49th week of 2011 patent applcation highlights part 37 |
Patent application number | Title | Published |
20110300179 | Novel Compositions and Uses Thereof - The present invention provides a cellular vaccine for therapeutic or prophylactic treatment of a pathological condition, the vaccine comprising or consisting of a population of CD 4+ T cells modified such that they contain an antigenic component, and/or a nucleic acid molecule encoding an antigenic component thereof, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. The invention further provides an adjuvant composition for use in a method of vaccination, the composition comprising or consisting of a population of T cells, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. In addition, the invention provides a composition having microbicide activity, or capable thereof upon exposure to antigen-presenting cells, the composition comprising or consisting of a population of T cells, wherein the T cells are (a) activated, or capable of being activated, and (b) apoptotic, or capable or being made apoptotic. Also provided by the present invention are methods for making and using the vaccines and compositions described herein. | 2011-12-08 |
20110300180 | PLANT-DERIVED VACCINES AGAINST RESPIRATORY SYNCYTIAL VIRUS - A plant-derived vaccine against respiratory syncytial virus (RSV) is disclosed. The vaccine includes an immunogenic complex that includes plant cells transformed with a chimeric gene containing a nucleotide sequence adapted for protein expression in plants and an RSV coding sequence that encodes an antigenic protein of RSV. Also disclosed are methods of making the plant-derived vaccine of the invention, as well as transgenic plants, transgenic plant cells, and nucleic acid constructs useful in immunizing a mammal against RSV. | 2011-12-08 |
20110300181 | PURIFICATION OF VACCINIA VIRUS- AND RECOMBINANT VACCINIA VIRUS-BASED VACCINES - The present invention relates to methods for purification of Vaccinia viruses (W) and/or Vaccinia virus (W) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production. | 2011-12-08 |
20110300182 | NUCLEIC ACID DRUG FOR TREATMENT OF ALLERGIC DISEASE - This invention provides double-stranded (ds) RNA capable of suppressing the expression of STAT6 related to allergic diseases mediated by Th2-type cytokines via RNA interference and a pharmaceutical composition for prevention or treatment of allergic diseases comprising such dsRNA. Such dsRNA is a double-stranded RNA (dsRNA) molecule targeting mRNA of the STAT6 gene composed of (a) or (b): (a) a sense strand identical to a sequence having 15 to 50 continuous nucleotides in the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand; or (b) a sense strand comprising a sequence derived from the sequence comprising 15 to 50 continuous nucleotides of the STAT6 gene sequence represented by SEQ ID NO: 1 or 3 by deletion, substitution, or addition of 1 or several nucleotides and capable of hybridizing to the STAT6 gene and an antisense strand comprising a nucleotide sequence complementary to the nucleotide sequence of the sense strand. | 2011-12-08 |
20110300183 | METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPY - In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an antisense nucleic acid that downregulates expression of an adenosine receptor, for example. The immune cells may be tumor-infiltrating lymphocytes (TIL), cytotoxic T lymphocytes (CTL), natural killer (NK) cells, or lymphokine-activated killer (LAK) cells, for example. The methods described herein may be used to treat a number of diseases including cancer, infectious diseases, and immunodeficiencies. | 2011-12-08 |
20110300184 | PHARMACEUTICAL COMPOSITIONS FOR TREATING OR PREVENTING BONE CONDITIONS - Provided herein is a pharmaceutical composition for treating, preventing or ameliorating a bone or cartilage condition and methods of making and using the same. | 2011-12-08 |
20110300185 | IMMUNOGENIC ESCHERICHIA COLI HEAT STABLE ENTEROTOXIN - The present invention relates to methods and compositions for the treatment and prevention of diarrhea and diarrheal related diseases and disorders in both animals and humans. In some embodiments, the invention relates to the treatment of said diarrhea and diarrheal related diseases and disorders with a vaccine. In still further embodiments, the invention relates to the treatment of constipation using the disclosed methods and compositions. | 2011-12-08 |
20110300186 | Functionalized Nano- and Micro-materials for Medical Therapies - Compositions containing an optionally surface-functionalized mesoporous support and a biologically active agent, and pharmaceutical compositions of the same, are provided herein. Such compositions can be useful in the treatment of tumors, for example, by injection of the composition at a location near the site of the tumor. | 2011-12-08 |
20110300187 | ANTIOXIDANT CAMPTOTHECIN DERIVATIVES AND ANTIOXIDANT ANTINEOPLASTIC NANOSPHERES THEREOF - The present invention is directed to antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs and the preparation of nanometer-sized camptothecin prodrugs. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant camptothecin nanosphere prodrugs and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these antioxidant camptothecin nanosphere prodrugs for the preparation of delivery devices of other pharmaceuticals and/or drugs. Additionally, methods of treating cancer with the camptothecin and antioxidant derivatives of camptothecin analogs, and nanometer-sized camptothecin prodrugs are also provided. | 2011-12-08 |
20110300188 | Glassy calcium phosphate particulates, coatings and related bone graft materials - Calcium phosphate and related coating powder particles comprising a surface component comprising a silicate content, plasma sprayed coatings thereof on implantable medical/dental devices, and bone grafting materials of such coated particles. Optionally, biologically active agents such as bone morphogenetic proteins, growth factors, analgesics, and antibiotics can be incorporated therein. | 2011-12-08 |
20110300189 | ANTIMICROBIAL COLLOIDAL SILVER PRODUCTS AND METHOD OF MAKING SAME - Gelatinous materials combined with the Colloidal Silver additive to formulate an antimicrobial product having cushioning properties. Embodiments of the present invention can include gelatinous materials selected from a group consisting of thermosetting polymer, Styrene-Ethylene-Butadiene-Styrene polymer (SEBS), Thermoplastic Elastomer (TPE), and Polyurethane (PU) gelatin with and without a raised geometry on an outer surface. | 2011-12-08 |
20110300190 | COMPOUND, COMPOSITION AND USES THEREOF - The disclosure herein provides a compound of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof. The steps of synthesis of compound of formula I is described. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, or injection. Such compositions may be used to treatment of metabolic condition or neurodegenerative disorders or its associated complications. | 2011-12-08 |
20110300191 | MULTIPLE-LAYER IMMUNE BARRIER FOR DONOR CELLS - A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described. | 2011-12-08 |
20110300192 | MAGNESIUM OXIDE GRANULES - Magnesium oxide granules which are excellent in dissolution property, are palatable, rarely leave any rough feeling in the oral cavity and have a good color in appearance. | 2011-12-08 |
20110300193 | AMBIENT STORED BLOOD PLASMA EXPANDERS - A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described. | 2011-12-08 |
20110300194 | Flexible Bone Composite - The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric layer including a synthetic polymer. The calcium-containing layer can include a calcium compound such as β-Ca | 2011-12-08 |
20110300195 | Ophthalmic Compositions Comprising Calcineurin Inhibitors or mTOR Inhibitors - The embodiments disclosed herein relate to ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors, and more particularly to methods for treating an ocular disease and/or condition using the disclosed compositions. According to aspects illustrated herein, there is provided a pharmaceutical composition that includes a calcineurin inhibitor or an mTOR inhibitor; a first surfactant with an HLB index greater than about 10; and a second surfactant with an HLB index of greater than about 13, wherein an absolute difference between the HLB index of the first surfactant and the HLB index of the second surfactant is greater than about 3, and wherein the composition forms mixed micelles. | 2011-12-08 |
20110300196 | Method And System For Automatic Or Manual Evaluation To Provide Targeted And Individualized Delivery Of Cosmetic Actives In A Mask Or Patch Form - A system and method are provided for targeted and individualized delivery of multiple skin benefit agents to the skin of a user. The image of a predetermined treatment area of the user's skin is first captured by an imaging device. Selective data input from analysis tools and the end user is then analyzed by a computing device to generate a unique skin profile for the user, which is indicative of the skin conditions at the predetermined treatment area. Based on such skin profile, a printing device prints out one or more cosmetic delivery sheets that can be applied to the predetermined treatment area. Each of the cosmetic delivery sheets contains a substrate with multiple isolate, discrete regions, while at least two of the regions are imprinted with different skin benefit agents for treating different skin conditions of the predetermined treatment area according to the unique skin profile of the user. | 2011-12-08 |
20110300197 | FOOD PRODUCT - The present invention relates to a food product comprising an outer portion and an inner portion, wherein the inner portion comprises myrtle and has a moisture content of from about 10% to about 25% by weight, the food product for use in oral health applications, and the use of the food product in the improvement or maintenance of oral health in an animal, preferably through the reduction or control of tartar and/or dental plaque and/or alteration of the bacterial content of dental plaque, in the oral cavity of the animal. The invention also includes the food product for use in the prevention or treatment of gingivitis in an animal. The invention also provides a method for improving or maintaining oral health in an animal. | 2011-12-08 |
20110300198 | HYDROCOLLOID - ESSENTIAL OIL PATCHES - The present invention relates to dermal patches comprising natural polysaccharides without the need for any pressure sensitive synthetic polymers. Particularly, the present invention relates to patches comprising a bioadhesive composition comprising a polysaccharide exudate and an essential oil useful for transdermal delivery of therapeutic or cosmetic agents. | 2011-12-08 |
20110300199 | PEPTIDES USED IN THE TREATMENT AND/OR CARE OF THE SKIN, MUCOUS MEMBRANES AND/OR SCALP AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS - Peptides of general formula (I): R | 2011-12-08 |
20110300200 | Effect Pigment And The Use Thereof In Cosmetics And In The Foods And Pharmaceuticals Sector - The present invention relates to intensely coloured and light-stable effect pigments based on transparent, undoped SiO | 2011-12-08 |
20110300201 | DELIVERY SYSTEM FOR CO-FORMULATED ENZYME AND SUBSTRATE - The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a water-soluble polymeric matrix and a substrate for the enzyme in a carrier liquid in which the polymeric matrix is insoluble. When water is added, the polymeric matrix is solubilized and enzyme is released from the matrix, permitting catalytic action upon the substrate. | 2011-12-08 |
20110300202 | Medical item for long term durg release - Polymeric articles capable of releasing drugs at therapeutic levels over extended periods of time, and methods for producing the extended release articles. | 2011-12-08 |
20110300203 | CARTILAGE REGENERATION WITHOUT CELL TRANSPLANTATION - Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a cartilage defect. Further provided is a tissue scaffold comprising stromal cell-derived factor-1 (SDF-1) and transforming growth factor-β (TGF-β). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided. | 2011-12-08 |
20110300204 | NUTRITIONAL COMPOSITIONS WITH LARGE LIPID GLOBULE SIZE - The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size, having a volume weighted mode diameter above 1.0 μm and/or with a diameter of 2 to 12 μm in a amount of at least 45 volume % based on total lipid. The composition can be used to increase bone mineral content and/or bone mass density, to prevent osteoporosis and/or osteopenia and for the further prevention of obesity. | 2011-12-08 |
20110300205 | SELF REPLICATING RNA MOLECULES AND USES THEREOF - This application discloses self-replicating RNA molecules that contain modified nucleotides, compositions that contain the self-replicating RNA molecules, and methods for using the self-replicating RNA molecules, for example, to raise an immune response. | 2011-12-08 |
20110300206 | VACCINES AGAINST CHLAMYDIAL INFECTION - The present invention relates to compositions comprising proteins or polynucleotides of | 2011-12-08 |
20110300207 | METHOD OF TREATING POST-SURGICAL ACUTE PAIN - A method is provided for treating pain in patients recovering from post-surgical trauma by administering between about 13 to about 30 mg of diclofenac potassium in a liquid dispersible formulation over a period of at least 24 hours, wherein the daily total amount of diclofenac potassium administered is less than or equal to about 100 mg. The method is particularly useful in treating acute pain in bunionectomy patients. | 2011-12-08 |
20110300208 | SEGMENTED PHARMACEUTICAL DOSAGE FORMS - A pharmaceutical tablet adapted for accurate division of a dose of a drug into two or more smaller doses, which tablet has two or more segments. | 2011-12-08 |
20110300209 | MODIFIED RELEASE SOLID PHARMACEUTICAL COMPOSITIONS OF TRIMETAZIDINE AND PROCESS THEREOF - There is provided a modified release solid pharmaceutical composition comprising Trimetazidine and polyethylene oxide, wherein the composition does not include any lubricant. | 2011-12-08 |
20110300210 | CONTROLLED RELEASE NANOPARTICULATE CLOZAPINE COMPOSITIONS - Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent following administration for a time period ranging from about 2 to about 24 hours or longer. | 2011-12-08 |
20110300211 | SOFT-GELATIN CAPSULE FORMULATION - The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved. | 2011-12-08 |
20110300212 | Pharmaceutical Formulation - The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form. | 2011-12-08 |
20110300213 | Oral formulations of bipolar trans carotenoids - The subject invention relates to a variety of formulations of bipolar trans carotenoids including pharmaceutical compositions for oral delivery of a bipolar trans carotenoid comprising i) a bipolar trans carotenoid, ii) a cyclodextrin, and iii) a coating. The invention also relates to preparation of such formulations and their uses. | 2011-12-08 |
20110300214 | PHARMACEUTICAL COMPOSITIONS COMPRISING 5-CHLORO-N-(-METHYL)-2-THIOPHENCARBOXAMID - The invention relates to pharmaceutical compositions comprising 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid and processes of preparing such compositions. In a second aspect, the present invention relates to a preferred pellet-layering process for preparing such compositions. | 2011-12-08 |
20110300215 | TABLET FORMULATION OF EZATIOSTAT - Disclosed herein are tablets comprising ezatiostat hydrochloride wherein the ezatiostat hydrochloride comprises from about 75 to about 82 percent by weight of the tablet. | 2011-12-08 |
20110300216 | Chewable, swallowable and effervescent solid dosage form for oral delivery of pharmaceutical actives - A tablet comprising: (a) an active ingredient; and (b) at least one member of an effervescent couple, wherein said tablet dissolves in water in not more than three minutes and in the mouth in not more than thirty seconds, and wherein said tablet is capable of acting as an effervescent tablet, a rapid-dissolve tablet or a rapidly disintegrating swallow tablet. | 2011-12-08 |
20110300217 | HYDROMORPHONE THERAPY - A hydromorphone composition, a hydromorphone dosage form and a method for administering hydromorphone are disclosed, indicated for the management of pain. | 2011-12-08 |
20110300218 | NOVEL SOLID STATE FORMS OF RANOLAZINE SALTS - Provided herein are solid state forms of ranolazine salts. Also provided is a stable amorphous form of ranolazine hydrochloride having a water content of less than about 0.5% by weight. Further provided are amorphous co-precipitates of ranolazine or a pharmaceutically acceptable salt thereof with povidone. Processes for the preparation of ranolazine forms, pharmaceutical compositions, and methods of treating thereof are also included. The solid state forms of ranolazine salts are useful for preparing ranolazine in high purity. | 2011-12-08 |
20110300219 | NANOSTRUCTURES FOR DRUG DELIVERY - The present invention provides compositions, preparations, formulations, kits, and methods useful for treating subjects having cancer or at risk of developing cancer. Some embodiments of the invention may comprise a composition comprising a plurality of particles comprising a platinum(IV) therapeutically active precursor. | 2011-12-08 |
20110300220 | SOLID CALCIUM LACTATE IN SUBSTANTIALLY SPHERICAL FORM - Solid calcium lactate in the form of substantially spherical particles, characterised in that the spherical particles have a particle size distribution such that most of the particles are between 280 and 550 microns in size and the calcium lactate can be rapidly dissolved in water. | 2011-12-08 |
20110300221 | Therapeutic Inhibitor of Vascular Smooth Muscle Cells - Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. | 2011-12-08 |
20110300222 | LUMINESCENT POROUS SILICON NANOPARTICLES, METHODS OF MAKING AND USING SAME - The disclosure relates to imaging agents and drug delivery systems. | 2011-12-08 |
20110300223 | IMMUNOGENIC COMPOSITION - An immunogenic composition includes as an effective ingredient an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment is a poly(hydroxy acid), or a particle composed of the antigen-adjuvant microparticle complex associated together, can induce a high immune response against the antigen even with a small amount of the antigen and a small number of doses, so that the immunogenic composition is useful as a vaccine effective for therapy and prophylaxis of infectious diseases, cancer and the like. | 2011-12-08 |
20110300224 | TASTE MASKED DOSAGE FORM OF PHARMACEUTICALLY ACCEPTABLE SALT OF ESCITALOPRAM - A taste masked dosage form of pharmaceutical acceptable salt of escitalopram comprising (a) resin complex of pharmaceutical acceptable salt of escitalopram and cationic exchange resin or adsorbing or coating non-pareil seeds or inert particles with a mixture of pharmaceutically acceptable salt of escitalopram, cationic polymer and optionally other polymer(s) or loading non-pareil seeds or inert particles with pharmaceutically salt of escitalopram followed by polymer coating with cationic polymer and optionally other polymer(s); and (b) at least one pharmaceutical excipient. | 2011-12-08 |
20110300225 | NUTRITIONAL COMPOSITIONS WITH COATED LIPID GLOBULES - The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and/or preventing ostopenia. | 2011-12-08 |
20110300226 | PEPTIDE PARTICLE FORMULATION - A composition as disclosed is comprised of a plurality of groups of particles. The particles are comprised of a biocompatible polymer which maybe a co-polymer such as PLGA combined with a peptide of a sequence of interest, e.g. a sequence which corresponds to a sequence presented on a surface of a cell infected with a virus. A plurality of different groups of particles are provided in the formulation wherein the particles within any single group include peptides of identical amino acid sequence. The particles are sized such that they are sufficiently large so as to prevent more than the contents of a single particle from being presented to a single immune system cell. | 2011-12-08 |
20110300227 | MALIGNANT NEOPLASM TREATMENT PROTOCOL - Methods, compositions, and strategies for the treatment of malignant neoplasms are presented herein. The treatment modalities are directed towards exploiting characteristics of cancer cells as well as correcting defective biochemical pathways and systems in the body. | 2011-12-08 |
20110300228 | COMPOSITION, WITH/WITHOUT AT LEAST ONE EASILY OXIDISED COMPONENT, COMPRISING AN EDIBLE PROCESSED OIL OR FAT MIXTURE, FOR PROMOTING GROWTH IN AN ANIMAL, PREVENTING OXIDATIVE STRESS, AVOIDING THAT FISH DEVELOP ENLARGED LIVER AND FEED COMPOSITION - The present invention relates to a composition for reducing the tendency of an animal to enter sexual maturation, reducing or preventing oxidative damage in an animal, for reducing or preventing oxidative stress in an animal, promoting growth of an animal and for avoiding enlarged liver size in fish. The present invention also relates to a composition having improved characteristics with regard to the stability of easily oxidised components during production and storage; and with regard to the utilization of the easily oxidised components. | 2011-12-08 |
20110300229 | TREATING OR PREVENTING ROTAVIRUS INFECTION - Use of one or more of conjugated linoleic acid (CLA), high CLA milk fat, or one or more bovine milk lipid compositions to treat or prevent rotavirus infection. | 2011-12-08 |
20110300230 | FLUID PURIFICATION SYSTEM - Disclosed are systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process. | 2011-12-08 |
20110300231 | Fluid purification system - Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process. | 2011-12-08 |
20110300232 | EFFECTS OF NITRIC OXIDE (NO) AND iNOS ON EXPRESSION AND SIGNAL TRANSDUCTION IN CANCER AND ITS USE IN DRUG DISCOVERY AND CANCER THERAPY DESIGN - Nitric Oxide (NO) acts as double-edged sword, which induces and prevents cell death, depending on various factors. The mechanism for the NO regulation of cells is not fully understood. The present invention provides experiment design methods and therapy design methods leveraging viable hypothesis supported by current research findings. This invention determines the effects of NO by controlling the majority parameters such as the steady-state concentration of NO, duration of NO exposure and the local level of oxygen. The experiment designs are structured to improve understanding of NO regulation of cells, and further can be directly adapted for therapy design. The invention directs these experiment design and therapy design methods to the study and treatment of cancer. In an application, the effects of exogenous NO on inducible Nitric Oxide Synthase (iNOS) expression and signal transduction in ovarian cancer is applied to drug discovery and therapy design for ovarian and other cancers. | 2011-12-08 |
20110300233 | CONDITIONING COMPOSITION - The present invention is directed to a composition for the conditioning of a dental mineralized surface and/or a dental implant and/or for increasing the hydrophilicity of a dental implant having a metal containing surface. The composition comprises EDTA in a concentration of about 21-55% by weight and hydrogen peroxide at a concentration of about 2-4% by weight. The composition of the invention may be used for the conditioning of mineralized dental surfaces and dental implant surfaces in order to remove e.g. biofilm, debris, bacteria, bacterial toxins etc and/or for increasing the hydrophilicity of an implant having a metal containing surface. The invention is also directed to a kit comprising the composition of the invention and a device to apply the composition to a surface in need of conditioning. | 2011-12-08 |
20110300234 | Methods of Treating Tumor Cells Using RHCC Protein, Fragment or Variant - Methods of treating tumor cells in an individual comprise administering to the individual a drug having anti-tumor effect, wherein the drug is delivered into the tumor cells via Right-Handed Coiled-Coil (RHCC) protein or a fragment or variant thereof. The drug may, for example, be a metal-containing compound, a protein or peptide drug, and/or an organic hydrophobic compound. | 2011-12-08 |
20110300235 | GALLIUM-CONTAINING SEALANT FOR MEDICAL USE - Chronic rhinosinusitis and other bacterial sinus conditions may be treated by applying a solvating system containing a surfactant to a bacterial biofilm in a nasal or sinus cavity, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant. | 2011-12-08 |
20110300236 | Method of treating impaired mitochondrial function - Disclosed in certain embodiments is a pharmaceutical composition comprising a sugar; a Krebs cycle intermediate, precursor of a Krebs cycle intermediate, salt thereof, or combination thereof; and a component selected from the group consisting of an unsaturated lipid, phenylethylamine, a soluble calcium compound, or a combination thereof. | 2011-12-08 |
20110300237 | Protective solutions for organs - Described is a protective solution for avoiding ischemic, storage or ischemia/reperfusion to organs, or to isolated cell systems, or to tissue components after perfusion, surgery, transplantation, or cryopreservation and subsequent reperfusion, which contains alkali ions, and if need be also alkaline earth ions as the electrolyte, a buffer e.g. on a histidine derivation basis, as well as a polyol and/or a saccharide, has an osmolarity of about 290 mosm/l to about 350 mosm/l, as well as a pH value of about 6.8 to about 7.4, and to which hydroxamic acid, and/or one or more hydroxamic acid derivatives are added. | 2011-12-08 |
20110300238 | MIXTURE OF INORGANIC COMPOUNDS, PREPARATIONS CONTAINING THE MIXTURE AND USE OF THE MIXTURE - A mineral mixture including at least' MgO and its equilibrium of Mg(OH) | 2011-12-08 |
20110300239 | BLOOD FLOW IMPROVING AGENT - An object of the present invention to obtain a blood flow improving agent composed of natural components, which increase activity or circulation of blood flow and accelerate decomposition, detoxication and elimination of toxic substances and supplement each other, and the production method thereof. The blood flow improving agent of the present invention is prepared by blending a nano-colloidized marine organic compound, more than one of trace elements containing minerals extracted from a mineral ore and nano-colloidized plant minerals and amino acids derived from a fuvic acid in nano-bubble water containing dissolved oxygen. | 2011-12-08 |
20110300240 | CAJANUS EXTRACTS AND GLUCOSAMINE FOR INFLAMMATORY DISORDERS - The present invention relates to novel compositions comprising | 2011-12-08 |
20110300241 | ORAL CARE COMPOSITIONS FOR TREATING XEROSTOMIA - Disclosed herein are oral care compositions for promoting salivary flow. Thus, also disclosed are methods of treating and preventing xerostomia. The oral care compositions can contain all-natural ingredients, including, for example, green tea polyphenols and | 2011-12-08 |
20110300242 | Novel botanical formulation for treating sickle cell disease - An improved plant medicament composition, comprising a mixture of extractions of Piper guineense, Eugenia caryophyllum and Sorghum bicolor plant material, without the use of Pterocarpus osun stem, for treating sickle cell disease is disclosed. A method for the preparation of said composition is also provided. | 2011-12-08 |
20110300243 | DISINFECTANT MAKING AIR FRESH AND PREPARATION AND METHOD AND USE THEREOF - The air-refreshing disinfectants currently sold in the market mostly contain artificially synthesized chemical disinfectants. Frequent exposure to the air containing such chemicals may be somewhat harmful to the human body. Therefore the present invention provides an air-refreshing disinfectant, and in particular an air-refreshing disinfectant which is not chemically synthesized and takes natural materials as raw materials and traditional Chinese medicinal volatile oils as main effective ingredients. It is characterized by bacteriostatic and antiviral effects, long-lasting fragrance and cost-effectiveness, and is beneficial to human health. To achieve this objective, the present invention, by taking advantage of the bacteriostatic, antiviral and fragrant characteristics of traditional Chinese medicinal volatile oils, employs specific combinations of eucalyptus oil, clove oil, patchouli oil, forsythia oil and schizonepeta oil as the active ingredients of the air-refreshing disinfectant. | 2011-12-08 |
20110300244 | WATER-SOLUBLE EXTRACTS OF ARTEMISIA DRACUNCULUS (TARRAGON) FOR IMPROVEMENT OF GLUCOSE METABOLISM - An extract obtainable by a method comprising the steps extracting Russian Tarragon with water or a mixture of water with up to 20% by volume of a C1 to C3 alcohol. | 2011-12-08 |
20110300245 | Topical, palatable, anti-inflammatory and analgesic for specific application to intraoral, gingival and extraoral areas correlated with, and related to, the trigeminal nerve and its nerve branches and plexus. To mitigate, attenuate or prevent migraine-type headache, cluster-type headache, tension-type headache, post-traumatic headache, atypical facial pain and cervical muscle spasm as well as other idiopathic head or facial pain or discomfort, associated with, or exacerbated by, inflammation - The invention is a new unique, palatable, topical, anti-inflammatory and analgesic designed around a specific set of painful conditions, with specifically designated applications, using a different methodology and formulation, with no NSAIDS, steroids or salicylites, than the prior art for this specific set of painful conditions. Thus creating an improved dissimilar system, preventing the prior arts required invasive, costly and inefficient medical procedures, and with a unique lack of negative effects when compared with the prior art. Thereby, facilitating an anti-inflammatory analgesic effect to areas correlating or relating to the trigeminal nervous system, both intraoral and extraoral. Trigeminal tenderness is noted consistently in many painful conditions and this invention can be used to mitigate these areas of tenderness and inflammation preventing or relieving, migraine, cluster-type headaches, tension-type headache, post-traumatic headache, atypical facial pain and cervical muscle spasm as well as other related pain or discomfort exacerbated by trigeminal inflammation. | 2011-12-08 |
20110300246 | Herbal Extracts for Treatment of Diabetic Complications and Oxidative Stress - Compositions, functional foods, methods of preparation, and their uses for the treatment of diabetic complications and oxidative stress are provided. The compositions, functional foods, and methods relate to herbal extracts from the rhizome of | 2011-12-08 |
20110300247 | FLAXSEED LIGNAN COMPLEX AND ITS USE THEREOF - The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of flaxseed lignans. | 2011-12-08 |
20110300248 | THREE-DIMENSIONAL OBJECT-FORMING APPARATUS - A three-dimensional object-forming apparatus is disclosed, which includes an in-batches powder-rationing tank system, a construction tank system, a printing powder-applying system, a rapid drying heating system, a printing maintenance device, a dust-proof device, a successive liquid-supplying device, a powder auto-filtrating and recycling device, and a print quality detection device. | 2011-12-08 |
20110300249 | LIQUID OR HYDRAULIC BLOW MOLDING - An apparatus for simultaneously forming and filling a plastic container is provided. A mold cavity defines an internal surface and is adapted to accept a preform. A pressure source includes an inlet and a piston-like device. The piston-like device is moveable in a first direction wherein liquid is drawn into the pressure source through the inlet and in a second direction wherein the liquid is urged toward the preform. A blow nozzle may be adapted to receive the liquid from the pressure source and transfer the liquid at high pressure into the preform thereby urging the preform to expand toward the internal surface of the mold cavity and creating a resultant container. The liquid remains within the container as an end product. | 2011-12-08 |
20110300250 | DEVICE FOR FORMING BOX CONTAINERS - Device for forming containers from blanks made of plastic material, having a mold provided with a wall defining a cavity intended to receive the blank; a boxing insert mounted movably with respect to the mold between a retracted position in which the insert is retracted into the wall, and an extended position in which the insert projects from the wall toward the interior of the cavity; a plate, on which the insert is rigidly fixed; a support on which the plate is removably mounted; and a system for the quick attachment of the plate to the support. | 2011-12-08 |
20110300251 | DEVICE FOR THE EXECUTION OF THE OUTPUT OF NANOSCALED POLYMER FIBERS - Carriers for the production and targeted and/or delayed release, particularly of agricultural active substances, as well as a method for the output and a device for the production of such carriers in a loaded or unloaded state are proposed. The method and the device use the technology of electrospinning. | 2011-12-08 |
20110300252 | CONCRETE BLOCK MACHINE HAVING A CONTROLLABLE CUTOFF BAR - An automated concrete block machine including a mold cavity, a feedbox driven between retracted and extended positions and depositing concrete in the mold cavity when at the extended position, a cutoff bar, and a drive system coupled to and driving the cutoff bar in a direction of movement of the feedbox such that a distance between at least a portion of the cutoff bar and a top of the mold varies so that the cutoff bar removes varying amounts of concrete deposited in the mold cavity so that a depth of concrete remaining in at least a portion of the mold cavity varies so as to be unevenly distributed in a desired fashion in the direction of movement of the feedbox. | 2011-12-08 |
20110300253 | PUNCH | 2011-12-08 |
20110300254 | CURVED SURFACE FORMING DEVICE FOR ADJUSTABLE SEGMENTED MOLD BOARD WITH SQUARE RAMS - A curved surface forming device for an adjustable segmented mold board with square rams, consisting of an upper group and a lower group of adjustable molds ( | 2011-12-08 |
20110300255 | FREEZE-DRIED, DAIRY OR DAIRY-SUBSTITUTE COMPOSITIONS AND METHODS OF USING SAME - The present invention comprises a freeze-dried, dairy or dairy-substitute composition comprising a dairy or dairy-substitute ingredient and an emulsifier and methods of using same to promote and/or improve child development. | 2011-12-08 |
20110300256 | CHUNKS IN JELLY FOOD COMPOSITIONS - The invention provides a chunks in jelly food composition comprising chunks in jelly in a chunks to jelly ratio of from about 25:75 to about 60:40, wherein the jelly comprises from about 0.01 to about 1% gellan, from about 0.01 to about 1% deacetylated xanthan, and from about 0.01 to about 1% chelating agent. The jelly maintains its viscosity during the manufacturing process and ensures an even distribution of the chunks in the chunks in jelly food composition. | 2011-12-08 |
20110300257 | METHOD FOR MANUFACTURING A FERMENTATION PRODUCT CONTAINING PROPIONATE AND ACETATE COMPRISING A STEP OF REMOVING CARBONATE-DERIVED COMPOUNDS - A method for manufacturing a mixed solution comprising propionate and acetate includes adding acid to a fermentation product to obtain an acidified fermentation product comprising propionate and acetate with a pH in the range of 2.5 to 8. The method optionally includes removing carbonate-related compounds from the mixed solution. | 2011-12-08 |
20110300258 | COMPOSITIONS SUITABLE FOR BOTRYTIZATION - A highly viable source of conidia of | 2011-12-08 |
20110300259 | BLUE CHEESE PRODUCT AND PROCESS FOR PREPARING SAME - The present invention is directed to a cheese product having a blue cheese flavor and appearance a method of making the same. The method includes generating a coagulum comprising whey and curd from a pasteurized milk product, cutting and stirring the coagulum to release the whey from the curd, draining the whey from the curd, forming an emulsifier, adding the emulsifier to the curd, and pressing the curd into blocks. The emulsifier is preferably formed by blending oil and a paste and heating the oil and the paste. The paste preferably includes, among other ingredients, inert | 2011-12-08 |
20110300260 | METHOD FOR PREPARATION OF FROZEN MICROWAVE INSTANT FOOD - The present invention provides a method for preparation of frozen microwave instant food, wherein the main process is that before being cooked the ingredients are shaped (to ordinary shape or crushing, fine crushing, mashing shape) and impregnated. The impregnating solution used is an aqueous solution containing 30˜150 g/L of trehalose and 1˜100 g/L of polysaccharides, glue, phosphatide, starch, polylactic acid, edible tackifier or edible adhesive Trehalose and polysaccharides, glue, phosphatide, starch, polylactic acid, edible tackifier or edible adhesive, or combination thereof are used to coat the ingredients, thus membranes are formed on the ingredients to improve moisture holding capacity, reduce volatilization, stabilize food structure, inhibit starch retrogradation, protein denaturation, oil decay, unsaturated fatty acid decomposition when the fish being heated, and vegetable and fruit browning, as well as protect the tissue, so that the moisture holding capacity and dry taste of the frozen food are improved. | 2011-12-08 |
20110300261 | Method for the preparation of oil-containing meat-based products comprising a reduced amount of additives - The present invention relates to oil-containing meat-based products, preferably emulsion-type meat-based products, minced or coarsely comminuted meat-based products, pate and fresh (raw) sausages, comprising besides the standard ingredients commonly foreseen for the particular meat-based products a reduced amount of additives selected from emulsifying agents, stabilizing agents and/or thickening agents. Preferably, the oil-containing meat-based products of the present invention contain a maximum of only one single additive selected from emulsifying agents, stabilizing agents and/or thickening agents. More preferably, the meat-based products of the present invention contain no additives, i.e. no emulsifying agents, no stabilizing agents and no thickening agents. Moreover, the present invention pertains to a process for preparing said oil-containing meat-based products. | 2011-12-08 |
20110300262 | LOW CARBOHYDRATE, HIGH PROTEIN, FIBER ENRICHED GELATO FORMULATION AND METHOD OF MANUFACTURE - The present matter provides a gelato formulation that is low in carbohydrate, high in protein, and fiber enriched having similar taste, body and texture of traditional gelatos, and a method of making the same. | 2011-12-08 |
20110300263 | POLYPEPTIDES HAVING CELLOBIOHYDROLASE II ACTIVITY - Provided herein are improved variants of polypeptides having cellobiohydrolase II activity, nucleic acids encoding the polypeptides, vectors, host cells containing the nucleic acids and methods for producing the polypeptides. The polypeptides encompassed by this disclosure may be used in numerous applications including the use of the polypeptides for the production of biofuels and for the synthesis of platform chemicals or biopolymers from renewable sources. | 2011-12-08 |
20110300264 | FROZEN INSTANT BEVERAGE PRODUCT - A method of making a frozen instant beverage product, is carried out by (a) providing a chilled solution, the chilled solution comprising water and a freezing point depressant; (b) mixing the chilled solution with solid particles (e.g., ice particles and flavor particles) to produce a mixture thereof, the mixing step carried out at a temperature at which the frozen ice particles do not melt in the chilled solution; and then (c) forming the paste into the frozen instant beverage product. The frozen instant beverage product can be stored in frozen form for subsequent use, at which time it is combined with one or more beverages to produced a semi-frozen beverage for consumption. | 2011-12-08 |
20110300265 | Pan release compositions for preparation of long shelf life, bakery products - The present invention is directed to methods and compositions for making dough- and batter-based bakery foods, such as bread and cake having extremely long, mold-free and freshness shelf lives, by using a novel antimicrobial pan release agent comprising an essential oil dispersed or dissolved in a fat- or oil-based carrier, along with other natural or chemical antimicrobial agents, anti-staling enzymes, and/or flavor enhancement systems. The invention is also directed to the methods and compositions for preparing all-natural dough- and batter-based bakery products, such as bread and cake having long mold-free shelf lives, by treating the surface of the dough, batter, or baked product with the antimicrobial pan release agent, in conjunction with anti-staling enzymes and natural preservatives in the dough or batter formulations. Further, the invention is concerned with all-natural bakery products having extremely long, mold-free shelf lives which are substantially free (both internally and on the exterior surface) of chemical preservatives and antimicrobial agents other than the all-natural antimicrobial pan release agent and optional natural antimicrobial agents inside the dough. | 2011-12-08 |
20110300266 | ELECTROLYTE BLENDS PROVIDING REDUCED SALTY TASTE - An electrolyte blend is provided having a minimal salty taste in water or other rehydration compositions. One electrolyte blend includes sodium lactate and potassium chloride. An alternate electrolyte blend includes sodium lactate, potassium gluconate, and calcium chloride. The electrolyte blend may be provided as a beverage product, for example a rehydration product containing carbohydrates. In addition, a rehydration beverage composition is provided including water, at least one sweetener, at least one acid, and an electrolyte blend including sodium chloride, sodium lactate, and at least one of potassium chloride, potassium citrate and monopotassium phosphate. An alternate beverage composition is provided including water, at least one sweetener, at least one acid, and an electrolyte blend including sodium chloride, magnesium oxide, calcium lactate, and at least one of potassium chloride, potassium citrate, monopotassium phosphate, sodium lactate and calcium chloride. | 2011-12-08 |
20110300267 | METHOD AND SYSTEM FOR RECOVERING AND PREPARING GLACIAL WATER - Methods and systems for grouping, recovering, and processing ice obtained from an ice source, i.e., a glacier, ice sheet, ice cap, etc., are described herein. In particular, the ice obtained from the ice source is separated and grouped according to common unique properties and processed as a beverage for consumption having the same unique properties. | 2011-12-08 |
20110300268 | Poultry feed and method of making same - A poultry feed in the form of weather resistant blocks or logs with the blocks or logs being comprised of ground dry mature sweet corn, water and whole grain. | 2011-12-08 |
20110300269 | PRETREATED DENSIFIED BIOMASS PRODUCTS AND METHODS OF MAKING AND USING SAME - A product comprising at least one densified biomass particulate of a given mass having no added binder and comprised of a plurality of lignin-coated plant biomass fibers is provided, wherein the at least one densified biomass particulate has an intrinsic density substantially equivalent to a binder-containing densified biomass particulate of the same given mass and h a substantially smooth, non-flakey outer surface. Methods for using and making the product are also described. | 2011-12-08 |
20110300270 | COOKING DEVICE AND METHOD OF MEAL PREPARATION - A pre-loadable cartridge for retaining and dispensing of ingredients of a meal to be subsequently cooked, the cartridge including an ingredient separating portion of at least two compartments, one for solid ingredient and one for liquid ingredient. Also includes is a base portion that together with the ingredient separating portion defines a receptacle for retaining said ingredients in each compartment. The ingredient separating portion and base portion are moveable relative to each other. Each compartment includes a first aperture, and the base portion includes at least one second aperture, such that in use, the ingredient separating portion is able to be moved relative to the base portion to allow the first aperture of each compartment to be moved into operable communication with at least one second aperture to provide an outlet passage for ingredient in each compartment from the cartridge through the base portion. | 2011-12-08 |
20110300271 | NOVELTY SEALED FOOD PRODUCTS AND METHOD OF MANUFACTURE OF SAME - An apparatus and method for manufacturing a novelty sealed food product having a complex shape. The apparatus including an anvil plate and an ultrasonic horn that seals a filling within a pair of food substrates with an ultrasonic vibration and without a sealing additive, such as a carbohydrate or a hydrocolloid. | 2011-12-08 |
20110300272 | Microwave-Refrigerator Unit - Microwave-refrigerator units are disclosed. In one aspect, a microwave-refrigerator unit may include a weatherproof exterior. A microwave may be included within the weatherproof exterior. A refrigerator may also be included within the weatherproof exterior. The refrigerator may be coupled with the microwave. Other microwave-refrigerator units are also disclosed, as are methods of using microwave-refrigerator units. | 2011-12-08 |
20110300273 | Non-Porous Moisture and Gas Permeable Films - Disclosed are moisture and gas permeable films which can comprise or be obtained from a blend of a polyamide with a potassium-containing ionomer of an ethylene acid copolymer, an ethylene ester dipolymer, and optional compatibilizer selected from dicarboxylate-containing polymers and ethylene glycidyl ester copolymers. The films are suitable for preparation of tubular casings and shrinkbags, in particular, casings for smoked foodstuffs. | 2011-12-08 |
20110300274 | Wild bird feed and method of making same - A wild bird feed is disclosed which is comprised of ground dry mature sweet corn, water and wild bird feed. | 2011-12-08 |
20110300275 | WATER PURIFYING AND FLAVOR INFUSION DEVICE - A water purifying and flavor infusion device that includes a lower reservoir for storing filtered water, and a pitcher top removably affixed to the lower reservoir. The pitcher top includes a lid, an upper reservoir, and a filter housing affixed to and extending below the upper reservoir. The filter housing is adapted to contain a filter cartridge wherein the upper reservoir and the filter housing are in liquid communication. The device also includes an infusion tube for infusing filtered water with an additive. | 2011-12-08 |
20110300276 | PROCESS OF BREWING TEA LEAVES CONTAINED IN A CAPSULE - The invention concerns a process for the preparation of a beverage in a beverage machine with a capsule comprising an enclosure containing tea leaves comprising the steps of: a) introducing water in the capsule to submerge the tea leaves in the capsule enclosure, then b) introducing water at a soaking flow of at most 80 ml/min, then c) introducing water in the capsule until the required volume of beverage is delivered, wherein during at least one period of step b), water is introduced in the capsule at least once at a stirring flow superior the soaking flow to stir tea leaves. | 2011-12-08 |
20110300277 | Cooking Apparatus And Related Method - This invention provides a pot for frying or boiling, which comprises a pot having at least one side wall. The side wall defines an opening at a level proximate to a top portion of the side wall, and a conduit sealably connected to the opening and extending outward from the side wall. The conduit has a first end defined by the opening and a second end defining an outlet. An interior volume defined by the pot is in fluid communication with the conduit. An apparatus capable of sealably attaching to a pot for frying or boiling is also disclosed. | 2011-12-08 |
20110300278 | Central Vacuum Cooling Plant - Described is a method as well as an apparatus for vacuum cooling of food produce through moisture removal, which method comprising the steps of loading the food produce to be cooled into a vacuum chamber, lowering the pressure inside the vacuum chamber to a predetermined pressure level and maintaining the vacuum chamber at this predetermined pressure level both by removing air through a vacuum pump system for a sufficient of time to allow heat transfer out of the food produce to take place, and condensing water vapor inside the vacuum chamber through a refrigeration system. The method and apparatus is unique in that the step of lowering the pressure inside the vacuum chamber to the predetermined pressure level is carried out using a single stage vacuum pump and the step of maintaining the vacuum chamber at this predetermined pressure level is carried out using a two stage vacuum pump. | 2011-12-08 |