Bugge
Cliff Bugge, Portland, OR US
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20130186747 | Glancing Angle Mill - A method and system for forming a planar cross-section view for an electron microscope. The method comprises directing an ion beam from an ion source toward a first surface of a sample to mill at least a portion of the sample; milling the first surface, using the ion beam, to expose a second surface in which the end of the second surface distal to the ion source is milled to a greater depth relative to a reference depth than the end of the first surface proximal to the ion source; directing an electron beam from an electron source to the second surface; and forming an image of the second surface by detecting the interaction of the electron beam with the second surface. Embodiments also include planarzing the first surface of the sample prior to forming a cross-section. | 07-25-2013 |
20130307957 | Scanning Microscope Having an Adaptive Scan - A method of using a scanning microscope to rapidly form a digital image of an area. The method includes performing an initial set of scans to form a guide pixel set for the area and using the guide pixel set to identify regions representing structures of interest in the area. Then, performing additional scans of the regions representing structures of interest, to gather further data to further evaluate pixels in the regions, and not scanning elsewhere in the area. | 11-21-2013 |
20130344292 | Three Dimensional Fiducial - A method and system for forming and using a fiducial on a sample to locate an area of interest on the sample, the method comprising forming a fiducial by depositing a block of material on a sample proximal to an area of interest on the sample, the block of material extending from the surface of the sample to a detectable extent above the surface of the sample; and milling, using a charged particle beam, a predetermined pattern into at least two exposed faces of the block of material; subsequent to forming the fiducial, detecting the location of the area of interest by detecting the location of the fiducial; and subsequent to detecting the location of the area of interest, imaging or milling the area of interest with a charged particle beam. | 12-26-2013 |
20140217283 | TEM Sample Preparation - An improved method of preparing ultra-thin TEM samples that combines backside thinning with an additional cleaning step to remove surface defects on the FIB-facing substrate surface. This additional step results in the creation of a cleaned, uniform “hardmask” that controls the ultimate results of the sample thinning, and allows for reliable and robust preparation of samples having thicknesses down to the 10 nm range. | 08-07-2014 |
20150053548 | TEM SAMPLE PREPARATION - An improved method of preparing ultra-thin TEM samples that combines backside thinning with an additional cleaning step to remove surface defects on the FIB-facing substrate surface. This additional step results in the creation of a cleaned, uniform “hardmask” that controls the ultimate results of the sample thinning, and allows for reliable and robust preparation of samples having thicknesses down to the 10 nm range. | 02-26-2015 |
Diane Bugge, Rockaway, NJ US
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20080248089 | EDIBLE PRODUCTS FOR THE TREATMENT OF NASAL PASSAGES - The present invention relates to oral delivery systems, such as confectionery and chewing gum compositions, and methods for imparting the perception of nasal clearing to a user. In particular, the present invention includes confectionery and chewing gum compositions including a compound selected from 4-pentenyl isothiocyanate, 5-hexenyl isothiocyanate, 3-butenyl isothiocyanate, 3-methylthiopropyl isothiocyanate, and any combinations thereof and methods. The delivery systems promote the perception of nasal clearing in the user. | 10-09-2008 |
Frank Bugge, Berlin DE
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20130128911 | DIODE LASER AND METHOD FOR MANUFACTURING A HIGH-EFFICIENCY DIODE LASER - A diode laser having aluminum-containing layers and a Bragg grating for stabilizing the emission wavelength achieves an improved output/efficiency. The growth process is divided into two steps for introducing the Bragg grating, wherein a continuous aluminum-free layer and an aluminum-free mask layer are continuously deposited after the first growth process such that the aluminum-containing layer is completely covered by the continuous aluminum-free layer. Structuring is performed outside the reactor without unwanted oxidation of the aluminum-containing semiconductor layer. Subsequently, the pre-structured semiconductor surface is further etched inside the reactor and the structuring is impressed into the aluminum-containing layer. In this process, so little oxygen is inserted into the semiconductor crystal of the aluminum-containing layers in the environment of the grating that output and efficiency of a diode laser are not reduced as compared to a diode laser without grating layers that was produced in an epitaxy step. | 05-23-2013 |
John F. Bugge, Tucson, AZ US
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20140021289 | RESETTABLE MISSILE CONTROL FIN LOCK ASSEMBLY - A fin lock assembly | 01-23-2014 |
20150075357 | ACTUATION SYSTEM AND METHOD FOR MISSILE CONTAINER DOORS - A missile container sealing assembly includes an end cap capable of sealing an end of a container for a missile, and one or more linkage assemblies for controllably opening the end cap. The end cap has a frame portion that defines an opening for a missile and is mountable to the end of the missile container, and a door portion that includes one or more doors that close and seal the opening in the frame portion. Each linkage assembly is associated with a respective one of the one or more doors, for opening the doors relative to the frame portion. Moreover, each linkage assembly includes a link that transmits a force ahead of the leading end of the missile to open the doors and permit the missile's egress through the opening. | 03-19-2015 |
John Fawcett Roden Bugge, Tucson, AZ US
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20130032659 | RING GEAR CONTROL ACTUATION SYSTEM FOR AIR-BREATHING ROCKET MOTORS - A control actuation system for an air-breathing rocket motor propelled guided missile positions the drive motors and input gears in an inlet fairing extending aft of the air inlet towards the tail of the missile. The output gears are positioned coincident with and mechanically coupled to their respective tail fins spaced around the circumference of the missile. At least one of the tail fins is offset in a circumferential direction of the missile from its corresponding input gear and the inlet fairing. At least one ring gear is positioned around the exhaust tube to rotate in the circumferential direction of the missile. The ring gear comprises input and output teeth that engage the input and output gears, respectively, to actuate the tail fin. | 02-07-2013 |
Thomas Bugge, Bethesda, MD US
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20090142794 | Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors - The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. | 06-04-2009 |
20140378654 | MUTATED ANTHRAX TOXIN PROTECTIVE ANTIGEN PROTEINS THAT SPECIFICALLY TARGET CELLS CONTAINING HIGH AMOUNTS OF CELL-SURFACE METALLOPROTEINASES OR PLASMINOGEN ACTIVATOR RECEPTORS - The present invention provides methods of specifically targeting compounds to cells overexpressing matrix metalloproteinases, plasminogen activators, or plasminogen activator receptors, by administering a compound and a mutant protective antigen protein comprising a matrix metalloproteinase or a plasminogen activator-recognized cleavage site in place of the native protective antigen furin-recognized cleavage site, wherein the mutant protective antigen is cleaved by a matrix metalloproteinase or a plasminogen activator overexpressed by the cell, thereby translocating into the cell a compound comprising a lethal factor polypeptide comprising a protective antigen binding site. | 12-25-2014 |
Thomas H. Bugge, Bethesda, MD US
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20100168012 | HUMAN CANCER THERAPY USING ENGINEERED MATRIX METALLOPROTEINASE-ACTIVATED ANTHRAX LETHAL TOXIN THAT TARGETS TUMOR VASCULATUTURE - The present invention provides methods for inhibiting tumor associated angiogenesis by administering a mutant protective antigen protein comprising a matrix metalloproteinase-recognized cleavage site in place of the native protective antigen furin-recognized site in combination with a lethal factor polypeptide comprising a protective antigen binding site. Upon cleavage of the mutant protective antigen by a matrix metalloproteinase, the lethal factor polypeptide is translocated into cancer and endothelial cells and inhibits tumor associated angiogenesis. | 07-01-2010 |
20110280908 | MULTIMERIC PROTEIN TOXINS TO TARGET CELLS HAVING MULTIPLE IDENTIFYING CHARACTERISTICS - The present invention provides compositions comprising modified bacterial toxins and methods for using the modified bacterial toxins for targeting particular cell populations and for treating diseases. | 11-17-2011 |