Patent application number | Description | Published |
20090203144 | HIV-GAG CODON-OPTIMISED DNA VACCINES - The invention provides a nucleotide sequence that encodes an HIV- | 08-13-2009 |
20130302335 | LIGANDS THAT BIND TGF-BETA RECEPTOR II - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis. | 11-14-2013 |
20150361176 | LIGANDS THAT BIND TGF-BETA RECEPTOR II - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis. | 12-17-2015 |
Patent application number | Description | Published |
20110064819 | ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS - The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles using Hip agents. Also provided are compositions comprising particulate carriers obtainable by such methods and uses of such compositions in treatment. | 03-17-2011 |
20110256132 | MYOSTATIN BINDING PROTEINS - Description of antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. Furthermore, description of the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with anyone or a combination of decreased muscle mass, muscle strength and muscle function. | 10-20-2011 |
20120058116 | FGFR1C ANTIBODY COMBINATIONS - The invention relates to combinations of FGFR1c antagonists with agonist peptides and provide dual targeting proteins which bind to FEFR1c comprising an antigen binding protein which is capable of binding to FGFR1c and which is linked to one or more agonist peptides, methods of making such constructs and uses thereof, particularly in treating obesity. | 03-08-2012 |
Patent application number | Description | Published |
20100018710 | FRACTURING FLUID COMPOSITIONS, METHODS OF PREPARATION AND METHODS OF USE - The invention describes improved fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 01-28-2010 |
20100044048 | Non-toxic, green fracturing fluid compositions, methods of preparation and methods of use - The invention describes improved environmentally friendly, non-toxic, green fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of water-based mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 02-25-2010 |
20100044049 | GREEN COAL BED METHANE FRACTURING FLUID COMPOSITIONS, METHODS OF PREPARATION AND METHODS OF USE - The invention describes improved environmentally friendly, non-toxic, CBM friendly, green fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of water-based mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 02-25-2010 |
20100101796 | Hydrocarbon-based fracturing fluid compositions, methods of preparation and methods of use - The invention describes improved fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 04-29-2010 |
20120247776 | Hydrocarbon-Based Fracturing Fluid Compositions, Methods Of Preparation And Methods Of Use - The invention describes improved fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 10-04-2012 |
20130157904 | GREEN COAL BED METHANE FRACTURING FLUID COMPOSITIONS, METHODS OF PREPARATION AND METHODS OF USE - The invention describes improved environmentally friendly, non-toxic, CBM friendly, green fracturing compositions, methods of preparing fracturing compositions and methods of use. Importantly, the subject invention overcomes problems in the use of water-based mists as an effective fracturing composition particularly having regard to the ability of a mist to transport an effective volume of proppant into a formation. As a result, the subject technologies provide an effective economic solution to using high ratio gas fracturing compositions that can be produced in a continuous (i.e. non-batch) process without the attendant capital and operating costs of current pure gas fracturing equipment. | 06-20-2013 |
Patent application number | Description | Published |
20090200081 | SHEAR CUTTER DRILL BIT - A shear cutter drill bit for drilling a subterranean formation is provided having a bit body; a bit face on the bit body having at least a center zone, an efficiency zone, and an outer zone, the efficiency zone being located between the center zone and the outer zone; and a plurality of cutters having a backrake angle located on the bit face; wherein a majority of the cutters located in the efficiency zone of the bit face have a more aggressive backrake angle than a majority of the cutters located in the center zone of the bit face and a majority of the cutter located in the outer zone of the bit face. | 08-13-2009 |
20110067930 | ENHANCED SECONDARY SUBSTRATE FOR POLYCRYSTALLINE DIAMOND COMPACT CUTTING ELEMENTS - A cutting structure for a drill bit includes a diamond table affixed to one end of a first substrate. A second substrate is affixed to the other end of the first substrate. The second substrate is made from a different material than the first substrate. The first and second substrates are substantially coaxial. | 03-24-2011 |
20110127089 | ENHANCED CUTTER PROFILE FOR FIXED CUTTER DRILL BITS - In one aspect, a cutting structure for a drill bit includes cutters arranged to form a cutter profile. Substantially all of the cutters in a shoulder section of the cutter profile are positioned at a profile angle of at most 65°. In another aspect, substantially all of the shoulder cutters are arranged so that the longitudinal force exerted by each shoulder cutter onto an earthen formation is at least 25 percent of the normal force exerted by the shoulder cutter onto the earthen formation. | 06-02-2011 |
20150060149 | DRILL BIT HAVING SHEAR AND PICK-TYPE CUTTERS - A drill bit includes a bit body defining a plurality of blades extending from a selected distance from an axis of rotation of the bit body to a gage face. A plurality of only gouging cutters is mounted on the bit body. At least one of the plurality of blades has a blade top surface longitudinally behind the tips of the gouging cutters at a selected distance from the tips of the gouging cutters. | 03-05-2015 |