52nd week of 2008 patent applcation highlights part 53 |
Patent application number | Title | Published |
20080318994 | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instruction on Dosing for Renal Impairment - The invention pertains to a method of using oxymorphone in the treatment of pain by providing a patient with an oxymorphone dosage form and informing the patient or prescribing physician that the bioavailability of oxymorphone is increased in patients with renal impairment. | 2008-12-25 |
20080318995 | N-Substituted Indenoisoquinolines and Syntheses Thereof - N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof. | 2008-12-25 |
20080318996 | 6-Amino(Aza)Indane Compounds Suitable for Treating Disorders that Respond to Modulation of the Dopamine D3 Receptor - The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R | 2008-12-25 |
20080318997 | NOVEL 4-PHENYL SUBSTITUTED TETRAHYDROISOQUINOLINES AND THERAPEUTIC USE THEREOF - Compounds are provided that, by way of their selective neurotransmitter binding useful for the treatment of various neurological and psychological disorders, e.g., ADHD. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein. | 2008-12-25 |
20080318998 | Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines - Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed. | 2008-12-25 |
20080318999 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators - The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: | 2008-12-25 |
20080319000 | Use of 3,1IB-Cis-Dihydrotetrabenazine for the Treatment of Symptoms of Huntingtons Disease - The invention provides 3,11b-cis-dihydrotetrabenazine for use in halting or slowing the progress of one or more symptoms of Huntington's disease in a patient, and more particularly a symptom selected from involuntary movements such as involuntary chorea, tremors and twitches, and degeneration in gait. | 2008-12-25 |
20080319001 | Cancer Treatment Using Specific 3,6,9-Substituted Acridines - The present invention relates to a 3,6,9 acridine compound and optionally substituted derivatives thereof that may be useful in the treatment of cancer. The invention also provides compositions comprising the compounds and uses thereof. Formula (I) wherein each of R | 2008-12-25 |
20080319002 | Xanthine Derivatives a Useful as Muscarinic Receptor Antagonists - This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. | 2008-12-25 |
20080319003 | CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT - A chemical compound represented by the formula [I]: | 2008-12-25 |
20080319004 | DEUTERIUM-ENRICHED CLOPIDOGREL - The present application describes deuterium-enriched clopidogrel, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2008-12-25 |
20080319005 | Phenylacetamides Suitable as Protein Kinase Inhibitors - The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases. | 2008-12-25 |
20080319007 | DEUTERIUM-ENRICHED MONTELUKAST - The present application describes deuterium-enriched montelukast, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2008-12-25 |
20080319008 | Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof - The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ΔF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof. | 2008-12-25 |
20080319009 | Methylene-bridged selective androgen receptor modulators and methods of use thereof - This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell. | 2008-12-25 |
20080319010 | Use of Chloroquine to Treat Metabolic Syndrome - The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption. | 2008-12-25 |
20080319011 | PROTEIN TYROSINE KINASE ENZYME INHIBITORS - This invention provides compounds of formula 1, having the structure | 2008-12-25 |
20080319012 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors - 2-pyridyl-substituted imidazoles which are used advantageously in the treatment of diseases mediated by ALK 5 or ALK 4 receptor or both. | 2008-12-25 |
20080319013 | 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-ONES AND, 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-ONES AND RELATED COMPOUNDS - Compounds of Formula 1 | 2008-12-25 |
20080319014 | Nitroxides for Use in Treating or Preventing Diabetes - Pharmaceutical compositions are provided that are useful in treating diabetes. The compositions comprise a pharmaceutically acceptable carrier, and an effective therapeutic or prophylactic amount of a nitroxide antioxidant that alters the expression of genes related to diabetes. Methods are also provided for the use of the pharmaceutical compositions in the treatment or prevention of diabetes. In a preferred embodiment, the nitroxide antioxidant is Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl). | 2008-12-25 |
20080319015 | Insect Repellent Mixture - The present invention relates to the use of an insect repellent, preferably selected from the group 2-(2-hydroxyethyl)-1-methylpropyl 1-piperidinecarboxylate, N,N-diethyl-3-methylbenzamide, dimethyl phthalate, butopyronoxyl, 2,3,4,5-bis(2-butylene)-tetrahydro-2-furaldehyde, N,N-diethylcaprylamide, N,N-diethylbenzamide, o-chloro-N,N-diethylbenzamide, dimethyl carbate, di-n-propyl isocinchomeronate, 2-ethylhexane-1,3-diol, N-octylbicycloheptenedicarboximide or piperonyl butoxide, particularly preferably 2-(2-hydroxyethyl)-1-methylpropyl 1-piperidinecarboxylate, as action enhancer for a second insect repellent, to corresponding compositions, and to the preparation thereof. | 2008-12-25 |
20080319016 | Novel Arylamidine Derivative, Salt Thereof, and Antifungal Containing These - An arylamidine derivative represented by the general formula (wherein R | 2008-12-25 |
20080319017 | Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators -
The present invention relates to certain novel compounds of the formula (I)
| 2008-12-25 |
20080319018 | ORGANIC COMPOUNDS - The present invention relates to a compound of the formula I | 2008-12-25 |
20080319019 | Therapeutic Agents - The present invention relates to certain 1,2-diarylimidazoles of formula I | 2008-12-25 |
20080319020 | 4-Oxadiazolyl-Piperidine Compounds and Use Thereof -
4-Oxadiazolyl-piperidine compounds of formula (I) and (II), their compositions and use for the treatment of pain and diarrhoea. | 2008-12-25 |
20080319021 | Inhibition Of Phosphoinositide 3-Kinase Beta - The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase β, use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful for the new anti-thrombotic therapy by detecting selective inhibitory activity of PI 3-kinase β of the compound. The invention also relates to novel compounds that are inhibitors of PI 3-kinase. | 2008-12-25 |
20080319022 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors - 2-pyridyl-substituted imidazoles and their use in inhibiting ALK 5 and/or ALK 4 receptors is disclosed. | 2008-12-25 |
20080319023 | Insecticidal Compositions for Control of General Household Pests - The present invention relates to an insecticidal composition comprising a pyrethroid and a second insecticide selected from the group consisting of imidacloprid, nithiazine, thiamethoxam, dinotefuran, nitenpyram, thiacloprid, clothianidin and chlorfenapyr, with significantly improved knockdown and mortality characteristics when applied to general household pests. | 2008-12-25 |
20080319024 | Rosiglitazone Phosphate and Polymorphic Forms - The present invention relates to 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione phosphate, a novel salt of rosiglitazone and to novel polymorphic forms thereof. The invention is also directed to processes for preparation of rosiglitazone phosphate and its polymorphs. The compounds of the invention are useful for treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof. | 2008-12-25 |
20080319025 | Therapeutic and Diagnostic Methods Dependent on CYP2A Enzymes - A method of regulating the activity of human cytochrome P450 isozyme CYP2A6 to control nicotine metabolism or decrease to production of carcinogens from procarcinogens, such as those present in tobacco smoke, in an individual by selectively inhibiting CYP2A6. Various prophylactic (i.e., prevention and treatment) compositions and methods are also described, including an improved oral nicotine composition and method comprising the use of nicotine together with an inhibitor of the CYP2A6 enzyme. | 2008-12-25 |
20080319026 | SUBSTITUTED N-ARYL PYRIDINONES - Disclosed herein are substituted N-Aryl pyridinone fibrotic inhibitors and/or collagen infiltration modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 2008-12-25 |
20080319027 | Composition and Method for Treating Fibrotic Diseases - The present invention discloses 5-methyl-1-(substituted phenyl)-2(1H)-pyridones have enhanced anti-fibrotic activities than 5-methyl-1-(non-substituted phenyl)-2(1H)-pyridones. An representative example of 5-methyl-(1-substituted phenyl)-2(1H)-pyridones is 1-(3′-fluorophenyl)-5-methyl-2(1H)-pyridone. Accordingly, there are provided compositions comprising one or more compounds selected from the group consisting of 5-methyl-1-(substituted phenyl)-2(1H)-pyridones and methods of using the same to treat or prevent fibrosis diseases. | 2008-12-25 |
20080319028 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators - This invention relates to dicycloalkylcarbamoyl ureas of formula (I), which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. | 2008-12-25 |
20080319029 | Bifenthrin/Acetamiprid Compositions for Control of General Household Pests - The present invention relates to an insecticidal composition of bifenthrin and acetamiprid with significantly improved knockdown and mortality characteristics when applied to general household pests. | 2008-12-25 |
20080319030 | SYDNONIMINES - SPECIFIC DOPAMINE REUPTAKE INHIBITORS AND THEIR USE IN TREATING DOPAMINE RELATED DISORDERS - Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake. | 2008-12-25 |
20080319031 | Novel Tyrosine Derivatives - The present invention relates to novel tyrosine derivatives of formula (I), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel tyrosine derivatives of the general formula (I). | 2008-12-25 |
20080319032 | TETRAHYDROBENZOTHIAZOLE ANALOGUES AS NEUROPROTECTIVE AGENTS - This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells. | 2008-12-25 |
20080319033 | Organic Compounds - Compounds of formula I | 2008-12-25 |
20080319034 | METHOD FOR PRODUCING PRECIOUS MATERIAL FOR ORNAMENTAL ARTICLES AND PRECIOUS MATERIAL FOR ORNAMENTAL ARTICLES WHICH CAN BE OBTAINED IN PARTICULAR BY MEANS OF THIS METHOD - Method for producing a precious material for ornamental articles, which envisages introducing, into the plasticization chamber of an extruder at a temperature of between 120 and 220° C., an amount of a Polymer composition and an amount of a metallic powder formed with one or more precious metals having particles with an average size of less than 0.5 micron in order to achieve thorough mixing between the amount of polymer composition in the liquid state and the amount of metallic powder by means of one or more screws provided with mixing segments; and then an extrusion and cutting step in order to obtain an intermediate product with a precious metal content to be treated during a subsequent forming step aimed at obtaining an ornamental article in the desired form. | 2008-12-25 |
20080319035 | Microbicidal composition - Synergistic microbicidal compositions containing N-methyl-1,2-benzisothiazolin-3-one. | 2008-12-25 |
20080319036 | METHOD FOR TREATING OBESITY - The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism. | 2008-12-25 |
20080319037 | 1,2,4-TRIAZOL-1-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMORS - There is provided a compound of Formula I | 2008-12-25 |
20080319038 | PREVENTATIVE OR THERAPEUTIC AGENT FOR ACUTE RENAL FAILURE - An agent for prevention and treatment of acute renal failure comprising a hydantoin derivative represented by the general formula below as an active ingredient. One example of such compounds is (2S, 4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′imidazolidine]-2-carboxamide. | 2008-12-25 |
20080319039 | UNIT DOSAGE FORMS OF TEMOZOLOMIDE - This invention relates to unit dosage forms of temozolomide. These unit dosage forms are particularly well-suited for decreasing the pill burden and increasing patient compliance. The invention also relates to methods of treating proliferative disorders in a patient with these unit dosage forms. The invention additionally relates to kits comprising these unit dosage forms. | 2008-12-25 |
20080319040 | N-Acylic Aminoacid Derivatives, Method For The Production Thereof, Pharmacological Composition And The Use In The Form Anti-Allergic, Anti-Inflammatory And Hypolipidemic Agents - The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof | 2008-12-25 |
20080319041 | Lofexidine enantiomers for use as a treatment for CNS disease and pathologies and its chiral synthesis - The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine. | 2008-12-25 |
20080319042 | Compositions and methods for treatment of liver disease - The present invention comprises compositions and methods for the treatment of liver disease, particularly treatments for infection by HCV and/or HBV. The present invention comprises antiviral compositions comprising lamiridosin, derivatives of lamiridosin or iridoids that are effective in inhibiting one or more steps in the infection of cells by HCV or HBV. Methods for treating subjects, particularly humans, infected with HCV or HBV are provided. | 2008-12-25 |
20080319043 | 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists - The present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. | 2008-12-25 |
20080319044 | Compounds and Methods of Use Thereof - Indole boronic acid compounds, and analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) in a subject in need thereof. | 2008-12-25 |
20080319045 | Combination of Histone Deacetylase Inhibitors and Radiation - This invention relates to organic compounds of formula (I): | 2008-12-25 |
20080319046 | SUBSTITUTED SULFONAMIDE-INDOLES - The present invention relates generally to substituted sulfonamide indoles such as substituted sulfonamide indoles, and methods of using them. | 2008-12-25 |
20080319047 | Novel Glucitol Derivative, Prodrug Thereof And Salt Thereof, And Therapeutic Agent Containing The Same For Diabetes - The invention provides a glucitol derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity; and a medicinal composition for use in the prevention or treatment of diseases attributable to hyperglycemia, such as diabetes, complications of diabetes, and obesity. The derivative is a compound represented by the formula (I): | 2008-12-25 |
20080319048 | Solubilized formulation of docetaxel without tween 80 - Lyophilizates containing docetaxel and the use thereof in preparing concentrated liquid formulations, and ready to use formulations for injection, as well as such concentrates and ready to use formulations themselves are disclosed in which Tween surfactants are avoided so that hypersensitivity reactions to Tween surfactants can be avoided and docetaxel can be administered at higher doses and/or for longer periods of time and/or for additional treatment cycles. | 2008-12-25 |
20080319049 | Compounds For the Treatment of Metabolic Disorders - Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R | 2008-12-25 |
20080319050 | Preparation Containing Oxidized Flavonoid Derivatives - The invention relates to novel compositions, in particular cosmetic and/or pharmaceutical compositions or food supplements, comprising at least one oxidised flavonoid derivative of the formula I, to novel oxidised flavonoid derivatives, and to novel uses of the oxidised flavonoid derivatives. | 2008-12-25 |
20080319051 | LIQUIRITIGENIN AND DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR BETA AGONISTS - The disclosure provides compositions comprising liquiritigenin, or derivatives, or prodrugs, useful as estrogen receptor beta selective agonists. The disclosure also provides methods of treating menopausal symptoms, and estrogen-dependent disorders, with said compositions. | 2008-12-25 |
20080319052 | Lipopexia Inhibitor and Food or Beverage - [Problems] To provide a lipopexia inhibitor being effective for the inhibition of fat accumulation. | 2008-12-25 |
20080319053 | Anthocyanin pigment/dye compositions through corn extraction - Anthocyanin pigments/dyes are extracted from corn kernels by adding corn kernels with less than 5% by weight of corn kernels comprising broken kernels to an aqueous medium to form an aqueous-corn medium. The corn kernels have in excess of 0.1 mg of anthocyanin pigment/dye per gram of corn kernel therein. The anthocyanin pigment/dye in the corn kernels has greater than 40% by weight of anthocyanin as an acid or acylated form of the anthocyanin. The aqueous corn medium is agitated at a temperature above 35° C. The solid corn kernels are separated from the aqueous corn medium to form an extract of anthocyanin in aqueous medium having less than 1.0% solids therein before concentration or purification steps are performed on the extract. | 2008-12-25 |
20080319054 | Treatment of Cancer - The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions. | 2008-12-25 |
20080319055 | Cooling Compounds - A method of providing a cooling sensation to the skin or the mucous membranes of the body by applying thereto a compound of Formula I | 2008-12-25 |
20080319056 | Butylphthalide Self-Emulsifying Drug Delivery System, Its Preparation Method and Application - The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delivery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug. | 2008-12-25 |
20080319057 | 2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators - 2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R | 2008-12-25 |
20080319058 | Skin Care Products, As Well As Foods And Beverages Containing 6-O-Pufa Ascorbic Esters - Skin care products which contain as a vitamin C component 6-O-PUFA ascorbates represented by general formula (I): | 2008-12-25 |
20080319059 | Caffeic Acid Derivative and Composition Containing the Same - A caffeic acid derivative can be denoted by the chemical formula 1 below. | 2008-12-25 |
20080319060 | COMPOSITION CONTAINING VITAMIN C - The present invention relates to a composition containing vitamin C. The composition according to the present invention includes cationic material and anionic material as a primary stabilizing agent of the vitamin C; and a caffeic acid derivative as a secondary stabilizing agent of the vitamin C. The caffeic acid derivative is water-soluble and, preferably, a new caffiec acid derivative as denoted by the chemical formula 1 below is used. According to the present invention, the cationic material and the anionic material generate an electrical double layer to stabilize the vitamin C primarily; water-soluble caffeic acid derivative stabilizes the vitamin C secondarily. Accordingly, the vitamin C is stabilized double so that the vitamin C is protected from being oxidized by air, heat and moisture. | 2008-12-25 |
20080319061 | Process for the Preparation of an Oxaliplatin Preparation - The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy. | 2008-12-25 |
20080319062 | DISINFECTANT AND METHOD OF USE - A non-toxic environmentally friendly aqueous disinfectant is disclosed for specific use as prevention against contamination by potentially pathogenic bacteria, fungi and virus. The aqueous disinfectant is formulated by electrolytically generating silver ions in water in combination with a citric acid. The aqueous disinfectant has many potential uses including bacteria, fungus and viral treatment, water treatment, medical treatment as well as for preserving consumable and non-consumable products. | 2008-12-25 |
20080319063 | CURING ACCELERATOR AND METHOD OF MAKING - A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue. | 2008-12-25 |
20080319064 | DEUTERIUM-ENRICHED OSELTAMIVIR - The present application describes deuterium-enriched oseltamivir, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2008-12-25 |
20080319065 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release - Phospholipase A | 2008-12-25 |
20080319066 | Jasmonate Derivative Compounds, Pharmaceuticals Compounds and Methods of Use Thereof - The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of cancers, especially mammalian cancers. | 2008-12-25 |
20080319067 | 2-Hydroxy-6-phenylphenanthridines as PDE-4 inhibitors - The compounds of formula I | 2008-12-25 |
20080319068 | Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same - A polymer of aspirin is provided by the present invention. Methods of making and using the same are also provided. | 2008-12-25 |
20080319069 | Spider esters in personal care applictions - The present invention is drawn to a process for providing emolliency to the skin using a series so called “spider esters”. These esters are derived from poly-hydroxy functional compounds sequentially reacted with ethylene oxide or propylene oxide, followed by the reaction of the alkoxylate with fatty acid. The resulting products are called spider esters because they resemble the spider, wherein appendages are alkoxylated esters. The restrictions this orientation imposes on rotation allows for the preparation of polar esters that have little or no water solubility, and provide both moisturization to the skin and emolliency by reducing transepidermal water loss. | 2008-12-25 |
20080319070 | Sanitizing and Cleaning Composition and its Use for Sanitizing and/or Cleaning Hard Surfaces - The present invention relates to acidic sanitizing and/or cleaning compositions comprising a specific quaternary antimicrobial system consisting of C1-C4 hydroxyalkyl carboxylic acids, C5-C18 alkyl monocarboxylic acids, unsubstituted or substituted, saturated or unsaturated C4-dicarboxylic acids and additional inorganic or organic acids. The compositions of the present invention can be present in the form of concentrates and in the form of diluted use solutions. They can be used in a process for sanitizing and/or cleaning hard surfaces, preferably in a cleaning-in-place (CIP) and/or sanitize-in-place (SIP) process for cleaning and/or sanitizing plants in the food, dairy, beverage, brewery and soft drink industries. | 2008-12-25 |
20080319071 | Novel Nutraceutical and Pharmaceutical Compositions and Use Thereof for the Treatment, Co-Treatment or Prevention of Inflammatory Disorders - The present invention relates to new methoxylated aromatic compounds. It also relates to novel compositions comprising methoxylated aromatic compounds as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders. | 2008-12-25 |
20080319072 | COMPOSITION AND METHOD FOR TREATING BACTERIAL, VIRAL, FUNGAL DISEASES, INFLAMMATION AND PAIN - The present invention is directed to compositions and methods of treating bacterial, viral, fungal diseases; inflammation or inflammatory-related disorders; pain; and skin conditions. The composition comprises an organic solvent extract, which is prepared by the method comprising the steps of: (a) mixing methionine with water, (b) adding an aqueous hypochlorite solution to the methionine solution and mixing, (c) adding a water-immiscible organic solvent to (b) and mixing, and (d) separating the organic solvent phase from the water phase to obtain the organic solvent extract. The present invention is also directed to a method for preparing the organic solvent extract. | 2008-12-25 |
20080319073 | COLONIC DELIVERY THERAPEUTIC AGENTS FOR INFLAMMATORY BOWEL DISEASE - The present invention discloses a therapeutic agent for inflammatory bowel disease, which is in the from of delivering 1 to 5 g of glutamine to the large intestine per one administration; and the therapeutic agent for inflammatory bowel disease with which an anti-inflammatory agent(s) is combined. This therapeutic agent for inflammatory bowel disease can safely and effectively treat inflammatory bowel disease including ulcerative colitis without increasing the frequency of bowel movements. | 2008-12-25 |
20080319074 | Glucagon Receptor Antagonists, Preparation and Therapeutic Uses - The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like. | 2008-12-25 |
20080319075 | Polymorphic forms of nateglinide - Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration. | 2008-12-25 |
20080319076 | COMPOSITIONS COMPRISING CREATINE SALTS AND METHODS OF USE THEREOF - The invention relates to compositions (e.g., nutritional supplements) comprising, consisting essentially of, or consisting of a creatine bicarbonate, and to methods of making and using said compositions. | 2008-12-25 |
20080319077 | Remedy for Diabetes - The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided. | 2008-12-25 |
20080319078 | Triphenylethylene Compounds Useful as Selective Estrogen Receptor Modulators - Triphenylethylene compounds of formula (I) are provided. The compounds are particularly useful for selective estrogen receptor modulation. | 2008-12-25 |
20080319079 | Method for Administering Formoterol Using a Nebulizer - The present invention provides a method of administering formoterol, for example as a fumarate dihydrate, using a nebulizer device for the treatment of bronchoconstriction, such as that caused by asthma and chronic obstructive pulmonary disease. The method of this invention is particularly useful in pediatric, geriatric, handicapped and acutely ill individuals who have been denied the benefits of this medication due to the standard use of dry powder inhalers. The present invention addresses the difficulty of making available a viable commercial nebulizer solution for these individuals who cannot optimally use powder inhaler devices, which are the only presently available delivery systems for this medication. | 2008-12-25 |
20080319080 | Amide Compounds and Their Use - Since an amide compound represented by the formula (1) | 2008-12-25 |
20080319081 | Insecticidal Compositions Having Improved Effect - The present invention relates to increasing the activity of crop protection compositions comprising phthalic acid diamides through the addition of ammonium salts and/or phosphonium salts or through the addition of ammonium or phosphonium salts and penetrants, to the corresponding compositions, to processes for preparing them and to their use in crop protection. | 2008-12-25 |
20080319082 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives - Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumour, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumours. | 2008-12-25 |
20080319083 | MEDICINE FOR TRANSNASAL ADMINISTRATION - The object is to provide an SNRI-containing preparation which has a higher absorbability compared to a conventional SNRI preparation, produces its effect rapidly, and is readily administered to a patient who is hard to be administered via an oral route. | 2008-12-25 |
20080319084 | Wrinkling Prevention or Remedy with Adam Activity Inhibiting Substance - A composition contains a substance, which is capable of inhibiting activity of ADAM (a disintegrin and metalloprotease) present in a skin, in a proportion efficient for preventing or remedying wrinkling. Wrinkling is prevented or remedied with a method comprising the step of applying a substance, which is capable of inhibiting activity of ADAM present in a skin, to the skin. Anti-wrinkling effects are evaluated with a method wherein enzymatic activity or a gene expression level of ADAM in a skin, a skin tissue, or cells is used as an index. | 2008-12-25 |
20080319085 | TITRATION DOSING REGIMEN FOR CONTROLLED RELEASE TRAMADOL - A titration dosing regimen for the administration of controlled release tramadol analgesic to patients. The titration dosing regimen provides a significant reduction in the occurrence of adverse effects from the introduction of controlled released tramadol dosing, thus increasing patient compliance and medication tolerability. | 2008-12-25 |
20080319086 | DEUTERIUM-ENRICHED SALMETEROL - The present application describes deuterium-enriched salmeterol, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. | 2008-12-25 |
20080319087 | Use of Ambroxol for the Treatment of Rhinovirus Infections - The invention is directed to the use of ambroxol or pharmaceutically acceptable salts thereof for preparing a medical composition for treating or preventing infections caused by human rhinovirus. Surprisingly it was found that Ambroxol is capable to suppress the replication of human rhinovirus. Therefore, the ambroxol-containing medical composition is suitable to treat or prevent against all symptoms of a rhinovirus infection and provides a direct antivirale effect. | 2008-12-25 |
20080319088 | Aldehyde Compositions and Methods for Providing Fragrance Containing the Same - The present invention is directed to the novel aldehyde compounds, represented by the general structure of Formula I set forth below: | 2008-12-25 |
20080319089 | Method of colouring carrier materials - The present invention relates to a method of producing coloured carrier particles which comprises which comprises: | 2008-12-25 |
20080319090 | Pearlizer concentrate and its use in personal care compositions - An aqueous pearlescent concentrate, containing a pearlizing agent, an anionic surfactant, and a cationic component, having increased opacity and is useful in modifying the appearance of aqueous liquid compositions, particularly personal care compositions. | 2008-12-25 |
20080319091 | Polymer Derivatives Comprising an Imide Branching Point - The invention provides a water-soluble polymer comprising (i) an imide group comprising a linking nitrogen atom, a first carbonyl group covalently attached to the linking nitrogen atom, and a second carbonyl group covalently attached to the linking nitrogen atom; (ii) a first water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the first carbonyl group of the imide group and (iii) a second water-soluble polymer segment covalently attached, either directly or through one or more atoms, to the second carbonyl group of the imide group. The invention also provides, among other things, methods for preparing polymers, conjugates, pharmaceutical compositions and the like. | 2008-12-25 |
20080319092 | Transdermal Drug Delivery Formulation - The present invention provides a transdermal formulation for the delivery of at least one active agent. The formulation includes (i) a first compound comprising an organic sulfoxide, and (ii) a second compound selected from the group consisting of a fatty acid ester, a fatty acid, an azone-related compound and mixtures thereof. | 2008-12-25 |
20080319093 | CONVERSION OF CARBON DIOXIDE TO METHANOL AND/OR DIMETHYL ETHER USING BI-REFORMING OF METHANE OR NATURAL GAS - The invention discloses a method of converting carbon dioxide to methanol and/or dimethyl ether using any methane source or natural gas consisting of a combination of steam and dry reforming, in a specific ratio to produce a 2:1 molar ratio of hydrogen and carbon monoxide with subsequent conversion of the CO and H | 2008-12-25 |
20080319094 | PROCESS FOR MAKING FISCHER-TROPSCH OLEFINIC NAPHTHA AND HYDROGENATED DISTILLATES - A process is described by which an olefinic naphtha and a hydrogenated distillate fuel are made from a Fischer-Tropsch process. The olefinic naphtha is suitable for use in an ethylene cracker where the olefins enhance the formation of ethylene. Thy hydrogenated distillate fuel is used in jet and or diesel fuels. Optionally the olefinic naphtha has a low content of acids. This low acid content, is obtained by operating the Fischer-Tropsch unit at H | 2008-12-25 |