Patent application number | Description | Published |
20090295613 | PERFORMING ANALOG-TO-DIGITAL CONVERSION BY COMPUTING DELAY TIME BETWEEN TRAVELING WAVES IN TRANSMISSION LINES - A method and device for converting an analog input electrical signal to a digital signal. A plurality of integrated active and/or passive transmission lines may be implemented with signal-dependant propagation velocities. The delay differences of pulses traveling through these transmission lines are compared, and the collective results are used to evaluate and subsequently quantize the input signal. | 12-03-2009 |
20100122904 | INCORPORATING CMOS INTEGRATED CIRCUITS IN THE DESIGN OF AFFINITY-BASED BIOSENSOR SYSTEMS - A biosensor system incorporating CMOS integrated circuits. In one type of biosensor system, the biosensor system includes a complementary metal-oxide-semiconductor (“CMOS”) integrated circuit. The biosensor system further includes an optical filter fabricated on the CMOS integrated circuit. Additionally, a plurality of capturing probes is optically coupled to the CMOS integrated circuit. Alternatively, another type of biosensor system includes a silicon substrate. The alternative biosensor system further includes active devices fabricated on the silicon substrate. Additionally, the alternative biosensor system includes a plurality of metal layers stacked on top of the active devices. Furthermore, the alternative biosensor system includes a passivation layer covering a top metal layer, where the passivation layer includes an opening configured to expose the top metal layer, where the opening is used as a sensing electrode. Additionally, the alternative biosensor system includes a plurality of probes attached to the sensing electrode. | 05-20-2010 |
20120077692 | MULTIPLEX Q-PCR ARRAYS - This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. | 03-29-2012 |
20120168306 | INCORPORATING CMOS INTEGRATED CIRCUITS IN THE DESIGN OF AFFINITY-BASED BIOSENSOR SYSTEMS - A biosensor system incorporating CMOS integrated circuits. In one type of biosensor system, the biosensor system includes a silicon substrate. The biosensor system further includes active devices fabricated on the silicon substrate. Additionally, the biosensor system includes a plurality of metal layers stacked on top of the active devices. Furthermore, the biosensor system includes a passivation layer covering a top metal layer, where the passivation layer includes an opening configured to expose the top metal layer, where the opening is used as a sensing electrode. Additionally, the biosensor system includes a plurality of probes attached to the sensing electrode. | 07-05-2012 |
20130134546 | HIGH DENSITY MULTI-ELECTRODE ARRAY - A method includes forming one or more trenches in a substrate; lining the one or more trenches with a dielectric liner; filling the one or more trenches with a conductive electrode to form one or more trench electrodes; forming a transistor layer on the substrate; connecting each of the one or more trench electrodes to at least one access transistor in the transistor layer; and thinning the substrate to expose at least a portion of each of the trench electrodes. | 05-30-2013 |
20130187253 | HIGH DENSITY MULTI-ELECTRODE ARRAY - A high density micro-electrode array includes a transistor layer including a plurality of access transistors and a substrate in operable communication with the transistor layer including, wherein at least a portion of the substrate includes a plurality of trenches. The system includes a plurality of electrodes at least partially located in the plurality of trenches, wherein each of the plurality of electrodes is connected to at least one of the plurality of access transistors and wherein each of the electrodes is separated by a distance less than approximately one microns. | 07-25-2013 |
20130345065 | ACTIVE-ELECTRODE INTEGRATED BIOSENSOR ARRAY AND METHODS FOR USE THEREOF - A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized. | 12-26-2013 |
20140001341 | INTEGRATED OPTICAL BIOSENSOR ARRAY | 01-02-2014 |
20140011710 | ACTIVE-ELECTRODE INTEGRATED BIOSENSOR ARRAY AND METHODS FOR USE THEREOF - A method and device for performing DNA sequencing and extracting structural information from unknown nucleic acid strands. The device includes a microwell structure, where identical DNA strands are immobilized within the microwell structure on a surface of a micro-bead, an active electrode or a porous polymer. The device further includes a CMOS-integrated semiconductor integrated circuit, where the CMOS-integrated semiconductor integrated circuit includes metal layers on a silicon substrate, where the metal layers form an active electrode biosensor. In addition, a sensing electrode is formed by creating openings in a passivation layer of the CMOS-integrated semiconductor integrated circuit to hold a single bead, on which the DNA strands are immobilized. | 01-09-2014 |
20140318958 | INTEGRATED ELECTRO-ANALYTICAL BIOSENSOR ARRAY - A biosensor pixel for measuring current that flows through the electrode surface in response to electrochemical interactions and a biosensor array architecture that includes such biosensor pixels. The biosensor pixel includes an electrode transducer configured to measure a current generated by electrochemical interactions occurring at a recognition layer placed directly on top of it in response to an electrical voltage placed across an electrode transducer-electrolyte interface. The biosensor pixel further includes a trans-impedance amplifier connected to the electrode transducer, where the trans-impedance amplifier is configured to convert the current into a voltage signal as the electrochemical interactions occur. Additionally, the biosensor pixel includes a 1-bit comparator coupled to the trans-impedance amplifier and a 1-bit digital-to-analog converter coupled to the 1-bit comparator, where the 1-bit digital-to-analog converter injects different levels of charge into an input of the trans-impedance amplifier at each cycle based on an output of the 1-bit comparator. | 10-30-2014 |