51st week of 2011 patent applcation highlights part 48 |
Patent application number | Title | Published |
20110312700 | MICROFLUIDIC DEVICE WITH PWM CONTROLLED PCR HEATER - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a microsystems technology (MST) layer having a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having at least one heater for thermally cycling the nucleic acid sequences through a denaturing phase, an annealing phase and a primer extension phase, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry configured to energize the at least one heater with a pulse width modulated (PWM) signal during the thermal cycling. | 2011-12-22 |
20110312701 | LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES WITH CALIBRATED PHOTODETECTION OF PROBES IN HYBRIDIZATION ARRAY - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, detection photodiodes for exposure to the photons emitted by the ECL luminophores, and, at least one calibration photodiode for exposure to ambient light, wherein during use, a difference between the output from any of the detection photodiode and the output from the calibration photodiode is compared to a predetermined threshold difference such that output differences greater than the predetermined threshold indicate the target is present. | 2011-12-22 |
20110312702 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, a plurality of reagent reservoirs, a lysis section downstream of the dialysis section for lysing the target cells to release the genetic material therein, the lysis section being in fluid communication with one of the reagent reservoirs containing a lysis reagent for lysing the target cells in the lysis section, and, a nucleic acid amplification section downstream of the lysis section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the lysis section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312703 | MICROFLUIDIC DEVICE FOR RAPID PCR AMPLIFICATION - A microfluidic device having a supporting substrate, a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid sequences, the PCR section having a PCR chamber, and, a heater element for heating the nucleic acid sequences within the PCR chamber, wherein during use, the PCR section generates sufficient amplicon for hybridization with an array of probes in less than 10 minutes. | 2011-12-22 |
20110312704 | MICROFLUIDIC DEVICE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample, polymerase, dNTP's and buffer solution to amplify the nucleic acid sequences, the PCR microchannel defining a flow-path for the sample such that flow of the sample along the PCR microchannel is driven by capillary action, wherein, the PCR mixture has a volume less than 400 nanoliters. | 2011-12-22 |
20110312705 | TEST MODULE FOR PCR AMPLIFICATION USING LOW PCR MIXTURE VOLUME - A test module for amplifying nucleic acid sequences in a sample fluid, the test module having an outer casing with receptacle for receiving the sample fluid, a polymerase chain reaction (PCR) section with a PCR microchannel for thermally cycling a PCR mixture of the sample fluid, polymerase, dNTP's, primers, and buffer solution to amplify the nucleic acid sequences, wherein, the PCR mixture has a volume less than 400 nanoliters. | 2011-12-22 |
20110312706 | LOC DEVICE WITH HYBRIDIZATION CHAMBERS CONTAINING PROBES FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES IN A FLUID AND CALIBRATION CHAMBER CONTAINING PROBES SEALED FROM THE FLUID - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having hybridization chambers containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one calibration chamber containing probes sealed from contact with the fluid, and, electrodes for receiving an electrical pulse to excite the ECL luminophores. | 2011-12-22 |
20110312707 | GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample, and, a polymerase chain reaction (PCR) section for thermal cycling the sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences. | 2011-12-22 |
20110312708 | GENETIC ANALYSIS LOC FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the sample to form an amplification mix, and, a nucleic acid amplification section for controlling the temperature of the amplification mix during isothermal amplification of the target nucleic acid sequences. | 2011-12-22 |
20110312709 | LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENT PROBES AND CALIBRATION PROBES WITH DETECTION PHOTOSENSORS AND CALIBRATION PHOTOSENSORS - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, at least one calibration source configured to generate a calibration emission, electrodes for receiving an electrical pulse to excite the ECL luminophores, at least one detection photodiode for sensing photon emissions from the ECL luminophores and generating a detection output, at least one calibration photodiode for sensing the calibration emission and generating a calibration output, and, CMOS circuitry having a differential circuit for subtracting the calibration output from the detection output. | 2011-12-22 |
20110312710 | LOC DEVICE FOR PATHOGEN DETECTION, GENETIC ANALYSIS AND PROTEOMIC ANALYSIS WITH DIALYSIS, CHEMICAL LYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte stream containing cells and sample constituents smaller than a first size threshold, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream containing cells and sample constituents smaller than a second size threshold, a leukocyte lysis section downstream of the leukocyte dialysis section for lysing the leukocytes with a lysis reagent to release genetic material and proteins therein, a leukocyte incubation section downstream of the leukocyte lysis section for enzymatic reaction of the genetic material with enzymes, a leukocyte nucleic acid amplification section downstream of the leukocyte incubation section for amplifying nucleic acid sequences, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material and proteins therein, a pathogen incubation section downstream of the pathogen lysis section for enzymatic reaction of the genetic material with enzymes, a pathogen nucleic acid amplification section downstream of the pathogen incubation section for amplifying nucleic acid sequences, an erythrocyte lysis section downstream of the pathogen dialysis section for lysing the erythrocytes with a lysis reagent to release proteins therein, wherein, the leukocyte dialysis section, the pathogen dialysis section, the leukocyte lysis section, the pathogen lysis section, the erythrocyte lysis section, the leukocyte incubation section, the pathogen incubation section, the leukocyte nucleic acid amplification section and the pathogen nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312711 | MICROFLUIDIC DEVICE WITH CONTROLLABLE SHUNTS PERIPHERAL TO INTEGRATED PHOTODIODES - A microfluidic device having a probe for hybridization with a target nucleic acid sequence, a photodiode for detecting fluorescence emissions generated by hybridization of the probe in response to an excitation light, and, a shunt transistor between the photodiode anode and a voltage source, the shunt transistor being configured to remove carriers generated by absorption of photons of the excitation light in the photodiode, wherein, a peripheral edge of the photodiode and a peripheral edge of the shunt transistor contiguously abut each other. | 2011-12-22 |
20110312712 | GENETIC ANALYSIS LOC FOR PCR AMPLIFICATION OF NUCLEIC ACIDS FROM WHOLE BLOOD - A lab-on-a-chip (LOC) device for genetic analysis of a whole blood sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the whole blood sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase for addition to the whole blood sample, and, a polymerase chain reaction (PCR) section for thermal cycling the whole blood sample, buffer, dNTPs, primers, and polymerase to amplify the target nucleic acid sequences. | 2011-12-22 |
20110312713 | MICROFLUIDIC TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBERS FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET NUCLEIC ACID SEQUENCES IN A FLUID - A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing configured for hand-held portability, the outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, a hybridization chamber mounted in the casing, the hybridization chamber containing electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the hybridization chamber has a volume less than 900,000 cubic microns. | 2011-12-22 |
20110312714 | GENETIC ANALYSIS LOC FOR AMPLIFICATION OF NUCLEIC ACIDS USING DNA POLYMERASES OF THERMOPHILES - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer, dNTPs, primers, and polymerase derived from a thermophilic bacterium for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for controlling the temperature of the amplification mixture during amplification of the target nucleic acid sequences. | 2011-12-22 |
20110312715 | MICROFLUIDIC TEST MODULE WITH LOW MASS ELECTROCHEMILUMINESCENT PROBE SPOTS - A microfluidic test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probe spots in contact with each of the electrode pairs respectively, the ECL probe spots containing ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the mass of the ECL probes in each of the probe spots is less than 270 picograms. | 2011-12-22 |
20110312716 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING AN ISOTHERMAL REACTION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing buffer solution, dNTPs, primers, and polymerase for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences. | 2011-12-22 |
20110312717 | LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, INCUBATION AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for detecting pathogens in a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a pathogen dialysis section for separating pathogens from constituents smaller than a predetermined threshold, a pathogen lysis section downstream of the pathogen dialysis section for lysing the pathogens with a lysis reagent to release genetic material therein, an incubation section downstream of the pathogen dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the pathogen dialysis section, the pathogen lysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312718 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING RECOMBINASE POLYMERASE AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, recombinase, DNA polymerase and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during recombinase polymerase amplification (RPA) of the target nucleic acid sequences. | 2011-12-22 |
20110312719 | TEST MODULE WITH INTEGRAL PHOTOSENSOR FOR ELECTROCHEMILUMINESCENT DETECTION OF HYBRIDIZATION - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having a receptacle for receiving the fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, and, a detection photosensor for exposure to the photons emitted by the ECL luminophores. | 2011-12-22 |
20110312720 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a dialysis section for separating smaller constituents from larger constituents, the smaller constituents being smaller than a predetermined size threshold, and the larger constituents being larger than the predetermined size threshold, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the dialysis section and the nucleic acid amplification section are both supported on the supporting substrate. | 2011-12-22 |
20110312721 | LOC DEVICE FOR GENETIC ANALYSIS WITH DIALYSIS, INCUBATION, AND NUCLEIC ACID AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample, a supporting substrate, a plurality of reagent reservoirs, a dialysis section for separating cells larger than a predetermined threshold in the sample from smaller constituents, whereby the cells larger than a predetermined threshold include target cells containing genetic material for analysis, an incubation section downstream of the dialysis section, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences from the genetic material, wherein, the dialysis section, the incubation section and the nucleic acid amplification section are all supported on the supporting substrate. | 2011-12-22 |
20110312722 | PORTABLE TEST MODULE FOR EXCITATION OF ELECTROCHEMILUMINESCENT PROBES - A portable test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing configured for hand-held portability, the outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes. | 2011-12-22 |
20110312723 | GENETIC ANALYSIS LOC FOR NUCLEIC ACID AMPLIFICATION USING NUCLEIC ACID SEQUENCE BASED AMPLIFICATION - A lab-on-a-chip (LOC) device for genetic analysis of a sample containing target nucleic acid sequences, the LOC device having a sample inlet for receiving the sample, a plurality of reagent reservoirs containing dNTPs, primers, reverse transcriptase, RNA polymerase, and buffer solution for addition to the sample to form an amplification mixture, and, a nucleic acid amplification section for maintaining the amplification mixture at a predetermined temperature during isothermal amplification of the target nucleic acid sequences. | 2011-12-22 |
20110312724 | LOC DEVICE FOR PATHOGEN DETECTION AND GENETIC ANALYSIS WITH INCUBATION, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING - A lab-on-a-chip (LOC) device for pathogen detection and genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, an incubation section downstream of the inlet, the incubation section being in fluid communication with one of the reagent reservoirs containing enzymes for enzymatic reaction with the genetic material, and, a nucleic acid amplification section downstream of the incubation section for amplifying nucleic acid sequences in the genetic material, and, a dialysis section downstream of the nucleic acid amplification section for prehybridization filtration of amplicon produced by the nucleic acid amplification section, the dialysis section being configured to remove cell debris from the amplicon, wherein, the incubation section, the nucleic acid amplification section and the dialysis section are all supported on the supporting substrate. | 2011-12-22 |
20110312725 | USB-INTERFACEABLE PORTABLE TEST MODULE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing having a receptacle for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, electrodes for receiving an electrical pulse to excite the ECL luminophores, a detection photosensor for exposure to the photons emitted by the ECL luminophores, control circuitry providing the electrical pulse to the electrodes, and, a universal serial bus (USB) connection such that the outer casing is configured as a USB drive for transmitting data regarding detection of the targets in the fluid to an external device, wherein during use, the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes. | 2011-12-22 |
20110312726 | MICROFLUIDIC DEVICE WITH CONTROLLABLE SHUNTS INSIDE INTEGRATED PHOTODIODES - A microfluidic device having a probe for hybridization with a target nucleic acid sequence to form a probe-target hybrid, a photodiode having an active area for detecting fluorescence emissions generated by the probe-target hybrid in response to an excitation light, and, a shunt transistor between the photodiode anode and a voltage source, the shunt transistor being configured to remove carriers generated by absorption of photons of the excitation light in the photodiode, wherein, the shunt transistor is encompassed by the active area. | 2011-12-22 |
20110312727 | LOC DEVICE WITH PARALLEL NUCLEIC ACID AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, and, a second nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate. | 2011-12-22 |
20110312728 | MICROFLUIDIC DEVICE WITH NON-IMAGING OPTICS - A microfluidic device having a supporting substrate, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form probe-target hybrids, the probe-target hybrids being configured to generate a fluorescence signal in response to an excitation light, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the active area is less than 249 microns from the probe-target hybrids. | 2011-12-22 |
20110312729 | TEST MODULE USING TRANSITION METAL-LIGAND COMPLEX, ELECTROCHEMILUMINESCENT LUMINOPHORES - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, such that the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes, wherein, the ECL luminophore has a transition metal-ligand complex. | 2011-12-22 |
20110312730 | LOC DEVICE WITH PARALLEL DNA AND RNA AMPLIFICATION FUNCTIONALITY - A lab-on-a-chip (LOC) device for genetic analysis of a biological sample, the LOC device having an inlet for receiving the sample containing genetic material including DNA and RNA, a supporting substrate, a plurality of reagent reservoirs, a first nucleic acid amplification section for amplifying at least some of the genetic material, and, a second nucleic acid amplification section for amplifying at least some the genetic material in parallel with the first nucleic acid amplification section, wherein, the first nucleic acid amplification section and the second nucleic acid amplification section are both supported on the supporting substrate. | 2011-12-22 |
20110312731 | MICROFLUIDIC DEVICE WITH LARGE ANGLE OF COLLECTION OF EMISSION LIGHT - A microfluidic device having a supporting substrate, a hybridization chamber containing probes having a nucleic acid sequence for hybridization with a target nucleic acid sequence to form probe-target hybrids and generate a fluorescence signal in response to an excitation light, and, a photodiode with an active area and an optical axis extending normal to the active area and through the hybridization chamber, wherein, the hybridization chamber has a floor surface positioned parallel to the active area of the photodiode, the floor surface having a centroid and the active area being encompassed within a cone having the centroid at its vertex, and a vertex angle less than 173°. | 2011-12-22 |
20110312732 | TEST MODULE USING LANTHANIDE METAL-LIGAND COMPLEX, ELECTROCHEMILUMINESCENT LUMINOPHORES - A test module for excitation of electrochemiluminescent probes configured to detect target nucleic acid sequences, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, electrochemiluminescent (ECL) probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, such that the ECL probes that have detected one of the target nucleic acid sequences reconfigure such that the functional moiety does not quench the photon emission from the ECL luminophore when excited by the electrodes, wherein, the ECL luminophore has a lanthanide metal-ligand complex. | 2011-12-22 |
20110312733 | LOC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A lab-on-a-chip (LOC) device for amplifying nucleic acid sequences, the LOC device having an inlet for receiving a sample containing genetic material, a supporting substrate, a plurality of reagent reservoirs, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material, wherein, the nucleic acid amplification section is supported on the supporting substrate. | 2011-12-22 |
20110312734 | TEST MODULE WITH SUSPENDED ELECTROCHEMILUMINESCENT PROBES - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing having an inlet for receiving the fluid containing the target nucleic acid sequences, electrode pairs for receiving an electrical pulse, electrochemiluminescent (ECL) probes adjacent each of the electrode pairs respectively, each of the ECL probes having an ECL luminophore for emitting photons when in an excited state and a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, such that the electrical pulse to the electrode pair excites the ECL luminophores, wherein, the ECL probes are not anchored to a surface and form a suspension in the fluid containing the target nucleic acid sequences during detection. | 2011-12-22 |
20110312735 | MICROFLUIDIC DEVICE WITH NUCLEIC ACID AMPLIFICATION SECTION - A microfluidic device for amplifying nucleic acid sequences, the microfluidic device having an inlet for receiving a sample containing genetic material, a plurality of reagent reservoirs containing reagents for addition to the sample, and, a nucleic acid amplification section for amplifying nucleic acid sequences in the genetic material. | 2011-12-22 |
20110312736 | MICROFLUIDIC DEVICE WITH FLOW RATE SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least one of the functional sections, a flow rate sensor with a conductive element positioned in proximity of the fluid flowing along the flow-path, CMOS circuitry configured for measuring the temperature of the conductive element, wherein, the CMOS circuitry is configured to provide a predetermined current through the conductive element and measure the electrical resistance of the conductive element such that a flow speed is derived from the current, the temperature sensor output and the electrical resistance, and a flow rate is derived using the flow speed and the flow-path cross section transverse to the flow direction at the conductive element. | 2011-12-22 |
20110312737 | SINGLE-USE TEST MODULE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for detecting target nucleic acid sequences in a fluid, the test module having an outer casing with an inlet for receiving a fluid containing the target nucleic acid sequences, an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, electrodes positioned for receiving an electrical pulse, the probe-target hybrids being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes. | 2011-12-22 |
20110312738 | MICROFLUIDIC DEVICE WITH LIQUID SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least some of the functional sections, circuitry for operative control of the functional sections, and, a liquid sensor with electrodes positioned for contact with the fluid flowing along the flow-path, wherein, the circuitry is configured to provide a voltage across the electrodes such that current above a predetermined threshold is indicative of liquid at the electrodes. | 2011-12-22 |
20110312739 | SINGLE-USE TEST MODULE FOR PCR AMPLIFICATION OF TARGETS AND ELECTROCHEMILUMINESCENT DETECTION OF TARGETS - A test module for amplifying and detecting target nucleic acid sequences in a fluid, the test module having an outer casing with a receptacle for receiving a fluid containing the target nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences, an array of electrochemiluminescent (ECL) probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, electrodes positioned for receiving an electrical pulse, the probe-target hybrids being configured to emit a photon of light when excited by current between the electrodes, and, a photosensor for detecting the light emitted by the probes, wherein during use, addition of the fluid to the probes prevents subsequent addition of other fluid to the probes. | 2011-12-22 |
20110312740 | MICROFLUIDIC DEVICE WITH CAPILLARY MENISCUS MARCHING VELOCITY SENSOR - A microfluidic device for processing a fluid, the microfluidic device having an inlet for receiving the fluid, functional sections for processing the fluid, a flow-path extending from the inlet into at least some of the functional sections, circuitry for operative control of the functional sections, and, a capillary meniscus marching velocity sensor having a plurality of liquid sensors spaced along the flow-path, each of the liquid sensors having electrodes positioned for contact with the fluid flowing along the flow-path, wherein, the circuitry is configured to provide a voltage across the electrodes such that current above a predetermined threshold is indicative of liquid at the electrodes and used to derive a velocity of the liquid flow front. | 2011-12-22 |
20110312741 | MICROFLUIDIC DEVICE FOR ANALYSIS OF MITOCHONDRIAL DNA - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids. | 2011-12-22 |
20110312742 | SINGLE-USE MICROFLUIDIC DEVICE - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, a probe with a nucleic acid sequence for hybridization with the target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, a photosensor for sensing the fluorescence signal, wherein during use, addition of the biological sample to the inlet prevents fluid communication between a fluid subsequently added to the inlet and the probe. | 2011-12-22 |
20110312743 | LOC DEVICE FOR DETECTION OF TARGET NUCLEIC ACID SEQUENCES USING ELECTRODES CONFIGURED FOR ELECTROCHEMILUMINESCENCE OF LUMINOPHORES WITHOUT A COREACTANT - A lab-on-a-chip (LOC) device for detecting target nucleic acid sequences in a fluid, the LOC device having electrochemiluminescent (ECL) probes for detecting the target nucleic acid sequences, each of the probes having an ECL luminophore for emitting photons when in an excited state, a functional moiety for quenching photon emission from the ECL luminophore by resonant energy transfer, and, electrodes for receiving an electrical pulse to excite the ECL luminophores, wherein, the electrodes are arranged into pairs, each having an anode and a cathode, the anode and the cathode being separated by a dielectric gap between 0.4 microns and 2 microns wide. | 2011-12-22 |
20110312744 | MICROFLUIDIC DEVICE FOR AMPLIFYING MITOCHONDRIAL DNA IN A BIOLOGICAL SAMPLE - A microfluidic device for amplifying mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with an outer cellular membrane containing mitochondria and a nucleus, the mitochondria having a mitochondrial membrane containing mitochondrial DNA and the nuclei having a nuclear membrane containing nuclear DNA, a lysis section for lysing the outer cellular membrane and the mitochondrial membrane while the nuclear membrane remains intact, and, a nucleic acid amplification section configured for amplifying target nucleic acid sequences in the mitochondrial DNA. | 2011-12-22 |
20110312745 | MICROFLUIDIC TEST MODULE WITH PHOTOSENSOR - A test module for analyzing a sample fluid containing target molecules, the test module having an outer casing with a receptacle for receiving the sample fluid, probes for reaction with the target molecules to form probe-target complexes, the probe-target complexes being configured to emit photons when excited, and, a photosensor for detecting photons emitted by the probe-target complexes. | 2011-12-22 |
20110312746 | MICROFLUIDIC DEVICE WITH CHEMICAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the inlet for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 2011-12-22 |
20110312747 | MICROFLUIDIC DEVICE FOR BIOCHEMICAL PROCESSING AND ANALYSIS - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus. | 2011-12-22 |
20110312748 | LOC WITH INTEGRAL PHOTOSENSOR FOR DETECTION OF HYBRIDIZATION ASSAY RESULTS - A microfluidic device having a supporting substrate, an array of probes for hybridization with a target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, a photosensor positioned adjacent the array of probes, wherein, the photosensor is configured for sensing which probes within the array of probes generated the fluorescence signal. | 2011-12-22 |
20110312749 | MICROFLUIDIC DEVICE WITH THERMAL LYSIS SECTION - A microfluidic device for lysing cells in a fluid, the microfluidic device having an inlet channel for receiving a fluid containing cells, a lysis section in fluid communication with the inlet channel for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section such that the cells lyse, wherein, the inlet channel is configured for filling the lysis section by capillary action. | 2011-12-22 |
20110312750 | MICROFLUIDIC DEVICE WITH TOTAL REAGENT STORAGE - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a plurality of reagent reservoirs containing all reagents necessary for the biochemical processing, wherein, each of the reagent reservoirs have an outlet with a surface tension valve for retaining the reagent in the reservoir with a reagent meniscus until contact with the biochemical liquid removes the reagent meniscus. | 2011-12-22 |
20110312751 | MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA FLUORESCENCE MODULATED BY HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, fluorescence resonance energy transfer (FRET) probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 2011-12-22 |
20110312752 | MICROFLUIDIC DEVICE WITH LOW-VOLUME REAGENT RESERVOIR - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent necessary for the biochemical processing, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns. | 2011-12-22 |
20110312753 | LOC WITH INTEGRAL LED DRIVER FOR EXCITATION LED - A microfluidic device having a supporting substrate, a probe with a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid and generate a fluorescence signal in response to an excitation light, and, CMOS circuitry on the supporting substrate for operative control of the excitation light. | 2011-12-22 |
20110312754 | MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA ELECTROCHEMILUMINESCENCE MODULATED HYBRIDIZATION - A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, electrochemiluminescent (ECL) resonance energy transfer probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids. | 2011-12-22 |
20110312755 | TEST MODULE WITH CHEMICAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having an outlet valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, wherein, the outlet valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 2011-12-22 |
20110312756 | MICROFLUIDIC DEVICE WITH LOW REAGENT VOLUMES - A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving biochemical liquid, and, a reagent reservoir containing a reagent necessary for the biochemical processing, wherein, the reagent reservoir contains less than 1,000,000,000 cubic microns of reagent. | 2011-12-22 |
20110312757 | REAGENT MICROVIAL WITH DIGITAL MEMORY - A reagent microvial for a reagent dispensing apparatus, the microvial having a container for holding a volume of reagent, a digital memory for data relating to the reagent, a droplet generator for ejecting droplets of the reagent from the container, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to receive drive pulses for the droplet generator and provide the data to the control processor. | 2011-12-22 |
20110312758 | TEST MODULE WITH THERMAL LYSIS SECTION - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a sample that is a fluid containing cells, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, and, a lysis heater for heating the fluid in the lysis section to lyse cells, wherein, the test module is configured for drawing the fluid from the receptacle to the lysis section by capillary action. | 2011-12-22 |
20110312759 | GENETIC ANALYSIS LOC WITH REAGENT RESERVOIR - A LOC device for performing a genetic diagnostic assay, the LOC device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, a flow-path extending from the inlet to the probes, and, a reagent reservoir containing a reagent for addition to the sample in the flow-path upstream of the probes. | 2011-12-22 |
20110312760 | REAGENT MICROVIAL WITH AUTHENTICATION INTEGRATED CIRCUIT - A reagent microvial for a reagent dispensing apparatus, the microvial having a container for holding a volume of reagent, an integrated circuit with digital memory for data relating to an identity of the microvial, and, electrical contacts for connection to a control processor in the reagent dispensing apparatus to provide the data to the control processor for comparison with a list of authentic microvial identities. | 2011-12-22 |
20110312761 | TEST MODULE FOR CHEMICALLY AND THERMALLY LYSING CELLS - A test module for lysing cells in a fluid, the test module having an outer casing with receptacle for receiving a fluid containing cells, a lysis reagent reservoir containing a lysis reagent and having a valve, and, a lysis section in fluid communication with the receptacle for holding the fluid during lysis of the cells, the lysis section having a lysis heater for heating the fluid in the lysis section, wherein, the valve is upstream of the lysis section and configured to open as the fluid flows into the lysis section thereby adding the lysis reagent to the fluid. | 2011-12-22 |
20110312762 | LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET) PROBES - A lab-on-a-chip (LOC) device having a supporting substrate, a microsystems technologies (MST) layer with a hybridization section that has an array of fluorescence resonance energy transfer (FRET) probes for hybridization with target nucleic acid sequences in a fluid, and, a photosensor for detecting hybridization of probes within the array of probes. | 2011-12-22 |
20110312763 | GENETIC ANALYSIS LOC WITH IN-LOC STORAGE OF ALL REQUIRED REAGENTS - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, probes for hybridization with the target nucleic acid sequence to form probe-target hybrids, and, a plurality of reagent reservoirs containing all reagents necessary for performing the diagnostic assay. | 2011-12-22 |
20110312764 | MICROFLUIDIC DEVICE WITH INCUBATOR - A microfluidic device having a supporting substrate, an inlet for receiving a fluid, a microsystems technology (MST) layer for processing the fluid, the MST layer incorporating an incubation section, the incubation section having at least one heater for maintaining the fluid at a predetermined incubation temperature, and, CMOS circuitry between the MST layer and the supporting substrate, the CMOS circuitry being connected to the at least one heater for operative control of the at least one heater. | 2011-12-22 |
20110312765 | GENETIC ANALYSIS LOC WITH LOW OLIGONUCLEOTIDE PROBE MASS AND LOW REAGENT VOLUME - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a biological sample containing target nucleic acid sequences, a hybridization section comprising an array of chambers with probes for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a reagent reservoir containing a reagent necessary for processing the biological sample prior to hybridization, wherein, the hybridization section contains less than 270 picograms of each probe per chamber and the reagent reservoir containing less than 1000,000,000 cubic microns of the reagent. | 2011-12-22 |
20110312766 | MICROFLUIDIC DEVICE WITH FEEDBACK CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater, and, at least one sensor, wherein, the at least one sensor is configured to provide output for feedback control of the at least one heater. | 2011-12-22 |
20110312767 | MICROFLUIDIC DEVICE WITH INCUBATION SECTION HAVING TEMPERATURE FEEDBACK - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section for maintaining the fluid sample at an incubation temperature, the incubation section having at least one heater and at least one temperature sensor, wherein, the at least one temperature sensor is configured to provide output for feedback control of the at least one heater. | 2011-12-22 |
20110312768 | LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PCR AMPLIFICATION USING PRIMERS COVALENTLY ATTACHED TO STEM-AND-LOOP PROBES - A LOC device having a supporting substrate, primer-linked, stem-and-loop probes, each with a nucleic acid sequence that matches one of a plurality of target nucleic acid sequences, and a primer for elongating against the target nucleic acid sequence to form a complementary sequence such that during use the nucleic acid sequence matching the target nucleic acid sequence anneals to the complementary sequence to change a fluorescence emission from the probe in response to an excitation light, a polymerase chain reaction (PCR) section for amplifying the target nucleic acid sequences in the fluid prior to hybridization with the FRET probes, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having operative control of the excitation light. | 2011-12-22 |
20110312769 | TEST MODULE WITH LOW-VOLUME REAGENT RESERVOIR - A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical liquid, and, a reagent reservoir containing a reagent for addition to the biochemical liquid for use in chemical analysis of the biochemical liquid, wherein, the reagent reservoir has a volume less than 1000,000,000 cubic microns. | 2011-12-22 |
20110312770 | LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH NUCLEIC ACID AMPLIFICATION USING PRIMERS COVALENTLY ATTACHED TO LINEAR PROBES - A LOC device having a supporting substrate, a primer-linked, linear probe with a nucleic acid sequence that matches a target nucleic acid sequence, and a primer for elongating against the target nucleic acid sequence to form a complementary sequence such that during use the nucleic acid sequence matching the target nucleic acid sequence anneals to the complementary sequence to change a fluorescence emission from the probe in response to an excitation light, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having operative control of the excitation light. | 2011-12-22 |
20110312771 | MICROFLUIDIC DEVICE WITH PWM CONTROLLED INCUBATION SECTION - A microfluidic device having a sample inlet for receiving a fluid sample, an incubation section in fluid communication with the sample inlet, the incubation section having at least one heater for maintaining the fluid sample at an incubation temperature for an incubation period, and, CMOS circuitry to energize the at least one heater with a pulse width modulated (PWM) signal. | 2011-12-22 |
20110312772 | LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PCR AMPLIFICATION USING LINKER PRIMERS - A LOC device for amplifying nucleic acid sequences and detecting target nucleic acid sequences, the LOC device having a supporting substrate, restriction enzymes for digesting double stranded nucleic acid sequences at known restriction sites, linker primers for ligation to the restricted ends of the double stranded nucleic acid sequences, heaters for thermally cycling the nucleic acid sequences through a polymerase chain reaction (PCR) process, deoxyribonucleoside triphosphates (dNTPs) for extending the linker primers along the nucleic acid sequences, and, probes for hybridizing with target nucleic acid sequences. | 2011-12-22 |
20110312773 | MICROFLUIDIC DEVICE WITH FAULT-TOLERANT MULTIPLE VALVE ASSEMBLY - A microfluidic device having an inlet for receiving a liquid flowing through the microfluidic device, an outlet downstream of the inlet, and, a fault-tolerant multiple valve assembly having a plurality of flow-paths extending from the inlet to the outlet and a plurality of valves positioned along each of the flow-paths respectively. | 2011-12-22 |
20110312774 | MICROFLUIDIC DEVICE FOR DIFFUSIVE MIXING IN SMALL CROSS SECTIONAL AREA MICROCHANNEL - A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate, the MST layer being configured to combine at least two liquids to form a flow of combined liquids, the MST layer having a diffusion mixing section for diffusive mixing of the at least two liquids, the mixing section having a microchannel defining a flow-path for the combined liquids, wherein, the channel cross section transverse to the flow direction is less than 100,000 square microns. | 2011-12-22 |
20110312775 | MICROFLUIDIC DEVICE WITH DIGITAL MEMORY - A microfluidic device for analyzing a sample fluid, the microfluidic device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312776 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH POSITIVE CONTROL CHAMBERS INCORPORATING REPORTERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequence to form a probe-target hybrid, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a reporter with a fluorophore positioned for exposure to the excitation light simultaneously with the probes, wherein, the reporter always emits the fluorescence signal in response to the excitation light. | 2011-12-22 |
20110312777 | TEST MODULE WITH DIGITAL MEMORY - A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, and, digital memory for storing data and operational information to operatively control the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312778 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL CHAMBERS INCORPORATING PROBES DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, an array of probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a control probe designed to be complementary to sequences known to be absent from the biological sample. | 2011-12-22 |
20110312779 | OLIGONUCLEOTIDE SPOTTING DEVICE FOR OPERATION UNDER EXTERNAL MICROPROCESSOR CONTROL - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of ejectors, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, and, bond-pads for electrically connecting the CMOS circuitry and an external microprocessor controller for operative control of the array of ejectors. | 2011-12-22 |
20110312780 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL CHAMBERS INCORPORATING PROBES WITH NO REPORTERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, a fluorophore and a quencher configured such that the fluorophore emits a fluorescence signal in response to an excitation light and the quencher quenches the fluorescence signal when the probe is not hybridized, but fails to quench the fluorescence signal from the probe-target hybrid, and, a control probe with no fluorophore such that the control probe never emits the fluorescence signal in response to the excitation light. | 2011-12-22 |
20110312781 | LOC WITH DIGITAL MEMORY TO STORE GENETIC DATA UPDATES - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry with digital memory for storing genetic data, and configured to download genetic data updates from an external source. | 2011-12-22 |
20110312782 | OLIGONUCLEOTIDE SPOTTING DEVICE WITH DIGITAL MEMORY - An oligonucleotide spotting device for contactless spotting of probes onto a surface, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the oligonucleotide spotting device having a supporting substrate, an array of ejectors, each having an actuator for ejecting droplets of liquid containing the oligonucleotide probes, and, CMOS circuitry for providing each of the drop ejection actuators with a drive pulse for droplet ejection, wherein, the CMOS circuitry has a digital memory for storing data related to the device. | 2011-12-22 |
20110312783 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH NEGATIVE CONTROL COMPRISING EMPTY CHAMBERS - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing target nucleic acid sequences, probes that each have a nucleic acid sequence for hybridization with a respective one of the target nucleic acid sequences to form a probe-target hybrid and emit a fluorescence signal in response to an excitation light, and, photosensors corresponding to each of the probes respectively, and, a control photosensor not corresponding to any of the probes such that the control photosensor does not sense the fluorescence signal of a corresponding probe-target hybrid during correct operation of the microfluidic device. | 2011-12-22 |
20110312784 | MICROFLUIDIC DEVICE FOR DETECTING TARGETS WITH PROBES, DETECTION PHOTODIODES AND A CALIBRATION PHOTODIODE - A microfluidic device for detecting target molecules in a sample, the microfluidic device having probes for reaction with the target molecules to form probe-target complexes, the probe-target complexes being configured to emit photons when excited, photodiodes for detecting photons emitted by the probe-target complexes and a calibration photodiode for exposure to a calibration source to generate a calibration signal, wherein during use, output from the photodiodes for detecting photons emitted by the probe-target complexes is calibrated by the calibration signal. | 2011-12-22 |
20110312785 | SPOTTING DEVICE FOR SPOTTING FIXED ARRAY OF LOCS - A spotting device for contactless spotting of lab-on-a-chip (LOC) devices with oligonucleotide probes, the LOC devices being held in a fixed array on a printed circuit board (PCB) and each having an array of hybridization chambers for receiving the oligonucleotide probes, the probes having nucleic acid sequences that are complementary to target nucleic acid sequences to be identified in a biological sample, the spotting device having a monolithic supporting substrate, an array of reservoirs on one side of the supporting substrate, the reservoirs containing sufficient amount of the oligonucleotide probes suspended in a liquid to spot all the LOC devices on the PCB, and, an array of ejectors on the other side of the supporting substrate, each of the ejectors being configured for fluid communication with a corresponding one of the reservoirs respectively such that the ejectors eject droplets containing the oligonucleotide probes from the corresponding reservoir into one of the hybridization chambers. | 2011-12-22 |
20110312786 | GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING PROBE DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON - A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequences, a hybridization chamber containing probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequences to form probe-target hybrids, and, a calibration chamber containing a control probe incapable of hybridization with any sequence in the biological sample. | 2011-12-22 |
20110312787 | LOC HAVING USB DEVICE DRIVER FOR USE IN A TEST MODULE TO CONTROL USB CONNECTION - A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry on the supporting substrate, the CMOS circuitry having a universal serial bus (USB) device driver for operative control of a USB plug in the test module for communication with the external device. | 2011-12-22 |
20110312788 | GENETIC ANALYSIS LOC WITH THERMAL BOILING-INITIATED VALVE - A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, an array of probes for hybridization with target nucleic acid sequences to form probe-target hybrids, a channel for directing a flow of liquid containing the target nucleic acid sequences, the channel having an inlet, an outlet and a meniscus anchor between the inlet and the outlet such that the flow from the inlet towards the outlet stops at the meniscus anchor where the liquid forms a meniscus, and, an actuator valve with a valve heater for heating the meniscus such that the meniscus unpins from the meniscus anchor such that the liquid flow towards the outlet resumes. | 2011-12-22 |
20110312789 | LOC DEVICE WITH FLASH MEMORY - A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for processing and analyzing the sample, and, CMOS circuitry between the supporting substrate and the MST layer, the CMOS circuitry having flash memory for storing program data to operate the functional sections during processing and analysis of the sample. | 2011-12-22 |
20110312790 | MICROFLUIDIC TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER - A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing, the hybridization chamber containing probes having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, the hybridization chamber has a volume less than 900,000 cubic microns. | 2011-12-22 |
20110312791 | TEST MODULE WITH FAULT-TOLERANT MULTIPLE VALVE ASSEMBLY - A test module for genetic analysis having a casing for hand held portability, an inlet for receiving a liquid containing nucleic acid sequences, an outlet downstream of the inlet, and, a fault-tolerant multiple valve assembly having a plurality of flow-paths extending from the inlet to the outlet and a plurality of valves positioned along each of the flow-paths respectively. | 2011-12-22 |
20110312792 | TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES - A test module for analyzing a sample fluid and communicating epidemiological data to a database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the epidemiological database, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312793 | MICROFLUIDIC TEST MODULE WITH LOW MASS OF PROBES - A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing, the hybridization chamber holding a volume of fluid containing probes, the probes each having a nucleic acid sequence for hybridization with the target nucleic acid sequence to form probe-target hybrids, wherein, the mass of the probes in each of the hybridization chambers is less than 270 picograms. | 2011-12-22 |
20110312794 | TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES WITH LOCATION DATA - A test module for analyzing a sample fluid and communicating location data to an epidemiological database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the epidemiological database, and, a controller for operative control of the communication interface, wherein, the controller is configured to associate location data with epidemiological data sent to the communication interface for communication with the epidemiological database. | 2011-12-22 |
20110312795 | DIAGNOSTIC TEST MODULE WITH A LOC WITH INTEGRAL PHOTOSENSOR AND EXCITATION LED FOR DETECTION OF HYBRIDIZATION ASSAY RESULTS - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light emitting diode (LED) for illuminating the array of probes, CMOS circuitry having a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences such that the CMOS circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized, wherein, the array of probes and the CMOS circuitry are integrated on a lab-on-a-chip (LOC) device contained within the test module. | 2011-12-22 |
20110312796 | TEST MODULE THAT UPDATES MEDICAL DATABASES - A test module for analyzing a sample fluid and communicating data to a medical database, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a communication interface for communication with the medical database, and, a controller for operative control of the communication interface. | 2011-12-22 |
20110312797 | PORTABLE TEST MODULE FOR FLUORESCENCE EXCITATION OF PROBE NUCLEIC ACID SEQUENCES - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a casing configured for hand held portability, the casing having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light source for illuminating the array of probes, and a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences. | 2011-12-22 |
20110312798 | TEST MODULE WITH INBUILT LANCET - A test module for processing and analyzing a blood sample, the test module having an outer casing with a receptacle for receiving blood, functional sections for processing and analyzing the sample, and, a lancet for collecting the blood sample from a patient. | 2011-12-22 |
20110312799 | USB-INTERFACEABLE PORTABLE TEST MODULE FOR DETECTION OF HYBRIDIZED PROBES - A test module for detecting hybridization of probes with target nucleic acid sequences, the test module having a receptacle for receiving a biological sample with target nucleic acid sequences, an array of probes for hybridization with the target nucleic acid sequences, an excitation light source for illuminating the array of probes, circuitry incorporating a photosensor for sensing a fluorescence emission from any of the probes in the array that have hybridized with the target nucleic acid sequences, wherein, the circuitry is configured to use outputs from the photosensor to generate a signal indicative of the probes that have hybridized and transmit the signal to an external device. | 2011-12-22 |