Chen, Palo Alto
Aiyou Chen, Palo Alto, CA US
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20150363502 | Optimizing personalized recommendations with longitudinal data and a future objective - Systems and techniques are provided for optimizing personalized recommendations with longitudinal data and a future objective. An identifier may be received for content items. A user content item history including a list identifying a previously acquired content item may be received. Content item metadata may be received including a correlation between the previously acquired content item and a content item for which an identifier was received, and a correlation between a content item for which an identifier was received and fulfillment of a future objective. A joint probability may be determined for each content item based on the user content item history and the content item metadata, including the probability that the content item will be acquired by the user after being recommended to the user and that a future objective will be fulfilled after the content item is acquired by the user. | 12-17-2015 |
Caifu Chen, Palo Alto, CA US
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20090087858 | Two-color Real-time/End-point Quantitation of MicroRNAs (miRNAs) - The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector probes, a single forward primer specific for the target polynucleotide, and a reverse primer can be employed in an amplification reaction to query the difference in expression level of the target polynucleotide between the two samples. In some embodiments a plurality of small miRNAs are queried with a plurality of linker probes. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 04-02-2009 |
20100015631 | CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME - The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures. | 01-21-2010 |
20100112573 | Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides - The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 05-06-2010 |
20100203545 | Two-color Real-time/End-point Quantitation of MicroRNAs (miRNAs) - The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector probes, a single forward primer specific for the target polynucleotide, and a reverse primer can be employed in an amplification reaction to query the difference in expression level of the target polynucleotide between the two samples. In some embodiments a plurality of small miRNAs are queried with a plurality of linker probes. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 08-12-2010 |
20100221717 | Methods, Compositions, and Kits for Detecting Allelic Variants - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 09-02-2010 |
20100285478 | Methods, Compositions, and Kits for Detecting Allelic Variants - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 11-11-2010 |
20110212494 | Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs - The present teachings provide methods, compositions, and kits for quantifying target, polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide. | 09-01-2011 |
20110257385 | METHODS FOR FLIP-STRAND IMMOBILIZING AND SEQUENCING NUCLEIC ACIDS - Provided herein are compositions, materials, methods and kits for immobilizing a template polynucleotide in a first orientation, and immobilizing a complementary sequence of the template polynucleotide in an orientation that is flipped compared to the orientation of the template polynucleotide. Provided herein are adaptive oligonucleotides that can be used in various nucleic acid manipulations to generate immobilized complement polynucleotides that are flipped in orientation compared to the orientation of the immobilized template polynucleotides. | 10-20-2011 |
20110281755 | Karyotyping Assay - This disclosure relates to methods and kits for karyotyping in which chromosomes are interrogated by amplifying loci that are not within copy number variable regions thereof. | 11-17-2011 |
20110287424 | METHYLATION-SPECIFIC COMPETITIVE ALLELE-SPECIFIC TAQMAN POLYMERASE CHAIN REACTION (CAST-PCR) - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating between different methylated and/or unmethylated nucleic acid loci. In certain embodiments, the inventions provides for detecting or quantitating undifferentiated embryonic stem cells in a population of differentiated cells. The invention is also useful for discriminating between fetal versus maternal cells, or healthy versus infected cells, or normal versus cancerous cells, or detecting reduction in viral load or measuring therapeutic efficiency in a patient, and more. | 11-24-2011 |
20120190019 | CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME - The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures. | 07-26-2012 |
20120214160 | Methods, compositions, and kits for detecting rare cells - Disclosed herein are methods for identifying rare cells containing particular markers and/or alleles from biological samples that have not been substantially pre-processed (e.g., unprocessed whole blood). The methods described herein provide a system for digital enrichment of target cells from a biological sample and detection of such target cells, thereby allowing accurate and efficient detection and/or enumeration of such cells in the sample. | 08-23-2012 |
20120301876 | METHOD TO QUANTIFY SIRNAS, MIRNAS AND POLYMORPHIC MIRNAS - The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleoitides that vary by as little as one nucleotide. | 11-29-2012 |
20130011840 | Methods, Compositions, and Kits Comprising Linker Probes for Quantifying Polynucleotides - The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer portion and the stem nucleotides. A detector probe, a specific forward primer, and a reverse primer can be employed in an amplification reaction wherein the detector probe can detect the amplified target polynucleotide based on the stem nucleotides introduced by the linker probe. In some embodiments a plurality of short miRNAs are queried with a plurality of linker probes, wherein the linker probes all comprise a universal reverse primer portion a different 3′ target specific portion and different stems. The plurality of queried miRNAs can then be decoded in a plurality of amplification reactions. | 01-10-2013 |
20140024543 | COMPOSITIONS FOR DETECTING FOODSTUFF SPOILAGE MICROORGANISMS - The invention provides nucleic acids, collections of nucleic acids, assay kits, and methods for the sensitive and specific detection of microorganisms in a foodstuff. The nucleic acid consists of a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-45. | 01-23-2014 |
20140147845 | CONCATAMERIC LIGATION PRODUCTS: COMPOSITIONS METHODS AND KITS FOR SAME - The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form a concatameric ligation product. In some embodiments of the present teachings, the concatameric ligation product can be amplified, and the identity and quantity of the target polynucleotides determined based on sequence introduced in the ligation reaction. Some embodiments of the present teachings provide methods for removing unligated probes from the reaction mixture. Some embodiments of the present teachings provide for highly multiplexed detection, identification, and quantification of a plurality of target polynucleotides using a variety of analytical procedures. | 05-29-2014 |
20140274774 | UNIVERSAL REPORTER-BASED GENOTYPING METHODS AND MATERIALS - The present disclosure is drawn to methods for detection, quantitation and analysis of nucleotides of interest, for example SNPs, in nucleic acid sequences of interest using universal FRET-based reporter primers. | 09-18-2014 |
20140377748 | Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs - The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA template, such as T4 DNA ligase. Following digestion to form an elongated target polynucleotide with a liberated end, a reverse transcription reaction can be performed, followed by a PCR. In some embodiments, the methods of the present teachings can discriminate between polymorphic polynucleotides that vary by as little as one nucleotide. | 12-25-2014 |
20150099644 | Method of Performing Digital PCR - A method of detection of a target nucleic acid is provided. The method includes fractionating a sample into a plurality of sample volumes wherein more than 50% of the fractions contain no more than 1 target nucleic acid molecule per sample volumes, and subjecting the plurality of sample volumes to conditions for amplification. The method further includes detecting a change in ion concentration in a sample volume wherein a target nucleic acid is present, counting the number of fractions with an amplified target nucleic acid, and determining the quantity of target nucleic acid in the sample. | 04-09-2015 |
20150105275 | Small RNA Capture, Detection and Quantification - Methods, compositions and kits for capturing, detecting and quantifying mature small RNAs are provided herein. Embodiments of the methods comprise ligating 5′ and 3′ ligation adaptors to the 5′ and 3′ ends of the mature small RNAs, respectively, in the presence of 5′ and 3′ semi-degenerate ligation splints to generate a ligation product. Other embodiments comprise reverse transcribing polyadenylated mature small RNA with a universal reverse transcription primer and ligating an adaptor to the 3′ end of the cDNA in the presence of a semi-degenerate ligation splint to generate a cDNA ligation product. | 04-16-2015 |
20150140557 | METHODS, COMPOSITIONS, AND KITS FOR DETECTING ALLELIC VARIANTS - In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions or deletions, in samples comprising abundant (e.g., wild type) allelic variants with high specificity and selectivity. In particular, in some embodiments, the invention relates to a highly selective method for mutation detection referred to as competitive allele-specific TaqMan PCR (“cast-PCR”). | 05-21-2015 |
Chang-Zheng Chen, Palo Alto, CA US
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20120196924 | METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs - The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. | 08-02-2012 |
20140187613 | METHODS AND PRODUCTS FOR EXPRESSION OF MICRO RNAs - The invention relates to microRNAs, methods of producing microRNAs and methods for using microRNAs. | 07-03-2014 |
Chi-Chung K. Chen, Palo Alto, CA US
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20090245246 | SYSTEMS AND METHODS FOR IMPROVING PACKET SCHEDULING ACCURACY - A packet scheduler is configured to perform quality of service (QoS) scheduling on a per-data unit basis. A downstream processing engine is operatively connected to the packet scheduler for receiving forwarded packets. A feedback path is operatively connected between the downstream processing engine and the packet scheduler for transmitting a net data unit change value reflecting a change in packet size between an output of the packet scheduler and an output of the downstream processing engine. | 10-01-2009 |
Chi-Chung Kenny Chen, Palo Alto, CA US
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20100158031 | METHODS AND APPARATUS FOR TRANSMISSION OF GROUPS OF CELLS VIA A SWITCH FABRIC - In one embodiment, a method can include receiving at an egress schedule module a request to schedule transmission of a group of cells from an ingress queue through a switch fabric of a multi-stage switch. The ingress queue can be associated with an ingress stage of the multi-stage switch. The egress schedule module can be associated with an egress stage of the multi-stage switch. The method can also include determining, in response to the request, that an egress port at the egress stage of the multi-stage switch is available to transmit the group of cells from the multi-stage switch. | 06-24-2010 |
20130121343 | METHODS AND APPARATUS FOR TRANSMISSION OF GROUPS OF CELLS VIA A SWITCH FABRIC - In one embodiment, a method can include receiving at an egress schedule module a request to schedule transmission of a group of cells from an ingress queue through a switch fabric of a multi-stage switch. The ingress queue can be associated with an ingress stage of the multi-stage switch. The egress schedule module can be associated with an egress stage of the multi-stage switch. The method can also include determining, in response to the request, that an egress port at the egress stage of the multi-stage switch is available to transmit the group of cells from the multi-stage switch. | 05-16-2013 |
Chieh Chen, Palo Alto, CA US
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20080213579 | Organic light emitting device having a protective barrier - In an organic light emitting device package including a plurality of layers of materials formed on a substrate the plurality of layers of materials including an organic light emitting layer a protective barrier for protecting the organic light emitting device from environmental degradation the protective barrier comprising a first semi-crystalline parylene-based layer an inorganic barrier layer and a second semi-crystalline parylene-based layer. | 09-04-2008 |
20100119839 | System and Method for Forming a Thin-Film Phosphor Layer for Phosphor-Converted Light Emitting Devices - A thin-film phosphor layer can be formed by an improved deposition method involving: (1) forming a phosphor powder layer that is substantially uniformly deposited on a substrate surface; and (2) forming a polymer binder layer to fill gaps among loosely packed phosphor particles, thereby forming a substantially continuous layer of thin film. | 05-13-2010 |
20100123386 | Phosphor-Coated Light Extraction Structures for Phosphor-Converted Light Emitting Devices - A conformal thin-film phosphor layer is disposed over a surface of a hemispherical lens, a Fresnel lens, or a microlens array, thereby forming a phosphor-coated light extraction structure. Also disclosed is a phosphor-converted photonic crystal light emitting device that incorporates a thin-film phosphor layer. A wafer-level packaging process incorporating a thin-film phosphor layer is also disclosed herein. | 05-20-2010 |
20130337719 | PHOSPHOR-COATED LIGHT EXTRACTION STRUCTURES FOR PHOSPHOR-CONVERTED LIGHT EMITTING DEVICES - A conformal thin-film phosphor layer is disposed over a surface of a hemispherical lens, a Fresnel lens, or a microlens array, thereby forming a phosphor-coated light extraction structure. Also disclosed is a phosphor-converted photonic crystal light emitting device that incorporates a thin-film phosphor layer. A wafer-level packaging process incorporating a thin-film phosphor layer is also disclosed herein. | 12-19-2013 |
20150275372 | SYSTEM AND METHOD FOR FORMING A THIN-FILM PHOSPHOR LAYER FOR PHOSPHOR-CONVERTED LIGHT EMITTING DEVICES - A thin-film phosphor layer can be formed by an improved deposition method involving: (1) forming a phosphor powder layer that is substantially uniformly-deposited on a substrate surface; and (2) forming a polymer binder layer to fill gaps among loosely packed phosphor particles, thereby forming a substantially continuous layer of thin film. | 10-01-2015 |
Chong Chen, Palo Alto, CA US
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20090080746 | System and method for automated magnetic resonance scan prescription for optic nerves - A method and system for automated magnetic resonance (MR) scan prescription is disclosed. A 3D MR scout image is obtained by an initial MR scan. The location of an optic nerve in the scout image is determined by registering a template image to the scout image using a hierarchical series of rigid registrations. The hierarchical series of rigid registrations utilizes a coarse to fine scheme to register regions in the template image to the scout image, starting with the whole template image and finishing with the optic nerve. A diagnostic MR scan is then aligned based on the location of the optic nerve in the scout image, and the diagnostic scan is performed resulting in a high quality diagnostic 3D MR image. | 03-26-2009 |
20090093706 | Automatic Alignment of Magnetic Resonance Imaging (MRI) Brain Scan By Anatomic Landmarks - A method to automatically align magnetic resonance (MR) brain scans for diagnostic scan planning, including: acquiring a three-dimensional (3D) localizer image of a patient; selecting a two-dimensional (2D) coronal view and a 2D transverse view from the localizer image; identifying a mid-sagittal plane (MSP) line in each of the coronal and transverse views and calculating a 3D MSP based on the MSP lines; reconstructing the localizer image based on an equation for the 3D MSP to obtain an image of the MSP of the patient's brain; identifying crista galli (CG) and tip of the occipital bone (TOB) in the image of the MSP of the patient's brain; calculating a transformation matrix based on the MSP, CG and TOB in the image and using the transformation matrix to obtain a scan plan for the patient; and outputting the scan plan for the patient. | 04-09-2009 |
Cuiping Chen, Palo Alto, CA US
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20120077878 | GASTRIC RETENTIVE DOSAGE FORMS FOR EXTENDED RELEASE OF ACAMPROSATE INTO THE UPPER GASTROINTESTINAL TRACT - Gastric retentive dosage forms for sustained release of acamprosate are described which may allow once- or twice-daily dosing for both acute and long-term treatment of a disorder including alcohol dependence, tinnitus, sleep apnea, Parkinson's disease, levodopa-induced dyskinesias in Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, Cortical spreading depression, migraine, schizophrenia, anxiety, tardive dyskinesia, spasticity, multiple sclerosis, various types pain, or binge eating. Methods of treatment using the dosage forms and methods of making the dosage forms are also described. | 03-29-2012 |
David H.c. Chen, Palo Alto, CA US
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20150205278 | SYSTEMS AND METHODS OF PROPERTY SECURITY - Systems and devices for and methods of energy management, property security and fire hazard prevention are provided. The systems, devices and methods are able to be centralized, computerized, and expandable. The devices and systems are capable of automatically reducing energy consumptions and minimizing losses of property caused by fire, theft, and vandalism using monitoring sensors (e.g., occupancy sensors) and computer software and equipments. | 07-23-2015 |
David H. C. Chen, Palo Alto, CA US
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20110238234 | SYSTEMS, DEVICES AND METHODS OF ENERGY MANAGEMENT, PROPERTY SECURITY AND FIRE HAZARD PREVENTION - Systems and devices for and methods of energy management, property security and fire hazard prevention are provided. The systems, devices and methods are able to be centralized, computerized, and expandable. The devices and systems are capable of automatically reducing energy consumptions and minimizing losses of property caused by fire, theft, and vandalism using monitoring sensors (e.g., occupancy sensors) and computer software and equipments. | 09-29-2011 |
Dongxue Chen, Palo Alto, CA US
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20130015350 | Electron-Beam Image ReconstructionAANM Chen; DongxueAACI Palo AltoAAST CAAACO USAAGP Chen; Dongxue Palo Alto CA USAANM Hu; ChangqingAACI SunnyvaleAAST CAAACO USAAGP Hu; Changqing Sunnyvale CA USAANM Pang; LinyongAACI Los GatosAAST CAAACO USAAGP Pang; Linyong Los Gatos CA US - A technique for reconstructing an electron-beam (EB) image, which can be a scanning-electron-microscope (SEM) image or an EB-inspection image, is described. This reconstruction technique may involve an inverse electro-optical calculation that corrects for the influence of an electro-optical transfer function associated with an EB system on the EB image. In particular, in the inverse calculation a multi-valued representation of an initial EB image is at an image plane in the model of the electro-optical transfer function and a resulting EB image is at an object plane in the model of the electro-optical transfer function. Furthermore, the model of the electro-optical transfer function may have an analytical derivative and/or may be represented by a closed-form expression. | 01-17-2013 |
Eugene I. Chen, Palo Alto, CA US
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20090309111 | SEMICONDUCTOR LIGHT EMITTING DEVICE INCLUDING GRADED REGION - One or more regions of graded composition are included in a III-P light emitting device, to reduce the V | 12-17-2009 |
Eunice Chen, Palo Alto, CA US
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20130034576 | NOVEL ADENOVIRUS ISOLATED FROM TITI MONKEYS - Provided is a Titi Monkey Adenovirus (TMAdV) that can infect both human and non-human primates. Further provided are nucleic acid sequences, proteins, expression vectors and host cells, anti-TMAdV antibodies, vaccines, compositions, methods of detecting TMAdV, methods for assaying for anti-TMAdV compounds, and methods for treating or preventing a TMAdV infection. | 02-07-2013 |
Francine Chen, Palo Alto, CA US
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20090306988 | SYSTEMS AND METHODS FOR REDUCING SPEECH INTELLIGIBILITY WHILE PRESERVING ENVIRONMENTAL SOUNDS - An audio privacy system reduces the intelligibility of speech in an audio signal while preserving prosodic information, such as pitch, relative energy and intonation so that a listener has the ability to recognize environmental sounds but not the speech itself. An audio signal is processed to separate non-vocalic information, such as pitch and relative energy of speech, from vocalic regions, after which syllables are identified within the vocalic regions. Representations of the vocalic regions are computed to produce a vocal tract transfer function and an excitation. The vocal tract transfer function for each syllable is then replaced with the vocal tract transfer function from another prerecorded vocalic sound. In one aspect, the identity of the replacement vocalic sound is independent of the identity of the syllable being replaced. A modified audio signal is then synthesized with the original prosodic information and the modified vocal tract transfer function to produce unintelligible speech that preserves the pitch and energy of the speech as well as environmental sounds. | 12-10-2009 |
Guoqing Chen, Palo Alto, CA US
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20110086834 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS - Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like. | 04-14-2011 |
20130273004 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 10-17-2013 |
20150231240 | ANTI-C16ORF54 ANTIBODIES AND METHODS OF USE THEREOF - The invention provides antibodies that bind C16orf54, including antibody-drug conjugates comprising the antibodies, and methods of use of the antibodies and the antibody-drug conjugates, including for the diagnosis and treatment of cancers. | 08-20-2015 |
James K. Chen, Palo Alto, CA US
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20100069386 | Modulators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto - The present invention makes available methods and reagents for inhibiting aberrant growth states resulting form hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. Such methods and reagents may also inhibit the hedgehog pathway in normal cells, e.g., where normal levels of hedgehog signalling are unwanted. | 03-18-2010 |
Jason Chen, Palo Alto, CA US
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20150339747 | Commercializing Manufacturer-Direct Products Under a Common Brand - An intermediary company markets products under its own brand name, but where the orders are between customers and the manufacturers, rather than with the intermediary company. In one implementation, the intermediary company operates primarily online. Its web site or other online presence is used to advertise the products and to take orders, and possibly also payment. The intermediary company authorizes third party operators to operate physical showrooms to display sample products. In return for their investment in the showrooms, the operators receive some commission on relevant sales. Since orders are primarily placed online, each operator's “territory” may include an online region. | 11-26-2015 |
Jer-Kang Chen, Palo Alto, CA US
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20080268440 | BIOMOLECULE IMMOBILIZATION ON SURFACE VIA HYDROPHOBIC INTERACTIONS - A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR. | 10-30-2008 |
20090142761 | METHODS AND KITS FOR METHYLATION DETECTION - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 06-04-2009 |
20090269759 | UNNATURAL POLYMERASE SUBSTRATES THAT CAN SUSTAIN ENZYMATIC SYNTHESIS OF DOUBLE STRANDED NUCLEIC ACIDS FROM A NUCLEIC ACID TEMPLATE AND METHODS OF USE - Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described. | 10-29-2009 |
20090308736 | APPARATUS AND METHOD FOR SPECIFIC RELEASE OF CAPTURED EXTENSION PRODUCTS - Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively released from a selected support by altering a physical property of that support. The released polynucleotides can be eluted from a common flow path and isolated. | 12-17-2009 |
20110143343 | Methods and Kits for Methylation Detection - Ligation-based methods and kits are disclosed for determining the degree of methylation of one or more target nucleotides. In certain embodiments, the methylation status of one or more target nucleotides is determined by generating misligation products. In certain embodiments, at least one target nucleotide is amplified prior to the ligation reaction. In certain embodiments, at least one ligation product, at least one ligation product surrogate, at least one misligation product, at least one misligation product surrogate, or combinations thereof are amplified. In certain embodiments, one or more ligation probes comprise at least one nucleotide analog, at least one Modification, at least one mismatched nucleotide, or combinations thereof. | 06-16-2011 |
20140187429 | Apparatus and Method for Specific Release of Captured Extension Products - Apparatus and methods for separating different polynucleotide populations in a mixture are provided, wherein different polynucleotides or polynucleotide populations are captured on different solid support. After hybridization, polynucleotides are selectively released from a selected support by altering a physical property of that support. The released polynucleotides can be eluted from a common flow path and isolated. | 07-03-2014 |
20150038368 | Biomolecule Immobilization On A Surface via Hydrophobic Interactions - A method, apparatus, or system for generating a pattern of polynucleotides on a substrate. The method includes providing a substrate having a hydrophobic surface. The method further includes conjugating a polystyrene moiety to a polynucleotide and applying a polystyrene-polynucleotide conjugate to create a plurality of reaction spots on the hydrophobic surface of the substrate. An apparatus includes a substrate with at least one polystyrene-polynucleotide conjugate on a surface of the substrate. A system can analyze a polystyrene-polynucleotide conjugate and the system may perform PCR. | 02-05-2015 |
Jiavu Chen, Palo Alto, CA US
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20120130241 | HANDHELD VOLUMETRIC ULTRASOUND SCANNING DEVICE - An apparatus and related methods for ultrasonically scanning a tissue volume are described, the apparatus being particularly advantageous in the context of freehand ultrasound assisted biopsy of the breast although readily applied to non-biopsy contexts and other body parts. The apparatus comprises a casing configured and dimensioned for single-handed manipulation relative to a surface of the tissue, and a texturably couplant-porous material sheet extending across an opening of the casing. The texturably couplant-porous material sheet has an outer side and an inner side relative to the casing, the outer side for compressively contacting the tissue surface. The apparatus further comprises an ultrasound transducer positioned against the inner side of the texturably couplant-porous material sheet and being mechanically translatable thereacross for volumetrically scanning the tissue volume therethrough. | 05-24-2012 |
Kay-Yut Chen, Palo Alto, CA US
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20100106600 | Publication Planning Based On Estimated Content Usage Parameters - Planning a publication includes receiving information about an event, accessing a database of profiles that relate in general to content usage, and using a search engine to match the profiles with the event information to estimate parameters for using content for the event. The publication is planned according to the estimated usage parameters. | 04-29-2010 |
Ke Chen, Palo Alto, CA US
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20150378913 | CACHING DATA IN A MEMORY SYSTEM HAVING MEMORY NODES AT DIFFERENT HIERARCHICAL LEVELS - A memory system includes a plurality of memory nodes provided at different hierarchical levels of the memory system, each of the memory nodes including a corresponding memory storage and a cache. A memory node at a first of the different hierarchical levels is coupled to a processor with lower communication latency than a memory node at a second of the different hierarchical levels. The memory nodes are to cooperate to decide which of the memory nodes is to cache data of a given one of the memory nodes. | 12-31-2015 |
Marilyn Chen, Palo Alto, CA US
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20110296468 | AUGMENTING TELEVISION MEDIA - This document describes techniques for, and apparatuses capable of, augmenting television media through a mobile computing device and/or a television-capable computing device. In one embodiment, a user's mobile computing device receives an event associated with a particular program of television media from the television-capable computing device, and, using this event, augments that television media through the mobile computing device with information associated with this event. | 12-01-2011 |
Mark H. Chen, Palo Alto, CA US
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20090086456 | TOOL-LESS BLADE EJECTOR LATCH WITH INTEGRATED SPRING - An ejector latch for removing a blade module from a server chassis includes a latch lever, an ejector catch, and an ejector pull part. The latch lever includes a pivot hole near a first end thereof operable to be coupled to the blade module and a bend near a second end thereof. The ejector catch includes a through-hole passing therethrough and a hook operable to hook onto the server chassis. The ejector pull part includes an integrated spring operable to return the ejector pull part to an original position after being pulled. The second end of the latch lever passes through the through-hole of the ejector catch. The ejector pull part is disposed on the bend near the second end of the latch lever and inside the through-hole of the ejector catch such that, when the ejector pull part is pulled, the ejector pull part slides along the bend near the second end of the latch lever and pushes on a wall of the through-hole to disengage the hook of the ejector catch from the server chassis. | 04-02-2009 |
20090320267 | EXPANSION CARD CARRIER AND METHOD FOR ASSEMBLING THE SAME - An expansion card carrier is disclosed, the expansion card carrier including a top portion for covering an expansion card, at least one side portion for supporting the top portion, and at least one pair of card guides for allowing an expansion card to slide along into the expansion card carrier. A method for assembling an expansion card carrier is also disclosed, the method including casting a panel including a top portion for covering an expansion card and at least one side portion for supporting the top portion, forming at least one side portion by deforming the panel, and attaching at least one pair of card guides inside the expansion card carrier for allowing an expansion card to slide along into the expansion card carrier. | 12-31-2009 |
Mingdeng Chen, Palo Alto, CA US
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20110037506 | DC OFFSET CALIBRATION FOR COMPLEX FILTERS - Exemplary techniques for DC offset calibration for complex filters are disclosed. A complex filter is provided having a first calibration path circuit and a second calibration path circuit, each including a first and a second set of switches, respectively. The first set of switches is enabled during calibration mode and the second set of switches is enabled during normal operation mode such that the network characteristics of each calibration path circuit are substantially the same during both modes of operation. In one embodiment, the complex filter is a low pass filter. | 02-17-2011 |
20120242378 | FREQUENCY DIVIDER CIRCUIT - A frequency divider circuit is described. The frequency divider circuit includes a first cross-coupling. The first cross-coupling includes a first cross-coupled transistor with a first gate. The first gate is separately biased. The first cross-coupling also includes a second cross-coupled transistor with a second gate. The second gate is separately biased. The first gate is coupled to the second cross-coupled transistor and the second gate is coupled to the first cross-coupled transistor. | 09-27-2012 |
Oswald Chen, Palo Alto, CA US
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20140366018 | METHOD AND SYSTEM FOR AUTOMATIC ASSIGNMENT AND PRESERVATION OF NETWORK CONFIGURATION FOR A VIRTUAL MACHINE - The disclosure herein describes a system, which provides network configuration to a respective network adapter of a large number of cloned virtual machines. During operation, the system stores one or more network identifiers assignable to a network adapter of a cloned virtual machine in a pool of virtual machines cloned from a parent virtual machine. A respective network identifier corresponds to a respective network configuration. The system then determines whether a network identifier for a network adapter of a cloned virtual machine is available. If so, the system assigns the network identifier to the network adapter in response to the network identifier being available, thereby associating the network adapter with the corresponding network configuration. | 12-11-2014 |
Pang-Chieh Chen, Palo Alto, CA US
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20100162039 | High Availability and Disaster Recovery Using Virtualization - There is disclosed apparatus and processes which address problems in the area of providing high availability and disaster recovery for computing systems and the data in them. These apparatus and processes can be used to provide high availability and disaster recovery for a computing system to be protected. The protected computing systems may be virtual computing systems. | 06-24-2010 |
Qiming Chen, Palo Alto, CA US
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20150205601 | Processing Streaming Data With Open Executors - Processing streaming data with open executors includes receiving input data at a computation dataflow station where the computation dataflow station contains a computation file and an open executor that accepts code plug-ins, converting contents of the computation file into a program string with the code plug-ins from a system library, and launching the program string together with the input data to calculate an output with a graphics processing unit. | 07-23-2015 |
20150269234 | User Defined Functions Including Requests for Analytics by External Analytic Engines - Described herein are techniques enabling a query engine to process a query comprising a user defined function. The user defined function can include a request for analytics to be performed by an external analytic engine. The query engine can retrieve data from a database in accordance with the query and send the data and instructions to perform the analytics to the external analytic engine. The query engine can then receive analytic results from the external analytic engine. | 09-24-2015 |
20150271236 | COMMUNICATING TUPLES IN A MESSAGE - Multiple tuples are combined ( | 09-24-2015 |
Shiah-Yun Chen, Palo Alto, CA US
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20090239896 | AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. The compounds include azaindoles of the formula below [insert FIG. | 09-24-2009 |
20090306171 | INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds according to the formula (I) or (II) optionally having additional heteroatoms, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. Formula (I), formula (II). R | 12-10-2009 |
20090318492 | INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS - Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject. | 12-24-2009 |
Shiao-Hua Chen, Palo Alto, CA US
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20110211280 | METHOD AND APPARATUS FOR AT LEAST ONE ACTUATOR ARM DAMPER COVERING AT LEAST ONE LIGHTENING HOLE IN A HARD DISK DRIVE TO REDUCE TRACK MIS-REGISTRATION (TMR) - This application discloses a hard disk drive, a head stack assembly, an actuator arm, and an arm damper configured for coupling to an actuator arm to create the head stack assembly used in the hard disk drive. The actuator arm has two arm dampers covering a lightening hole on either side of the actuator arm and configured to reduce the effects of airflow turbulence and mechanical vibration in the hard disk drive. Also disclosed, methods of operating the hard disk drive and of manufacturing for the head stack assembly and the hard disk drive. | 09-01-2011 |
20120287533 | DISK DRIVE SYSTEM WITH AIR DAMPER AND METHOD OF MANUFACTURE THEREOF - A method comprising: providing an arm actuation comprises a lightning hole; and attaching an air damper having a channel on the actuator arm and over the lightning hole, the air damper has the channel from a perimeter of the air damper. | 11-15-2012 |
Shu-Lu Chen, Palo Alto, CA US
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20090294869 | Negative Differential Resistance Device and Memory Using the Same - A negative differential resistance (NDR) device is designed and a possible compact device implementation is presented. The NDR device includes a voltage blocker and a current blocker and exhibits high peak-to-valley current ratio (PVCR) as well as high switching speed. The corresponding process and design are completely compatible with contemporary Si CMOS technology and area efficient. A single-NDR element SRAM cell prototype with a compact size and high speed is also proposed as its application suitable for embedded memory. | 12-03-2009 |
Shuyuan Chen, Palo Alto, CA US
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20080263086 | Systems and methods for information exchange using object warehousing - Embodiments of the present invention improve information exchange, and in particular, the exchange of data objects between different software systems. In one embodiment, the present invention includes a method of exchanging information comprising analyzing the attributes of the objects. Objects may be stored in a repository and retrieved using attributes. In some applications, objects are received and sent to participants without accessing any information in the objects themselves. Different applications include object warehousing operable across different communication mediums that support different names or name spaces, classes, aliases, groups, geospatial information, or tokens, or combinations thereof. | 10-23-2008 |
Tong Chen, Palo Alto, CA US
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20110285984 | Velocity measuring system - A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. | 11-24-2011 |
20130215410 | Velocity Measuring System - A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum. | 08-22-2013 |
20130215411 | Velocity Measuring System - A laser Doppler velocimeter uses self-mixing amplification of backreflections from scatterers below the surface of a flow. A time domain signal is divided into segments that are roughly equal to a transit time of particles through a focus of a laser beam. The segments are connected to a frequency domain through the use of an FFT algorithm to produce frequency domain data segments. Signal-to-noise ratio is enhanced through signal processing techniques using the segments to produce a final enhanced signal spectrum. | 08-22-2013 |
20140265826 | Asymmetrical Slow Wave Structures to Eliminate Backward Wave Oscillations in Wideband Traveling Wave Tubes - In various embodiments, a traveling wave amplifier circuit is disclosed. The traveling wave amplifier circuit is configured to receive an RF wave and an electron beam. The traveling wave amplifier effects synchronized interaction between the RF wave and the electron beam. The traveling wave amplifier circuit comprises a waveguide. The waveguide comprises a plurality of asymmetric cells arranged periodically. The waveguide is configured to receive an electron beam. Each of the asymmetric cells comprises at least one asymmetrical structure within the asymmetric cell to modify the dispersion relation of the waveguide. | 09-18-2014 |
20150082915 | CORIOLIS FLOW SENSOR FABRICATED WITH LAMINATED FILMS PROCESSES - A coriolis flow sensor is disclosed. The coriolis flow sensors comprises a first substrate layer, a second substrate layer, and a third substrate layer. The first substrate layer comprises a first wall. The second substrate layer comprises a second wall. The third substrate layer is disposed between the first and second substrate layers in a stacked configuration. The third substrate layer defines a flow path. The first and second walls of the respective first and second substrates and the flow path defined by the third substrate layer define a first flow channel configured to receive a fluid therethrough. A first actuator is configured to generate vibrations in the first flow channel. The first flow channel is mechanically moveable. | 03-26-2015 |
Tsungyen Chen, Palo Alto, CA US
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20140053246 | SELF-CONFIGURING WIRELESS NETWORK - Methods, systems, and apparatus, are provided for wireless networking In some implementations, a self-configuring wireless system includes at least one wireless network device; and an access point device; wherein the access point device and the at least one wireless network device are preconfigured with a common key so as to enable the access point device to establish a secure wireless network with the at least one network device using the common key upon powering up the access point device and the at least one wireless network device at a user site. | 02-20-2014 |
20140247941 | SELF-CONFIGURING WIRELESS NETWORK - Methods, systems, and apparatus, are provided for wireless networking. In some implementations, a self-configuring wireless system includes one or more wireless network devices; and an access point device, wherein the one or more wireless network devices are each preconfigured with a respective key, and wherein the access point device is configured to obtain the respective keys so as to enable the access point device to establish a secure wireless network with the one or more network devices using the respective keys upon powering up the access point device and the one or more wireless network devices at a user location. | 09-04-2014 |
20140281478 | CONFIGURING SECURE WIRELESS NETWORKS - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for configuring secure wireless networks. One of the methods includes receiving, at a security system management device, protocol and key information for establishing a connection as a client device to the wireless IP device, wherein the protocol and key information is received in response to a user transmitting an identifier for the IP device to a service provider system; establishing communication with the wireless IP device, wherein the wireless IP device is acting as an access point device; exchanging keys with the wireless IP device; rebooting the security system management device to become an access point for the secure wireless network; and establishing communication with the wireless IP device, wherein the wireless IP device has become a wireless client. | 09-18-2014 |
20140281990 | INTERFACES FOR SECURITY SYSTEM CONTROL - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for controlling security systems. One of the methods includes receiving, at a mobile device, an input to present camera video content; presenting, in a user interface, a first array of video content, wherein the respective video content is associated with a first security system location; receiving a user input to present a second array of video content, wherein the respective video content is associated with a second security system location, and wherein the user input comprises a touch input; and presenting, in the user interface, the second array of video content. | 09-18-2014 |
20150373538 | Configuring Secure Wireless Networks - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for configuring secure wireless networks. One of the methods includes receiving, at a security system management device, protocol and key information for establishing a connection as a client device to the wireless IP device, wherein the protocol and key information is received in response to a user transmitting an identifier for the IP device to a service provider system; establishing communication with the wireless IP device, wherein the wireless IP device is acting as an access point device; exchanging keys with the wireless IP device; rebooting the security system management device to become an access point for the secure wireless network; and establishing communication with the wireless IP device, wherein the wireless IP device has become a wireless client. | 12-24-2015 |
Weidong Chen, Palo Alto, CA US
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20110314105 | SYSTEM AND METHOD FOR ATTRIBUTE DETECTION IN USER PROFILE CREATION AND UPDATE - In one embodiment, a scheduled collaboration session in a social network is detected, the scheduled collaboration session to occur at a time in the future and at that time provide real-time communication among participants. A plurality of participants expected to attend the scheduled collaboration session are detected. A subject matter of the scheduled collaboration session is detected. One or more key words are derived from the detected subject matter of the scheduled collaboration session. Profiles maintained in the social network for the plurality of participants expected to attend the scheduled collaboration session are updated based on the one or more key words, the updating to include refining an area of expertise indicated in the profiles. | 12-22-2011 |
20140118472 | Active Speaker Indicator for Conference Participants - In one embodiment, a method includes receiving requests to join a conference from a plurality of user devices proximate a first endpoint. The requests include a username. The method also includes receiving an audio signal for the conference from the first endpoint. The first endpoint is operable to capture audio proximate the first endpoint. The method also includes transmitting the audio signal to a second endpoint, remote from the first endpoint. The method also includes identifying, by a processor, an active speaker proximate the first endpoint based on information received from the plurality of user devices. | 05-01-2014 |
Weitian Chen, Palo Alto, CA US
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20120262167 | ACCELERATED MULTISPECTRAL DATA MAGNETIC RESONANCE IMAGING SYSTEM AND METHOD - A method for processing magnetic resonance imaging data includes accessing the magnetic resonance imaging data, the data including a plurality of magnetic resonance data sets each collected at different excitation frequencies and defining reconstructable images representative of sections of a single image of a subject. Each magnetic resonance data set includes sampled data for sampled phase encoding points but is missing data for unsampled phase encoding points. The method further includes determining the missing data of at least one of the magnetic resonance data sets using a correlation between the sampled data for the respective magnetic resonance data set and sampled data from at least one other magnetic resonance data set within a spectral window encompassing at least the respective magnetic resonance data set and the at least one other magnetic resonance data set. | 10-18-2012 |
Xiao-Hua Chen, Palo Alto, CA US
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20090163594 | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors - The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a substrate specific manner. The invention provides an isolated cell wherein the cell stably expresses APP and at least one gamma secretase substrate other than APP. The invention provides assays and methods comprising contacting a cell with gamma secretase and detecting production of Abeta, detecting production of intracellular domain (ICD), and detecting a signal from a reporter gene under transcriptional control of the ICD. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds. | 06-25-2009 |
Xiaoqi Chen, Palo Alto, CA US
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20110034487 | CXCR3 ANTAGONISTS - Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, transplant rejection and type I diabetes. | 02-10-2011 |
20110319378 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 12-29-2011 |
20120244110 | FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3 - Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: | 09-27-2012 |
20140163052 | FUSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3 - Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: | 06-12-2014 |
20140235629 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, | 08-21-2014 |
20140315895 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 10-23-2014 |
Xingjie Chen, Palo Alto, CA US
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20100234578 | ANTI-CD40 MONOCLONAL ANTIBODY - An antibody or a functional fragment thereof, acting agonistically or antagonistically on CD40. | 09-16-2010 |
Xun Chen, Palo Alto, CA US
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20110083113 | System and Method for Lithography Simulation - There are many inventions described and illustrated herein. In one aspect, the present invention is directed to a technique of, and system for simulating, verifying, inspecting, characterizing, determining and/or evaluating the lithographic designs, techniques and/or systems, and/or individual functions performed thereby or components used therein. In one embodiment, the present invention is a system and method that accelerates lithography simulation, inspection, characterization and/or evaluation of the optical characteristics and/or properties, as well as the effects and/or interactions of lithographic systems and processing techniques. In this regard, in one embodiment, the present invention employs a lithography simulation system architecture, including application-specific hardware accelerators, and a processing technique to accelerate and facilitate verification, characterization and/or inspection of a mask design, for example, RET design, including detailed simulation and characterization of the entire lithography process to verify that the design achieves and/or provides the desired results on final wafer pattern. The system includes: (1) general purpose-type computing device(s) to perform the case-based logic having branches and inter-dependency in the data handling and (2) accelerator subsystems to perform a majority of the computation intensive tasks. | 04-07-2011 |
20120021343 | Process Window Signature Patterns for Lithography Process Control - A method for identifying process window signature patterns in a device area of a mask is disclosed. The signature patterns collectively provide a unique response to changes in a set of process condition parameters to the lithography process. The signature patterns enable monitoring of associated process condition parameters for signs of process drift, analyzing of the process condition parameters to determine which are limiting and affecting the chip yields, analyzing the changes in the process condition parameters to determine the corrections that should be fed back into the lithography process or forwarded to an etch process, identifying specific masks that do not transfer the intended pattern to wafers as intended, and identifying groups of masks that share common characteristics and behave in a similar manner with respect to changes in process condition parameters when transferring the pattern to the wafer. | 01-26-2012 |
20120269421 | System and Method for Lithography Simulation - In one aspect, the present invention is directed to a technique of, and system for simulating, verifying, inspecting, characterizing, determining and/or evaluating the lithographic designs, techniques and/or systems, and/or individual functions performed thereby or components used therein. In one embodiment, the present invention is a system and method that accelerates lithography simulation, inspection, characterization and/or evaluation of the optical characteristics and/or properties, as well as the effects and/or interactions of lithographic systems and processing techniques. | 10-25-2012 |
Yenyu Chen, Palo Alto, CA US
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20110251492 | ULTRASOUND ASSESSMENT OF LUMENS TO FACILITATE REPAIR OR REPLACEMENT - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. Located within the expandable member is an ultrasonic imaging probe and an acoustic reflective material. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining the orientation and shape of a lumen, particularly a cardiac valve. | 10-13-2011 |
20110276127 | MULTIPLE INFLATION OF AN EXPANDABLE MEMBER AS A PRECURSOR TO AN IMPLANT PROCEDURE - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. The devices and methods typically comprise deploying the expandable member percutaneously to a target location, expanding the expandable member, performing a valvuloplasty procedure to enlarge the diseased lumen and then performing an assessment of the diseased lumen with the expandable member to determine at least one property of the lumen. An implant device is inserted after assessment of the diseased lumen. | 11-10-2011 |
20120095334 | CONTROLLED INFLATION OF AN EXPANDABLE MEMBER DURING A MEDICAL PROCEDURE - Devices and methods for controlled inflation of a vessel lumen or a hollow portion of another organ located within a patient. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. The devices and methods typically comprise deploying the expandable member percutaneously to a target location, expanding the expandable member, and performing an expansion procedure. The expandable member expands at a controlled rate of inflation during a medical procedure. | 04-19-2012 |
20120116213 | ORIENTATION DETERMINATION OF A MEDICAL DEVICE WITHIN A PATIENT - Devices and methods for assessing the orientation and shape of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the orientation and shape of a lumen to, for example, perform a valvuloplasty or facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. Located within the expandable member are materials of different densities wherein the materials of different densities cooperate to indicate the orientation of the device within a lumen. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining the orientation and shape of a lumen. | 05-10-2012 |
20120172910 | SMART EXPANDABLE MEMBER FOR MEDICAL APPLICATIONS - Devices and methods for assessing the compliance of vessel lumens and hollow portions of organs are described. The devices and methods are particularly adapted for determining the compliance of the native heart valves to facilitate the later implantation of a prosthetic heart valve. The devices are typically catheter-based having an expandable member fixed to a distal end of the catheter. Located within the expandable member is an imaging member. The methods typically comprise deploying the balloon percutaneously to a target location, expanding the balloon, and determining the compliance of a lumen, particularly a cardiac valve. An optical coherence tomography apparatus is a preferred apparatus for determining compliance. | 07-05-2012 |
Yinming Chen, Palo Alto, CA US
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20120274233 | CONSTANT CURRENT LED DRIVER - A constant current LED driver comprising an LED driver to supply constant current to an LED circuit provided with a protection element, an open loop sensor to sense the open loop of the LED circuit and a clamping control to maintain the voltage in the LED circuit at a predetermined level. The open loop sensor may be a high voltage detector. The clamping control controls the power supplied to the LED circuit in response to the detection signals of the open loop sensor. In one embodiment, the clamping control controls the power supplied to the LED circuit according to the power of the detection signals. | 11-01-2012 |
Yixiang Chen, Palo Alto, CA US
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20110201351 | SYSTEM AND METHOD FOR PROVIDING MOBILE USER CLASSFICATION INFORMATION FOR A TARGET GEOGRAPHICAL AREA - A system and method for providing mobile user classification information for a target geographical area uses location information of mobile communication devices to detect the mobile communication devices within the target geographical area at a specified time and then further uses at least one of the location information of the detected mobile communication devices and Internet session information of the detected mobile communication devices to produce the mobile user classification information of the mobile communication devices within the target geographical area that are classified in one or more classifications. | 08-18-2011 |
20120207041 | SYSTEM AND METHOD FOR TAGGING CLIENT/NETWORK INFORMATION IN HEADERS OF DATA PACKETS - A system and method for tagging client/network information in mobile data packet traffic intercepts a data packet from a wireless mobile device, which includes client-related information embedded in a header of the data packet, at a mobile access network. The client-related information is then extracted from the data packet for processing. | 08-16-2012 |
20130102317 | ON-DEMAND DIRECTORY NUMBER CONTROL FUNCTION FOR A MOBILE DEVICE - The present invention a method for assigning a temporary dialable number to a device having a non-dialable number so that the device may have the capability to be connected with, such as in being called back. In addition to the numerous benefits provides by the present invention, mobile device user in particular, are provided benefits to enable the health, safety and security of individuals who utilize emergency-based systems that do not have a dialable mobile device number (MDN) by the present invention. | 04-25-2013 |
20130225201 | SYSTEM AND METHOD FOR LARGE-SCALE AND NEAR-REAL-TIME SEARCH OF MOBILE DEVICE LOCATIONS IN ARBITRARY GEOGRAPHICAL BOUNDARIES - A system and method for generating a one-dimensional spatial index and a temporal index in relation to one or more two-dimensional location points of one or more mobile devices to enable near-real-time searching of devices having fast-changing location information is provided for. The present invention may be used in a variety of implementations including being used in conjunction with searching for mobile devices within a geographical area for a time period; finding nearby devices within a time period; tracking device movement within a time period; determining clusters of devices for identification and location across different geographical regions at once. | 08-29-2013 |
20130282227 | METHOD AND APPARATUS FOR REMOTELY COMMUNICATING VEHICLE INFORMATION TO THE CLOUD - The present invention relates generally to the communication of vehicle data, diagnostics and related information with a network remote from the vehicle, and more particularly to communications and storage of vehicle data in the cloud. In one or more preferred embodiments, vehicle information is securely gathered from a vehicle, processed in accordance with instructions and a profile set remotely, and stored at a remote data store, where remote access to such information can be accommodated through applications, smartphones and other remote devices. | 10-24-2013 |
20140141767 | UTILIZING DEVICES NEARBY - The present invention relates generally to network communications, and more particularly to detecting devices having communications issues on a network. The present invention provides for determining a communications performance status in relation to a device on a communications network experiencing a communications issue by identifying the device, locating reference devices in relation to the identified device, and determining where a performance deficiency may exist in relation to the identified device and the communications network. | 05-22-2014 |
20140192660 | RADIO MODULE AS WEB-CONTROLLABLE REMOTE SENSOR - The present invention provides for network control of a radio module having a plurality of input/output (I/O) ports capable of communication with one or more sensing devices across a network, where the radio module may be controlled remotely to obtain information from one or more networked remote sensing devices. | 07-10-2014 |
20140279129 | REAL-TIME PRICED (RTP) CELLULAR SERVICE MARKETPLACE - A computer-implemented method and system for buying and selling cellular service in a market allowing real-time pricing is disclosed. The computer-implemented method and system comprise storing at least one offer to sell a specified quantity of cellular service (which may be voice minutes, messages, data or other available service parameters) initiated by a seller, and processing one or more requests to purchase cellular service initiated by one or more buyers. The processing of the requests to purchase cellular service further comprises implementing a method for matching one or more requests to purchase cellular service with any stored offers; wherein when a match occurs the buyer is able to purchase the desired quantity of cellular service. The computer-implemented method and system includes deducting the purchased quantity of cellular service from a service profile of the seller and adding the purchased quantity of cellular service to a service profile of the buyer. | 09-18-2014 |
20140280157 | MANAGEMENT OF DATA FEEDS FROM DEVICES AND PUBLISHING AND CONSUMPTION OF DATA - The present invention is directed towards a computer-implemented method and system for managing device data feeds. The computer-implemented method and system comprise using a data model to describe type of data received from the devices, grouping the received type of data based on a data description, and forwarding the device data to a receiver endpoint as directed by the subscription information comprising a receiver endpoint and a rule uniquely identified by the subscription identifier using application programming interface key to manage access to the device data. | 09-18-2014 |
20150215191 | UTILIZING DEVICES NEARBY - The present invention relates generally to network communications, and more particularly to detecting devices having communications issues on a network. The present invention provides for determining a communications performance status in relation to a device on a communications network experiencing a communications issue by identifying the device, locating reference devices in relation to the identified device, and determining where a performance deficiency may exist in relation to the identified device and the communications network. | 07-30-2015 |
Yizheng Chen, Palo Alto, CA US
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20140245298 | Adaptive Task Scheduling of Hadoop in a Virtualized Environment - A control module is introduced to communicate with an application workload scheduler of a distributed computing application, such as a Job Tracker node of a Hadoop cluster, and with the virtualized computing environment underlying the application. The control module periodically queries for resource consumption data, such as CPU utilization, and uses the data to calculate how MapReduce task slots should be allocated on each task node of the Hadoop cluster. The control module passes the task slot allocation to the application workload scheduler, which honors the allocation by adjusting task assignments to task nodes accordingly. The task nodes may also activate and deactivate task slots according to the changed slot allocation. As a result, the distributed computing application is able to scale up and down when other workloads sharing the virtualized computing environment change. | 08-28-2014 |
Yuan Chen, Palo Alto, CA US
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20120011517 | GENERATION OF OPERATIONAL POLICIES FOR MONITORING APPLICATIONS - Example embodiments relate to generation of operational policies for monitoring applications. In example embodiments, data generated based on decomposition of a Service Level Agreement (SLA) is received. Furthermore, in example embodiments, an operational policy is generated using the decomposition data. The operational policy may be used to control operation of a monitoring application. | 01-12-2012 |
20140278692 | MANAGING A FACILITY - In a method for managing a facility that is to receive resources from a first resource supply, a supply of resources available from the first resource supply is predicted for a predetermined period of time. In addition, a demand for resources in the facility during the predetermined period of time is predicted. A capacity schedule for the facility is planned to meet a predefined operational goal, in which the plan of the capacity schedule uses as inputs, the predicted supply of resources available from the first resource supply and the predicted demand for resources in the facility during the predetermined period of time. Moreover, a determination as to whether the planned capacity schedule meets the predefined operational goal is made. | 09-18-2014 |
20140324407 | QUANTIFYING POWER USAGE FOR A SERVICE - Quantifying power usage for a service. An example method may include identifying a dependency model for the service, the dependency model based in part on infrastructure providing the service. The method may also include determining power usage for the service using the dependency model. | 10-30-2014 |