Carney, TX
Darrell Carney, Dickinson, TX US
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20150359855 | METHODS OF USING THROMBIN DERIVATIVES TO TREAT MEDULLOBLASTOMA - Provided herein are methods for using a thrombin peptide derivative to treat a medulloblastoma. In one embodiment, the method includes administering to a subject having a medulloblastoma an effective amount of a thrombin peptide derivative, and exposing cells of the medulloblastoma of the subject to a cancer treatment after administering the thrombin peptide derivative to the subject. An example of a cancer treatment is radiation therapy. In one embodiment, viability of cells of the medulloblastoma is decreased compared to viability of cells of the medulloblastoma before the administering and the exposing. The cells of the medulloblastoma having decreased viability can be cancer stem cells. In one embodiment, shrinkage of the medulloblastoma in the subject is increased compared to shrinkage of the medulloblastoma before the administering and the exposing. | 12-17-2015 |
Darrell H. Carney, Galveston, TX US
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20080241149 | Antibodies to complementary peptides of thrombin or portions thereof - Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed. | 10-02-2008 |
Darrell H. Carney, Dickinson, TX US
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20090029923 | Use of thrombin-derived peptides for the therapy of chronic dermal ulcers - Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor. | 01-29-2009 |
20090054343 | Methods of therapy using pharmaceutical composition for thrombin peptide derivatives - Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above. | 02-26-2009 |
20090124550 | Thrombin peptide derivative dimers - Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above. | 05-14-2009 |
20090304671 | Method of treating endothelial dysfunction - Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders. | 12-10-2009 |
20100303793 | COMBINATION THERAPY FOR CARDIAC REVASCULARIZATION AND CARDIAC REPAIR - An agonist of the non-proteolytically activated thrombin receptor and an angiogenic growth factor can be used in combination in methods of therapy to stimulate cardiac revascularization, to stimulate vascular endothelial cell proliferation, to stimulate vascular endothelial cell migration and to promote repair of cardiac tissue. | 12-02-2010 |
20100330028 | COMBINATION THERAPY FOR CHRONIC DERMAL ULCERS - Disclosed is a method of promoting healing of a chronic dermal ulcer, such as a diabetic ulcer, in a subject. The method comprises administering to the subject a combination one or more agonists of the non-proteolytically activated thrombin receptor and one or more angiogenic growth factors. | 12-30-2010 |
20110110920 | METHOD OF TREATING PERIPHERAL ARTERIAL DISEASE - An agonist of a non-proteolytically activated thrombin receptor can be used in a method for treating peripheral arterial disease. The agonist can be a thrombin peptide derivative. In some embodiments, the peripheral arterial disease is characterized by intermittent claudication. The thrombin peptide derivatives to be used in the methods can have amino acid sequences similar to a region of thrombin. Usually, the thrombin peptide derivatives are 12-23 amino acid residues in length. In some cases, the thrombin peptide derivatives are dimers, and in particular, dimers that result from formation of a disulfide bond between two cysteine residues of peptide monomers. | 05-12-2011 |
20110117075 | THROMBIN DERIVED PEPTIDES FOR SMOOTH MUSCLE RELAXATION - Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures. | 05-19-2011 |
20110319340 | METHODS FOR TREATING CANCER - The present invention includes methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist. | 12-29-2011 |
20130101574 | METHODS OF USING THROMBIN PEPTIDE DERIVATIVES - The present invention provides methods of reducing mortality in a subject exposed to a lethal dose of radiation, methods of reducing the risk of developing bacterial, fungal or viral systemic infection in a subject who is exposed or not exposed to radiation, methods of prevention and treatment of oral complications, particularly oral complications as a result of treatment with chemotherapy or radiation therapy, methods of treating dermal ulcers, particularly diabetic dermal ulcers, pressure dermal ulcers, venous stasis ulcers, and arterial ulcers, methods of promoting bone growth, and methods of promoting cartilage growth and repair in a subject in need thereof, by administering a thrombin peptide derivative to a subject. The administration may be local or systemic. | 04-25-2013 |
20130130978 | METHOD OF TREATING ENDOTHELIAL DYSFUNCTION - Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders. | 05-23-2013 |
Darrell H. Carney, Dickson, TX US
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20110165142 | METHOD OF TREATING DEGENERATIVE DISEASES - Agonists of a non-proteolytically activated receptor can be used in methods for treating a disease or disorder in a subject. The methods comprise administering to the subject a therapeutically effective amount of an agonist, wherein the disease or disorder is scleroderma, macular degeneration, diabetic retinopathy, Huntington's disease, Parkinson's disease, closed head trauma, glaucoma, optic neuritis or allograft vasculopathy. | 07-07-2011 |
David B. Carney, College Station, TX US
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20130153395 | Devices and Methods for a Pyrolysis and Gasification System for Biomass Feedstock - A pyrolysis and gasification system produce a synthesis gas and bio-char from a biomass feedstock. The system includes a feed hopper that has a flow measurement device. The system also includes a reactor that is operable in a gasification mode or a pyrolysis mode. The reactor is configured to receive the biomass feedstock from the feed hopper. The reactor is operable to provide heat to the biomass feedstock from the feed hopper to produce the synthesis gas and bio-char. The system also includes a cyclone assembly. The produced synthesis gas including the bio-char is fed to the cyclone assembly. The cyclone assembly removes a portion of the bio-char from the synthesis gas. | 06-20-2013 |
20130205727 | Devices and Methods for a Pyrolysis and Gasification System for Biomass Feedstock - A pyrolysis and gasification system and method convert a biomass feed stock to bio-char and synthesis gas. In one embodiment, the pyrolysis and gasification system includes a reactor for producing a synthesis gas and bio-char from a biomass feedstock. The system includes a flow measurement device and an air distribution system, which provides a fluidized bed in the reactor. The system also includes a cyclone assembly. The cyclone assembly removes the bio-char from the synthesis gas. | 08-15-2013 |
Michael Carney, Houston, TX US
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20090300725 | ENABLING SYNCHRONOUS AND ASYNCHRONOUS COLLABORATION FOR SOFTWARE APPLICATIONS - A method for collaborating a first computer with a second computer. The method includes sending an invitation from the first computer to the second computer, and sending a list of permissions from the first computer to the second computer upon acceptance of the invitation. The list of permissions allows the second computer to access a limited portion of one or more data on the first computer. The method further includes performing an analysis on the limited portion of the data stored on the first computer by the second computer, and sending a notification from the second computer to the first computer, wherein the notification indicates that the analysis has been performed on the limited portion of the data. | 12-03-2009 |
20120046866 | OILFIELD APPLICATIONS FOR DISTRIBUTED VIBRATION SENSING TECHNOLOGY - Methods and apparatus for monitoring a hydrocarbon production system. A fiber optic sensor system is deployed into hydrocarbon production system, so as to extend to location of interest within the system, for instance, in conjunction with a downhole component or a surface component. The fiber optic system detects vibration present in the production system component, and provides a signal indicative of the vibration to a signal acquisition and analysis unit. The vibration of the production component is analyzed and a change in system flow condition/property or a change in production system component integrity is determined. | 02-23-2012 |
Stuart E. Carney, Austin, TX US
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20140207744 | MERGING COMPRESSED DATA ARRAYS - Compressed data sets can be merged without unraveling the compressed data sets. Concatenations of vectors of a first compressed data set that extend beyond a second compressed data set with no data vectors are represented in a third compressed data set. The no data vectors represent lack of data to be contributed from the second compressed data set. The third compressed data set represents a merger of the first and the second compressed data sets. Counterpart vectors of the first and second compressed data sets are determined using compression information for the vectors. Concatenations of the counterpart vectors are represented in the third compressed data set, as well as compression information that accounts for the determined counterpart vectors. | 07-24-2014 |
20140208053 | RE-ALIGNING A COMPRESSED DATA ARRAY - Two-dimensional compressed data sets can be re-aligned while preserving compression of the data. A set of one or more shifts and a corresponding set of one or more first dimension indices into a two-dimensional compressed data set for re-aligning the two-dimensional compressed data set are determined. Impact of re-aligning upon each vector in the second dimension of the two-dimensional compressed data set is determined while the two-dimensional compressed data set remains compressed. New compressed vectors are created in the second dimension resulting from re-aligning. Compression information is modified for each of the original vectors of the two-dimensional compressed data set that remain after re-aligning based, at least in part, on the new compressed vectors. A re-aligned version of the two-dimensional compressed data set is created with the new compressed vectors, and the remaining original vectors with their modified compression information. | 07-24-2014 |