Patent application number | Description | Published |
20080206137 | 11C-Labeled Benzyl-Lactam Compounds and Their Use as Imaging Agents - The invention relates to “C-labeled compounds, their preparation, compositions comprising an effective amount of a “C-labeled compound, and the use of a “C-labeled compound as a radiopharmaceutical for positron emission tomography. | 08-28-2008 |
20080206147 | Method for the Use of [11C]Carbon Monoxide in Labeling Synthesis of 11C-Labelled Acids by Photo-Induced Free Radical Carbonylation Under Mild Conditions Using Sulfoxides - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with sulfoxides and triethylamine are provided. The resultant carbon-isotope labeled acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided. | 08-28-2008 |
20080226555 | Method for the Use of [11C] Carbon Monoxide in Labeling Synthesis of 11C-Labelled Esters and Acids by Sensitized Photo-Induced Free Radical - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols or water treated by photosensitizers are provided. The resultant carbon-isotope labeled esters and acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided. | 09-18-2008 |
20080279436 | Method and System of Multivariate Analysis on Volume-Wise Data of Reference Structure Normalized Images for Improved Quality in Positron Emission Tomography Studies - A method and system are provided to mask out the background in dynamic PET images, to perform pre-normalization on the masked dynamic PET images, and to apply multivariate image analysis (e.g., principal component analysis PCA) on the masked pre-normalized dynamic PET images in order to improve the quality of the dynamic PET images and the PET study. A masking operation applies PCA to untreated dynamic PEET images before any pre-normalization in order to mask out the background pixels. This masking operation uses the Otsu method. A first normalization method is background noise pre-normalization where pixel values are corrected for background noise. A second normalization method is kinetic pre-normalization where the contrast within an image is improved. Multivariate analysis such as PCA may be applied on the whole volume to find the largest variance in the structure. | 11-13-2008 |
20080293969 | 18F-Labeled Daa Analogues and Method of Labeling These Analogues as Positron Emission Tomography (Pet) Tracers For Imaging Peripheral Benzodiazepine Receptors - Methods for selecting novel DAA analogues for a peripheral type benzodiazepine receptor were labeled with | 11-27-2008 |
20080306313 | Non Thermal Plasma Method to Prepare [11C] Methyl Iodide From [11C] Methane and Iodine Methane and Iodine - A method and an apparatus for preparing [ | 12-11-2008 |
20080308735 | Diagnosis of Whiplash Associated Disorders (Wad) By Using Pet With D-[Methyl-11C]-Deprenyl (Dde) - Positron Emission Tomography (PET) tracers such as D-[methyl- | 12-18-2008 |
20080310697 | Method and System of Multivariate Analysis on Normalized Volume-Wise Data in the Sinogram Domain For Improved Quality in Positron Emission Tomography Studies - A method and system are provided for improving the quality in positron emission tomography (PET) images. PET input data is masked using raw dynamic PET data (sinograms) as input for primary component analysis (PCA) that generates primary components which in turn are used to create a mask. This mask can be used to allow object pixel data to be extracted from the sinograms into masked sinograms where background pixels outside the reference object are set to zero. A volume-wise approach to PCA uses masked sinograms as input data. Pixel-wise noise pre-normalization may then be performed generating pre-normalized sinograms from the masked PET input data. PCA is then performed on the pre-normalized sinograms resulting in PCA sinograms recreated into PCA-modified sinograms by adding background pixel values of zero. These PCA-modified sinograms may optionally be scaled and may then be reconstructed into dynamic PET images with improved image quality. | 12-18-2008 |
20090074279 | METHOD AND SYSTEM OF MULTIVARIATE ANALYSIS ON SLICE-WISE DATA OF REFERENCE STRUCTURE NORMALIZED IMAGES FOR IMPROVED QUALITY IN POSITRON EMISSION TOMOGRAPHY STUDIES - A method and system are provided for improving the quality in positron emission tomography (PET) images. Image quality may be improved by pre-normalizing dynamic PET images and then applying a multivariate analysis tool on the images to generate improved quality dynamic PET images. The dynamic PET images are the images reconstructed from the raw dynamic PET data in the image domain of the PET study. A first normalization method is a data treatment (also referred to as noise pre-normalization) for the negative values that may result from the image reconstruction and/or from random variations in detector readings. A second normalization method is background noise pre-normalization where background pixel values are masked. A third normalization method is kinetic pre-normalization where the contrast is improved to allow greater visualization of the activity in the image. Multivariate analysis such as PCA may then be applied to each slice of the dynamic PET images. | 03-19-2009 |
20090092549 | MINIATURIZED LIQUID SURFACE REACTIONS USING NANOMOLAR AMOUNTS OF CONCENTRATED [11C]CARBON DIOXIDE IN A STATIONARY GAS-PHASE - Methods and reagents for miniaturized carboxylation with carbon-isotope labeled carbon dioxide using Grignard reagents or other organometallic reagents in a closable reaction loop or reactor are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals or precursors for radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided. | 04-09-2009 |
20090104087 | PRODUCTION OF [18F]-F2 FROM [18F]-FLUORIDE USING A PLASMA INDUCED SCRAMBLING PROCEDURE - A method of producing [ | 04-23-2009 |
20090142264 | 18F-Labeled Phenoxyphenyl Nu-benzyl Alkanamid Derivatives for Positron Emission Tomography (PET) Imaging of Peripheral Benzodiazepine Receptor - The present invention provides novel | 06-04-2009 |
20090203909 | Method and apparatus for the use of [11C] Carbon Monoxide in Labeling Synthesis by Photo-Initiated Carbonylation - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided. | 08-13-2009 |
20090208414 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED KETONES BY PHOTO-INDUCED FREE RADICAL CARBONYLATION - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with carbanion precursors pretreated by a base are provided. The resultant carbon-isotope labeled ketones, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided. | 08-20-2009 |
20090220420 | TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR) - The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided. | 09-03-2009 |
20090285756 | 11C/18 F-LABELED INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 - The present invention relates to new | 11-19-2009 |
20090297445 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED AMIDES USING METAL AMIDES AND PHOT-INDUCED FREE RADICAL CARBONYLATION - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided. | 12-03-2009 |
20090297447 | SYNTHESIS AND EVALUATION OF 18F-LABELLED-ALKYL-1-[(1R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF BETA-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS - Radioactively labeled derivatives of (R)-3-(1-phenylethyl)-3H-imidazole-4-carboxylic acid esters and one-step methods for preparing these compounds are provided. The radioactively labelled compounds, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET) for the diagnosis of adrenal cortical masses such as incidentaloma, adenoma, primary and metastatic cortical carcinoma. Associated kits and method for PET studies are also provided. | 12-03-2009 |
20100061931 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED ESTERS BY PHOTO-INDUCED FREE RADICAL CARBONYLATION - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided. | 03-11-2010 |
20100063298 | 11C-LABELED BENZOPHENONE/BENZOXAZOLE ANALOGUES AS AN INFLAMMATION IMAGING AGENT - A method of preparing novel [ | 03-11-2010 |
20100150835 | Synthesis of [18F] Fluoromethyl Benzene Using Benzyl Pentafluorobenzenesulfonate - The present invention discloses the reactivity of ponytail (“PT”) sulfonates as leaving groups in nucleophilic fluorination reactions. The results showed that using a pentafluorobenzenesulfonate precursor is a suitable leaving group for n. c. a. nucleophilic | 06-17-2010 |
20100158804 | METHOD FOR THE USE OF [11C] CARBON MONOXIDE IN LABELING SYNTHESIS OF 11C-LABELLED ESTERS AND ACIDS BY SENSITIZED PHOTO-INDUCED FREE RADICAL CARBONYLATION - Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols or water treated by photosensitizers are provided. The resultant carbon-isotope labeled esters and acids, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits and method for PET studies are also provided. | 06-24-2010 |
20100228060 | PERFLUORO-ARYLIODONIUM SALTS IN NUCLEOPHILIC AROMATIC 18F-FLUORINATION - The present invention describes using fluorous chemistry in n.c.a. nucleophilic aromatic 18F-fluorination reactions by using perfluoro-aryliodonium salts as a precursor for aromatic nucleophilic substitution using a [18F] F-anion to displace a suitable leaving group from an electron deficient benzene ring. The results showed that using perfluoro-aryliodonium salts as a precursor is a suitable leaving group for n. c. a. nucleophilic aromatic 18F-fluorination in synthesis. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. Thus, it is possible to use this PT methodology to simplify and speed up purification methods. | 09-09-2010 |
20100233082 | 68GA-Labeled Peptide-Based Radiopharmaceuticals - The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. | 09-16-2010 |
20100234611 | Fluorination Process of Anilide Derivatives and Benzothiazole Fluorinate Derivatives as in VIVO Imaging Agents - The invention relates to a process for preparation of a compound of formula (I): R | 09-16-2010 |
20100258138 | RADIOLABELED 1-ACETATE PET IMAGING FOR RADIOTHERAPY IN HEAD AND NECK CANCER - The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Methods for in vivo imaging uses of the PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are also provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well. | 10-14-2010 |
20100275734 | PURIFICATION OF 68GE/68GA GENERATOR ELUATE FROM FE(III) INTENDED TO IMPROVE SPECIFIC RADIOACTIVITY OF 68GA-BASED RADIOPHARMACEUTICALS - The present invention provides a method of purifying | 11-04-2010 |
20110065914 | PERFLUORO MACROCYCLES IN 18F-LABELLING OF MACROMOLECULES - The invention relates to a synthetic strategy of using perfluoro crown ethers and other macrocycles to bind to [18F]-labelled fluorination reactions. The optional use of implementing perfluoro kryptofix 2.2.2 in this process is also disclosed. The present invention also claims perfluoro kryptofix structures that are suitable for use in 18F-labelling of fluorous based structures. | 03-17-2011 |
20110117012 | RADIOLABELED GALLIUM COMPLEXES, METHODS FOR SYNTHESIS AND USE FOR PET IMAGING OF EGFR EXPRESSION IN MALIGNANT TUMORS - The Invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. | 05-19-2011 |
20110251432 | SYNTHESIS OF [18F]-LABELLED ALKYL MESYLATES USING FLUOROUS SPE SEPARATION - The invention relates to new processes for preparation of | 10-13-2011 |
20110293518 | DIAGNOSIS OF WHIPLASH ASSOCIATED DISORDERS (WAD) BY USING PET WITH D-[METHYL-11C]-DEPRENYL (DDE) - Positron Emission Tomography (PET) tracers such as D-[methyl- | 12-01-2011 |
20120045106 | IMAGE ANALYIS METHOD AND SYSTEM - The invention relates to a system and method for enhancing image data obtained from a positron emission tomography (PET) scan. In various embodiments, the method comprises transforming an original image data set to provide a first modified image data set by performing a masked volume-wise principal component analysis (MVW-PCA) on the original image data set. The first modified image data set is then transformed to provide a second modified image data set by performing a masked volume-wise independent component analysis (MVW-ICA) on the first modified image data set, the second modified image data set thereby comprising enhanced image data. | 02-23-2012 |
20120177569 | LABELLED BIOTIN CONJUGATES - The present invention provides radioactive gallium complexes which comprise DOTA-biotin conjugates, incorporating a linker group. Also described are radiopharmaceutical compositions, and methods and uses of the complexes for in vivo imaging involving pre-targeting with avidin. | 07-12-2012 |
20120178902 | METHOD FOR OBTAINING 68GA - The present invention relates to a method of obtaining | 07-12-2012 |
20130005984 | 11C-LABELED BENZOPHENONE/BENZOXAZOLE ANALOGUES AS AN INFLAMMATION IMAGING AGENT - A method of preparing novel [ | 01-03-2013 |
20130225829 | FLUORINATION PROCESS - The invention relates to a process for preparation of a compound of formula (I): | 08-29-2013 |