50th week of 2009 patent applcation highlights part 45 |
Patent application number | Title | Published |
20090305217 | COMPUTERIZED EDUCATIONAL RESOURCE PRESENTATION AND TRACKING SYSTEM - A computerized educational resource presentation and tracking system is provided. The system includes a collection of stored educational resources organized according to user accounts for each of a plurality of users, a presentation application configured to present at least some of the collection of stored educational resources at a client device of each of the plurality of users. The presentation application may include an educational resource module configured to create a modified version of a specified educational resource in response to receiving a user-generated edit of the specified educational resource, the modified version having metadata to link to a previous version of the specified educational resource. The presentation application may further include a presentation generator configured to generate a presentation of a user-selected subset of the collection of educational resources including the modified version of the specified educational resource, ordered in a user-specified presentation order. | 2009-12-10 |
20090305218 | Object-Based System and Language for Dynamic Data or Network Interaction Including Learning Management - A system including an object-oriented programming language for building state-based applications with flow control, event loops, measures of similarity, and Boolean logic to dynamically control the interaction between members in a social network around content and, in particular, project-based activities, where the system collects and groups individuals who are members of a social network, projects or assignments and their content, and activities or processes within projects based on the attributes of the objects and runtime events to create a social context for learning or for other interaction. | 2009-12-10 |
20090305219 | APPARATUS, AND ASSOCIATED METHOD, FOR PROVIDING PERSONALIZED CONTENT TO AN EXHIBIT-AREA GUEST - An apparatus, and an associated method, for providing personalized content to a guest at an exhibit area. Content is collected and stored that is associated with exhibits of the exhibit area. The exhibit content is formed of content portions that are tagged with identifiers. The identifiers correspond with categories of guest, demographic information. When a guest enters the exhibit area, demographic information associated with the guest is used to create personalized content that is played out to the guest by way of a guest device carried by the guest when the guest is detected by an exhibit node detector to be in vicinity of an exhibit. | 2009-12-10 |
20090305220 | Gas Monitor Training System - A gas monitor training system for efficiently providing interactive and simulated training for individuals who are to utilize a portable gas monitor. The gas monitor training system generally includes an instructor computer, a database connected to the instructor computer, wherein the database includes information to be edited by the instructor computer and at least one training device, wherein the at least one training device receives the information of the database and wherein the training device transmits the information to a student. The information is comprised of messages commonly displayed upon a gas detection monitor and is also generally communicated between the training device and the portable computer via the network. | 2009-12-10 |
20090305221 | Hybrid E-Learning Course Creation and Syndication - The disclosed invention is directed to a method and system which allows publishers to create hybrid elearning courses and to publish the courses to a variety of environments including to an LMS, a web interface, or a CD-ROM. Through a “syndication” process, the hybrid elearning courses are associated with consuming organizations downstream of the publisher; such consuming organizations and/or roles within such organizations may be allowed to edit or customize those portions of the courses which have been labeled as “consumer editable.” | 2009-12-10 |
20090305222 | Organ Preservation Solution - The invention relates to the field of organ and biological tissue preservation and in particular to solutions for use in preserving organs and/or tissues prior to transplanting into a subject. | 2009-12-10 |
20090305223 | METHOD AND APPARATUS FOR EVALUATIING INTERACTIONS IN ISOLATED TISSUE - An apparatus for evaluating the effects of stimuli on tissue includes an environment for holding at least a sample of the tissue from a living person. The apparatus also has a first source connected to the environment for delivering nutrients to the tissue to maintain the tissue in a viable condition for more than one week. A second source is connected to the environment for delivering a biologically active agent to the tissue. The biologically active agent is capable of inducing carcinogenesis in the tissue when metabolized. An effluent outlet is connected to the environment to remove effluent from the environment. | 2009-12-10 |
20090305224 | Methods for the Cryopreservation of Mammalian Cells - The present invention features novel methods for the cryopreservation of mammalian cell that combine the advantages of the slow-freezing and vitrification approaches while avoiding their shortcomings. Generally, the methods include the use of a capillary tube made of a thermally conductive wall material and a thin wall such that the ratio of the thermal conductivity of the wall material to the wall thickness is at least 1,000-500,000. The solution is then exposed to temperatures equal to or less than −80° C. and the vitrification solution containing the mammalian cells is cooled at a rate equal to or greater than 30,000-100,000,000° C./minute. The exposure of the capillary tube with a thermally conductive and thin wall allows for vitrification of the solution in the absence of ice formation. Cryoprotectants can also be added to the vitrification solution to further prevent ice formation. | 2009-12-10 |
20090305225 | Inhibition of Creatine Uptake to Promote Weight Loss - The present invention provides a method of promoting weight loss, or treating or preventing a body disorder related to excess weight, in a subject. The method comprises administering to the subject an effective amount of a creatine uptake inhibitor. Administration of the creatine uptake inhibitor is intracranial or directed to the hypothalamus. The invention further provides a method of screening for a novel compound that inhibits creatine uptake in the hypothalamus. | 2009-12-10 |
20090305226 | Biomolecular Recognition of Crystal Defects - Discrete and diffuse defects in a surface are detected. Discrete defects that may compromise the performance may be repaired. | 2009-12-10 |
20090305227 | HIV-1 LATENCY MODEL FOR HIGH THROUGHPUT SCREENING - Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I derived vector pro virus, which upon activation expresses a marker for late viral gene expression due to the insertion of the marker gene in the position of HIV-I envelope. | 2009-12-10 |
20090305228 | Potentiation of Apoptosis by Monoclonal Antibodies - The present invention relates to the use of an antibodies composition, the fucose content of which is less than 65%, for indicating apoptosis in vitro. | 2009-12-10 |
20090305229 | MULTIPLEX DETECTION OF RESPIRATORY PATHOGENS - Described are kits and methods useful for detection of respiratory pathogens (influenza A (including subtyping capability for H1, H3, H5 and H7 subtypes) influenza B, parainfluenza (type 2), respiratory syncytial virus, and adenovirus) in a sample. Genomic sequence information from the respiratory pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in a sample. Primer and probe sets were designed and optimized for use in a PCR based, multiplexed Luminex assay to successfully identify the presence or absence of pathogens in a sample. | 2009-12-10 |
20090305230 | Real Time Detection of Molecules, Cells and Particles Using Photonic Bandgap Structures - Provided herein is a photonic bandgap (PBG) detector effective to detect inorganic molecules, organic biomolecules or biopolymers, cells, subcellular organelles, and particles. The PBG detector utilizes photonic crystals having a binding agent attached to channel surfaces comprising the crystals to selectively bind a molecule, cell or particle of interest so that an increase in light transmission is detectably induced within the photonic bandgap upon binding. Also provided are methods of optically detectiing an analyte and of identifying the presence of a cell or a particle in a biological sample. | 2009-12-10 |
20090305231 | Sensitive Immunoassays Using Coated Nanoparticles - Coated nanoparticles comprising a core surrounded by a shell that increases the reflectance of the nanoparticle, wherein the coated nanoparticle does not include a Raman-active molecule, are provided. Test devices and immunoassay methods utilizing the coated nanoparticles are provided. | 2009-12-10 |
20090305232 | Peptides for Detection of Antibody to Porcine Reproductive Respiratory Syndrome Virus - The invention provides compositions and methods for the detection and quantification of PRRSV antibodies and antibody fragments using polypeptides. | 2009-12-10 |
20090305233 | Methods and Reagents for Polynucleotide Assembly - The present invention provides methods, compositions, and kits for polynucleotide assembly. | 2009-12-10 |
20090305234 | Specific DNAS for Epigenetic Characterisation of Cells and Tissues - The present invention provides methods, nucleic acids and molecular markers for the characterization of cells, tissues and heterogeneous mixtures of cells. Specifically, it describes particular genes and genomic regions in which DNA methylation patterns are a consistent and characteristic property of different cell types, states and stages of differentiation. The invention is useful in determining the identity, composition, quality and potency of cells and cell populations. Furthermore, the invention will be useful in monitoring the differentiation of cells. | 2009-12-10 |
20090305235 | Novel Targets For The Identification Of Antibiotics That Are Not Susceptible To Antibiotic Resistance - To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for pharmaceuticals that are taxonomically specific and which are refractory to the development of drug resistance. | 2009-12-10 |
20090305236 | METHODS OF ENRICHING FETAL CELLS - The present invention relates to methods of enriching fetal cells from a pregnant female. The present invention relates to removing, from a sample, cells that comprise at least one MHC molecule. The present invention also relates to methods that rely on using telomerase, mRNA encoding components thereof, as well as telomere length, as markers for fetal cells. Enriched fetal cells can be used in a variety of procedures including, detection of a trait of interest such as a disease trait, or a genetic predisposition thereto, gender typing and parentage testing. | 2009-12-10 |
20090305237 | QUANTIFICATION OF NUCLEIC ACIDS AND PROTEINS USING OLIGONUCLEOTIDE MASS TAGS - The invention provides a method for detecting and quantifying the amount of target molecules, such as nucleic acids or proteins in a sample. The target molecules are first recognized and bounded by target-specific probes, generally nucleic acids or proteins that bind specifically to the targets, each of which is labeled with a short single-stranded nucleic acid probe, either DNA or RNA, with distinct molecular weight. This label is called an oligonucleotide mass tag. One or several standard oligonucleotide sequences can be designed with similar sequence but distinct molecular weight to those oligonucleotide mass tags. Then the oligonucleotide mass tags associated with bounded probes and the standard sequences are co-amplified using a pair of common primers. The presence and/or amount of each oligonucleotide mass tag, which corresponds to the amount of corresponding target molecule, is determined by a primer extension reaction and quantification of the primer extension product. | 2009-12-10 |
20090305238 | Microarray Microcard - A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided. | 2009-12-10 |
20090305239 | Methods and compositions for determing a level of biologically active serum paraoxonase - A method of determining a level of biologically active PON enzyme is provided. The method comprising determining lactonase activity of the PON enzyme, the lactonase activity being indicative of the level of biologically active PON enzyme. Also provided are novel compounds which may be used for measuring a lactonase activity of an enzyme. | 2009-12-10 |
20090305240 | METHOD FOR DETECTION OF MICROORGANISM AND KIT FOR DETECTION OF MICROORGANISM - Live cells of a microorganism in a test sample are detected by the following steps:
| 2009-12-10 |
20090305241 | DNA demethylases and uses thereof - Polypeptides with DNA demethylase activity as well as methods of their use are provided. | 2009-12-10 |
20090305242 | SKIN AGING MARKER AND TECHNIQUE FOR USE THEREOF - It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging. | 2009-12-10 |
20090305243 | Oligonucleotides, Use Thereof, Detecting Method and Kit for Diagnosing the Presence of H5 and N1 Genes of the Influenza a Virus - The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said oligonucleotides being of a length ranging between 10 and 50 nucleotides and comprising at least one fragment of 10 consecutive nucleotides derived from the following sequences: | 2009-12-10 |
20090305244 | Selection, Propagation and Use of Mosaic Aneuploid Stem Cells - The distribution of cell karyotypes within a population of cells can determine the phenotype and ability of stem cells to differentiate into desired cell types, to function normally, as well as represent risk for adverse events like cancer. Therefore, determination of the aneuploid mosaic status of a cell population is useful in identifying and/or maintaining desirable traits and eliminating undesirable traits in stem cells, and for defining them at the level of their chromosomal complement. | 2009-12-10 |
20090305245 | Method of Examining Zinc-Deficient Taste Disturbance - The present invention provides: a method for testing zinc deficiency dysgeusia, which is characterized in that it comprises correlating the expression levels of a gene encoding a gustatory receptor belonging to the THTR family and a gene encoding a gustatory receptor belonging to the T2R family obtained from a sample derived from the oral cavity of a subject, with a serum zinc level obtained from the sample of the subject; and a kit used for the aforementioned test. | 2009-12-10 |
20090305246 | SCHIZOPHRENIA ASSOCIATED GENES AND MARKERS - The invention discloses schizophrenia-associated polymorphism located on chromosome 6q23 within the human Abelson Helper Integration Site 1 gene (AHI1), or a genomic region linked to the AHI1 gene that includes the C6orf217 gene. The invention further discloses systems and methods for diagnosing schizophrenia or predisposition to schizophrenia. | 2009-12-10 |
20090305247 | NANOPARTICLE AND METHODS THEREFOR - There is provided an electroactive nanoparticle, which may be used as a label in electrochemical detection assays. The nanoparticle comprises a transition metal oxide and a capping agent, the capping agent comprising a ligand group and a functional group. The capping agent is coordinated to a transition metal centre in the transition metal oxide via the ligand group. Also provided are methods relating to preparation of the nanoparticle and detection of an analyte molecule in a sample using electrochemical methods. | 2009-12-10 |
20090305248 | METHODS FOR INCREASING ACCURACY OF NUCLEIC ACID SEQUENCING - The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template. | 2009-12-10 |
20090305249 | METHOD OF DETECTING CYP2A6 GENE VARIANTS - The present invention relates to methods for amplifying various regions of the CYP2A6 gene. Methods are provided for amplifying one or more fragments of the CYP2A6 gene in a single tube. The methods can identify mutations, deletion, duplication, and/or rearrangement in a sample containing the CYP2A6 gene. | 2009-12-10 |
20090305250 | DETERMINATION OF THE BIOLOGICAL FUNCTION OF A TARGET GENE IN A CELL - Disclosed herein is a method to determine the biological function(s) of a target gene in a cell, the steps of which involve separately culturing a first population and a second population of the cell under same culturing conditions, the first population of the cell differing from the second population of the cell in that the first population of the cell has accepted the introduction of a methylated polynucleotide; comparing the first population and the second population of the cell to determine which biological difference(s) is/are present therebetween; and determining which biological function(s) the target gene is associated with based on the determined biological difference(s) between the first population and the second population of the cell. | 2009-12-10 |
20090305251 | BRCA1/BRCA2 SCREENING PANEL - A method for analyzing a biological sample is performed by analyzing a biological sample for the presence of one or more mutations or polymorphisms in the BCRA1 and/or BCRA2 genes. | 2009-12-10 |
20090305252 | Methods and species-specific primers for detection and quantification of Streptococcus mutans and Streptococcus sanguinis in mixed bacterial samples - Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the | 2009-12-10 |
20090305253 | Methods and Compositions Related to the Modulation of Riboswitches - Disclosed herein are methods and compositions related to the detection of conformational changes and interactions with trigger molecules in riboswitches. | 2009-12-10 |
20090305254 | Method and Apparatus for Assaying Test Substance in Sample - Disclosed are a method for assaying a target substance in a sample and an apparatus for the method. The method can specifically assay the target substance in the sample without using any antibody against the target substance. The assaying method includes simultaneously or successively bringing a labeled aptamer, the target substance in the sample and a solid phase into contact together, and then measuring the label of the aptamer which has not been bound on the solid phase. The labeled aptamer has a property of binding to the target substance. The solid phase carries an oligonucleotide immobilized on it in an excess amount relative to the target substance. The oligonucleotide is hybridizable with the labeled aptamer when the labeled aptamer is in a state that it is not bound to the target substance, but is not hybridizable with the labeled aptamer when the labeled aptamer is in a state that it is bound to the target substance. | 2009-12-10 |
20090305255 | Substrate Protein for M-Phase Kinase and use Thereof - An isolated protein of (a) a protein having an amino acid sequence of SEQ ID No. 2; (b) a protein having an amino acid sequence partially different from the amino acid sequence of SEQ ID No. 2 that is a substrate of M-period kinase and has nucleic acid-methylating activity suppressed by phosphorylation; (c) a protein having the amino acid sequence of SEQ ID No. 2 that is phosphorylated by M-period kinase; or (d) a protein having an amino acid sequence partially different from the amino acid sequence of SEQ ID No. 2 that is phosphorylated by M-period kinase. | 2009-12-10 |
20090305256 | DNA methylation biomarkers for lung cancer - The present invention relates to the identification of novel DNA biomarkers and the use of the aberrant methylation patterns of the biomarkers to diagnose a disease or a condition (e.g., a cancer) associated therewith. In particular, the present invention relates to the use of the novel DNA biomarkers to diagnose lung cancers, e.g., squamous cell carcinomas and adenocarcinomas. | 2009-12-10 |
20090305257 | BIOMARKERS DOWNREGULATED IN PROSTATE CANCER - Biomarkers are identified by analyzing gene expression data using support vector machines (SVM), recursive feature elimination (RFE) and/or linear ridge regression classifiers to rank genes according to their ability to separate prostate cancer from normal tissue. Proteins expressed by identified genes are detected in patient samples to screen, predict and monitor prostate cancer. | 2009-12-10 |
20090305258 | METHODS FOR THE DIAGNOSIS OF PROLIFERATIVE AND/OR CONFORMATIONAL DISEASES - The present invention discloses methods to diagnose and/or to make prognostic predictions and/or to monitor the efficacy of a therapy of a proliferative or conformational disease, or to establish the state of ageing in a subject. Kit for performing such methods are also disclosed. | 2009-12-10 |
20090305259 | Early Diagnosis of Congenital Abnormalities in the Offspring of Diabetic Mothers - The present invention relates to the identification of a series of biomarkers, the detection of which is prognostic for women at risk of becoming hyperglycemic during pregnancy and/or fetuses at risk of developing congenital anomalies as a result of maternal hyperglycemia. | 2009-12-10 |
20090305260 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 59 to 61 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2009-12-10 |
20090305261 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 65 to 67 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2009-12-10 |
20090305262 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 56 to 58 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2009-12-10 |
20090305263 | PROBE, PROBE SET, PROBE-IMMOBILIZED CARRIER, AND GENETIC TESTING METHOD - A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 43 to 45 or a combination of at least two of them is used for detecting the gene of an infectious disease pathogenic bacterium. | 2009-12-10 |
20090305264 | COOPERATIVE PROBES AND METHODS OF USING THEM - The present invention provides inter alia, cooperative probe assays for analyzing and identifying biological substances. | 2009-12-10 |
20090305265 | INTERLEUKIN-33 (IL-33) FOR THE DIAGNOSIS AND PROGNOSIS OF CARDIOVASCULAR DISEASE - The present invention includes methods for the use of interleukin-33 (IL-33) in the diagnosis of cardiovascular conditions including acute coronary syndrome (ACS), myocardial infarction, and/or heart failure, angina, cardiac hypertrophy, arteriosclerosis, myocarditis, pancarditis, endocarditis, stroke and/or pulmonary embolism and the determination of the severity of such conditions (prognosis). | 2009-12-10 |
20090305266 | TEST FOR OVARIAN CANCER BY DETECTING ABNORMALITY IN FANCD2 PATHWAY - Methods are provided for determining diagnosing ovarian and breast cancer in a subject, including diagnosing the predisposition of a subject's risk of developing breast or ovarian cancer. The methods include selecting a subject, for example a subject with one or more risk factors for developing ovarian cancer or breast cancer, and detecting a decrease in the activity of the Fanconi anemia (FA) non-nuclear core (NNC) component in the subject. Such a decrease is indicative of a predisposition to ovarian cancer and/or breast cancer in the subject. These methods can be used to monitor the response of a subject to agents designed to prevent breast and ovarian cancer, for example an anti-neoplastic agent. Methods also are provided for identifying agents of use in preventing breast and ovarian cancer. | 2009-12-10 |
20090305267 | MICROBIAL MARKERS OF INFLAMMATORY BOWEL DISEASE - The present invention relates to bacterial serine protease autotransporter (SPATE) and Antigen 43 (Ag43) and their various uses relating to inflammatory bowel disease (IBD), specifically in the diagnosis of IBD and the screening of potential agent for treating IBD. The invention also relates to methods for cultivating and identifying enteric microbes. | 2009-12-10 |
20090305268 | METHOD OF DETERMINING AN AMOUNT OF FATTY ACID CONTENTS IN BOVINE INTRAMUSCULAR FAT ON THE BASIS OF GENOTYPE OF FATTY ACID SYNTHASE GENE AND METHOD OF DETERMINING GOODNESS OF EATING QUALITY OF BEEF ON THE BASIS OF THE RESULTS THEREOF - The present invention has an object to provide a method of determining fatty acid composition in intramuscular fat on the basis of bovine genotype, in particular a method of simply determining an amount of an oleic acid content with a high degree of accuracy, and a method of objectively determining the goodness of eating quality of beef on the basis of the results of the determination. The present invention provides a method of determining an amount of fatty acid content in bovine intramuscular fat on the basis of the genotype of fatty acid synthase determined by determining base <1> and/or base <2> described below, and a method of determining whether cattles are those from which beef with an excellent eating quality is obtained on the basis of the results thereof. | 2009-12-10 |
20090305269 | PCR SCREENING METHOD - A tooling system ( | 2009-12-10 |
20090305271 | In Vitro Assay Based on Camp Levels Modulated by Gi-Coupled Receptors - The present invention relates to a reliable and effective in vitro assay based on cAMP levels modulated by Gi-coupled receptors expressed in a selected cell for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor. | 2009-12-10 |
20090305272 | METHOD OF CHARACTERIZING ENDOGENOUS POLYNUCLEOTIDE-POLYPEPTIDE INTERACTIONS - A method for characterizing an endogenous polypeptide includes introducing epitope tag-encoding polynucleotide into an endogenous locus of a somatic cell by homogenous recombination mediated knock-in so that an epitope tagged endogenous polypeptide is expressed by the cell, and characterizing the epitope tagged endogenous polypeptide using an immunoassay. | 2009-12-10 |
20090305273 | NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS - Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices. | 2009-12-10 |
20090305274 | Method for determining azole resistance in candida glabrata - There is disclosed a method for determining azole resistance in | 2009-12-10 |
20090305275 | DNAs AND PROTEINS OR PEPTIDES SPECIFIC TO BACTERIA OF THE SPECIES NEISSERIA MENINGITIDIS, PROCESS FOR OBTAINING THEM AND THEIR BIOLOGICAL USES - The DNA of the invention are characterised in that they concern the whole or pan of genes, with their reading frame, to be found in | 2009-12-10 |
20090305276 | Method for Predicting Skin Sensitizing Activity of Compounds - The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3 LLNA value, a GPMT value or a IVTI value—without the use of animals, with a high degree of accuracy. The methods involve detecting expression levels of genes implicated in skin sensitization, combining expression level data with concentration response data, conducting a computational analysis, and comparing test compound data to a database of known skin sensitizers. | 2009-12-10 |
20090305277 | GENE EXPRESSION MARKERS FOR PREDICTION OF PATIENT RESPONSE TO CHEMOTHERAPY - The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment of prognosis and/or prediction of patient response to chemotherapy, using expression analysis. The present invention accommodates the use of archived paraffin embedded biopsy material for assay of all markers in the relevant gene sets and therefore is compatible with the most widely available type of biopsy material. | 2009-12-10 |
20090305278 | SEQUENCE DETERMINATION IN CONFINED REGIONS - A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system. | 2009-12-10 |
20090305279 | METHOD OF DIAGNOSIS - Provided are methods, kits and arrays for use in determining whether a scar of interest is keloid or non-keloid in nature. These determine keloid or non-keloid nature based on comparison of gene expression in the scar of interest with expression in a control sample. If expression of at least one gene, selected from the group of genes set out in Table 1, is decreased in a sample representative of gene expression in the scar of interest compared to expression of the same gene (or genes) in the control sample this indicates that the scar of interest comprises a keloid. | 2009-12-10 |
20090305280 | Luciferase biosensors for camp - A modified luciferase protein which is a sensor for molecules including cAMP is provided. The modified luciferase protein includes one or more heterologous amino acid sequences, at least one of which directly or indirectly interacts with cAMP. | 2009-12-10 |
20090305281 | NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTACE - Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure. | 2009-12-10 |
20090305282 | NOVEL HUMAN VIRUS CAUSING RESPIRATORY TRACT INFECTION AND USES THEREOF - The present invention provides the complete genomic sequence of a novel human coronavirus, coined as coronavirus-HKU1 (“CoV-HKU1”), isolated in Hong Kong from a patient who had a recent history of visit to Schenzhen. China. The virus belongs to the order Nidovirales of the family Coronavirdae, being a single-stranded RNA virus of positive polarity. The invention also provides the deduced amino acid sequences of the complete genome of the CoV-HKU1. The nucleotide sequences and deduced amino acid sequences of the CoV-HKU1 are useful in preventing, diagnosing and/or treating the infection by CoV-HKU1. Furthermore, the invention provides immunogenic and vaccine preparations using recombinant and chimeric forms as well as subunits of the CoV-HKU1 based on the nucleotide sequences and deduced amino acid sequences of the CoV-HKU1. | 2009-12-10 |
20090305283 | CLEAVAGE OF NUCLEIC ACIDS - The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof. | 2009-12-10 |
20090305284 | Methods for Identifying Risk of Breast Cancer and Treatments Thereof - Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome. | 2009-12-10 |
20090305285 | ASYMMETRIC CYANINE COMPOUNDS, THEIR PREPARATION METHODS AND THEIR USES - Asymmetric cyanine compounds represented by general formula I are provided, wherein X, n, R | 2009-12-10 |
20090305286 | Method for the Identification of Suitable Fragmentation Sites in a Reporter Protein - The invention concerns a combinatorial method for the generation of new split-protein sensors, and its application towards the (β/α) | 2009-12-10 |
20090305287 | Method and System for Multiplex Genetic Analysis - A method for identifying nucleotides in a nucleic acid sequence is disclosed. A plurality of polymerization complexes are provided within a plurality of confined reaction environments. Each complex comprises a polymerase enzyme and a template nucleic acid. The plurality of complexes are contacted with a plurality of types of nucleotide analogs labeled with distinguishable fluorescent labels under conditions suitable for polymerization. Fluorescent signals associated with incorporation of a nucleotide analog are transmitted to a detector, wherein the location of the fluorescent signal on the detector is indicative of the individual confined reaction environment and the type of nucleotide incorporated. The nucleotide in a nucleic acid sequence is identified based upon the type of nucleotide incorporated and the confined reaction environment. | 2009-12-10 |
20090305288 | METHODS FOR AMPLIFYING NUCLEIC ACIDS AND FOR ANALYZING NUCLEIC ACIDS THEREWITH - An object of the present invention is to control the increase in amplification errors generated during the nucleic acid amplification and thus to obtain an amplification product having a good reproducibility. The present invention is characterized in that a target nucleic acid to be amplified is amplified through a two-stage amplification process in which the amplification only of a single strand is first performed and a strand which is complementary to its amplified product is then amplified. The amplification uses a first primer which is employed for the first-stage amplification and a second primer which is employed for the second-stage amplification. These primers are each used separately, or alternatively designed to have a different stringency and used at the same time. | 2009-12-10 |
20090305289 | SCREENING METHOD TO IDENTIFY PROTECTIVE SUBSTANCES FOR THE TREATMENT OF NEURODEGENERATIVE AND/OR ISCHAEMIC DISEASES - The present invention relates to a screening method for the identification of protective substances which influence haemoglobin formation in neuronal, myocardial and/or skeletomuscular cells, as well as to recombinant constructs, host cells and transgenic animals for the implementation of this method. In addition, the present invention relates to a diagnostic method for the differential diagnosis of neurodegenerative and/or ischaemic diseases in mammals and the use of haemoglobin, a globin or a mutein or fusion protein thereof or a corresponding nucleic acid for the treatment of neurodegenerative and/or ischaemic diseases in mammals. The invention furthermore relates to constructs for gene therapy of such diseases. | 2009-12-10 |
20090305290 | LATERAL FLOW NUCLEIC ACID DETECTOR - Point-of-care binding assays include at least one target nucleic acid binding in a multiplex structure with at least one sequence in a partner nucleic acid associated with a label, due to complementary base pairings between at least one sequence in the target nucleic acid and at least one sequence in the partner nucleic acid. The assays overcome the inherent deficiencies of antibody-protein antigen assays. In a preferred embodiment, color tagged nucleic acid sequences are used to bind a complementary target nucleic acid. The tagged nucleic acid sequences are preferably made from deoxyribonucleotides, ribonucleotides, or peptide nucleotides. | 2009-12-10 |
20090305291 | METHOD AND A MICRODEVICE FOR THE IDENTIFICATION AND/OR QUANTIFICATION OF AN ANALYTE IN A BIOLOGICAL SAMPLE - A method and device, based on a film of a luminescent substance, such as colloidal semiconductor nanocrystals dispersed in a polymer matrix, for conducting quantitative and real-time analyses of PCR processes or of biomolecular interactions in genomics and/or proteomics. The optical detection system is based on FRET processes between the luminescent substance (which acts as the donor in the FRET process) and a suitable fluorophore (which acts as the acceptor species) with which the DNA or other biomolecule is marked. The device is essentially composed of a reaction microchamber with a wall formed by a thin film made of polymer material, in which the nanocrystals are uniformly dispersed, or made of a photoluminescent or electroluminescent polymer. Molecular probes are chemically immobilized on the surface of the polymer film for the specific recognition of the analyte which is to be determined in real time. The film of nanocrystals is excited by radiation at low wavelength (for example, UV/blue), and the radiation in the spectral emission window characteristic of the fluorescent marker of the biomolecule is detected. The specific photophysical characteristics of FRET processes make it possible to monitor in a selective way, in real time and in quantitative mode, the biomolecular interactions, which take place in the close proximity of the surface of the film (typically at distances of <10 nanometres), thus almost completely reducing possible interference caused by background signals and by the free biomolecules in solution (which have not interacted with the corresponding recognition sites). The characteristics of the device also enable simultaneous analyses to be conducted in parallel on different biomolecules (multiplexing). | 2009-12-10 |
20090305292 | DNA POLYMERASE - The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described. | 2009-12-10 |
20090305293 | COMPOSITIONS AND METHODS TO DETECT CANDIDA ALBICANS NUCLEIC ACID - Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for | 2009-12-10 |
20090305294 | METHOD OF ISOLATING NUCLEIC ACIDS FROM STOOL SAMPLES - The present invention relates to a method of isolating a nucleic acid molecule form a biological sample. More particularly, the present invention relates to a method of isolating ribonucleic acid molecule from a biological sample. The method of the present invention is useful in a range of applications including, but not limited to, diagnostic applications and research and development applications, to the extent that the isolation of nucleic acid molecules, and in particular ribonucleic acid molecules, is required. Most particularly, the method of the present invention provides for the isolation of ribonucleic acid molecules which are suitable for analysis by reverse transcriptase-PCR. | 2009-12-10 |
20090305295 | IDENTIFICATION OF A GENE EXPRESSION PROFILE THAT DIFFERENTIATES ISCHEMIC AND NONISCHEMIC CARDIOMYOPATHY - A method of preparing a gene expression prediction profile for distinguishing ischemic and nonischemic cardiomyopathy comprises the steps of obtaining clinical specimens from patients suffering from ischemic or nonischemic cardiomyopathy, isolating nucleic acid sequences from at least a plurality of said specimens, obtaining a gene expression level corresponding to each individual of said nucleic acid sequence by a gene expression profiling method, identifying genes having differences in gene expression by comparing the gene expression level of an ischemic specimen with the gene expression level of a nonischemic specimen, and identifying a gene expression prediction profile comprises genes identified as having differences in gene expression so that said prediction profile distinguishes ischemic and nonischemic cardiomyopathy. | 2009-12-10 |
20090305296 | TEST KIT FOR DETECTING PERIODONTAL DISEASE - A test kit is disclosed for diagnosing periodontal disease in a patient by analysing a sample from the oral cavity of the patient. The test kit includes at least a first detection assay for detection of a first substance originating from bacteria and at least a second detection assay for detection of a second substance originating from the immune or inflammatory system of the patient. | 2009-12-10 |
20090305297 | Tyrosine phosphorylation sites - The invention discloses 397 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above. | 2009-12-10 |
20090305298 | Binder for C-Reactive Protein - A polypeptide dimer is provided wherein both protomers have a sequence according to SEQ ID NO: 1 and at least one phosphocholine derivative is attached to the polypeptide. The polypeptide shows a specific binding for C-reactive protein (CRP). The utilization of the polypeptide in assays for determining the concentration of CRP is described. The purification of CRP, and compositions comprising the CRP also are provided. | 2009-12-10 |
20090305299 | Method for Determination of Prognosis of Prostate Cancer, and Diagnostic Agent for Use in the Method - A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-κB-p65/RelA has the 254th amino acid threonine which is phosphorylated is significantly higher in the prostate cancer cells in the cases where the bone metastasis was observed than in the cases where bone metastasis was not observed. Thus, the method for determining probability that prostate cancer will metastasize comprises measuring human NF-κB-p65/RelA in which 254th amino acid threonine is phosphorylated, which human NF-κB-p65/RelA is contained in a prostate tissue separated from human. | 2009-12-10 |
20090305300 | METHODS AND KITS TO DIAGNOSE GROWTH HORMONE DEFICIENCY - A method of assessing growth hormone deficiency in a human or animal subject, the method comprising administering orally to the subject EP 1572 (Formula I) or EP 1573 (Formula II), obtaining a post-administration sample from the subject, determining the level of growth hormone in the sample and assessing whether the level of growth hormone in the sample is indicative of growth hormone deficiency in the subject. Preferably, the GH level in the sample is measured by immunoassay. Also disclosed is a kit of parts constituting a diagnostic kit comprising: (a) EP 1572 or EP 1573 formulated for oral administration; and (b) means for determining the level of growth hormone in a sample. | 2009-12-10 |
20090305301 | DETECTION OF VENOUS THROMBOEMBOLIC DISEASES BY MEASUREMENT OF D-DIMERS AND SOLUBLE FIBRIN LEVELS - A method and a test for detecting coagulation activation, in particular when it is responsible for thromboembolic venous diseases; employs assaying D-dimers and assaying the soluble fibrin produced during a fibrinolysis process activated in a blood sample. The method of the invention pertains to comparing the level of D-dimers corresponding to degradation of soluble fibrin and the level of D-dimers of the sample with normal threshold values. The test of the invention may also be used to determine whether anti-coagulation is sufficient in a patient. | 2009-12-10 |
20090305302 | MYCOBACTERIAL CULTURE SCREENING TEST FOR MYCOBACTERIUM AVIUM COMPLEX BACTERIA - A method of antigen-capture assays that uses the detection of antigens secreted into liquid culture is provided. Also provided are antibodies to | 2009-12-10 |
20090305303 | IMMUNOCHROMATOGRAPHY DEVICE FOR THE DIAGNOSIS OF DISEASES IN A SAMPLE - An immunochromatography device for determining the presence of a binding analyte in a biological sample of a subject, includes the steps of a sample application site for receiving the biological sample; at least one conjugate pad allowing the binding analyte present in the biological sample to bind to a labeled agent; and at least one test pad comprising assay areas, wherein the sample application site is adapted to direct at least part of said biological sample of a subject through the at least one conjugate pad into at least three assay areas of the at least one test pad and at least one of the at least one test pad comprises two assay areas. | 2009-12-10 |
20090305304 | High Resolution Label Free Analysis of Cellular Properties - The invention provides methods of detecting a change in cell growth patterns. | 2009-12-10 |
20090305305 | Method and probes for the detection of a tumor-specific fusion protein - The invention relates to the detection of fusion proteins. Described are a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least the first and second probes wherein the reactive group allows modulation of juxtaposing the probes such that there is an increased likelihood of energy transfer between the dyes. A method is provided which permits detecting the presence of a fusion protein in a cell at the single cell level. | 2009-12-10 |
20090305306 | Lectin Complement Pathway Assays and Related Compositions and Methods - This invention is related, in part, to assays for analyzing the lectin complement pathway (LCP) as well as to compositions and methods related thereto. | 2009-12-10 |
20090305307 | Methods for detecting targets - The present invention provides method and compositions for detecting target molecules present on cells and tissues. In particular, the methods involve adding primary antibodies such as scFv-targeted lactamase that are directed against a target of interest (e.g., cancer markers) to a tissue sample, followed by adding a lactam-containing compound and finally a lactamase reporter system. In some preferred embodiments, the lactamase reporters are fluorescent reporters that bind to the test tissue. In some particularly preferred embodiments, the test tissue contains at least once cancer cell and/or at least one cancer-associated marker. | 2009-12-10 |
20090305308 | METHOD FOR IDENTIFYING CELL-SPECIFIC PROTEIN COMBINATION PATTERNS - The present invention discloses a method for identifying cell-specific protein combination patterns of cell surfaces of circulating cells of the immune system of a human or animal for the identification of different stages of organ-specific chronic inflammatory diseases or tumour diseases comprising the following steps: a) providing a sample of circulating cells of the immune system of a human or animal showing an organ-specific chronic inflammatory disease or tumour disease and providing a sample of circulating cells of the same cell type of the immune system of a healthy human or animal; b) determining cell-specific protein combination patterns of the cell surfaces of said healthy and pathologically modified cells; c) comparing the resulting protein combination patterns of the cell surfaces of said healthy and pathologically modified cells and subtracting the coincident parts of the protein combination patterns of said healthy and pathologically modified cells, thereby determining a cell-specific protein combination patterns of the cell surfaces of said pathologically modified cells resulting therefrom; and d) identifying and characterizing the resulting cell-specific protein combination pattern of the cell surfaces of said pathologically modified circulating cells of the immune system in terms of molecules and its spatial arrangement within the cell as disease specific. The invention moreover relates to compositions and kits comprising antibodies and/or ligands which can be employed for the performance of the method. | 2009-12-10 |
20090305309 | Methods and Compositions for Detecting Neoplastic Cells - Methods and compositions for identifying neoplastic cells in a biological sample are provided. | 2009-12-10 |
20090305310 | Methods for Determining Notch Signaling and Uses Thereof - The invention relates, in part, to methods of determining Notch signaling in cells, tissues and/or subjects. The invention additionally relates, in part, to diagnostic assays for cell differentiation-associated diseases or conditions and for screening tools in research and clinical applications. | 2009-12-10 |
20090305311 | C4D/C4B STANDARD FOR QUANTITATIVE FLOW CYTOMETRY OF HUMORAL TRANSPLANT REJECTION - The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient. | 2009-12-10 |
20090305312 | In Vitro Diagnostic Method and Kit for an Aspergillus Infection - The present invention relates to a method for the in vitro diagnosis of an | 2009-12-10 |
20090305313 | Diagnosis of candidiasis and candidemia or invasive candida infection - The use of an antibody to a | 2009-12-10 |
20090305314 | Upregulation of Adamts4 Protease Activity for the Treatment of Alzheimer's Disease - The invention provides methods of identifying compounds suitable for treating Alzheimer's disease and related conditions by means of modulation of ADAMTS4. | 2009-12-10 |
20090305315 | HUBBED DUAL CANNULA DEVICE FOR CLOSED CONTAINER SAMPLING SYSTEMS - The present invention provides a hubbed dual cannula device for extracting a fluid sample from a closed container. The device comprises a housing hub, two substantially parallel needles, a venting valve and a hydrophobic membrane, and may be used effectively to extract a fluid sample from a sealed container, such as a vacuum tube, without damaging the cellular components or activating platelets in the fluid sample. Also provided are methods for using the disclosed device to extract a fluid sample from a closed container and kits for measuring platelet aggregation using such a device. | 2009-12-10 |
20090305316 | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase - The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the | 2009-12-10 |
20090305317 | USER INTERFACE FOR TESTING DEVICE - A testing system for testing an analyte in a fluid sample includes a user interface including a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. The testing system further includes an automarking feature adapted to identify a testing result of a control solution, the testing of the control solution being distinguishable from the testing of the fluid sample. The testing result of the control solution is not included in the information relating to the measurements of health data that is displayed to a user via the user interface. | 2009-12-10 |