52nd week of 2021 patent applcation highlights part 32 |
Patent application number | Title | Published |
20210403970 | Production of Steviol Glycosides in Recombinant Hosts - The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors. | 2021-12-30 |
20210403971 | METHOD FOR PREPARING LIQUID MEDIUM - The invention relates to a method for preparing a liquid medium which is characterized by dissolving a desired component efficiently by controlling an amount of supplied oxygen, a liquid medium prepared by the preparation method, a method for culturing cells using the liquid medium prepared by the preparation method, a method for producing a physiologically active substance having desired quality using the culture method, and a physiologically active substance having desired quality produced by using the production method. | 2021-12-30 |
20210403972 | Novel Methods - This invention is directed to methods of detecting biofilm treated in situ with an active ingredient, and subsequently imaging or detecting types or varieties of biofilm and/or architectural changes in biofilm when treated with certain actives. Additionally, the invention contemplates screening assays to discover further candidate compounds that can affect biofilm growth and formation, as it relates to the maintenance of oral health and prevention of oral diseases. | 2021-12-30 |
20210403973 | MULTI-WELL SAMPLE TESTING APPARATUS AND METHODS OF SAMPLE TESTING USING THE SAME - A sample testing apparatus includes a sample tray defining a planar surface and a plurality of wells recessed relative to the planar surface, and a lid member configured to be sealed about the planar surface of the sample tray. The lid member includes an adhesive layer configured to be sealed to the planar surface of the sample tray, a breathable film layer disposed about the adhesive layer, and a backing layer disposed about the breathable film layer. Methods of using the sample testing apparatus for testing a sample and kits to facilitate such testing are also provided. | 2021-12-30 |
20210403974 | DEVICE FOR DETERMINING LIVE/DEAD BACTERIAL STATE AND METHOD FOR DETERMINING LIVE/DEAD BACTERIAL STATE USING THE DEVICE - Provided is a device for determining the live/dead bacterial state, with which it is possible to ascertain the accurate state of live bacteria/dead bacteria via a captured image in a relatively easy operation with which ascertaining the state of a bacterial cell is more accurate than conventional methods. This device for determining the live/dead bacterial state comprises: a case body in which a measurement mechanism is housed; an opening/closing lid body that allows a fungus base insertion port formed in the case body to be opened and closed; and the measurement mechanism, which is housed in the case body and is configured to measure the number of bacteria. The measurement mechanism comprises: a fungus base holding mechanism that inserts and fixes a fungus base on which a bacterial cell collected from a specimen is placed; an excitation light irradiating mechanism configured so as to be capable of focusing and irradiating an excitation light toward the bacterial cell on the fungus base; an imaging camera disposed above the bacterial cell on the fungus base; and an XY-axes adjustment mechanism that minutely adjusts and moves, in the XY-axes, an XY stage supporting the fungus base holding mechanism and comprising two separately moving layers. | 2021-12-30 |
20210403975 | PHENOTYPIC ANTIMICROBIAL SUSCEPTIBILITY PROFILING OF UNIDENTIFIED PATHOGENS DIRECTLY FROM PATIENT SAMPLES - The invention relates to methods for phenotypic antimicrobial susceptibility profiling of unidentified pathogens directly from patient samples and uses thereof, including providing timely important information for evidence-based management of patients with infections from unidentified pathogens. | 2021-12-30 |
20210403976 | METHODS FOR DETERMINING ANTIBIOTIC SENSITIVITY - Disclosed are approaches to determining a sensitivity of a bacterium to a given antibiotic and generating targeted treatments based on the sensitivity. One or more antibiotics may be selected for a chronic/recurrent infection resulting from a biofilm so as to reduce dose and or length of course of antibiotic treatment. For example, if a bacterial pathogen is determined to be sensitive to an antibiotic in its planktonic form but resistant to that antibiotic in its biofilm form, then the biofilm may be dispersed or disrupted from the biofilm residence in order to clear the infection. In various embodiments, a dispersal or disruption method and/or agent may be determined based at least in part on a rate of bacterial release from a biofilm that sensitizes the pathogen to a chosen antibiotic. | 2021-12-30 |
20210403977 | MICROFLUIDIC TESTING SYSTEM WITH CELL CAPTURE/ANALYSIS REGIONS FOR PROCESSING IN A PARALLEL AND SERIAL MANNER - A microfluidic chip system includes an input for receiving the biologic sample, and a first reading window for enabling a detection of the biologic material within the biologic sample. A first plurality of pathways is provided each for determining a treatment agent providing a best treatment efficacy for the predetermined biologic material. A first micro-pump is provided for pumping a portion of the biologic sample into each of the first plurality of pathways. A second plurality of pathways is provided, each for determining a dosage level of a particular one of the plurality of treatment agents with respect to the predetermined biologic material. A plurality of second micro-pumps are provided for pumping a second portion of the biologic sample into a selected one of the second plurality of pathways responsive to the determination of treatment efficacy of the treatment agent providing a best treatment of the predetermined biologic material. | 2021-12-30 |
20210403978 | METHODS FOR DETECTING AGGLUTINATION AND COMPOSITIONS FOR USE IN PRACTICING THE SAME - Methods are provided for detecting antigen binding agents in samples. Aspects of the methods include detection of the aggregation of antigen binding agents with polynucleotide-bound antigens by sensitive proximity-based association of the anti-gen-bound polynucleotides. Aspects of the methods also include methods for the detection of such proximity-based association through nucleic acid amplification. In addition, compositions, e.g., reagents, kits, and devices, useful in practicing various embodiments of the methods are provided. | 2021-12-30 |
20210403979 | METHODS AND DEVICES RELATED TO TOEHOLD-BASED STRAND DISPLACEMENT WITH LOOP-MEDIATED ISOTHERMAL AMPLIFICATION - Disclosed are methods for isothermal nucleic acid amplification and detection. | 2021-12-30 |
20210403980 | METHODS OF MULTIPLEX dPCR ASSAYS AND SHORT-READ SEQUENCING ASSAYS - Provided herein are methods of multiplex digital PCR assays and short-read sequencing assays. The methods described herein utilize high-throughput sample distribution techniques, fluorescent channel monitoring, and nucleic acid sequence melting curve analysis. | 2021-12-30 |
20210403981 | EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH CYCLING PROBE - Described herein are methods and compositions that provide highly efficient nucleic acid amplification and signal detection using a cycling probe. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases. | 2021-12-30 |
20210403982 | MULTIPHASE NUCLEIC ACID AMPLIFICATION - Improved methods for use in nucleic acid amplification, including multiplex amplification, where the amplification is carried out in two or more distinct phases are disclosed. The first phase amplification reaction preferably lacks one or more components required for exponential amplification. The lacking component is subsequently provided in a second, third or further phase(s) of amplification, resulting in a rapid exponential amplification reaction. The multiphase protocol results in faster and more sensitive detection and lower variability at low analyte concentrations. Compositions for carrying out the claimed methods are also disclosed. | 2021-12-30 |
20210403983 | COMPOSITIONS AND METHODS FOR DETECTING VIRAL NUCLEIC ACIDS - Described herein are compositions that may be used to detect viral nucleic acid. For example, these compositions may comprise a DNA-nanostructure, a capture oligonucleotide and a protector oligonucleotide, wherein the components are designed based on a duo-toehold-mediated displacement reaction (duo-TMDR) strategy. In this strategy, a first TMDR can switch off a Faster resonance energy transfer (FRET) process and a second TMDR can release the target viral nucleic acid and amplify the signal. Methods of using such compositions are also provided herein. | 2021-12-30 |
20210403984 | IN VITRO EVALUATION METHOD FOR RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ASSOCIATED WITH SMOKING OR INHALATION - The present invention relates to an in vitro method for evaluating the risk of chronic obstructive pulmonary disease associated with smoking or inhalation. The method of the present invention comprises: (1) calculating probability P | 2021-12-30 |
20210403985 | PHOTOPROTECTIVE MIXTURES AS IMAGING REAGENTS IN SEQUENCING-BY-SYNTHESIS - The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods. In particular, the present invention contemplates the use of photoprotective mixture of compounds as imaging reagents to improve stability and storage of fluorescent compounds, including but not limited to, nucleotides with fluorescent labels. | 2021-12-30 |
20210403986 | DETECTION AND PREDICTION OF INFECTIOUS DISEASE - Provided herein are fragment length profiles of nucleic acid libraries, methods of generating fragment length profiles of nucleic acid libraries and methods of using fragment length profiles for diagnostics and/or prognostics. The application further provides methods, compositions and kits for determining the infection stage or the site of localization in a subject. | 2021-12-30 |
20210403987 | Methods and Compositions for Determining pH - Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence C | 2021-12-30 |
20210403988 | DNA NANOTECHNOLOGY-BASED BIOMARKER MEASUREMENT PLATFORM - A biomarker signal amplifier amplifies chemical analyte binding and includes: a surface strand disposed on an analysis substrate and including an exchange region; a particle strand hybridized to the surface strand in an absence of a chemical analyte that preferentially hybridizes to the exchange region as compared with the particle strand, and the particle strand is dissociated from the surface strand when the surface strand is in a presence of the chemical analyte; and a reporter particle attached to the particle strand and disposed proximate to the analysis substrate when the particle strand is hybridized to the surface strand in absence of the chemical analyte and that changes the electrical potential of the analysis substrate depending on whether the particle strand is hybridized to the surface strand. | 2021-12-30 |
20210403989 | BARCODING METHODS AND COMPOSITIONS - Barcoding composition and methods involving solid supports having sets of different oligonucleotides that can be decoded to the same identification sequence. | 2021-12-30 |
20210403990 | DIGITAL AMPLIFICATION FOR PROTEIN DETECTION - The present disclosure provides a method of measuring the quantity of analyte molecules. In some aspects, the method comprises compartmentalizing a sample with binding molecules conjugated to synthetic nucleic acid molecules such that the interaction of the binding molecules with the analyte molecules brings the nucleic acid molecules into proximity. Proximity triggers reactions that result in an optical signal, such as fluorescence, in analyte-containing compartments which can be counted to determine the quantity of analyte present. | 2021-12-30 |
20210403991 | Sequencing Process - The present invention relates to methods for generating sequences of template nucleic acid molecules, methods for determining sequences of at least two template nucleic acid molecules, computer programs adapted to perform the methods and computer readable media storing the computer programs. In particular the present invention relates to methods for generating sequences of at least one individual target template nucleic acid molecule comprising: a) providing at least one sample of nucleic acid molecules comprising at least two target template nucleic acid molecules; b) introducing a first molecular tag into one end of each of the at least two target template nucleic acid molecules and a second molecular tag into the other end of each of the at least two target template nucleic acid molecules to provide at least two tagged template nucleic acid molecules wherein each of the at least two tagged template nucleic acid molecules is tagged with a unique first molecular tag and a unique second molecular tag; c) amplifying the at least two tagged template nucleic acid molecules to provide multiple copies of the at least two tagged template nucleic acid molecules comprising the first molecular tag and the second molecular tag; d) sequencing regions of the at least two tagged template nucleic acid molecules comprising the first molecular tag and the second molecular tag; and e) reconstructing a consensus sequence for at least one of the at least two target template nucleic acid molecules. | 2021-12-30 |
20210403992 | METHOD COMBINING SINGLE CELL GENE EXPRESSION MAPPING AND TARGETED RNA OR c-DNA SEQUENCING USING PADLOCK OLIGONUCLEOTIDES COMPRISING A BARCODE REGION - Microscopy imaging that allow for multiple mRNAs to be resolved at a single cell level provides valuable information regarding transcript amount and localization, which is a crucial factor for understanding tissue heterogeneity, the molecular development and treatment of diseases. The current invention describes a method (Fly FISH) which combined the use of padlock oligonucleotides as fluorescence in situ hybridization (FISH) probes for detection and sequencing targeted portion of RNA or cDNA transcript at a cellular level with less limitation in the amount of transcripts and the length of the sequence that can be analyzed. Padlocks probes containing various barcodes in their core are utilized both as FISH probes and also to capture RNA portion that can be sequenced. The same barcodes can be used to selectively prime a rolling circle amplification and amplify a subset of transcripts coming from a specific region that have been tagged as of interest during the probing steps. | 2021-12-30 |
20210403993 | CATALYTICALLY CONTROLLED SEQUENCING BY SYNTHESIS TO PRODUCE SCARLESS DNA - The present disclosure relates to methods comprising (a) contacting a polymerase with a template polynucleotide and a plurality of free nucleotides, wherein the template polynucleotide is hybridized to a complementary polynucleotide comprising a 3′ end overhung by a 5′ terminal fragment of the template polynucleotide, and the plurality of free nucleotides comprise a compound Formula (I); wherein said contacting occurs under a complexation condition, the complexation condition effective to form a complex but not effective to form polymerization, wherein the complex comprises the polymerase, the template polynucleotide, the complementary polynucleotide, and one of the plurality of free nucleotides that is complementary to a first nucleotide of the 5′ terminal fragment of the template polynucleotide; (b) detecting a signal from the fluorescent label; and (c) exposing the complex to a polymerization condition. | 2021-12-30 |
20210403994 | METHODS FOR RAPID DNA EXTRACTION FROM TISSUE AND LIBRARY PREPARATION FOR NANOPORE-BASED SEQUENCING - The present disclosure relates to improved methods for preparing, sequencing and analyzing short DNA fragments using handheld, nanopore-based sequencing technology as well as improved methods for extracting DNA, in particular genomic DNA, for any downstream application. | 2021-12-30 |
20210403995 | HIGH-THROUGHPUT METHODS TO CHARACTERIZE PHAGE RECEPTORS AND RATIONAL FORMULATION OF PHAGE COCKTAILS - The present invention provides for a method for screening for gene function for a bacteriophage, the method comprising: (1) (a) providing one or more host organism, such as a species or strain, libraries, (b) providing randomly barcoded transposon sequencing (such as RB-TnSeq), and (c) screening for loss-of-function (LOF) mutant phenotypes; or (2) (a) providing one or more DNA barcoded overexpression strain libraries (such as Dub-seq) using DNA of the host organism and/or phage, and (b) screening for gain-of-function (GOF). | 2021-12-30 |
20210403996 | METHOD FOR DIAGNOSING DRUG ADDICTION, METHOD FOR SCREENING THERAPEUTIC AGENT FOR DRUG ADDICTION AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DRUG ADDICTION - Disclosed is a composition for diagnosing, preventing or treating drug addiction based on synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP). SYNCRIP or a gene encoding the protein can be used to diagnose drug addiction. In addition, a therapeutic agent for drug addiction can be discovered by measuring the expression of SYNCRIP. Furthermore, an agent expressing SYNCRIP or promoting the activity of SYNCRIP can be used to prevent or treat drug addiction. | 2021-12-30 |
20210403997 | DEVICE, NUCLEIC ACID TESTING METHOD AND NUCLEIC ACID TESTING DEVICE, AND GENE TESTING METHOD - Provided is a device including a well provided in a number of at least one, wherein a nucleic acid having at least one of a full-length nucleotide sequence and a partial nucleotide sequence of rRNA or rDNA is contained in a defined copy number in at least one well of the well, and wherein the defined copy number of the nucleic acid having at least one of a full-length nucleotide sequence and a partial nucleotide sequence of rRNA or rDNA is 1,000 or less. | 2021-12-30 |
20210403998 | CHEMICAL COMPOSITIONS AND USES THEREOF - The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies. | 2021-12-30 |
20210403999 | CHEMICAL COMPOSITIONS AND USES THEREOF - The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies. | 2021-12-30 |
20210404000 | METHODS AND COMPOSITIONS FOR PREDICTING CHRONIC LUNG ALLOGRAFT DYSFUNCTION - Some embodiments are directed to a prognostic method for determining whether a subject is at risk of having the CLAD, comprising: measuring the expression level of POU2AF1 or BLK in a biological sample obtained from the subject; comparing the expression level of POU2AF1 or BLK with a predetermined reference value and concluding that the subject is at risk of having CLAD when the expression level of POU2AF1 or BLK is lower than the predetermined reference value. | 2021-12-30 |
20210404001 | BIOMARKER FOR DIAGNOSING OR PREDICTING REACTIVITY OF OVARY TO FSH AND USE THEREOF - Provided is a biomarker for diagnosing or predicting reactivity of an ovary to FSH and use thereof. According to a composition or a kit for diagnosing or predicting reactivity of an ovary to FSH and a method using the same according to one aspect, the degree of reactivity of the ovary may be easily diagnosed using miRNA present in blood, follicular fluid, granulosa cells, and cumulus cells, and thus it is easy to predict or diagnose symptoms or diseases caused by abnormal reactivity of the ovary to FSH. | 2021-12-30 |
20210404002 | Quantitative Algorithm for Endometriosis - Disclosed herein are methods for developing and using quantitative algorithms, cutoff points, and numerical scores based upon the expression level of at least one miRNA that is associated with endometriosis. | 2021-12-30 |
20210404003 | DNA METHYLATION AND GENOTYPE SPECIFIC BIOMARKER FOR PREDICTING POST-TRAUMATIC STRESS DISORDER - The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one embodiment, a method for predicting PTSD in a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3′ untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3′ UTR of SKA2, and (c) predicting PTSD in the subject using a prediction algorithm. | 2021-12-30 |
20210404004 | TH17 DIFFERENTIATION MARKERS FOR ACNE AND USES THEREOF - A method is described for using IL-12Rβ1/IL-23R, CCR6, BATF, AHR, STAT3, IRF4 crucial actors in TH17 cells differentiation as markers for acne. Also described are methods of their use to diagnose acne, and to screen inhibitors of Th17 differentiation. In particular, methods are described for inhibiting IL12Rβ1/1L-23R, CCR6, BATF, AHR, STAT3, IRF4 and the use of these screened inhibitors in acne treatment. | 2021-12-30 |
20210404005 | Salivary Extracellular Rna Biomarkers for Gingivitis - Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject. | 2021-12-30 |
20210404006 | Salivary Extracellular Rna Biomarkers for Gingivitis - Described herein are methods used for the detection of gingivitis and the monitoring of gingivitis in a subject. | 2021-12-30 |
20210404007 | METHODS AND SYSTEMS FOR EVALUATING DNA METHYLATION IN CELL-FREE DNA - The present disclosure concerns embodiments related to methods of enriching particular DNA for analysis of methylation status and/or profiles, for example in the process of diagnosis of cancer. In particular embodiments, the methods utilize cell-free DNA as a source of DNA instead of genomic DNA and allow for focused enrichment of fragments having two or more enzyme digestion sites and containing at least one CpG site. | 2021-12-30 |
20210404008 | PROGNOSIS BIOMARKERS FOR TRIPLE-NEGATIVE BREAST CANCER - A microRNA (miRNA) expression signature for predicting triple-negative breast cancer (TNBC) recurrence is provided. The miRNA expression signature consists essentially of hsa-miR-139-5p, hsa-miR-10b-5p, hsa-miR-486-5p, hsa-miR-455-3p, hsa-miR-107, hsa-miR-146b-5p, hsa-miR-324-5p, and hsa-miR-20a-5p. | 2021-12-30 |
20210404009 | METHOD FOR DETERMINING RISK OF UROTHELIAL CARCINOMA - A method for determining a risk of urothelial carcinoma may be based on the methylation level of DNA. A method for determining a risk of canceration of a urothelial tissue may involve detecting the DNA methylation level of a CpG site of at least one gene selected from TENM3, HOXC4, TLR1, CPVL and PRDM16 in genomic DNA preferably derived from a urothelial cell or a tissue containing the urothelial cell; and determining a risk of canceration of the urothelial tissue from the detected DNA methylation level. | 2021-12-30 |
20210404010 | DETECTION OF COLORECTAL NEOPLASMS - The present disclosure provides, among other things, methods for colorectal neoplasm detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for adenoma and/or early stage colorectal cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR and/or using massively parallel sequencing (e.g., next-generation sequencing). | 2021-12-30 |
20210404011 | SYSTEMS AND METHODS FOR DETECTION OF MULTIPLE CANCER TYPES - The present disclosure provides, among other things, methods for colorectal cancer, breast cancer, lung cancer and/or pancreatic cancer detection (e.g., screening) and compositions related thereto. In various embodiments, the present disclosure provides methods for screening that include analysis of methylation status of one or more methylation biomarkers, and compositions related thereto. In various embodiments, the present disclosure provides methods for detection (e.g., screening) that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA. In various embodiments, the present disclosure provides methods for screening that include detecting (e.g., screening) methylation status of one or more methylation biomarkers in cfDNA, e.g., in ctDNA, using MSRE-qPCR and/or using massively parallel sequencing (e.g., next-generation sequencing). | 2021-12-30 |
20210404012 | INHIBITOR OF ATR KINASE FOR USE IN A METHOD OF TREATING A HYPER-PROLIFERATIVE DISEASE - The present invention covers 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine (in the following called “Compound A”), an inhibitor of ATR kinase, for use in a method of treating a hyper-proliferative disease in a subject. Preferably the hyper-proliferative disease or the subject is characterized by one or more biomarker(s) selected from
| 2021-12-30 |
20210404013 | METHOD FOR IDENTIFYING A MEDICAL CONDITION IN A SUBJECT - The present disclosure discloses an in-vitro and non-invasive method for detecting a medical condition in a subject. The method involves enriching very small embryonic like stem cells from the sample, to obtain a mixture comprising said very small embryonic like stem cells; obtaining nucleic acid from the mixture of step; performing an assay with the nucleic acid for analysing expression level of Oct4A in the very small embryonic like stem cells from the sample; and comparing the expression level of Oct4A in the very small embryonic like stem cells from the sample with an expression level of Oct4A in a control sample. The present disclosure also provides a method for predicting the onset of cancer and for predicting the presence of cancer. A method of treating cancer is also disclosed herein. Moreover, a reagent kit and a detection kit are also disclosed. | 2021-12-30 |
20210404014 | METHODS OF DIAGNOSING AND TREATING CANCER IN PATIENTS HAVING OR DEVELOPING RESISTANCE TO A FIRST CANCER THERAPY - A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided. | 2021-12-30 |
20210404015 | MUTATION DETECTION ASSAY - A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the genomic locus, to produce an amplified sample, where: i. the amplifying is done using a first primer and a second primer; and ii. the first primer comprises a 3′ terminal nucleotide that base pairs with the point mutation and also comprises a nucleotide sequence that is fully complementary to a sequence in the locus with the exception of a single base mismatch within 6 bases of the 3′ terminal nucleotide; and b) detecting the presence of said product in said amplified sample using a flap assay that employs an invasive oligonucleotide. A kit for performing the method is also provided. | 2021-12-30 |
20210404016 | CLASSIFICATION OF SUBTYPES OF KIDNEY TUMORS USING DNA METHYLATION - A method of classifying kidney tumors is provided. The method includes obtaining a sample from a subject, isolating DNA from the sample, determining the methylation status of the DNA, and comparing the methylation status of the DNA to one or more methylated biomarkers selected from the following: cg04877910, cg09667289, cg05274650, cg11473616, cg16935734, cg27534624, cg21851713, cg15867829, cg15679829, cg08884979, cg09538401, cg26811868, cg05367028, cg19816080, cg20108357, cg25504868, cg11201447, cg19922137, cg14706317, cg15902830, cg10794973, cg10777887, cg03290131, cg07851269, cg11264947, cg00279406, cg23140965, cg03574652, cg03265671, cg24864241, cg01572891, cg00193963, cg14329285, cg17819990, cg17298239, cg23856138, cg21049501, cg11808936, cg25170591, cg17983632, cg08141142, cg19848599, cg25799109, cg07093324, cg16223546, cg07604732, cg12149606, cg08949329, cg27166177, cg26177041, cg09885851, cg22876153, cg21386992, cg02309772, cg02833180, cg20007890, cg04972244, cg02666955 and cg12102682. The comparison indicates whether the sample is clear cell malignant, papillary malignant, chromophobe malignant, angiomylolipomas (AML) benign, or oncocytoma benign. | 2021-12-30 |
20210404017 | ANALYTICAL METHOD AND KIT - According to one embodiment, there is provided an analytical method for determining the presence or absence of contraction of cancer in a subject. The method includes quantifying hsa-miR-1301-3p in a sample originating from the subject. | 2021-12-30 |
20210404018 | UNBIASED DNA METHYLATION MARKERS DEFINE AN EXTENSIVE FIELD DEFECT IN HISTOLOGICALLY NORMAL PROSTATE TISSUES ASSOCIATED WITH PROSTATE CANCER: NEW BIOMARKERS FOR MEN WITH PROSTATE CANCER - A method of detecting the presence of a prostate cancer field defect in a human subject. The method includes (a) obtaining genomic DNA from the human subject and (b) determining methylation status in at least one target region selected from the group consisting of PLA2G16, CAV1, EVX1, MCF2L, FGF1, NCR2, WNT2, EXT1, and SPAG4, wherein methylation changes indicate the presence of prostate cancer or a prostate cancer field defect, wherein the change is relative to tissue from a second human subject who does not have prostate cancer. | 2021-12-30 |
20210404019 | METHODS FOR ANALYZING A TARGET NUCLEIC ACID FROM RED BLOOD CELLS - The invention provides a lysis reagent for lysing red blood cells, thereby releasing a target, such as RNA from a parasitic organism, in a form suitable for analysis. The reagent includes at least ammonium chloride and an anionic detergent, and may include an anti-coagulant. The reagent serves to lyse red blood cells, protect the released target from degradation in the lysate, and is compatible with subsequent steps for analysis of the target such as target capture, amplification, detection, or sequencing. | 2021-12-30 |
20210404020 | POROUS MATERIAL FOR THE DETECTION OF CANDIDA ALBICANS, DIAGNOSTIC METHOD USING SAME AND PREPARATION METHOD THEREOF - Specifically, the invention describes obtaining a new porous material prepared to recognise DNA of the pathogenic microorganism | 2021-12-30 |
20210404021 | METHOD, KIT, AND PROGRAM FOR DETERMINING CHARACTERISTIC OF TUMOR CELL GROUP - According to one embodiment, a method for determining a characteristic of a tumor cell group, the method includes bringing a lipid particle including a lipid membrane and a first nucleic acid included in the lipid membrane into contact with the tumor cell group (the first nucleic acid including a promoter sequence of a marker gene for determining the characteristic and a reporter gene linked to a downstream of the promoter sequence to be functionable), culturing the tumor cell group, detecting the presence or absence or an amount of a signal from a reporter protein that is expressed from the reporter gene, in each tumor cell included in the tumor cell group, and counting the number of tumor cells having the characteristic that is measured from a result of the detecting. | 2021-12-30 |
20210404022 | SYSTEMS AND METHODS FOR ANALYTE TESTING AND LABORATORY OVERSIGHT - In one embodiment, a method is provided comprising analyte testing on one or more types of samples. | 2021-12-30 |
20210404023 | NOVEL CORONAVIRUS DUPLEX DETECTION KIT - The present invention provides a novel coronavirus duplex detection kit. Specifically, the present invention discloses a kit and method for multiplex detection of novel coronavirus 2019-nCoV nucleic acid, which can simultaneously detect two nucleic acid targets of the novel coronavirus 2019-nCoV and possess extremely high sensitivity and specificity, and significantly improve the accuracy of virus identification. | 2021-12-30 |
20210404024 | Rapid Diagnostic Test for LAMP - Kits and methods are described that are directed to specific and sensitive methods of target nucleic acid detection and more specifically detecting target nucleic acids directly from biological samples. The kits and methods were developed to be easy to use involving a minimum number of steps and giving rapid and consistent results either at point of care or in high throughput situations. The kits and methods utilize in various combinations, reversible inhibitors of kit components, thermolabile enzymes, poloxamers, various salts, indicators and one or more Loop-Mediated Isothermal Amplification (LAMP) primer sets for detecting single and/or multiple targets and variants of the targets including SARS-CoV-2 targets and variants thereof in a single reaction. The kits and methods permit detection of the target nucleic with similar sensitivity regardless of the presence of undefined mutations that may enhance the virulence of cells or viruses containing the undefined mutations. | 2021-12-30 |
20210404025 | CONTINUOUS METHOD FOR OBTAINING A CRYSTALLINE MONOSACCHARIDE AND DEVICE FOR CONTINUOUS CRYSTALLIZATION - The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer ( | 2021-12-30 |
20210404026 | HIDE SORTING SYSTEMS AND METHODS - Methods and systems for sorting hides are provided. In particular, one or more embodiments comprise a tanning control system that enhances the traceability of hides by capturing and utilizing data related to the unloading, tanning, sorting, and packaging of hides. Furthermore, one or more embodiments enable the tanning control system to improve efficiency by sorting hides based, at least in part, on data generated during prior tanning processes. Additionally, one or more embodiments facilitate the tanning control system in customizing the sorting and packaging of hides based, at least in part, on one or more hide characteristics and/or customer specifications. | 2021-12-30 |
20210404027 | MACHINE COMPONENT - A machine component, made of steel or cast iron and having a circular hole that opens in a first surface, includes a plurality of first quench-hardened regions that include the first surface and are arranged apart from each other along a first circle surrounding the hole when viewed in a plane in a direction perpendicular to the first surface, and a base region that is a region other than the first quench-hardened regions. | 2021-12-30 |
20210404028 | HIGH STRENGTH AND TOUGHNESS LOW CARBON NANOSTRUCTURED BAINITIC STEEL AND PREPARATION METHOD THEREOF - A nanostructured bainitic steel of low carbon comprising of the following components in percentage by mass: Carbon—(0.24-0.28%), Manganese—(1.8-2%), Silicon—(2-2.5%), Nickel—(1.5-1.8%), Molybdenum—(0.2-0.25%), Chromium—(0.2-0.25%), Aluminium—(0.2-0.25%), and Cobalt—(0.45-0.5%) and the balance being Iron and unavoidable impurities and a method for preparation thereof. | 2021-12-30 |
20210404029 | HEAT TREATMENT INSTALLATION FOR PRODUCING SHAPED COMPONENTS - There are disclosed a heat treatment installation and a method of producing shaped components having at least two microstructural regions of different ductility or strength from semi-finished products of hardenable steel, using a continuous furnace which permits heating of the semi-finished products to a first temperature in a first region and permits heating of the semi-finished products to a second temperature, which differs from the first temperature, in a second region. The two regions are separated from one another by partition walls extending in the transport direction, and the continuous furnace includes a lifting-step chain conveyor as a transport device. | 2021-12-30 |
20210404030 | STEEL FOR BOLTS, AND METHOD OF MANUFACTURING SAME - Disclosed is a non-heat-treated steel that has low deformation resistance during cold forging in bolt head forming and excellent product yield, and that can be manufactured without the need to perform heat treatment for controlling strength variation. The disclosed steel has a chemical composition containing C: 0.18-0.24%, Si: 0.10-0.22%, Mn: 0.60-1.00%, Al: 0.010-0.050%, Cr: 0.65-0.95%, Ti: 0.010-0.050%, B: 0.0015-0.0050%, N: 0.0050-0.0100%, P: 0.025% or less inclusive of 0, S: 0.025% or less inclusive of 0, Cu: 0.20% or less inclusive of 0, and Ni: 0.30% or less inclusive of 0, in a range satisfying: 0.45≤C+Si/24+Mn/6+Ni/40+Cr/5≤0.60 and N≤0.519A1+0.292Ti, with the balance being Fe and inevitable impurities; and a microstructure in which bainite is present in an area ratio of 95% or more, where the microstructure contains prior austenite grains with a grain size number of 6 or more, and strength variation is 100 MPa or less. | 2021-12-30 |
20210404031 | STEEL MATERIAL HAVING LOW YIELD RATIO AND EXCELLENT HEAT AFFECTED ZONE TOUGHNESS AND MANUFACTURING METHOD THEREFOR - The present invention relates to a steel material used as materials for building structures, ship structures, offshore structures, or the like and, more specifically, to a steel material having low yield ratio and excellent weld heat affected zone toughness and a manufacturing method therefor. | 2021-12-30 |
20210404032 | A METHOD OF MANUFACTURING MARTENSITIC STEEL AND A MARTENSITIC STEEL THEREOF - A martensitic steel including the following elements, expressed in percentage by weight 0.1%≤C≤0.4%; 0.2%≤Mn≤2%; 0.4%≤Si≤2%; 0.2%≤Cr≤1%; 0.01%≤Al≤1%; 0%≤S≤0.09%; 0%≤P≤0.09%; 0%≤N≤0.09%; and can contain one or more of the following optional elements 0%≤Ni≤1%; 0%≤Cu≤1%; 0%≤Mo≤0.1%; 0%≤Nb≤0.1%; 0%≤Ti≤0.1%; 0%≤V≤0.1%; 0.0015%≤B≤0.005%; 0%≤Sn≤0.1%; 0%≤Pb≤0.1%; 0%≤Sb≤0.1%; 0%≤Ca≤0.1%; the remainder composition being composed of iron and unavoidable impurities caused by processing, the microstructure of said steel having microstructure by area percentage including cumulative presence of residual austenite and bainite between 0% and 25%, the remaining microstructure being martensite at least 70%, and with an optional presence of ferrite between 0% and 10%. | 2021-12-30 |
20210404033 | DEVICE AND METHOD FOR CONTINUOUS TEMPERATURE GRADIENT HEAT TREATMENT OF ROD-SHAPED MATERIAL - A device and a method for continuous temperature gradient heat treatment of a rod-shaped material are disclosed. The furnace body of the device includes an upper heating zone and a lower heating zone inside, which are independently controlled in temperature by means of an upper heating power supply and a lower heating power supply. Moreover, both the upper heating zone and the lower heating zone are closed heating zones. The closed heat insulation plates could prevent heat loss and ensure precise temperature control of the upper heating zone and the lower heating zone. In the device, a vacuum pumping equipment is included; an annular radiation screen is configured between the upper heating zone and the lower heating zone, and the rod-shaped material is not in contact with the annular radiation screen. The rod-shaped material conducts one-dimensional heat transfer along the axial direction. | 2021-12-30 |
20210404034 | COPPER ALLOY FOR ENGINE VALVE SEATS MANUFACTURED BY LASER CLADDING - A copper alloy for engine valve seats manufactured by laser cladding improves wear resistance of the copper alloy. The copper alloy includes 12 to 24 wt % of Ni, 2 to 4 wt % of Si, 4 to 12 wt % of Mo, 15 to 35 wt % of Fe, and the remaining wt % of Cu and impurities. | 2021-12-30 |
20210404035 | CORROSION AND WEAR RESISTANT NICKEL BASED ALLOYS - Disclosed herein are embodiments of nickel-based alloys. The nickel-based alloys can be used as feedstock for PTA and laser cladding hardfacing processes, and can be manufactured into cored wires used to form hardfacing layers. The nickel-based alloys can have high corrosion resistance and large numbers of hard phases such as isolated hypereutectic hard phases. | 2021-12-30 |
20210404036 | COBALT BASED ALLOY PRODUCT AND METHOD FOR MANUFACTURING SAME - There is provided a cobalt-based alloy product comprising: in mass %, 0.08-0.25% C; 0.1% or less B; 10-30% Cr; 5% or less Fe and 30% or less Ni, the total amount of Fe and Ni being 30% or less; W and/or Mo, the total amount of W and Mo being 5-12%; at least one of Ti, Zr, Hf, V, Nb and Ta, the total amount of Ti, Zr, Hf, V, Nb and Ta being 0.5-2%; 0.5% or less Si; 0.5% or less Mn; 0.003-0.04% N; and the balance being Co and impurities. The product is a polycrystalline body of matrix phase crystal grains. In the matrix phase crystal grains, post-segregation cells with an average size of 0.13-2 μm are formed, wherein components constituting an MC type carbide phase comprising Ti, Zr, Hf, V, Nb and/or Ta are segregated along boundary regions of the post-segregation cells. | 2021-12-30 |
20210404037 | 7XXX-SERIES ALUMINIUM ALLOY PRODUCT - The invention relates to a wrought 7xxx-series aluminium alloy product having a composition comprising, in wt. %., Zn 6.20 to 7.50, Mg 2.15 to 2.75, Cu 1.20 to 2.00, and wherein Cu+Mg<4.50, and wherein Mg<2.5+5/3(Cu-1.2), Fe up to 0.25, Si 0 up to 0.25, and optionally one or more elements selected from the group consisting of: (Zrup to 0.3,Crup to 0.3,Mnup to 0.45,Tiup to 0.25, Scup to 0.5, Agup to 0.5), the balance being aluminium and impurities. | 2021-12-30 |
20210404038 | 2XXX ALUMINUM LITHIUM ALLOYS - New 2xxx aluminum alloys having are disclosed. The new 2xxx aluminum alloys generally include 2.5-3.9 wt. % Cu, 0.82-1.20 wt. % Li, 0.5-2.0 wt. % Zn, 0.10-0.60 wt. % Mn, 0.05-0.35 wt. % Mg, from 0.05 to 0.50 wt. % of at least one grain structure control element, wherein the at least one grain structure control element is selected from the group consisting of Zr, Sc, Cr, V, Hf, other rare earth elements, and combinations thereof, up to 0.22 wt. % Ag, up to 0.15 wt. % Fe, up to 0.12 wt. % Si, and up to 0.15 wt. % Ti, the balance being aluminum, incidental elements and impurities. The new 2xxx aluminum alloys may realize an improved combination of two or more of strength, fracture toughness, elongation, and corrosion resistance. | 2021-12-30 |
20210404039 | STEEL WIRE ROD ENABLING OMISSION OF SOFTENING HEAT TREATMENT AND METHOD OF MANUFACTURING SAME - The present disclosure relates to a steel wire rod enabling the omission of softening heat treatment and a method of manufacturing same. An embodiment of the present disclosure provides a steel wire rod enabling the omission of softening heat treatment and a method of manufacturing same, the steel wire rod comprising, in weight %, 0.2-0.45% of C, 0.02-0.4% of Si, 0.3-1.5% of Mn, 0.01-1.5% of Cr, 0.02-0.05% of Al, 0.01-0.5% of Mo, 0.01% or less of N, and the balance Fe and other unavoidable impurities, wherein the microstructure of the steel wire rod is a composite structure of proeutectoid ferrite+perlite as a main phase; the steel wire rod contains 10 area % or less (including 0%) of at least one of bainite or martensite; and the average colony size of the perlite is 5 μm or less. | 2021-12-30 |
20210404040 | HOT-ROLLED STEEL SHEET - A hot-rolled steel sheet includes, as chemical composition, C, Si, Mn, and sol.Al. In the hot-rolled steel sheet, a sum of an average of pole densities in a crystal orientation group consisting of {211}<111> to {111}<112> and a pole density in a crystal orientation of {110}<001> is 0.5 to 6.0 in the surface region, and the tensile strength is 780 to 1370 MPa. | 2021-12-30 |
20210404041 | METHOD FOR PREPARING HIGH-STRENGTH, DISSOLVABLE MAGNESIUM ALLOY MATERIAL - A method for preparing a high-strength, dissolvable magnesium alloy material includes steps of: (1) preparing a magnesium-nickel intermediate alloy, which is Mg25Ni or Mg30Ni; (2) loading; (3) heating, melting and alloying; and (4) refining adequately alloyed magnesium melt at 750±20° C. for about 5 minutes while using RJ-6 as a refining flux and setting the melt still for about 10 minutes. The method allows easy addition of nickel as a component to a magnesium alloy during smelting such that nickel is evenly distributed throughout the magnesium alloy. | 2021-12-30 |
20210404042 | TITANIUM ALUMINIDE ALLOY MATERIAL FOR HOT FORGING, FORGING METHOD FOR TITANIUM ALUMINIDE ALLOY MATERIAL, AND FORGED BODY - A titanium aluminide alloy material for hot forging has a chemical composition including, by atom, aluminum of 43.0% or greater and 45.0% or less, niobium of 4.0% or greater and 6.0% or less, chromium of 1.5% or greater and 3.5% or less, and titanium and an inevitable impurity as a residue. | 2021-12-30 |
20210404043 | SNOUT FOR USE IN A HOT DIP COATING LINE - A continuous coating line includes a snout assembly exposed to molten metal. The snout assembly includes a snout tip positioned about a steel strip that is immersible in the molten metal to provide a seal around the steel strip during entry into the molten metal. The snout tip includes a refractory material that is resistant to wear, abrasion, and corrosion when the snout tip is exposed to the molten metal. | 2021-12-30 |
20210404044 | THERMAL SPRAYED COATING FOR SLIDING MEMBER, AND SLIDING DEVICE PROVIDED WITH THERMAL SPRAYED COATING FOR SLIDING MEMBER - A sprayed coating for a sliding member of the present invention includes a ferrous alloy containing iron (Fe) as a major ingredient. | 2021-12-30 |
20210404045 | METHOD OF MANUFACTURING FIBER REINFORCED BARRIER COATING - A method of manufacturing a fiber reinforced coating. The method includes providing a substrate and plasma spraying a ceramic matrix having fibers encapsulated in a precursor material onto the substrate. | 2021-12-30 |
20210404046 | High Pressure Oxidation of Metal Films - Methods of processing thin film by oxidation at high pressure are described. The methods are generally performed at pressures greater than 2 bar. The methods can be performed at lower temperatures and have shorter exposure times than similar methods performed at lower pressures. Some methods relate to oxidizing tungsten films to form self-aligned pillars. | 2021-12-30 |
20210404047 | CARBURIZER AND CARBURIZATION METHOD USING THE SAME - A carburizer, which effects carburization with respect to molten iron accommodated in an electric furnace or a ladle, includes a mixture of quicklime and a carbon material having an ash content of from 5 mass % to 18 mass %, and satisfies the conditions 0.6≤(mc+Mc)/ms≤2.7 and 0.7≤(mc+Mc)/ma≤6.5. A method of carburization uses this carburizer. Here, mc represents the mass of CaO in the carbon material, ms represents the mass of SiO | 2021-12-30 |
20210404048 | MASK SHEET AND PIXEL STRUCTURE - The disclosure provides a mask sheet and a pixel structure. The mask sheet includes a mask opening configured to manufacture a sub-pixel in a pixel opening of a display panel. An area of the mask opening is greater than an area of the pixel opening corresponding thereto. The pixel opening includes at least one curved edge with an inner concave surface, the mask opening includes at least one mask edge, and the at least one mask sheet is in one-to-one correspondence with the at least one curved edge. A curvature of each mask edge is less than a curvature of the curved edge corresponding thereto. | 2021-12-30 |
20210404049 | MASK AND MANUFACTURING METHOD THEREOF, FINE METAL MASK, MASK DEVICE AND USE METHOD THEREOF - A mask, a manufacturing method thereof, a fine metal mask, a mask device and a use method thereof are provided. The mask includes at least one opening region and a shielding part surrounding and defining the at least one opening region. The shielding part includes a main part and at least one protrusion, in each opening region, the protrusion is protruded towards the opening region on a side of the main part facing the opening region; the main part includes an edge disposed on a side of the protrusion opposite to the opening region and with an extension direction being a same with an extension direction of the protrusion, he protrusion and a portion of the main part disposed between the edge and the protrusion includes a thinning portion with a thickness being less than a thickness of other portions of the shielding part. | 2021-12-30 |
20210404050 | PLASMA SPRAY PHYSICAL VAPOR DEPOSITION DEPOSITED IN MULTILAYER, MULTI-MICROSTRUCTURE ENVIRONMENTAL BARRIER COATING - An article may include a substrate defining at least one at least partially obstructed surface. The substrate includes at least one of a ceramic or a ceramic matrix composite. The article also may include a multilayer, multi-microstructure environmental barrier coating on the at least partially obstructed substrate. The multilayer, multi-microstructure environmental barrier coating includes a first layer comprising a rare earth disilicate and a substantially dense microstructure; and a second layer on the first layer. The second layer includes a columnar microstructure and at least one of a rare earth monosilicate or a thermal barrier coating composition comprising a base oxide comprising zirconia or hafnia; a primary dopant comprising ytterbia; a first co-dopant comprising samaria; and a second co-dopant comprising at least one of lutetia, scandia, ceria, gadolinia, neodymia, or europia. | 2021-12-30 |
20210404051 | ION BEAM DEPOSITION OF A LOW RESISTIVITY METAL - Methods for forming thin, low resistivity metal layers, such as tungsten (W) and ruthenium (Ru) layers. The methods include depositing a metal material onto a substrate via ion beam deposition with assist in a process chamber at a temperature of at least 250° C. to produce the metal film. A resulting thin tungsten film has large and highly oriented α(110) grains having a resistivity less than 9 μΩ-cm and thickness less than 300 Å, with no discernable β-phase. A resulting thin ruthenium film has a resistivity less than 10 μΩ-cm and a thickness less than 300 Å. | 2021-12-30 |
20210404052 | HARD COATING FOR CUTTING TOOL - A hard coating for cutting tools according to the present invention is a hard coating for cutting tools which is formed on and adjacent to a hard base material by a PVD method, and is characterized in that the thickness of the entire hard coating is 0.5 to 10 μm, and the hard coating includes one or more nitride layers and one or more oxide layers. Each of the one or more nitride layers has a thickness of 0.1 to 5.0 μm and is composed of Al | 2021-12-30 |
20210404053 | ARGON-HELIUM BASED COATING - A sputtering system may include a substrate. The sputtering system may include at least one target. The at least one target may include at least one coating material to coat at least one layer onto the substrate. The at least one coating material may be sputtered onto the substrate in a presence of an inert gas. The inert gas may include argon gas and helium gas. | 2021-12-30 |
20210404054 | Highly-ordered nano-structure array and Fabricating Method thereof - A highly-ordered nano-structure array, formed on a substrate, mainly comprises a plurality of highly-ordered nano-structure units. Each of the highly-ordered nano-structure units forms a receiving compartment. One end of the receiving compartment opposite to the substrate has an opening. Each of the highly-ordered nano-structure units comprises at least one thin film layer. A periphery and a bottom of the receiving compartment are defined by an inner surface of a surrounding portion of the at least one thin film layer and a top surface of a bottom portion of the at least one thin film layer, respectively. The at least one thin film layer is made of at least one material selected from the group consisting of: metal, alloy, oxide, nitride, and sulfide. | 2021-12-30 |
20210404055 | Hard Mask Deposition Using Direct Current Superimposed Radio Frequency Plasma - A method of forming a carbon hard mask includes generating a radio frequency plasma including carbon-based ions by supplying continuous wave radio frequency power to a plasma processing chamber. The carbon-based ions have a first average ion energy. The method further includes adjusting the first average ion energy of the carbon-based ions to a second average ion energy by supplying continuous wave direct current power to the plasma processing chamber concurrently with the continuous wave radio frequency power and forming a carbon hard mask at a substrate within the plasma processing chamber by delivering the carbon-based ions having the second average ion energy to the substrate. | 2021-12-30 |
20210404056 | ULTRA-THIN FILMS WITH TRANSITION METAL DICHALCOGENIDES - Methods for selectively forming a transition metal dichalcogenide (TMDC) film comprise exposing a substrate comprising a silicon oxide-based surface and a tungsten (W) segment to a sulfur source to selectively form the transition metal dichalcogenide film with the tungsten segment relative to the silicon oxide-based surface. Chemical vapor deposition (CVD) at a temperature in a range of 350° C. to 600° C. is used to form the TMDC film. CVD may be conducted by low pressure CVD (LPCVD) or atmospheric pressure CVD (APCVD). Methods of making devices incorporating the TMDC films are also provided. | 2021-12-30 |
20210404057 | LOW TEMPERATURE METHODS FOR DEPOSITING INORGANIC PARTICLES ON A METAL SUBSTRATE AND ARTICLES PRODUCED BY THE SAME - Methods for depositing inorganic particles including titanium carbonitride on a metal substrate via chemical vapor deposition (CVD). In some embodiments, the CVD process may be supplied by two or more source gasses that react to form the inorganic particles. At least one of the sources gases includes a titanium source gas. And a source of carbon and nitrogen may be (a) a single source gas including a carbon and nitrogen source gas with a heat of formation energy that is less than 65.9 kilojoules per mole and/or (b) two source gases including a carbon source gas with a gas molecule having a carbon-nitrogen single bond and a nitrogen source gas. In some embodiments, the CVD process may be supplied by a source gas including a metalorganic compound to form the inorganic particles. In some embodiments, the CVD process may be supplied by an aluminum-containing metalorganic reducing agent. | 2021-12-30 |
20210404058 | APPARATUS AND METHODS TO REDUCE PARTICLES IN A FILM DEPOSITION CHAMBER - Apparatus and methods for supplying a vapor to a processing chamber such as a film deposition chamber are described. The vapor delivery apparatus comprises an inlet conduit and an outlet conduit, in fluid communication with an ampoule. A needle valve device restricts flow through the outlet conduit. | 2021-12-30 |
20210404059 | PROCESSING SYSTEM AND METHOD OF CONTROLLING CONDUCTANCE IN A PROCESSING SYSTEM - Embodiments provided herein generally relate to a processing system and a method of controlling conductance in a processing system. The processing system and method disclosed herein allow for control of gas ratios within the processing system, while still maintaining a high level of conductance. The processing system includes a purge gas valve configured to pulse a flow of foreline purge gas. The method includes pulsing the foreline purge gas. The method is contained in a computer readable medium. The pulsed foreline purge gas can maintain a ratio of process purge gas and the process gas in the processing region. | 2021-12-30 |
20210404060 | VAPOR DEPOSITION OF TUNGSTEN FILMS - Vapor deposition methods for depositing tungsten-containing thin films are provided. In some embodiments a substrate is contacted with a vapor phase first reactant comprising a tungsten precursor, such as a tungsten oxyhalide, a second reactant such as CO, and a third reactant such as H | 2021-12-30 |
20210404061 | ATOMIC LAYER SELF ALIGNED SUBSTRATE PROCESSING AND INTEGRATED TOOLSET - Apparatus and methods to process one or more wafers are described. A substrate is exposed to a plurality of process stations to deposit, anneal, treat and optionally etch a film in small increments to provide self-aligned growth of the film on a substrate surface. | 2021-12-30 |
20210404062 | Atomic Layer Self Aligned Substrate Processing and Integrated Toolset - Apparatus and methods to process one or more wafers are described. A substrate is exposed to a plurality of process stations to deposit, anneal, treat and optionally etch a film in small increments to provide self-aligned growth of the film on a substrate surface. | 2021-12-30 |
20210404063 | Particle Coating Method And Particle Coating Apparatus - A particle coating method includes placing magnetic particles in a vessel, fixing the magnetic particles by a magnetic force caused by a magnetic field generated in the vessel, and forming a coating film on surfaces of the magnetic particles by an atomic layer deposition method. Further, the method preferably includes forming a coating film on surfaces of the magnetic particles by an atomic layer deposition method in a state where the magnetic particles are fixed by the magnetic force in a first direction, thereby obtaining coated magnetic particles, and forming a coating film on surfaces of the coated magnetic particles in a state where the coated magnetic particles are fixed by the magnetic force in a second direction different from the first direction. | 2021-12-30 |
20210404064 | Showerhead for Process Tool - In one example, an apparatus includes a processing chamber; a substrate holder disposed in the processing chamber; and a showerhead disposed over the substrate holder. The showerhead includes a first zone disposed in a central region of the showerhead, the first zone including a first cavity, a plurality of first fluid exit holes aligned to output a fluid from the first cavity towards the substrate holder, a first flow path fluidly coupled to a fluid source, and a plurality of first fluid distribution pathways fluidly coupling the first flow path with the first cavity. | 2021-12-30 |
20210404065 | METHODS AND APPARATUS FOR ADJUSTING WAFER PERFORMANCE USING MULTIPLE RF GENERATORS - Methods and apparatus for controlling a semiconductor process leverage phase shifting between at least two RF generators to improve wafer performance parameters. In some embodiments, an apparatus may include a first radio frequency (RF) generator, a second RF frequency generator, a cable connected between the first RF generator and the second RF generator wherein the cable is configured to synchronize the first RF generator and the second RF generator, and an adjustable phase shift assembly with a two-dimensional trace and an adjustable contact point. The adjustable phase shift assembly is connected to the cable and configured to alter at least one water performance parameter by changing a phase shift relationship between the first RF frequency generator and the second RF frequency generator. | 2021-12-30 |
20210404066 | METAL MEMBER AND PRODUCTION METHOD THEREFOR - A metal member includes a metal substrate, a first intermediate plating layer, a second intermediate plating layer, and a precious metal plating layer. The metal substrate includes a surface constituted of a plurality of crystal grains. The first intermediate plating layer is directly formed on the plurality of crystal grains of the metal substrate, contains a nickel element, and is non-oriented with respect to each crystal orientation of the plurality of crystal grains of the metal substrate. The second intermediate plating layer is directly formed on the first intermediate plating layer. The precious metal plating layer is formed on the second intermediate plating layer. | 2021-12-30 |
20210404067 | Structural Element and Method for Producing a Structural Element - A structural part includes a pocket where the pocket is formed during or after a production of the structural part. A coating material is disposed in the pocket where the coating material at least partially fills the pocket. A method for producing a structural part includes removing or reducing material in a portion of a structural part to produce or form a pocket during or after a forming of the structural part and filling the pocket with a coating material by a coating method. | 2021-12-30 |
20210404068 | ETCHING SOLUTION, ANNEXING AGENT, AND MANUFACTURING METHOD OF METAL WIRING - An etching solution, an annexing agent, and a manufacturing method of a metal wiring are disclosed. A main ingredient of the etching solution includes hydrogen peroxide accounting for 5% to 30% of a total weight of the etching solution, a hydrogen peroxide stabilizer accounting for 0.1% to 5% of the total weight of the etching solution, a chelant accounting for 5% to 25% of the total weight of the etching solution, a surface active agent accounting for 0.1% to 1% of the total weight of the etching solution, an inorganic acid oxidant accounting for 0.1% to 5% of the total weight of the etching solution, and a remainder of the etching solution is deionized water. The annexing agent is added to the etching solution when the etching solution is used repeatedly. | 2021-12-30 |
20210404069 | ELECTROLYTIC GENERATORS - In accordance with the principals of the present invention, an electrolytic generator and method of electrolytic generation are provided. An electrolytic stack includes of a first electrode, a second electrode, and a polymer-electrolyte membrane placed between the first and second electrodes. A first fluid passage provides fluid passage over the first electrode while a second fluid passage provides fluid passage over the second electrode. A third fluid passage provides fluid connection between the first fluid passage and the second fluid passage such that the fluid flows from the first fluid passage to the second fluid passage via the third fluid passage. An electronic current is provided between the first electrode and the second electrode when a voltage bias is applied to the electrodes. | 2021-12-30 |