Patent application number | Description | Published |
20090324605 | INTERFERON ALPHA ANTIBODIES AND THEIR USES - The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention. | 12-31-2009 |
20100104569 | HUMANIZED ANTIBODIES TO INTERFERON ALPHA RECEPTOR-1 (IFNAR-1) - Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies. | 04-29-2010 |
20100303817 | ANTIBODIES TO TREAT CANCER - Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell. | 12-02-2010 |
20110086422 | HUMANIZED ANTIBODIES TO INTERFERON ALPHA RECEPTOR-1 (IFNAR-1) - Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies. | 04-14-2011 |
20110165158 | METHODS FOR THE THERAPY OF INFLAMMATORY BOWEL DISEASE USING A TYPE-1 INTERFERON ANTAGONIST - Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn's Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR). | 07-07-2011 |
20110300145 | Interferon Alpha Antibodies And Their Uses - The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention. | 12-08-2011 |
20130254912 | INTERFERON ALPHA ANTIBODIES AND THEIR USES - The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention. | 09-26-2013 |
20140199328 | Interferon Alpha Antibodies And Their Uses - The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention. | 07-17-2014 |
Patent application number | Description | Published |
20080281079 | Bioactivation Of Particles - Particles are bioactivated by attaching bioactivation peptides to the particle surface. The bioactivation peptides are peptide-based compounds that impart one or more biologically important functions to the particles. Each bioactivation peptide includes a molecular or surface recognition part that binds with the surface of the particle and one or more functional parts. The surface recognition part includes an amino-end and a carboxy-end and is composed of one or more hydrophobic spacers and one or more binding clusters. The functional part(s) is attached to the surface recognition part at the amino-end and/or said carboxy-end. | 11-13-2008 |
20100262488 | POLICY-BASED MEDIA SYNDICATION AND MONETIZATION - Hosted content received from media hosts is used to generate a set of fingerprints representing the hosted content. The fingerprints representing the hosted content are compared to a set of fingerprints representing reference content submitted by content owners to generate one or more match metrics. Based on the match metrics, the media host may provide indication that they accept policy terms specified by the content owners, including revenue sharing terms. If the media host accepts the revenue sharing terms, the media host may provide advertising content to viewers in association with the hosted content matching the reference content. Funds received from providing advertising content are distributed to the media host and the content owner according to the revenue sharing terms. | 10-14-2010 |
20100263020 | POLICY-BASED VIDEO CONTENT SYNDICATION - An item of hosted content is received from a media host. A match metric representing an aspect of a match between the item of hosted content and an item of reference content, the item of reference content provided by a content owner having rights to the item of reference content. A policy associated with the item of reference content is identified responsive to the value to that represents the correspondence, the policy including terms of use for the hosted content. The policy is provided to the media host. | 10-14-2010 |
20120016724 | POLICY-BASED MEDIA SYNDICATION AND MONETIZATION - Hosted content received from media hosts is used to generate a set of fingerprints representing the hosted content. The fingerprints representing the hosted content are compared to a set of fingerprints representing reference content submitted by content owners to generate one or more match metrics. Based on the match metrics, the media host may provide indication that they accept policy terms specified by the content owners, including revenue sharing terms. If the media host accepts the revenue sharing terms, the media host may provide advertising content to viewers in association with the hosted content matching the reference content. Funds received from providing advertising content are distributed to the media host and the content owner according to the revenue sharing terms. | 01-19-2012 |
20130014209 | Content Management System - Content rights holders provide digital content to a hosting site to be used as reference content. The content owner specifies a policy for each digital content item, indicating how that content may be used on the site when uploaded by someone other than the content owner. An identification module compares the uploaded content against reference content. If the content matches reference content, the specified policy for that reference content is applied to the uploaded content. Policy options provided by the content owner include tracking the content to see how it is viewed, preventing the content from being distributed on the site, and allowing the content to be displayed in a revenue-sharing environment. In one embodiment, if the identification module matches the uploaded content to a reference item but the match does not have a sufficiently high level of confidence, the suggested match is queued for review by the content owner. | 01-10-2013 |
Patent application number | Description | Published |
20090239078 | Process and apparatus for diamond synthesis - The present invention relates to a microwave plasma deposition process and apparatus for producing diamond, preferably as single crystal diamond (SCD). The process and apparatus enables the production of multiple layers of the diamond by the use of an extending device to increase the length and the volume of a recess in a holder containing a SCD substrate as layers of diamond are deposited. The diamond is used for abrasives, cutting tools, gems, electronic substrates, heat sinks, electrochemical electrodes, windows for high power radiation and electron beams, and detectors. | 09-24-2009 |
20100034984 | Microwave plasma reactors - New and improved microwave plasma assisted reactors, for example chemical vapor deposition (MPCVD) reactors, are disclosed. The disclosed microwave plasma assisted reactors operate at pressures ranging from about 10 Torr to about 760 Torr. The disclosed microwave plasma assisted reactors include a movable lower sliding short and/or a reduced diameter conductive stage in a coaxial cavity of a plasma chamber. For a particular application, the lower sliding short position and/or the conductive stage diameter can be variably selected such that, relative to conventional reactors, the reactors can be tuned to operate over larger substrate areas, operate at higher pressures, and discharge absorbed power densities with increased diamond synthesis rates (carats per hour) and increased deposition uniformity. | 02-11-2010 |
20130069531 | MICROWAVE PLASMA REACTORS - New and improved microwave plasma assisted reactors, for example chemical vapor deposition (MPCVD) reactors, are disclosed. The disclosed microwave plasma assisted reactors operate at pressures ranging from about 10 Torr to about 760 Torr. The disclosed microwave plasma assisted reactors include a movable lower sliding short and/or a reduced diameter conductive stage in a coaxial cavity of a plasma chamber. For a particular application, the lower sliding short position and/or the conductive stage diameter can be variably selected such that, relative to conventional reactors, the reactors can be tuned to operate over larger substrate areas, operate at higher pressures, and discharge absorbed power densities with increased diamond synthesis rates (carats per hour) and increased deposition uniformity. | 03-21-2013 |
20130101730 | MICROWAVE PLASMA REACTORS - New and improved microwave plasma assisted reactors, for example chemical vapor deposition (MPCVD) reactors, are disclosed. The disclosed microwave plasma assisted reactors operate at pressures ranging from about 10 Torr to about 760 Torr. The disclosed microwave plasma assisted reactors include a movable lower sliding short and/or a reduced diameter conductive stage in a coaxial cavity of a plasma chamber. For a particular application, the lower sliding short position and/or the conductive stage diameter can be variably selected such that, relative to conventional reactors, the reactors can be tuned to operate over larger substrate areas, operate at higher pressures, and discharge absorbed power densities with increased diamond synthesis rates (carats per hour) and increased deposition uniformity. | 04-25-2013 |
Patent application number | Description | Published |
20090211845 | Lockable folding stairs - A two-piece locking folding stair is provided with a spring-like locking mechanism. The spring-like device, deployed one on of the two members, includes a protruding member which engages a notch on the other member when the stairs are in the full open, or locked position. When the stairs are opened, the device moves into a position which prevents the stairs from folding unintentionally. To unlock the assembly, the spring-like device is depressed thus releasing the protruding member from a corresponding notch, allowing the stairs to be folded to the closed position for stowing or transport. | 08-27-2009 |
20130213319 | PET HARNESS FOR ASSISTING PET MOBILITY - The invention presents a harness assembly for lifting and supporting an animal in mobility. The assembly comprises a front and rear harness sections releasably attached by a lifting leash. Both the front and rear harness sections can be used independently. Both the front and rear harness sections are comprised of upper and lower sections releasably attached to one another. The rear harness section lifts the animal from both the hips and waist resulting in less stress than other devices. | 08-22-2013 |
20140033987 | MODULAR ANIMAL EXERCISE STRUCTURE - A modular play structure for animals has base and platform pieces with connector mechanisms, such countersunk bores, spaced apart by a standard distance. Thus platforms and bases can be oriented in multiple directions and are interchangeable. Columns space the bases and platforms vertically. Columns may be of varying height, preferably with different heights described by a common factor. Stacked columns are connected end-to-end with a spacer of the same thickness as a platform interposed therebetween. Columns are oriented in the same direction with female and male ends connecting with platform, base, and adjacent columns. | 02-06-2014 |
Patent application number | Description | Published |
20140209041 | Companion Water Heater - A hot water heater appliance includes a boiler, a companion water heater and a controller. The controller is configured to control the water heater appliance in response to a scheduled plurality of performance modes based on a preset schedule. A first performance mode is scheduled to be performed at an expected low usage time and a second performance mode is scheduled to be performed at an expected high usage time relative to the expected low usage time. | 07-31-2014 |
20140209042 | Dual Sensor Companion Water Heater - A hot water heater appliance includes a boiler, companion water heater, and a controller. The companion water heater has a hot water storage tank. The controller is configured to control the water heater appliance in response to a sensed temperature at an upper portion of the hot water storage tank and a sensed temperature at a lower portion of the hot water storage tank. The controller is configured to control the boiler to quickly heat water in the hot water storage tank in response to both upper and lower temperatures of the hot water storage tank being below a predetermined temperature and the controller is configured to more slowly heat water in the hot water storage tank in response to the upper temperature of the hot water storage tank being above the predetermined temperature and the lower temperature of the hot water storage tank being below the predetermined temperature. | 07-31-2014 |
20140209043 | Companion Water Heater Jacket - A jacket for a hot water heater appliance includes a top, bottom, front, back, and a fastener. The top is configured to insulate an upper portion of a hot water tank. The bottom is configured to insulate a lower portion of the hot water tank. The front is configured to insulate a front portion of the hot water tank. The back is configured to insulate a back portion of the hot water tank. The fastener is configured to releaseably fasten the front to the back. The top, bottom, front and back include expanded polypropylene (EPP) configured to provide insulation to the hot water tank. | 07-31-2014 |