Alfonso, US
Berenice Alfonso, Fairfax, VA US
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20140349285 | POLYMERASE DRIVEN NESA - The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising (a) exposing the target polynucleotide to an initiating oligonucleotide; (b) extending the initiating oligonucleotide with an extended sequence complementary to the target sequence; (c) ligating the initiating oligonucleotide sequence with the extended sequence to form a circular oligonucleotide having a nicking endonuclease (NE) recognition/cutting sequence; (d) exposing the circular oligonucleotide to a DNA polymerase and a DNA synthesis primer to synthesize DNA having a NE recognition sequence; (e) exposing the synthesized DNA to a probe having the NE recognition/cutting sequence to form a double stranded DNA having a full NE site; (f) exposing the double stranded DNA to a nicking endonuclease (NE) to cleave the probe; and (g) detecting the cleaved probe. The presence of the cleaved probe indicates the presence of the target polynucleotide. | 11-27-2014 |
20140349286 | EXONUCLEASE CYCLING ASSAY - The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising hybridizing the target polynucleotide with a probe to form a hybrid; exposing the hybrid to a 5′ exonuclease so that the probe in the hybrid is digested and the target polynucleotide is dissociated from the digested probe; repeating the hybridization step and the digestion step; and detecting the digested probes. The presence of the digested probes indicates the presence of the target polynucleotide. | 11-27-2014 |
Chris Alfonso, Raleigh, NC US
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20150242197 | Automatic Installing and Scaling of Application Resources in a Multi-Tenant Platform-as-a-Service (PaaS) System - A mechanism for automatic installing and scaling of application resources in a multi-tenant Platform-as-a-Service (PaaS) environment in a cloud computing system is disclosed. A method includes creating, by a processing device of an Infrastructure-as-a-Service (IaaS) platform, an image package corresponding to a node host on a multi-tenant Platform-as-a-Service (PaaS) system. The image package comprises an image file including a script file having a plurality of software updates and run time configuration files. The image package is stored in a storage memory of the IaaS platform and is accessible by a virtual machine (VM) instance. The method also includes retrieving, from the storage memory, the script file from the image package and causing a boot process of the VM instance to download the script file into the PaaS system. | 08-27-2015 |
Chris Alfonso, Mt. Pleasant, SC US
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20110106607 | Techniques For Targeted Offers - Systems and methods for analyzing and segregating payment card account profiles into clusters and targeting offers to cardholders. Offers may be targeted based on analyzing customer transactions with merchants from a merchant category as compared with transactions with merchants from a universe of merchants. Customers who have no transaction history with a merchant may be selected for offers based on similarities with respect to other customers of the merchant. Multiple merchant offers may be combined into a single mailing based on a scoring algorithm. | 05-05-2011 |
Christopher Alfonso, Raieigh, NC US
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20090300619 | Product independent orchestration tool - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. A configuration management tool is configured to orchestrate and automate a deployment process, and to interface with an underlying product having a corresponding functionality. | 12-03-2009 |
Christopher Alfonso, Raleigh, NC US
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20090300609 | Combining system blueprints, functional layer, and software bits in parallel development of machines - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. A source code management tool stored in the distributable self-contained repository is configured to develop each virtual machine independently from each other in parallel, and to merge back the developments to a corresponding parent virtual machine. | 12-03-2009 |
20090300610 | Self-replicating machines - A self-replicating machine includes a virtualization tool, a provisioning tool, and a configuration tool, stored in a distributable self-contained repository of the machine. The machine is able to automatically rebuild itself solely from the tools stored in the distributable self-contained repository. The virtualization tool is configured to build one or more virtual machines on the machine. Each virtual machine has a corresponding operating system and environment. The provisioning tool is configured to provision the one or more virtual machines. The configuration tool is to configure the one or more provisioned virtual machines. A custom configuration management tool further customize and configure the physical machine for specific users. | 12-03-2009 |
Driany F. Alfonso, Surfside, FL US
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20140243901 | Dynamic Compression Plate - A system, devices and methods are provided for facilitating stabilization of periarticular fractures. The system includes a compression plate and one or more of a cerclage cable for encircling the bone and securing the compression plate to the bone, a crimp lug for securing the cable in tension relative to the bone and/or a plate, and a supplemental plate coupled to the compression plate and adapted to receive bicortical or unicortical bone screws to further secure the compression plate relative to the bone. In addition, the system includes a cable tensioner for temporarily retaining the cable in tension and then applying a tension to the cable until a desired compression is effected between a plate and bone and while a cable retaining structure is secured to the cable to retain the applied tension on the cable. Also provided is a jig for use with plates for minimally invasive fracture stabilization. | 08-28-2014 |
20150142064 | Plate Benders and System - A pair of plate benders is provided for bending a bone plate having a plurality of screw holes and a plurality of tubular drill guides removably preassembled into the screw holes. Each plate bender has a first end, a second end, and a handle extending between the first and second ends. The first end has a lower table on which the plate is received, an upper retaining structure which is adapted to engage the tubular drill guides, a recess defined between the lower table and upper retaining structure into which a portion of the plate is received such that the plate extends over a portion of the table and below a portion of the retaining structure. The retaining structure engages the periphery of the tubular drill guides to secure the plate relative to the bending tool. | 05-21-2015 |
Edward Alfonso, Riverside, CA US
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20110230841 | User wearable device for carrying peritoneal dialysis catheter - My invention discloses an easily wearable catheter. A housing secures the components of the catheter, i.e. the valve, the removable cap, the twist valve, and the hose, to the user by means of an attachment. The present invention relates generally to continuous ambulatory peritoneal dialysis methods and systems and, more particularly, to a user-wearable catheter housing which does not require any tape, belt or other bulky retainer to keep the catheter attached to the user. | 09-22-2011 |
20150105730 | USER WEARABLE DEVICE FOR CARRYING PERITONEAL DIALYSIS CATHETER - Improvements in an easily wearable catheter. A housing secures the components of the catheter, i.e. the valve, the removable cap, the twist valve, and the hose, to the user by means of an attachment. The present retainer for a peritoneal dialysis catheter relates generally to continuous ambulatory peritoneal dialysis methods and systems and, more particularly, to a user-wearable catheter housing which does not require any tape, belt or other bulky retainer to keep the catheter attached to the user. | 04-16-2015 |
James Alfonso, Palm Beach Gardens, FL US
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20150128609 | TRANSITION SUPPORT SYSTEM FOR COMBUSTION TRANSITION DUCTS FOR TURBINE ENGINES - An adjustable transition duct support system for a transition duct that channels hot gases from a combustor exit to a gas turbine inlet of a turbine engine. The adjustable transition duct support system includes an adjustable forward transition flexible support assembly in contact with a transition duct body, whereby the forward transition flexible support assembly may be formed from a base extending toward the transition duct body and first and second side support arms extending from the base to the transition duct body. The first and second side support arms may be formed from a plurality of flex plates spaced from each other with spacers that provide rigidity in circumferential and radial directions and flexibility in an axial direction. The number of flex plates used may be varied to accommodate different turbine engines. The adjustable transition duct support system may have natural frequencies for circumferential and radial modes above two engine orders. | 05-14-2015 |
Jesus Jose Alfonso, Trinity, FL US
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20140054945 | Headrest System - Disclosed is an infant's headrest system that is adapted to be secured to a car seat, booster seat, or high chair. The headrest includes two halves that can be independently secured to the seat and that can be joined to one another via hook and pile fasteners. The two ends can be brought together around the periphery of an infant's head to prevent the infant's head from bobbing forward while they are asleep. | 02-27-2014 |
Jorge Alfonso, Orlando, FL US
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20140108222 | Rules engine having user activated rules of selectable scope and selectable outcomes - Orders for execution of securities transactions and requests for asset movement are screened by a rules engine and may be automatically approved. The rules engine has rules which are user configurable. The rules may be configured to provide different outcomes, to provide a user selectable scope of application and to provide user selectable parameters. A transaction is processed against the rule set applicable thereto in order of increasing scope of the rules. That is, rules applicable to the account level are processed before rules applicable to the registered representative, office or firm. Individual broker-dealer firms may each configure rules applicable to their own firms independently of rules applicable to any other firm serviced by the rules engine. | 04-17-2014 |
Jorge R. Alfonso, Austin, TX US
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20110214381 | SUPPORTING REBAR WITH INTERCHANGEABLE CROWNS - A support structure for retaining a reinforcing bar (“rebar”). Such a structure includes a rebar engaging portion, where the rebar engaging portion includes a receptacle. The receptacle includes a channel sized to receive the rebar, where the channel includes a first portion and a bar retaining portion defined by sidewalls that extend radially outward from a first end to a second end. The retaining features are disposed on the walls of the channel, where the sidewalls are configured to spread so that the rebar passes the retaining features and rests in the bar retaining portion as the rebar moves down the channel. Additionally, the support structure includes a support portion supporting the rebar engaging portion, where the support portion includes a plurality of legs which project outward from a central axis. In addition, the support structure includes a base configured to distribute weight of the support structure. | 09-08-2011 |
20110214382 | REBAR SUPPORT CHAIR - A chair for supporting one or more bars. The chair can include a base, a lateral cross member and legs to support the lateral cross-member a distance away from the base. The lateral cross member can include one or more receptacles to receive the bar. Each receptacle can have a set of sidewalls defining an opening to a side of the lateral cross member (e.g., the top side). The lateral cross-member can be configured to allow the sidewalls to spread apart laterally so that the opening can widen to receive a bar. The lateral-cross member can be formed of a resilient material so that the opening closes to have a width less than that of the bar when the bar is in a bar retaining area. The lateral cross-member can include multiple bar receptacles to retain parallel bars. The bar receptacles can act as snap-fits. | 09-08-2011 |
20120247057 | REBAR SUPPORT RINGS - Structures for supporting and aligning a reinforcing bar (“rebar”) during the construction of a column, beam or other structure in which the rebar is laid out in parallel to an axis. One such structure includes a support structure having a square ring, where the corners of the square ring include a rebar receptacle configured to receive a reinforcing bar. The rebar receptacle includes an opening through which the reinforcing bar can be inserted, where the opening is configured to allow the reinforcing bar to enter the rebar receptacle and further configured to retain the reinforcing bar after the reinforcing bar has been seated due to the width of the opening being less than a diameter of the reinforcing bar. | 10-04-2012 |
20120247058 | SUPPORTING MULTIPLE MATS - A support structure for retaining a reinforcing bar (“rebar”) in stacked layers. Such a structure includes a first support structure retaining a first rebar for a first mat. The support structure further includes a second support structure retaining a second rebar for a second mat. The first support structure and the second support structure can have similar configurations. The second support structure includes a first layer engaging portion, a second layer engaging portion and a support portion for connecting said engaging portions. The second layer engaging portion may include a reinforcing receptacle which includes a channel open to receive a rebar. The channel is defined by sidewalls that extend radially outward from an inner end receptacle. The sidewalls spread so that the rebar can pass retaining features on the walls of the channel and rest in a bar retaining portion as the rebar moves down the channel. | 10-04-2012 |
Juan Alfonso, Hopewell Junction, NY US
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20090111923 | Halo-functional silane, process for its preparation, rubber composition containing same and articles manufactured therefrom - A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality. | 04-30-2009 |
20100036018 | ACTIVATED HALO-CONTAINING ARALKYLSILANE COMPOSITION, PROCESS OF PREPARING SAME AND RUBBER COMPOSITIONS MADE THEREFROM - The invention is directed to an activated halo-containing aralkylsilanes possessing at least one hydrolyzable group bonded to a silicon atom and at least one halo functional group bonded to a carbon atom to which both the silicon atom and an aromatic group are covalently bonded. The invention is also directed to a process for making such a silane as well as its use in rubber compositions and articles containing such rubber compositions, such as tires. | 02-11-2010 |
20110003922 | Halo-Functional Silane, Process For Its Preparation, Rubber Composition Containing Same and Articles Manufactured Therefrom - A halo-functional silane possesses halogen functionality and alkanedioxysilyl functionality. | 01-06-2011 |
Krystal R. Alfonso, San Jose, CA US
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20150325401 | LOW-DOSE RADIOGRAPHIC IMAGING SYSTEM - An inspection system for scanning cargo and vehicles is described which employs an X-ray source that includes an electron beam generator, for generating an electron beam; an accelerator for accelerating said electron beam in a first direction; and, a first set of magnetic elements for transporting said electron beam into a magnetic field created by a second set of magnetic elements, wherein the magnetic field created by said second set of magnetic elements causes said electron beam to strike a target such that the target substantially only generates X-rays focused toward a high density section in the scanned object, which is estimated in a second pulse using image data captured by a detector array in a first pulse. The electron beam direction is optimized by said X-ray source during said second pulse to focus X-rays towards said high density section based on said image data in said first pulse. | 11-12-2015 |
Lazaro Alfonso, Miami, FL US
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20100089220 | MULTI FREQUENCY MERGER MUSIC DEVICE - A music device comprising a large acoustic frequency chamber, the chamber further comprising an elastic membrane placed on the acoustic chamber. It also comprises, at least one tightening ring and one tightening tuning device, where the tightening tuning device is anchored to a tightening ring and an elastic membrane. The device further comprises one small acoustic frequency chamber that contains another elastic membrane and a second tightening ring. Both chambers combine acoustic frequencies to produce a single combined acoustic frequency. The music tuning device is used both to clasp at least one drum skin and to mask unharmonic resonances. | 04-15-2010 |
Mark Alfonso, Easton, CT US
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20080262284 | DISPOSAL SYSTEM FOR TRANSDERMAL DOSAGE FORM - The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. | 10-23-2008 |
20150182474 | DISPOSAL SYSTEM FOR TRANSDERMAL DOSAGE FORM - The present invention relates to a disposable article to prevent the misuse of a transdermal dosage form (FIG. | 07-02-2015 |
Mark A. Alfonso, Easton, CT US
Noel Alfonso, Chandler, AZ US
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20140278615 | MISCONNECT MANAGEMENT SYSTEMS AND METHODS - A misconnect management system models the movement of passengers, bags, and crew through flights and airports. In various embodiments, a misconnect management system identifies potential misconnected passengers and provides recommendations and input configured to support decision makers, such as ramp controllers and operations controller, in evaluating hold/no hold decisions for a flight. Via use of the misconnect management system and associated methods, misconnected passenger numbers may be reduced, expenses associated with missed connections may be reduced, and organizational efficiency may be improved. | 09-18-2014 |
Pedro Alfonso, Malvern, PA US
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20090171072 | Process for Preparing Unaggregated Antibody FC Domains - Methods useful for producing a solution of purified Fc peptide chains are disclosed. The methods employ protein A chromatography to separate high molecular weight, aggregated peptide chains comprising antibody Fc domains from lower molecular weight unaggregated peptide chains that also comprise antibody Fc domains. The solutions of purified Fc peptide chains obtained by the methods of the invention contain less than 5% aggregate and greater than 70% of the Fc peptide chains subjected to purification. | 07-02-2009 |
Pedro Alfonso, East Lyme, CT US
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20090062510 | Human Chemotactic Cytokine I Polypeptides - Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host. | 03-05-2009 |
Pedro M. Alfonso, Austin, TX US
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20090119963 | Information Handling System Product Badge Orientation System and Method - A product badge coupled to a product, such as an information handling system, has a manually-selectable orientation to allow the orientation of the product badge to change for adapting to changes in the orientation of the product. A product badge support rotationally couples the product badge to the product for user selection of a desired orientation of product information, such as a manufacturer logo or a product identification number. Manual activation to change product badge orientation includes pushing the product badge into the product badge support to engage opposing cams, pushing the product badge edge to rotate the product badge to an opposing side having product information of another orientation, and pushing the product badge to activate a retention mechanism for release and retention of a selected of plural clips. | 05-14-2009 |
Robert Alfonso, Miami, FL US
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20110031373 | ELECTRONIC DISPLAY MOUNT - The invention is a mount for an electronic display device. The mount comprises a mount member that has a top face and a bottom face. Portions of the mount member are configured to engage portions of a mounting surface within the cockpit of an airplane. The mount also comprises a containment member spaced therefrom the mount member. A joint member is disposed in frictional contact with portions of the respective mount member and containment member. A base member, which can be configured for engagement with a portion of the electronic display device, can be connected to the joint member. | 02-10-2011 |
Rosario Ramil C. Alfonso, Ashburn, VA US
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20150354964 | Mission Planning System and Method - A system and method for planning missions is provided. The system includes at least one client computer coupled to a network, and a server, coupled to the network, that includes a processor coupled to a memory storing instructions that, when executed by the processor, perform a method for planning missions that includes providing a graphical user interface (GUI) to the client computer, creating a mission including a plan, updating the plan and providing the updated plan to the client computer. | 12-10-2015 |
Yerko Alfonso, Covina, CA US
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20090033341 | CAPACITIVE TACTILE TILE SENSOR - A capacitive tile tactile sensor is described and includes several groups of individual sensors each controlled by a dedicated IC. Individual sensors are formed by sensing electrodes on one side of the sensor and a single ground electrode on the other side, the ground electrode is separated from the sensing electrodes by a compressible dielectric layer. A single electrical connection between the ground electrode and the sensing electrode layer allows for routing of all electrical connections including individual electrodes and a ground electrode to appropriate ICs within the same layer using conductive ink or other similar techniques. Stand-alone configurations are described as well as those adapted for communicating with outside control means including a personal computer. Arranging groups of sensors in parallel with each other creates a matrix of sensors while arranging them along a single line creates a linear strip sensor. Using off-the-shelf capacitance-sensing ICs to control a limited number of capacitance sensors allows reducing the number of electrical connections to the sensor array and increasing its reliability. | 02-05-2009 |
Zeni Alfonso, Temecula, CA US
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20110206646 | METHODS OF USING ADIPOSE TISSUE-DERIVED CELLS IN THE TREATMENT OF THE LYMPHATIC SYSTEM AND MALIGNANT DISEASE - Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and/or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration. | 08-25-2011 |
20140369970 | METHODS OF USING ADIPOSE TISSUE-DERIVED CELLS IN THE TREATMENT OF THE LYMPHATIC SYSTEM AND MALIGNANT DISEASE - Aspects of the invention provides methods for preparing and using adipose-tissue-derived stem and progenitor cells, adipose-tissue-derived lymphatic endothelial cells, and cells capable of differentiating into lymphatic endothelial cells to treat disorders of the lymphatic system and to modulate expansion, repair, and/or regeneration of the lymphatic system. The invention further provides using adipose-tissue-derived lymphatic endothelial cells and cells capable of differentiating into lymphatic endothelial cells for delivery of therapeutic agents to tumor cells as a means for treating malignant disease, and assays to screen for drugs that modulate lymphatic system expansion, repair or regeneration. | 12-18-2014 |