Patent application number | Description | Published |
20080207683 | BIARYL-SUBSTITUTED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Biaryl-substituted tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 08-28-2008 |
20080269241 | BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 10-30-2008 |
20090118274 | MONOCYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S - Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. | 05-07-2009 |
20120232062 | AZAINDAZOLES TO TREAT FLAVIVIRIDAE VIRUS INFECTION - Azaindazole compounds are useful for treating Flaviviridae virus infection, including HCV infection. | 09-13-2012 |
20150051193 | PI-kinase Inhibitors with Broad Spectrum Anti-Infective Activity - Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like. | 02-19-2015 |
Patent application number | Description | Published |
20100015093 | Methods and compositions of treating a flaviviridae family viral infection - Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like. | 01-21-2010 |
20100028299 | Methods and compositions of treating a flaviviridae family viral infection - Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like. | 02-04-2010 |
Patent application number | Description | Published |
20100034386 | DEVICE MANAGER REPOSITORY - Apparatus, systems and methods for managing wireless devices. A wireless device identifier from an access device is received. An encryption key associated with the wireless device identifier that matches an encryption key stored in the wireless device is identified. The identified encryption key is transmitted to the access device so that the access device can communicate with the wireless device over an encrypted communication channel that is established by use of the identified encryption key and the encryption key stored in the wireless device. | 02-11-2010 |
20100135186 | Network Analysis System and Method - A system for analyzing a packet-based network includes a wireless network analysis processing device that is configured to receive correlated packet records representative of the order in which corresponding packets are transmitted in a wireless network. The correlated packet records include media access control (MAC) layer data and network layer data for each corresponding packet. The MAC layer data and network layer data are processed to generate network topology data representative of the network topology, generate packet flow data representative of the flow of packets between devices at the MAC layer and across the network at the network layer, and measurement data relating to the packet flow data. | 06-03-2010 |
20110172844 | Wireless System Commissioning - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for commissioning a wireless network. In one aspect, a method includes instructing the switch devices of the controlled circuits to provide power to the controlled circuit wiring of the controlled circuits to enable joining of wireless adapters to the wireless network; monitoring the joining of wireless adapters to the wireless network; monitoring for the occurrence of a joining expiration event; and in response to the occurrence of the joining expiration event, determining whether each wireless adapter that joined the wireless network during a joining time period ending at the occurrence of the joining expiration event belongs to the controlled circuits. | 07-14-2011 |
20120007511 | AMBIENT AND TASK LEVEL LOAD CONTROL - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task level lighting for task areas in the controlled area, wherein each task area is a separate sub-area of the controlled area. | 01-12-2012 |
20120112654 | Wireless Adaptation of Lighting Power Supply - Methods, systems, and apparatus, for wirelessly controlling a power supply device that controls a load. A wireless adapter includes a wireless communication device that receives transmissions from a wireless controller, a serial interface for a serial data connection to a power supply processing device integrated in the power supply device, an adapter processing device that receives the control signals the wireless communication device outputs, generates the control commands from the control signals, and outputs the control commands to the serial interface to cause the power supply processing device to control power provided to the load in a manner specified by the control commands, and an adapter power circuit that receives regulated direct current (DC) power from the power supply device and is powered from the regulated DC power received, and provides power to the wireless communication device and the adapter processing device. | 05-10-2012 |
20130200809 | Integrated Ambient and Task Lighting Control - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for cooperatively controlling ambient level lighting in a controlled area, and task-level lighting for task areas in the controlled area, where each task area is a separate sub-area of the controlled area. | 08-08-2013 |
Patent application number | Description | Published |
20080245788 | ELECTRIC APPLIANCE WITH INTERIOR LIGHTING - An electric appliance comprises in particular an interior space which is separable from an outside environment and at least one radiation-emitting device arranged in the interior space for emitting electromagnetic radiation into the interior space. | 10-09-2008 |
20100035268 | MATERIALS AND METHODS FOR SINGLE MOLECULE NUCLEIC ACID SEQUENCING - Provided herein are methods and compositions for real time single molecule sequencing of short nucleotide sequences using nucleotide fluorescent semiconductor nanocrystals-conjugated nucleotide primers. | 02-11-2010 |
20100255487 | METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING USING ENERGY TRANSFER DETECTION - Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule. | 10-07-2010 |
20110281740 | Methods for Real Time Single Molecule Sequencing - Provided herein are methods and compositions for real time single molecule sequencing of a polymeric molecule, such as a polynucleotide, by isolating the polymeric molecule in a nanofluidic device, subjecting it in situ to a polymerase reaction wherein various components of the polymerase reaction mixture are labeled, and determining the time-sequence of incorporation of monomeric subunits during the polymerization process. | 11-17-2011 |
20120153305 | Radiation Emitting Device - A radiation emitting device comprising a first electrode, which emits first charge carriers having a first charge during operation, a first charge carrier transporting layer, which comprises a fluorescent substance, a second charge carrier transporting layer, which contains a phosphorescent substance, and a second electrode, which emits second charge carriers having a second charge during operation, wherein during operation the second charge carrier transporting layer is largely free of first charge carriers. | 06-21-2012 |
20120329042 | METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING USING ENERGY TRANSFER DETECTION - Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule. | 12-27-2012 |