49th week of 2013 patent applcation highlights part 58 |
Patent application number | Title | Published |
20130324374 | WEIGHT TRAINING MACHINES - A weight training machine for allowing at least two of a user's muscle groups to push or pull simultaneously in a synchronized and unified fashion, having at least one common counter or weight resistance mechanism; a first actuating means operatively connected to the at least one common counter or weight resistance mechanism for allowing actuation of the at least one common counter or weight resistance mechanism by a first of the user's muscle groups, and a second actuating means operatively connected to the at least one common counter or weight resistance mechanism for allowing actuation of the at least one common counter or weight resistance mechanism by a second of the user's muscle groups, wherein actuation of both the first actuating means and the second actuation means simultaneously acts upon and or resists against the at least one common counter or weight resistance mechanism. One embodiment is an exercise machine and a drive or actuating mechanism with a lever and fulcrum configuration. The fulcrum has an attached handle, arm, lever or platform means, bearings for operatively cooperating with an axle and/or the lever, and attachment means for additional actuating member or members being operatively connected to the axle. The lever has a means for contact with the user and a weight means for providing a counterweight to the weight of the user, as well as attachment means for operatively connecting with the fulcrum and/or axle. The actuating member or members are attached to the fulcrum, preferably pivotally, and comprise linkages to the axle and/or lever so as to be able to transfer force from the user to the lever. Other embodiments include weight training machines having a moment arm weight, weight stack, or weight plate weight resistance mechanism for creating a weight resistance or weight load. | 2013-12-05 |
20130324375 | WEIGHT APPARATUS INCLUDING WEIGHT ADJUSTMENT ARRANGEMENT - A weight apparatus includes a bar including a handle, an anchorage rotatably mounted to an end of the handle, the handle and the anchorage having an axially extending opening, a pinion gear rotatably mounted in the axially extending opening, a rod slidably disposed inside the axially extending opening and having a rack arranged to be moved axially relative to the axially extending opening upon rotation of the pinion gear, and a gear drive arrangement for rotating the pinion gear upon rotation of the handle relative to the anchorage. | 2013-12-05 |
20130324376 | RESISTANCE TRAINING APPARATUS - A resistance training apparatus includes a resistance member, and a handle assembly arranged to reciprocate between proximal and distal positions against the resistance of the resistance member. The handle assembly includes a yoke. The yoke includes a first arm and an opposed second arm. The first arm has a first inner end and an opposed first outer end, and the second arm has a second inner end an opposed second outer end. A first handle is carried by the first end of the first arm, a second handle is carried by the second end of the second arm, and a third handle is connected between the first and second arms. The third handle extends between the first and second arms and is located between, on the one hand, the first and second handles and, on the other hand, the first and second inner ends of the first and second arms. | 2013-12-05 |
20130324377 | EXERCISE EQUIPMENT - The invention disclosed herein provides an apparatus, system and method for enhancing exercise effectiveness via resistance wraps. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 2013-12-05 |
20130324378 | Removably Mounted Exercise Station - A removably mounted exercise station includes an elongated anchoring member disposed on a first surface of an external stationary object, such as a door. The anchoring member has a plurality of apertures and rails formed between the apertures. A securing strap wraps around a second surface of the external stationary object to secure the exercise station onto the external stationary object. A resistance band connects to one of the rails to provide resistance during an exercise routine. A clamp allows for quick connect and disconnect of the resistance band to the rails. | 2013-12-05 |
20130324379 | APPARATUSES AND METHODS FOR EXERCISING THE ARM - In one embodiment, an exercise apparatus for exercising an arm includes a lever adapted to attach to a wheel of a wheelchair, a forearm support pivotally mounted to the lever that is adapted to support a forearm of a wheelchair user during exercise, and a resilient member attached to the lever that is adapted to resist movement of the lever by the user. | 2013-12-05 |
20130324380 | MEDICAL EXERCISE DEVICE - Disclosed is an intra-vaginal device of a new and innovative design that in combination with kegel exercises or performing ones daily routine strengthens the muscles of the pelvic floor. The device employs a combination of unique shape, materials as well as carefully engineered deflection, frictional, testing and clean-ability characteristics with particular attention to a sexually neutral appearance, comfort during insertion and exercise as well as positive physical feedback to encourage prolonged and frequent use. Benefits of the device include improvement or prevention of urinary leakage and prolapse, increases in sexual intensity, to keep the uterus/bladder/rectum in place as a pessary as well as relief for women suffering from moderate prolapse. As a dilator to aid women who suffer from vaginismus. With its multiple features and benefits, the device is a vital tool in a woman's quest for a complete and balanced wellness regimen. | 2013-12-05 |
20130324381 | Medical Exercise Device - Disclosed is an intra-vaginal device of a new and innovative design that in combination with kegel exercises or performing ones daily routine strengthens the muscles of the pelvic floor. The device employs a combination of unique shape, materials as well as carefully engineered deflection, frictional, testing and clean-ability characteristics with particular attention to a sexually neutral appearance, comfort during insertion and exercise as well as positive physical feedback to encourage prolonged and frequent use. Benefits of the device include improvement or prevention of urinary leakage and prolapse, increases in sexual intensity, to keep the uterus, bladder or rectum in place as a pessary as well as relief for women suffering from moderate prolapse. As a dilator to aid women who suffer from vaginismus. With its multiple features and benefits, the device is a vital tool in a woman's quest for a complete and balanced wellness regimen. | 2013-12-05 |
20130324382 | MULTI-FUNCTION EXERCISE MAT WITH DETACHABLE IMPLEMENTS AND METHOD - A non-planar exercise mat is disclosed comprising a plurality of detachable handheld implements, each handheld implement serving utilitarian function independently of the mat. Various embodiments of the present invention comprise permanently affixed or detachable cushions for tail-bone support; lumbar support; neck support, and the like. Various embodiments include handles for assisting a user in performing a variety of exercises upon, or optionally using, the mat. | 2013-12-05 |
20130324383 | Portable Calisthenics Exercise Device - A device for supporting an exerciser performing callisthenic exercises that includes a right and left, rigid, upright frame supports and an intermediate fork assembly. The fork assembly is adjustable in length and linked to the front sections of the two frame supports. Each frame support is angled inward to provide greater stability. The rear sections of the frame supports are detached and may be rotated laterally to reposition the gripping surfaces on the two frame supports and to adjust the size of the exercise area formed in between the two frame supports to accommodate different individuals and exercises. Each frame support includes a front leg and rear leg that allows height adjustment of each frame support. The device may include a pair of first handles, a pair of second handles attached to the two frame supports, and a suspension seat and one or two horizontal bars. | 2013-12-05 |
20130324384 | BEARING ARRANGEMENT AND ROLLING UNIT FOR A ROLLING-MILL ROLL - The invention relates to a bearing arrangement and a rolling unit for a rolling-mill roll. The bearing arrangement comprises a bearing housing, a bearing bush ( | 2013-12-05 |
20130324385 | DEVICE FOR SHAPING A FLAT BLANK INTO A CONTAINER - In a device for shaping a flat blank ( | 2013-12-05 |
20130324386 | BAG MAKING MACHINE - A bag making machine includes a feeder to unwind and feed a sheet in a first direction, a forming device to bend and fold the sheet to form a tubular body, a speed controller for controlling upstream and downstream speeds of advancement of the tubular body, a cutter to cut the tubular body into a plurality of tubular pieces, a direction changing device to change a direction of advancement of the tubular pieces so that the tubular pieces are advanced in a second direction substantially perpendicular to the first direction, a sewing device to sew and close an open bottom side of each of the tubular pieces, and a sealing device to hot press a sealing tape against the bottom side of each of the tubular pieces. | 2013-12-05 |
20130324387 | SHEET PROCESSING APPARATUS, IMAGE FORMING APPARATUS, AND IMAGE FORMING SYSTEM - A sheet processing apparatus which has a flattening processing unit which presses a folded end of a folded booklet bundle to flatten the folded end, and cutting units which cut and align edges of the booklet bundle, wherein the edges crossing the folded end of the booklet bundle are cut by the cutting unit and the folded end of the booklet is then flattened by the flattening processing unit. | 2013-12-05 |
20130324388 | METHOD AND DEVICE FOR SEPARATING AND TRANSFERRING CONTAINER CONTENTS BY DYNAMICAL USE OF CENTRIFUGE FORCE - The present invention relates to a method and device for separating and transferring container ( | 2013-12-05 |
20130324389 | GLASS COMPOSITION, GLASS SUBSTRATE FOR SOLAR CELLS USING GLASS COMPOSITION, AND GLASS SUBSTRATE FOR DISPLAY PANEL - The present invention relates to a glass composition including, in terms of mol % on the basis of oxides: from 55 to 70% of SiO | 2013-12-05 |
20130324390 | SCALABLE LEAD ZIRCONIUM TITANATE (PZT) THIN FILM MATERIAL AND DEPOSITION METHOD, AND FERROELECTRIC MEMORY DEVICE STRUCTURES COMPRISING SUCH THIN FILM MATERIAL - A novel lead zirconium titanate (PZT) material having unique properties and application for PZT thin film capacitors and ferroelectric capacitor structures, e.g., FeRAMs, employing such thin film material. The PZT material is scalable, being dimensionally scalable, pulse length scalable and/or E-field scalable in character, and is useful for ferroelectric capacitors over a wide range of thicknesses, e.g., from about 20 nanometers to about 150 nanometers, and a range of lateral dimensions extending to as low as 0.15 μm. Corresponding capacitor areas (i.e., lateral scaling) in a preferred embodiment are in the range of from about 10 | 2013-12-05 |
20130324391 | METHOD TO PREPARE FULL MONOLAYER OF PLATINUM ON PALLADIUM BASED CORE NANOPARTICLES - A method for forming catalytic nanoparticles includes forming core-shell catalytic nanoparticles and processing the core-shell catalytic nanoparticles. The core-shell catalytic nanoparticles have a palladium core enclosed by a platinum shell. The core-shell catalytic nanoparticles are processed to increase the percentage of the surface area of the core-shell catalytic nanoparticles covered by the platinum shell. | 2013-12-05 |
20130324392 | Porous Alumina Material, Process for Producing Same, and Catalyst - Provided is a production method for a porous alumina material, comprising the steps of: mixing an alkoxysilane solution that comprises an alkoxysilane, a mixed solvent comprising water and an alcohol, and an inorganic acid, with an aluminum solution comprising an aluminum compound and water, to prepare a mixed solution in which the aluminum compound and the alkoxysilane are dissolved in the mixed solvent; co-precipitating aluminum hydroxide with a silicon compound in the mixed solution, to form a precipitate; and baking the precipitate to form a porous alumina material comprising aluminum oxide and silicon oxide. | 2013-12-05 |
20130324393 | Novel Visible-Light-Responsive Photocatalyst with Environmental Resistance - To provide a novel visible light-responsive photocatalyst or tungsten oxide visible light-responsive semiconductor improved in environmental resistance under an alkaline condition. | 2013-12-05 |
20130324394 | METHOD OF FORMING A CATALYST WITH AN ATOMIC LAYER OF PLATINUM ATOMS - A method of forming a catalyst material includes hindering the reaction rate of a displacement reaction and controlling the formation of platinum clusters, where an atomic layer of metal atoms is displaced with platinum atoms, to produce a catalyst material that includes an atomic layer of the platinum atoms. | 2013-12-05 |
20130324395 | POROUS INORGANIC/ORGANIC HYBRID MONOLITH MATERIALS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESS FOR THEIR PREPARATION - Novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials. In particular, the novel materials are porous inorganic/organic hybrid monolith materials, which desirably may be surface modified, and which offer more efficient chromatographic separations than that known in the art. | 2013-12-05 |
20130324396 | METHOD FOR PRODUCING WATER-ABSORBENT RESIN - A method for producing a water-absorbent resin includes a polymerization step of polymerizing a polymerizable component containing a water-soluble ethylenically unsaturated monomer dissolved in water using a water-soluble azo-type radical polymerization initiator to obtain a reaction system including a water-absorbent resin precursor, and a dehydration step of removing water from the reaction system by heating. In the dehydration step, a water-soluble radical polymerization initiator is added to the reaction system at any first dehydration stage when the residual water rate calculated by the formula (1) is 50% or more, and a reducing substance is added to the reaction system at any second dehydration stage when the residual water rate decreases from that at the first dehydration stage by 10% or more. According to this production method, a water-absorbent resin having satisfactory water-absorption capacity can be produced while suppressing the content of residual monomers. | 2013-12-05 |
20130324397 | CARBON ADSORBENT FOR HYDROGEN SULFIDE REMOVAL FROM GASES CONTAINING SAME, AND REGENERATION OF ADSORBENT - A durable carbon pyrolyzate adsorbent having reversible sorptive affinity for hydrogen sulfide, and including the following characteristics: (a) a bulk density as measured by ASTM D2854 in a range of from 0.55 g/cc adsorbent to 1.25 g/cc adsorbent; (b) an H | 2013-12-05 |
20130324398 | ADSORBENT FOR ADSORBING VIRUS AND/OR BACTERIUM, CARBON/POLYMER COMPOSITE AND ADSORBENT SHEET - [Object] To provide an adsorbent, an adsorbent sheet, and a carbon/polymer composite for adsorbing a virus having further improved virus adsorption capability. | 2013-12-05 |
20130324399 | FUNGICIDAL COMPOSITIONS AND METHODS OF USE - Compositions and methods for protecting plants from fungal, bacterial, and viral diseases are provided, which compositions comprise at least one compound that produces systemic acquired resistance and at least one antifungal compound. Compositions of the disclosure may be applied directly to seeds, seedlings, shoots, roots, and/or foliage of the plant to be protected, thereby protecting them from the fungal, bacterial, and viral diseases. | 2013-12-05 |
20130324400 | FUNGICIDAL COMPOSITIONS AND METHODS - Provided are methods for reducing the occurrence of sudden death syndrome in plants, such as soybeans, using compounds of the general formula (I). | 2013-12-05 |
20130324401 | METHODS AND COMPOSITIONS FOR CONTROLLING WEED INFESTATION AND IMPROVING GRASS QUALITY - Methods for controlling unwanted vegetation, such as weeds, to turfgrass by applying an active compound combination including a triazolinone herbicide, for example, sulfonylamino-carbonyl-triazolinone, and at least one sulfonylurea herbicides, to turfgrass is described herein. The disclosure also provides for active compound combinations and methods of improving turfgrass quality. | 2013-12-05 |
20130324402 | NEW ANTIFUNGAL COMPOSITIONS - The present invention relates to new antifungal compositions and their use in the treatment of agricultural products. | 2013-12-05 |
20130324403 | NEW ANTIFUNGAL COMPOSITIONS - The present invention relates to new antifungal compositions and their use in the treatment of agricultural products. | 2013-12-05 |
20130324404 | 1, 8 -DIAZASPIRO [4.5] DECANE- 2, 4 -DIONE DERIVATIVES USEFUL AS PESTICIDES - Novel compounds of the formula (I) wherein the substituents are as defined in claim | 2013-12-05 |
20130324405 | NEW ANTIFUNGAL COMPOSITIONS - The present invention relates to new antifungal compositions and their use in the treatment of agricultural products. | 2013-12-05 |
20130324406 | BALANCED SYSTEM AND METHOD FOR PRODUCTION OF MICROBIAL OUTPUT - A system and method for the production of microbial consortiums and by-product material is provided. A physical containment system comprising phase spaces arranged in a discrete order to favor specific biological reactions is also provided. Phase profiles and phase data sets include the pre-determined physical and biological parameters for the phase space transitions. Movement of material from one phase to the next is hydraulically balanced enabling working fluid to continuously move in a fixed direction and rate of flow. Continuous monitoring of phase profiles and phase data sets provide feedback to the system enabling alteration of the conditions in the system to control reactions therein. | 2013-12-05 |
20130324407 | Microbial Fermentation Methods and Compositions - The present invention provides methods for the cultivation of the | 2013-12-05 |
20130324408 | AAD-12 EVENT 416, RELATED TRANSGENIC SOYBEAN LINES, AND EVENT-SPECIFIC IDENTIFICATION THEREOF - This invention includes a novel aad-12 transformation event for herbicide tolerance in soybean plants—referred to herein as pDAB4468-0416. This invention includes a heterologous polynucleotide inserted into a specific site within the genome of a soybean cell. In some embodiments, said event/polynucleotide can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. Additionally, the subject invention provides assays for detecting the presence of the subject event in a sample (a soybean, for example). The assays can be based on the DNA sequence of the recombinant construct, inserted into the soybean genome, and on the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the assays are also provided. | 2013-12-05 |
20130324409 | CONTROL OF PLANT STRESS TOLERANCE, WATER USE EFFICIENCY AND GENE EXPRESSION USING NOVEL ABA RECEPTOR PROTEINS AND SYNTHETIC AGONISTS - The present invention provides methods of regulating plant stress tolerance. | 2013-12-05 |
20130324410 | AGRICULTURAL ADJUVANT COMPOSITIONS, HERBICIDE COMPOSITIONS, AND METHOD FOR USING SUCH COMPOSITIONS - Pesticide compositions that contain, based on 100 pbw of such composition, (a) greater than or equal to about 0.006 parts by weight of a betaine surfactant, (b) greater than or equal to about 0.02 parts by weight of a humectant selected from polyhydric alcohols, polysaccharide humectants, and mixtures thereof, and (c) an effective amount of a pesticide, exhibit reduced foaming and high efficacy. | 2013-12-05 |
20130324411 | CHIMERIC PROMOTERS FOR USE IN PLANTS - The present invention provides polynucleotide molecules useful for expressing transgenes in plants. The present invention also provides expression constructs containing the polynucleotide molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the polynucleotide molecules useful for expressing transgenes in plants. | 2013-12-05 |
20130324412 | N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS - N-Alkoxyamides of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are selective herbicides for corn, canola and sugar beet. | 2013-12-05 |
20130324413 | METHOD FOR PROMOTING PLANT GROWTH - The present invention provides a method for promoting the growth of a plant which comprises treating the plant with an effective amount of a compound represented by formula (1); and so on. | 2013-12-05 |
20130324414 | SOLID-STATE CATALYSIS OF SUPERCONDUCTING CUPRATES - Catalytically active (001) ceria substrates or buffers are used to modify the structure of the epitaxial high temperature superconductor YBa | 2013-12-05 |
20130324415 | OXIDE SUPERCONDUCTING THIN FILM - The invention provides an oxide superconducting thin film, including: a base material; a superconducting layer containing a plurality of RE-based superconductor units including a rare earth element, CuO chains, and CuO | 2013-12-05 |
20130324416 | Methods and Compositions for Correlating Genetic Markers with Cardiovascular Disease - The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31. | 2013-12-05 |
20130324417 | DETERMINING THE CLINICAL SIGNIFICANCE OF VARIANT SEQUENCES - The present invention generally relates to determining the clinical significance of a variant nucleic acid sequence. The invention can involve sequencing a nucleic acid to generate at least one sequence read, identifying a variant sequence within the sequence read, determining the equivalent insertion/deletion region (EIR) of the variant sequence, identifying a functional region including at least a portion of the EIR, and associating the EIR with the identified functional region, thereby to determine the clinical significance of the variant. | 2013-12-05 |
20130324418 | Analysis Of Rare Cell-Enriched Samples - The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from the subject. | 2013-12-05 |
20130324419 | METHODS FOR NUCLEIC ACID CAPTURE AND SEQUENCING - Methods of capturing and sequencing target nucleic acid molecules are provided. Methods of determining the methylation status of genomic DNA are also provided. | 2013-12-05 |
20130324420 | NORMALIZING CHROMOSOMES FOR THE DETERMINATION AND VERIFICATION OF COMMON AND RARE CHROMOSOMAL ANEUPLOIDIES - The present invention provides a method capable of detecting single or multiple fetal chromosomal aneuploidies in a maternal sample comprising fetal and maternal nucleic acids, and verifying that the correct determination has been made. The method is applicable to determining copy number variations (CNV) of any sequence of interest in samples comprising mixtures of genomic nucleic acids derived from two different genomes, and which are known or are suspected to differ in the amount of one or more sequence of interest. The method is applicable at least to the practice of noninvasive prenatal diagnostics, and to the diagnosis and monitoring of conditions associated with a difference in sequence representation in healthy versus diseased individuals. | 2013-12-05 |
20130324421 | METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in the concentration of inorganic pyrophosphate (PPi), hydrogen ions, and nucleotide triphosphates. | 2013-12-05 |
20130324422 | DETECTING DISEASE-CORRELATED CLONOTYPES FROM FIXED SAMPLES - The invention is directed to a method for determining immunophenotypes of tissue-infiltrating lymphocytes in a solid tissue of a patient by (a) generating clonotype profiles from a sample of nucleic acid extracted from a fixed tissue sample from a solid tissue of the patient, where such tissue contains tissue-infiltrating lymphocytes; and (b) determining immunophenotypes of the tissue-infiltrating lymphocytes by (i) obtaining a sample of lymphocytes from peripheral blood of the patient; (ii) sorting the lymphocytes from peripheral blood into at least one subset based on different immunophenotypes of the lymphocytes; (iii) generating a clonotype profile for each of the at least one subset of lymphocytes; and (iv) determining immunophenotypes of lymphocytes in the fixed tissue sample by a correspondence between clonotypes of the fixed tissue sample and clonotypes of the at least one subset. | 2013-12-05 |
20130324423 | NEW ANIMAL MODEL FOR DIABETIC COMPLICATIONS - The invention relates to the surprising find that low density lipoprotein receptor-deficient mice (LDLr−/−) mice when fed with high energy diets produce controllable and consistent diabetic complications, especially renal damage, similar to the human pathophysiology and biological response. The invention thus comprises a method for discovering a preventive or therapeutic regimen for the prevention or treatment of diabetic micro- or macrovascular complications, comprising the steps of: a. feeding LDLr−/− mice, which have not been treated with streptozotocin, with a high energy diet; b. before, during and/or after this diet treating the mice with the preventive or therapeutic regimen; c. checking whether any change in the micro- or macrovascular system of the animal occurs. Specifically in such a method renal damage is assessed. Also use of said mice fed with a high energy diet for studying the diabetic micro- and macrovascular complications is part of the invention. | 2013-12-05 |
20130324424 | SCANNING DROP SENSOR - Electrochemical experiments are performed on a collection of samples by suspending a drop of electrolyte solution between an electrochemical experiment probe and one of the samples that serves as a test sample. During the electrochemical experiment, the electrolyte solution is added to the drop and an output solution is removed from the drop. The probe and collection of samples can be moved relative to one another so the probe can be scanned across the samples. | 2013-12-05 |
20130324425 | IDENTIFICATION OF THERAPEUTIC TARGETS FOR COMPUTER-BASED DESIGN OF DRUGS AGAINST BACTERIA CONTAINING THE PILT PROTEIN - The present invention relates to a method for identifying target regions existing in the interface of monomers constituting the PiIT protein with the view to design molecules potentially applicable in impairing the activity of this protein, thus controlling infectious processes. The method is characterized in (i) selecting at least one amino acid sequence constituting the PiIT monomer; (ii) developing a three-dimensional computational model of the PiIT homo-hexameric structure; (iii) analyzing and determining, with computer aid, the interface-forming residues (IFR) and their physicochemical and structural characteristics for all the chains of the models of hexameric complexes generated; (iv) selecting the regions to be used as therapeutic targets (and preferred therapeutic targets) in the interface between the monomers based on the intensity of determined parameters; (v) computer-aided design of molecules potentially capable of effecting bindings and/or interactions between target regions of the monomers. Markedly, some of the main applications of this technology consist in combating the bacteria | 2013-12-05 |
20130324426 | Method to improve protein production - Method to create in silico protein mutants with improved expression level in an expression host compared to an original protein. The mutants retain unaltered or minimally altered function and specific activity that is at the same or higher level compared to the original protein. The method also allows predicting one or more optimal expression host(s) for the given protein and mutants for maximum production level in the predicted optimal host(s). The method is based on optimizing protein sequence parameters that are important for protein expression, such as amino acid composition, guanine-cytosine (GC) content, RNA secondary structure, amount of charged amino acids on the surface, and length of the protein, among other parameters. | 2013-12-05 |
20130324427 | ASSESSMENT AND REDUCTION OF RISK OF GRAFT-VERSUS-HOST DISEASE - Methods of assessing and reducing risk of graft versus host disease (GVHD) based on gene expression profiling are described, as well as methods of selecting a suitable transplant donor. Corresponding reagents and kits are also described. | 2013-12-05 |
20130324428 | SPECIFIC BIOMARKER FOR IDENTIFICATION OF EXPOSURE TO LOWER ALIPHATIC SATURATED ALDEHYDES AND THE METHOD OF IDENTIFICATION USING THE SAME - The present invention relates to a biomarker for the identification of specific exposure to lower aliphatic saturated aldehydes which are volatile organic compounds exposed in the environment, and a method for the identification of specific exposure to lower aliphatic saturated aldehydes using the same, precisely a biomarker which is up- or down-regulated specifically by lower aliphatic saturated aldehyde exposure and a method for the identification of specific exposure to lower aliphatic saturated aldehydes using the biomarker. The biomarker of the present invention is the reacted genes selected by using DNA microarray chip, which can be effectively used for the monitoring and evaluation of lower aliphatic saturated aldehyde contamination in the environment samples and at the same time as a tool for the investigation of the toxic mechanism induced specifically by lower aliphatic saturated aldehydes. | 2013-12-05 |
20130324429 | MicroRNAs For Identification Of Exposure To Lower Aliphatic Saturated Aldehydes And The Method Of Identification Using Thereof - The present invention relates to a biomarker for the identification of exposure to lower aliphatic saturated aldehydes by using micro RNA and a method for the identification of exposure to lower aliphatic saturated aldehydes using the same. In this invention, the micro RNA at least 1.5 fold up-regulated by exposure to lower aliphatic saturated aldehydes and the micro RNA up to 0.66 fold down-regulated by the same were selected. These two micro RNAs can be effectively used as the biomarker for the monitoring of lower aliphatic saturated aldehydes and for the risk assessment thereby and at the same time as a tool to investigate the mechanism of toxicity caused by such lower aliphatic saturated aldehydes. | 2013-12-05 |
20130324430 | DRUG SELECTION FOR COLORECTAL CANCER THERAPY USING RECEPTOR TYROSINE KINASE PROFILING - The present invention provides methods for selecting a suitable anticancer drug therapy, and for identifying and predicting response, for the treatment of colorectal cancer. The present invention also provides methods for monitoring the status of colorectal cancer and monitoring how a patient with colorectal cancer is responding to anticancer drug therapy. The present invention further provides methods for the rational selection of therapy with one or more anticancer drugs tailored to target signal transduction pathway components with dysregulated expression and/or activation levels in patients with somatic mutations in an oncogene. | 2013-12-05 |
20130324431 | OLFACTORY RECEPTOR COPY NUMBER ASSOCIATION WITH AGE AT ONSET OF ALZHEIMER'S DISEASE - The present invention concerns determination of risk for an early age of onset for Alzheimer's Disease in an individual. In specific embodiments, it concerns identification of copy number at chromosome 14q11.2 or a region thereof and associating a high copy number with an earlier age of onset of Alzheimer's Disease. | 2013-12-05 |
20130324432 | BIN1 EXPRESSION AS A MARKER OF SKELETAL MUSCLE MASS AND NEUROLOGICAL CONDITIONS - Provided are methods for determining skeletal muscle mass in subject. Also provided are methods for diagnosing a neurological condition or disease or a condition or disease associated with reduced skeletal muscle mass in a subject. Further provided are purified antibodies that bind specifically to a BIN1 polypeptide that is expressed specifically in skeletal muscle. | 2013-12-05 |
20130324433 | Agents and Methods Related to Reducing Resistance to Apoptosis-Inducing Death Receptor Agonists - Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins. | 2013-12-05 |
20130324434 | METHOD FOR THE DETECTION OF GENE TRANSCRIPTS IN BLOOD AND USES THEREOF - The present invention relates generally to the identification of biomarkers of conditions including disease and non-disease conditions as well as identifying compositions of biomarkers. The invention further provides a method of diagnosing disease, monitoring disease progression, and differentially diagnosing disease. The invention further provides for kits useful in diagnosing, monitoring disease progression and differentially diagnosing disease. | 2013-12-05 |
20130324435 | ESOPHAGEAL CYTOKINE EXPRESSION PROFILES IN EOSINOPHILIC ESOPHAGITIS - Methods and compositions disclosed herein generally relate to methods of providing or enhancing a diagnosis of eosinophilic esophagitis (EE). In particular, the invention relates to obtaining a sample from a patient having at least one indication of EE, then quantifying from the sample an amount of one or more cytokines associated with EE or an mRNA corresponding to the cytokine or its receptor, wherein an altered level of the cytokine or mRNA correlates with a positive diagnosis of EE. An EE diagnosis can then be provided or enhanced, based upon the quantifying step. The invention further relates to diagnostic kits, tests, and/or arrays that can be used to quantify the one or more cytokines associated with EE or an mRNA corresponding to the cytokine or its receptor. | 2013-12-05 |
20130324436 | PROCEDURE FOR NUCLEIC ACID-BASED DIAGNOSTIC DETERMINATION OF BACTERIAL GERM COUNTS AND KIT FOR THIS PURPOSE - Disclosed are procedures and kits for nucleic acid-based molecular diagnostic determination of bacterial germ counts during which procedure evolutionarily conserved genes and genes coding for characteristic pathogenicity markers, favourably microbial enzyme, toxin, special resistance, are detected using real-time PCR amplification method with the application of fluorescent hydrolysis probes. The multiplication of nucleotide chains takes place with oligonucleotides annealing to the structural gene 5′ end region and to the adjacent upstream regulatory promoter-operator region so that the presence of the structural gene is shown along with the adjacent upstream regulatory promoter-operator sequences; the functional nature of the structural gene is simultaneously checked. The result is measured with a genome unit equivalent DNA amount calibrated to the germ number of sample units equivalent to standard procedures. The calibrated determination of bacterial germ counts is favourably based on single copy gene sequences in the genome, like those coding for characteristic pathogenicity markers. | 2013-12-05 |
20130324437 | METHOD FOR IDENTIFYING ANTIMICROBIAL COMPOUNDS AND DETERMINING ANTIBIOTIC SENSITIVITY - Provided herein are improved methods of characterizing antibiotic agents according to the effect the antibiotic agent has on a bacterial cell. This allows for rapid screening of potential antibiotic agents, e.g., for improved antibiotics, and classification of antibiotic agents. The present techniques also allow for profiling of bacterial strains for susceptibility of antibiotic agents and, e.g., determining which are most susceptible to particular modes of action. | 2013-12-05 |
20130324438 | METAGENE EXPRESSION SIGNATURE FOR PROGNOSIS OF BREAST CANCER PATIENTS - Described are gene expression signatures able to distinguish individuals having or suspected to have breast cancer with good clinical prognosis from individuals with poor clinical prognosis, based on ZEB2 transcriptional activity. Further described are kits and assays related to the prognosis and/or the change in prognosis of the individuals suffering from breast cancer. | 2013-12-05 |
20130324439 | Elastic Modulus-modified MicroEnvironment microArrays (eMEArrays) and Uses Thereof - A combinatorial elastic modulus-modified microenvironment microarray (eMEArray) platform and methods for cell-based functional screening of interactions with combinatorial microenvironments. The platform and methods allow for simultaneous control of the molecular composition and the elastic modulus, and combines the use of microarray and micropatterning technologies. The eMEArrays have been used to show that the microenvironment has effects on drug-cell interactions and contributes to therapeutic response. | 2013-12-05 |
20130324440 | METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS - The present application relates to a system for designing promoters for selective expression of genes. Thereby identified transcription regulatory elements are selected according to a specific methodology and used to create a library of transcription regulatory elements, which are then used to construct specific promoters, especially tissue-specific promoters. | 2013-12-05 |
20130324441 | Drilling Fluids Useful For Limiting Tar Sand Accretion - A drilling fluid is provided that comprises a non-ionic or cationic polymer having general formula I or II. The drilling fluid may be used in drilling or other oilfield operations to prevent or limit the accretion of hydrocarbons to metal components when these are in contact with highly viscous hydrocarbons such as those present in formations containing heavy crude oil or tar sand. | 2013-12-05 |
20130324442 | Compositions and Method for Treating Out Hydrogen Sulfide and Preventing Settling of Precipitate in an Environmentally Responsible Drilling and Packer Fluid - An environmentally responsible iron chelating additive and method for removing hydrogen sulfide or sulfide ions from drilling and packer fluids and preventing settling of precipitates. Iron chelating agents selected from the group consisting of ferrous lactate, ferrous gluconate, ferrous bis glycinate, ferrous citrate, ferrous acetate, ferrous fumarate, ferrous succinate, ferrous sacchrate, ferrous tartarate, ferrous glycine sulfate, ferrous glutamate, ferrous ascorbate, ferrous polymaltose, or a combination thereof, may be used. When the fluids are oil based, the iron chelating agents are added to the water phase of an emulsion, and the emulsion is added to the fluid. Viscosifiers may also be added to the drilling fluid with the emulsion. | 2013-12-05 |
20130324443 | SALT-TOLERANT, THERMALLY-STABLE RHEOLOGY MODIFIERS - A salt-tolerant, thermally-stable rheology modifier and, in particular, a rheology modifier for applications in oil-field well-bore fluids. In accordance with one aspect, the rheology modifier comprises a terpolymer of acrylamide, 2-acrylamido-2-methyl-propanesulfonic acid (AMPS) and a long-chain alkyl acrylate wherein the terpolymer is prepared by dispersion polymerization. | 2013-12-05 |
20130324444 | SYSTEM AND METHOD FOR DELIVERING TREATMENT FLUID - The current application discloses methods and systems for preparing a wellbore treatment fluid precursor consolidated as one or more solid bodies; delivering the solid bodies to a logistics facility; and preparing a wellbore treatment fluid from the solid bodies. In some embodiments, the wellbore treatment fluid is a fracturing fluid for conducting a hydraulic fracturing operation on a subterranean formation penetrated by a wellbore. | 2013-12-05 |
20130324445 | Microemulsion and Nanoemulsion Breaker Fluids With Organic Peroxides - Incorporating at least oil-soluble organic peroxide into a mixture of an aqueous phase and at least one surfactant creates a breaker fluid that is a microemulsion or a nanoemulsion that can then perform as an internal breaker for reducing the viscosity of aqueous fluids gelled with a polymer, such as a crosslinked polysaccharide. One phase of the breaker fluid is water or water-based, e.g. brine, containing at least one oil-soluble organic peroxide as a non-aqueous internal phase that will, over time and optionally with heat, break the polymer-gelled portion of the gel. The overall breaking using the breaker fluid is slower as compared to introducing the organic peroxide breaker in a non-microemulsified or non-nanoemulsified form. | 2013-12-05 |
20130324446 | EMULSION BREAKERS INCLUDING POLYESTER FUNCTIONALITIES - An emulsion breaker composition, a method of making the emulsion breaker, and method of breaking an emulsion are disclosed. In one method, an emulsion is contacted with an effective amount of an emulsion breaker composition. The emulsion breaker is a linear or branched polymer having at least one branch, wherein each branch has a first polymer block having a backbone including a plurality of ester groups and a second polymer block including an alkoxylate, and wherein at least two of the ester groups are connected by a —CR1R2 group. The emulsion breakers are preferably formed by reacting a polyol with a cyclic ester monomer in the presence of a first catalyst to form an intermediate polymer having a plurality of branches, wherein each branch has a backbone including a plurality of ester groups, and then reacting the intermediate polymer with at least one alkylene oxide species in the presence of a second catalyst to form an alkoxylate block on each branch. | 2013-12-05 |
20130324447 | LUBRICANT COMPOSITIONS AND PROCESSES FOR PREPARING SAME - Provided is a method for stabilizing a dispersion of a carbon nanomaterial in a lubricating oil basestock. The method includes providing a lubricating oil basestock; dispersing a carbon nanomaterial in the lubricating oil basestock; and adding at least one block copolymer thereto. The at least one block copolymer has two or more blocks includes at least one alkenylbenzene block and at least one linear alpha olefin block. The at least one block copolymer is present in an amount sufficient to stabilize the dispersion of the carbon nanomaterial in the lubricating oil basestock. Also provided is a lubricating engine oil having a composition including: a lubricating oil base stock; a carbon nanomaterial dispersed in the lubricating oil basestock; and at least one block copolymer. | 2013-12-05 |
20130324448 | Antiwear Composition and Method of Lubricating Driveline Device - The present invention relates to an antiwear agent and lubricating compositions thereof. The invention further provides for a method of lubricating a driveline device application by employing a lubricating composition containing the antiwear agent. | 2013-12-05 |
20130324449 | PROCESS FOR PRODUCING KETONES FROM FATTYACIDS - The invention relates to a process for producing ketones or hydrocarbon base oil from fatty acids preferably derived from a biological origin or other renewable source. The process is directed at making an aliphatic ketone or a mixture of aliphatic ketones having 14 to 52 carbon atoms, comprising a ketonization reaction of a fatty acid in a vapor phase with a decarboxylation-coupling catalyst to provide ketones, which can be deoxygenated to give saturated hydrocarbons, unsaturated hydrocarbons, and mixtures thereof. Base oils and transportation fuels may be produced from the process herein. | 2013-12-05 |
20130324450 | CONSUMER PRODUCTS CONTAINING PRO-FRAGRANCES - The invention relates to novel liquid compositions, comprising: a) a liquid base intended for the treatment of surfaces, in particular fabrics or hard surfaces; b) at least one sulfur-containing compound of formula wherein R | 2013-12-05 |
20130324451 | Quaternized Polyethulenimines with a High Ethoxylation Degree - The present invention relates to an ethoxylated polyethylenimine polymer comprising (1) a polyethyleneimine backbone, (2) a polyoxyethylene chain wherein the polyoxyethylene chain has an average of 40 to 90 ethyleneoxide units per unit of NH in the polyethyleneimine backbone, (3) a quaternization degree of from 1% to less than 50%. | 2013-12-05 |
20130324452 | SPRAY-DRIED DETERGENT POWDER - The present invention is a spray-dried powder comprising: (i) from 20 to 80 wt % of a first spray-dried particle comprising less than 5 wt % sulphate, anionic detersive surfactant and having a bulk density of from 300 g/l to 450 g/l: and (ii) from 20 to 80 wt % of a second spray-dried particle comprising at least 45 wt % sulphate, 0 wt % to 15 wt % anionic detersive surfactant, and having a bulk density of from 350 g/l to 700 g/l. | 2013-12-05 |
20130324453 | METHOD FOR MAKING A PARTICLE COMPRISING SULPHATE - A process for making a particle comprising at least 45 wt % sulphate, from 0 wt % to 15 wt % anionic detersive surfactant, and having a bulk density of from 350 g/l to 700 g/l, comprising the steps of; (a) preparing an aqueous slurry comprising sulphate, and optionally detersive surfactant; (b) drying the particle; and wherein the sulphate added to the aqueous slurry has a volume average particle size of from 10 micrometers to 50 micrometers. | 2013-12-05 |
20130324454 | LAUNDRY DETERGENT COMPOSITIONS - The present invention is to a laundry detergent powder comprising: (i) from 20 to 80 wt % of a first particle comprising less than 55 wt % sulphate, anionic detersive surfactant, and having a bulk density of from 300 g/l to 1100 g/l: and (ii) from 20 to 80 wt % of a second particle comprising at least 55 wt % sulphate and, having a bulk density of from 350 g/l to 600 g/l, and a process to making the laundry detergent powder. | 2013-12-05 |
20130324455 | SOLIDIFICATION MECHANISM INCORPORATING IONIC LIQUIDS - A solid cleaning composition including an ionic liquid and a hardening agent is provided. The compositions are substantially free of alkyl phenol ethoxylates, including nonyl phenol ethoxylates. The solid cleaning compositions remain solid at room temperature despite the inclusion of ionic liquids, providing an effective, biorenewable, environmentally friendly alternative to nonyl phenol ethoxylate cleaning compositions. | 2013-12-05 |
20130324456 | SPRAY-DRIED DETERGTENT POWDER - The present invention is a spray-dried powder comprising: at least 5 wt % of a spray-dried particle comprising at least 40 wt % anionic detersive surfactant, from 15 to 40 wt % carbonate and less than 20 wt % sulphate and having a bulk density of from 300 g/l to 450 g/l. | 2013-12-05 |
20130324457 | 1-ARYL-5-ALKYL PYRAZOLE DERIVATIVE COMPOUNDS, PROCESSES OF MAKING AND METHODS OF USING THEREOF - Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): | 2013-12-05 |
20130324458 | METHODS AND COMPOSITIONS USING KLOTO-FGF FUSION POLYPEPTIDES - The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion polypeptides of the invention include at least a Klotho protein or an active fragment thereof. In one embodiment, the fusion polypeptide comprises a Klotho polypeptide, a FGF (such as FGF23) and (optionally) a modified Fc fragment. The Fc fragment can, for example, have decreased binding to Fc-gamma-receptor and increased serum half-life. The Klotho fusion proteins are useful in the treatment and prevention of a variety of age-related conditions and metabolic disorders. In another embodiment, the fusion polypeptide comprises a FGF (such as FGF23) and a modified Fc fragment. | 2013-12-05 |
20130324459 | Compounds For Enzyme Inhibition - Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. | 2013-12-05 |
20130324460 | FIBROBLAST GROWTH FACTOR 21 VARIANTS - This present invention relates to pharmacologically potent and/or stable variants of human fibroblast growth factor 21 (FGF21), pharmaceutical compositions comprising FGF21 variants, and methods for treating type 2 diabetes, obesity, dyslipidemia, or metabolic syndrome, or any combination thereof, using such variants. | 2013-12-05 |
20130324461 | METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OBESITY - The invention includes methods of treating, preventing, or limiting obesity or weight gain, or reducing or suppressing appetite, by the administration of A2A adenosine receptor pathway agonists. The A2AR pathway agonists may be administered in conjunction with a therapeutic agent having a side effect of weight gain, in order to prevent or limit that weight gain. In some instances, the A2AR pathway agonist is administered as a sleeping pill, and in other instances the A2AR pathway agonist is administered in a non-drowsy formulation. | 2013-12-05 |
20130324462 | Method of Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides - The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described. | 2013-12-05 |
20130324463 | USE OF A DPP-4 INHIBITOR FOR MODIFYING FOOD INTAKE AND REGULATING FOOD PREFERENCE - The present invention relates to the use of a certain DPP-4 inhibitor for modifying food intake and regulating food preference. | 2013-12-05 |
20130324464 | ARYL GLYCOSIDE COMPOUND, PREPARATION METHOD AND USE THEREOF - Disclosed are an aryl glycoside compound as represented by formula I or formular I′, a pharmaceutically acceptable salt thereof, optical isomer thereof or a prodrug thereof. The present invention relates to a method of preparing said aryl glycoside compound and the use thereof The aryl glycoside compound of the present invention has an excellent ability on inhibit SGLT activity, especially SGLT2 activity, and is diabetes-fighting medicine with great potential. | 2013-12-05 |
20130324465 | VEGF ANTAGONIST COMPOSITIONS AND USES THEREOF - The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof. | 2013-12-05 |
20130324466 | Therapeutic Dosing of a Neuregulin or a Subsequence Thereof for Treatment or Prophylaxis of Heart Failure - The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects. | 2013-12-05 |
20130324467 | NEUROPEPTIDE ANALOGS, COMPOSITIONS, AND METHODS FOR TREATING PAIN - Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one or more neuropeptide analogs. | 2013-12-05 |
20130324468 | METHODS OF TREATING DISEASES ASSOCIATED WITH PPARy - The invention relates to methods for modulating PPAR-γ activity using relaxin or agonists thereof. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including small vessel disorders of the brain and those associated with increased blood-brain barrier permeability, cognitive disorders such as Alzheimer's disease, vascular dementia, epilepsy, stroke, CADASIL and migraine. | 2013-12-05 |
20130324470 | CROSS-LINKED GELATIN COMPOSITION COMPRISING A WETTING AGENT - Disclosed is a biocompatible, hemostatic, cross-linked gelatin composition comprising a biocompatible material comprising cross-linked gelatin and a sufficient amount of wetting agent to permit uniform wetting of the sponge in the presence of an aqueous solution. | 2013-12-05 |
20130324471 | TREATMENT - The present invention derives from the finding that increased levels of Toll like receptor 4 (TLR4) is associated with liver failure and renal dysfunction and/or brain dysfunction and that by decreasing TLR4 levels in vivo, the kidney and brain consequences of liver disease that are precipitated by superimposed infection or inflammation may be reduced. Accordingly, the invention provides TLR4 antagonists for use in a method of treating an individual suffering from liver disease presenting with renal or brain dysfunction. | 2013-12-05 |
20130324472 | THERAPEUTIC METHOD FOR TREATING CONGESTIVE HEART FAILURE - The present invention relates to a method of treating congestive heart failure (CHF) in a subject comprising administering a peptide derived from atrial natriuretic peptide (ANP) prohormone (eg vessel dilator; VSDL) or a mimetic thereof. In a particular application, the invention provides a method of treating the particular indication known as acute decompensated congestive heart failure (ADCHF). Devices for intravenous or subcutaneous infusion for use in the method of the invention are also disclosed. | 2013-12-05 |
20130324473 | Coagulating Collagen and Means for Preparing Same - The invention relates to the preparation and provision of a gelling collagen composition that instantaneously forms a collagen matrix, and means for the preparation and use thereof, in particular as part of a therapeutic treatment. | 2013-12-05 |
20130324474 | VARIANTS OF HUMAN GDNF - The present invention relates to novel variants of human glial cell-derived neurotrophic factor (GDNF) and methods for their use. | 2013-12-05 |