leach solution of no more than about 100 ppm, recycling the barren resin free of contact with a sulfide, bisulfide, and polysulfide, and/or maintaining a concentration of tetrathionates, trithionates, sulfur-oxygen anions, and/or combinations thereof within about 50% of a concentration level of the one or more of tetrathionates, trithionates, sulfur-oxygen anions, the combinations thereof in the precious metal-containing solution before contact with the recycled barren resin. | 2020-12-03 |
20200377971 | METHOD FOR PREPARING LEAD DIRECTLY FROM LEAD-CONTAINING MATERIAL BY SOLID PHASE REACTION - A method for preparing lead directly from a lead-containing material by a solid phase reaction, includes: step 1, adding the lead-containing material to be processed to the grinder, and adding a metal substance and water to the grinder, wherein an activity of the metal substance is larger than that of lead; the solid phase reaction between the lead-containing material and the metal substance is caused directly by the grinder through a mechanical force to obtain a reaction product; step 2, washing and filtering the reaction product to obtain the lead and a metal salt solution corresponding to the metal substance; step 3, performing a melt casting on the lead to obtain a crude lead, crystallizing the metal salt solution to obtain a metal salt corresponding to the metal substance. | 2020-12-03 |
20200377972 | METHOD FOR PRODUCING TI-AL ALLOY - A method includes the production of a primary ingot, the production of a secondary ingot, and the removal of a flux layer. A CaO—CaF | 2020-12-03 |
20200377973 | METAL POROUS BODY - A metal porous body having a three-dimensional network structure, includes: a framework forming the three-dimensional network structure; and a coating layer having fine pores and coating the framework, the three-dimensional network structure including a rib and a node connecting a plurality of ribs, the framework including an alkali-resistant first metal, the fine pores having an average fine pore diameter of 10 nm or more and 1 μm or less, the coating layer including an alkali-resistant second metal and optionally including an alkali-soluble metal, the alkali-soluble metal being contained at a proportion of 0% by mass or more and 30% by mass or less with reference to a total mass of the framework and the coating layer. | 2020-12-03 |
20200377974 | NICKEL-BASE ALLOY WELDING MATERIAL, WELDING MATERIAL FOR NUCLEAR REACTOR, NUCLEAR POWER APPARATUS AND NUCLEAR POWER STRUCTURE, AND METHOD OF REPAIRING NUCLEAR POWER APPARATUS AND NUCLEAR POWER STRUCTURE - A nickel-base alloy welding material according to an embodiment comprises: Cr (chromium) larger than 30.0% and less than or equal to 36.0% by mass; C (carbon) less than or equal to 0.050% by mass; Fe (iron) larger than or equal to 1.00% and less than or equal to 3.00% by mass; Si (silicon) less than or equal to 0.50% by mass; Nb (niobium)+Ta (tantalum) less than or equal to 3.00% by mass; Ti (titanium) less than or equal to 0.70% by mass; Mn (manganese) larger than or equal to 0.10% and less than or equal to 3.50% by mass; Cu (copper) less than or equal to 0.5% by mass, and a remainder is Ni and unavoidable impurities. | 2020-12-03 |
20200377975 | PARTICLE-REINFORCED ALUMINUM COMPOSITE MATERIAL, PRESSURE-RESISTANT COMPONENT USING SAME, AND METHOD FOR MANUFACTURING PRESSURE-RESISTANT COMPONENT - A particle-reinforced aluminum composite material includes: a base material formed of an aluminum alloy; and reinforcing particles dispersed in the base material. The reinforcing particles include a main component represented by MgAl | 2020-12-03 |
20200377976 | ULTRA-HIGH STRENGTH ALUMINUM ALLOY PRODUCTS AND METHODS OF MAKING THE SAME - Provided herein are ultra-high strength aluminum alloys and products prepared therefrom, along with methods of processing the ultra-high strength aluminum alloys. The aluminum alloys described herein are high solute alloys, including significant amounts of zinc (Zn), magnesium (Mg), copper (Cu), and other elements in addition to aluminum. The aluminum alloys described herein are amenable to post-aging processing without cracking. | 2020-12-03 |
20200377977 | METHOD FOR PRODUCING ALLOY STEEL - Provided is a method for producing steel including: preparing a first molten steel and a manganese-containing melt; supplying a nitrogen gas into a storage to blow nitrogen into the melt received in the storage and thereby adjusting a nitrogen content (wt %) in the melt to a required nitrogen content (wt %); and mixing the melt and the first molten steel to produce a second molten steel containing manganese and nitrogen. Since nitrogen is not blown while melting large amounts of solid materials, the oxidation of manganese due to a high temperature may be minimized or prevented. In addition, a large amount of solid material is not added, and a small amount of manganese-containing nonferrous metal or a FeMn ferroalloy is added, if necessary, into a produced melt in a molten state, and thus, a problem of temperature drop due to the input of the solid material may be minimized or prevented. | 2020-12-03 |
20200377978 | HIGH-STRENGTH GALVANIZED STEEL SHEET AND METHOD FOR MANUFACTURING SAME - A high-strength galvanized steel sheet includes a steel sheet having a steel composition having a specific component composition, a steel structure containing martensite and bainite at more than or equal to 70% (including 100%), ferrite at less than 20% (including 0%), and retained austenite at less than 5% (including 0%) in terms of area ratio, the amount of diffusible hydrogen in steel being less than or equal to 0.20 mass ppm; and a galvanizing layer provided on a surface of the steel sheet, having a content amount of Fe of 8 to 15% in mass %, and having an coating weight per one surface of 20 to 120 g/m | 2020-12-03 |
20200377979 | PRODUCTION OF HIC-RESISTANT PRESSURE VESSEL GRADE PLATES USING A LOW-CARBON COMPOSITION - A lower carbon steel alloy with specific substitutional alloying additions. The alloy is useful in the production of ASTM A516 grade pressure vessel steel plates with excellent HIC resistance. The material has a ferrite-pearlite microstructure, in normalized and stress relieved condition, appropriate for resisting hydrogen induced cracking, with isolated ferrite and pearlite constituents and no continuous pearlite bands. The material exhibits significant low temperature toughness. | 2020-12-03 |
20200377980 | HOT-ROLLED AND ANNEALED FERRITIC STAINLESS STEEL SHEET AND METHOD FOR MANUFACTURING THE SAME - Provided is a hot-rolled and annealed ferritic stainless steel sheet excellent in surface quality after bending work has been performed. | 2020-12-03 |
20200377981 | FE-BASED AMORPHOUS ALLOY RIBBON FOR FE- BASED NANOCRYSTALLINE ALLOY, AND METHOD FOR MANUFACTURING THE SAME - One embodiment of the present invention provides an Fe-based amorphous alloy ribbon for an Fe-based nanocrystalline alloy, the Fe-based amorphous alloy ribbon being a cooled body of a molten metal that has been applied to a surface of a chill roll, wherein the Fe-based amorphous alloy ribbon includes a recess having a depth of 1 μm or more in a 0.647 mm×0.647 mm region located in a central part, in the ribbon width direction, of a ribbon surface, which is a cooled surface, in which a maximum area of the recess having a depth of 1 μm or more is 3000 μm | 2020-12-03 |
20200377982 | SOFT MAGNETIC ALLOY AND MAGNETIC COMPONENT - Provided is a soft magnetic alloy which has high saturation flux density, low coercivity, and a high specific resistance, and is represented by the compositional formula (Fe | 2020-12-03 |
20200377983 | HYDRIDE-COATED MICROPARTICLES AND METHODS FOR MAKING THE SAME - A metal microparticle coated with metal hydride nanoparticles is disclosed. Some variations provide a material comprising a plurality of microparticles (1 micron to 1 millimeter) containing a metal or metal alloy and coated with a plurality of nanoparticles (less than 1 micron) containing a metal hydride or metal alloy hydride. The invention eliminates non-uniform distribution of sintering aids by attaching them directly to the surface of the microparticles. No method is previously known to exist which can assemble nanoparticle metal hydrides onto the surface of a metal microparticle. Some variations provide a solid article comprising a material with a metal or metal alloy microparticles coated with metal hydride or metal alloy hydride nanoparticles, wherein the nanoparticles form continuous or periodic inclusions at or near grain boundaries within the microparticles. | 2020-12-03 |
20200377984 | ALUMINUM ALLOY SUBSTRATE FOR MAGNETIC DISKS, METHOD FOR PRODUCING SAME, AND MAGNETIC DISK USING THIS ALUMINUM ALLOY SUBSTRATE FOR MAGNETIC DISKS - Provided are: an aluminum alloy substrate for a magnetic disk, including an aluminum alloy including 0.4 to 3.0 mass % of Fe with the balance of Al and unavoidable impurities; a method for producing the aluminum alloy substrate for a magnetic disk; and a magnetic disk in which an electroless Ni—P plating treatment layer and a magnetic layer formed thereon are disposed on a surface of the aluminum alloy substrate for a magnetic disk. | 2020-12-03 |
20200377985 | Method of manufacturing a wear-resistant aluminium alloy plate product - A method of manufacturing a rolled wear-resistant aluminium alloy product including the steps of: (a) providing a rolling feedstock material of an aluminium alloy having Mg 4.20% to 5.5%, Mn 0.50% to 1.1%, Fe up to 0.40%, Si up to 0.30%, Cu up to 0.20%, Cr up to 0.25%, Zr up to 0.25%, Zn up to 0.30%, Ti up to 0.25%, unavoidable impurities and balance aluminium; (b) heating the rolling feedstock; (c) hot-rolling of the feedstock to an intermediate gauge in a range of 15 mm to 40 mm; (d) hot-rolling of the feedstock from intermediate gauge to a final gauge in a range of 3 mm to 15 mm and wherein the hot-mill exit temperature is in a range of 130-285° C.; (e) cooling of the hot-rolled feedstock to ambient temperature. | 2020-12-03 |
20200377986 | METHOD FOR PRODUCING COPPER-TITANIUM BASED COPPER ALLOY MATERIAL FOR AUTOMOBILE AND ELECTRONIC PARTS AND COPPER ALLOY MATERIAL PRODUCED THEREFROM - The present invention relates to a production method of a copper-titanium (Cu—Ti)-based copper alloy material and a copper alloy material produced therefrom. Thus, the copper alloy material has target yield strength, electrical conductivity, and bending workability and thus is applied to automobiles and electric/electronic parts requiring high performance. | 2020-12-03 |
20200377987 | METHOD FOR MANUFACTURING SUPER-REFRACTORY NICKEL-BASED ALLOY AND SUPER-REFRACTORY NICKEL-BASED ALLOY - A method for manufacturing a super-refractory nickel-based alloy with a constituent composition such that the gamma-prime average precipitation quantity at 700° C. is at least 35 mol % includes a preparation step in which a material with a crystal grain diameter of 200 μm or less is manufactured by hot extrusion and a processing step in which this material is subjected to cold plastic processing with a processing rate of at least 30%. The cold plastic processing can be performed a plurality of times with a cumulative processing rate of at least 30%, and heat treatment is not performed between instances of cold plastic processing. The super-refractory nickel-based alloy can have a linear organization of a gamma phase and a gamma-prime phase or can include a carbide aggregated in an isometric crystal organization that includes a gamma phase and a gamma-prime phase. | 2020-12-03 |
20200377988 | METHOD FOR HEATING BLANK FOR ROLLING PRODUCTION - A method for heating a blank in a first heating furnace and a second heating furnace. The first heating furnace includes a first chamber and a second chamber communicating with the first chamber. The method includes: 1) heating the blank in the first chamber to the temperature of less than 300° C.; 2) transferring the blank heated in the first chamber to the second heating furnace, and heating the blank to the temperature of between 350° C. and 850° C., where the temperature of the second heating furnace is detected using a thermocouple, and the temperature of the blank is detected by an optical thermometer; 3) transferring the blank heated in the second heating furnace to the second chamber, and measuring the temperature of the blank using a contact thermometer; and 4) transferring the blank from 3) to a rolling mill. | 2020-12-03 |
20200377989 | ALLOY-PLATED STEEL MATERIAL HAVING EXCELLENT CORROSION RESISTANCE AND HIGH SURFACE QUALITY, AND METHOD FOR MANUFACTURING SAME - Provided is an alloy-plated steel material that can be used in home appliances, automobiles, and construction materials and the like and, more particularly, to an alloy-plated steel material having excellent corrosion resistance and high surface quality. | 2020-12-03 |
20200377990 | POST DEPOSITION HEAT TREATMENT OF COATING ON CERAMIC OR CERAMIC MATRIX COMPOSITE SUBSTRATE - In one example, a method for forming an environmental barrier coating (EBC) and/or abradable coating on a substrate. The method may include depositing a coating on a ceramic or ceramic matrix composite (CMC) substrate to form an as-deposited coating, wherein the coating includes at least one of an environmental barrier coating (EBC) and an abradable coating. The method further comprises heat treating the as-deposited coating at or above a first temperature for a first period of time following the deposition of the as-deposited coating on the substrate, wherein heat treating the as-deposited coating includes heating the as-deposited coating to or above the first temperature at a controlled rate. The heat treatment may be configured to at least one of decrease the open pores and/or microcracks of the heat-treated coating compared to the as-deposited coating or control a grain size of the heat-treated coating. | 2020-12-03 |