53rd week of 2009 patent applcation highlights part 46 |
Patent application number | Title | Published |
20090324677 | POLYMER CONJUGATES OF BOX-A OF HMGB1 AND BOX-A VARIANTS OF HMGB1 - The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE. | 2009-12-31 |
20090324678 | Methods and kits for treating joints and soft tissues - Methods to treat and provide pain relief for damaged and degenerated tissues of a musculoskeletal joint are disclosed. These methods include introducing into, around and/or on the musculoskeletal joint an effective amount of a pharmaceutical composition containing a biocompatible matrix or biocompatible polymeric compound, a pain reliever, and a corticosteroid formulated for extended-release, wherein at least a portion of the biocompatible matrix or biocompatible polymeric compound is activated and polymerized in situ. Also disclosed is a composition for treating a damaged or degenerated joint or soft tissue. The composition contains a polymerizable material capable of forming a biocompatible and biodegradable matrix in situ at a treatment site, a pain reliever; and a corticosteroid formulated for extended-release. | 2009-12-31 |
20090324679 | MEDICAL COPOLYMERS - According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of —C═C— groups within the polymer backbone, (ii) a plurality of -R | 2009-12-31 |
20090324680 | NANOFIBER-REINFORCED COMPOSITION FOR APPLICATION TO SURGICAL WOUNDS - A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein. The viscosity of the composition is such that it is able to be applied through a tube yet adhere proximate the wound site to provide a barrier layer which assists in healing of the wound by spacing it from neighboring organs. | 2009-12-31 |
20090324681 | Vascularization Enhanced Graft Constructs - A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided. | 2009-12-31 |
20090324682 | Medical stent provided with inhibitors of atp synthesis - A stent provided with a composition having at least one type of inhibitor of ATP synthesis, optionally together with at least one inhibitor of the pentose phosphate pathway is disclosed. The medical stent is useful for treating stenosis and preventing restenosis in vascular ducts and for treating cancerous tumors present in ducts, resectioned cavities and scars and any disorder arising from the proliferation of cells in ducts or cavities. | 2009-12-31 |
20090324683 | CONTROLLED RELEASE TISSUE GRAFT COMBINATION BIOMATERIALS - In one aspect, the invention relates to tissue graft combination biomaterials capable of controlled release of bioactive agents or pharmaceutically active agents through a rate-controlling polymer coating encapsulating the graft material, methods for preparing same, methods of controlled release using same, and methods for treating tissue defects. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 2009-12-31 |
20090324684 | MEDICAL DEVICES HAVING SURFACE COATINGS - According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid. | 2009-12-31 |
20090324685 | MEDICAL DEVICE COATINGS CONTAINING CHARGED MATERIALS - In accordance with certain aspects of the present invention, medical devices are provided which are configured for implantation or insertion into a subject. The medical devices include at least one coating region that comprises (a) a charged polyamino-acid-containing polymer having a first net charge and (b) an additional charged polymer having a second net charge that is opposite in sign to that of the first net charge. The additional charged polymer may or may not be a polyamino-acid-containing polymer. | 2009-12-31 |
20090324686 | TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration. | 2009-12-31 |
20090324687 | TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration. | 2009-12-31 |
20090324688 | TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration. | 2009-12-31 |
20090324689 | TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration. | 2009-12-31 |
20090324690 | TRANSSCLERAL DELIVERY - Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration. | 2009-12-31 |
20090324691 | METHODS AND OPHTHALMIC DEVICES USED IN THE TREATMENT OF OCULAR ALLERGIES - Ophthalmic devices containing anti-allergic agents and methods of preparing the same are disclosed herein. | 2009-12-31 |
20090324692 | Polyurethane Elastomers - A linear polymer is obtained by reacting together a polyethylene glycol or polypropylene glycol; a PEG-PPG-PEG or PPG-PEG-PPG block copolymer; a difunctional amine or diol; and a diisocyanate. A controlled release composition comprises the polymer together with an active agent. Active agents of molecular weight 200 to 20,000 may be used. | 2009-12-31 |
20090324693 | Delivery Product for Topical Compositions - A delivery product is used to deliver a skin composition to the skin of a user. The delivery product includes a thermo-responsive polymer film. The polymer film is solid at room temperature but, once contacted with the skin, increases in temperature and degrades. A skin composition is associated with the polymer film. The skin composition can be applied to a surface of the film or can be incorporated into the film. The skin composition is released by the polymer film for treating the skin of the user. | 2009-12-31 |
20090324694 | GASTRORETENTIVE DRUG DELIVERY SYSTEM COMPRISING AN EXTRUDED HYDRATABLE POLYMER - According to the present invention there is provided a pharmaceutical product for retention in the stomach. The product is produced by extrusion. The use of extrusion enables the product to take many useful forms. The product may comprise a sheet of hydratable polymer, the hydrated sheet being of a size which will not pass out of the stomach, for example a shaped sheet or a roll. The product may also comprise a scaled hollow tubular extrudate, for example a tube scaled at both ends. The product may comprise a filled capsule. | 2009-12-31 |
20090324695 | BIOCOMPATIBLE POLYMER CERAMIC COMPOSITE MATRICES - Biocompatible composites of flexible polymers/copolymers films and dispersed solid silica-based ceramic microparticles are provided. The composites uniquely combine material and drug delivery properties that are essential for wound dressings and drug delivery applications. The flexible copolymer films are preferably tyrosine-based polycarbonates, and the ceramic microparticles are biodegradable silica-based glass particles that are preferably processed by a sol-gel methodology. The copolymers and the ceramic microparticles independently can contain therapeutic agents, are independently capable of binding these agents, and can independently release such agents. It is sufficient that either the polymer or the ceramic contains therapeutic agents, although both may contain them. | 2009-12-31 |
20090324696 | NAIL PATCH - The present subject matter provides a nail patch comprising a backing layer and a pressure-sensitive adhesive layer disposed on at least one side of the backing layer, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive base, terbinafine and/or a pharmacologically acceptable salt thereof, and sodium acetate and/or sorbitan monolaurate as a solubilizer. | 2009-12-31 |
20090324697 | TRANSDERMAL HORMONE DELIVERY SYSTEM: COMPOSITIONS AND METHODS - A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed. | 2009-12-31 |
20090324698 | LIPOSOMAL COMPOSITION COMPRISING AN ACTIVE INGREDIENT FOR RELAXING SMOOTH MUSCLE, THE PRODUCTION OF THIS COMPOSITION AND THE THERAPEUTIC USE THEREOF - The invention relates to a pharmaceutical composition made from an active ingredient included in liposomes for topical application, whereby the liposomes have an aqueous medium in the interior thereof and contain at least one active ingredient therein which exerts a direct or indirect relaxing effect on smooth musculature and is preferably selected from the group of prostaglandins, adenylate cyclases, cAMP, AMP, ATP, NO-synthetases, nitrogen monoxide (NO), NO compounds, nitrates, guanylate cyclases, cGMP, GMP, GTP and phosphodiesterases, in particular, Sildenafil. The invention further relates to a method for production of said composition, optionally, in sterile form and the use of the liposomes supporting the active ingredient in various galenic forms for external application in the genital region, for prophylaxis and/or therapy of sexual disorders in men or women and/or for increase of sexual sensitivity. | 2009-12-31 |
20090324699 | Antihistamine-and corticosteroid-containing lipsome composition and its use for the manufacture of medicament for treating rhinitis and related disorders - There is provided homogeneous pharmaceutical compositions for the treatment of, for example, rhinitis, asthma and/or chronic obstructive pulmonary disease comprising a corticosteroid and an antihistamine, a polar lipid liposome and a pharmaceutical-acceptable aqueous carrier. | 2009-12-31 |
20090324700 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF CATHEPSINS - Methods and compositions for modulating cell death by contacting a cell with an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. In addition, methods of treating a subject by providing the subject a composition that includes an Spi2A polypeptide or an Spi2A polypeptide equivalent are disclosed. The Spi2A polypeptide and Spi2A polypeptide equivalent can be delivered to the subject using gene therapy techniques. The subject can be a patient with a disease associated with an abnormal rate of cell death, such as septic shock or myocardial infarction. Also disclosed are methods of preparing and storing donor granulocytes, involving contacting the donor granulocytes with an Spi2A polypeptide or an Spi2A polypeptide equivalent. | 2009-12-31 |
20090324701 | COMPOSITIONS CONTAINING (S)-BETHANECHOL AND THEIR USE IN THE TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, GLUCOSE INTOLERANCE AND RELATED DISORDERS - The present invention provides pharmaceutical compositions comprising (S)-bethanechol or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier and optionally at least one diabetes drug. The use of said composition in the treatment of insulin resistance, type 2 diabetes, impaired glucose tolerance and related disorders is also provided. The invention also provides for a kit comprising the pharmaceutical compositions and instructions for its use. | 2009-12-31 |
20090324702 | NOVEL VIRAL VECTOR - The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza; and methods for preventing and treating infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; pharmaceuticals containing the recombinant baculovirus as an active ingredient; and methods for preventing and treating infectious diseases such as malaria and influenza comprising administrating the recombinant baculovirus to patients. | 2009-12-31 |
20090324703 | Bioavailable curcuminoid formulations for treating alzheimer's disease and other age-related disorders - Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided. | 2009-12-31 |
20090324704 | PHOSPHATE DIESTER AMIDES - The present invention relates to lipid-analogous phosphoric acid compounds and in particular phosphoric triesters, phosphoric diester amides and phosphoric diesters. These are preferably cationic phospholipids preferably having at least one free hydroxyl group. | 2009-12-31 |
20090324705 | PHYTONUTRIENT COMPOSITIONS FOR TOPICAL USE - Topical anti-oxidant liposomal phytonutrient formulations and methods for their use such as the treatment of skin inflammation and skin-lightening applications. | 2009-12-31 |
20090324706 | Nanostructures Suitable for Sequestering Cholesterol and Other Molecules - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 2009-12-31 |
20090324707 | METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES - The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same. | 2009-12-31 |
20090324708 | COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND A METHOD FOR THE TREATMENT OF RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION - The present invention relates to a compound having inhibitory activity on a Rho-GTPase cell protein, the compound having the formula I (Formula I) wherein A is selected from N and N—H, R | 2009-12-31 |
20090324709 | LIPOSOMAL FORMULATIONS - The invention relates to formulations of hydrophilic substances encapsulated in liposomes, to the method of encapsulation of the hydrophilic substances in the liposomes and the use of said formulations in the prevention and/or treatment of diseases and/or disorders in humans and animals. | 2009-12-31 |
20090324710 | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor - Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided. | 2009-12-31 |
20090324711 | Oral Pharmaceutical Composition of Anilinopyrimidine, Preparation and Use Thereof - An oral pharmaceutical composition comprising a capsule dosage form containing a liquid fill composition including an anilinopyrimidine derivative of Formula (I) and a pharmaceutically acceptable excipient selected from the group consisting of polyethylene glycol, a glyceryl ester of capric acid or a mixture thereof. The liquid fill composition is formulated in a hard gelatin capsules and can be used for the preparation of a medicament for the treatment of cancer in particular AML. | 2009-12-31 |
20090324712 | METHODS AND COMPOSITIONS RELATED TO PRODUCTION OF COENZYME Q10 - Disclosed are methods, compounds, and compositions related to the production of coenzyme Q. | 2009-12-31 |
20090324713 | SPRAY-ON, NON-WOVEN FABRIC SYSTEM AND MULTILAYER WOUND COVERINGS - The invention is directed to a spray-on, non-woven fabric system and multilayer wound coverings for promoting wound healing, where the fabric system includes a first spray-on composition including a non-volatile carrier for keeping the wound moist and a second spray-on composition for covering the first composition and protecting the wound which includes fibers, a volatile carrier, and a binding agent, and where the multilayer wound covering includes a first layer formed from the first spray-on composition and a second layer covering the first layer, the second layer formed from the second spray-on composition. | 2009-12-31 |
20090324714 | DUAL ADHESIVE TECHNOLOGY - A dual adhesive layer dosage form for delivery of active agent to and across, the mucosa is disclosed. Particularly, bioadhesive tablets for administration at the vaginal mucosa are disclosed as having a central active layer sandwiched between two bioadhesive layers. | 2009-12-31 |
20090324715 | HIGH DOSE ORAL PHARMACEUTICAL COMPOSITIONS OF ARTEMETHER AND LUMEFANTRINE - The present invention relates to high dose oral pharmaceutical compositions of artemether and lumefantrine, and process for preparation thereof. The compositions comprise of artemether and lumefantrine comprising artemether in an amount of from about 40 mg to about 80 mg, lumefantrine in an amount of from about 240 mg to about 480 mg. The compositions are useful for treatment of uncomplicated infections with | 2009-12-31 |
20090324716 | Coated Particles Containing Pharmaceutically Active Agents - The present invention features a tablet including particles containing a pharmaceutically active agent, wherein the particles are coated with (a) a first film layer containing a modified release polymer; and (b) a second film layer containing (i) a first polymer, wherein the first polymer is a polymer of ethyl acrylate and methyl methacrylate and (ii) a second polymer, wherein the second polymer is a polymer of methyl acrylate, methyl methacrylate and methacrylic acid. | 2009-12-31 |
20090324717 | Extended release pharmaceutical formulation of metoprolol and process for its preparation - The invention provides an extended release coated granule comprising a granule having a particle size ranging from 0.2 to 2 mm, a friability lower than or equal to 1% and comprising metoprolol succinate as active ingredient in an amount ranging from 10 to 75% by weight of the granule and at least one binder selected from microcrystalline cellulose and methylcellulose, coated with a film-former coating agent. It also provides a process for the preparation of said extended release coated granules, as well as pharmaceutical formulations containing them. | 2009-12-31 |
20090324718 | IMATINIB COMPOSITIONS - Provided are compositions of imatinib, methods for their preparation, and methods for treatment using the same. | 2009-12-31 |
20090324719 | EXTRACELLULAR MATRIX COMPOSITION - The invention relates to a process for preparing an extracellular matrix composition comprising cross-linked fibrinogen or a derivative thereof, to an extracellular matrix composition obtained by said process and to the use of said composition in wound healing, tissue regeneration or as a tissue engineering scaffold. | 2009-12-31 |
20090324720 | BIOCOMPATIBLE CROSSLINKED HYDROGELS, DRUG-LOADED HYDROGELS AND METHODS OF USING THE SAME - Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels. | 2009-12-31 |
20090324721 | Hydrogels Suitable For Use In Polyp Removal - Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. In embodiments, the biocompatible crosslinked polymers and/or their precursors may be utilized in a surgical procedure, such as a polypectomy. | 2009-12-31 |
20090324722 | CARTILAGE FILLING DEVICE - Compositions and methods for treating a tissue defect. | 2009-12-31 |
20090324723 | Method of prophylaxis of infection - A method for prophylaxis of infection of the respiratory tract of a subject by pathogenic airborne bacteria the method comprising administering to the subject by inhalation binding proteins directed against the bacteria. the pathogenic bacteria is a bacteria which survives inside phagocytes and the binding proteins are directed against said bacteria which survives inside phagocytes. The binding proteins comprise antibodies or antibody fragments directed against said bacteria which survives inside phagocytes. The binding proteins are selected from the group consisting of polyclonal antibodies, monoclonal antibodies, F(ab) fragments, F(ab′) | 2009-12-31 |
20090324724 | SOLUBLE AMIDE & ESTER PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS - The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers. | 2009-12-31 |
20090324725 | PEG-MODIFIED HYDROXYAPATITE, PHARMACEUTICAL USING THE SAME AS BASE MATERIAL AND PRODUCTION PROCESS THEREOF - The present invention provides a PEG-modified HAP having a high degree of safety and novel functions by modifying the surface of hydroxyapatite particles with a polyethylene glycol derivative, applications thereof, and a production process of the same. The PEG-modified HAP of the present invention is a substance in which hydroxyapatite having a particle diameter of 50 μm to 10 nm is bonded to a polyethylene glycol derivative having a carboxyl group as a terminal functional group through —O(CO) bonds, and the carbon content thereof is 10 to 0.1%. In addition, the present invention is a substance composed of this substance and a pharmaceutical active ingredient or pharmaceutical additive, in which the weight ratio of the pharmaceutical active ingredient is 1 to 30%, and the substance is obtained by treating hydroxyapatite having a particle diameter of 50 μm to 10 nm and an active ester of polyethylene glycol derivative having a carboxyl group as a terminal functional group in an anhydrous organic solvent. | 2009-12-31 |
20090324726 | Non-Viral Gene Therapy Using Chitosan-Containing Nanoparticles - The present invention concerns a new drug delivery system and more particularly, a non-viral drug delivery system comprising a polymer according to the following formula and useful for treating a disease characterized by over-expression of folic acid receptors on the cell surface. | 2009-12-31 |
20090324727 | NANOEMULSION - The present invention relates to a nanoemulsion comprising at least one aqueous component and a carrier, wherein the carrier comprises at least one lipophilic component, at least one surfactant and at least one alcohol, characterised in that at least one alcohol has at least three carbon atoms. The present invention further relates to a composition comprising said nanoemulsion and an active agent. In particular, the composition is present as a gel and the active agent is 5-aminolevulinic acid, a derivative, precursor and/or metabolite thereof. The invention further relates to the preparation of said nanoemulsion and/or composition and to their use for the treatment of dermatological diseases, virus-associated diseases as well as diseases associated with cell proliferation, in particular, tumor diseases and/or psoriasis. The present invention is further directed to the use of said nanoemulsion in cosmetics. | 2009-12-31 |
20090324728 | PHARMACEUTICAL COMPOSITIONS COMPRISING AMORPHOUS BENZIMIDAZOLE COMPOUNDS - Compositions comprising amorphous substituted benzimidazole compounds. | 2009-12-31 |
20090324729 | USE OF SOLID CARRIER PARTICLES TO IMPROVE THE PROCESSABILITY OF A PHARMACEUTICAL AGENT - The invention provides a composition comprising, a compound of formula (I): | 2009-12-31 |
20090324730 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SYMPTOMS OF COMPLEX REGIONAL PAIN SYNDROME - A therapeutic composition for the treatment of the symptoms of complex regional pain syndrome and the method for preparing the therapeutic agents is disclosed. The therapeutic composition is a stable pharmaceutical composition comprising one or more digestive and/or pancreatic enzymes. The therapeutic composition may be manufactured by a variety of encapsulation technologies. Delivery of the therapeutic composition may be made orally, through injection, by adherence of a medicated patch or other method. Further, a method of using fecal chymotrypsin level as a biomarker for the presence of complex regional pain syndrome, or the likelihood of an individual to develop complex regional pain syndrome is disclosed. | 2009-12-31 |
20090324731 | Method for Making Biodegradable Superabsorbent Particles - A method for making particles containing carboxyalkyl cellulose, comprising blending a carboxyalkyl cellulose and a starch in water to provide an aqueous gel; treating the aqueous gel with a crosslinking agent to provide a crosslinked gel; drying the crosslinked gel to provide a solid; comminuting the solid to provide a plurality of particles. | 2009-12-31 |
20090324732 | METHOD FOR THE PRODUCTION OF MILK OR MILK PRODUCTS WITH A HIGH PROPORTION OF MELATONIN - A method for the production of milk with increased melatonin content or a milk product made therefrom. The method comprises dividing the daily cycle of a female mammal into a daytime phase under a first light regime with a proportion of blue light and a night-time phase under a second light regime and milking the mammal at least once during the night-time phase in order to obtain milk with an increased melatonin content. For the second light regime there is used at least one light source which emits light in the wavelength range of 500 nm or above and substantially no light in the wavelength range below 500 nm. | 2009-12-31 |
20090324733 | Composition of Whey Growth Factor Extract for Reducing Muscle Inflammation - The invention relates to the production of compositions containing milk products for use as a nutritional supplement. More specifically, it relates to compositions containing whey growth factor extract, as well as their use in methods for reducing muscle inflammation in individuals undertaking resistance exercise training. According to one aspect of the invention, there is provided the use of a composition comprising whey growth factor extract, isolated from a milk product by cation exchange chromatography, to reduce exercise-induced muscle inflammation. | 2009-12-31 |
20090324734 | THROAT CARE COMPOSITION - A throat care composition including water, honey, vegetable glycerine, natural lemon flavor, at least one of liquefied slippery elm and liquefied marshmallow root, grape seed extract and malic acid. In at least one embodiment, the throat care composition is applied via a spray applicator. | 2009-12-31 |
20090324736 | METHODS OF TREATING BOWEL DISEASES BY ADMINISTERING A BOWEL CLEANSER AND AN ANTIBIOTIC - The present invention relates to formulations and kits for the treatment of bowel disease, to their use in medicinal preparations and to therapeutic methods thereof. | 2009-12-31 |
20090324737 | Antimicrobial And Sporicidal Composition - Germicidal compositions with enhanced activity towards killing microbiological spores and vegetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores. | 2009-12-31 |
20090324738 | METHODS FOR MAKING ANTIMICROBIAL COATINGS - Methods for forming antimicrobial coatings on substrate surfaces are disclosed. The methods involve providing a mixture comprising a metal salt, a biguanide compound, and a reducing agent, wherein the mixture is free of polymeric binders; and depositing the mixture onto a substrate surface, thereby forming a coated substrate surface. | 2009-12-31 |
20090324739 | Antibacterial Composition Containing Organic Silver Complexes, Antibacterial Treatment Methods Using the Same and Antibacterial Formed Article - The present invention relates to antibacterial composition containing silver complexes, antibacterial treatment methods using the same and antibacterial formed article, in which the antibacterial composition containing silver complexes is economical, not wearing off due to washing, cleaning, rubbing, etc., firmly combined to improve durability and antibacterial effect, and applicable to various products due to great solubility and stability. | 2009-12-31 |
20090324740 | NOVEL NASAL SPRAY - Systems and methods are disclosed for treating a plurality of sinsousal conditions to be treated. These systems and methods include selecting a combination of at least two compounds that are capable of addressing a plurality of sinsousal conditions. At least one of the at least two compounds is selected from a group of anti fungals, antioxidants, and chelators. These systems and methods also include verifying that the compounds are biologically compatible and creating a combination compound using the selected compounds. | 2009-12-31 |
20090324741 | INJECTABLE POLYMER-LIPID BLEND - An injectable polymer-lipid blend is provided. The blend may provide a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery. | 2009-12-31 |
20090324742 | Peham dendrimers as excipients - The present invention concerns poly(etherhydroxylamine) PEHAM dendritic polymers wherein they function as excipients for the enhancement of water solubility of poorly water soluble (hydrophobic) Active Materials or enhancement of oil solubility of poorly oil soluble (hydrophilic) Active Materials. These dendritic polymers can have Active Materials associated with them by one or more of the following: (a) by adsorption onto the surface or (b) encapsulation into the interior of the dendritic polymers or (c) a mixture of both where these interactions are driven by one or more of the following (i) electrostatic attraction, (ii) hydrogen bonding between dendritic polymers and Active Material and (iii) hydrophobic or hydrophilic interactions or mixtures of these interactions. Additionally, these associated Active Materials can be associated with dendritic polymers through chemical bonding to the surface or to internal functionalities (IF) of PEHAM dendritic polymers or both. Such bonding is done either directly between PEHAM dendritic polymers and Active Material molecules or via a linker that can have a hydrolysable bond to the Active Material. In addition, a chemical entity with strong interaction to the Active Material and dendritic polymers can be associated with the dendritic polymer prior to adsorption or encapsulation of the Active Material or together with the Active Material. | 2009-12-31 |
20090324743 | PULMONARY DRUG DELIVERY - The present invention relates to formulations for delivery of drugs to the respiratory tract, especially the lungs, as well as improved methods of treating subjects suffering or predisposed to suffering from lung conditions/diseases. The invention is particularly directed to lung cancer treatment using, for example, cytotoxic platinum-based drugs. | 2009-12-31 |
20090324744 | Effective Antitumor Treatments - ET-743 is used in the preparation of a medicament for an effective treatment of a tumour by combination therapy employing ET-743 with another drug. | 2009-12-31 |
20090324745 | COMPOSITIONS AND METHODS FOR NUTRITION SUPPLEMENTATION - The present invention relates to compositions, that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific embodiment, comprise vitamin B | 2009-12-31 |
20090324746 | SYSTEM FOR PRODUCING AND DISPENSING CHLORINE DIOXIDE - The invention relates to a multi-component chlorine dioxide producing system. The invention produces effective amounts of chlorine dioxide in five minutes or less without instantaneous production or loss of chlorine dioxide. The invention further includes a dispensing apparatus to allow for the dispensing of the multi component system to allow for insitu production of chlorine dioxide. | 2009-12-31 |
20090324747 | APPARATUS AND METHOD FOR MIXING A CONCENTRATED WATER TREATMENT SOLUTION - An apparatus includes a reservoir for holding a chemical solution, a pump and a discharge nozzle. The pump has an inlet and an outlet connected to the reservoir by inlet and discharge lines. The nozzle is disposed in a lower portion of the reservoir and discharges the solution toward the bottom of the reservoir; the nozzle has an inlet port connected to the pump discharge line through the sidewall of the reservoir. The pump inlet line is connected to a sidewall of the reservoir at a location below a normal surface level of the solution, and the pump discharge line is connected to the sidewall of the reservoir above that location. The reservoir, pump, pump inlet line, pump discharge line, nozzle inlet line and nozzle form a closed loop recirculation system effective to suspend insoluble material in the chemical solution. | 2009-12-31 |
20090324748 | TRAUMA THERAPY - The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic. | 2009-12-31 |
20090324749 | Ethanolic and/or Aqueous Composition of an Ammoniacal Solution of Alkaline Metal Salts of Azide, Mainly Sodium and Potassium - The present invention consists of the discovery about an ammoniacal solution of sodium azide (NaN | 2009-12-31 |
20090324750 | PHARMACEUTICAL COMPOSITION COMPRISING AN EXTRACT OF PSEUDOLYSIMACHION LONGIFOLIUM AND THE CATALPOL DERIVATIVES ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY - The present invention relates to a composition comprising an extract of | 2009-12-31 |
20090324751 | CHINESE HERB EXTRACT FOR TREATING DEMENTIA AND PREPARATION METHOD THEREOF - The present invention relates to a | 2009-12-31 |
20090324752 | COSMETIC USE OF ACTIVE INGREDIENTS INCREASING THE PRODUCTION OF GROWTH FACTORS - The invention relates to a cosmetic skin care method, intended to prevent and/or treat at least one cutaneous sign of ageing, including topical application to the skin of a composition containing at least one botanical active ingredient which increases the production by keratinocytes of at least one growth factor chosen from bFGF and PDGF. | 2009-12-31 |
20090324753 | Product and composition for alleviating post-menstrual symptoms - The current invention relates to a natural composition for topical application to skin to alleviate post-menstrual symptoms of cramping, backache, and breast tenderness; and for other aches and pains including Rheumatic, muscular and articular pains; and local treatment such as tendinitises, tennis elbow, benign distorsions, arthritis, osteoarthritis, neuralgia, sciatic nerve, lumbago, back pains, migraine, stiff neck, and insect bites. In one embodiment, the composition of the cream or lotion includes active natural ingredients of Carapa procera and Calotropis procera with shea butter and soy oil. In one embodiment the composition includes, by weight percent, 30% to 80% Butyrospermum parkii (Shea butter); 10% to 30% Glycine poja (soy); 10% to 30% Carapa procera; 3% to 10% Calotropis procera; and 3% to 10% Menthol. | 2009-12-31 |
20090324754 | EUCALYPTUS EXTRACT, METHOD OF PREPARATION AND THERAPEUTIC USES THEREOF - The present invention relates to the use of a | 2009-12-31 |
20090324755 | Method for the production of a plant-based medicament - A method for the production of a plant-based medicament which contains Iberis amara, Menthae piperitae folium, Matricariae flos, Carvi fructus, Melissae folium, Angelicae radix, Liquiritiae radix, Cardui mariae fructus and Chelidonii herba in the form of alcoholic extracts and a medicament produced according to this method, and its use. | 2009-12-31 |
20090324756 | Topical Preparations Comprising Flower Wax And Candelilla - The invention pertains to topical, wax-based compositions comprising one or more flower waxes and candelilla wax, in the ratio of about 20:1 to about 1:20. Such compositions may have improved shear resistance or be substantially plasticizer free. Stick-type and stay-in-place topical preparations are contemplated. | 2009-12-31 |
20090324757 | Compositions and Methods for Modulating Visceral Sensation and/or Gastrointestinal Reflex Activity - The invention relates to compositions capable of modulating visceral sensation and/or gastrointestinal activity obtained from botanical sources. More specifically, the invention relates to compositions comprising an extract product of an | 2009-12-31 |
20090324758 | PLANT EXTRACT MIXTURES AND THEIR USES - A composition comprising an effective amount of | 2009-12-31 |
20090324759 | IMMUNE ENHANCEMENT BY SEED OIL AND/OR SEED FLOUR - A method of treating a subject requiring immune mediation includes administering to the subject an immunostimulatory composition which contains black raspberry seed oil. Administering this composition stimulates the production of certain immune cells, including NK cells and CD8(+) lymphocytes. Administering the composition by this method also provides a method of treating, preventing, or ameliorating a condition or disease in the subject requiring enhanced immune system support. | 2009-12-31 |
20090324760 | Hair tonic - The present invention relates to hair tonic compositions containing acteoside of formula (I) | 2009-12-31 |
20090324761 | Methods And Compositions for Improving Gastrointestinal Health - Methods for maintaining or improving the gastrointestinal health of an animal by administering a gastrointestinal health maintaining or improving amount of at least one banana musa fruit to the animal susceptible to or suffering from poor gastrointestinal health. In one embodiment, banana is administered to the animal to prevent or treat diarrhea or to improve stool quality. In other embodiments, the banana musa fruit is administered in conjunction with one or more of foods, prebiotics, probiotics, and anti-diarrhea drugs. | 2009-12-31 |
20090324762 | MOLD CLAMPING DEVICE - A mold clamping device uses an electromagnet to generate clamping force. In the mold clamping device, a coil holding member holds a coil which constitutes a part of the electromagnet. A coil placement part is arranged in a surface of the coil holding member to place the coil therein, wherein the coil is embedded in the coil placement part by a molding material. The mold clamping device is able to cool the coil of the electromagnet appropriately. | 2009-12-31 |
20090324763 | Pressure Measurement Device and Mould for Vulcanizing Rubber for Tires | 2009-12-31 |
20090324764 | OPTICAL ELEMENT MOLDING APPARATUS - An optical element manufacturing apparatus is provided with a fixed side metal mold | 2009-12-31 |
20090324765 | Apparatus for the forming of a lay-up of fibre composite material - An apparatus for the forming of a lay-up of fibre composite material, in particular in the aerospace sector is provided. In this case, the apparatus has at least one forming tool, which has a surface contour corresponding to a desired geometry of the lay-up after the forming, and a tool carrier, to which the at least one forming tool is releasably fastened. From a further viewpoint, the invention makes available an apparatus with a modular structure, it then being possible for any desired forming tools to be combined with the tool carrier according to requirements. This leads in particular to less laborious handling, since it obviates the need for handling of the comparatively large tool carrier. | 2009-12-31 |
20090324766 | METHOD FOR FORMING MARK AND LIQUID EJECTION APPARATUS - A method for forming a mark includes ejecting a droplet of a liquid from a nozzle onto an ejection target position on a surface of an object along an ejecting direction; radiating a laser beam from a radiation port onto the ejection target position along a radiating direction; and pivoting the nozzle and the radiation port together about the ejection target position as a pivot center, thereby changing the angle between a normal line of the surface of the object and the ejecting direction and the angle between the normal line and the radiating direction while maintaining the angle between the ejecting direction and the radiating direction. | 2009-12-31 |
20090324767 | REPAIR TOOL FOR INJECTION MOLDING HOT RUNNER SYSTEM - A tool and method adapted to facilitate access to a hot runner system in an injection molding system wherein the hot runner system includes one or more injection nozzles projecting away from a hot runner surface. The tool includes a first plate structure having one or more nozzle acceptance openings adapted to engage the injection nozzles. A second plate structure is disposed in opposing, spaced apart relation from the first plate structure. One or more elongate spacers are disposed in connective spacing relation between the first plate structure and the second plate structure. | 2009-12-31 |
20090324768 | Spannschiene Fur Eine Membrane Einer Membranpresse - The invention describes a tensioning rail ( | 2009-12-31 |
20090324769 | LENS MOLD - A lens mold comprises a first pressing portion, a second pressing portion, and a shaping portion disposed between the two, which comprises an upper slide and a lower slide. The upper slide and the lower slide are connected to the second pressing portion, and can slide along each other. A mold cavity in fluidic communication with a flow path and the inlet such that the lens material flows from the inlet to the mold cavity along the flow path to form a shaped lens. After the lens is formed, the upper slide and the lower slide away from each other separately, where a part of the shaped lens is remains in a recess defined in the second pressing portion, to help release the shaped lens from the mold. | 2009-12-31 |
20090324770 | Bottom Insert With Heat Insulation - A bottom insert for a mold cavity for the production of moldings of plastic material. The mold cavity has a main body with a hot side which has a recess for receiving molten plastic material under pressure and a cold side having a recess, the inside contour of which is intended to come into contact with the molding to be produced and to shape the outside contour thereof. A gate ( | 2009-12-31 |
20090324771 | Modular injection molding hot runner system - An injection molding hot runner system of modular construction adapted for rapid removal and replacement during required maintenance. The system includes at least one hot runner module adapted for mounting at a support surface. The hot runner module includes one or more injection nozzles adapted for fluid communication with a supply of molten material and an arrangement of acceptance openings adapted to engage mounting projection elements extending away from the support surface | 2009-12-31 |
20090324772 | Methods and Apparatus for Atomization of a Liquid - Representative embodiments provide for corresponding fluid atomizer bodies, each generally defining a fluidicly communicative interior cavity. The interior cavity is typically defined by an entry passageway portion, a chamber portion, a plurality of feeder passageways that are tangentially disposed to and fluidly coupled with the chamber portion, and an exit passageway portion fluidly coupled to the chamber portion. In one embodiment, an upper body portion and a lower body portion are bonded together to define a complete fluid atomizer body. Another embodiment provides for producing one or more fluid atomizer bodies by a way of injection molding. | 2009-12-31 |
20090324773 | FREEZE-DRIED, DAIRY OR DAIRY-SUBSTITUTE COMPOSITIONS AND METHODS OF MAKING AND USING - The present invention comprises a freeze-dried, aerated dairy or dairy-substitute composition comprising a dairy or dairy-substitute ingredient and an emulsifier and methods of using and making thereof. | 2009-12-31 |
20090324774 | METHOD FOR FEEDING MOTHER PIG - An object of the present invention is to maintain good conditions of mother pigs and decrease the stillborn piglets and the death rate of piglets in breast-feeding period, so as to increase the productivity in pig farming. | 2009-12-31 |
20090324775 | METHOD OF PRODUCING A BRIGHT, YEAST FERMENTED BEVERAGE - The invention relates to a method of producing a bright, yeast fermented beverage, said method comprising the continuous production of wort from mash. More particularly, the present method comprises: a. mashing in a particulate, starch-containing raw material with water and enzymatically hydrolysing the starch to fermentable sugars; b. continuously producing a fermentable wort from the heated mash; c. introducing the wort into a fermenter to ferment the wort with the help of biologically active yeast; d. removing yeast from the fermentate by means of sedimentation; and e. clarifying the low-yeast fermentate to produce a bright, yeast fermented beverage by: processing the low-yeast fermentate in one or more separators to remove suspended material, said one or more separators being selected from the group consisting of centrifuges and decanter centrifuges; and filtering the processed fermentate. The efficiency with which the low-yeast fermentate is clarified to a bright beverage can be maintained during a very long period of time (e.g. for several weeks), which is particularly beneficial in case of a continuous brewing operation in which both wort production and yeast fermentation are carried out in a continuous fashion. | 2009-12-31 |
20090324777 | METHOD OF PRODUCING A PALATABILITY ENHANCER THAT CAN ADD HEALTH VALUE TO FOODSTUFFS - The present invention relates of a method of producing an enzymatic digest of proteinaceous material which can improve the palatability and health value of foodstuffs to which it is added. In particular but not exclusively, the invention involves a method where bioactive compounds are released to increase the health value of the product. | 2009-12-31 |
20090324778 | NOVEL PREPARATION OF PHOSPHODIESTERASE OF PLANT ORIGIN - The present invention relates to the preparation of a 5′-phosphodiesterase extracted from sorghum, and to its use for the preparation of a composition rich in 5′-nucleotides, in particular of a yeast extract. | 2009-12-31 |