52nd week of 2012 patent applcation highlights part 45 |
Patent application number | Title | Published |
20120329017 | Method and system of coaching behavior - A method of coaching behavior by using at least one interactive device, including the steps of: (a) creating a profile through the interactive device, wherein the profile contains at least one type of information, wherein the profile is shown to other peers through a predetermined communication network, (b) setting an objective in relation to the type of information in the interactive device, (c) delivering a push notification to the user through the interactive device, (d) generating a corresponding change to the profile to be shown in the interactive device, wherein when the request is not fulfilled, a negative effect is generated in the profile as the change of the profile, and when the request is substantially fulfilled, a positive effect is generated in the profile as the change of the profile, and (e) receiving feedback from the peers through the communication network in response to the change of the profile. | 2012-12-27 |
20120329018 | RESPONSE SCORING SYSTEM FOR VERBAL BEHAVIOR WITHIN A BEHAVIORAL STREAM WITH A REMOTE CENTRAL PROCESSING SYSTEM AND ASSOCIATED HANDHELD COMMUNICATING DEVICES - A system, method and related devices for monitoring and improving the training and social eye contact and communication skills of developmentally challenged individuals such as autistic individuals with special needs in improving their interpersonal communicating and other skills. A WatchMe component of the system and method monitors and obtains qualitative and quantitative information about the eye contact habits of a subject being trained or interviewed. It provides stimuli that promotes and encourages improvements in the eye contact habits of the subject. | 2012-12-27 |
20120329019 | Biblical Guidance and Training Method - A method of mentoring groups of individuals in the effort to develop their relationship with God, as well as to train and develop their athletic skills while employing a unique player identification system based on biblical scripture numerals. The participants are divided into groups based on age and spiritual progression, as well as athletic training level, and are labeled according to religious scriptures and figures which correlate to the growth of the participants in their athletic training, as well as their progression towards God and a pious life. | 2012-12-27 |
20120329020 | SYSTEMS AND METHODS FOR PRESONALIZED FATIGUE EDUCATION AND RISK MANAGEMENT - A method is provided for ascertaining personalized education information related to one or more fatigue-related individual traits of a subject. The method involves: receiving first input data indicative of an expression of one or more fatigue-related individual traits of the subject; estimating trait values for the one or more fatigue-related individual traits, wherein estimating the trait values comprises: using the first input data and a fatigue model, which relates a fatigue level of the subject to a set of model parameters, to estimate values for the set of model parameters; and evaluating one or more trait-estimation functions using the estimated values for the set of model parameters; and determining personalized education information about the one or more fatigue-related individual traits of the subject based on the estimated trait values. | 2012-12-27 |
20120329021 | Customizable Fitness System - A workout system configured to increase the ease of determining a proper workout by any user and guiding said user through the workout safely. A series of color coded anatomical images displays muscles and muscle groups. The color coded anatomical images correlate directly to a plurality of body regions and provide guidance to muscles being used in each exercise. Photographs and descriptions accompany each exercise so said users may see how to perform the exercise correctly. Icons provide guidance regarding any equipment that may be used to perform the exercises and barcodes may be used to link the exercises to instructional videos. Besides being color coded, each exercise, body region, and muscles used are also labeled. The composite effect of these elements allow for workouts that can be developed by body region, muscles impacted, full body workout, or a random workout. | 2012-12-27 |
20120329022 | CHEST COMPRESSION TRAINING ASSEMBLY - A chest compression training assembly comprising an upper portion and a lower portion, wherein the upper portion is adapted to be moved towards the lower portion when a compression force is exerted on the upper portion, and to move back to a noncompressed position when the compression force is removed. An upper element is connected to the upper portion and a lower element is connected to the lower portion, wherein the upper and lower elements both contain a magnetic material and are facing each other. At least one of the upper and lower element comprises a magnet. At least one of the upper and lower element is arranged on an element retainer permitting the upper or lower element to move within a predetermined path towards the facing upper or lower element. The upper and lower element are arranged in such way that one may be moved into a certain proximity of the other during a compression movement of the top of the assembly. Magnetic attraction between the upper and lower elements results in acceleration, within said path, of one of the upper and lower elements towards the other when in said proximity, wherein said acceleration results in a collision which produces an audible sound. | 2012-12-27 |
20120329023 | MANIKIN WITH SIMULATION OF AGONAL BREATHING - The present invention provides a manikin comprising a chest area and a head, for training of cardiopulmonary resuscitation (CPR). The manikin is distinctive in that it comprises a means for providing gasping movements of the head, and a means for simulating the sound of agonal breathing, which means are operatively connected to a device for actuating said means, for simulation of agonal breathing. | 2012-12-27 |
20120329024 | Educational and Recreational Device - The device comprises a ball and a panel that is made in the form of a periodic corrugation. The amplitude of the corrugation at least 10 times smaller than the period of corrugation, and the ball has a diameter which is at least 10 times smaller than the period of corrugation. Corrugations of the panel can be made sinusoidal, trapezoidal, triangular, or have other more complex forms. The device can be provided with a means for throwing the ball at different angles to the plane of the panel and at different initial velocities. The technical result obtained when using the claimed invention is a device that has broad potential as a visual aid in learning the peculiarities of motion of bodies under the action of external forces. | 2012-12-27 |
20120329025 | METHODS FOR RECORDING AND DETERMINING A CHILD'S DEVELOPMENTAL SITUATION THROUGH USE OF A SOFTWARE APPLICATION FOR MOBILE DEVICES - Systems and methods for measuring and improving a young child's mental abilities on a tablet computer. A user of the tablet computer is prompted for the child's age and, based on the age, the expected performance or abilities of the child are provided. The child can be assessed using a number of activities whereby the child identifies and/or matches various objects. The assessment can be done by timing the activity to completion, determining how many errors/tries were needed to complete the activity, or any other number of assessment techniques. The child's performance is then compared against expected metrics for children of a similar age. The activities can range from games that involve identifying everyday objects to the introduction of mathematical concepts and numbers to identifying and/or matching animals. | 2012-12-27 |
20120329026 | SYSTEMS AND METHODS FOR PROVIDING LEARNERS WITH AN ALTERNATIVE TO A TEXTBOOK OR SIMILAR EDUCATIONAL MATERIAL - System and method for providing new educational material to one or more learners comprising analyzing the words or images used in one or more items of original educational material to determine the topics covered in the original educational material, identifying the topics covered in the original educational material, identifying the order in which the topics are presented in the original educational material, creating a list of the topics covered in the original educational material and the order in which they are presented, searching available databases and publically known sources for content on the topics covered in the original educational material, compiling the content on the topics covered in the original educational material to create a new educational material that covers the topics of the original educational material and providing or providing access to the new educational material to one or more learners. | 2012-12-27 |
20120329027 | SYSTEMS AND METHODS FOR A LEARNER INTERACTION PROCESS - System and method for a learner interaction process comprising receiving information regarding one or more learners, receiving information regarding the educational material that the one or more learners would like to learn, presenting more than one question regarding the educational material prior to presenting the educational material to the one or more learners, receiving answers to the more than one questions presented to the one or more learners, presenting the educational material to the one or more learners, identifying the amount of time the one or more learns reviewed the educational material, presenting and receiving answers to more than one question regarding the educational material that the one or more learners has reviewed after the educational material has been presented to the one or more learners, and determining whether the one or more learners learned the educational material presented based on the one or more learners answers to the questions. | 2012-12-27 |
20120329028 | METHOD FOR INTELLIGENT PERSONALIZED LEARNING SERVICE - In a method of offering an intelligent personalized learning service to learning participants, a pointer is assigned to each learning object and associated with each learning object belonging to a learning object database. A learning subject specific to each learning participant is selected from a learning subject database. Information on attempts at the learning objects associated with selected learning subject is recorded on learning history information of each learning participant. Performance completion information is recorded with respect to the learning objects attempted by the learning participant on the learning history information of each learning participant. A proficiency status of the learning participant is diagnosed for the selected learning subject corresponding to the learning participant based on the learning history information of each learning participant. | 2012-12-27 |
20120329029 | COMPUTER IMPLEMENTED TEACHING METHOD AND APPARATUS - A computer implemented method for teaching subject matter includes the steps of generating an assignment including one or more questions, providing the assignment to one or more students, recording a final answer to each of the one or more questions and one or more steps taken to reach the final answer, and grading the assignment. A computer implemented system of teaching subject matter to one or more students includes an assignment generating station operable to generate an assignment including one or more questions, a testing station operable to administer the assignment to one or more students and record an answer to each of the one or more questions and steps taken to reach the answer, and a grading station operable to grade the answer and steps taken to reach the answer. | 2012-12-27 |
20120329030 | SYSTEM AND METHOD OF KNOWLEDGE ASSESSMENT - A system and method of knowledge assessment provides for a computer-executable program capable of generating a user's knowledge profile based on answers to queries posed to the user via a communication network. The user's knowledge profile can be used for creating a detail curriculum in a specific academic subject for the user to pursue or for comparing with the knowledge profile of one or more other users. The detail curriculum, or knowledge path, arranges the subjects to be learned in a hierarchical manner so that the user can determine which subject categories must be mastered before moving to other categories and concepts. | 2012-12-27 |
20120329031 | INFORMATION DISPLAY APPARATUS AND INFORMATION DISPLAY METHOD - An information display apparatus includes a display control unit configured to control display of a question that is received and then stored; a request receiving unit configured to receive a display request to display the question; a generating unit configured to generate a schedule table in which an order of displaying questions and display durations of the respective questions are associated with each other so that a sum of the display durations of the questions becomes equal to or shorter than a question-and-answer time indicating a predetermined duration of a question-and-answer session; and a notifying unit configured to issue a notice of a timing at which each display duration ends based on the schedule table. The display control unit switches display of the questions in accordance with the order. When a predetermined condition is satisfied after the schedule table is generated, the generating unit adjusts the schedule table. | 2012-12-27 |
20120329032 | SCORING CANDIDATES USING STRUCTURAL INFORMATION IN SEMI-STRUCTURED DOCUMENTS FOR QUESTION ANSWERING SYSTEMS - A system, program product, and methodology automatically scores candidate answers to questions in a question and answer system. In the candidate answer scoring method, a processor device performs one or more of receiving one or more candidate answers associated with a query string, the candidates obtained from a data source having semi-structured content; identifying one or more documents with semi-structured content from the data source having a candidate answer; and for each identified document: extracting one or more entity structures embedded in the identified document; determining a number of the entity structures in the identified document that appear in the received input query; and, computing a score for a candidate answer in the document as a function of the number Overall system efficiency is improved by giving the correct candidate answers higher scores through leveraging context-dependent structural information such as links to other documents and embedded tags. | 2012-12-27 |
20120329033 | BEAUTY-RELATED INFORMATION COLLECTION AND DIAGNOSIS USING ENVIRONMENTS - Features and principles of the present invention relate to a method of generating a beauty-related diagnosis for an individual. The method may comprise collecting personal beauty care information, and generating a beauty-related diagnosis according to the collected information. Collecting may comprise causing a presentation of an environment associated with personal beauty care information to be collected, and receiving the personal beauty care information. The personal beauty care information may correspond to at least one object in the environment. | 2012-12-27 |
20120329034 | Method For Producing An Acellular Dermal Matrix, And Acellular Dermal Matrix Produced By Same - The present invention relates to a method for producing an acellular dermal matrix, and to an acellular dermal matrix produced by same, and more particularly, to a method for producing an acellular dermal matrix, in which sucrose is added to base ingredients consisting of glycerol, propylene glycol, and a base solvent or solution so as to produce a cryoprotectant, the solution is injected into the skin below the epidermis and dermis from which cells have been removed, and freeze-drying is then performed. | 2012-12-27 |
20120329036 | COMPOSITIONS AND METHODS FOR THE STORAGE OF RED BLOOD CELLS - The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions. | 2012-12-27 |
20120329037 | BIOSENSOR - Embodiments of the present disclosure set forth a biosensor for detecting a target. One example sensor includes a first electrode. The first electrode includes a first electron conducting molecule and a first probe. The first probe includes a second electron conducting molecule. The first probe is configured to bind to the target of interest in solution. The first and second electron conducting molecules are different. | 2012-12-27 |
20120329038 | Multivolume Devices, Kits and Related Methods for quantification of Nucleic Acids and Other Analytes - Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest. | 2012-12-27 |
20120329039 | SUBSTANCE DETERMINING APPARATUS - The invention relates to a substance determining apparatus for determining a substance within a fluid. Particles attach the substance and bind to a binding surface ( | 2012-12-27 |
20120329040 | MICROFLUIDIC DEVICES AND METHODS FOR SEPARATING AND DETECTING CONSTITUENTS IN A FLUID SAMPLE - Microfluidic devices and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a separation medium having functional groups which covalently bond to one or more analytes of interest, e.g., proteins, in a sample upon application of an applied stimulus, e.g., light. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 2012-12-27 |
20120329041 | REAL-TIME PCR POINT MUTATION ASSAYS FOR DETECTING HIV-1 RESISTANCE TO ANTIVIRAL DRUGS - Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID NOS:1-89, and 96-104. Also provided are the oligonucleotides consisting of the nucleotides as set forth in SEQ ID NOS:1-89, and 96-104. Each of the disclosed oligonucleotides is a probe or a primer. Also provided are mixtures of primers and probes and for use in RT-PCR and primary PCR reactions disclosed herein. Provided are methods for the specific detection of several mutations in HIV. Mutations in both the reverse transcriptase and the protease of HIV can be detected using the methods described herein. | 2012-12-27 |
20120329042 | METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING USING ENERGY TRANSFER DETECTION - Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule. | 2012-12-27 |
20120329043 | ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH SOURCE FOLLOWER AMPLIFIER - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2012-12-27 |
20120329044 | ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH CORRELATED DOUBLE SAMPLING - Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions. | 2012-12-27 |
20120329045 | RISK ASSESSMENT FOR PHENYTOIN-INDUCED ADVERSE DRUG REACTIONS - A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including CYP2C9, CYP2C19, CYP2C8 and CYP2C18), HLA alleles (including HLA-A*0207, HLA-A*2402, HLA-B*1301, HLA-B*1502, HLA-B*4001, HLA-B*4609, HLA-B*5101, HLA-DRB1*1001 or HLA-DRB1*1502) and phenytoin concentration in the patient's plasma can all contribute to phenytoin-induced ADRs. | 2012-12-27 |
20120329046 | MOLECULAR MARKER FOR EVALUATING PATHOLOGICAL CONDITIONS AND TREATMENT OF MUSCULAR DYSTROPHY - Novel markers associated with the development of muscular dystrophy that elucidate the mechanisms of muscular dystrophy development and provide a means for diagnosis and treatment of muscular dystrophy are presented. The expression level of one or more markers selected from the group consisting of c-Fos, EGR1, IL-6, and IL-8 in a sample obtained from the subject can be compared with a reference value to diagnose muscular dystrophy in the subject. | 2012-12-27 |
20120329047 | METHODS AND ASSAYS FOR THE DETECTION OF ALTERNATIVE LENGTHENING OF TELOMERES (ALT) ACTIVITY IN CELLS - The invention relates to methods and assays for the detection of active Alternative Lengthening of Telomeres (ALT) activity in cells. The methods and assays involve detecting or assaying for partially double-stranded telomeric circles wherein the presence of said circles is specific for cells comprising an active ALT mechanism. In some embodiments the methods find application in, inter alia, determining the level of ALT activity in a cell, determining the ALT status of a cancer in a subject, diagnosing and/or treating disease, determining disease status, analysis of treatment efficacy, and the identification of novel therapeutic agents. | 2012-12-27 |
20120329048 | AUTHENTICATION METHOD OF DAIRY PRODUCTS - The present invention relates to a new method of establishing the authenticity and origin of dairy products, more specifically to the use of lactic acid bacterial strains having strain-specific insertion sequence elements as tools for marking dairy products (such as cheese) and identification thereof. The invention also extends to new lactic acid bacterial strains, their use in the production of dairy products as well as the dairy products containing these bacterial strains. | 2012-12-27 |
20120329049 | BCR-ABL1 SPLICE VARIANTS AND USES THEREOF - The present invention is based on BCR-ABL1 splice variants which result from insertion and/or truncation of the BCR-ABL1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib. | 2012-12-27 |
20120329050 | METHODS FOR THE DETECTION OF MICROORGANISMS - Presented herein are methods for the detection of the presence or absence of one or more microorganisms in a sample. The method deploys a plurality of probe sets to detect a plurality of microorganisms. The probes in the probe set are detectably labeled. At least one probe set has probes labeled with a combination of detectable labels. The number of detectable labels used in the plurality of probe sets numbers less than the number of microorganisms being detected by the probe set. | 2012-12-27 |
20120329051 | METHODS OF EVALUATING CELLS AND CELL CULTURES - Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some embodiments, the invention involves identifying cell culture composition or the identity of a cell based on expression level of a fibroblast marker. In other embodiments, the invention involves comparing expression levels of at least one chondrocyte marker and at least one fibroblast marker in a cell culture sample or in an individual cell. In illustrative embodiments, the chondrocyte marker is hyaluronan and proteoglycan link protein 1 (HAPLN1), and the fibroblast marker is microfibrillar associated protein 5 (MFAP5). | 2012-12-27 |
20120329052 | IDENTIFICATION OF A DNA VARIANT ASSOCIATED WITH ADULT TYPE HYPOLACTASIA - The present invention relates to a nucleic acid molecule comprising a 5′ portion of an intestinal lactase-phlorizine hydrolase (LPH) gene contributing to or indicative of the adult-type hypolactasia. The present invention further relates to methods for testing for the presence of or predisposition to adult-type hypolactasia that are based on the analysis of an SNP contained in the above recited nucleic acid molecule. Additionally, the present invention relates to diagnostic composition and kit useful in the detection of the presence of or predisposition to adult-type hypolactasia. | 2012-12-27 |
20120329053 | MicroRNA Fingerprints During Human Megakaryocytopoiesis - Described herein is a method of decreasing expression of HOXA1 in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject. | 2012-12-27 |
20120329054 | METHOD AND SUBSTANCES FOR ISOLATING MIRNAS - A capture probe suitable for use with a method for isolating miRNAs. A method for isolating an miRNA of interest from a sample comprising the miRNA of interest comprising providing the capture probe. A method for identifying an miRNA of interest. | 2012-12-27 |
20120329055 | USE OF ALPHA1G SUBUNIT OF T-TYPE CALCIUM CHANNEL AS DIAGNOSTIC MARKER FOR PREGNANCY IN CATTLE - The present invention relates to a marker composition for pregnancy diagnosis in cattle, a pregnancy diagnosis composition, and a pregnancy diagnosis method, which use a pregnancy-specific protein in cattle. The present inventors discovered an α1G subunit protein of the T-type calcium channel expressed specifically in pregnant cows, and produced a specific antibody against this protein. Therefore, the present invention has the effect of detecting pregnancy in cows easily, quickly, and accurately early in the pregnancy. | 2012-12-27 |
20120329056 | METHODS OF EVALUATING RELAPSE RISK OF ACUTE MYELOID LEUKEMIA USING NUCLEIC ACIDS OR FRAGMENTS ENCODING FLT3 KINASE - Aspects of the present application relate to nucleic acids and proteins having a tandem duplication mutation in a juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) that are useful for pathological diagnosis and evaluation of leukemia. Also described are methods of detecting tandem duplication mutations in FLT3 kinase and methods of diagnosing and characterizing leukemia based on the presence of a tandem duplication mutation in a juxtamembrane domain of FLT3 kinase. | 2012-12-27 |
20120329057 | BEEF-SPECIFIC AGE DETERMINATION MARKER CONTAINING THE P21 PROTEIN - The present invention relates to a beef-specific age determination marker containing the p21 protein, to a beef-specific age determination kit containing an antibody which is specifically bound to the p21 protein, and to a method which involves detecting the p21 protein through an antigen-antibody binding reaction using an antibody which is specifically bound to the p21 protein serving as a beef-specific age determination marker in the muscle tissue of beef, so as to determine the age of the beef. According to the present invention, the p21 protein is significantly greatly expressed in the muscle tissue of beef, the age of which is lower than 30 months, and is hardly expressed in the muscle tissue of beef, the age of which is greater than 30 months, and thus can be valuably used as a beef-specific age determination marker. | 2012-12-27 |
20120329058 | METHOD AND DEVICE FOR FAST DETECTING NUCLEIC ACID - The invention belongs to the field of medical detection and discloses a method and device for fast detecting nucleic acid. The pathogenic microorganism nucleic acid is carried out with amplification reaction by LAMP technology in a temperature-controlled reaction tube comprising at least a sealing layer, and after the reaction is completed, the temperature of the reaction tube is raised without opening the tube to dissolve the sealing layer to release the fluorescent dye for the fluorescence detection. The method can carry out the amplification reaction and fluorescence detection directly in the instrument without taking out the reaction tube. The device has advantages of simple structure, low cost and simple operation, and can be used as a fast detecting device for the pathogenic microorganism nucleic acid. | 2012-12-27 |
20120329059 | METHOD FOR CONSTRUCTING NOVEL BACTERIUM BELONGING TO THE GENUS BIFIDOBACTERIUM - A method for producing bacteria belonging to the genus | 2012-12-27 |
20120329060 | DIAGNOSTIC FOR LUNG CANCER USING MIRNA - The invention provides a method for diagnosis of lung cancer, in particular, non-small cell lung cancer using circulating levels of miRNA. In a particular embodiment, the ratio of miRNA-21 to miRNA-221 can be used to diagnosis the presence of lung cancer or to monitor the response of a lung cancer patient to treatment. | 2012-12-27 |
20120329061 | QUANTITATIVE RT-PCR DETECTION FOR GENES INVOLVED IN EPITHELIAL MESENCHYMAL TRANSITION IN PERIPHERAL BLOOD OF CANCER PATIENTS - An assay and associated methodologies for detection of breast cancer are described. Circulating tumor cells (“CTCs”) undergo epithelial mesenchymal transition (“EMT”) prior to entering circulation, resulting in the loss of epithelial markers. These CTCs and EMT-related gene transcripts in the peripheral blood of patients are tested by quantitative RT-PCR to detect and diagnose breast cancer. | 2012-12-27 |
20120329062 | Rapid, Sensitive and Quantitative Methods for Tissue and Cell-Based Proteomics Via Consecutive Additional Quantifiable Extenders - Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen binding agent attached to a DNA containing an RNA polymerase promoter. | 2012-12-27 |
20120329063 | NOVEL MEANS FOR THE DIAGNOSIS AND THERAPY OF CTCL - The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL. | 2012-12-27 |
20120329064 | ENRICHMENT OF NUCLEIC ACID TARGETS - Methods and apparatus providing improved fidelity and specificity when separating nucleic acids from a sample, but without need for amplification. In particular, using the disclosed methods, it is possible to isolate a variant nucleic acid (i.e., a mutation) from a non-target nucleic acid (i.e., a wild-type) when the variant is present in the original sample at a much lower concentration than the non-target, e.g., 1:10,000, without substantial loss of the variant. | 2012-12-27 |
20120329065 | USE OF NOVEL CYTOKINE RECEPTORS AS BIOMARKERS AND THERAPEUTIC TARGETS IN HUMAN CANCER - Nucleic acids encoding erythropoietin isoforms are described herein, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer. | 2012-12-27 |
20120329066 | FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING AND ATHEROSCLEROSIS - Although it can be farnesylated, mutant lamin A expressed in Hutchinson Gilford Progeria Syndrome cannot be defarnesylated; the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (“progerin”) that alters normal lamin A function as a dominant negative, and assumes its own aberrant function through its association with the nuclear membrane. Retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) will inhibit formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies. In addition, elements of atherosclerosis and aging in non-laminopathy individuals will improve after treatment with FTIs. | 2012-12-27 |
20120329067 | Methods of Generating Zinc Finger Nucleases Having Altered Activity - Provided herein are zinc linger nucleases having altered, arid in particular, improved catalytic activity and methods of generating such nucleases. Accordingly, there are provided methods for identifying improved catalytic activity of a ZFN by expressing a mutated zinc finger nuclease in a cell containing a reporter construct with a toxic gene, and a zinc finger nuclease cleavage site that is recognized by the ZFN. Survival of the cell is positively correlated with catalytic activity of the ZFN; thus, libraries of mutated ZFKs may be selected for altered catalytic activity based on relative survival rates, Methods of using identified ZFNs are also provided. | 2012-12-27 |
20120329068 | FLUORESCENT DYES, FLUORESCENT DYE KITS, AND METHODS OF PREPARING LABELED MOLECULES - The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners. | 2012-12-27 |
20120329069 | METHODS FOR ANTIBODY ENGINEERING - The invention provides a method for identifying positions of an antibody that can be modified without significantly reducing the binding activity of the antibody. In many embodiments, the method involves identifying a substitutable position in a parent antibody by comparing its amino acid sequence to the amino acid sequences of a number of related antibodies that each bind to the same antigen as the parent antibody. The amino acid at the substitutable position may be substituted for a different amino acid without significantly affecting the activity of the antibody. The subject methods may be employed to change the amino acid sequence of a CDR without significantly reducing the affinity of the antibody of the antibody, in humanization methods, or in other antibody engineering methods. The invention finds use in a variety of therapeutic, diagnostic and research applications. | 2012-12-27 |
20120329070 | BIOMARKER PANELS FOR ASSESSING RADIATION INJURY AND EXPOSURE - Methods and kits are provided for assessing radiation injury and exposure in a subject. The methods comprise measuring the levels of at least two (2) protein biomarkers from different biological pathways and correlating the levels with an assessment of radiation injury and exposure. Additional use of peripheral blood cell counts and serum enzyme biomarkers, evaluated in the early time frame after a suspected radiation exposure, and use of integrated multiple parameter triage tools to enhance radiation exposure discrimination and assessment are also provided. The information obtained from such methods can be used by a clinician to accurately assess the extent of radiation injury/exposure in the subject, and thus will provide a valuable tool for determining treatment protocols on a subject by subject basis. | 2012-12-27 |
20120329071 | PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR RENAL DISORDERS - The present invention relates to a method of diagnosing a renal disorder. The method includes the steps of: (1) obtaining a biological sample from a subject; and (2) determining, in the biological sample, a level of one or more proteins whose abundance in urine change due to the renal disorder, wherein an increase or decrease in the level of one or more of the proteins compared to a control level is indicative of a renal disorder. | 2012-12-27 |
20120329072 | Modification-Dependent Activity Assays - Disclosed herein are methods, systems and kits to measure the presence and/or activity of recombinant polypeptides comprising a modification. | 2012-12-27 |
20120329073 | METHOD OF DETECTING PORK IN PROCESSED FOOD AND DETECTION KIT THEREFOR - [Object] To provide preparation of an ingredient derived from a specimen optimal for detecting by immunoassay pork in heated food with high performance and high sensitivity without causing non-specific reaction, a convenient and high-accuracy detection method using a polyclonal antibody obtained by using the ingredient, and a detection kit therefor. | 2012-12-27 |
20120329074 | MARKER FOR DETECTING GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER - It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein. | 2012-12-27 |
20120329075 | MONITORING PROTEIN TRAFFICKING USING BETA-GALACTOSIDASE REPORTER FRAGMENT COMPLEMENTATON - Methods and materials are disclosed for use in an enzyme fragment complementation assay using complementary fragments of β-galactosidase to study the trafficking of proteins in a cell. Compounds that bind to a target peptide have been found to affect protein folding and therefore trafficking. β-Galactosidase fragments, an enzyme donor (ED) and an enzyme acceptor (EA), are fused to a target peptide and to an intracellular compartment protein, wherein the compartment is involved in intracellular trafficking. Contacting the cell with a compound that binds to the target peptide results in enhanced movement of the protein through the cellular trafficking pathway comprised of the endoplasmic reticulum, Golgi apparatus, the plasma membrane, endosomes, etc. Using this approach, compounds that bind to a target peptide and alter its ability to traffic through the normal cellular pathway can be readily detected. | 2012-12-27 |
20120329076 | Antibodies to Non-Functional Oligomeric P2X7 Receptors - The invention relates to purinergic receptors, to antibodies and related fragments thereof for binding to said receptors, to production of said antibodies and fragments and to use of said antibodies and fragments for cancer detection and therapy. In particular the antibodies described bind specifically to non-functional P2X7 receptors expressed by live cells. | 2012-12-27 |
20120329077 | METHODS AND COMPOSITIONS FOR CATEGORIZING PATIENTS - The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and amino acid sequences related to the molecular markers, reagents for detection of molecular markers, and methods for identifying candidate molecular markers in highly parallel gene expression data. | 2012-12-27 |
20120329078 | METHOD OF DIAGNOSING CANCER USING G-CSF PROTEIN HAVING A DELETION OF AN AMINO ACID SEQUENCE CORRESPONDING TO EXON 3 AS A DIAGNOSTIC CANCER MARKER - Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker. | 2012-12-27 |
20120329079 | Pro108 Antibody Compositions and Methods of Use and Use of Pro108 to Assess Cancer Risk - A method for assessing risk of prostate cancer utilizing both Pro108 and Prostate Specific Antigen (PSA) in combination is provided. Also provided is a method for assessing risk of cancer utilizing Pro108 or specific antibodies to Pro108. Antibodies that bind to Pro108 on a mammalian cell in vivo and compositions comprising an anti-Pro108 antibody and a carrier which can be provided in an article of manufacture or a kit are also provided. An isolated nucleic acid encoding an anti-Pro108 antibody, an expression vector comprising the isolated nucleic acid, cells that produce the anti-Pro108 antibodies and a method of producing the anti-Pro108 antibodies as well as methods for use of the antibodies in killing an Pro108-expressing cancer cell and alleviating or treating an Pro108-expressing cancer in a mammal are also provided. | 2012-12-27 |
20120329080 | ANTI-HLA ASSAY AND METHODS - Anti-MHC assay methodologies utilize functionally active, recombinantly produced, truncated individual soluble MHC trimolecular complexes that are linked to a substrate. | 2012-12-27 |
20120329081 | SAMPLING DEVICES AND METHODS OF USE - Sample-collecting devices, articles and methods of use are disclosed. Premoistened sample-collecting devices comprise 1,2-propanediol as a humectant, which promotes the retention of a liquid solution on the sample-collecting device during storage. 1,2-propanediol as humectant can be compatible with proteins and other reagents used to detect an analyte. | 2012-12-27 |
20120329082 | Devices, Systems and Methods For Evaluation of Hemostasis - Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies. | 2012-12-27 |
20120329083 | TEST UNIT CARTRIDGE FOR ANALYTE TESTING DEVICE - A test unit cartridge for holding a plurality of test units includes a first test unit that contains a first analyte sensor and a second test unit that contains a second analyte sensor. The first and second analyte sensors use first and second reagents to detect first and second analytes, respectively. The first analyte is different from the second analyte and the first and second test units are functionally non-fungible. The plurality of test units can also include a third test unit that contains two analyte sensors having two reagents for detecting two different analytes using one fluid sample. A method of using the test unit cartridge is also described, which comprises loading the cartridge into an analyte testing device and cocking an actuator of the device that is configured to (i) expose an analyte sensor of a test unit, (ii) ready a lancet, and (iii) advance a lancet cartridge. | 2012-12-27 |
20120329084 | HIGH THROUGHPUT SCREENING OF LACTIC ACID-PRODUCING MICROORGANISM - A high throughput screening system and method of a lactic acid-producing microorganism using a mixture of at least two pH indicators are provided. The method may be useful in determining a production amount of a lactic acid, which is a final metabolite secreted by the microorganism, more accurately, rapidly and easily. | 2012-12-27 |
20120329085 | FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES - The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. | 2012-12-27 |
20120329086 | CHEMO-SENSITIVITY ASSAYS USING TUMOR CELLS EXHIBITING PERSISTENT PHENOTYPIC CHARACTERISTICS - The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to detect phenotypic and genotypic drift and for predicting chemotherapeutic response of patient tumor cells to at least one therapeutic agent. The assays, methods, tools and systems discussed herein also represent an improved and unified system for monitoring and for screening multiple pharmaceutical agents for efficacy and long term effect as to a specific patient. | 2012-12-27 |
20120329087 | CELL PREPARATION CONTAINING MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME - A cell preparation containing mesenchymal stem cells whose immunosuppression ability is maintained is produced by means of a serum-free or low-serum culture. A method for producing a cell preparation containing mesenchymal stem cells, comprising the steps of: (A) proliferating mesenchymal stem cells in a serum-free medium “A” containing an FGF, a PDGF, a TGF-β, an HGF, an EGF, at least one phospholipid, and at least one fatty acid; and (B) screening mesenchymal stem cells whose immunosuppression ability is maintained or improved, from the mesenchymal stem cells thus proliferated in the step (A). | 2012-12-27 |
20120329088 | PROCESSING SYSTEM FOR PROCESSING SPECIMENS USING ACOUSTIC ENERGY - A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver. | 2012-12-27 |
20120329089 | METHODS OF GENERATING HYDROGEN - The present invention, in some embodiments thereof, relates to a photocatalytic method of generating hydrogen gas in algae, and, more particularly, but not exclusively, to algal-bacterial co-culture for enhancing the kinetics and improving the yield of algal hydrogen photoproduction. | 2012-12-27 |
20120329090 | Methods for Producing Heterologous Polypeptides in Thiol-Disulfide Oxidoreductase-Deficient Bacterial Mutant Cells - The present invention relates to methods of producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent bacterial cell in a medium for the production of the heterologous polypeptide, wherein (i) the mutant cell comprises a first polynucleotide encoding the heterologous polypeptide which comprises two or more (several) cysteines, and a second polynucleotide comprising a modification of a gene encoding a thiol-disulfide oxidoreductase that incorrectly catalyzes the formation of one or more (several) disulfide bonds between the two or more (several) cysteines of the heterologous polypeptide, and (ii) the mutant cell is deficient in production of the thiol-disulfide oxidoreductase compared to the parent bacterial cell when cultivated under the same conditions; and (b) recovering the heterologous polypeptide from the cultivation medium. The present invention also relates to such bacterial mutants and methods for producing such bacterial mutants. | 2012-12-27 |
20120329091 | RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS - Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide. | 2012-12-27 |
20120329092 | PROCESS FOR THE PURIFICATION OF GLYCOPROTEINS - The present invention relates to a process for the purification of a glycoprotein comprising subjecting a liquid containing said glycoprotein to the steps of:
| 2012-12-27 |
20120329093 | POLYNUCLEOTIDES ENCODING ANTIBODIES THAT BIND BOTH IL-17A AND IL-17F - The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation. | 2012-12-27 |
20120329094 | Anti-CD22 Antibodies And Immunoconjugates and Methods of Use - Anti-CD22 antibodies and immunoconjugates thereof are provided. Methods of using anti-CD22 antibodies and immunoconjugates thereof are provided. | 2012-12-27 |
20120329095 | METHOD OF PRODUCING SUCCINIC ACID - Provided is a method of producing succinic acid in which a microorganism having a succinic acid-producing ability is allowed to react with a sugar, the method being characterized in that the ratio of the oxygen transfer rate to the succinic acid production rate (mmol-O | 2012-12-27 |
20120329096 | RECOVERY OF INORGANIC SALT DURING PROCESSING OF LIGNOCELLULOSIC FEEDSTOCKS - A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base is then added to the pretreated lignocellulosic feedstock to adjust the pH and produce a neutralized feedstock. The neutralized feedstock is then enzymatically hydrolyzed to produce an enzyme hydrolyzed feedstock and a sugar stream. Inorganic salt is recovered from either a stream obtained from the lignocellulosic feedstock prior to the step of pretreating, a stream obtained from the pretreated lignocellulosic feedstock, a stream obtained from the neutralized feedstock, a stream obtained from the sugar stream, or a combination of these streams. The inorganic salt may be concentrated, clarified, recovered and purified by crystallization, electrodialysis drying, or agglomeration and granulation, and then used as desired, for example as a fertilizer. | 2012-12-27 |
20120329097 | NUCLEIC ACID AMPLIFICATION - The present invention provides improved methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products. | 2012-12-27 |
20120329098 | CELLOBIOSE 2-EPIMERASE, ITS PREPARATION AND USES - The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme. | 2012-12-27 |
20120329099 | Modified Algae for Improved Biofuel Productivity - Methods, processes, and systems for the production of lipids and starch from modified algae are disclosed. In one embodiment, the modified algae over-expresses isoamylase and accumulates much higher amounts of starch than unmodified algae. In some embodiments, the modified algae comprises one or more copies of an isoamylase expression construct. In one embodiment, the modified algae is a sta7 | 2012-12-27 |
20120329100 | LIGNIN-BASED ENZYME STABILIZER - The invention relates to an enzyme stabilizer comprising a lignin derivative produced by reaction between lignin and a hydrophilic compound, and to a method of saccharifying lignocellulosic biomass which employs the enzyme stabilizer. According to the invention it is possible to accomplish effective saccharification of cellulosic biomass with saccharifying enzymes, by enhancing saccharifying enzyme activity and preventing nonspecific adsorption of saccharifying enzyme onto substrate. | 2012-12-27 |
20120329101 | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 2012-12-27 |
20120329102 | BIOLOGICAL PRODUCTION OF PENTOSE SUGARS USING RECOMBINANT CELLS - The invention provides, inter alia, compositions and methods for the biological production of pentose sugars, such as 2-methylerythritol (2-ME), 1-deoxyxylulose (1-DX), and monoacetylated-2-C-methylerythritols, using recombinant cells. | 2012-12-27 |
20120329103 | PLANT WALL DEGRADATIVE COMPOUNDS AND SYSTEMS - The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications. | 2012-12-27 |
20120329104 | MODIFIED MICROORGANISM HAVING ENHANCED XYLOSE UTILIZATION - A modified microorganism having enhanced xylose utilization, an expression vector for constructing the modified microorganism, and a method of producing a chemical using the same are disclosed. | 2012-12-27 |
20120329105 | BACTERIUM OF ENTEROBACTERIACEAE FAMILY PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES AND A METHOD FOR PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES - The presently disclosed subject matter provides a bacterium of Enterobacteriaceae family producing L-aspartic acid or an L-aspartic acid-derived metabolite modified to have aspartate dehydrogenase and a method for producing L-aspartic acid or an L-aspartic acid-derived metabolite, such as L-threonine, L-lysine, L-arginine, L-methionine and L-homoserine, using such bacterium. | 2012-12-27 |
20120329106 | PROCESS FOR PRODUCTION OF L-AMINO ACID - Provided is a novel process for producing an L-amino acid using a microorganism belonging to the genus | 2012-12-27 |
20120329107 | METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACIDS AND OPTICALLY ACTIVE AMINO ACID AMIDES - The present invention relates to a method for producing D- or L-tert-leucine or D- or L-tert-leucine amide by reacting DL-tert-leucine amide with a biocatalyst selected from the group consisting of an enzyme capable of hydrolyzing the DL-tert-leucine amide stereoselectively, cells of a microorganism having the enzyme, a material produced by the treatment of the cells, an immobilized enzyme produced by immobilizing the enzyme onto a carrier, immobilized cells produced by immobilizing the cells onto a carrier, and an immobilized cell treatment product obtained by immobilizing the cell treatment product onto a carrier to thereby hydrolyze the DL-tert-leucine amide, wherein the hydrolysis is carried out with separating ammonia produced by the hydrolysis from the hydrolysis reaction solution. According to the present invention, the concentration of an amino acid amide as a raw material in the reaction solution can be enhanced without the need of increasing the amount of the cells or a pH-adjusting acid by maintaining the activity per unit amount of the enzyme, the cells or the cell treatment product and per unit time period at a high level in the enzymatic reaction for hydrolyzing an amino acid amide stereoselectively, and consequently the productivity of optically active tert-leucine or optically active tert-leucine amide can be improved to a great extent without increasing the generation of a waste salt or waste cells. | 2012-12-27 |
20120329108 | Transaminase Biocatalysts - The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides. | 2012-12-27 |
20120329109 | Genetically Engineered Microorganisms That Metabolize Xylose - The invention provides methods of cultivating oil-bearing microbes using xylose as a fixed carbon source. Also provided are microorganisms that have been genetically engineered to metabolize xylose as a fixed carbon source allowing them to convert xylose into oils. Particular advantages of the processes provided herein include production of oils rather than alcohols through the microbial fermentation processes utilizing xylose. | 2012-12-27 |
20120329110 | GENETIC MODIFICATION FOR PRODUCTION OF 3-HYDROXYPROPIONIC ACID - A method of increasing 3-HP production efficiency by inhibiting expression of a lactate dehydrogenase, a phosphotransacetylase, and an alcohol dehydrogenase in production of 3-HP using a malonic semialdehyde reduction pathway to prevent metabolite leak and increase a malonyl-CoA pool is disclosed. | 2012-12-27 |
20120329111 | Microorganisms for Producing Cyclohexanone and Methods Related Thereto - Provided herein is a non-naturally occurring microbial organism having a cyclohexanone pathway and comprising at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. Also provided herein is a method for producing cyclohexanone, including culturing these non-naturally occurring microbial organisms. | 2012-12-27 |
20120329112 | Microorganisms Having Enhanced Tolerance To Inhibitors and Stress - The present invention provides genetically modified strains of microorganisms that display enhanced tolerance to stress and/or inhibitors such as sodium acetate and vanillin. The enhanced tolerance can be achieved by increasing the expression of a protein of the Sm-like superfamily such as a bacterial Hfq protein and a fungal Sm or Lsm protein. Further, the present invention provides methods of producing alcohol from biomass materials by using the genetically modified microorganisms of the present invention. | 2012-12-27 |
20120329113 | Microorganisms for Producing 1,3-Butanediol and Methods Related Thereto - Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. In some embodiments, the pathway includes reducing equivalents from CO or hydrogen. In certain embodiments, a 1,3-BDO pathway proceeds by way of central metabolites pyruvate, succinate or alpha-ketoglutarate. Also provided herein is a method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO. | 2012-12-27 |
20120329114 | XYLOSE UTILIZING ZYMOMONAS MOBILIS WITH IMPROVED ETHANOL PRODUCTION IN BIOMASS HYDROLYSATE MEDIUM - Xylose-utilizing, ethanol producing strains of | 2012-12-27 |
20120329115 | CHROMOSOMAL DNA INTEGRATION METHOD - The present disclosure relates to methods of integrating recombinant polynucleotides into genomes of unicellular organisms. In particular, the present disclosure relates to the modified unicellular organisms that contain integrated recombinant polynucleotides in their genomes and methods for production of commodity chemicals by the use of such organisms. | 2012-12-27 |
20120329116 | PRETREATMENT OF LIGNOCELLULOSIC BIOMASS THROUGH REMOVAL OF INHIBITORY COMPOUNDS - A process for the pretreatment of lignocellulosic biomass is disclosed, which includes the steps of pretreating the lignocellulosic biomass to hydrolyze and solubilize hemicelluloses in the biomass; explosively decomposing the biomass into fibers; and extracting from the resulting solids fraction a liquefied portion of the lignocellulosic biomass before or after explosive decomposition. This removes compounds from the lignocellulosic biomass which are inhibitory to enzymatic cellulose hydrolysis and sugar fermentation to ethanol. For improved economy, the inhibitory compounds are not completely removed. The extraction step is controlled on the basis of the xylose equivalent content in the reaction mixture and the extracting step is discontinued once a xylose equivalent content of 4-8% w/w of xylose in the dry matter of the solids fraction is achieved. This most economically balances the practical need for inhibitory compound removal with the economical need to minimize the costs of the overall ethanol production process. | 2012-12-27 |
20120329117 | CONTROL OF CONTAMINANT MICROORGANISMS IN FERMENTATION PROCESSES WITH SYNERGISTIC FORMULATIONS CONTAINING STABILIZED CHLORINE DIOXIDE AND PEROXIDE COMPOUND - A method for controlling growth of contaminant microorganisms in a fermentation process using a combination of (a) stabilized chlorine dioxide (SCD) and (b) a peroxide compound (PC). The method comprises adding SCD and PC to one or more steps of a fermentation process. In this method, the SCD and PC may be added to one or more components of a fermentation broth comprising inoculant, fermentable sugar and process water. | 2012-12-27 |