Patent application number | Description | Published |
20120045771 | METHOD FOR ANALYSIS OF NUCLEIC ACID POPULATIONS - The invention relates to a method for isolation of target molecules from a nucleic acid population. | 02-23-2012 |
20120108462 | MIRNA FINGERPRINT IN THE DIAGNOSIS OF LUNG CANCER - The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls. | 05-03-2012 |
20120157336 | miRNA FINGERPRINT IN THE DIAGNOSIS OF DISEASES - The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 06-21-2012 |
20120157337 | miRNA FINGERPRINT IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS - The present invention provides novel methods for diagnosing diseases based on the determination of specific miR-NAs that have altered expression levels in disease states compared to healthy controls. | 06-21-2012 |
20120309645 | miRNA IN THE DIAGNOSIS OF OVARIAN CANCER - The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 12-06-2012 |
20130035251 | miRNA FINGERPRINT IN THE DIAGNOSIS OF WILMS' TUMOUR - MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 02-07-2013 |
20130245958 | ACCURATE COMPARISON AND VALIDATION OF SINGLE NUCLEOTIDE VARIANTS - A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest. | 09-19-2013 |
20140058752 | COMPUTER NETWORK FOR QUALITY TESTING CLINICAL TRIAL DATA - A computer network system and a method for quality testing input clinical trial data are disclosed. The trial data is recorded by way of a form provided on a patient device or a physician device and is passed on in an encrypted, anonymized form to a central server. A quality testing device is installed on the server in order to test the recorded medical data sets with regard to the quality thereof. The scope of the quality test is configurable. In the event of successful testing, an incentive attribute is read out from a database in order to generate an incentive signal and to transmit the signal to the respective terminal device. | 02-27-2014 |
20150031777 | miRNA FINGERPRINT IN THE DIAGNOSIS OF WILMS' TUMOUR - MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 01-29-2015 |
20150292020 | miRNA Fingerprint in the Diagnosis of COPD - MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 10-15-2015 |
20150337393 | miRNA FINGERPRINT IN THE DIAGNOSIS OF PROSTATE CANCER - MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing prostate cancer based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls | 11-26-2015 |
20160053325 | miRNA FINGERPRINT IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS - The present invention provides novel methods for diagnosing diseases based on the determination of specific miRNAs that have altered expression levels in disease states compared to healthy controls. | 02-25-2016 |
20160076103 | miRNA FINGERPRINT IN THE DIAGNOSIS OF DISEASES - The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls. | 03-17-2016 |
Patent application number | Description | Published |
20130157883 | Complex miRNA Sets as Novel Biomarkers for an Acute Coronary Syndrome - The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference. | 06-20-2013 |
20130331278 | COMPLEX SET OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR PROSTATE DISEASES - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of prostate diseases in a body fluid sample from a subject. | 12-12-2013 |
20130331290 | COMPLEX MIRNA SETS AS NOVEL BIOMARKERS FOR LUNG DISEASES - The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of a lung disease in a biological sample from a patient. Further, the present invention relates to means for diagnosing and/or prognosing of a lung disease comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of a lung disease based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for a lung disease. In addition, the present invention relates to a kit for diagnosing and/or prognosing of a lung disease comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for a lung disease and optionally at least one reference and/or algorithm or mathematical function comprised on at least one data carrier. | 12-12-2013 |
20140012558 | SYSTEM AND METHODS FOR INTEGRATED AND PREDICTIVE ANALYSIS OF MOLECULAR, IMAGING, AND CLINICAL DATA FOR PATIENT-SPECIFIC MANAGEMENT OF DISEASES - A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode. | 01-09-2014 |
20140024554 | COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR GLIOBLASTOMA - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of glioblastoma in a body fluid sample from a subject. | 01-23-2014 |
20140194312 | COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR DILATED CARDIOMYOPATHY - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of dilated cardiomyopathy in a body fluid sample from a subject. | 07-10-2014 |
20140213476 | COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR COLON CANCER - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of colon cancer in a body fluid sample from a subject. | 07-31-2014 |
20140274789 | COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR PSORIASIS - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. In addition, the present invention relates to sets of miRNAs for diagnosing and/or prognosing of psoriasis in a body fluid sample from a subject. | 09-18-2014 |
20150037327 | miRNA based treatment monitoring in multiple sclerosis - The present invention relates to methods of determining whether a patient responds to a therapeutic treatment of multiple sclerosis (MS), of monitoring the course of multiple sclerosis (MS) in a patient, of determining the risk for a relapse of multiple sclerosis (MS) in a patient, and of adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient. Said methods are based on the determination of the level of at least one miRNA in a test sample isolated from the patient. The present invention also relates to a method of identifying a compound suitable for the treatment of multiple sclerosis in a patient. Further, the present invention relates to the use of a polynucleotide or a polynucleotide set for detecting a miRNA to determine whether a patient responds to a therapeutic treatment of multiple sclerosis, to monitor the course of multiple sclerosis in a patient, to determine the risk of a relapse of multiple sclerosis in a patient, to adjust the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, and to identify a compound suitable for the treatment of multiple sclerosis in a patient. Furthermore, the present invention relates to a kit for determining whether a patient responds to a therapeutic treatment of multiple sclerosis, for monitoring the course of multiple sclerosis in a patient, for determining the risk of a relapse of multiple sclerosis in a patient, for adjusting the dose of a therapeutic drug applied for therapeutic treatment of multiple sclerosis in a patient, or for identifying a compound suitable for the treatment of multiple sclerosis in a patient comprising means for determining the level of at least one miRNA in a test sample isolated from a patient. | 02-05-2015 |
20150037797 | IMMUNOASSAY FOR DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES SUCH AS MIRNAS - The invention relates to a method of detecting nucleic acid molecules by immunoassay detection. Detection of a specific nucleic acid molecule of interest is achieved by using a nucleic acid probe in solution which hybridizes in solution to the nucleic acid molecule of interest. Immunoassay detection is achieved by using an antibody specific for the hybrid formed by hybridization of the nucleic acid probe to the nucleic acid molecule of interest. | 02-05-2015 |
20150045243 | MIRNAS AS NON-INVASIVE BIOMARKERS FOR DIAGNOSIS - The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of a disease in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of a disease in a body fluid sample from a subject. | 02-12-2015 |
20150064704 | COMPLEX SETS OF MIRNAS AS NON-INVASIVE BIOMARKERS FOR EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION - The present invention relates to non-invasive methods for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject. Further, the present invention relates to polynucleotides or sets of polynucleotides for detecting miRNAs or sets of miRNAs for early diagnosis and/or differential diagnosis of acute myocardial infarction in a blood sample of a subject. | 03-05-2015 |
20150111772 | DIAGNOSTIC MIRNA PROFILES IN MULTIPLE SCLEROSIS - The invention relates to methods for diagnosing multiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS. | 04-23-2015 |
20150184223 | METHOD FOR IMPROVED QUANTIFICATION OF MIRNAS - The invention relates to a method and kit for enriching miRNA nucleic acids molecules of interest in a sampe by selective removal of nucleic acid species, in particular miRNA species, which are not of interest. The invention is based on the surprizing and previously unknown information that only a few individual miRNA species make up the majority of all miRNA species in a sample. Selective removal of these species prior to detection of miRNA nucleic acids molecules will improve assay time, assay sensitivity, and reproducibility. | 07-02-2015 |
20150292013 | NOVEL MIRNAS AS DIAGNOSTIC MARKERS - The invention relates to novel miRNA markers useful for diagnosis or therapy of disease, in particular for neuronal disorders such as Alzheimer's Disease (AD). | 10-15-2015 |
20150315641 | NEW DIAGNOSTIC MIRNA MARKERS FOR PARKINSON DISEASE - The invention relates to methods for diagnosing Parkinson's Disease PAD) with miRNA markers. Towards the identification of biomarkers for diagnosis of PD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified. | 11-05-2015 |