Achyuta
Anilkumar H. Achyuta, Cambridge, MA US
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20150216682 | Array of Microelectrodes for Interfacing to Neurons within Fascicles - Methods and apparatus are disclosed for interfacing with nerve fibers, such as axons. Embodiments provide multiple micro-channels, into which individual fascicles of a nerve may be placed, one fascicle per micro-channel. Each micro-channel has an associated set of micro-wire electrodes that penetrate the fascicle in the micro-channel. The micro-wire electrodes are thinner than prior art photolithographed micro-electrode arrays. Consequently, more micro-wire electrodes may interface with a single fascicle, and each micro-wire electrode interfaces with fewer axons, than in the prior art. Multiple rows of micro-channels may be stacked to construct two-dimensional arrays of micro-channels. These embodiments thereby facilitate finer motor control in prosthetic devices, and more granular sensory feedback from prosthetic devices to central nervous systems, than is achievable in the prior art. | 08-06-2015 |
20150217109 | Multi-Layered Micro-Channel Electrode Array with Regenerative Selectivity - A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels. | 08-06-2015 |
Anilkumar Harapanahalli Achyuta, Tampa, FL US
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20140030752 | MODULAR PLATFORM FOR MULTI-TISSUE INTEGRATED CELL CULTURE - The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. By culturing organ specific tissue types within a biomimetic environment and interconnecting each of the organ systems in a physiologically meaningful way, experiments can be conducted on in vitro cells that substantially mimic the responses of in vivo cell populations. In some implementations, the system is used to monitor how organ systems respond to agents such as toxins or medications. The system enables the precise and controlled delivery of these agents, which, in some implementations, enables the biomimetic dosing of drugs in humans to be mimicked. | 01-30-2014 |
Anilkumar Harapanahalli Achyuta, Cambridge, MA US
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20130203086 | MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS - This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels. | 08-08-2013 |
20150140581 | MICROFLUIDIC DEVICE FOR GENERATING NEURAL CELLS TO SIMULATE POST-STROKE CONDITIONS - This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other side of the barrier run one or more fluid-filled channels. By flowing fluid with different oxygen levels through the channels, one can deliver desired oxygen concentrations to the cells nearest those channels. | 05-21-2015 |
Venkata Kumar Achyuta, Santa Clara, CA US
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20120293465 | SOLUTION FOR LOCATION BASED NOTIFICATION OF INTELLIGENT DISCOVERY APPLICATION TO USER - In accordance with an example embodiment, there is disclosed herein an apparatus including a processor, a data storage in data communication with the processor, a display, a wireless data transceiver, and a display driver. The data storage is operable for storage of application programs and application data. Identification data is disposed in the data storage, wherein the identification data is uniquely associated with the wireless data transceiver. The wireless data transceiver is operable to broadcast the identification data to at least one associated wireless access point having a predefined location relative to an associated premises prior to establishing a networked data connection therewith, and is further operable to receive notification data, responsive to broadcast identification data, from an associated networked data server. The display driver is operative to display data corresponding to the received notification data on the display. | 11-22-2012 |