Patent application number | Description | Published |
20080214867 | Continuous Crystallisation Process of Iodinated Phenyl Derivatives - The invention describes a process for the purification of iodinated aryl compounds where the purification is performed by continuous crystallisation of a crude product in a solvent with addition of anti-solvent. The continuous crystallisation process is performed in one or more crystallisers at a temperature up to the boiling point of the content of the crystalliser. | 09-04-2008 |
20090253935 | PREPARATION OF IODIXANOL - A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising 1-methoxy-2-propanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (“Compound A”). | 10-08-2009 |
20110021821 | CONTINUOUS ACETYLATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS - This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of acetylation of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”) followed by the removal of acetic anhydride. | 01-27-2011 |
20110021822 | CONTINUOUS DEACETYLATION AND PURIFICATION PROCESS IN SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS - This invention relates to an improved method for the synthesis of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, it relates to a continuous process of deacetylation of the acetylated hydroxyl group in 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide (“Compound B”) followed by crystallisations, filtration, and washing of Compound A. | 01-27-2011 |
20140322139 | STABILIZATION OF X-RAY DIAGNOSTIC COMPOSITION - The invention relates to a composition comprising a non-ionic X-ray contrast agent in a pharmaceutically acceptable carrier, and particularly to a supersaturated X-ray composition comprising X-ray contrast agents with a high dissolution temperature in water. Particularly, the invention provides such composition which is stable, and wherein crystallisation during storage is avoided. In a preferred aspect the X-ray contrast agent is Ioforminol and the composition includes a nucleation- and growth inhibitor. The invention further relates to a process for the preparation of such stable diagnostic X-ray composition. | 10-30-2014 |