Bonini
Emiliano Bonini, Novellara (re) IT
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20150151425 | EXTENSIBLE BAR HANDLE - An embodiment of the present invention relates to an extensible bar handle ( | 06-04-2015 |
Eric R. Bonini, Greer, SC US
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20100061862 | AIRFOIL SHAPE FOR A COMPRESSOR BLADE - An article of manufacture having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in TABLE A. X and Y are distances in inches which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z in inches. The profile sections at the Z distances can be joined smoothly with one another to form a complete airfoil shape. | 03-11-2010 |
20100092284 | AIRFOIL SHAPE FOR A COMPRESSOR - An article of manufacture having a nominal profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in TABLE 1. X and Y are distances in inches which, when connected by smooth continuing arcs, define airfoil profile sections at each distance Z in inches. The profile sections at the Z distances are joined smoothly with one another to form a complete airfoil shape. | 04-15-2010 |
Eric Richard Bonini, Greenville, SC US
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20140271109 | AXIAL COMPRESSOR AND METHOD FOR CONTROLLING STAGE-TO-STAGE LEAKAGE THEREIN - The present application and the resultant patent provide an axial compressor for a gas turbine engine. The compressor may include a rotor disk positioned along an axis of the compressor. The rotor disk may include a slot defined about a radially outer surface of the rotor disk, and the slot may include a slot planar surface facing away from the rotor disk. The compressor also may include a compressor blade coupled to the rotor disk via the slot. The compressor blade may include a platform positioned over the radially outer surface of the rotor disk, and the platform may include a platform sealing edge facing toward the rotor disk. The compressor further may include a gap defined between the platform sealing edge and the slot planar surface, wherein the gap is configured to control a flow of leakage air from a high-pressure side of the compressor blade to a low-pressure side of the compressor blade. The present application and the resultant patent further provide a related method of controlling stage-to-stage leakage in an axial compressor of a gas turbine engine. | 09-18-2014 |
Eric Richard Bonini, Greer, SC US
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20130043009 | COMPONENTS WITH COOLING CHANNELS AND METHODS OF MANUFACTURE - A component is provided and includes a substrate comprising an outer and an inner surface, where the inner surface defines at least one hollow, interior space. The component defines one or more grooves, where each groove extends at least partially along the outer surface of the substrate and has a base and a top. The base is wider than the top, such that each groove comprises a re-entrant shaped groove. One or more access holes are formed through the base of a respective groove, to connect the groove in fluid communication with the respective hollow interior space. Each access hole has an exit diameter D that exceeds the opening width d of the top of the respective groove. The diameter D is an effective diameter based on the area enclosed. The component further includes at least one coating disposed over at least a portion of the surface of the substrate, wherein the groove(s) and the coating together define one or more re-entrant shaped channels for cooling the component. A method for manufacturing the component is also provided. A method for manufacturing a component is also provided, where the groove and the access hole(s) are machined as a single continuous process, such that the groove and the access hole(s) form a continuous cooling passage. | 02-21-2013 |
20130336798 | AIRFOIL SHAPE FOR A COMPRESSOR - An article of manufacture having a nominal airfoil profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in a scalable table, the scalable table selected from the group of tables consisting of TABLES 1-11, wherein the Cartesian coordinate values of X, Y and Z are non-dimensional values convertible to dimensional distances by multiplying the Cartesian coordinate values of X, Y and Z by a number, and wherein X and Y are coordinates which, when connected by continuing arcs, define airfoil profile sections at each Z height, the airfoil profile sections at each Z height being joined with one another to form a complete airfoil shape. | 12-19-2013 |
20140030098 | ARTICLE OF MANUFACTURE - An article of manufacture has a first component configured for use with a turbomachine. The first component is configured for attachment to a second component, and reduces the possibility of attachment with an undesired third component by modification of a. characteristic of the first component. This modification is matched by a complementary characteristic of the second component. The first component has a nominal airfoil profile substantially in accordance with Cartesian coordinate values of X, Y and Z set forth in a scalable table selected from the group consisting of TABLES 1-11. Cartesian coordinate values of X, Y and Z are non-dimensional values convertible to dimensional distances by multiplying by a number. X and Y are coordinates which, when connected by continuing arcs, define airfoil profile sections at each Z height. The airfoil profile sections at each Z height being joined with one another to form a complete airfoil shape. | 01-30-2014 |
20140070457 | METHODS OF FORMING A CERAMIC COMPONENT AND A HIGH TEMPERATURE MOLD COMPONENT FOR USE THEREWITH - Methods of forming a ceramic component and a high temperature mold for use therewith are provided. The method includes providing a fixture having a receiving surface configured to receive an unfired ceramic component. The method includes applying a continuous high temperature membrane to a surface of the unfired ceramic component. The method includes covering the continuous high temperature membrane and unfired ceramic component with a high temperature loose media. The method includes heating the unfired ceramic component to a firing temperature. The high temperature mold includes the fixture and a support structure forming a compartment surrounding the fixture. The mold allows the high temperature loose media to be contained within the compartment and to cover the continuous high temperature membrane. The continuous high temperature membrane and high temperature loose media are evenly distributed over the uncured ceramic component and operable to provide constant pressure during processing using the mold. | 03-13-2014 |
20140083639 | BACKSTRIKE PROTECTION DURING MACHINING OF COOLING FEATURES - A method of machining a component is provided. The component includes a substrate having an outer surface and an inner surface, where the inner surface defines at least one interior space. A core is disposed within each interior space. The method includes forming at least one hole in the substrate while the core is disposed within the respective interior space. Each hole extends through the substrate to provide fluid communication with the respective interior space. The method further includes removing the core from the respective interior space. The core may be a casting core or a subsequently formed core. | 03-27-2014 |
20150367460 | METHODS OF FORMING COOLING CHANNELS USING BACKSTRIKE PROTECTION - A method of forming cooling channels in a component is provided. The component has a substrate having outer and inner surfaces. The inner surface defines at least one interior space, and a core is disposed within each interior space. The method includes forming at least one access hole in the substrate, while the core is disposed within the respective interior space, removing the core from the respective interior space, and forming at least one groove in the outer substrate surface (before or after the core is removed). Each access hole connects the groove in fluid communication with the respective interior space. The method further includes disposing a coating over at least a portion of the outer substrate surface, where the coating includes at least a structural coating that extends over the groove(s), such that the groove(s) and the structural coating together define one or more channels configured to convey a coolant from the respective interior space(s) for cooling the component. | 12-24-2015 |
Marcelo Bonini, Chicago, IL US
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20150376680 | PCL Compounds, Compositions, And Methods Of Use Thereof - Disclosed herein are compounds useful for detecting oxidants in a living cell, in a multicellular organism, or in a cell-free sample. In particular, disclosed herein are bioluminescent reporter compounds, and more particularly, fluorinated peroxy-caged-luciferin (PCL) compounds, compositions comprising such compounds, methods of using such compounds and compositions, and processes for preparing such compounds. Also disclosed herein are kits and methods for detecting and measuring peroxynitrite, and optionally, additional oxidants in a living cell, in a multicellular organism, or in a cell-free sample. | 12-31-2015 |
Marco Bonini, Florence IT
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20150078892 | ECCENTRIC COUPLING DEVICE AND METHOD FOR COUPLING MATING CASINGS IN A TURBOMACHINE - Turbomachines, coupling devices and methods for coupling a first casing and an second casing together are provided. The first casing and second casing include mating bore holes defined in mating flanges thereof, which may be misaligned. The coupling device may include a bushing insertable and positionable within one of the mating bore holes, and a pin insertable and positionable within the bushing and the other of the mating bore holes. The bushing and pin may each include eccentric features which may facilitate insertion into the mating bore holes when the bore holes are misaligned, thus coupling the first casing and second casing together. | 03-19-2015 |
Maria Chiara Bonini, Peschiera Borromeo (mi) IT
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20110158957 | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases - Disclosed herein are methods and compositions for inactivating TCR genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain in conditions able to preserve cell viability. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided. Disclosed herein are also methods and compositions for expressing a functional exogenous TCR in the absence of endogenous TCR expression in T lymphocytes, including lymphocytes with a central memory phenotype. Polynucleotides encoding exogenous TCR, vectors comprising polynucleotides encoding exogenous TCR and cells comprising polynucleotides encoding exogenous TCR and/or cells comprising exogenous TCR are also provided. | 06-30-2011 |
20120027802 | USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES - It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed. | 02-02-2012 |
20150306142 | USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES - It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed. | 10-29-2015 |
Maria Chiara Bonini, Milan IT
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20140301990 | TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES - Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes. | 10-09-2014 |
Maria Chiara Bonini, Milano IT
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20100035282 | USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES - It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed. | 02-11-2010 |
Nancy Bonini, Narberth, PA US
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20110142789 | Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis - Compositions and methods for diagnosis and treatment of ALS are provided. | 06-16-2011 |
Simone Bonini, Campagnola Emilia (re) IT
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20150151425 | EXTENSIBLE BAR HANDLE - An embodiment of the present invention relates to an extensible bar handle ( | 06-04-2015 |
Stefano Bonini, Brissago CH
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20150069023 | METHOD AND APPARATUS FOR SPARK-EROSION MACHINING OF A WORKPIECE - The invention relates to a method for electrical discharge machining of workpieces by electrical discharge pulses generated by a power module of an electrical discharge machine. The invention is characterized in that firstly the discharge voltage of a number N | 03-12-2015 |
Stefano Bonini, Rome IT
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20090118177 | USE OF NERVE GROWTH FACTOR IN EYE-DROPS FOR THERAPY OF PATHOLOGIES OF THE CENTRAL NERVOUS SYSTEM, SUCH AS ALZHEIMER'S AND PARKINSON'S DISEASE - Nerve growth factor (NGF), in the form of a preparation for administration on the ocular surface, is proposed for use in the therapy and/or prophylaxis of pathologies affecting brain tissues and encephalic structures, with particular reference to pathologies affecting the hippocampus, cerebral cortex, basal forebrain, medial septum, Broca's diagonal band, Meynert's basal nucleus, substantia nigra pars compacta, striatum and cerebellum. Applied in the form of an external ophthalmic preparation, for example, as eye-drops or ointment, the NGF is able to pass from the ocular surface to the brain tissues, and has been found to exert a therapeutic action on pathologies of the central nervous system, and particularly on Alzheimer's Disease and Parkinson's Disease. | 05-07-2009 |