Darja
Darja Lavõgina, Tartu EE
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20100233743 | BISUBSTRATE FLUORESCENT PROBE BINDING TO PROTEIN KINASES - This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to both ATP binding site and/or substrate protein/peptide binding domain of the kinase. High affinity of the probe (K | 09-16-2010 |
Darja Lavõgina, Tartu EE
Patent application number | Description | Published |
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20100233743 | BISUBSTRATE FLUORESCENT PROBE BINDING TO PROTEIN KINASES - This invention relates to fluorescent probes for identification of compounds binding to protein kinases, for measurement of the affinity of inhibitors of protein kinases, and determination of the active concentration of protein kinases binding to the probe. Bisubstrate-analog character of the probe enables the simultaneous evaluation of inhibitors targeted to both ATP binding site and/or substrate protein/peptide binding domain of the kinase. High affinity of the probe (K | 09-16-2010 |
Darja Marolt, Ljublijana SI
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20140147419 | COMPOSITIONS AND METHODS FOR FORMATION OF BONE TISSUE - Provided is a step-wise method of forming an engineered construct. Various embodiments include inducing differentiation of progenitor cells, such as embryonic stem cells; expanding the differentiated progenitor cells; combining the expanded progenitor cells and a biocompatible scaffold comprising a matrix material; and incubating the progenitor cells and the biocompatible scaffold so as to form a bone tissue module. | 05-29-2014 |
Darja Obrstar, Menges SI
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20130302816 | NUCLEAR DNA CONTENT OF CHO CELL LINES AS A SELECTION CRITERION IN SCREENING OF THE BEST RECOMBINANT PROTEIN PRODUCERS - The present invention relates to a method for selecting for cells or cell lines that produce a recombinant protein/polypeptide in high yields, the method allowing for the selection of high producer cells or cell lines in an early phase of cell line development, the method comprising the step of determining the nuclear DNA content of the cells or cell lines, wherein the level of the nuclear DNA content of the cells or cell lines positively correlates with the capacity of the cells or cell lines to produce the recombinant protein/polypeptide. | 11-14-2013 |
Darja Pavlin, Straza SI
Patent application number | Description | Published |
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20100105908 | Process For The Preparation Of Levocetirizine And Intermediates Thereof - The present invention describes a novel process for the preparation of levocetirizine and pharmaceutically acceptable acid addition salts thereof using diglycolic acid or derivatives thereof and new intermediates used in that process. | 04-29-2010 |