Patent application number | Description | Published |
20090048436 | Methods of synthesizing chemically cleavable phosphoramidite linkers - The present invention provides a method of synthesizing phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linker has the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleaves to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleaves completely under conditions that are already used in cleavage/deprotection processes so it is fully compatible with conditions that are common in laboratories and does not require additives that necessitate further purification after cleavage, (iv) integrates easily onto commercially available synthesizers because it is compatible with standard coupling chemistry, and (v) is compatible with DNA, RNA, forward, reverse, and LNA, synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art. | 02-19-2009 |
20100285470 | MONOMETHINE DYES - Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment, the dye is useful in quantitative RT-PCR. | 11-11-2010 |
Patent application number | Description | Published |
20140258928 | SYSTEM AND METHOD FOR CONTROLLING FEATURES - A system, and related method and computer program product are disclosed. The system may comprise a lighting system including a plurality of light groups disposed on a Machine, each light group including one or more lights, a graphical user interface, and a controller. The controller may be configured to cause the graphical user interface to display a machine icon and a plurality of light icons. Each light icon may be in the shape of a light and corresponding to one of the light groups. Each light icon may be displayed proximal to the machine icon in a position generally indicative of a location on the Machine of the light group that corresponds to the light icon. In an embodiment, a light beam may be displayed generally adjacent to the first light icon to show a direction of light when the corresponding light group on the Machine is illuminated. | 09-11-2014 |
20140365031 | REMOTE OPERATOR STATION - A mounting structure for a remote operator station is provided. The mounting structure includes a frame having a first section, and a second section disposed adjacently in elevated relation with respect to the first section. The frame further includes a forward support member extending upward from an end of the first section and a rearward support member extending downward from an end of the second section. The structure further includes an upright support element removably coupled to the forward support member of the frame via a first coupling system. The structure further includes a laterally extending support element removably coupled to at least one of lateral sides of the second section of the frame via a second coupling system. | 12-11-2014 |
20150113464 | INDICATOR SYSTEM - An indicator system for displaying an operating parameter of a machine includes a display unit configured to provide a display within a defined screen space of the display unit. A monitoring module communicably coupled to the display unit configured for receiving a signal indicative of the operating parameter of the machine; comparing the operating parameter with a predetermined range; determining if at least one of the operating parameter and a rate of change of the operating parameter exceeds the pre-determined range; and illuminating a first icon on the primary display. The monitoring module is also configured for displaying the signal indicative of the operating parameter of the machine on the secondary display; and illuminating a second icon on the secondary display, based on the first icon on the primary display, the second icon being positioned adjacent to the dial. | 04-23-2015 |
Patent application number | Description | Published |
20080283513 | Heating Pad for Use with Animals - A heating pad for use with animals, or pet heating pad. The pet heating pad provides a pad with a cushioned exterior and a flexible but resilient interior that prevents overheating by maintaining or returning the pet heating pad to a flat profile. The pet heating pad heating system includes a heating element with temperature limitation controls for safe operation surrounded by layers of material selected for temperature control properties. The result is a pet heating pad that substantially reduces or eliminates the problems normally associated with heating pads such as hotspots, overheating, bunching, and folding while providing a pet with a physically and thermally comfortable surface upon which to rest. | 11-20-2008 |
20100050950 | Gravity-Induced Automatic Animal Watering/Feeding Device - Described is a gravity-induced automatic animal watering/feeding device that promotes increased sanitation and minimizes the amount of water/food spilled from the device in the event the device is overturned. More specifically, the animal watering/feeding device presents consumables, including water and animal food, to the animal using a receptacle that is removable from the remainder of the device. Because the receptacle is removable, it is easily replaced and/or removed for cleaning such that sanitation of the animal watering/feeding device is easily maintained. Additionally, selected components of the animal water/feeding device are releasably locked to one another such that the device minimizes the amount of water/food that is spilled from the device in the event it is overturned. | 03-04-2010 |
20120180730 | Universal Water Fountain System for Animals - A submersible, universal water fountain system for an animal watering vessel. The system includes a port for discharging water into the vessel, a housing which has an inlet through which water is drawn from the vessel, and a pump for drawing water through the inlet and forcing the water from the housing through the port back into the vessel. The port discharges water in a pattern to diminish overspray outside the vessel and create a stream-like flow path of water movement in the vessel to enhance the water drinking experience of an animal. | 07-19-2012 |
20120234247 | Energy Efficient Heated Pet Pad - A heated pet pad having a substantially oval shape and including a heating element to produce heat within the pet pad, a reflective layer mounted adjacent to the heating element to reflect heat toward the animal, and a support layer to contain the heating element and the reflective layer within the pet pad, the support layer including a plurality of support members extending from a first surface thereof to simulate a mattress spring, and a plurality of feet members extending from an opposite surface of the support layer to raise the pet pad off the external ground surface to inhibit heat loss. | 09-20-2012 |
20130305636 | Wall Entry Tunnel for a Pet Door - A wall entry tunnel for use with a pet door. The wall entry tunnel extends through a structural feature and forms an enclosed passageway connecting the interior and exterior frames of a pet door. The length of the wall entry tunnel adjusts to fit structural features of various thicknesses. The wall entry tunnel includes modular components that facilitate compact packaging and are readily assembled to construct the enclosed passageway with a perimeter sized to match the size of the pet door opening. | 11-21-2013 |
Patent application number | Description | Published |
20090203787 | VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS, METHODS OF PRODUCTION, AND USES - The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements and food products) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described herein (particularly C28-C38 PUFAs, also referred to herein as supraenes or supraenoics) by the expression, in a production host cell, of the full or partial sequence(s) of Elovl4 DNA/mRNA nucleic acids or ELOVL4 protein sequences encoded thereby, from any species (prokaryotic or eukaryotic) for use in the biosynthesis, production, purification and utilization of VLC-PUFAs in particular by the elongation of C18-C26 saturated fatty acids and PUFAs. The composition of the invention comprises, in various embodiments, a dietary supplement, a food product, a pharmaceutical formulation, a humanized animal milk, an infant formula, a cosmetic item and a biodiesel fuel for example. A pharmaceutical formulation can include, but is not limited to: a drug for treatment of neurodegenerative disease, a retinal disorder, age related maculopathy, a fertility disorder, particularly regarding sperm or testes, or a skin disorder. | 08-13-2009 |
20120071558 | COMPOSITIONS OF VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF USE - The present invention relates to processes for production of Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs). The present invention also relates to compositions (e.g., nutritional supplements, food products, and pharmaceutic compositions) containing such VLC-PUFAs. In one embodiment, the present invention is directed to methods for biosynthesis and production of the VLC-PUFAs described herein (particularly C28-C40 PUFAs, also referred to herein as supraenes or supraenoics) by the expression, in a production host cell, of the full or partial sequence(s) of Elovl4 DNA/mRNA nucleic acids or ELOVL4 protein sequences encoded thereby, from any species (prokaryotic or eukaryotic) for use in the biosynthesis, production, purification and utilization of VLC-PUFAs in particular by the elongation of C18-C26 saturated fatty acids and PUFAs. The composition of the invention comprises, in various embodiments, a dietary supplement, a food product, a nutritional formulation, a pharmaceutical formulation, a humanized animal milk, an infant formula, and a cosmetic item and for example. A pharmaceutical formulation can include, but is not limited to: a composition for enhancing neural development and function, a drug for treatment of neurodegenerative disease, an ocular disorder, a retinal disorder, age related maculopathy, a fertility disorder, particularly regarding sperm or testes, or a skin disorder. | 03-22-2012 |
20140100280 | TREATMENT METHODS USING VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS - Compositions that include Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are disclosed, along with methods of production and use thereof. | 04-10-2014 |
Patent application number | Description | Published |
20090092886 | COMPOSITE MULTILAYER SEAL FOR PEM FUEL CELL APPLICATIONS AND METHOD FOR CONSTRUCTING THE SAME - A composite seal having a multilayer elastomeric construction and method for constructing the same is provided. More specifically, the present invention provides a composite seal comprised of a low-durometer elastomer compliant layer coated with, or alternatively encapsulated by, a thin protective layer for securely sealing a bipolar plate and a membrane electrode assembly of a fuel cell. The elastomer compliant layer is preferably a silicone constituent and the thin coat protective layer is preferably a fluoroelastomer or fluoropolymer constituent suitable for bonding to the elastomer compliant layer. The foregoing layers constructing the composite seal are preferably deposited directly onto the aforementioned fuel cell components along a predetermined periphery. The resulting composite seal is thin in construction, resistive to undesired chemical and thermal reactions and provides the necessary compressive compliance without undue stress on the fuel cell assembly. | 04-09-2009 |
20100024968 | ADHESIVE INSTALLATION TOOL - A tool includes a body, a first cavity, a first porous top cover, and a first vacuum port. The first cavity is located on a first side of the body. The first porous top cover extends across the first cavity. A tool guide may attach to the body to align the tool with a component. | 02-04-2010 |
20100116297 | SYSTEM AND METHOD FOR COMPONENT RECOVERY - A component recovery system, configured to refurbish components, includes a fluid feed tank, a refurbishment compartment having a fluid delivery element, a waste tank, fluid lines connecting the fluid feed tank to the fluid delivery element and the refurbishment compartment to the waste tank, and pumps for delivering fluid through the fluid lines. The component recovery system removes field contaminants, coatings and bonding compounds from components. | 05-13-2010 |
20100236332 | FLUID PRESSURE OPERATED FIXTURE - A fixture includes a housing assembly defined along an axis. A pressure bar assembly is mounted to the housing assembly for movement relative the axis. A bladder assembly is mounted at least partially within the housing assembly such that pressurization of the bladder assembly is operable to exert a force on a workpiece along the axis with the pressure bar assembly. | 09-23-2010 |
20110061767 | COMPONENT REMOVAL TOOL AND METHOD - An apparatus includes a carriage, a first tooth, a second tooth, a feed block and a drive element. The first and second teeth are shaped for breaking bonds and attached to a first side of the carriage. The first and second teeth are spaced apart and generally parallel to each other. The drive element moves the carriage away from the feed block so that the first and second teeth break bonds when they encounter them. A method for removing a bonded component from a structure includes positioning a tool having first and second teeth between the component and the structure. The teeth are positioned between trailing edges of the component and the structure. The method includes driving the teeth from the trailing edges of the structure towards a leading edge of the structure to break bonds between the component and the structure so that the component can be removed. | 03-17-2011 |
20130067717 | METHOD OF INSTALLING A FLEXIBLE COMPONENT IN A U-SHAPED COMPONENT - An installation method makes use of a tool that includes a block and a plate. The block is configured to align the installation tool with a U-shaped component. The plate extends from the block and is configured to hold a flexible component, such that the flexible component is accurately located within the U-shaped component. | 03-21-2013 |
20130075011 | COMPOSITE MULTILAYER SEAL FOR PEM FUEL CELL APPLICATIONS AND METHOD FOR CONSTRUCTING THE SAME - A composite seal having a multilayer elastomeric construction and method for constructing the same is provided. More specifically, the present invention provides a composite seal comprised of a low-durometer elastomer compliant layer coated with, or alternatively encapsulated by, a thin protective layer for securely sealing a bipolar plate and a membrane electrode assembly of a fuel cell. The elastomer compliant layer is preferably a silicone constituent and the thin coat protective layer is preferably a fluoroelastomer or fluoropolymer constituent suitable for bonding to the elastomer compliant layer. The foregoing layers constructing the composite seal are preferably deposited directly onto the aforementioned fuel cell components along a predetermined periphery. The resulting composite seal is thin in construction, resistive to undesired chemical and thermal reactions and provides the necessary compressive compliance without undue stress on the fuel cell assembly. | 03-28-2013 |
Patent application number | Description | Published |
20120173264 | FACILITATING IDENTIFICATION OF POTENTIAL HEALTH COMPLICATIONS - Methods, computer storage media, systems and user interfaces for facilitating avoidance of potential health complications are provided. In one embodiment, the method includes identifying risk data that indicates a potential health risk to a patient. The risk data is used to determine a potential health complication that may arise in association with the patient. A plan of care is generated for the patient based on the potential health complication that may arise in association with the patient. Such a plan of care may include an action(s) to perform in association with the patient in an effort to avoid the potential health complication. | 07-05-2012 |
20120173265 | DEVELOPING AND MANAGING PERSONALIZED PLANS OF HEALTH - Methods, computer storage media, systems and user interfaces for facilitating development of personalized plans of health are provided. In one embodiment, the method includes referencing clinical data associated with a patient that was previously captured from a plurality of sources at corresponding clinical encounters. The clinical data can include static data that does not change over the lifetime of the patient and dynamic data that does change over the lifetime of the patient. The clinical data and evidence-based data are used to develop a personalized plan of health for the patient. Such a personalized plan of health provides a plan of health care for the patient in accordance with aggregate healthcare history of the patient. | 07-05-2012 |
20120173266 | REIMBURSING CARE PROVIDERS BASED ON PERFORMED ACTIONS - Methods, computer storage media, systems and user interfaces for reimbursing care providers using care tickets are provided. In embodiments, the method includes identifying a medically appropriate action(s) to perform during a clinical encounter for a patient that, if performed, results in a reimbursement to a care provider. The medically appropriate action(s) to perform during the clinical encounter for the patient is provided. An indication that the medically appropriate action(s) has been performed during the clinical encounter is received. Based on the performance of the medically appropriate action(s), reimbursement to the care provider is automatically initiated. | 07-05-2012 |
20120173286 | DEVELOPING AND MANAGING CARE TICKETS - Methods, computer storage media, systems and user interfaces for facilitating generation of care tickets are provided. In one embodiment, the method includes receiving context data associated with a clinical encounter at which a patient is seeking health care provided by a care provider. Clinical data associated with the patient is referenced. The clinical data includes historical health data for the patient. A care ticket is generated for the patient based on the context data and the clinical data. Such a care ticket including health information relevant to the clinical encounter at which the patient is seeking health care. | 07-05-2012 |
20130041687 | RECREATING THE STATE OF A CLINICAL SYSTEM - A method, system and medium are provided for enabling re-creation of a state of a computing system as it existed at a selected time. A plurality of data elements are tracked including functions and reference information employed in calculating one or more of the data elements. Versions of functions and reference information are also tracked. Thereby, a time at which to recreate the state of the system is selectable and the data elements that were available at or before the selected time are identifiable. And the versions of functions and reference information that were available at the selected time are identifiable. The state of the system at the selected time can thus be reviewed or analyzed as desired. | 02-14-2013 |
20130054262 | RECREATING A TIME-ORDERED SEQUENCE OF EVENTS - A method, system and medium are provided for enabling re-creation of a time-ordered sequence of clinical data. Sets of data elements for a patient are received in sequence from a clinical system, and for each data element a time stamp is attached. For any given set of data elements, a maximum time stamp is determined, implying that all events in a clinical system resulting in modifications to data elements contained in the set occurred on or before the maximum time stamp. A subsequent retrieval from a clinical system yields a set of data elements in which the time stamp for each data element occurs after the maximum time stamp from the previous set. | 02-28-2013 |
20130290020 | REAL-TIME AGGREGATION AND PROCESSING OF HEALTHCARE RECORDS - Methods, computer systems, and computer storage media are provided for utilizing clinical information in disparate formats or structures to generate multiple derived representations of the clinical information, each derived representation structured to meet a particular clinical need. Clinical information is aggregated from multiple, disparate data sources; the clinical information is in a first format. The information is restructured to generate a derived representation of the information; the derived representation is in a second format. The derived representation is communicated to a clinical application that meets the particular clinical need. | 10-31-2013 |
20140278481 | LARGE SCALE IDENTIFICATION AND ANALYSIS OF POPULATION HEALTH RISKS - Methods, systems, and computer-storage media are provided for facilitating the management of population health. A parallel processing architecture receives patient population health data from healthcare facilities along with one or more documents that are in human-readable form. From the human-readable document, computer-readable code is generated that includes high-level clinical logic is executed against the population health data to identify, among other things, patients in the population who qualify for health intervention programs. Using this information, healthcare facilities can implement management programs to help care for these patients. | 09-18-2014 |
20140278519 | Expression of Clinical Logic with Positive and Negative Explainability - Methods, systems, and computer-storage media are provided for providing explainability to an end-user on why a particular patient failed to qualify for a health-related measure. High-level clinical logic explainability rules are generated on top of high-level clinical logic used to identify members of a population who qualify and who do not qualify for the health-related measure. The explainability rules are designed to identify which components in the high-level clinical logic are not satisfied by the patient's health data, and, more specifically, which of the components' sub-criteria disqualified the patient from the health-related measure. The output of the explainability rules is structured into an easy-to-understand format that is presented on a user interface associated with an end-user such as a clinician. | 09-18-2014 |
20140278527 | LARGE SCALE IDENTIFICATION AND ANALYSIS OF POPULATION HEALTH RISKS - Methods, systems, and computer-storage media are provided for facilitating the management of population health. A parallel processing architecture receives patient population health data from healthcare facilities along with any updated data. A high-level clinical logic is executed against the data to identify, among other things, patients in the population who qualify for health intervention programs. Using this information, healthcare facilities can implement management programs to help care for these patients. | 09-18-2014 |