Beachy, US
Dawn E. Beachy, Gainesville, FL US
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20130315974 | Non-Hormonal Female Contraceptive - Disclosed herein are compositions and methods for controlling fertility of a female subject. Particularly exemplified are compositions comprising sugar derivatives, such as 2-deoxyglucose, D-mannoheptulose; and/or 5-thio-D-glucose. Also disclosed herein are methods of preserving ova supply in a female subject that involves administering glucose derivatives. The composition typically includes a glucose derivative that affects Foxo3a expression. | 11-28-2013 |
Lloyd Beachy, Nappanee, IN US
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20150021384 | Mailbox Alert System - A mail alert, signaling device for use with a mailbox having a housing and door for receiving mail said device being attached at one of its ends to the exterior of the mailbox and having a signaling portion on the other end wherein an L-shaped member of the signaling portion reversibly couples with a lip portion on the mailbox to configure the device in standby mode, and when the door is opened die L-shaped member is dislodged from the lip portion thereby signaling mail delivery. | 01-22-2015 |
Marvin E. Beachy, Grantsville, MD US
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20110272211 | PAINT ROLLER TRAY MOUNTING DEVICE - A paint roller tray mounting device includes a platform that has a width sized to fit between first and second side rung supports of a ladder, a length sufficient to support a paint roller tray. The platform has a recess in an upper surface sized and shaped to provide a gripping surface for a ladder rung. At least two securing hooks have a hooking end and an attaching end. The hooks are symmetrically attached at the attaching end adjacent opposite edges of the platform. The hooks extend from at least a lower surface of the platform to a surrounding upper edge of the paint roller tray. The hooks have a tightening device for urging the tray and the platform together. The platform is located beneath the ladder rung or a top shelf of a step ladder. The paint roller tray is located above either the rung or the top shelf. | 11-10-2011 |
Marvin E. Beachy, Gransville, MD US
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20150211299 | PAINT ROLLER TRAY MOUNTING DEVICE - A paint roller tray mounting device includes a platform that has a width sized to fit between first and second side rung supports of a ladder, a length sufficient to support a paint roller tray. The platform has a recess in an upper surface sized and shaped to provide a gripping surface for a ladder rung. At least two securing hooks have a hooking end and an attaching end. The hooks are symmetrically attached at the attaching end adjacent opposite edges of the platform. The hooks extend from at least a lower surface of the platform to a surrounding upper edge of the paint roller tray. The hooks have a tightening device for urging the tray and the platform together. The platform is located beneath the ladder rung or a top shelf of a step ladder. The paint roller tray is located above either the rung or the top shelf. | 07-30-2015 |
Michael G. Beachy, Columbus, OH US
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20150232336 | METHOD FOR PRODUCING BN-BASED NANOPARTICLES AND PRODUCTS THEREFROM - A method of forming boron nitride nanoparticles. A plurality of precursor molecules comprising boron, nitrogen and hydrogen may be decomposed in a first heating zone to form a plurality of gaseous molecules that contain bonded boron and nitrogen, followed by heating to a second, higher temperature thereby causing the gaseous molecules to react and nucleate to form a plurality of boron nitride nanoparticles. Depending on processing temperatures, the boron nitride nanoparticles may include amorphous, crystalline, and spherical forms, or combinations thereof. Precursor molecules may include ammonia borane, borazine, cycloborazanes, polyaminoborane, polyiminoborane, and mixtures thereof. The boron nitride nanoparticles may be incorporated into a variety of dispersions, composites, and coatings; and in some embodiments, may be a component of a propellant. | 08-20-2015 |
Michael G. Beachy, Gahanna, OH US
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20130087071 | METHOD FOR PRODUCING BN-BASED NANOPARTICLES AND PRODUCTS THEREFROM - A method of forming boron nitride nanoparticles. A plurality of precursor molecules comprising boron, nitrogen and hydrogen may be decomposed in a first heating zone to form a plurality of gaseous molecules that contain bonded boron and nitrogen, followed by heating to a second, higher temperature thereby causing the gaseous molecules to react and nucleate to form a plurality of boron nitride nanoparticles. Depending on processing temperatures, the boron nitride nanoparticles may include amorphous forms, crystalline forms, or combinations thereof. Precursor molecules may include ammonia borane, borazine, cycloborazanes, polyaminoborane, polyiminoborane, and mixtures thereof. The boron nitride nanoparticles may be incorporated into a variety of dispersions, composites, and coatings; and in one embodiment, may be a component of a propellant, wherein the boron nitride nanoparticles may confer a range of advantages to gun barrels in which such propellants may be fired. | 04-11-2013 |
20140045081 | BIFUNCTIONAL ELECTRODE DESIGN AND METHOD OF FORMING SAME - A method for making a doped carbon bifunctional electrode capable of facilitating the oxygen reduction reaction and the oxygen evolution reaction that is not susceptible to performance degradation when operated bi-functionally for oxygen reduction and evolution. | 02-13-2014 |
Philip A. Beachy, Stanford, CA US
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20090203713 | Hedgehog pathway antagonists to treat disease - Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed. | 08-13-2009 |
20100080855 | HEDGEHOG SIGNALING AND CANCER STEM CELLS IN HEMATOPOIETIC CELL MALIGNANCIES - The present disclosure relates generally to methods of treating hematopoietic cell malignancy in a subject by administering to the subject a Hedgehog (Hh) pathway antagonist, such as a Smoothen (Smo) antagonist alone or in combination with an ABL-kinase antagonist. Specifically, the disclosure relates to a method of treating hematopoietic cell malignancy in a subject by administering the Hh pathway antagonist, such as the Smo antagonist cyclopamine, in combination with the ABL-kinase antagonist imatinib. | 04-01-2010 |
20110263519 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO - The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations. | 10-27-2011 |
20120171779 | ANTIBODIES THAT SPECIFICALLY BIND HEDGEHOG-DERIVED POLYPEPTIDES - The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′ CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. | 07-05-2012 |
20130109700 | Topical Itraconazole Formulations and Uses Thereof | 05-02-2013 |
20140135358 | Use of FK506 for the Treatment of Pulmonary Arterial Hypertension - A method of reducing pulmonary arterial hypertension in a mammal that employs FK506 is provided. In certain embodiments, the method comprises administering FK506 to a mammal having pulmonary arterial hypertension associated with defective MBPR2 signaling at a dosage sufficient to reduce blood pressure in the pulmonary artery of the mammal. | 05-15-2014 |
Philip A. Beachy, Baltimore, MD US
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20090186029 | Antibodies that specifically bind hedgehog-derived polypeptides - The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. | 07-23-2009 |
20110002941 | Antibodies that Specifically Bind Hedgehog-Derived Polypeptides - The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G′CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. | 01-06-2011 |
Philip A. Beachy, Towson, MD US
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20100069386 | Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto - The present invention makes available methods and reagents for inhibiting aberrant growth states resulting form hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. Such methods and reagents may also inhibit the hedgehog pathway in normal cells, e.g., where normal levels of hedgehog signalling are unwanted. | 03-18-2010 |
Philip A. Beachy, Philip Beachy, MD US
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20090088339 | IDENTIFICATION OF ACTIVATED RECEPTORS AND ION CHANNELS - The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels. | 04-02-2009 |
Philip A. Beachy, Ruxton, MD US
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20080255059 | Regulators of the hedgehog pathway, compositions and uses related thereto - The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations. | 10-16-2008 |
20100273818 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO - The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule. | 10-28-2010 |
20120135066 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO - The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations. | 05-31-2012 |
20120183603 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO - The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule. | 07-19-2012 |
Philip Arden Beachy, Stanford, CA US
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20090130091 | COMPOUNDS FOR HEDGEHOG PATHWAY BLOCKADE IN PROLIFERATIVE DISORDERS, INCLUDING HEMATOPOIETIC MALIGNANCIES - Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in hematopoietic malignancy cells, and determined to be associated with growth and proliferation of the malignancy cells. Accordingly, methods are provided for treating a hematopoietic cell malignancy associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a hematopoietic cell malignancy to treatment with an Hh pathway antagonist. | 05-21-2009 |
Robert Wisler Beachy, Crozet, VA US
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20140013558 | Tool system - One embodiment of the present invention is a drill motor assembly ( | 01-16-2014 |
Roger Beachy, St. Louis, MO US
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20140349852 | METABOLIC CONTROL OF SEED GERMINATION - This invention provides Methods of conveniently controlling seed germination in genetically modified plants by the administration of a chemical modulator. The plant comprises a hormone-regulating gene placed under the control of a gene switch. | 11-27-2014 |
Trent Beachy, Golden, CO US
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20140097607 | TEMPORARY TATTOO WITH RACE GUIDE ELEVATION MAP SYSTEM, AND METHOD OF NAVIGATING ELEVATION TERRAIN ON A RACECOURSE - There is disclosed a race guide elevation map system for navigating elevation terrain on a racecourse. In an embodiment, the system includes a temporary tattoo carrying an elevation map disposed thereon, the elevation map having distance demarcations in combination with elevation data. The system further includes a location input such as, for example, an elapsed-distance input, an elapsed-time input, or a coordinate input. The elevation map is configured to provide the athlete with the elevation terrain on the racecourse based on the location input. There is also disclosed a method of navigating elevation terrain on a racecourse. In an embodiment, the method includes affixing a temporary tattoo carrying an elevation map having distance demarcations in combination with elevation data. The method further includes receiving a location input to provide the athlete with the elevation terrain on the racecourse. | 04-10-2014 |
Wendell Beachy, Cincinnati, OH US
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20140299266 | METHODS AND SYSTEMS FOR MANUFACTURING ADVANCED COMPOSITE COMPONENTS - A fiber placement system for manufacturing composite components includes at least one material storage enclosure including a material spool assembly, a swiveling roller assembly, and a redirect roller assembly, for each tow to be produced per course, at least one material feeding/cutting station configured with a nip roller drive system, and a cutting mechanism, at least one material transfer station configured with an individual, moveable guide tray for each tow to be produced per course, the moveable guide trays respectively being configured with a vacuum system, and at least one layup station comprising a vacuum table/layup surface, and a pick-and-place device equipped with an end-effector. | 10-09-2014 |