Cutcliffe
Colleen Cutcliffe, Menlo Park, CA US
Patent application number | Description | Published |
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20120034602 | Recombinant Polymerases For Improved Single Molecule Sequencing - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 02-09-2012 |
20130217007 | Recombinant Polymerases With Increased Phototolerance - Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template. | 08-22-2013 |
Colleen Tsui Cutcliffe, San Francisco, CA US
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20090023178 | Parkin Substrate and Assay - The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity. | 01-22-2009 |
Colleen Tsui Cutcliffe, Menlo Park, CA US
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20120083003 | PARKIN SUBSTRATE AND ASSAY - The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity. | 04-05-2012 |
Graham Stephen Cutcliffe, Caringbah AU
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20110174308 | PRESSURE CONTROL IN RESPIRATORY TREATMENT APPARATUS - An over-pressure control device prevents over-pressure conditions during the delivery of pressure treatment therapy to a patient with a respiratory treatment apparatus. The device may prevent delivered pressure from exceeding a first maximum pressure threshold. The device may also prevent the delivered pressure from exceeding a second maximum pressure threshold when the delivered pressure exceeds another pressure threshold for a period of time. In some embodiments, the second maximum pressure threshold may be lower than the first maximum pressure threshold. In an example embodiment, a set of comparators are configured to compare pressure with a maximum pressure threshold and to control a reduction in the pressure if the pressure exceeds the maximum pressure threshold. The set may also be configured to compare the pressure with a pressure threshold and to control reduction in the maximum pressure threshold if the pressure exceeds the pressure threshold for a period of time. | 07-21-2011 |
20120227738 | CPAP SYSTEMS - A CPAP system includes a flow generator ( | 09-13-2012 |
20130239960 | MODULARIZED RESPIRATORY TREATMENT APPARATUS - A modularized respiratory treatment apparatus provides various respiratory pressure treatments. The apparatus may be formed by discrete connectable modules such as a flow generator module, alarm module and/or humidifier module. Each module may include its own external casing or housing to independently retain or enclose the respective components that serve the function of the module. Different modules may be adapted with different components and functionalities and may be readily coupled using standardized gas and electrical connection configurations that have flow and communication paths that extend through the modules. When coupled, operation of the respiratory treatment apparatus may be controlled by detection of different modules, such as the alarm module that generates visual and/or audible alarms based on detected conditions, so as to selectively enable or disable different respiratory treatments. The discrete modules of the medical treatment apparatus may include tamper resistant locking mechanisms to impede unauthorized separation of some modules. | 09-19-2013 |