Patent application number | Description | Published |
20080241186 | NUCLEIC ACID VACCINES FOR PREVENTION OF FLAVIVIRUS INFECTION - The invention encompasses nucleic acid molecules containing transcription units which encode the flavivirus M and E protein antigens. The flaviviruses include Japanese encephalitis virus, dengue, yellow fever virus and St. Louis encephalitis virus. The nucleic acids function to provide the M and E protein antigens when the nucleic acid resides in an appropriate host cell, especially when the host cell is the cell of a subject. The invention also encompasses a vaccine whose active agent is the nucleic acid. The invention further encompasses the cultured host cells when they contain within them nucleic acid molecules containing the transcription units. The invention in addition encompasses a method of immunizing a subject against flavivirus infection by administering to the subject an effective amount of a vaccine containing a nucleic acid molecule containing the transcription unit of the invention. | 10-02-2008 |
20080248064 | Localization and Characterization of Flavivirus Envelope Gylcoprotein Cross-Reactive Epitopes and Methods for their Use - Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glyco-protein cross-reactive epitopes and flavivirus E-glycoprotein crossreactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection. | 10-09-2008 |
20100003273 | NUCLEIC ACID VACCINES FOR PREVENTION OF FLAVIVIRUS INFECTION - The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection. | 01-07-2010 |
20100040643 | FLAVIVIRUS IMMUNOGENS AND METHODS OF USE - The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus or of a chimeric immunogenic flavivirus antigen comprising sequence from more than one flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection. The invention also provides antigens encoded by nucleic acids of the invention, antibodies elicited in response to the antigens and use of the antigens and/or antibodies in detecting flavivirus or diagnosing flavivirus infection. | 02-18-2010 |
20110059131 | LOCALIZATION AND CHARACTERIZATION OF FLAVIVIRUS ENVELOPE GLYCOPROTEIN CROSS-REACTIVE EPITOPES AND METHODS FOR THEIR USE - Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive epitopes having reduced or ablated cross-reactivity (and polypeptides comprising such epitopes), as well as methods of using these molecules to elicit an immune response against a flavivirus and to detect a flaviviral infection. | 03-10-2011 |
20120093862 | NUCLEIC ACID VACCINES FOR PREVENTION OF FLAVIVIRUS INFECTION - The invention encompasses nucleic acid molecules containing transcription units which encode the flavivirus M and E protein antigens. The flaviviruses include Japanese encephalitis virus, dengue, yellow fever virus and St. Louis encephalitis virus. The nucleic acids function to provide the M and E protein antigens when the nucleic acid resides in an appropriate host cell, especially when the host cell is the cell of a subject. The invention also encompasses a vaccine whose active agent is the nucleic acid. The invention further encompasses the cultured host cells when they contain within them nucleic acid molecules containing the transcription units. The invention in addition encompasses a method of immunizing a subject against flavivirus infection by administering to the subject an effective amount of a vaccine containing a nucleic acid molecule containing the transcription unit of the invention. | 04-19-2012 |
20140154283 | IDENTIFICATION OF A WEST NILE VIRUS CD4 T CELL EPITOPE AND USE THEREOF - Described herein is the identification and of a potent West Nile virus (WNV) CD4 positive T cell epitope and its use for increasing the immunogenicity of heterologous flavivirus vaccines, such as dengue virus type 2 (DENV-2) DNA and virus-like particle (VLP) vaccines. Also described are methods for the identification of potent T cell epitopes to enhance immunogenicity of multivalent vaccines. | 06-05-2014 |
20150246951 | LOCALIZATION AND CHARACTERIZATION OF FLAVIVIRUS ENVELOPE GLYCOPROTEIN CROSS-REACTIVE EPITOPES AND METHODS FOR THEIR USE - Disclosed herein is a method for identifying | 09-03-2015 |
Patent application number | Description | Published |
20090315007 | Impact load deflector sleeve and removable collar assembly for cable and post protection - A guard system for protecting cables or posts from damage by falling rocks and other dynamic forces is provided. The guard assembly comprises a first sleeve rotatably positionable about one of the cables or the posts and a second sleeve rotatably positionable about the cable or the post. A removable collar assembly is positioned between the first sleeve and the second sleeve for maintaining the spacing between the first sleeve and the second sleeve with the removable collar assembly comprising a first removable collar and a second removable collar. The first removable collar has a first slot for receiving the cable or post and the second removable collar has a second slot for receiving the cable or post with the first slot extending from a perimeter of the first removable collar to a point past a center point of the first removable collar and the second slot extending from a perimeter of the second removable collar to a point past a center point of the second removable collar. The first sleeve is free from any overlap and connection with the removable collar assembly and the second sleeve is free from any overlap and connection with the removable collar assembly. The first sleeve, the second sleeve, and the removable collar assembly are independently rotatable from each other. | 12-24-2009 |
20120319066 | IMPACT LOAD DEFLECTOR SLEEVE AND REMOVABLE COLLAR ASSEMBLY FOR CABLE AND POST PROTECTION - A method for protecting cables and posts from damage by providing at least one first sleeve cut to a desired length, positioning each first sleeve over the cable, inserting a screw through an aperture on a last first sleeve positioned on the cable until the screw contacts the cable, providing a second sleeve having an inside diameter greater than an outside diameter of the first sleeve, positioning the second sleeve over the first sleeves, tensioning the cable, securing an end of the cable, sliding the second sleeve over the end, positioning a removable collar assembly between the first and second sleeves, maintaining the first and second sleeves from overlapping the removable collar and each other, maintaining the first and second sleeves from connection with each other, removing the holding screws from the last first sleeve, and rotating the sleeves and the removable collar assembly independently from each other. | 12-20-2012 |