52nd week of 2011 patent applcation highlights part 51 |
Patent application number | Title | Published |
20110319584 | ADAMANTANE DERIVATIVE, METHOD FOR PRODUCING SAME, POLYMER USING SAME AS STARTING MATERIAL, AND RESIN COMPOSITION - Provided are an adamantane derivative represented by the following formula (1), a method for producing the same, a polymer containing an acrylate compound having the adamantane structure represented by formula (1) in a repeat unit, and a functional resin composition which contains the polymer, has excellent alkali developability and substrate adhesiveness, and can improve the resolution and the line edge roughness as a chemically amplified resist sensitive to far-ultraviolet rays represented by KrF excimer laser light, ArF excimer laser light, F | 2011-12-29 |
20110319585 | METHOD FOR PRODUCING ULTRAHIGH MOLECULAR WEIGHT POLYETHYLENE FILM - Disclosed is a method for producing a ultra high molecular weight polyethylene film, which comprises: a step of forming a film using a ultra high molecular weight polyethylene material; a step of biaxially drawing the film obtained in the step in the x-axis direction and in the y-axis direction at a temperature not less than the melting point of the ultra high molecular weight polyethylene material; and the step of shrinking the film along at least one of the x-axis direction and y-axis direction. By this method, a ultra high molecular weight polyethylene film having high tensile strength at break, high tear strength and excellent uniformity can be efficiently produced at low cost. | 2011-12-29 |
20110319586 | Ketal Compounds from Polyols and Oxocarboxylates - Novel ketal compounds can be made from an oxocarboxylate and a triol. Novel polymeric structures are, in turn, synthesized from the ketal compounds. Such ketal compounds and associated polymers are useful in a broad range of applications as a substitute for materials derived from petroleum or other such nonrenewable resources. | 2011-12-29 |
20110319587 | METHOD FOR MANUFACTURING POLYARYLENE SULFIDE RESIN - A method for producing a polyarylene sulfide resin includes allowing a polyhaloaromatic compound (a), an alkali metal hydrosulfide (b), and an organic acid alkali metal salt (c) to react with each other in the presence of a solid alkali metal sulfide and an aprotic polar organic solvent, wherein the reaction is conducted using the organic acid alkali metal salt (c) in a ratio of 0.01 moles or more and less than 0.9 moles relative to a total of 1 mole of the solid alkali metal sulfide and the alkali metal hydrosulfide (b) in a state where the amount of water existing in the reaction system is 0.02 moles or less relative to 1 mole of the aprotic polar organic solvent. Thus, it is possible to provide a method for producing a polyarylene sulfide resin with which high productivity is achieved on an industrial scale, and the molecular weight of the resulting polyarylene sulfide resin can be significantly increased. | 2011-12-29 |
20110319588 | ISOTACTIC POLYLACTIC ACID AND METHOD FOR PRODUCING SAME - Method of polymerization for producing polylactic acid of configuration L or D, with number-average molecular weight between 60 000 and 200 000 having an insertion defect rate between 0 and 0.5 wt. % of polylactic acid and a racemization defect rate between 0 and 2.5 wt. % of polylactic acid, characterized in that the method is a bulk process comprising contacting, at a temperature between 170 and 200° C. and for a reaction time between 5 and 75 minutes, the corresponding lactide of stereochemical configuration L-L or D-D having an optical purity of L or D of at least 99.5 wt. % with at least one catalyst in the presence of an initiator to form poly-L-lactic acid or poly-D-lactic acid. | 2011-12-29 |
20110319589 | LONG CHAIN ALKYLENE GROUP-CONTAINING EPOXY COMPOUND - It is an object to provide a liquid thermosetting composition that yields an epoxy resin having physical properties of the cured product such as high flexural strength along with adequate handleability as liquid, to be used in transparent sealants for optical semiconductors, such as transparent sealants for LEDs (light-emitting devices) and the like. There is provided a thermosetting composition containing an epoxy compound that a side chain between a triazinetrione ring and an epoxy group substituted on the triazinetrione ring is long (elongated). | 2011-12-29 |
20110319590 | Tumour Cell Lines and Uses Thereof - The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b). Additionally, the present invention provides a lysate of the cell lines or a molecule or mixture of molecules obtained from these cell lines as well as dendritic cells loaded with said lysate, co-cultivated or fused with cells from the cell lines, or a molecule or mixture of molecules obtained from these cell lines of the present invention. Moreover compositions, preferably pharmaceutical or vaccine compositions are provided which comprise the cell lines, lysate, molecules, mixture of molecules or dendritic cells of the present invention. In another aspect the present invention relates to methods for producing the aforementioned compositions. Furthermore, methods and uses for vaccination against or treatment or prevention of cancers and/or tumourous diseases are provided. | 2011-12-29 |
20110319591 | PEGYLATED, EXTENDED INSULINS - PEGylated, extended insulins are insulins which, compared with human insulin, has one or more extensions extended from the A1, B1, A21 and/or B30 position(s), said extension(s) consist(s) of amino acid residue(s) and wherein a PEG moiety, via a linker, is attached to one or more of the amino acid residues in the extension(s). PEG is polyethyleneglycol. Such PEGylated, extended insulins have higher bioavailability and a longer time-action profile than regular insulin and are in particular suited for pulmonary administration and can, conveniently, be used to treat diabetes. | 2011-12-29 |
20110319592 | Process for the Purification of Antibodies Using Affinity Resins Comprising Specific Ligands - The present invention relates to a novel process for the purification of antibodies, e.g. monoclonal antibodies. The process utilizes an affinity resin comprising a solid phase material having immobilized thereto one or more low-molecular weight synthetic ligands. The affinity resins enable the separation of antibodies from even closely related proteins. | 2011-12-29 |
20110319593 | PROCESS FOR THE PRODUCTION OF BIOLOGICALLY ACTIVE HIV-1 TAT PROTEIN - Tat protein produced in bulk culture is inactive when induced at conventional optical densities but can be obtained in biologically active form when induced during the logarithmic growth phase. | 2011-12-29 |
20110319594 | METHOD FOR PRODUCING BIVALIRUDIN - A method for producing bivalirudin using solid phase peptide synthesis by: a) condensing Fmoc-Asn(Trt)-Gly-OH with a peptide resin of Asp(OtBu) | 2011-12-29 |
20110319595 | FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF - The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described. | 2011-12-29 |
20110319596 | HYBRID VEGETABLE PROTEIN AND METHOD FOR OBTAINING SAME - A hybrid vegetable protein is described, comprising a guest protein having the structure of prolamine and glutelin, and a host protein having the structure of globulin and albumin, obtained from vegetable grains, such as corn and soybean, respectively. Likewise, a method for obtaining said hybrid vegetable protein is described, which comprises the steps of extracting the guest and host proteins, carrying out an acidification thereof, and further applying a magnetic field to provoke their attachment, and finally adding an alkali to the attached proteins to obtain a hybrid vegetable protein at its isoelectric point. The protein thus produced has a value higher than 0.97 according to the PDCAAS rating. | 2011-12-29 |
20110319597 | VARIANT DOMAIN ANTIBODIES - The present invention relates to domain antibodies which have modified framework regions such that the potency or level of binding of the domain antibody is improved. In particular the present invention relates to domain antibodies which bind TNFa in which changes have been made to framework sequences and to constructs including these domain antibodies. | 2011-12-29 |
20110319598 | METHODS AND MATERIALS FOR DETERMINING ISOELECTRIC POINT - The present disclosure relates to methods and materials for determining an isoelectric point for a protein including, for example, a binding molecule such as an antibody. The isoelectric points may be used in methods for the preparation of proteins. Such methods may comprise identifying amino acid residues that are exposed on the surface of the protein in a sequence of amino acid residues of the protein, assigning a pKa value to the surface exposed amino acid residues, and calculating the isoelectric point of the protein from the pKa values assigned to the surface exposed amino acid residues. The methods of the present disclosure may be used for selecting and utilizing a buffer for purification of a protein, preparing a protein formulation, purifying a protein and/or stabilizing a protein in solution. | 2011-12-29 |
20110319599 | MN Gene and Protein - A new gene —MN— and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and recombinant proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity, and the invention concerns methods and compositions for detecting and/or quantitating MN antigen and/or MN-specific antibodies in vertebrate samples that are diagnostic/prognostic for neoplastic and pre-neoplastic disease. MN-specific antibodies are disclosed that can be used diagnostically/prognostically, therapeutically, for imaging, and/or for affinity purification of MN proteins/polypeptides. The invention still further concerns antisense nucleic acid sequences that can be used to inhibit MN gene expression. | 2011-12-29 |
20110319600 | Human Anti-Human Influenza Virus Antibody - Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human influenza A virus subtype H3N2 or a human influenza B virus and has a neutralization activity against the virus. The human antibody is a human anti-human influenza virus antibody, which has a neutralization activity against a human influenza A virus subtype H3N2 and binds to a hemagglutinin HA1 region of the human influenza A virus subtype H3N2, or which has a neutralization activity against a human influenza B virus, and includes, as a base sequence of a DNA encoding a variable region of the antibody, a sequence set forth in any one of SEQ ID NOS: 5 to 12. | 2011-12-29 |
20110319601 | Inorganic Particle Conjugates - The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets. | 2011-12-29 |
20110319602 | T2R TASTE RECEPTORS AND GENES ENCODING SAME - Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers such as cAMP, cGMP, current e.g., by use of voltage-clamp or patch-clamp, techniques, fluorescence polarization or FRET assays, and the like. These assays are useful in identifying compounds that putatively elicit or modulate (inhibit or enhance) bitter taste in human subjects, e.g. bitter taste blockers. The effect of identified compounds on taste may be further evaluated in human or animal taste tests. | 2011-12-29 |
20110319603 | METHOD FOR FLUORESCENTLY LABELING PROTEIN - A method for fluorescently labeling a protein is provided that can also be used for labeling a biomolecule (a protein) in vivo with fluorescence. The method for fluorescently labeling a protein includes obtaining a fusion protein of a target protein to be labeled and, for example, a photoactive yellow protein (PYP), and fluorescently labeling the target protein by reacting the fusion protein with a compound represented by Formula (I), wherein in the compound represented by Formula (I), a coumarin skeleton in Formula (A) or a benzene skeleton in Formula (B) is intramolecnlarly associated with a group X and as a result, fluorescence derived from the group X is suppressed and when in the compound of Formula (I), the coumarin skeleton in Formula (A) or the benzene skeleton in Formula (B) is bound to the PYP or the PYP-derived protein contained in the fusion protein, the coumarin skeleton in Formula (A) or the benzene skeleton in Formula (B) is intramolecnlarly dissociated from the group X, and thereby fluorescence derived from the group X can be emitted. | 2011-12-29 |
20110319604 | METHOD FOR PREPARING METAL-ORGANIC FRAMEWORK CRYSTALLISED AND POROUS ALUMINIUM AROMATIC AZOCARBOXYLATES - The present invention relates to a method for preparing an MOF solid of a crystallised and porous aluminium aromatic azocarboxylate, in a non-aqueous organic medium. The invention also relates to solids made up of metal-organic frameworks (MOF) of aluminium aromatic azocarboxylates capable of being obtained by the method of the invention, as well as to the uses thereof for the storage of liquid or gaseous molecules, for selective separation of gas and for catalysis. | 2011-12-29 |
20110319605 | PURIFICATION OF A TRIPLE HELIX FORMATION WITH AN IMMOBILIZED OLIGONUCLEOTIDE - Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix. | 2011-12-29 |
20110319606 | COMPOUNDS AND METHODS FOR LABELING OLIGONUCLEOTIDES - A compound having the general formula shown below: | 2011-12-29 |
20110319607 | Method For The Microbial Production Of A Body Containing Cellulose - The invention relates to a method for producing a body ( | 2011-12-29 |
20110319608 | PROCESS FOR PREPARING A MIXED SALT OF GLUCOSAMINE SULFATE AND AN ALKALI METAL CHLORIDE - The present invention relates to a process for preparing a mixed salt of glucosamine sulfate and an alkali metal chloride. The process comprises the consecutive steps of:
| 2011-12-29 |
20110319609 | BETA-1,3-GLUCAN MANUFACTURING METHOD - A method for manufacturing a linear-chain beta-1,3-glucan is disclosed that comprises polymerizing glucose-1-phosphate serving as a substrate by contacting the glucose-1-phosphate with a beta-1,3-glucan phosphorylase derived from a species in the genus | 2011-12-29 |
20110319610 | DIAZEPINEDIONE DERIVATIVE - A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X | 2011-12-29 |
20110319611 | BENZOXAZINONE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME - A benzoxazinone compound having the following formula (I): | 2011-12-29 |
20110319612 | ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS - Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor. | 2011-12-29 |
20110319613 | Prodrugs of 2,4-Pyrimidinediamine Compounds and Their Uses - The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications. | 2011-12-29 |
20110319614 | Organic Compounds - The present invention relates to novel IAP inhibitor compounds of formula I: | 2011-12-29 |
20110319615 | INSECTICIDAL PYRIMIDINYL ARYL HYRDRAZONES - Pyrimidinyl aryl hydrazones are effective at controlling insects. | 2011-12-29 |
20110319616 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME - An object is to provide a thiazole derivative produced from easily available raw materials by a simplified production process. Provided are a process for producing a novel thiazole derivative represented by the general formula (I), which is characterized by adding a strong base to a thioamide represented by the general formula (II) and reacting the mixture with a thioformamide represented by the general formula (III), and a novel thiazole derivative. | 2011-12-29 |
20110319617 | Rosuvastatin and Atorvastatin Derivatives - This invention relates to the discovery of novel rosuvastatin and atorvastatin analogues. | 2011-12-29 |
20110319618 | HETEROCYCLIC COMPOUND AND USE OF THE SAME - Provided is a compound represented by general formula (6) and pharmaceutically acceptable salts thereof. (In the formula, R | 2011-12-29 |
20110319619 | NOVEL 1,6-DISUBSTITUTED-3-AMINO-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRID- IN-7-ONE COMPOUNDS AND PREPARATION THEREOF - Provided are a novel 1,6-disubstituted-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one compound, a pharmaceutically acceptable salt compound thereof, a method for preparing the compound, and an anticancer pharmaceutical composition including the compound as an effective ingredient. | 2011-12-29 |
20110319620 | METHOD FOR PRODUCING CARBOXYLIC ANHYDRIDE AND ARYLBORONIC ACID COMPOUND - When phthalic acid is heated in heptane under azeotropic reflux conditions in the presence of a catalytic amount of an arylboronic acid compound (such as 2,6-(diisopropylaminomethyl)phenylboronic acid or 2,6-bis(diisopropylaminomethyl)phenylboronic acid), phthalic anhydride is obtained in high yield. | 2011-12-29 |
20110319621 | METHOD FOR THE PREPARATION OF SOLIFENACIN AND INTERMEDIATE THEREOF - A method for the preparation of solifenacin by reacting quinuclidin-3-ol and bis(aryl) carbonate to form (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa); and treating (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa) with (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline of formula (V) in an inert atmosphere to form a Solifenacin base, which is converted into its pharmaceutically acceptable salts. The invention also provides a compound, (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa), which is used as an intermediate for the preparation of Solifenacin base and a process for the preparation thereof. | 2011-12-29 |
20110319622 | PROCESS OF PRODUCING BLEACH BOOSTERS - This invention relates to a process of producing compounds, which are useful as bleach boosters, as well as to the compounds, which are obtainable using said process, and to their use. | 2011-12-29 |
20110319623 | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-- BETA-PHENYL-3-QUINOLINEETHANOL - The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol by optical resolution with chiral 4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent. | 2011-12-29 |
20110319624 | CRYSTAL FORM OF QUINOLINE COMPOUND AND PROCESS FOR ITS PRODUCTION - A method for producing a drug substance of crystalline pitavastatin calcium excellent in stability, is presented. In the production of a compound (pitavastatin calcium) represented by the formula (1): | 2011-12-29 |
20110319625 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS - This invention provides compounds of formula I: | 2011-12-29 |
20110319626 | Use of Atorvastatin Lactols as Medicaments - This invention relates to the discovery of novel atorvastatin analogues. More specifically, the invention relates to novel atorvastatin analogues which have utility in treating conditions treatable by the inhibition of HMG-CoA reductase. | 2011-12-29 |
20110319627 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS - Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising substantially pure betrixaban free base or salt thereof. | 2011-12-29 |
20110319628 | ONE-POT PROCESS FOR THE SYNTHESIS OF DALFAMPRIDINE - A process for the preparation of Dalfampridine (1), 4-aminopyridine, starting from 4-pyridinecarbonitrile using a one-pot procedure. | 2011-12-29 |
20110319629 | TITANIUM COMPOUNDS AND PROCESS FOR CYANATION OF IMINES - The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R | 2011-12-29 |
20110319630 | POROUS REACTIVE FRAMEWORK - This disclosure relates to porous frameworks for gas separation, sensing and drug/biomolecule delivery. More particularly, the disclosure relates to reactive porous frameworks for functionalization. | 2011-12-29 |
20110319631 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS - Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ib-1: | 2011-12-29 |
20110319632 | PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS - Provided are compounds having Formula VIIIa-1: | 2011-12-29 |
20110319633 | FOAMED IONIC COMPOUNDS - Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications. | 2011-12-29 |
20110319634 | ALUMINUM COMPLEXES AND THEIR USE IN THE SYNTHESIS OF CYCLIC CARBONATES - Dimeric aluminium catalysts of formula I: and their use in catalysing the synthesis of cyclic carbonates from epoxides and carbon dioxide. | 2011-12-29 |
20110319635 | Process For Preparing N-Substituted Cyclic Imides - In a process for making an N-substituted phthalimide compound, an amine is contacted with a carboxylic acid anhydride and allowed to react in an aqueous solution at a pH of about 2 to about 6. Optionally, the reactants are combined with an acid to lower the pH of the reaction solution wherein the lowering of the pH optimizes the yield of the desired N-substituted phthalimide product. The N-substituted phthalimide may be, for example, N-hydroxyphthalimide, and the reactants may be phthalic anhydride and hydroxylamine or a salt thereof. The N-substituted phthalimide compound is useful for, among other things, the oxidation of various hydrocarbons. | 2011-12-29 |
20110319636 | METHOD FOR PREPARATION OF AMIDES FROM ALCOHOLS AND AMINES BY EXTRUSION OF HYDROGEN - The present invention relates to a method for preparation of carboxamides using alcohols and amines as starting materials in a dehydrogenative coupling reaction catalyzed by a ruthenium N-heterocyciic carbene (NHC) complex, which may be prepared in situ. | 2011-12-29 |
20110319637 | 2-FLUORO-1,3-BENZODITHIOL 1,1,3,3-TETRAOXIDE DERIVATIVE, PRODUCTION METHOD THEREOF, AND PRODUCTION METHOD OF MONOFLUOROMETHYL GROUP-CONTAINING COMPOUND USING THE SAME - A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R | 2011-12-29 |
20110319638 | ALUMINIUM COMPLEXES AND USE THEREOF AS A CATALYST IN INTRAMOLECULAR RING CLOSURE REACTIONS - To provide a process for increasing the proportion of an optical isomer of not only a compound having a closed ring but also a compound not having a closed ring when an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule is subjected to a ring closing reaction. A process for increasing the proportion of an optical isomer characterized by subjecting an optical isomer mixture of a compound having both a formyl group and a double bond capable of causing a carbonyl-ene ring closing reaction in the same molecule to a ring closing reaction in the presence of a predetermined aluminum complex represented by the general formula: [Al | 2011-12-29 |
20110319639 | Fluorescent Dye and Use Thereof - The invention relates to a fluorescent dye of general formula I or II | 2011-12-29 |
20110319640 | LARGE-SCALE PURIFICATION OF 2-PYRONE-4,6-DICARBOXYLIC ACID - To provide an industrial purification method of PDC obtained by fermentative production. | 2011-12-29 |
20110319641 | TREPROSTINIL PRODUCTION - The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil. | 2011-12-29 |
20110319642 | PROCESS FOR PRODUCING (.+-.)-3a,6,6,9a-TETRAMETHYL DODECAHYDRONAPHTHO[2,1-b]FURANS - The present invention relates to a process for producing (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans from crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans obtained by subjecting (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furan-2(1H)-ones which are produced by cyclizing a homofarnesylic acid amide or a monocyclohomofarnesylic acid amide in the presence of an acid agent and then hydrolyzing the cyclized product, to reduction reaction and then to cyclization reaction, said process including (i) an alkali treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans are heated in the presence of an alcohol and a metal hydroxide; and (ii) a washing treatment step in which the crude (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans are washed with an aqueous acid solution. The thus obtained (±)-3a,6,6,9a-tetramethyl dodecahydronaphtho[2,1-b]furans have a less off-odor and hardly suffer from deterioration of their smell during storage. | 2011-12-29 |
20110319643 | Synthesis of an Azido Energetic Alcohol - A method of forming an azido energetic alcohol includes converting an energetic diol to a cyclic sulfite, oxidizing the cyclic sulfite to a cyclic sulfate, and opening the cyclic sulfate. The cyclic sulfate is opened, followed by hydrolysis, to form an azido energetic alcohol. | 2011-12-29 |
20110319644 | PROCESS FOR PRODUCTION OF 1-HYDROXY-19-NORCYCLOVITAMIN D DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION - A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production. | 2011-12-29 |
20110319645 | ORGANOMETALLIC CATALYST AND PREPARATION THEREOF - The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxylic acid or anhydride and a metal-oxide, metal-hydroxide or metal-salt with a solvent at a temperature and pressure at which the solvent exists as a supercritical or near-critical fluid. The polycarboxylic acid or anhydride is reacted with the metal-oxide, metal-hydroxide or metal-salt for sufficient time and under sufficient temperature and pressure to produce the organometallic catalyst. The present invention also relates to a process for making a poly(alkylene carbonate) in the presence of a catalytic amount of the organometallic catalyst produced by the method. | 2011-12-29 |
20110319646 | PREPARATION OF SULFIDOSILANES - A process for the preparation of a sulfidosilane comprising reacting an aqueous phase comprising a sulfide compound, which is a polysulfide of the formula M | 2011-12-29 |
20110319647 | METHOD OF PRODUCING SILICA PARTICLES - The invention provides a method of producing silica particles, the method including preparing an alkali catalyst solution containing an alkali catalyst in a solvent including an alcohol, at a concentration of from about 0.6 mol/L to about 0.85 mol/L; and supplying tetraalkoxysilane into the alkali catalyst solution, and concurrently supplying an alkali catalyst into the alkali catalyst solution at a rate of from about 0.1 mol to about 0.4 mol per mole of the total amount of supply of the tetraalkoxysilane supplied in one minute. | 2011-12-29 |
20110319648 | Isocyanates and Aromatic Hydroxy Compounds - An object of the present invention is to provide a process for producing isocyanates, which are industrially useful compounds, without using phosgene, and to provide a process for chemically recycling waste polycarbonate resin. The present invention discloses a process enabling isocyanate compounds to be produced without using phosgene as a raw material by subjecting a carbamic acid ester compound obtained by a reaction between an aromatic polycarbonate resin and an amine compound to a thermal decomposition reaction, while at the same time disclosing a process enabling chemical recycling of aromatic polycarbonate resin by recovering a divalent aromatic hydroxy compound forming aromatic polycarbonates. | 2011-12-29 |
20110319649 | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide - The invention relates to ((R)-1-Benzylcarbamoyl-2-hydroxy-ethyl)-carbamic acid tert-butyl ester (compound III) with an ee of greater than 90%. | 2011-12-29 |
20110319650 | METHOD FOR PRODUCING OPTICALLY ACTIVE 2-HYDROXY ESTER AND NOVEL INTERMEDIATE COMPOUND - Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a carboxylic acid anhydride, or a carboxylic acid anhydride and a carboxylic acid. In particular, in the case where the solvent contains a carboxylic acid anhydride, but does not contain a carboxylic acid, as the carboxylic acid anhydride, a carboxylic acid anhydride containing a tertiary or quaternary carbon atom in the a-position is used. On the other hand, in the case where the solvent contains a carboxylic acid anhydride and a carboxylic acid, as the carboxylic acid, a carboxylic acid containing a tertiary or quaternary carbon atom in the a-position is used. | 2011-12-29 |
20110319651 | METHOD FOR PRODUCING FATTY ACID ALKYL ESTER AND PRODUCTION SYSTEM THEREFOR - [Problem] There are provided a method for production of a fatty acid alkyl ester and a system therefor, in which a high yield of the fatty acid alkyl ester is achieved even without using any special equipment and separation of a fatty acid alkyl ester phase from a glycerin phase can be carried out within an extremely short period of time. | 2011-12-29 |
20110319652 | Processes for Production of 2-Bromo-2,2-Difluoroethanol and 2-(Alkylcarbonyloxy)-1, 1-Difluoroethanesulfonic Acid Salt - Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom. | 2011-12-29 |
20110319653 | Intermediate of Cilastatin and Preparation Method Thereof - Disclosed is a method for preparing 7-halo-2-oxoheptylate, an intermediate of cilastatin. The main steps are as follows: A. Addition reaction, in which 6-halo-hexanal is reacted with a cyanide to obtain 7-halo-α-hydroxyl-heptonitrile; B. Hydrolysis reaction, in which 7-halo-α-hydroxyl-heptonitrile is converted to 7-halo-α-hydroxyl-heptylic acid; C. Esterification reaction, in which 7-halo-α-hydroxyl-heptylic acid is converted to 7-halo-α-hydroxyl-heptylate; and D. Oxidation reaction, in which 7-halo-α-hydroxyl-heptylate is converted to 7-halo-2-oxoheptylate. 7-halo-α-hydroxyl-heptylic acid or ester thereof, which is a new intermediate for synthesizing 7-halo-2-oxoheptylate or cilastatin, and a method for synthesizing cilastatin are also disclosed. The methods of the invention are suitable for commercial production because of their simple process and mild reaction condition. | 2011-12-29 |
20110319654 | CARBONYLATION PROCESS FOR THE PRODUCTION OF METHYL ACETATE - A process for the production of methyl acetate by reacting dimethyl ether with carbon monoxide into a carbonylation reactor containing a mordenite catalyst in the presence of added methyl acetate and/or acetic acid. | 2011-12-29 |
20110319655 | CATALYST SUPPORT, PROCESS FOR ITS PREPARATION AND USE - An open-pore catalyst support comprising a material that comprises a natural sheet silicate and ZrO | 2011-12-29 |
20110319656 | PROCESS FOR SYNTHESIS OF TRITIATED AND DEUTERATED THIORPHAN AND ACETORPHAN - Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula i | 2011-12-29 |
20110319657 | Process for the Preparation of Formic Acid - Process for obtaining formic acid by thermal separation of a stream comprising formic acid and a tertiary amine (I), in which a liquid stream comprising formic acid and a tertiary amine (I) in a molar ratio of from 0.5 to 5 is produced by combining tertiary amine (I) and a formic acid source, from 10 to 100% by weight of the secondary components present therein are separated off and formic acid is removed by distillation in a distillation apparatus at a bottom temperature of from 100 to 300° C. and a pressure of from 30 to 3000 hPa abs from the liquid stream obtained, the bottom discharge from the distillation apparatus being separated into two liquid phases and the upper liquid phase being recycled to the formic acid source and the lower liquid phase being recycled for separating off the secondary components and/or to the distillation apparatus. | 2011-12-29 |
20110319658 | PROCESS FOR PREPARING FORMIC ACID BY REACTION OF CARBON DIOXIDE WITH HYDROGEN - A process for preparing formic acid by reaction of carbon dioxide ( | 2011-12-29 |
20110319659 | METHOD FOR PRODUCING METHIONINE - A method for producing methionine includes a hydrolyzing step of hydrolyzing 5-(β-methylmercaptoethyl)hydantoin, and a crystallizing step of crystallizing with carbon dioxide introduced into a reaction solution after hydrolysis, to obtain methionine. In the crystallizing step, as carbon dioxide introduced into the hydrolysis reaction solution, carbon dioxide that is separated in a carbon dioxide separation section from a reformed gas formed by steam reforming reaction in a steam reformation section and carbon dioxide that is separated in an exhaust gas separation section from a combustion exhaust gas generated by pure oxygen combustion in a hydrocarbon heating furnace and a reformation reaction heating furnace are used. | 2011-12-29 |
20110319660 | METHOD OF PURIFYING LACTIC ACID BY CRYSTALLIZATION - Method for purifying lactic acid by crystallisation in one or a plurality of steps, characterised in that crystals are formed from an impure aqueous lactic acid solution having a colour of >500 Hazen, at a concentration between 85 and 95% by controlling the lactic acid oligomer content expressed in terms of a relative monomer content greater than 80% and controlling the degree of supersaturation of the solution between 1 and 60% in order to obtain lactic acid crystals having a specific surface area by mass of <0.05 m | 2011-12-29 |
20110319661 | PROCESS FOR PRODUCING (METH) ACRYLIC ACID - A process for producing (meth)acrylic acid of the present invention comprises the steps in the following order: a crystallization step of supplying a cooling medium cooled by a heat source device to a crystallizer to obtain a (meth)acrylic acid crystal from a crude (meth)acrylic acid solution; an adjustment step of returning the cooling medium discharged from the crystallizer to the crystallizer without cooling; a sweating step of supplying a heating medium to the crystallizer to partially melt the (meth)acrylic acid crystal, thereby obtaining a melted liquid, and discharging the melted liquid from the crystallizer; and a melting step of supplying the heating medium to the crystallizer to melt the (meth)acrylic acid crystal, thereby obtaining purified (meth)acrylic acid. According to the present invention, purified (meth)acrylic acid with high purity can be obtained. | 2011-12-29 |
20110319662 | METHOD FOR PRODUCING PHOSGENE - A process for preparing phosgene by reaction of a feed stream ( | 2011-12-29 |
20110319663 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof - A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base. | 2011-12-29 |
20110319664 | METHOD FOR PREPARING ATOMOXETINE - The present invention provides an efficient method for preparing atomoxetine in high yield. (R)-methylhydroxylaminopropanol compound of formula (II) in the present invention is used as an intermediate without the need for resolution processes. | 2011-12-29 |
20110319665 | Process for Preparing Substituted 2-Nitrobiphenyls - The present invention relates to a process for preparing substituted 2-nitrobiphenyls and to specific 2-nitrobiphenyls. The invention further relates to a process for preparing 2-aminobiphenyls from such 2-nitrobiphenyls and to a process for preparing (het)arylamides of such 2-aminobiphenyls. | 2011-12-29 |
20110319666 | METHOD OF OBTAINING 3,3-DIPHENYLPROPYLAMINES - The invention relates to a method of obtaining 3,3-diphenylpropylamines (I), wherein R | 2011-12-29 |
20110319667 | REACTION PROCESS UTILIZING CRITICAL - In order to perform organic synthesis process through action with supercritical water and acid stably while suppressing a trouble caused by a by-product, a method and an apparatus are provided, including the following steps. Water is supplied to high-pressure pumps ( | 2011-12-29 |
20110319668 | NON-BARBOTAGE METHOD FOR OXIDATION OF HYDROCARBONS BY FORMING AND UTILIZING LIQUID PHASE THIN FILM - The purpose of the present invention is to provide an advantageous non-barbotage method for oxidation of hydrocarbons, that, when implemented in various embodiments thereof, provides significantly higher selectivity, a greater level of safety, lower capital costs, etc., than conventional oxidation processes utilizing the barbotage technique. The essence of the inventive non-barbotage oxidation process is ensuring that the oxidizing agent delivered to the process reactor undergoes continued contact only with exposed surfaces of the liquid phase of the hydrocarbons being oxidized configured as at least one of: formed liquid phase thin film(s), liquid phase continuous stream(s), and/or liquid phase globule (e.g., droplets, etc.) stream(s), preferably, with the surface area(s) of the exposed surface(s) being maximized to increase contact with an oxidizing agent being directed thereto, to ensure that the inventive oxidation reaction occurs at the border between liquid and gas phases, such that the oxidation reaction effectively occurs by way of contact of the oxidizing agent (e.g., oxygen) from the gas phase with exposed surface(s) of the liquid phase of the hydrocarbons being oxidized. The inventive non-barbotage oxidation process may be implemented in a single reactor, or in plural sequential reactors, and may be implemented both in a stand-alone configuration, and in combination with various conventional barbotage methods for oxidation of hydrocarbons. | 2011-12-29 |
20110319669 | BRANCHED SECONDARY ALCOHOL ALKOXYLATE SURFACTANTS AND PROCESS TO MAKE THEM - Provided are alkoxylates of the formula I: | 2011-12-29 |
20110319670 | CRYSTALLIZER AND METHOD FOR PRODUCING PHENOL-BPA ADDUCT CRYSTALS - Both a crystallizer and method for the evaporative production of phenol-BPA adduct crystals are provided that achieve more uniform crystal growth while suppressing undesired crystal nucleation. The crystallizer includes a cylindrical vessel; a draft tube concentrically disposed within the cylindrical vessel such that an annular space is defined between the vessel and tube; an impeller that circulates liquid in the vessel through the draft tube and the annular space, and a plurality of nozzles mounted around an inner wall of said cylindrical vessel that introduce an evaporative coolant into the vessel. Each of the nozzles includes a discharge end disposed between about 30% and 60% of a radial extent of the annular space, and is located below an upper end of the draft tube a distance of between about 50% to 150% of the diameter of the vessel. Such a nozzle arrangement provides a consistent and uniform concentration of coolant across the surface of the boiling zone that prevents or at least reduces unwanted crystal nucleation on the inner surfaces of the vessel and promotes uniform crystal growth by providing a consistent and uniform degree of supersaturation across the annular space within the boiling zone. | 2011-12-29 |
20110319671 | PROCESS FOR PRODUCING OPTICALLY ACTIVE ALIPHATIC FLUOROALCOHOL - The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor. | 2011-12-29 |
20110319672 | Conversion Of Sugar, Sugar Alcohol, Or Glycerol To Valuable Chemicals Using A Promoted Zirconium Oxide Supported Catalyst - A process for converting a sugar, sugar alcohol, or glycerol to a valuable chemical is described. The process may use a support comprising zirconium oxide promoted by a polyacid or promoter material. A catalytically active metal may be impregnated on the polyacid-promoted zirconium oxide support and the catalyst may then be introduced the sugar, sugar alcohol, or glycerol a source of hydrogen under reaction conditions. At least 40 wt % of the sugar, sugar alcohol or glycerol may be converted to a polyol and/or a shorter carbon-chain alcohol that may include at least one of propylene glycol, ethylene glycol, glycerin, methanol, ethanol, propanol and butandiols. Specific processes for converting glycerin having a selectivity for propylene glycol and for converting sorbitol with a selectivity for propylene glycol, ethylene glycol, and/or glycerin are also described. | 2011-12-29 |
20110319673 | ZEOLITE CONTAINING WASH COATS FOR ADSORBER HEAT EXCHANGERS AND TEMPERATURE CONTROLLED ADSORBERS - The present invention provides a process for applying a coating on a heat exchanger or a temperature controlled adsorber surface. This coating comprises a zeolite, an organic solvent, an organic siloxane resin that constitutes a binder and a plasticizing agent. | 2011-12-29 |
20110319674 | PROCESS FOR THE MANUFACTURE OF FLUORINATED OLEFINS - Provided are methods for producing fluorinated organic compounds, which preferably comprises converting at least one compound of formula (I) CH | 2011-12-29 |
20110319675 | Catalytic Gas Phase Fluorination of 1233xf to 1234yf - The present invention provides a process for preparing 1234yf, comprising: (i) contacting 1233xf with hydrogen fluoride HF in gas phase in the presence of a fluorination catalyst under conditions sufficient to produce a reaction mixture; (ii) separating the reaction mixture into a first stream comprising HCl, 1234yf and a second stream comprising HF, unreacted 1233xf and 245cb; (iii) recycling at least a part of the second stream at least in part back to step (i). The present invention also provides a process for preparing 1234yf, comprising: (i) contacting 1233xf with hydrogen fluoride HF in gas phase in the presence of a fluorination catalyst under conditions sufficient to produce a reaction mixture; (ii) separating the reaction mixture into HCl and a stream containing the fluorinated products; (iii) separating said stream containing the fluorinated products into a first stream comprising 1234yf and a second stream comprising HF, unreacted 1233xf and 245cb; (iv) recycling at least a part of the second stream at least in part back to step (i). | 2011-12-29 |
20110319676 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The object is to provide a process whereby it is possible to produce 2,3,3,3-tetrafluoropropene at a high conversion ratio constantly for a long period of time. | 2011-12-29 |
20110319677 | Process for Producing 2, 3, 3, 3-Tetrafluoropropene - The object is to provide a process for producing highly pure 2,3,3,3-tetrafluoropropene, whereby formation of 3,3,3-trifluoropropene is suppressed. | 2011-12-29 |
20110319678 | PROCESS FOR PRODUCING 1,1-DICHLORO-2,3,3,3-TETRAFLUOROPROPENE AND 2,3,3,3-TETRAFLUOROPROPENE - To provide a process to produce 1,1-dichloro-2,3,3,3-tetrafluoropropene (CFO-1214ya) simply and economically without requiring purification of 1,1-dichloro-2,2,3,3,3-pentafluoropropane (HCFC-225ca) from the raw material component obtained as a mixture of isomers, i.e. dichloropentafluoropropane (HCFC-225) including HCFC-225ca and at the same time to produce simply and economically 2,3,3,3-tetrafluoropropene (HFO-1234yf) from 1-chloro-2,3,3,3-tetrafluoropropane (HCFC-244eb). | 2011-12-29 |
20110319679 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The object is to provide a process whereby it is possible to produce 2,3,3,3-tetrafluoropropene at a high conversion ratio constantly for a long period of time. | 2011-12-29 |
20110319680 | PROCESS FOR PRODUCING 2, 3, 3, 3-TETRAFLUOROPROPENE - In the production of 2,3,3,3-tetrafluoropropene (HFO-1234yf), formation of HFC-254eb as an excessively reduced product is suppressed. | 2011-12-29 |
20110319681 | PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE - The object is to provide a process for producing highly pure 2,3,3,3-tetrafluoropropene, whereby formation of 3,3,3-trifluoropropene as a by-product is suppressed. | 2011-12-29 |
20110319682 | Gas Hydrate Inhibitor and Method of Inhibiting Gas Hydrate Formation - The present invention relates to an ionic liquid compound that inhibits a formation of a gas hydrate. The compound of the present invention changes an equilibrium temperature and pressure of a gas hydrate in small quantity into a lower temperature and/or a higher pressure, and simultaneously retards the formation of the gas hydrate under the same environment. Thus, the compound of the present invention is used in oil and natural gas industries to effectively inhibit or delay the formation of the gas hydrate under the condition having a low temperature and a high pressure. | 2011-12-29 |
20110319683 | BIORENEWABLE NAPHTHA COMPOSITION AND METHODS OF MAKING SAME - The present invention generally relates to a method for producing a naphtha product from a renewable feedstock. The method includes hydrotreating the renewable feedstock to produce a hydrotreating unit heavy fraction that includes n-paraffins, and hydrocracking the hydrotreating unit heavy fraction to produce a hydrocracking unit product that includes the naphtha product. The method also includes separating the naphtha fraction and optionally recycling the hydrocracking unit heavy fraction through the hydrocracking unit. The present invention also relates to a biorenewable naphtha product suitable for use as feed stock for steam crackers and catalytic reforming units, and for use as fuel, or fuel blend stock. | 2011-12-29 |