52nd week of 2016 patent applcation highlights part 24 |
Patent application number | Title | Published |
20160376564 | Nucleic Acids and Polypeptides for Utilizing Plant Biomass - The present invention relates to novel nucleic acids, novel groups of polypeptides encoded by the polynucleotides, novel compositions, and methods of using the same with lignin containing substrates. | 2016-12-29 |
20160376565 | KETOREDUCTASE POLYPEPTIDES - The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl (1,3-oxazolidin-3-yl))-1-(4-fluorophenyl) pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize the intermediate (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one in a process for making Ezetimibe. | 2016-12-29 |
20160376566 | Peroxygenase Variants - The present invention relates to peroxygenase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 2016-12-29 |
20160376567 | HERBICIDE-RESISTANT HYDROXYPHENYLPYRUVATE DIOXYGENASES - The present invention refers to method for producing a transgenic plant with increased herbicide tolerance or resistance as compared to a corresponding non-transformed wild type plant, comprising transforming a plant cell or a plant cell nucleus or a plant tissue with a nucleic acid molecule encoding a HPPD polypeptide, as well as to the nucleic acid, and plants with increased HPPD-inhibiting herbicide tolerance or resistance comprising the nucleic acid of the invention. | 2016-12-29 |
20160376568 | THIENOPYRROLE COMPOUNDS AND USES THEREOF - Thienopyrrole compounds that may inhibit | 2016-12-29 |
20160376569 | GLYCOSYLTRANSFERASE GLYCOSYLATING FLAVOKERMESIC ACID AND/OR KERMESIC ACID - An isolated glycosyltransferase (GT) polypeptide capable of: (I): conjugating glucose to flavokermesic acid (FK); and/or (II): conjugating glucose to kermesic acid (KA) and use of this GT to e.g. make Carminic acid. | 2016-12-29 |
20160376570 | O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof - The present disclosure relates to compositions and methods useful for the production of heterologous proteins with reduced O-mannosylation in filamentous fungal cells, such as | 2016-12-29 |
20160376571 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF - The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. | 2016-12-29 |
20160376572 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF - The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. | 2016-12-29 |
20160376573 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF - The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. | 2016-12-29 |
20160376574 | MODIFIED GRAM POSITIVE BACTERIA AND USES THEREOF - The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or | 2016-12-29 |
20160376575 | PEPTIDE CAPABLE OF SILICA DEPOSITION AND USE THEREOF - A peptide for synthesizing silica and use thereof are provided. The peptide for synthesizing silica can polymerize silica from a silica precursor in an aqueous solution having conditions of normal temperature, normal pressure and near-neutral weak base. The peptide for synthesizing silica can form a self-assembled structure during silica synthesis, and thus can be used as various biomaterials such as a silica-based protein immobilizer, a biosensor, and a drug delivery system. | 2016-12-29 |
20160376576 | FLAVOR-IMPROVING ENZYME COMPOSITION, METHOD FOR SUPPRESSING OCCURRENCE OF UNPLEASANT ODOR, AND METHOD FOR MANUFACTURING FOOD WITH REDUCED UNPLEASANT ODOR - A flavor-improving enzyme composition for reducing an unpleasant odor in a food or beverage is disclosed, the composition containing an enzyme exhibiting phospholipase A2 activity with lipase activity/phospholipase A2 activity of not more than 0.005, as an active ingredient. | 2016-12-29 |
20160376577 | FACTOR VII POLYPEPTIDES THAT ARE MODIFIED AND USES THEREOF - Nucleic acid encoding modified factor VII polypeptides, vectors and cells containing the nucleic acid, uses of the nucleic acids, methods of making the encoded polypeptides, and methods of treatment are provided. The encoded modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among the encoded modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. | 2016-12-29 |
20160376578 | SHORT-ACTING FACTOR VII POLYPEPTIDES - Short-acting Factor VII peptides are disclosed. A shortened half-life is desirable for treatment of acute bleeding and similar disorders. Modification of the sialylation and/or glycosylation of Factor VII and variants thereof produced peptides useful in treating conditions of acute bleeding. | 2016-12-29 |
20160376579 | NEW ENZYMES AND METHOD FOR PREPARING 4-HYDROXYL BENZYL ALCOHOL AND DERIVATIVES THEREOF - The present invention relates to a new enzyme able to produce 4-hydroxybenzyl alcohol from the amino acid tyrosine and the use thereof for producing 4-hydroxybenzyl alcohol. | 2016-12-29 |
20160376580 | Method of Producing 1,5-Pentadiamine Using Lysine Decarboxylase Mutant Having Improved Thermal Stability - The present invention provides methods for producing 1,5-pentamethylenediamine (“1,5-PD”) efficiently in a manner suitable for an actual production. Specifically, the present invention provides a method of producing 1,5-pentamethylenediamine including allowing a lysine decarboxylase mutant to act on L-lysine and/or a salt thereof, wherein said lysine decarboxylase mutant has an amino acid sequence selected from the group consisting of:
| 2016-12-29 |
20160376581 | METHOD FOR THE PURIFICATION OF TARGETED NUCLEIC ACIDS FROM BACKGROUND NUCLEIC ACIDS - The present invention relates generally to the field of nucleic acid purification. In particular, provided herein are micro particles and micro particle clusters for selective anion exchange of nucleic acids, and methods and kits useful for this purpose. | 2016-12-29 |
20160376582 | MICRO RNA ISOLATION FROM BIOLOGICAL FLUID - The present disclosure provides methods and kits for isolating miRNAs from biological fluids. | 2016-12-29 |
20160376583 | DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2016-12-29 |
20160376584 | METHOD AND APPARATUS FOR DUAL SOLID PHASE NUCLEIC ACID SYNTHESIS - Provided herein are methods and apparatuses for synthesizing nucleic acids having a predefined sequence through enzymatic elongation. In some embodiments, the methods and/or apparatuses comprise controlled manipulation of solid objects with respect to a solid substrate comprising an oligonucleotide template array. | 2016-12-29 |
20160376585 | OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION - The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides. | 2016-12-29 |
20160376586 | NUCLEIC ACID MOLECULE, EXPRESSION CASSETTE, EXPRESSION VECTOR, EUKARYOTIC HOST CELL, INDUCTION METHOD OF RNA INTERFERENCDE IN EUKARYOTIC HOST AND USE OF THE NUCLEIC ACID MOLECULE IN THERAPY OF DISEASES INDUCED BY EXPANSION OF TRINUCLEOTIDE GAG REPEATS - Subjects of the invention are: nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG-type repeats. Solution relates to the new concept of treating hereditary human neurological diseases caused by expansion of CAG-type trinucleotide repeats using RNA interference technology. | 2016-12-29 |
20160376587 | FUNCTIONALLY-MODIFIED OLIGONUCLEOTIDES AND SUBUNITS THEREOF - Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects. | 2016-12-29 |
20160376588 | MOLECULAR RE-ENGINEERING OF EXCITATION-INHIBITION BALANCE IN MEMORY CIRCUITS - Disclosed are memory-regulating agents and methods that target actin binding LIM protein family, member 3 (ABLIM3). Specifically, the disclosure provides methods of inhibiting Ablim3 using inhibitory nucleic acids that target the Ablim3 gene or mRNA to improve memory in subjects with memory dysfunction associated with Alzheimer's Disease (AD), normal aging, or posttraumatic stress disorder (PTSD). Further disclosed is a cell-based assay that can be used to screen for small molecule regulat ors of Ablim3 function. | 2016-12-29 |
20160376589 | micro-RNA INHIBITOR - The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two or more complementary sequences are linked via one or more linker residues. | 2016-12-29 |
20160376590 | Methods and Compositions For The Specific Inhibition of Gene Expression by Double-Stranded RNA - The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA (“dsRNA”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery. | 2016-12-29 |
20160376591 | iRNA AGENTS WITH BIOCLEAVABLE TETHERS - The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose that further includes a tether having one or more linking groups, in which at least one of the linking groups is a cleavable linking group. The tether in turn can be connected to a selected moiety, e.g., a ligand, e.g., a targeting or delivery moiety, or a moiety which alters a physical property. The cleavable linking group is one which is sufficiently stable outside the cell such that it allows targeting of a therapeutically beneficial amount of an iRNA agent (e.g., a single stranded or double stranded iRNA agent), coupled by way of the cleavable linking group to a targeting agent—to targets cells, but which upon entry into a target cell is cleaved to release the iRNA agent from the targeting agent. | 2016-12-29 |
20160376592 | Methods of Manipulating the Fate of Cells - A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding RNA species (cuR), (b) a modified cuR, or (c) a compound that modifies or affects cuR, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of RNA:RNA or RNA:DNA or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. The invention generates cell fate or cell maintenance in a subject, such as a human, so that an increase of desirable cells or a decrease in undesirable cells can be obtained in the subject. This feature can be applied to a therapeutic method of treating a condition in a subject. | 2016-12-29 |
20160376593 | CHEMICALLY MODIFIED POLYNUCLEOTIDES AND METHOD FOR PRODUCING CHEMICALLY MODIFIED POLYNUCLEOTIDES - The present invention relates to chemically-modified polynucleotides of formula (I): 5′-CONS-SEQ.ID.n-CONS-3′ (I) containing one or more modified pyrimidines and at least one inverted nucleotide repeat, and to the method for producing the same. | 2016-12-29 |
20160376594 | Modified L-Nucleic Acid - A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism. | 2016-12-29 |
20160376595 | PEPTIDE APTAMERS FOR MANIPULATING PROTEIN FUNCTION - Peptide aptamers and the methods to produce cassettes including the aptamers and manipulating them, are described. The peptide aptamer cassettes are useful to, e.g., inhibit protein function such as proteins necessary for the transformation of plants, or to replicate cells. | 2016-12-29 |
20160376596 | COMPOSITIONS AND METHODS FOR INDUCING AN ENHANCED IMMUNE RESPONSE USING POXVIRUS VECTORS - Provided herein are recombinant poxviruses comprising heterologous or native nucleic acids specifying excess double-stranded RNA (dsRNA) early in infection, which may further comprise heterologous nucleic acids encoding one or more costimulatory molecules, and/or heterologous nucleic acids encoding one or more infectious disease-associated antigens or tumor-associated antigens, as well as pharmaceutical compositions comprising such recombinant poxviruses and methods and uses thereof. The recombinant poxviruses provided herein enhance innate and adaptive immune activation in subjects compared to identical recombinant poxviruses lacking heterologous or native transcription units specifying excess early dsRNA. | 2016-12-29 |
20160376597 | METHOD OF TREATING INFLUENZA A - A method of treating Influenza A is disclosed. The method includes the step of administering a pharmaceutical composition including an oligonucleotide complementary to a corresponding segment of the nucleotide sequence of microRNA-1290 (miR-1290) (SEQ ID NO: 1) to a subject suffering from Influenza A, wherein at least one of the nucleotides in the oligonucleotide is Thymidine phosphate. | 2016-12-29 |
20160376598 | Polycomb-Associated Non-Coding RNAS - This invention relates to long non-coding RNAs (lncRNAs), libraries of those ncRNAs that bind chromatin modifiers, such as Polycomb Repressive Complex 2, inhibitory nucleic acids and methods and compositions for targeting lncRNAs. | 2016-12-29 |
20160376599 | RNAi Inhibition of Alpha-ENaC Expression - The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. | 2016-12-29 |
20160376600 | METHODS FOR ENHANCING MICROBIAL PRODUCTION OF SPECIFIC LENGTH FATTY ALCOHOLS IN THE PRESENCE OF METHANOL - The invention provides non-naturally occurring microbial organisms having a formaldehyde fixation pathway, a formate assimilation pathway, and/or a methanol metabolic pathway in combination with a fatty alcohol, fatty aldehyde, fatty acid or isopropanol pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length or isopropanol. The microbial organisms provided advantageously enhance the production of substrates and/or pathway intermediates for the production of chain length specific fatty alcohols, fatty aldehydes, fatty acids or isopropanol. In some aspects, the microbial organisms of the invention have select gene disruptions or enzyme attenuations that increase production of fatty alcohols, fatty aldehydes or fatty acids. The invention additionally provides methods of using the above microbial organisms to produce a fatty alcohol, a fatty aldehyde, a fatty acid or isopropanol. | 2016-12-29 |
20160376601 | Hybrid immunoglobulins with moving parts - Hybrid immunoglobulins containing moving parts are provided as well as related compositions and methods of use and methods of production. In addition, analogous genetic devices are provided as well as related compositions and methods of use and methods of production. | 2016-12-29 |
20160376602 | VECTORS FOR USE IN AN INDUCIBLE COEXPRESSION SYSTEM - The present invention provides expression vectors for use in an inducible coexpression system, capable of controlled induction of expression of each gene product. | 2016-12-29 |
20160376603 | METHOD OF TRANSFORMING CELLS - Use of an isolated | 2016-12-29 |
20160376604 | SYSTEM FOR AUTOMATED EXPLANT PREPARATION AND METHOD OF USE - A system and method for the automated or semi-automated preparation of explants for transformation and transgenic engineering. | 2016-12-29 |
20160376605 | WHEAT PLANTS HAVING INCREASED TOLERANCE TO IMIDAZOLINONE HERBICIDES - The present invention is directed to wheat plants and triticale plants having increased tolerance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants or triticale plants containing one or more | 2016-12-29 |
20160376606 | IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES - The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby. | 2016-12-29 |
20160376607 | NOVEL INSECTICIDAL PROTEINS AND METHODS OF USE - Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are isolated insecticidal proteins and nucleic acids. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity. | 2016-12-29 |
20160376608 | ADENO-ASSOCIATED VIRUS VECTORS FOR TREATMENT OF GLYCOGEN STORAGE DISEASE - The present disclosure describes improved adeno-associated virus (AAV) vectors for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia). Described are recombinant nucleic acid molecules, vectors and recombinant AAV that include a G6PC promoter/enhancer, a synthetic intron, a G6PC coding sequence (such as a wild-type or codon-optimized G6PC coding sequence), and stuffer nucleic acid sequence situated between the G6PC promoter/enhancer and the intron, as well as between the intron and the G6PC coding sequence. The recombinant AAVs disclosed herein exhibit highly efficient liver transduction and are capable of correcting metabolic abnormalities in an animal model of GSD-Ia. | 2016-12-29 |
20160376609 | IS-TARGETING SYSTEM FOR GENE INSERTION AND GENETIC ENGINEERING IN DEINOCOCCUS BACTERIA - The present invention relates to methods and compositions for chromosome integration of nucleic acids into | 2016-12-29 |
20160376610 | CELL CYCLE DEPENDENT GENOME REGULATION AND MODIFICATION - Fusion protein comprising a programmable DNA modification protein and a cell cycle regulated protein, and methods of using the fusion protein to modify chromosomal sequences and/or regulate gene expression in a cell cycle dependent manner. | 2016-12-29 |
20160376611 | METHOD FOR PRODUCING ETHANOL - A method for producing ethanol, which is a method for producing ethanol from a saccharide obtained from biomass, includes a step of adding an additive solution containing at least acetic acid, formic acid, furfural, and hydroxymethylfurfural to the saccharide to prepare a mixed solution containing the saccharide and the additive solution, and a step of adding a microorganism to the mixed solution to ferment the saccharide using the microorganism, thereby producing ethanol. | 2016-12-29 |
20160376612 | METHOD FOR PREPARING ETHANOL USING YEAST - A method for producing ethanol using yeast is provided. The method includes a boiling process of heating a fermentation raw material, a saccharification process of saccharifying the boiled fermentation raw material with a coenzyme added thereto, and a fermentation process of inputting a mixed strain culture fluid into the saccharified fermentation raw material and fermentating the resultant product, wherein the mixed strain culture fluid is a culture fluid acquired by cultivating two or more kinds of | 2016-12-29 |
20160376613 | Glycerol 3-Phosphate Dehydrogenase for Butanol Production - Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased K | 2016-12-29 |
20160376614 | MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO - The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine. | 2016-12-29 |
20160376615 | RECOMBINANT MICROORGANISMS AND USES THEREFOR - The invention provides recombinant microorganisms and methods for the production of acetone from gaseous substrates. For example, the recombinant microorganism may be modified to express an exogenous thiolase, an exogenous CoA transferase, and an exogenous decarboxylase. | 2016-12-29 |
20160376616 | TREATMENT METHOD OF SACCHARIDE SOLUTION, PRODUCTION METHOD OF TREATED SACCHARIDE SOLUTION, TREATED SACCHARIDE SOLUTION, PRODUCTION METHOD OF ORGANIC COMPOUND AND CULTURE METHOD OF MICROORGANISM - The invention relates to a method for treating a solution containing a saccharide comprising a heat treatment step of heating the saccharide solution at a temperature of 100° C. or higher and 180° C. or lower and a reduction step of reacting a reducing agent with the saccharide solution heated in the heat treatment step, a method for producing a treated saccharide solution using the treatment method, a treated saccharide solution obtained through treatment by the treatment method, a method for producing an organic compound comprising an organic-matter production step of obtaining an organic compound by causing a microorganism capable of producing organic matter to act on an organic raw material containing the treated saccharide solution and a method for culturing a microorganism using the treated saccharide solution as a carbon source. | 2016-12-29 |
20160376617 | MICROBIAL OILS WITH LOWERED POUR POINTS, DIELECTRIC FLUIDS PRODUCED THEREFROM, AND RELATED METHODS - Methods and compositions for the production of dielectric fluids from lipids produced by microorganisms are provided, including oil-bearing microorganisms and methods of low cost cultivation of such microorganisms. Microalgal cells containing exogenous genes encoding, for example, a sucrose transporter, a sucrose invertase, a fructokinase, a polysaccharide-degrading enzyme, a lipid pathway modification enzyme, a fatty acyl-ACP thioesterase, a desaturase, a fatty acyl-CoA/aldehyde reductase, and/or an acyl carrier protein are useful in manufacturing dielectric fluids. | 2016-12-29 |
20160376618 | PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES - The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer. | 2016-12-29 |
20160376619 | HYDROCARBONS & HEAVY METALS INDUCE BIO-CATALYST TO MODIFY DEVELOPMENT PROCESS IN SEEDS, SEEDLINGS, AND PLANTS - The present invention is directed to methods of modifying the plant development process comprising of exposing a seed, seedling, or plant to volatiles biosynthesized by one or more bacteria or enzymes. Specifically, the embodiment uses one or more bacteria selected from the plant growth promoting bacteria group consisting of | 2016-12-29 |
20160376620 | Compositions Comprising A Polypeptide Having Cellulolytic Enhancing Activity And A Heterocyclic Compound And Uses Thereof - The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions. | 2016-12-29 |
20160376621 | FED BATCH PROCESS FOR BIOCHEMICAL CONVERSION OF LIGNOCELLULOSIC BIOMASS TO ETHANOL - A method for optimization of a fed batch hydrolysis process wherein the hydrolysis time is minimized by controlling the feed addition volume and/or batch addition frequency of the prehydrolysate and optionally also the enzyme feed. The increase over time in hydrolysate consistency and volume and/or concentration of sugars released in the reactor, so that the enzymatic hydrolysis is controlled, significantly reduces the impact of cellulase feedback inhibition, especially for enzyme contents lower than 1%. The overall time to reach conversion of the total prehydrolysate feed is reduced significantly where the batch addition frequency is equal to one batch each time 70% to 90%, preferably 80%, conversion of the previous batch is reached in the reaction mixture. At an enzyme load of 0.3% in the reaction mixture, the optimum frequency each time 80% conversion was reached was found to be one batch every 80 to 105 minutes. | 2016-12-29 |
20160376622 | Cellulolytic enzyme compositions and uses thereof - The present invention relates to recombinant filamentous fungal host cells producing cellulolytic enzyme compositions and methods of producing and using the compositions. | 2016-12-29 |
20160376623 | FAGOPYRITOL SYNTHASE GENES AND USES THEREOF - The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described. The method includes providing a fagopyritol synthase, providing a substrate comprising a galactosyl donor and a galactosyl acceptor, and combining the fagopyritol synthase with the substrate under conditions effective produce a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor. | 2016-12-29 |
20160376624 | CELL CULTURE PROCESS - Polypeptides having target levels of C-terminal variants are described. | 2016-12-29 |
20160376625 | Whole-Cell System For Cytochrome P450 Monooxygenases Biocatalysis - The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains. | 2016-12-29 |
20160376626 | SENSOR, SENSOR SYSTEM, METHOD OF MANUFACTURING SENSOR, AND METHOD OF MEASURING CONCENTRATION OF TARGET SUBSTANCE - The present invention provides: a reagent composition having higher storage stability; a sensor involving the reagent composition; and others. According to the present invention, a specific heterocyclic compound is added to a reagent composition to improve the storage stability of the reagent composition and reduce the degree of fluctuation in current values in a sensor that utilizes reagent composition. | 2016-12-29 |
20160376627 | METHODS, APPARATUSES, AND SYSTEMS FOR ANALYZING MICROORGANISM STRAINS FROM COMPLEX HETEROGENEOUS COMMUNITIES, PREDICTING AND IDENTIFYING FUNCTIONAL RELATIONSHIPS AND INTERACTIONS THEREOF, AND SELECTING AND SYNTHESIZING MICROBIAL ENSEMBLES BASED THEREON - Methods, apparatuses, and systems for screening, analyzing and selecting microorganisms from complex heterogeneous communities, predicting and identifying functional relationships and interactions thereof, and synthesizing microbial ensembles based thereon are disclosed. Methods for identifying and determining the absolute cell count of microorganism types and strains, along with identifying the network relationships between active microorganisms and environmental parameters, are also disclosed. | 2016-12-29 |
20160376628 | METHOD FOR SCREENING ANTIMICROBIAL AGENT - A method for screening an antimicrobial agent which is capable of controlling microorganisms causing offensive odor in an air-conditioning system and a method for removing offensive odor in an air-conditioning system are provided. The method for screening an antimicrobial agent and the method for removing offensive odor in an air-conditioning system may be used for various purposes of industrial application. For example, they may be used to develop a novel antimicrobial agent capable of inhibiting the growth of the microorganisms or to develop an air freshener for removing offensive odor by elucidating the chemical properties of the metabolites of the microorganisms. In addition, they may be used to fundamentally remove the cause of offensive odor by providing an air-conditioning system with an environment where the microorganisms may not live. | 2016-12-29 |
20160376629 | Use of Bacterial Beta-Lactamase for In Vitro Diagnostics and In Vivo Imaging, Diagnostics and Therapeutics - Provided herein provided is an assay system for monitoring drug susceptibility of a pathogenic bacteria comprising color-producing substrates for a beta-lactamase of the pathogenic bacteria, an assay device for visibly detecting a product of the beta-lactamase on the substrate thereof and a reader configured to quantify the visibly detected product. Also provided is an in vitro method to determine susceptibility to a drug effective against a pathogenic bacteria, for example, a pathogenic Mycobacteria, that has a beta-lactamase activity. An excitation wavelength is delivered to a biological sample obtained from a subject having an infection from the pathogenic bacteria in the presence of a beta-lactamase substrate. The intensity of a signal, such as a fluorescent, luminescent or colorimetric signal, at an emission wavelength of a product of the beta-lactamase on the subject is correlated to drug susceptibility. | 2016-12-29 |
20160376630 | PHOSPHORESCENCE-BASED HYDROGEN PEROXIDE ASSAY FOR THE DETECTION OF HYDROGEN PEROXIDE IN HUMAN SERUM AND WATER SAMPLES - The present invention relates to a method for determining an amount of a peroxide in a sample, wherein the method comprises the steps of: —providing a sample, —contacting the sample with a terbium(III) benzene dicarboxylic acid complex, and —determining the luminescence of the terbium(III) benzene dicarboxylic acid complex. | 2016-12-29 |
20160376631 | MATERIALS AND METHODS FOR RAPID VISUALIZATION OF NAD(P)H - The subject invention provides materials and methods for detecting the presence of an electron donor. In a specific embodiment, the device detects the presence of dihydronicotinamide adenine dinucleotide (NADH) via a colorimetric change output by the sensing device. In another specific embodiment, the presence of an enzyme capable of catalyzing, or an agent capable of inhibiting, the production of NADH can also be detected by a colorimetric readout using the same device. In some embodiments, dihydronicotinamide adenine dinucleotide phosphate (NADPH) can also be detected using the device provided herein. Advantageously, preferred embodiments of the subject invention provide a low-cost, sensitive device for monitoring the presence of critical biological analytes in a variety of applications. | 2016-12-29 |
20160376632 | KINASE ACTIVITY DETECTION METHODS - The invention provides a method for detecting the activities of two or more kinases. The method enables multiplexed detection with high signal to noise in a high-throughput-compatible format and a platform that could be applied to other lanthanide metal and fluorophore combinations to achieve even greater multiplexing without the need for phosphospecific antibodies. | 2016-12-29 |
20160376633 | SCHIFF-BASE CONJUGATE OF N, N-DIBUTYL-P-PHENYLENEDIAMINE WITH PYRIDOXAL 5'-PHOSPHATE FOR IMPROVED HOMOCYSTEINE ASSAYS USING PYRIDOXAL 5'-PHOSPHATE-DEPENDENT ENZYMES - A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a Schiff-based conjugate of N,N-dibutyl-p-phenyldiamine (DBPDA) with pyridoxal 5′-phosphate (PLP) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of H | 2016-12-29 |
20160376634 | HIGH-SELECTIVITY CONTACT ACTIVATION INHIBITOR BASED ON INFESTIN-4 - The present invention relates to medicine, and specifically to hematology, and can be used in particular for diagnostic and research purposes when determining coagulation characteristics of blood and its components, and also in biotechnology and fundamental biological research. | 2016-12-29 |
20160376635 | PCR KIT FOR CAPILLARY ELECTROPHORESIS - The present invention relates to a PCR kit for improving detection of particular nucleic acid motifs and for increasing the reliability of the results obtained. | 2016-12-29 |
20160376636 | COMPOSITIONS AND METHODS FOR SAMPLE PREPARATION - The invention relates generally to compositions and methods for disrupting cells (e.g., disrupting cellular and nuclear membranes). In particular, the invention provides modified solid surfaces (e.g., bead surfaces) and their use in disruption of cellular membranes (e.g., during cellular lysis procedures (e.g., for recovery of nucleic acid (e.g., DNA or RNA) from mechanical cell lysis)). Compositions and methods of the invention find use in a wide range of applications including molecular biology and medical science. | 2016-12-29 |
20160376637 | SPECIFIC DETECTION OF ORGANISMS DERIVED FROM A SAMPLE - Methods, materials, and kits for distinguishing a population of cells or organisms truly present in a clinical specimen from contaminating cells or organisms is disclosed. The methods and kits use a suppressor to avoid false positive detection of contaminants in nucleic acid amplification reactions. | 2016-12-29 |
20160376638 | QUANTITATIVE ANALYSIS METHOD USING MICROORGANISM 16S RDNA GENE HAVING SINGLE NUCLEOTIDE POLYMORPHISM - The present invention relates to utilization of an artificially synthesized nucleic acid, and more particularly, to a quantitative analysis method capable of quantitatively adjusting gene-based microbial community analysis results by preparing a microorganism 16S rDNA gene, which has a single nucleotide polymorphism (SNP) at a particular location so as to be differentiated from a gene of a target microorganism on the nucleotide sequence, and then using the microorganism 16S rDNA gene as an internal standard material which is quantifiable through nucleotide sequencing. | 2016-12-29 |
20160376639 | METHOD AND SYSTEM FOR MULTIPLEX PROFILING OF CHROMOSOMES IN BIOLOGICAL SAMPLES USING TARGET-SPECIFIC DNA PROBES - The present invention comprises methods and systems to profile individual chromosomes using target-specific DNA probes in biological samples. The invention relates to generation of chromosome profiles either singly or in combination (multiplex). The invention can refer to the generation of chromosome profiles using target-specific DNA probes for various biological samples such as cell free DNA from the peripheral blood of a pregnant woman or from a cancer patient. The invention further involving generation of chromosome profiles using target-specific DNA probes for individual intact cells from the peripheral blood of a pregnant woman, from a cancer patient or from an embryo created using artificial reproductive technologies. The invention further involving detection of target-specific DNA hybridizations through direct fluorescence by special spectral filters or fluorescence intensity by fluorimeters. Alternatively, chemiluminescent system can be used for detecting target-specific DNA hybridizations indirectly through enzyme-substrate reactions using poly-HRP as enzyme and enhanced luminol as substrate. | 2016-12-29 |
20160376640 | DETERMINATION OF EXOSOME PURITY METHODS AND APPARATUS - Methods and apparatuses for determining exosome purity are disclosed. In an example embodiment, a laboratory instrument apparatus includes an analytical centrifuge configured to rotate a solution causing a plurality of particles to separate. The analytical centrifuge is also configured to perform an interference measurement on the solution and/or three absorbance measurements on the solution. A computer processor communicatively coupled to the analytical centrifuge is configured to determine an exosome purity of the solution based on the three absorbance measurements and/or the interference measurement. | 2016-12-29 |
20160376641 | Automated RNA Detection Using Labeled 2'-O-Methyl RNA Oligonucleotide Probes and Signal Amplification Systems - Disclosed herein are methods and compositions for detecting differential expression of certain miRNAs in cancer cells or their surrounding normal tissues in the tumor microenvironment. The disclosure describes an automated, highly sensitive and specific method for detection of any cellular RNA molecule, including microRNA, messenger RNA and non-coding RNA. The technology includes probe design as well as probe use in an automated fashion for detection of RNA molecules in formalin-fixed paraffin-embedded tissue (FFPET) samples. | 2016-12-29 |
20160376642 | Localised RCA-based Amplification Method - The present invention provides a method for performing a localised RCA reaction comprising at least two rounds of RCA, wherein the product of a second RCA reaction is attached, and hence localised, to a product of a first RCA reaction, said method comprising: (a) providing a first RCA product; (b) directly or indirectly hybridising to said first RCA product a probe which comprises or provides a primer for a second RCA reaction; and (c) performing a second RCA reaction using said RCA primer of (b) to form a second RCA product, wherein in said reaction: (i) said probe and said primer are not able to prime extension using said first RCA product as template or any such extension is limited to avoid displacement of any probe hybridised to the first RCA product; (ii) the direct or indirect hybridisation of the RCA primer of (b) to the first RCA product is maintained and, by virtue of said hybridisation, the second RCA product is attached to the first RCA product; (iii) a RCA template for said second RCA reaction is comprised in or provided by the probe, or is separately provided. The method finds particular utility in the detection of analytes, wherein the analyte is a nucleic acid or wherein a nucleic acid is used or generated as a marker for the analyte. | 2016-12-29 |
20160376643 | QUANTIFICATION OF TARGET NUCLEIC ACID USING COMMON INTERNAL CONTROL - The present invention relates to a method for quantifying a target nucleic acid sequence by use of a common internal control. The present invention allows to determine an absolute initial amount of a target nucleic acid sequence with no use of a standard curve. The present invention amplifies not only a control reaction mixture comprising a known-amount standard and an internal control but also a sample reaction mixture comprising an internal control identical to the internal control in the control reaction mixture and the target nucleic acid sequence to be quantified. In the present invention, a relative ratio of the amount of the standard and the amount of the target nucleic acid sequence is calculated by using the internal control and then an initial amount of the target nucleic acid sequence is determined by using a known amount of the standard. | 2016-12-29 |
20160376644 | TARGETED SEQUENCING TECHNIQUE FOR WHOLE GENOME DNA METHYLATION - This invention is directed to a guide positioning sequencing technology of whole-genome DNA methylation. The invention provides a new detection method of nucleic acid methylation. In particular, a concept of “positioning” in the detection of nucleic acid methylation is provided. Specifically, a portion of a sequence is used for genome wide positioning and the other portion of the sequence is used for methylation detection in sequencing, thereby solving/defeating previously existing challenges in methylation detection and bioinformatics analysis of a genome. | 2016-12-29 |
20160376645 | Methods for Beaming - Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients. | 2016-12-29 |
20160376646 | NUCLEIC ACID SEQUENCING IN FREE SOLUTION USING PROTEIN POLYMER DRAG-TAGS - The present invention relates to systems, compositions, and methods for nucleic acid sequencing and analysis in free-solution using protein polymer drag-tags. As such, the present invention provides protein-based molecular compositions that find use as drag-tags for use in sequencing and nucleic acid analysis methods and provides systems and methods for automated sequencing and analysis of nucleic acids in free solution. | 2016-12-29 |
20160376647 | SEQUENCING USING CONCATEMERS OF COPIES OF SENSE AND ANTISENSE STRANDS - Methods and systems for single molecule sequencing using concatemers of copies of sense and antisense strands. Concatemers are provided, for example, by carrying out rolling circle amplification on a circular molecule having sense and antisense regions to produce repeated copies of the sense and antisense regions connected by linking regions. The circular molecules can be produced by ligating hairpin adapters to each end of a double-stranded nucleic acid having a sense and antisense strand. The ligations can be carried out, for example using blunt end ligation. In some cases, a single molecule consensus sequence for a single template molecule is obtained. A single read from each template molecule can be obtained by comparing the sequence information of the sense and antisense regions. | 2016-12-29 |
20160376648 | DIGITAL COUNTING OF INDIVIDUAL MOLECULES BY STOCHASTIC ATTACHMENT OF DIVERSE LABELS - Compositions, methods and kits are disclosed for high-sensitivity single molecule digital counting by the stochastic labeling of a collection of identical molecules by attachment of a diverse set of labels. Each copy of a molecule randomly chooses from a non-depleting reservoir of diverse labels. Detection may be by a variety of methods including hybridization based or sequencing. Molecules that would otherwise be identical in information content can be labeled to create a separately detectable product that is unique or approximately unique in a collection. This stochastic transformation relaxes the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present. The methods may be used, for example, to estimate the number of separate molecules of a given type or types within a sample. | 2016-12-29 |
20160376649 | COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS - Disclosed herein are compositions and methods for sequencing nucleic acids. | 2016-12-29 |
20160376650 | Oxidized Fraction of Extracellular DNA As A Biomarker of Stress and Methods For Using The Same - The present invention relates to methods of treating and diagnosing oxidative damage in a subject comprising administering an agent that binds oxidized extracellular nucleic acid, and methods of treating diseases and conditions in a subject comprising administering an adjuvant therapy comprising an agent that binds oxidized extracellular nucleic acid. The oxidized fraction of extracellular DNA can also be detected through electrochemical methods or by mass-spectrometry. | 2016-12-29 |
20160376651 | BIOMARKERS FOR PREMATURE BIRTH - The present invention provides a method for determining increased risk of premature birth in a pregnant woman by detecting altered expression level of one or more marker genes in the woman's blood. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for preventing or reducing the likelihood of premature birth. | 2016-12-29 |
20160376652 | COMPOSITIONS AND METHODS FOR DIAGNOSIS AND PREDICTION OF SOLID ORGAN GRAFT REJECTION - Provided herein are methods, compositions, systems, and kits for diagnosing acute rejection of solid organ transplants using at least 5 genes selected from a 10-gene panel. | 2016-12-29 |
20160376653 | Biomarkers for Determining an Allograft Tolerant Phenotype - Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression level of one or more gene in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result, where the gene expression result includes a result for a biomarker of graft tolerance. The obtained gene expression result is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen. | 2016-12-29 |
20160376654 | Temporal Pediatric Sepsis Biomarker Risk Model - Methods and compositions disclosed herein generally relate to methods of identifying, validating, and measuring clinically relevant, quantifiable biomarkers of diagnostic and therapeutic responses for blood, vascular, cardiac, and respiratory tract dysfunction, particularly as those responses relate to septic shock in pediatric patients. In particular, the invention relates to identifying one or more biomarkers associated with septic shock in pediatric patients, obtaining a sample from a pediatric patient having at least one indication of septic shock, then quantifying from the sample an amount of one or more of said biomarkers, wherein the level of said biomarker correlates with a predicted outcome. | 2016-12-29 |
20160376655 | TRPC6 INVOLVED IN GLOMERULONEPHRITIS - Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion channel protein Transient Receptor Potential Cation Channel 6. The missense mutation is a P112Q substitution, which occurs in a highly conserved region of the protein, enhances TRPC6-mediated calcium signals in response to agonists such as angiotensin II, and alters the intracellular distribution of TRPC6 protein. Previous work has emphasized the importance of cytoskeletal and structural proteins in proteinuric kidney diseases. Our findings suggest a novel mechanism for glomerular disease pathogenesis. | 2016-12-29 |
20160376656 | Single Nucleotide Polymorphism in HLA-B*15:02 and Use Thereof - Disclosed herein is a novel single nucleotide polymorphism (SNP) in HLA-B*15:02 that can be used as a biomarker for carbamazepine-induced severe adverse skin reactions in Asians. Also provided herein are methods and reagents for assessing the specific SNP, and applying the SNP in predicting an increased risk of carbamazepine-induced severe adverse skin reactions. | 2016-12-29 |
20160376657 | METHOD OF DIAGNOSING RENAL DISORDERS - The invention refers to an in vitro method of determining the risk of renal disorders, in a patient, by measuring a VCAN parameter, characterized in that at least one of the isoforms V0 and V1 are specifically determined in a sample of said patient and compared to a reference level. | 2016-12-29 |
20160376658 | SEROTONIN TRANSPORTER GENE AND TREATMENT OF ALCOHOLISM - The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders. | 2016-12-29 |
20160376659 | Breast Cancer Biomarker - The invention relates to cancer, and more specifically to breast cancer, and particularly to estrogen receptor positive breast cancer that is resistant to endocrine therapy. The invention provides methods for selecting subgroups of subjects for treatment, and methods of treatment of a subgroup of subjects. | 2016-12-29 |
20160376660 | 3.4 KB MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER - A method for detecting cancer in an individual comprising detecting a deletion in the nucleic acid sequence between residues 10743 and 12125 in mitochondrial DNA, obtaining a biological sample from the individual, extracting the mitochondrial DNA (mtDNA) from the sample, quantifying the amount of mtDNA in the sample having a deletion in the nucleic acid sequence between residues 10743 and 14125 of the mtDNA genome, and comparing the amount of mtDNA in the sample having the deletion to at least one known reference sample. | 2016-12-29 |
20160376661 | A METHOD FOR PREDICTING RESPONSIVENESS TO A TREATMENT WITH AN EGFR INHIBITOR - The present invention relates to a method for predicting whether a patient with a cancer is likely to respond to an epidermal growth factor receptor (EGFR) inhibitor, which method comprises determining the expression level of at least one target gene of hsa-miR-31-3p (SEQ ID NO:1) miRNA in a sample of said patient, wherein said target gene of hsa-miR-31-3p is selected from DBNDD2 and EPB41 L4B. The invention also relates to kits for measuring the expression of DBNDD2 and/or EPB41 L4B and at least one other parameter positively or negatively correlated to response to EGFR inhibitors. The invention also relates to therapeutic uses of an EGFR inhibitor in a patient predicted to respond to said EGFR inhibitor. | 2016-12-29 |
20160376662 | IMPROVED CERVICAL CANCER DIAGNOSING METHOD AND DIAGNOSTIC KIT FOR SAME - There are provided an improved cervical cancer diagnosing method and a diagnostic kit for same. According to the present invention, it is possible to more rapidly and accurately provide a patient group requiring a clinical treatment and a prevention treatment in terms of a technical aspect to predict that the limitation of the existing HPV DNA test method can be overcome, automate the RNA extraction from eliminated cells, and more rapidly provide more objective and accurate results because the result analysis can be performed by software by using the real-time RT-PCR. | 2016-12-29 |
20160376663 | METHODS FOR ANALYSIS OF SOMATIC MOBILE ELEMENTS, AND USES THEREOF - Methods and compositions related to the use of Mobile Element Insertions and their adjacent genomic sequences. Methods using MEIs as markers for cellular proliferation, as targets for pharmaceuticals, as markers for tissue fingerprinting and in related methods and compositions are disclosed herein. Methods and compositions relate to the detection, treatment and ongoing monitoring of cell proliferation events, cancer, and deleterious effects of mobile elements in aging, and to the selection, use and monitoring of the success of treatment regimens to address these conditions. | 2016-12-29 |