De Haard
Johannes De Haard, Na Oudelande NL
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20150218239 | FCRN Antagonists and Methods of Use - Provided are novel FcRn antagonist compositions comprising a variant Fc region that binds specifically to FcRn with increased affinity and reduced pH dependence relative to the native Fc region. Also provided are FcRn antagonists with enhanced CD16 binding affinity. Also provided are methods of treating antibody-mediated disorders (e.g. autoimmune diseases) using the these FcRn antagonist compositions, nucleic acids encoding the FcRn antagonist compositions, recombinant expression vectors and host cells for making the FcRn antagonist compositions, and pharmaceutical compositions comprising the FcRn antagonist compositions. | 08-06-2015 |
Johannes Joseph De Haard, Naarden NL
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20140256579 | Protein Arrays - Protein arrays are provided comprising single domain antibodies obtainable from | 09-11-2014 |
Johannes Joseph Wilhelmus De Haard, Na Oudelande NL
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20140147450 | ANTIBODIES TO CD70 - The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth. | 05-29-2014 |
20140235843 | ANTIBODIES TO CD70 - The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth. | 08-21-2014 |
Johannes Joseph Wilhelmus De Haard, Breda NL
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20140286976 | CHIMERIC HUMAN-LLAMA ANTIGENS AND METHODS OF USE - Provided are chimeric, camelid-human (e.g., llama-human) polypeptides comprising a first antigenic polypeptide portion and a second antigenic polypeptide portion wherein the first antigenic portion is a derived from a first portion of a camelid (e.g., llama) and the second antigenic portion is a human polypeptide homolog of a second portion of the camedid antigen. The chimeric polypeptides are useful inter alia for epitope mapping and generation of antibodies that bind to a desired region of human antigen. | 09-25-2014 |
Johannes Joseph Wilhelmus De Haard, Ah Breda NL
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20150191548 | ANTIBODIES COMPRISING SEQUENCES FROM CAMELIDAE TO HIGHLY CONSERVED TARGETS - The present invention is concerned with antigen binding polypeptides, and in particular conventional antibodies derived from camelid species, that specifically bind to target antigens that are either self-antigens or highly conserved antigens. The present invention also relates to anti-idiotype antigen binding peptides which bind to a target antigen comprising the variable region of an antibody obtained from a species within the family Camelidae. | 07-09-2015 |
Johannes Joseph Wilhelmus De Haard, Willemstraat NL
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20150203840 | METHOD FOR PRODUCING ANTIBODY MOLECULES HAVING INTER-SPECIES, INTRA-TARGET CROSS-REACTIVITY - A method is disclosed for producing an antibody molecule having inter-species, intra-target cross-reactivity. The method comprises the steps of creating a first immune library for a target antigen from a first species, for example man; combining variable regions from the first immune library in a chain shuffling protocol, to produce a second immune library; and screening the second immune library for affinity to both the target antigen and a corresponding antigen from a second species. The second species is different from the first species. By using a suitable test animal as the second species, the method paves the way to convenient testing of the antibody molecule. | 07-23-2015 |