Patent application number | Description | Published |
20110251568 | PUNCTAL PLUGS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled release into the eye by means of an osmotic engine. | 10-13-2011 |
20110301555 | POROUS MATRIX DRUG CORE FOR LACRIMAL INSERT DEVICE - Disclosed are novel structures and methods for drug cores containing therapeutic agents. Such cores may be inserted or manufactured in lacrimal insert devices for treating a variety of ocular conditions by eluding therapeutic agents according to a release profile determined by the structure and composition of the drug core. | 12-08-2011 |
20110311606 | PUNCTAL PLUGS WITH CONTINUOUS OR PULSATILE DRUG RELEASE MECHANISM - Disclosed are lacrimal inserts and their method of use for delivery of of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye. | 12-22-2011 |
20110311607 | PUNCTAL PLUGS WITH CONTINUOUS OR PULSATILE DRUG RELEASE MECHANISM - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye. | 12-22-2011 |
20120059338 | PUNCTAL PLUG CONTAINING DRUG FORMULATION - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye and is configured for release medication via a designated port, valve, or orifice in the insert housing and inhibits diffusion of medication via the housing itself. | 03-08-2012 |
20120197217 | PUNCTAL PLUGS WITH DIRECTIONAL RELEASE - Disclosed are lacrimal inserts and their method of use for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid and includes means for directional release of medication into the lacrimal fluid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye. | 08-02-2012 |
20120283669 | PUNCTAL PLUGS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS - Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye. | 11-08-2012 |
20130018360 | METHOD FOR DELIVERING OPHTHALMIC DRUGS - This invention relates to a method of delivering ophthalmic drugs, specifically prostaglandins and prostamides. This method may also be applied to other types of intraocular pressure (IOP)-lowering drugs (e.g. carbonic anhydrase inhibitors, beta blockers, alpha-adrenergic agonists, and parasympathomimetics) as well as other types of ophthalmic drugs for other indications (e.g. dry eye, inflammation, and infection). | 01-17-2013 |
20130184661 | EYE DRUG DELIVERY SYSTEM - A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug. | 07-18-2013 |
Patent application number | Description | Published |
20100196366 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 08-05-2010 |
20120177641 | Gefitnib Sensitivity-Related Gene Expression and Products and Methods Related Thereto - Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to EGFR inhibitors, and products and processes related thereto. In one embodiment, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described. | 07-12-2012 |
Patent application number | Description | Published |
20080315008 | Four wire elastomeric seal and fuel injector using same - A fuel injector includes first and second electrical actuators positioned within an injector body. First and second pairs of electrical conductors extend from a socket connector outside of the injector body to the first and second electrical actuators, respectively. The electrical conductors extend through an elastomeric sealing member that seals against fuel leakage from the fuel injector. The elastomeric sealing member provides annular sealing ridges in sealing contact with an access passage of the injector body and includes individual conductor seal passages that form seals around the outer surface of the individual electrical conductors. The elastomeric sealing member includes features that facilitate assembly of the fuel injector in a manner that reduces risk of damage to the sealing strategy. | 12-25-2008 |
20100029115 | FOUR WIRE ELASTOMERIC SEAL AND FUEL INJECTOR USING SAME - A fuel injector includes first and second electrical actuators positioned within an injector body. First and second pairs of electrical conductors extend from a socket connector outside of the injector body to the first and second electrical actuators, respectively. The electrical conductors extend through an elastomeric sealing member that seals against fuel leakage from the fuel injector. The elastomeric sealing member provides annular sealing ridges in sealing contact with an access passage of the injector body and includes individual conductor seal passages that form seals around the outer surface of the individual electrical conductors. The elastomeric sealing member includes features that facilitate assembly of the fuel injector in a manner that reduces risk of damage to the sealing strategy. | 02-04-2010 |
20110290211 | Low Leakage Cam Assisted Common Rail Fuel System, Fuel Injector, And Operating Method Therefor - A fuel system includes a plurality of fuel injectors each defining a nozzle supply passage, a nozzle outlet and a low pressure space. The fuel system includes a plurality of mechanically actuated pressure intensifiers each including a tappet and being positioned partially within one of the fuel injectors, and a common rail fluidly connecting with each of the fuel injectors. Each of the fuel injectors further includes an injection pressure control mechanism having an injection pressure control valve. Each injection pressure control valve blocks the corresponding pressure intensifier from the common rail and fluidly connects the pressure intensifier with the low pressure space at a first position, and fluidly connects the pressure intensifier with the common rail and blocks the pressure intensifier from the low pressure space at a second position. Injecting fuel via operating the fuel system may include operating the fuel system in a low leakage mode where the pressure intensifier displaces fuel at a low pressure, between high pressure injections. | 12-01-2011 |
20130118448 | Dual Fuel Common Rail System And Fuel Injector - A dual fuel system includes a plurality of fuel injectors that each have a non-injection configuration, a liquid fuel injection configuration, a gaseous fuel injection configuration and a combined fuel injection configuration. Each of the fuel injectors includes a liquid control valve member with a guide segment that defines a portion of a leak path from the a liquid fuel inlet to a drain outlet, and a gas control valve member with a guide segment that defines a second leak path from the liquid fuel inlet to the drain outlet. Each injector body includes a tip component that defines both a liquid nozzle outlet set and a gas nozzle outlet set. A dual solenoid actuator has a first armature coupled to the liquid control valve member, a second armature coupled to the gas control valve member, and a shared stator. | 05-16-2013 |
Patent application number | Description | Published |
20130000602 | METHODS AND SYSTEMS FOR CONTROLLING FUEL SYSTEMS OF INTERNAL COMBUSTION ENGINES - A method of operating a power system is disclosed. The power system may include an engine. The engine may include a combustion chamber, a drive member, and a fuel system with a fuel injector. The method may include selectively operating the fuel system to supply fuel from the fuel injector to the combustion chamber and combusting the fuel in the combustion chamber to drive the drive member. The method may also include selectively operating the fuel system to generate parasitic losses without supplying fuel to the combustion chamber to drive the drive member. Operating the fuel system to generate parasitic losses may include generating pressure in a component of the fuel system with power derived from the engine and dissipating at least a portion of the generated pressure without delivering fuel from the fuel injector to the combustion chamber. | 01-03-2013 |
20130327296 | Dual Fuel Common Rail Engine With Co-Axial Quill Assembly - A dual fuel common rail engine supplies pressurized natural gas and liquid diesel fuel at different pressures through a co-axial quill assembly for direct injection from a single fuel injector into an engine cylinder. Pressure waves in the gaseous fuel common rail are damped in a pressure damping chamber of the co-axial quill assembly before the pressure wave can undermine consistent gaseous fuel injection rates and quantities from the fuel injector. | 12-12-2013 |
20140033945 | CONSIST POWER SYSTEM HAVING AUXILIARY LOAD MANAGEMENT - The disclosure is directed to a power system for a consist. The power system may have a main engine located onboard a locomotive of the consist, a main generator driven by the main engine to generate a main supply of electric power, and a traction motor configured to receive the main supply of electric power and propel the locomotive. The power system may also have an auxiliary engine located on a tender car towed by the locomotive, and an auxiliary generator driven by the auxiliary engine to generate an auxiliary supply of power directed to the locomotive. | 02-06-2014 |
20140174404 | FUEL SYSTEM - A fuel system for a dual fuel power source includes a first fuel circuit fluidly connected to the power source, a second fuel circuit separate from the first fuel circuit and fluidly connected to the power source, and a pressure regulator fluidly connected to the first fuel circuit. The pressure regulator is configured to vent a first fuel from the first fuel circuit to an aftertreatment system fluidly connected to the power source in response to a pressure difference between the first and second fuel circuits being less than or equal to a pressure difference threshold. | 06-26-2014 |
20150369177 | ENGINE SYSTEM HAVING PIEZO ACTUATED GAS INJECTOR - A fuel injector is disclosed for use in an engine system. The fuel injector may have a body, a first piston slidingly disposed in the body and having a first pressure area, and a second piston slidingly disposed in the body and having a second pressure area. The fuel injector may also have a hydraulic coupling connecting the first and second pressure areas, and a piezo stack connected to move the first piston. The fuel injector may additionally have a valve needle configured to engage and be moved by the second piston. The first pressure area may be larger than the second pressure area. | 12-24-2015 |
Patent application number | Description | Published |
20080285603 | TUNABLE LASER SOURCE WITH INTEGRATED OPTICAL MODULATOR - A tunable laser source with integrated optical modulator. The tunable laser source is a widely tunable semiconductor laser that is comprised of an active region on top of a thick, low bandgap, waveguide layer, wherein both the waveguide layer and the active region are fabricated between a p-doped region and an n-doped region. An electro-absorption modulator is integrated into the semiconductor laser, wherein the electro-absorption modulator shares the waveguide layer with the semiconductor laser. | 11-20-2008 |
20090262765 | SMALL DIMENSION HIGH-EFFICIENCY HIGH-SPEED VERTICAL-CAVITY SURFACE-EMITTING LASERS - A Vertical-Cavity Surface-Emitting Laser (VCSEL) is disclosed, comprising an optical cavity bounded by a top mirror and a bottom mirror, wherein the top mirror has multiple layers of alternating refractive index, of which the bottom three or more layers of the top mirror are deep oxidation layers having an increased oxidation length, a light emitting active region between the top mirror and the bottom mirror, and an aperture with tapered edges between the active region and the top mirror, wherein the aperture has a thickness, a taper length, an oxide aperture length, a taper angle, and an aperture opening diameter designed to reduce an optical mode's diameter without significantly increasing the optical mode's round trip scattering loss. | 10-22-2009 |